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ALOX12P2 Gene

pseudogene   GIFtS: 25
GCID: GC17P006759

Arachidonate 12-Lipoxygenase Pseudogene 2

  Search for ALOX12P2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Arachidonate 12-Lipoxygenase Pseudogene 21 2
ALOX12E2

External Ids:    HGNC: 4321   Entrez Gene: 2452   Ensembl: ENSG000002629437   

Export aliases for ALOX12P2 gene to outside databases

Previous GC identifers: GC17P007185 GC17P007528 GC17P006701 GC17U900075 GC17P006997 GC17P006737


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ALOX12P2 Gene:
ALOX12P2 (arachidonate 12-lipoxygenase pseudogene 2) is a pseudogene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NC_018928.2  NT_010718.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the ALOX12P2 gene promoter:
         p53   Lmo2   Olf-1   XBP-1   LCR-F1   C/EBPalpha   E2F-1   E2F   ZID   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ALOX12P2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p13.1

ALOX12P2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ALOX12P2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P006759:  view genomic region     (about GC identifiers)

Start:
6,757,180 bp from pter      End:
6,857,426 bp from pter
Size:
100,247 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB: --


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:
     Genatlas biochemistry entry for ALOX12P2:
arachidonate-12-lipoxygenase,epidermal type,expressed pseudogene

Phenotypes:
     1 MGI phenotypic allele for Alox12e (no phenotypes)

ALOX12P2 for phenotypes           About GeneDecksing

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ALOX12P2
Interactions:

    Search GeneGlobe Interaction Network for ALOX12P2

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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Unigene Cluster for ALOX12P2:

Arachidonate 12-lipoxygenase pseudogene 2
Hs.378695  [show with all ESTs]
Unigene Representative Sequence: AL832768
12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000574727(uc002gdu.1 uc002gdv.3) ENST00000573104 ENST00000576636
ENST00000574271 ENST00000570835 ENST00000571201 ENST00000570921 ENST00000570890(uc002gdw.3)
ENST00000572215 ENST00000572357 ENST00000575787 ENST00000574183
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Additional mRNA sequence: 

AF020774.1 AL832768.1 BC041851.1 NR_002710.2 

5 DOTS entries:

DT.110671  DT.100745274  DT.95261219  DT.101977689  DT.40118014 

Selected AceView cDNA sequences (see all 38):

BM973554 AW044581 BU689660 AA419264 BF589297 AI123817 AI142268 BX462645 
AL832768 BV175513 BE080128 AF020774 BF435282 AA411550 BC041851 BX456074 
AA411551 AA281429 BF510845 AA411432 BX110191 AA411441 AW044543 AI452641 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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ALOX12P2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GTAGAGAACA
ALOX12P2 Expression
About this image


ALOX12P2 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 3) fully expand
 
 Thymus (Hematopoietic System)
         Thymus
 
 Gut Tube (Gastrointestinal Tract)
         Foregut
 
 Ovary (Reproductive System)
ALOX12P2 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

SOURCE GeneReport for Unigene cluster: Hs.378695
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of human and mouse.

Orthologs for ALOX12P2 gene from 1 species (see representative species )    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Alox12e5 arachidonate lipoxygenase, epidermal   --   11 (42.99 cM) 70315610 


ENSEMBL Gene Tree for ALOX12P2 (if available)
TreeFam Gene Tree for ALOX12P2 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for ALOX12P2 (see all 962)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 17 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs733435131,2
C,F--6754904(+) GTGAGT/CGGGAA 1 -- us2k12Minor allele frequency- C:0.07WA 120
rs1869224391,2
--6754920(+) AGGAAA/GAGACA 1 -- us2k10--------
rs1902688211,2
--6754946(+) ATAAAC/TGCTGA 1 -- us2k10--------
rs1390679281,2
C--6755101(+) TGAGGA/GGTCAG 1 -- us2k10--------
rs116583361,2
C,F,A,H--6755104(+) GGGGTC/TAGAGG 1 -- us2k117Minor allele frequency- T:0.45NS EA NA WA CSA 1201
rs350470801,2
C--6755125(+) ACTAA-/TTTTTT 1 -- us2k10--------
rs2000420811,2
C--6755221(+) GCTAG-/ACACACA 1 -- us2k10--------
rs775463471,2
F--6755246(+) TCTGCA/GAAGTA 1 -- us2k11Minor allele frequency- G:0.03NA 120
rs1830451451,2
--6755279(+) ATGGCA/GCTATA 1 -- us2k10--------
rs1876933121,2
--6755289(+) ATATCC/TACAGA 1 -- us2k10--------

HapMap Linkage Disequilibrium report for ALOX12P2 (6757180 - 6857426 bp)

Structural Variations
     Database of Genomic Variants (DGV) 6 variations for ALOX12P2:    About this table    
Variant IDTypeSubtypePubMed ID
esv2715590CNV Deletion23290073
esv2422288CNV Deletion17116639
nsv521515CNV Loss19592680
esv21524CNV Loss19812545
nsv907630CNV Gain21882294
nsv518777CNV Gain19592680

Site Specific Mutation Identification with PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for ALOX12P2 gene integrated from 10 sources:
(articles sorted by number of sources associating them with ALOX12P2)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Cloning of a human &quot;epidermal-type&quot; 12-lipoxygenase-related gene and chromosomal localization to 17p13. (PubMed id 9691181)1, 3 Sun D....Funk C.D. (Cytogenet. Cell Genet. 1998)
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  3. Characterization of human 12-lipoxygenase genes. (PubMed id 1570320)1 Funk C.D.... Samuelsson B. (Proc. Natl. Acad. Sci. U.S.A. 1992)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 245 HGNC: 432 AceView: ALOX12P2 Ensembl:ENSG00000262943 euGenes: HUgn245
ECgene: ALOX12P2 H-InvDB: ALOX12P2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for ALOX12P2 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for ALOX12P2 gene:
Search GeneIP for patents involving ALOX12P2

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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