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ALOX12B Gene

protein-coding GIFtS: 60

GC17M007916

arachidonate 12-lipoxygenase, 12R type
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
12R-LOX ^¹, ², ³
12R-lipoxygenase ^³
EC 1.13.11.- ^³

Descriptions
Epidermis-type lipoxygenase 12 ^², ³
arachidonate 12-lipoxygenase, 12R type ^²

External Ids
HGNC: 430¹
Entrez Gene: 242²
UniProtKB: O75342³
Ensembl: ENSG00000179477⁷

Search outside databases for aliases for ALOX12B gene

Previous GC identifers: GC17P008465 GC17M008847 GC17M007918 GC17M008176

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for ALOX12B:

This gene encodes an enzyme involved in the converstion of arachidonic acid to

12R-hydroxyeicosatetraenoic acid. Mutations in this gene are associated with nonbullous congenital

ichthyosiform erythroderma. [provided by RefSeq]

UniProtKB/Swiss-Prot: LX12B_HUMAN, O75342

Function: Converts arachidonic acid to 12R-hydroperoxyeicosatetraenoic acid (12R-HPETE)

Gene Wiki entry for ALOX12B

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ALOX12B gene

Entrez Gene cytogenetic band: 17p13.1 Ensembl cytogenetic band: 17p13.1 HGNC cytogenetic band: 17p13.1

ALOX12B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17M007916: (about GC identifiers)

Start:	7,916,679 bp from pter
End:	7,931,746 bp from pter
Size:	15,068 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000017.9 NT_010718.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: LX12B_HUMAN, O75342 (See protein sequence)

Recommended Name: Arachidonate 12-lipoxygenase, 12R type

Size: 701 amino acids; 80356 Da

Cofactor: Binds 1 iron ion per subunit (By similarity)

REFSEQ proteins: NP_001130.1

ENSEMBL proteins:

ENSP00000315167

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
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	Browse R&D Systems for human recombinant proteins
	Enzo Life Sciences proteins for ALOX12B
	Browse Abcam for Recombinant Proteins
	Human Recombinant Proteins from Abnova (ALOX12B)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

Antibodies for ALOX12B:

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	Monoclonal and Polyclonal Antibodies from Abnova (ALOX12B)
	Novus Biologicals Antibodies for ALOX12B

Assays for ALOX12B:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry O75342

ProtoNet protein and cluster: O75342

3 Blocks protein families:

IPB000907 Lipoxygenase

IPB001024 Lipoxygenase

IPB001885 Mammalian lipoxygenase signature

UniProtKB/Swiss-Prot: LX12B_HUMAN, O75342

Similarity: Belongs to the lipoxygenase family

Similarity: Contains 1 lipoxygenase domain

Similarity: Contains 1 PLAT domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ALOX12B)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ALOX12B)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001139

Applied Biosystems Silencer® siRNAs for ALOX12B

Sigma-Aldrich siRNA and siRNA Panels for ALOX12B

Sigma-Aldrich shRNA for ALOX12B

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ALOX12B
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001139
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001139
untagged cDNA clone in CMV expression vector: NM_001139

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001139

UniProtKB/Swiss-Prot: LX12B_HUMAN, O75342

Function: Converts arachidonic acid to 12R-hydroperoxyeicosatetraenoic acid (12R-HPETE)

Enzyme Number (IUBMB): EC 1.13.11.-

4 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Alox12b):

homeostasis/metabolism

lethality-prenatal/perinatal

no phenotypic analysis

skin/coat/nails

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004052	arachidonate 12-lipoxygenase activity	TAS	9618483
GO:0005506	iron ion binding	IEA	--
GO:0016165	lipoxygenase activity	IEA	--
GO:0016491	oxidoreductase activity	IEA	--
GO:0046872	metal ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

3 Sigma-Aldrich "Your Favorite Gene" Pathways for ALOX12B (Your Favorite Gene powered by Ingenuity)

Linoleic Acid Metabolism
Eicosanoid Signaling
Arachidonic Acid Metabolism

GeneDecks ALOX12B for the pathways selected above

About GeneDecksing

UniProtKB/Swiss-Prot: LX12B_HUMAN, O75342

Pathway: Lipid metabolism; leukotriene D4 biosynthesis

4 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006629	lipid metabolic process	TAS	9618483
GO:0008544	epidermis development	TAS	9618483
GO:0019370	leukotriene biosynthetic process	IEA	--
GO:0055114	oxidation reduction	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Enzo Life Sciences drugs & compounds for ALOX12B

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ALOX12B
2 Novoseek chemical compound relationships for ALOX12B gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
12(r)-hpete	98.04	3	15629692 (1), 11368351 (1), 18086569 (1)
arachidonic acid	48.18	1	17436029 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ALOX12B)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ALOX12B)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001139

Sigma-Aldrich siRNA and siRNA Panels for ALOX12B

Sigma-Aldrich shRNA for ALOX12B

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001139

REFSEQ mRNAs for ALOX12B gene:

NM_001139.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001139

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001139
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001139
                                 untagged cDNA clone in CMV expression vector: NM_001139

Additional cDNA sequence:

AF038461.1 AF059250.1 BC041058.1

6 DOTS entries:

DT.91785069 DT.97792515 DT.97826992 DT.100695991 DT.102821098 DT.97791482

15 AceView cDNA sequences:

AF038461 AF059250 BX348205 NM_001139 BC041058 BX095379 BI667266 BG436629

BG698713 BX331920 BE715737 BM727907 BG946103 AA649213 BM563254

highest scoring ESTs for ALOX12B:

AF059250 AF038461 BC041058 BM563254 AA649213 BE715737 BG698713 BI667266 NM_001139 BG436629

Unigene Cluster for ALOX12B:

Arachidonate 12-lipoxygenase, 12R type

Hs.136574 [show with all ESTs]

Unigene Representative Sequence: NM_001139

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for ALOX12B

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9
SP1:
SP2:
SP3:					-

About this scheme

ECgene alternative splicing isoforms for ALOX12B

1 Ensembl transcript including schematic representation:

ENST00000319144

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ALOX12B expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ALOX12B

¹ / ² / ³

3 probe-sets matching ALOX12B gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
33029_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	AF059250	1.00	1.00	1.00	1
207381_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_001139	0.60	1.00	0.82	1
207381_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GACACGTTGC

SOURCE GeneReport for Unigene cluster: Hs.136574
Expression variation in blood from EXPOLDB for ALOX12B
UniProtKB/Swiss-Prot: LX12B_HUMAN, O75342
Tissue specificity: Expressed in B-cells, hair follicles, foreskin keratinocytes and adult skin.
Also expressed in psoriatic tissue

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ALOX12B gene from 5 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ALOX12B¹	--	arachidonate 12-lipoxygenase, 12R type	88.17(n) 88.41(a)	489486 XM_546604.2 XP_546604.2
chimpanzee (Pan troglodytes)	ALOX12B¹	--	arachidonate 12-lipoxygenase, 12R type	99.62(n) 99.71(a)	455103 XM_511864.2 XP_511864.2
cow (Bos taurus)	ALOX12B¹	--	arachidonate 12-lipoxygenase, 12R type	88.32(n) 88.41(a)	504803 XM_580977.2 XP_580977.2
rat (Rattus norvegicus)	Alox12b¹	--	arachidonate 12-lipoxygenase, 12R type	84.59(n) 86.59(a)	287425 NM_001039377.1 NP_001034466.1
mouse (Mus musculus)	Alox12b^{1, 5}	11 (37.00 cM)⁵	arachidonate 12-lipoxygenase, 12R type^{1, 5}	84.21(n)¹ 86.02(a)¹	11686¹ NM_009659.2¹ NP_033789.1¹ AF059251⁵ AK019091⁵ (see all 9)

About this table Species with no ortholog for ALOX12B

ENSEMBL Gene Tree for ALOX12B

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ALOX12B gene

ALOX5² ALOXE3²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/112 NCBI SNPs in ALOX12B are shown (see all 112 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 75)

AB	SNP ID	Valid	Chr 17 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs2278635^1,2	A,C,F,H	7931640(+)	`TGACTA/GGGCCT`	1	--	ut5¹		7		NA EU EA WA	562
	rs4792199^1,2	A,C,F,H	7932843(+)	`TGATAT/CTGAGC`	1	--	ng3¹		8		EU EA WA	836
	rs3027309^1,2	C,F,H	7931814(+)	`AAGGGC/TGGATA`	1	--	ng3¹ tfbs³		8		NA EU EA WA	632
	rs8077661^1,2	C,F,H	7930131(+)	`ACGGCC/TGTTGG`	1	G/S	mis¹ ese³		4		EU EA WA	406
	rs9903712^1,2	C,H	7932353(+)	`AGAAGA/CCCAAA`	1	--	ng3¹		4		EU EA WA	416
	rs9889361^1,2	A,C	7916489(+)	`CTGGCC/TCAGAT`	1	--	ng5¹		0	--	--	--	--
--	rs9909784^1,2	C	7932055(+)	`GAGGGG/TAGGGG`	1	--	ng3¹		0	--	--	--	--
	rs3027308^1,2	A,C,F,H	7931444(+)	`GACAAG/AAGGTC`	1	L/L	syn¹ ese³		7		NA EU EA WA	562
	rs3027299^1,2	A,C,F,H,O	7929569(+)	`TAAATG/AGGATA`	1	--	int¹		11		EU EA WA NA	978
	rs8081718^1,2	A,C,F,H	7921507(+)	`TGCCTT/CCTCTG`	1	--	int¹		7		EU EA WA NA	558

About this table

HapMap Linkage Disequilibrium images for ALOX12B (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 603741 disorders: 242100

UniProtKB/Swiss-Prot: LX12B_HUMAN, O75342

Defects in ALOX12B are a cause of non-bullous congenital ichthyosiform erythroderma (NCIE)

[MIM:242100]. NCIE is a non-bullous ichthyosis, a skin disorder characterized by abnormal

cornification of the epidermis. Most affected individuals are born with a tight, shiny,

translucent covering called collodion membrane. The collodion membrane subsequently evolves into

generalized scaling and intense redness of the skin. Clinical features are milder than in lamellar

ichthyoses and demonstrate a greater variability in the intensity of erythema, size and type of

scales. In contrast to lamellar ichthyoses, scales are usually white, fine and powdery, and palms

and soles are severely affected. Patients suffer from palmoplantar keratoderma, often with painful

fissures, digital contractures, and loss of pulp volume

5 Novoseek disease relationships for ALOX12B gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
ichthyosiform erythroderma nonbullous congenital	95.92	2	16792775 (1), 18347291 (1)
congenital ichthyosis	90.33	7	17139268 (2), 18086569 (1), 19122646 (1)
ichthyosiform erythroderma congenital	89.91	4	11773004 (2), 15629692 (1), 17139268 (1)
ichthyosis	88.80	6	18086569 (1), 19122646 (1), 17436029 (1), 18341575 (1)
skin diseases	40.04	1	15086555 (1)

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GeneTests: ALOX12B

Autosomal Recessive Congenital Ichthyosis

Human Gene Mutation Database: ALOX12B
Human Genome Epidemiology Navigator: ALOX12B (5 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/31 PubMed articles for ALOX12B gene (see all 31 ):

A 12R-lipoxygenase in human skin: mechanistic evidence, molecular cloning, and expression. (PubMed id 9618483)^{1, 2, 3, 4} Boeglin W.E.... Brash A.R. (1998)
A gene cluster encoding human epidermis-type lipoxygenases at chromosome 17p13.1: cloning, physical mapping, and expression. (PubMed id 11350124)^{1, 3, 4} Krieg P.... Fuerstenberger G. (2001)
Lipoxygenase-3 (ALOXE3) and 12(R)-lipoxygenase (ALOX12B) are mutated in non-bullous congenital ichthyosiform erythroderma (NCIE) linked to chromosome 17p13.1. (PubMed id 11773004)^{1, 3, 4} Jobard F.... Fischer J. (2002)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Human 12(R)-lipoxygenase and the mouse ortholog. Molecular cloning, expression, and gene chromosomal assignment. (PubMed id 9837935)^{3, 4} Sun D.... Funk C.D. (1998)
Mutations associated with a congenital form of ichthyosis (NCIE) inactivate the epidermal lipoxygenases 12R-LOX and eLOX3. (PubMed id 15629692)^{1, 3} Yu Z....Brash A.R. (2005)
Detection and cellular localization of 12R-lipoxygenase in human tonsils. (PubMed id 11368351)^{1, 3} Schneider C....Brash A.R. (2001)
Self-healing collodion membrane and mild nonbullous congenital ichthyosiform erythroderma due to 2 novel mutations in the ALOX12B gene. (PubMed id 18347291)^{1, 3} Harting M....Levy M.L. (2008)
Novel mutations in ALOX12B in patients with autosomal recessive congenital ichthyosis and evidence for genetic heterogeneity on chromosome 17p13. (PubMed id 17139268)^{1, 3} Lesueur F....Fischer J. (2007)
Epidermal lipoxygenase products of the hepoxilin pathway selectively activate the nuclear receptor PPARalpha. (PubMed id 17436029)^{1, 3} Yu Z....Brash A.R. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 242	HGNC: 430	AceView: ALOX12B	Ensembl:ENSG00000179477	euGenes: HUgn242
ECgene: ALOX12B	H-InvDB: ALOX12B

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
GeneReviews	http://www.genetests.org/query?gene=ALOX12B

Licensable Technologies for ALOX12B
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for ALOX12B:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ALOX12B-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ALOX12B		Antibodies for ALOX12B
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ALOX12B		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (ALOX12B)
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	Custom Service for Rabbit Pab from Full-length Protein

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	Drugs/Proteins for ALOX12B
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for ALOX12B

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ALOX12B Gene

protein-coding GIFtS: 60

Aliases &
Descriptions
for ALOX12B

Summaries
for ALOX12B

Genomic Location
for ALOX12B

Proteins
for ALOX12B

Protein Domains/
Families
for ALOX12B

Gene Function
for ALOX12B

Pathways & Interactions
for ALOX12B

Drugs & Compounds
for ALOX12B

Transcripts
for ALOX12B

Expression
for ALOX12B

Orthologs
for ALOX12B

Paralogs
for ALOX12B

SNPs/Variants
for ALOX12B

Disorders & Mutations
for ALOX12B

Medical News
for ALOX12B

Publications
for ALOX12B

Search for ALOX12B

Genome Databases showing ALOX12B

Other Databases showing ALOX12B

Specialized Databases showing ALOX12B

Licensable Technologies
for ALOX12B

Services
for ALOX12B

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ALOX12B Gene

protein-coding GIFtS: 60

Aliases & Descriptionsfor ALOX12B

Summariesfor ALOX12B

Genomic Locationfor ALOX12B

Proteinsfor ALOX12B

Protein Domains/Familiesfor ALOX12B

Gene Functionfor ALOX12B

Pathways & Interactionsfor ALOX12B

Drugs & Compoundsfor ALOX12B

Transcriptsfor ALOX12B

Expression for ALOX12B

Orthologsfor ALOX12B

Paralogsfor ALOX12B

SNPs/Variantsfor ALOX12B

Disorders & Mutationsfor ALOX12B

Medical Newsfor ALOX12B

Publicationsfor ALOX12B

Search for ALOX12B

Genome Databases showing ALOX12B

Other Databases showing ALOX12B

Specialized Databases showing ALOX12B

Licensable Technologiesfor ALOX12B

Servicesfor ALOX12B

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ALOX12B

Summaries
for ALOX12B

Genomic Location
for ALOX12B

Proteins
for ALOX12B

Protein Domains/
Families
for ALOX12B

Gene Function
for ALOX12B

Pathways & Interactions
for ALOX12B

Drugs & Compounds
for ALOX12B

Transcripts
for ALOX12B

Expression
for ALOX12B

Orthologs
for ALOX12B

Paralogs
for ALOX12B

SNPs/Variants
for ALOX12B

Disorders & Mutations
for ALOX12B

Medical News
for ALOX12B

Publications
for ALOX12B

Licensable Technologies
for ALOX12B

Services
for ALOX12B