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ALOX12 Gene

protein-coding GIFtS: 68

GC17P006840

arachidonate 12-lipoxygenase
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
12(S)-lipoxygenase ^²
12-LOX ^², ³
12S-LOX ^¹, ²
EC 1.13.11.31 ^³
LOG12 ^², ³

Descriptions
Platelet-type lipoxygenase 12 ^³
arachidonate 12-lipoxygenase ^²
platelet-type 12-lipoxygenase ^²

External Ids
HGNC: 429¹
Entrez Gene: 239²
UniProtKB: P18054³
Ensembl: ENSG00000108839⁷

Search outside databases for aliases for ALOX12 gene

Previous GC identifers: GC17P007287 GC17P007630 GC17P006741 GC17P007099

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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UniProtKB/Swiss-Prot: LOX12_HUMAN, P18054

Function: Oxygenase and 14,15-leukotriene A4 synthase activity

Gene Wiki entry for ALOX12

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ALOX12 gene

Entrez Gene cytogenetic band: 17p13.1 Ensembl cytogenetic band: 17p13.1 HGNC cytogenetic band: 17p13.1

ALOX12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P006840: (about GC identifiers)

Start:	6,840,108 bp from pter
End:	6,854,779 bp from pter
Size:	14,672 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000017.9 NT_010718.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: LOX12_HUMAN, P18054 (See protein sequence)

Recommended Name: Arachidonate 12-lipoxygenase, 12S-type

Size: 663 amino acids; 75694 Da

Cofactor: Binds 1 iron ion per subunit

Subcellular location: Cytoplasm

PDB structure from and Proteopedia :

2ABU (3D)

3D3L (3D)

Secondary accessions: O95569 Q6ISF8 Q9UQM4

REFSEQ proteins: NP_000688.2

ENSEMBL proteins:

ENSP00000251535 ENSP00000384466

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Enzo Life Sciences proteins for ALOX12
	Recombinant Proteins from Abcam (12 Lipoxygenase)
	Human Recombinant Proteins from Abnova (ALOX12)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--
GO:0005829	cytosol	IDA	15107407
GO:0042383	sarcolemma	IDA	15107407

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Antibodies for ALOX12:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for ALOX12
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (12 Lipoxygenase), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ALOX12)
	Novus Biologicals Antibodies for ALOX12

Assays for ALOX12:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P18054

ProtoNet protein and cluster: P18054

3 Blocks protein families:

IPB000907 Lipoxygenase

IPB001024 Lipoxygenase

IPB001885 Mammalian lipoxygenase signature

UniProtKB/Swiss-Prot: LOX12_HUMAN, P18054

Similarity: Belongs to the lipoxygenase family

Similarity: Contains 1 lipoxygenase domain

Similarity: Contains 1 PLAT domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ALOX12)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ALOX12)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000697

Applied Biosystems Silencer® siRNAs for ALOX12

Sigma-Aldrich siRNA and siRNA Panels for ALOX12

Sigma-Aldrich shRNA Panels and shRNA for ALOX12

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ALOX12
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000697
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000697
untagged cDNA clone in CMV expression vector: NM_000697

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000697

UniProtKB/Swiss-Prot: LOX12_HUMAN, P18054

Function: Oxygenase and 14,15-leukotriene A4 synthase activity

Catalytic activity: Arachidonate + O(2) =

(5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate

Enzyme Number (IUBMB): EC 1.13.11.31

Genatlas biochemistry entry for ALOX12:

arachidonate-12-lipoxygenase,75kDa,lipid peroxidating enzyme implicated in the pathogenesis of

inflammatory disorders as well as membrane remodeling,carcinogenesis,and atheroma

formation,expressed in platelets erythroleukemia cells and umbilical vein endothelial cells,also

in B cells and adult skin

4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Alox12):

hematopoietic system

homeostasis/metabolism

immune system

skin/coat/nails

5/7 Gene Ontology (GO) molecular function terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004052	arachidonate 12-lipoxygenase activity	IDA	2217179 2377602
GO:0005506	iron ion binding	IEA	--
GO:0005515	protein binding	IPI	10727209
GO:0016165	lipoxygenase activity	IEA	--
GO:0016491	oxidoreductase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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4 Sigma-Aldrich "Your Favorite Gene" Pathways for ALOX12 (Your Favorite Gene powered by Ingenuity)

Linoleic Acid Metabolism
Eicosanoid Signaling
Arachidonic Acid Metabolism
IL-12 Signaling and Production in Macrophages

GeneDecks ALOX12 for the pathways selected above

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UniProtKB/Swiss-Prot: LOX12_HUMAN, P18054

Pathway: Lipid metabolism; leukotriene D4 biosynthesis

Gene Network Central^TM Interacting Genes and Proteins Network for ALOX12

5/44 Interacting proteins for ALOX12 (P18054^{1, 2} ENSP00000251535³) via UniProtKB, MINT, and/or STRING (see all 44 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PLA2G2A	P14555², ENSP00000364252³	MINT-50574 STRING (score=.963)
TRIB1	Q96RU8¹, ENSP00000312150³	EBI-1633210, EBI-492555 STRING (score=.81)
KRT5	P13647¹, ENSP00000252242³	EBI-1633210, EBI-702187 STRING (score=.721)
ITGB4	P16144¹	EBI-1633210, EBI-948678
LMNA	P02545¹	EBI-1633210, EBI-351935

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5/10 Gene Ontology (GO) biological process terms (links to tree view) (see all 10 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006800	oxygen and reactive oxygen species metabolic process	NAS	12858336
GO:0006916	anti-apoptosis	ISS	--
GO:0006928	cell motion	IMP	14669797
GO:0008284	positive regulation of cell proliferation	ISS	--
GO:0019370	leukotriene biosynthetic process	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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Enzo Life Sciences drugs & compounds for ALOX12

Sigma-Aldrich Small Molecules for ALOX12:

Inhibitor

Compounds for ALOX12 available from Tocris Bioscience

Compound	Action	CAS number
2-TEDC	5-, 12-, 15-Lipoxygenase inhibitor	[132465-10-2]
Baicalein	5- and 12-Lipoxygenase inhibitor	[491-67-8]

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10/45 Novoseek chemical compound relationships for ALOX12 gene (see all 45 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
12-hydroxyeicosatetraenoic acid	96.26	115	10588925 (4), 16514435 (3), 14518561 (3), 17522976 (2) (see all 50)
bhpp	91.55	11	10733500 (2), 7593207 (1), 7540838 (1), 9174106 (1) (see all 7)
arachidonic acid	90.96	208	8829479 (4), 11115402 (4), 19235890 (3), 14518561 (3) (see all 99)
n-benzyl-n-hydroxy-5-phenylpentamide	90.82	4	12874035 (1), 10861450 (1), 11980674 (1)
baicalein	90.46	53	19439216 (4), 17050058 (4), 17263456 (2), 12874035 (1) (see all 28)
hepoxilin b3	89.63	5	10692117 (3), 2180942 (1), 11851887 (1)
hepoxilin a3	87.30	4	2106877 (2), 12432937 (1)
12(s)-hydroperoxyeicosatetraenoic acid	84.86	3	8188678 (1), 10588925 (1), 16638750 (1)
13-hydroperoxyoctadecadienoic acid	82.14	2	12218361 (1), 10882192 (1)
boswellic acids	74.50	4	17945191 (1), 16788089 (1), 8510458 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ALOX12)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ALOX12)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000697

Sigma-Aldrich siRNA and siRNA Panels for ALOX12

Sigma-Aldrich shRNA Panels and shRNA for ALOX12

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000697

REFSEQ mRNAs for ALOX12 gene:

NM_000697.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000697

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000697
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000697
                                 untagged cDNA clone in CMV expression vector: NM_000697

Additional cDNA sequence:

AF143883.1 BC069557.1 M35418.1 M58704.1 M62982.1 S68587.1 S68588.1

3 DOTS entries:

DT.209219 DT.100019329 DT.91754446

16 AceView cDNA sequences:

AF143883 S68587 M58704 NM_000697 M62982 BC069557 M35418 BG900221

BI044580 AW374333 T63474 BF773448 BV184224 T97387 T63549 T97276

highest scoring ESTs for ALOX12:

M62982 AF143883 BC069557 M35418 M58704 T63549 T97276 BF738637 BF773448 BI044580

Unigene Cluster for ALOX12:

Arachidonate 12-lipoxygenase

Hs.654431 [show with all ESTs]

Unigene Representative Sequence: NM_000697

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:

ENST00000251535 ENST00000406228

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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ALOX12 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ALOX12

¹ / ² / ³

3 probe-sets matching ALOX12 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
35124_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	M62982	1.00	1.00	1.00	1
207206_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000697	0.60	1.00	0.82	1
207206_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks ALOX12 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GAAATGAGTG

SOURCE GeneReport for Unigene cluster: Hs.654431
Expression variation in blood from EXPOLDB for ALOX12

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ALOX12 gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ALOX12¹	--	arachidonate 12-lipoxygenase	87.03(n) 85.52(a)	479476 XM_851445.1 XP_856538.1
chimpanzee (Pan troglodytes)	ALOX12¹	--	arachidonate 12-lipoxygenase	95.23(n) 93.76(a)	455242 XM_511984.2 XP_511984.2
cow (Bos taurus)	ALOX12¹	--	arachidonate 12-lipoxygenase	88.89(n) 87.33(a)	407169 XM_590488.3 XP_590488.2
rat (Rattus norvegicus)	Alox12¹	--	arachidonate 12-lipoxygenase	85.02(n) 84.46(a)	287454 XM_213369.4 XP_213369.4
mouse (Mus musculus)	Alox12^{1, 5}	11 (40.00 cM)⁵	arachidonate 12-lipoxygenase^{1, 5}	85.42(n)¹ 85.52(a)¹	11684¹ NM_007440.3¹ NP_031466.2¹ AK036898⁵ AK036960⁵ (see all 21)

About this table Species with no ortholog for ALOX12

ENSEMBL Gene Tree for ALOX12

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ALOX12 gene

ALOX12P2² ALOX15B² ALOX15²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/145 NCBI SNPs in ALOX12 are shown (see all 145 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 70)

AB	SNP ID	Valid	Chr 17 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1126667^1,2	A,C,F,H	6843484(+)	`GCTTCG/AGGCTC`	1	R/Q	mis¹ ese³		22	NA MN CSAM EA NS EU WA	1754
	rs312466^1,2	A,C,F,H	6839945(+)	`CAGGAG/AGCACA`	1	--	ng5¹		10	NS MN EU EA NA	888
	rs434473^1,2	C,F,H	6845658(+)	`TCCCAA/GCCCCA`	1	N/S	mis¹ ese³		18	EA NA NS MN EU WA	2476
--	rs9904779^1,2	A,C,F	6839339(+)	`GTGTTG/CCTGGG`	1	--	ng5¹		2	NS	78
	rs11571357^1,2	C,F,H	6839046(+)	`TGCAGC/TAGGCT`	1	--	ng5¹		9	NS EU EA WA NA	638
--	rs3840880^1,2	C,F	6838568(-)	`GCCTA-/GAAAAG`	1	--	ng5¹		2	NS	88
	rs11571326^1,2	C,F	6839621(+)	`TAGCCG/ACGGGA`	1	--	ng5¹		3	NS NA	142
	rs9897850^1,2	C,F	6839842(+)	`TCGATC/TCCGCC`	1	--	ng5¹		3	NS NA	140
--	rs11571325^1,2	F	6839319(+)	`CACCC-/TTAACA`	1	--	ng5¹		2	NS	94
	rs11571342^1,2	H	6849941(+)	`GCTCCG/ATCGGG`	1	H/R	mis¹ ese³		6	NS EU EA WA	492

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HapMap Linkage Disequilibrium images for ALOX12 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 152391

10/40 Novoseek disease relationships for ALOX12 gene (see all 40 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
erythroleukemia	59.96	10	10830714 (2), 2244907 (2), 8443239 (2), 8295977 (1) (see all 7)
carcinoma squamous cell	42.92	19	10428482 (2), 9174106 (2), 9443600 (2), 7525931 (1) (see all 13)
prostate cancer	36.61	54	7624992 (5), 11980674 (5), 10818452 (4), 9321930 (4) (see all 15)
prostate carcinoma	35.97	7	14669797 (3), 10667391 (1), 17443494 (1), 10861450 (1) (see all 5)
atherosclerosis	32.65	6	17459368 (1), 18296557 (1), 10504415 (1), 11845232 (1) (see all 6)
cancer	30.59	24	12874035 (3), 7825842 (1), 15034803 (1), 16731771 (1) (see all 16)
tumors	27.58	77	10861450 (4), 14669797 (4), 10818452 (3), 12085962 (3) (see all 35)
skin tumor	26.11	3	15305153 (2), 10667390 (1)
psoriasis	24.80	9	17521953 (2), 8304420 (1), 16019177 (1), 18755188 (1) (see all 5)
metastasis	22.24	26	14669797 (3), 7712597 (2), 12394183 (2), 7825842 (1) (see all 15)

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Human Gene Mutation Database: ALOX12
Genetic Association Database: ALOX12
Human Genome Epidemiology Navigator: ALOX12 (16 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/334 PubMed articles for ALOX12 gene (see all 334 ):

Arachidonate lipoxygenase (ALOX) and cyclooxygenase (COX) polymorphisms and colon cancer risk. (PubMed id 15308583)^{3, 4, 6} Goodman J.E.... Harris C.C. (2004)
Characterization of human 12-lipoxygenase genes. (PubMed id 1570320)^{2, 3, 4} Funk C.D.... Samuelsson B. (1992)
Cloning of the cDNA for human 12-lipoxygenase. (PubMed id 2217179)^{1, 3, 4} Izumi T.... Samuelsson B. (1990)
Epidermis contains platelet-type 12-lipoxygenase that is overexpressed in germinal layer keratinocytes in psoriasis. (PubMed id 8304420)^{1, 3, 4} Hussain H.... Holtzman M.J. (1994)
Molecular cloning and expression of human arachidonate 12- lipoxygenase. (PubMed id 2244907)^{1, 3, 4} Yoshimoto T.... Toh H. (1990)
Structure and chromosomal localization of human arachidonate 12- lipoxygenase gene. (PubMed id 1447217)^{1, 3, 4} Yoshimoto T.... Takahashi E. (1992)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Association of a new polymorphism in ALOX12 gene with bipolar disorder. (PubMed id 12664313)^{3, 6} Fridman C....Dias Neto E. (2003)
Molecular cloning, primary structure, and expression of the human platelet/erythroleukemia cell 12-lipoxygenase. (PubMed id 2377602)^{3, 4} Funk C.D.... Fitzgerald G.A. (1990)
Increased metastatic potential in human prostate carcinoma cells by overexpression of arachidonate 12-lipoxygenase. (PubMed id 14669797)^{1, 3} Nie D....Honn K.V. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 239	HGNC: 429	AceView: ALOX12	Ensembl:ENSG00000108839	euGenes: HUgn239
ECgene: ALOX12	H-InvDB: ALOX12

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for ALOX12	Genetics and Cytogenetics in Oncology and Haematology
SeattleSNPs	http://pga.gs.washington.edu/data/alox12/

Licensable Technologies for ALOX12
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ALOX12:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ALOX12-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ALOX12		Antibodies for ALOX12
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ALOX12		Small molecules for ALOX12
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (ALOX12)
	Antibodies (ALOX12)
	Chimera RNAi (ALOX12)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (12 Lipoxygenase)
	Antibodies (12 Lipoxygenase)

Search OriGene for ALOX12

Tocris compounds for ALOX12

	Drugs/Proteins for ALOX12
	Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for ALOX12

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ALOX12 Gene

protein-coding GIFtS: 68

Aliases &
Descriptions
for ALOX12

Summaries
for ALOX12

Genomic Location
for ALOX12

Proteins
for ALOX12

Protein Domains/
Families
for ALOX12

Gene Function
for ALOX12

Pathways & Interactions
for ALOX12

Drugs & Compounds
for ALOX12

Transcripts
for ALOX12

Expression
for ALOX12

Orthologs
for ALOX12

Paralogs
for ALOX12

SNPs/Variants
for ALOX12

Disorders & Mutations
for ALOX12

Medical News
for ALOX12

Publications
for ALOX12

Search for ALOX12

Genome Databases showing ALOX12

Other Databases showing ALOX12

Specialized Databases showing ALOX12

Licensable Technologies
for ALOX12

Services
for ALOX12

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ALOX12 Gene

protein-coding GIFtS: 68

Aliases & Descriptionsfor ALOX12

Summariesfor ALOX12

Genomic Locationfor ALOX12

Proteinsfor ALOX12

Protein Domains/Familiesfor ALOX12

Gene Functionfor ALOX12

Pathways & Interactionsfor ALOX12

Drugs & Compoundsfor ALOX12

Transcriptsfor ALOX12

Expression for ALOX12

Orthologsfor ALOX12

Paralogsfor ALOX12

SNPs/Variantsfor ALOX12

Disorders & Mutationsfor ALOX12

Medical Newsfor ALOX12

Publicationsfor ALOX12

Search for ALOX12

Genome Databases showing ALOX12

Other Databases showing ALOX12

Specialized Databases showing ALOX12

Licensable Technologiesfor ALOX12

Servicesfor ALOX12

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ALOX12

Summaries
for ALOX12

Genomic Location
for ALOX12

Proteins
for ALOX12

Protein Domains/
Families
for ALOX12

Gene Function
for ALOX12

Pathways & Interactions
for ALOX12

Drugs & Compounds
for ALOX12

Transcripts
for ALOX12

Expression
for ALOX12

Orthologs
for ALOX12

Paralogs
for ALOX12

SNPs/Variants
for ALOX12

Disorders & Mutations
for ALOX12

Medical News
for ALOX12

Publications
for ALOX12

Licensable Technologies
for ALOX12

Services
for ALOX12