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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ALOX12 Gene

protein-coding   GIFtS: 67
GCID: GC17P006899

Arachidonate 12-Lipoxygenase

Alzheimer's & Parkinson's Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Arachidonate 12-Lipoxygenase1 2     12(S)-lipoxygenase2
Platelet 12-LOX1 2     12-LOX2
Platelet-Type Lipoxygenase 122 3     Arachidonate 12-Lipoxygenase, 12S-Type2
12S-LOX2 3     Platelet-Type 12-Lipoxygenase2
12S-lipoxygenase2 3     EC 1.13.11.313
LOG122 3     EC 1.13.118

External Ids:    HGNC: 4291   Entrez Gene: 2392   Ensembl: ENSG000001088397   OMIM: 1523915   UniProtKB: P180543   

Export aliases for ALOX12 gene to outside databases

Previous GC identifers: GC17P007287 GC17P007630 GC17P006741 GC17P007099 GC17P006840


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ALOX12 Gene: 
ALOX12 (arachidonate 12-lipoxygenase) is a protein-coding gene. Diseases associated with ALOX12 include essential thrombocythemia, and atherosclerosis, and among its related super-pathways are Arachidonic acid metabolism and Metabolic pathways. GO annotations related to this gene include arachidonate 12-lipoxygenase activity and iron ion binding. An important paralog of this gene is ALOX12B.

UniProtKB/Swiss-Prot: LOX12_HUMAN, P18054
Function: Oxygenase and 14,15-leukotriene A4 synthase activity

summary for ALOX12 Gene:
Lipoxygenases (LOXs) are a family of non-heme iron dioxygenases that are involved in the production and
metabolism of fatty acid hydroperoxidases. There are six lipoxygenase isozymes; 5-LOX, 12R-LOX, 12S-LOX,
15-LOX-1 and 15-LOX-2, which catalyze the regio-selective addition of oxygen into arachidonic acid, and
epidermal LOX (E-LOX) which metabolizes 12R-hydroperoxyeicosatetraenoic acid (12R-HPETE) to a specific
epoxyalcohol compound. Different isozymes have different physiological roles; 5-, 12R-, 12S- and 15-LOX-1
have proliferative, antiapoptotic and angiogenic functions whilst 15-LOX-2 has roles in differentiation,
growth arrest and the induction of apoptosis. E-LOX, the most divergent member of this family, is involved
in terminal differentiation of keratinocytes and has a major role in skin barrier function. Perturbations in
lipoxygenase enzymes have been implicated in various human diseases including bronchial asthma,
atherosclerosis, osteoporosis and some cancers.

Gene Wiki entry for ALOX12 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010718.16  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ALOX12 gene promoter:
         AML1a   Lmo2   Nkx2-5   YY1   FOXL1   Zic1   ZIC2/Zic2   LyF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidALOX12 promoter sequence
   Search SABiosciences Chromatin IP Primers for ALOX12

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ALOX12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.1   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p13.1

ALOX12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ALOX12 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P006899:  view genomic region     (about GC identifiers)

Start:
6,899,384 bp from pter      End:
6,914,055 bp from pter
Size:
14,672 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: LOX12_HUMAN, P18054 (See protein sequence)
Recommended Name: Arachidonate 12-lipoxygenase, 12S-type  
Size: 663 amino acids; 75694 Da
Cofactor: Binds 1 iron ion per subunit
Subcellular location: Cytoplasm
2 PDB 3D structures from and Proteopedia for ALOX12:
2ABU (3D)        3D3L (3D)    
Secondary accessions: O95569 Q6ISF8 Q9UQM4

Explore the universe of human proteins at neXtProt for ALOX12: NX_P18054

Explore proteomics data for ALOX12 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P18054

  • 3 DME Specific Peptides for ALOX12 (P18054)
     CPPDDLA  WVPNAPCTMR  GMEELQAQLEKEL 

    ALOX12 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ALOX12 Protein Expression
    REFSEQ proteins: NP_000688.2  
    ENSEMBL proteins: 
     ENSP00000251535   ENSP00000467033  
    Reactome Protein details: P18054
    Human Recombinant Protein Products for ALOX12: 
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    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ALOX12 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA8319693
    GO:0005829cytosol TAS--
    GO:0016020membrane IDA8912711
    GO:0042383sarcolemma IDA15107407

    ALOX12 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ALOX: Arachidonate lipoxygenases

    IUPHAR Guide to PHARMACOLOGY protein family classification: 12S-LOX 
    Lipoxygenases

    5/7 InterPro protein domains (see all 7):
     IPR020833 LipOase_Fe_BS
     IPR013819 LipOase_C
     IPR001024 LipOase_LH2
     IPR008976 Lipase_LipOase
     IPR020834 LipOase_CS

    Graphical View of Domain Structure for InterPro Entry P18054

    ProtoNet protein and cluster: P18054

    3 Blocks protein domains:
    IPB000907 Lipoxygenase
    IPB001024 Lipoxygenase
    IPB001885 Mammalian lipoxygenase signature


    UniProtKB/Swiss-Prot: LOX12_HUMAN, P18054
    Similarity: Belongs to the lipoxygenase family
    Similarity: Contains 1 lipoxygenase domain
    Similarity: Contains 1 PLAT domain


    ALOX12 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LOX12_HUMAN, P18054
    Function: Oxygenase and 14,15-leukotriene A4 synthase activity
    Catalytic activity: Arachidonate + O(2) = (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate

         Genatlas biochemistry entry for ALOX12:
    arachidonate-12-lipoxygenase,75kDa,lipid peroxidating enzyme implicated in the pathogenesis of inflammatory
    disorders as well as membrane remodeling,carcinogenesis,and atheroma formation,expressed in platelets
    erythroleukemia cells and umbilical vein endothelial cells,also in B cells and adult skin

         Enzyme Numbers (IUBMB): EC 1.13.11.311 EC 1.13.112

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004052arachidonate 12-lipoxygenase activity TAS--
    GO:0005506iron ion binding IEA--
    GO:0005515protein binding IPI10727209
    GO:0016165linoleate 13S-lipoxygenase activity IDA8319693
    GO:0016702oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen TAS--
         
    ALOX12 for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Alox12):
     hematopoietic system  homeostasis/metabolism  immune system  integument 

    ALOX12 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Alox12tm1Fun for ALOX12

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ALOX12 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ALOX12

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ALOX12 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ALOX12 

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidALOX12 3' UTR sequence
    Inhib. RNA
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALOX12


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ALOX12 About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Arachidonic acid metabolism
    Arachidonic acid metabolism0.44
    HETE and HPETE biosynthesis and metabolism0.35
    Arachidonic acid metabolism0.44
    2Metabolism
    Metabolism0.40
    Metabolism of lipids and lipoproteins0.34
    Metabolic pathways0.40
    3lipoxin biosynthesis
    lipoxin biosynthesis0.67
    Synthesis of Hepoxilins (HX) and Trioxilins (TrX)0.33
    4Synthesis of 15-eicosatetraenoic acid derivatives
    Synthesis of 12-eicosatetraenoic acid derivatives0.50
    Synthesis of Lipoxins (LX)0.33
    5Circadian entrainment
    Serotonergic synapse0.33

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for ALOX12
        HETE and HPETE biosynthesis and metabolism


    1 GeneGo (Thomson Reuters) Pathway for ALOX12
        HETE and HPETE biosynthesis and metabolism

    2 BioSystems Pathways for ALOX12
        Eicosanoid Synthesis
    lipoxin biosynthesis

    5/6        Reactome Pathways for ALOX12 (see all 6)
        Synthesis of Lipoxins (LX)
    Synthesis of Hepoxilins (HX) and Trioxilins (TrX)
    Metabolism
    Arachidonic acid metabolism
    Synthesis of 12-eicosatetraenoic acid derivatives


    3         Kegg Pathways  (Kegg details for ALOX12):
        Arachidonic acid metabolism
    Metabolic pathways
    Serotonergic synapse

    UniProtKB/Swiss-Prot: LOX12_HUMAN, P18054
    Pathway: Lipid metabolism; leukotriene D4 biosynthesis


    ALOX12 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ALOX12

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/47 Interacting proteins for ALOX12 (P180541, 2, 3 ENSP000002515354) via UniProtKB, MINT, STRING, and/or I2D (see all 47)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    LMNAP025451, 3, ENSP000003572834EBI-1633210,EBI-351935 I2D: score=4 STRING: ENSP00000357283
    PLA2G2AP145552, 3, ENSP000003642524MINT-50574 I2D: score=2 STRING: ENSP00000364252
    KRT5P136471, 3, ENSP000002522424EBI-1633210,EBI-702187 I2D: score=6 STRING: ENSP00000252242
    ITGB4P161443, ENSP000002001814I2D: score=4 STRING: ENSP00000200181
    KRT85P783863, ENSP000002579014I2D: score=1 STRING: ENSP00000257901
    About this table

    Gene Ontology (GO): 5/37 biological process terms (GO ID links to tree view) (see all 37):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006691leukotriene metabolic process ----
    GO:0006928cellular component movement IMP14669797
    GO:0007568aging IEA--
    GO:0008284positive regulation of cell proliferation ISS--
    GO:0010595positive regulation of endothelial cell migration IEA--

    ALOX12 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ALOX12 for compounds           About GeneDecksing

    EMD Millipore small molecules for ALOX12:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for ALOX12 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    BAY-X 1005Orally active 5-lipoxygenase activating protein (FLAP) inhibitor[128253-31-6]
    BW-B 70C5-Lipoxygenase inhibitor[134470-38-5]
    ZileutonOrally active 5-LOX inhibitor[111406-87-2]
    MK 886Inhibitor of 5-lipoxygenase-activating protein (FLAP)[118414-82-7]
    Baicalein5- and 12-Lipoxygenase inhibitor[491-67-8]

    4 HMDB Compounds for ALOX12    About this table
    CompoundSynonyms CAS #PubMed Ids
    12(S)-HPETE(5Z,8z,10e,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate (see all 7)71774-10-2--
    Arachidonic acid5,8,11,14-Eicosatetraenoic acid (see all 16)506-32-1--
    IronArmco iron (see all 19)7439-89-6--
    OxygenOxygen (see all 5)7782-44-7--

    10/81 Novoseek inferred chemical compound relationships for ALOX12 gene (see all 81)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    12-hydroxyeicosatetraenoic acid 96.3 125 10588925 (4), 16514435 (3), 14518561 (3), 17522976 (2) (see all 53)
    12-hpete 94.6 21 10830714 (1), 12848295 (1), 16828271 (1), 15474031 (1) (see all 17)
    bhpp 91.3 11 10733500 (2), 7593207 (1), 7540838 (1), 9174106 (1) (see all 7)
    arachidonic acid 91 216 8829479 (4), 11115402 (4), 19235890 (3), 14518561 (3) (see all 99)
    n-benzyl-n-hydroxy-5-phenylpentamide 90.6 4 12874035 (1), 10861450 (1), 11980674 (1)
    baicalein 90 55 19439216 (4), 17050058 (4), 17263456 (2), 12874035 (1) (see all 29)
    hepoxilin b3 89.4 5 10692117 (3), 2180942 (1), 11851887 (1)
    hepoxilin a3 87 4 2106877 (2), 12432937 (1)
    12(s)-hydroperoxyeicosatetraenoic acid 84.8 3 8188678 (1), 10588925 (1), 16638750 (1)
    13-hydroperoxyoctadecadienoic acid 81.7 2 12218361 (1), 10882192 (1)

    Search CenterWatch for drugs/clinical trials and news about ALOX12 / LOX12

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ALOX12 gene: 
    NM_000697.2  

    Unigene Cluster for ALOX12:

    Arachidonate 12-lipoxygenase
    Hs.654431  [show with all ESTs]
    Unigene Representative Sequence: NM_000697
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000251535(uc002gdx.4) ENST00000480801 ENST00000406228(uc002gdz.4)


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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ALOX12

    Additional mRNA sequence: 

    AF143883.1 BC069557.1 M35418.1 M58704.1 M62982.1 S68587.1 S68588.1 

    3 DOTS entries:

    DT.209219  DT.100019329  DT.91754446 

    16 AceView cDNA sequences:

    AF143883 S68587 NM_000697 M35418 M58704 M62982 BC069557 BG900221 
    BI044580 AW374333 T63474 BF773448 BV184224 T97387 T63549 T97276 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ALOX12 expression in normal human tissues (normalized intensities)      ALOX12 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAATGAGTG
    ALOX12 Expression
    About this image


    ALOX12 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Myoblasts Mandibular Arch Muscles
     
     Liver (Hepatobiliary System)
             Liver Lobule

    See ALOX12 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ALOX12

    SOURCE GeneReport for Unigene cluster: Hs.654431
        SABiosciences Expression via Pathway-Focused PCR Arrays including ALOX12: 
              Oxidative Stress in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              Apoptosis 384HT in human mouse rat
              Drug Metabolism in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALOX12

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ALOX12 gene from 2/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Alox121 , 5 arachidonate 12-lipoxygenase1, 5 85.42(n)1
    85.52(a)1
      11 (42.99 cM)5
    116841  NM_007440.41  NP_031466.21 
     702414575 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb72a112 wufb72a11 73.62(n)   322732  BC054621.1 


    ENSEMBL Gene Tree for ALOX12 (if available)
    TreeFam Gene Tree for ALOX12 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ALOX12 gene
    ALOX12B2  ALOX52  ALOX15B2  ALOXE32  ALOX152  
    6 SIMAP similar genes for ALOX12 using alignment to 2 protein entries:     LOX12_HUMAN (see all proteins):
    arachidonate 12-lipoxygenase    ALOX15    ALOX5    ALOX12B    ALOX15B    ALOXE3

    ALOX12 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for ALOX12
    PGOHUM00000237213 PGOHUM00000237343 PGOHUM00000262364


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    6 SNPs in ALOX12 are shown    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0304714
    ----see VAR_0304712 E K mis40--------
    VAR_0187434
    ----see VAR_0187432 Q R mis40--------
    VAR_0187454
    ----see VAR_0187452 R H mis40--------
    VAR_0042794
    ----see VAR_0042792 A T mis40--------
    VAR_0187444
    ----see VAR_0187442 N S mis40--------
    rs3727223241,2
    ----6791262(+) TAAAA-/TGGTTTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ALOX12 (6899384 - 6914055 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for ALOX12:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2422288CNV Deletion17116639
    esv1008363CNV Loss20482838
    nsv457659CNV Loss19166990
    nsv907633CNV Loss21882294
    nsv907634CNV Loss21882294


    Human Gene Mutation Database (HGMD): ALOX12
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ALOX12
    DNA2.0 Custom Variant and Variant Library Synthesis for ALOX12

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 152391    OMIM disorders: --

    20/54 diseases for ALOX12 (see all 54):    About MalaCards
    essential thrombocythemia    atherosclerosis    asthma    spinal cord injury
    hyperglycemia    thrombocytopenia    essential hypertension    vascular disease
    testicular cancer    prostate cancer, progression of    pancreatic cancer    ichthyosis
    psoriasis    colon adenocarcinoma    inflammatory bowel disease    prostate cancer
    esophageal adenocarcinoma    bladder carcinoma    prostate adenocarcinoma    oral cancer


    ALOX12 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/41 Novoseek inferred disease relationships for ALOX12 gene (see all 41)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    erythroleukemia 60.9 10 10830714 (2), 2244907 (2), 8443239 (2), 8295977 (1) (see all 7)
    carcinoma squamous cell 42.2 20 10428482 (2), 9174106 (2), 9443600 (2), 7525931 (1) (see all 14)
    prostate cancer 35.7 61 7624992 (5), 11980674 (5), 10818452 (4), 9321930 (4) (see all 16)
    prostate carcinoma 34.7 7 14669797 (3), 10667391 (1), 17443494 (1), 10861450 (1) (see all 5)
    atherosclerosis 32 6 17459368 (1), 18296557 (1), 10504415 (1), 11845232 (1) (see all 6)
    cancer 29.8 25 12874035 (3), 7825842 (1), 15034803 (1), 16731771 (1) (see all 17)
    tumors 27 78 10861450 (4), 14669797 (4), 10818452 (3), 12085962 (3) (see all 36)
    skin tumor 24.4 3 15305153 (2), 10667390 (1)
    metastasis 22.6 31 14669797 (3), 7712597 (2), 20303950 (2), 12394183 (2) (see all 16)
    psoriasis 22.5 9 17521953 (2), 8304420 (1), 16019177 (1), 18755188 (1) (see all 5)

    Genetic Association Database (GAD): ALOX12
    Human Genome Epidemiology (HuGE) Navigator: ALOX12 (36 documents)

    Export disorders for ALOX12 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ALOX12 gene, integrated from 9 sources (see all 403):
    (articles sorted by number of sources associating them with ALOX12)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Arachidonate lipoxygenase (ALOX) and cyclooxygenase (COX) polymorphisms and colon cancer risk. (PubMed id 15308583)1, 2, 4 Goodman J.E.... Harris C.C. (2004)
    2. Characterization of human 12-lipoxygenase genes. (PubMed id 1570320)1, 2, 3 Funk C.D.... Samuelsson B. (1992)
    3. Platelet 12-lipoxygenase Arg261Gln polymorphism: functional characterization and association with risk of esophageal squamous cell carcinoma in combination with COX-2 polymorphisms. (PubMed id 17460548)1, 4, 9 Guo Y....Lin D. (2007)
    4. Polymorphisms in ALOX12, but not ALOX15, are significantly associated with BMD in postmenopausal women. (PubMed id 17520163)1, 4, 9 Mullin B.H....Wilson S.G. (2007)
    5. Human ALOX12, but not ALOX15, is associated with BMD in white men and women. (PubMed id 16598376)1, 4, 9 Ichikawa S....Econs M.J. (2006)
    6. Cloning of the cDNA for human 12-lipoxygenase. (PubMed id 2217179)1, 2, 9 Izumi T.... Samuelsson B. (1990)
    7. A coding polymorphism in the 12-lipoxygenase gene is associated to essential hypertension and urinary 12(S)-HETE. (PubMed id 16514435)1, 4, 9 Quintana L.F....Poch E. (2006)
    8. Epidermis contains platelet-type 12-lipoxygenase that is overexpressed in germinal layer keratinocytes in psoriasis. (PubMed id 8304420)1, 2, 9 Hussain H.... Holtzman M.J. (1994)
    9. Molecular cloning and expression of human arachidonate 12- lipoxygenase. (PubMed id 2244907)1, 2, 9 Yoshimoto T.... Toh H. (1990)
    10. Association of arachidonate 12-lipoxygenase genotype variation and glycemic control with albuminuria in type 2 diabetes. (PubMed id 18640486)1, 4, 9 Liu Y....Rich S.S. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 239 HGNC: 429 AceView: ALOX12 Ensembl:ENSG00000108839 euGenes: HUgn239
    ECgene: ALOX12 Kegg: 239 H-InvDB: ALOX12

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ALOX12 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ALOX12 Genetics and Cytogenetics in Oncology and Haematology
    SeattleSNPshttp://pga.gs.washington.edu/data/alox12/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ALOX12 gene:
    Search GeneIP for patents involving ALOX12

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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