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Aliases for ALOX12 Gene

Aliases for ALOX12 Gene

  • Arachidonate 12-Lipoxygenase 2 3
  • Platelet-Type Lipoxygenase 12 3 4
  • Lipoxin Synthase 12-LO 3 4
  • 12S-Lipoxygenase 3 4
  • Platelet 12-LOX 2 3
  • 12S-LOX 3 4
  • LOG12 3 4
  • Arachidonate 12-Lipoxygenase, 12S-Type 3
  • Platelet-Type 12-Lipoxygenase 3
  • 12(S)-Lipoxygenase 3
  • EC 1.13.11.31 4
  • EC 1.13.11 63
  • EC 3.3.2.- 4
  • 12-LOX 3
  • 12LO 4

External Ids for ALOX12 Gene

Previous GeneCards Identifiers for ALOX12 Gene

  • GC17P007287
  • GC17P007630
  • GC17P006741
  • GC17P007099
  • GC17P006840
  • GC17P006899

Summaries for ALOX12 Gene

GeneCards Summary for ALOX12 Gene

ALOX12 (Arachidonate 12-Lipoxygenase) is a Protein Coding gene. Diseases associated with ALOX12 include essential thrombocythemia and atherosclerosis. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include iron ion binding and arachidonate 12-lipoxygenase activity. An important paralog of this gene is ALOX5.

UniProtKB/Swiss-Prot for ALOX12 Gene

  • Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Mainly converts arachidonic acid to (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE but can also metabolize linoleic acid. Has a dual activity since it also converts leukotriene A4/LTA4 into both the bioactive lipoxin A4/LXA4 and lipoxin B4/LXB4. Through the production of specific bioactive lipids like (12S)-HPETE it regulates different biological processes including platelet activation. It also probably positively regulates angiogenesis through regulation of the expression of the vascular endothelial growth factor. Plays a role in apoptotic process, promoting the survival of vascular smooth muscle cells for instance. May also play a role in the control of cell migration and proliferation.

Tocris Summary for ALOX12 Gene

  • Lipoxygenases (LOXs) are a family of non-heme iron dioxygenases that are involved in the production and metabolism of fatty acid hydroperoxidases. There are six lipoxygenase isozymes; 5-LOX, 12R-LOX, 12S-LOX, 15-LOX-1 and 15-LOX-2, which catalyze the regio-selective addition of oxygen into arachidonic acid, and epidermal LOX (E-LOX) which metabolizes 12R-hydroperoxyeicosatetraenoic acid (12R-HPETE) to a specific epoxyalcohol compound. Different isozymes have different physiological roles; 5-, 12R-, 12S- and 15-LOX-1 have proliferative, antiapoptotic and angiogenic functions whilst 15-LOX-2 has roles in differentiation, growth arrest and the induction of apoptosis. E-LOX, the most divergent member of this family, is involved in terminal differentiation of keratinocytes and has a major role in skin barrier function. Perturbations in lipoxygenase enzymes have been implicated in various human diseases including bronchial asthma, atherosclerosis, osteoporosis and some cancers.

Gene Wiki entry for ALOX12 Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ALOX12 Gene

Genomics for ALOX12 Gene

Regulatory Elements for ALOX12 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ALOX12 Gene

Start:
6,996,065 bp from pter
End:
7,010,736 bp from pter
Size:
14,672 bases
Orientation:
Plus strand

Genomic View for ALOX12 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ALOX12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ALOX12 Gene

Proteins for ALOX12 Gene

  • Protein details for ALOX12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P18054-LOX12_HUMAN
    Recommended name:
    Arachidonate 12-lipoxygenase, 12S-type
    Protein Accession:
    P18054
    Secondary Accessions:
    • O95569
    • Q6ISF8
    • Q9UQM4

    Protein attributes for ALOX12 Gene

    Size:
    663 amino acids
    Molecular mass:
    75694 Da
    Cofactor:
    Name=Fe cation; Xref=ChEBI:CHEBI:24875; Note=Binds 1 Fe cation per subunit.;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ALOX12 Gene

neXtProt entry for ALOX12 Gene

Proteomics data for ALOX12 Gene at MOPED

Selected DME Specific Peptides for ALOX12 Gene

Post-translational modifications for ALOX12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ALOX12 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

Domains for ALOX12 Gene

Gene Families for ALOX12 Gene

HGNC:
  • ALOX :Arachidonate lipoxygenases
IUPHAR :

Suggested Antigen Peptide Sequences for ALOX12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P18054

UniProtKB/Swiss-Prot:

LOX12_HUMAN :
  • P18054
Domain:
  • Contains 1 lipoxygenase domain.
  • Contains 1 PLAT domain.
Family:
  • Belongs to the lipoxygenase family.
genes like me logo Genes that share domains with ALOX12: view

Function for ALOX12 Gene

Molecular function for ALOX12 Gene

GENATLAS Biochemistry: arachidonate-12-lipoxygenase,75kDa,lipid peroxidating enzyme implicated in the pathogenesis of inflammatory disorders as well as membrane remodeling,carcinogenesis,and atheroma formation,expressed in platelets erythroleukemia cells and umbilical vein endothelial cells,also in B cells and adult skin
UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=8 uM for arachidonate (PubMed:1851637, at pH 7.0 and 37 degrees Celsius) {ECO:0000269 PubMed:1851637, ECO:0000269 PubMed:8250832, ECO:0000269 PubMed:8319693}; KM=10 uM for arachidonate (PubMed:8319693, at pH 8.0 and 25 degrees Celsius) {ECO:0000269 PubMed:1851637, ECO:0000269 PubMed:8250832, ECO:0000269 PubMed:8319693}; KM=6.2 uM for arachidonate (PubMed:8250832, at pH 7.4) {ECO:0000269 PubMed:1851637, ECO:0000269 PubMed:8250832, ECO:0000269 PubMed:8319693}; KM=9 uM for linoleate (PubMed:8319693, at pH 8.0 and 25 degrees Celsius) {ECO:0000269 PubMed:1851637, ECO:0000269 PubMed:8250832, ECO:0000269 PubMed:8319693}; KM=7.9 uM for leukotriene A4 (PubMed:8250832, at pH 7.4) {ECO:0000269 PubMed:1851637, ECO:0000269 PubMed:8250832, ECO:0000269 PubMed:8319693}; KM=3 uM for eicosa-5,8,11,14,17-pentaenoate (PubMed:1851637, at pH 7.0 and 37 degrees Celsius) {ECO:0000269 PubMed:1851637, ECO:0000269 PubMed:8250832, ECO:0000269 PubMed:8319693}; KM=35 uM for eicosa-8,11,14-trienoate (PubMed:1851637, at pH 7.0 and 37 degrees Celsius) {ECO:0000269 PubMed:1851637, ECO:0000269 PubMed:8250832, ECO:0000269 PubMed:8319693}; KM=14.3 uM for 5,6-epoxy-8,11,14-eicosatrienoate (PubMed:8250832, at pH 7.4) {ECO:0000269 PubMed:1851637, ECO:0000269 PubMed:8250832, ECO:0000269 PubMed:8319693}; Vmax=3 umol/min/mg enzyme with arachidonate as substrate (PubMed:8319693, at pH 8.0 and 25 degrees Celsius) {ECO:0000269 PubMed:1851637, ECO:0000269 PubMed:8250832, ECO:0000269 PubMed:8319693}; Vmax=1.057 umol/min/mg enzyme with arachidonate as substrate (PubMed:8250832, at pH 7.4) {ECO:0000269 PubMed:1851637, ECO:0000269 PubMed:8250832, ECO:0000269 PubMed:8319693}; Vmax=0.0375 umol/min/mg enzyme with linoleate as substrate (PubMed:8319693, at pH 8.0 and 25 degrees Celsius) {ECO:0000269 PubMed:1851637, ECO:0000269 PubMed:8250832, ECO:0000269 PubMed:8319693}; Vmax=0.025 umol/min/mg enzyme with leukotriene A4 as substrate (PubMed:8250832, at pH 7.4) {ECO:0000269 PubMed:1851637, ECO:0000269 PubMed:8250832, ECO:0000269 PubMed:8319693}; Vmax=0.985 umol/min/mg enzyme with 5,6-epoxy-8,11,14- eicosatrienoate as substrate (PubMed:8250832, at pH 7.4) {ECO:0000269 PubMed:1851637, ECO:0000269 PubMed:8250832, ECO:0000269 PubMed:8319693}; pH dependence: Optimum pH is 7.5-8.0 (for arachidonate 12-lipoxygenase activity). {ECO:0000269 PubMed:8250832, ECO:0000269 PubMed:8319693};
UniProtKB/Swiss-Prot CatalyticActivity: Arachidonate + O(2) = (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate
UniProtKB/Swiss-Prot CatalyticActivity: (7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H(2)O = (5S,6R,15S)-trihydroxy-(7E,9E,11Z,13E)-eicosatetraenoate
UniProtKB/Swiss-Prot CatalyticActivity: (7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H(2)O = (5S,14R,15S)-trihydroxy-(6E,8Z,10E,12E)-eicosatetraenoate
UniProtKB/Swiss-Prot EnzymeRegulation: Activated by EGF.
UniProtKB/Swiss-Prot Function: Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Mainly converts arachidonic acid to (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE but can also metabolize linoleic acid. Has a dual activity since it also converts leukotriene A4/LTA4 into both the bioactive lipoxin A4/LXA4 and lipoxin B4/LXB4. Through the production of specific bioactive lipids like (12S)-HPETE it regulates different biological processes including platelet activation. It also probably positively regulates angiogenesis through regulation of the expression of the vascular endothelial growth factor. Plays a role in apoptotic process, promoting the survival of vascular smooth muscle cells for instance. May also play a role in the control of cell migration and proliferation.
UniProtKB/Swiss-Prot Induction: Down-regulated upon starvation, by UV-irradiation and 15-lipoxygenase metabolites.

Enzyme Numbers (IUBMB) for ALOX12 Gene

Gene Ontology (GO) - Molecular Function for ALOX12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004052 arachidonate 12-lipoxygenase activity TAS --
GO:0005506 iron ion binding IEA --
GO:0005515 protein binding IPI 10727209
GO:0016165 linoleate 13S-lipoxygenase activity IDA 8319693
GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen TAS --
genes like me logo Genes that share ontologies with ALOX12: view
genes like me logo Genes that share phenotypes with ALOX12: view

Animal Models for ALOX12 Gene

MGI Knock Outs for ALOX12:

Animal Model Products

CRISPR Products

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for ALOX12 Gene

Localization for ALOX12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ALOX12 Gene

Cytoplasm, cytosol. Membrane. Note=Membrane association is stimulated by EGF.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ALOX12 Gene COMPARTMENTS Subcellular localization image for ALOX12 gene
Compartment Confidence
cytosol 5
plasma membrane 5
mitochondrion 3
nucleus 3
extracellular 1

Gene Ontology (GO) - Cellular Components for ALOX12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 8319693
GO:0005829 cytosol TAS --
GO:0016020 membrane IDA 8912711
GO:0042383 sarcolemma IDA 15107407
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with ALOX12: view

Pathways for ALOX12 Gene

genes like me logo Genes that share pathways with ALOX12: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot P18054-LOX12_HUMAN

  • Pathway: Lipid metabolism; hydroperoxy eicosatetraenoic acid biosynthesis.

Gene Ontology (GO) - Biological Process for ALOX12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006928 movement of cell or subcellular component IMP 14669797
GO:0007568 aging IEA --
GO:0008284 positive regulation of cell proliferation ISS --
GO:0010595 positive regulation of endothelial cell migration IEA --
GO:0010628 positive regulation of gene expression IEA --
genes like me logo Genes that share ontologies with ALOX12: view

Compounds for ALOX12 Gene

(5) Tocris Compounds for ALOX12 Gene

Compound Action Cas Number
2-TEDC 5-, 12-, 15-Lipoxygenase inhibitor [132465-10-2]
BW-B 70C 5-Lipoxygenase inhibitor [134470-38-5]
MK 886 Inhibitor of 5-lipoxygenase-activating protein (FLAP) [118414-82-7]
PD 146176 Selective 15-lipoxygenase inhibitor [4079-26-9]
Zileuton Orally active 5-LOX inhibitor [111406-87-2]

(4) HMDB Compounds for ALOX12 Gene

Compound Synonyms Cas Number PubMed IDs
12(S)-HPETE
  • (5Z,8z,10e,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate
71774-10-2
Arachidonic acid
  • 5,8,11,14-Eicosatetraenoic acid
506-32-1
Iron
  • Armco iron
7439-89-6
Oxygen
  • Oxygen
7782-44-7

(81) Novoseek inferred chemical compound relationships for ALOX12 Gene

Compound -log(P) Hits PubMed IDs
12-hydroxyeicosatetraenoic acid 96.3 68
12-hpete 94.6 17
bhpp 91.3 8
arachidonic acid 91 131
n-benzyl-n-hydroxy-5-phenylpentamide 90.6 3
genes like me logo Genes that share compounds with ALOX12: view

Transcripts for ALOX12 Gene

mRNA/cDNA for ALOX12 Gene

(7) Additional mRNA sequences :
(16) Selected AceView cDNA sequences:
(2) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ALOX12 Gene

Arachidonate 12-lipoxygenase:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ALOX12

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ALOX12

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ALOX12 Gene

No ASD Table

Relevant External Links for ALOX12 Gene

GeneLoc Exon Structure for
ALOX12
ECgene alternative splicing isoforms for
ALOX12

Expression for ALOX12 Gene

mRNA expression in normal human tissues for ALOX12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ALOX12 Gene

This gene is overexpressed in Vagina (20.5), Esophagus - Mucosa (9.5), and Cervix - Ectocervix (7.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ALOX12 Gene

SOURCE GeneReport for Unigene cluster for ALOX12 Gene Hs.654431

mRNA Expression by UniProt/SwissProt for ALOX12 Gene

P18054-LOX12_HUMAN
Tissue specificity: Expressed in vascular smooth muscle cells.
genes like me logo Genes that share expressions with ALOX12: view

In Situ Assay Products

Orthologs for ALOX12 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ALOX12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ALOX12 35
  • 99.24 (n)
  • 99.02 (a)
ALOX12 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ALOX12 35
  • 88.89 (n)
  • 87.33 (a)
ALOX12 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ALOX12 35
  • 87.53 (n)
  • 85.97 (a)
ALOX12 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Alox12 35
  • 85.42 (n)
  • 85.52 (a)
Alox12 16
Alox12 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 64 (a)
OneToMany
-- 36
  • 58 (a)
OneToMany
-- 36
  • 67 (a)
OneToMany
-- 36
  • 32 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 87 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Alox12 35
  • 84.97 (n)
  • 84.31 (a)
zebrafish
(Danio rerio)
Actinopterygii alox12 35
  • 53.39 (n)
  • 46.05 (a)
alox12 36
  • 46 (a)
OneToMany
wufb72a11 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 29 (a)
ManyToMany
-- 36
  • 32 (a)
ManyToMany
-- 36
  • 28 (a)
ManyToMany
CSA.6148 36
  • 29 (a)
ManyToMany
Species with no ortholog for ALOX12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ALOX12 Gene

ENSEMBL:
Gene Tree for ALOX12 (if available)
TreeFam:
Gene Tree for ALOX12 (if available)

Paralogs for ALOX12 Gene

Paralogs for ALOX12 Gene

Selected SIMAP similar genes for ALOX12 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for ALOX12 Gene

genes like me logo Genes that share paralogs with ALOX12: view

Variants for ALOX12 Gene

Sequence variations from dbSNP and Humsavar for ALOX12 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
VAR_004279 -
VAR_018743 -
VAR_018744 -
VAR_018745 -
VAR_030471 -

Structural Variations from Database of Genomic Variants (DGV) for ALOX12 Gene

Variant ID Type Subtype PubMed ID
esv2422288 CNV Deletion 17116639
nsv907633 CNV Loss 21882294
nsv907634 CNV Loss 21882294
esv1008363 CNV Loss 20482838
nsv457659 CNV Loss 19166990

Relevant External Links for ALOX12 Gene

HapMap Linkage Disequilibrium report
ALOX12
Human Gene Mutation Database (HGMD)
ALOX12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ALOX12 Gene

Disorders for ALOX12 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (6) Diseases for ALOX12 Gene including...

Search for ALOX12 Gene in MalaCards »

UniProtKB/Swiss-Prot

LOX12_HUMAN
  • Esophageal cancer (ESCR) [MIM:133239]: A malignancy of the esophagus. The most common types are esophageal squamous cell carcinoma and adenocarcinoma. Cancer of the esophagus remains a devastating disease because it is usually not detected until it has progressed to an advanced incurable stage. {ECO:0000269 PubMed:17460548}. Note=Disease susceptibility may be associated with variations affecting the gene represented in this entry. Gln at position 261 may confer interindividual susceptibility to esophageal cancer (PubMed:17460548). {ECO:0000269 PubMed:17460548}.
  • Colorectal cancer (CRC) [MIM:114500]: A complex disease characterized by malignant lesions arising from the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history. {ECO:0000269 PubMed:17151091}. Note=Disease susceptibility may be associated with variations affecting the gene represented in this entry. Gln at position 261 may confer interindividual susceptibility to colorectal cancer (PubMed:17460548). {ECO:0000269 PubMed:17460548}.

(41) Novoseek inferred disease relationships for ALOX12 Gene

Disease -log(P) Hits PubMed IDs
erythroleukemia 60.9 10
carcinoma squamous cell 42.2 17
prostate cancer 35.7 41
prostate carcinoma 34.7 7
atherosclerosis 32 6

Relevant External Links for ALOX12

Genetic Association Database (GAD)
ALOX12
Human Genome Epidemiology (HuGE) Navigator
ALOX12
genes like me logo Genes that share disorders with ALOX12: view

Publications for ALOX12 Gene

  1. Associations of functional polymorphisms in cyclooxygenase-2 and platelet 12-lipoxygenase with risk of occurrence and advanced disease status of colorectal cancer. (PMID: 17151091) Tan W. … Lin D. (Carcinogenesis 2007) 3 4 23 48
  2. Platelet 12-lipoxygenase Arg261Gln polymorphism: functional characterization and association with risk of esophageal squamous cell carcinoma in combination with COX-2 polymorphisms. (PMID: 17460548) Guo Y. … Lin D. (Pharmacogenet. Genomics 2007) 3 4 23 48
  3. Polymorphisms in ALOX12, but not ALOX15, are significantly associated with BMD in postmenopausal women. (PMID: 17520163) Mullin B.H. … Wilson S.G. (Calcif. Tissue Int. 2007) 3 23 48
  4. Mechanisms regulating tumor angiogenesis by 12-lipoxygenase in prostate cancer cells. (PMID: 16638750) Nie D. … Honn K.V. (J. Biol. Chem. 2006) 3 4 23
  5. Common polymorphisms in 5-lipoxygenase and 12-lipoxygenase genes and the risk of incident, sporadic colorectal adenoma. (PMID: 17236225) Gong Z. … Xie D. (Cancer 2007) 3 23 48

Products for ALOX12 Gene

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