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ALOX12 Gene

protein-coding   GIFtS: 66
GCID: GC17P006899

Arachidonate 12-Lipoxygenase

  See ALOX12-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Arachidonate 12-Lipoxygenase1 2     12-LOX2
Platelet 12-LOX1 2     Arachidonate 12-Lipoxygenase, 12S-Type2
Lipoxin Synthase 12-LO2 3     Platelet-Type 12-Lipoxygenase2
Platelet-Type Lipoxygenase 122 3     12LO3
12S-LOX2 3     EC 1.13.11.313
12S-lipoxygenase2 3     EC 3.3.2.-3
LOG122 3     EC 1.13.118
12(S)-lipoxygenase2     

External Ids:    HGNC: 4291   Entrez Gene: 2392   Ensembl: ENSG000001088397   OMIM: 1523915   UniProtKB: P180543   

Export aliases for ALOX12 gene to outside databases

Previous GC identifers: GC17P007287 GC17P007630 GC17P006741 GC17P007099 GC17P006840


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ALOX12 Gene:
ALOX12 (arachidonate 12-lipoxygenase) is a protein-coding gene. Diseases associated with ALOX12 include essential thrombocythemia, and osteoporosis. GO annotations related to this gene include arachidonate 12-lipoxygenase activity and iron ion binding. An important paralog of this gene is ALOX12B.

UniProtKB/Swiss-Prot: LOX12_HUMAN, P18054
Function: Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and
esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Mainly converts
arachidonic acid to (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE but can also metabolize linoleic acid. Has
a dual activity since it also converts leukotriene A4/LTA4 into both the bioactive lipoxin A4/LXA4 and lipoxin
B4/LXB4. Through the production of specific bioactive lipids like (12S)-HPETE it regulates different biological
processes including platelet activation. It also probably positively regulates angiogenesis through regulation of
the expression of the vascular endothelial growth factor. Plays a role in apoptotic process, promoting the
survival of vascular smooth muscle cells for instance. May also play a role in the control of cell migration and
proliferation

summary for ALOX12 Gene:
Lipoxygenases (LOXs) are a family of non-heme iron dioxygenases that are involved in the production and
metabolism of fatty acid hydroperoxidases. There are six lipoxygenase isozymes; 5-LOX, 12R-LOX, 12S-LOX,
15-LOX-1 and 15-LOX-2, which catalyze the regio-selective addition of oxygen into arachidonic acid, and
epidermal LOX (E-LOX) which metabolizes 12R-hydroperoxyeicosatetraenoic acid (12R-HPETE) to a specific
epoxyalcohol compound. Different isozymes have different physiological roles; 5-, 12R-, 12S- and 15-LOX-1
have proliferative, antiapoptotic and angiogenic functions whilst 15-LOX-2 has roles in differentiation,
growth arrest and the induction of apoptosis. E-LOX, the most divergent member of this family, is involved
in terminal differentiation of keratinocytes and has a major role in skin barrier function. Perturbations in
lipoxygenase enzymes have been implicated in various human diseases including bronchial asthma,
atherosclerosis, osteoporosis and some cancers.

Gene Wiki entry for ALOX12 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010718.17  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ALOX12 gene promoter:
         AML1a   Lmo2   Nkx2-5   YY1   FOXL1   Zic1   ZIC2/Zic2   LyF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidALOX12 promoter sequence
   Search Chromatin IP Primers for ALOX12

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ALOX12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.1   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p13.1

ALOX12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ALOX12 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P006899:  view genomic region     (about GC identifiers)

Start:
6,899,384 bp from pter      End:
6,914,055 bp from pter
Size:
14,672 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: LOX12_HUMAN, P18054 (See protein sequence)
Recommended Name: Arachidonate 12-lipoxygenase, 12S-type  
Size: 663 amino acids; 75694 Da
Cofactor: Binds 1 iron ion per subunit
2 PDB 3D structures from and Proteopedia for ALOX12:
2ABU (3D)        3D3L (3D)    
Secondary accessions: O95569 Q6ISF8 Q9UQM4

Explore the universe of human proteins at neXtProt for ALOX12: NX_P18054

Explore proteomics data for ALOX12 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 3 DME Specific Peptides for ALOX12 (P18054)
     CPPDDLA  WVPNAPCTMR  GMEELQAQLEKEL 


    See ALOX12 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000688.2  
    ENSEMBL proteins: 
     ENSP00000251535   ENSP00000467033  
    Reactome Protein details: P18054

    ALOX12 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for ALOX12

     
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    antibodies-online proteins for ALOX12 (7 products) 

     
    antibodies-online peptides for ALOX12

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    antibodies-online antibodies for ALOX12 (11 products) 

    ALOX12 Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ALOX: Arachidonate lipoxygenases

    IUPHAR Guide to PHARMACOLOGY protein family classification: 12S-LOX
    Lipoxygenases

    Selected InterPro protein domains (see all 7):
     IPR020833 LipOase_Fe_BS
     IPR013819 LipOase_C
     IPR001024 PLAT/LH2_dom
     IPR008976 Lipase_LipOase
     IPR020834 LipOase_CS

    Graphical View of Domain Structure for InterPro Entry P18054

    ProtoNet protein and cluster: P18054

    3 Blocks protein domains:
    IPB000907 Lipoxygenase
    IPB001024 Lipoxygenase
    IPB001885 Mammalian lipoxygenase signature


    UniProtKB/Swiss-Prot: LOX12_HUMAN, P18054
    Similarity: Belongs to the lipoxygenase family
    Similarity: Contains 1 lipoxygenase domain
    Similarity: Contains 1 PLAT domain


    Find genes that share domains with ALOX12           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LOX12_HUMAN, P18054
    Function: Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and
    esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Mainly converts
    arachidonic acid to (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE but can also metabolize linoleic acid. Has
    a dual activity since it also converts leukotriene A4/LTA4 into both the bioactive lipoxin A4/LXA4 and lipoxin
    B4/LXB4. Through the production of specific bioactive lipids like (12S)-HPETE it regulates different biological
    processes including platelet activation. It also probably positively regulates angiogenesis through regulation of
    the expression of the vascular endothelial growth factor. Plays a role in apoptotic process, promoting the
    survival of vascular smooth muscle cells for instance. May also play a role in the control of cell migration and
    proliferation
    Catalytic activity: Arachidonate + O(2) = (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate
    Catalytic activity: (7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H(2)O =
    (5S,6R,15S)-trihydroxy-(7E,9E,11Z,13E)-eicosatetraenoate
    Catalytic activity: (7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H(2)O =
    (5S,14R,15S)-trihydroxy-(6E,8Z,10E,12E)-eicosatetraenoate
    Enzyme regulation: Activated by EGF
    Biophysicochemical properties: Kinetic parameters: KM=8 uM for arachidonate (PubMed:1851637, at pH 7.0 and 37
    degrees Celsius); KM=10 uM for arachidonate (PubMed:8319693, at pH 8.0 and 25 degrees Celsius); KM=6.2 uM for
    arachidonate (PubMed:8250832, at pH 7.4); KM=9 uM for linoleate (PubMed:8319693, at pH 8.0 and 25 degrees
    Celsius); KM=7.9 uM for leukotriene A4 (PubMed:8250832, at pH 7.4); KM=3 uM for eicosa-5,8,11,14,17-pentaenoate
    (PubMed:1851637, at pH 7.0 and 37 degrees Celsius); KM=35 uM for eicosa-8,11,14-trienoate (PubMed:1851637, at pH
    7.0 and 37 degrees Celsius); KM=14.3 uM for 5,6-epoxy-8,11,14-eicosatrienoate (PubMed:8250832, at pH 7.4); Vmax=3
    umol/min/mg enzyme with arachidonate as substrate (PubMed:8319693, at pH 8.0 and 25 degrees Celsius); Vmax=1.057
    umol/min/mg enzyme with arachidonate as substrate (PubMed:8250832, at pH 7.4); Vmax=0.0375 umol/min/mg enzyme
    with linoleate as substrate (PubMed:8319693, at pH 8.0 and 25 degrees Celsius); Vmax=0.025 umol/min/mg enzyme
    with leukotriene A4 as substrate (PubMed:8250832, at pH 7.4); Vmax=0.985 umol/min/mg enzyme with
    5,6-epoxy-8,11,14- eicosatrienoate as substrate (PubMed:8250832, at pH 7.4); pH dependence: Optimum pH is 7.5-8.0
    (for arachidonate 12-lipoxygenase activity);
    Induction: Down-regulated upon starvation, by UV-irradiation and 15-lipoxygenase metabolites

         Genatlas biochemistry entry for ALOX12:
    arachidonate-12-lipoxygenase,75kDa,lipid peroxidating enzyme implicated in the pathogenesis of inflammatory
    disorders as well as membrane remodeling,carcinogenesis,and atheroma formation,expressed in platelets
    erythroleukemia cells and umbilical vein endothelial cells,also in B cells and adult skin

         Enzyme Numbers (IUBMB): EC 3.3.2.-1 EC 1.13.11.311 EC 1.13.112

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004052arachidonate 12-lipoxygenase activity TAS--
    GO:0005506iron ion binding IEA--
    GO:0005515protein binding IPI10727209
    GO:0016165linoleate 13S-lipoxygenase activity IDA8319693
    GO:0016702oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen TAS--
         
    Find genes that share ontologies with ALOX12           About GenesLikeMe


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Alox12):
     hematopoietic system  homeostasis/metabolism  immune system  integument 

    Find genes that share phenotypes with ALOX12           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Alox12tm1Fun for ALOX12

       genOway: Develop your customized and physiologically relevant rodent model for ALOX12

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat ALOX12 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ALOX12 (see all 9):
    hsa-miR-374b* hsa-miR-424 hsa-miR-922 hsa-miR-15a hsa-miR-497 hsa-miR-195 hsa-miR-16 hsa-miR-15b
    SwitchGear 3'UTR luciferase reporter plasmidALOX12 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat ALOX12

    Gene Editing
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    Browse Sino Biological Human cDNA Clones
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    LOX12_HUMAN, P18054: Cytoplasm, cytosol. Membrane. Note=Membrane association is stimulated by EGF
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    plasma membrane5
    mitochondrion3
    nucleus3
    extracellular1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA8319693
    GO:0005829cytosol TAS--
    GO:0016020membrane IDA8912711
    GO:0042383sarcolemma IDA15107407
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with ALOX12           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ALOX12 About    
    See pathways by source

    SuperPathContained pathways About
    1Arachidonic acid metabolism
    Arachidonic acid metabolism0.41
    Synthesis of 12-eicosatetraenoic acid derivatives0.00
    Arachidonic acid metabolism0.40
    lipoxin biosynthesis0.00
    HETE and HPETE biosynthesis and metabolism0.33
    Synthesis of Lipoxins (LX)0.00
    Synthesis of Hepoxilins (HX) and Trioxilins (TrX)0.00
    2Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    Metabolic pathways0.38
    3Development Endothelin 1 EDNRA signaling
    Inflammatory mediator regulation of TRP channels0.37
    4Circadian entrainment
    Serotonergic synapse0.33
    5Eicosanoid Synthesis
    Eicosanoid Synthesis


    Find genes that share SuperPaths with ALOX12           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for ALOX12
        HETE and HPETE biosynthesis and metabolism

    2 BioSystems Pathways for ALOX12
        Eicosanoid Synthesis
    lipoxin biosynthesis

    3 Reactome Pathways for ALOX12
        Synthesis of Lipoxins (LX)
    Synthesis of Hepoxilins (HX) and Trioxilins (TrX)
    Synthesis of 12-eicosatetraenoic acid derivatives


    4 Kegg Pathways  (Kegg details for ALOX12):
        Arachidonic acid metabolism
    Metabolic pathways
    Serotonergic synapse
    Inflammatory mediator regulation of TRP channels

    UniProtKB/Swiss-Prot: LOX12_HUMAN, P18054
    Pathway: Lipid metabolism; hydroperoxy eicosatetraenoic acid biosynthesis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ALOX12: 

              Oxidative Stress in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              Apoptosis 384HT in human mouse rat
              Drug Metabolism in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ALOX12

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ALOX12 (P180541, 2, 3 ENSP000002515354) via UniProtKB, MINT, STRING, and/or I2D (see all 47)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LMNAP025451, 3, ENSP000003572834EBI-1633210,EBI-351935 I2D: score=4 STRING: ENSP00000357283
    PLA2G2AP145552, 3, ENSP000003642524MINT-50574 I2D: score=2 STRING: ENSP00000364252
    KRT5P136471, 3, ENSP000002522424EBI-1633210,EBI-702187 I2D: score=6 STRING: ENSP00000252242
    ITGB4P161443, ENSP000002001814I2D: score=4 STRING: ENSP00000200181
    KRT85P783863, ENSP000002579014I2D: score=1 STRING: ENSP00000257901
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 35):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006928cellular component movement IMP14669797
    GO:0007568aging IEA--
    GO:0008284positive regulation of cell proliferation ISS--
    GO:0010595positive regulation of endothelial cell migration IEA--
    GO:0010628positive regulation of gene expression IEA--

    Find genes that share ontologies with ALOX12           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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      Browse compounds at ApexBio 

    Compounds for ALOX12 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    BAY-X 1005Orally active 5-lipoxygenase activating protein (FLAP) inhibitor[128253-31-6]
    BW-B 70C5-Lipoxygenase inhibitor[134470-38-5]
    ZileutonOrally active 5-LOX inhibitor[111406-87-2]
    MK 886Inhibitor of 5-lipoxygenase-activating protein (FLAP)[118414-82-7]
    Baicalein5- and 12-Lipoxygenase inhibitor[491-67-8]

    4 HMDB Compounds for ALOX12    About this table
    CompoundSynonyms CAS #PubMed Ids
    12(S)-HPETE(5Z,8z,10e,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate (see all 7)71774-10-2--
    Arachidonic acid5,8,11,14-Eicosatetraenoic acid (see all 16)506-32-1--
    IronArmco iron (see all 19)7439-89-6--
    OxygenOxygen (see all 5)7782-44-7--

    Selected Novoseek inferred chemical compound relationships for ALOX12 gene (see all 81)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    12-hydroxyeicosatetraenoic acid 96.3 125 10588925 (4), 16514435 (3), 14518561 (3), 17522976 (2) (see all 53)
    12-hpete 94.6 21 10830714 (1), 12848295 (1), 16828271 (1), 15474031 (1) (see all 17)
    bhpp 91.3 11 10733500 (2), 7593207 (1), 7540838 (1), 9174106 (1) (see all 7)
    arachidonic acid 91 216 8829479 (4), 11115402 (4), 19235890 (3), 14518561 (3) (see all 99)
    n-benzyl-n-hydroxy-5-phenylpentamide 90.6 4 12874035 (1), 10861450 (1), 11980674 (1)
    baicalein 90 55 19439216 (4), 17050058 (4), 17263456 (2), 12874035 (1) (see all 29)
    hepoxilin b3 89.4 5 10692117 (3), 2180942 (1), 11851887 (1)
    hepoxilin a3 87 4 2106877 (2), 12432937 (1)
    12(s)-hydroperoxyeicosatetraenoic acid 84.8 3 8188678 (1), 10588925 (1), 16638750 (1)
    13-hydroperoxyoctadecadienoic acid 81.7 2 12218361 (1), 10882192 (1)



    Find genes that share compounds with ALOX12           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ALOX12 gene: 
    NM_000697.2  

    Unigene Cluster for ALOX12:

    Arachidonate 12-lipoxygenase
    Hs.654431  [show with all ESTs]
    Unigene Representative Sequence: NM_000697
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000251535(uc002gdx.4) ENST00000480801 ENST00000406228(uc002gdz.4)

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    Additional mRNA sequence: 

    AF143883.1 BC069557.1 M35418.1 M58704.1 M62982.1 S68587.1 S68588.1 

    3 DOTS entries:

    DT.209219  DT.100019329  DT.91754446 

    16 AceView cDNA sequences:

    AF143883 NM_000697 S68587 M62982 M58704 M35418 BC069557 BG900221 
    AW374333 BI044580 BV184224 T63474 BF773448 T97387 T63549 T97276 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ALOX12 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAATGAGTG
    ALOX12 Expression
    About this image


    ALOX12 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Myoblasts Mandibular Arch Muscles
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    ALOX12 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ALOX12 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.654431

    UniProtKB/Swiss-Prot: LOX12_HUMAN, P18054
    Tissue specificity: Expressed in vascular smooth muscle cells

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ALOX12: 
              Oxidative Stress in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat
              Apoptosis 384HT in human mouse rat
              Drug Metabolism in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ALOX12 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Alox121 , 5 arachidonate 12-lipoxygenase1, 5 85.42(n)1
    85.52(a)1
      11 (42.99 cM)5
    116841  NM_007440.41  NP_031466.21 
     702414575 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb72a112 wufb72a11 73.62(n)   322732  BC054621.1 


    ENSEMBL Gene Tree for ALOX12 (if available)
    TreeFam Gene Tree for ALOX12 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ALOX12 gene
    ALOX12B2  ALOX52  ALOX15B2  ALOXE32  ALOX152  
    6 SIMAP similar genes for ALOX12 using alignment to 2 protein entries:     LOX12_HUMAN (see all proteins):
    arachidonate 12-lipoxygenase    ALOX15    ALOX5    ALOX12B    ALOX15B    ALOXE3

    Find genes that share paralogs with ALOX12           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for ALOX12
    PGOHUM00000237213 PGOHUM00000237343 PGOHUM00000262364


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    6 SNPs for ALOX12    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs49871041,2,4
    ----see VAR_0304712 mis40--------
    rs11266671,2,4
    ----see VAR_0187432 mis40--------
    rs115713421,2,4
    ----see VAR_0187452 mis40--------
    VAR_0042794
    ----see VAR_0042792 A T mis40--------
    rs4344731,2,4
    ----see VAR_0187442 mis40--------
    rs3727223241,2
    ----6791262(+) TAAAA-/TGGTTTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ALOX12 (6899384 - 6914055 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for ALOX12:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2422288CNV Deletion17116639
    esv1008363CNV Loss20482838
    nsv457659CNV Loss19166990
    nsv907633CNV Loss21882294
    nsv907634CNV Loss21882294

    Human Gene Mutation Database (HGMD): ALOX12
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ALOX12
    DNA2.0 Custom Variant and Variant Library Synthesis for ALOX12

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 152391    OMIM disorders: --

    UniProtKB/Swiss-Prot: LOX12_HUMAN, P18054
  • Esophageal cancer (ESCR) [MIM:133239]: A malignancy of the esophagus. The most common types are
    esophageal squamous cell carcinoma and adenocarcinoma. Cancer of the esophagus remains a devastating disease
    because it is usually not detected until it has progressed to an advanced incurable stage. Note=Disease
    susceptibility may be associated with variations affecting the gene represented in this entry. Gln at position
    261 may confer interindividual susceptibility to esophageal cancer (PubMed:17460548)
  • Colorectal cancer (CRC) [MIM:114500]: A complex disease characterized by malignant lesions arising from
    the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with
    progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon
    and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history. Note=Disease
    susceptibility may be associated with variations affecting the gene represented in this entry. Gln at position
    261 may confer interindividual susceptibility to colorectal cancer (PubMed:17460548)

  • 7 diseases for ALOX12:    
    About MalaCards
    essential thrombocythemia    osteoporosis    atherosclerosis    asthma
    essential hypertension    pancreatic cancer    prostate cancer


    Find genes that share disorders with ALOX12           About GenesLikeMe

    Selected Novoseek inferred disease relationships for ALOX12 gene (see all 41)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    erythroleukemia 60.9 10 10830714 (2), 2244907 (2), 8443239 (2), 8295977 (1) (see all 7)
    carcinoma squamous cell 42.2 20 10428482 (2), 9174106 (2), 9443600 (2), 7525931 (1) (see all 14)
    prostate cancer 35.7 61 7624992 (5), 11980674 (5), 10818452 (4), 9321930 (4) (see all 16)
    prostate carcinoma 34.7 7 14669797 (3), 10667391 (1), 17443494 (1), 10861450 (1) (see all 5)
    atherosclerosis 32 6 17459368 (1), 18296557 (1), 10504415 (1), 11845232 (1) (see all 6)
    cancer 29.8 25 12874035 (3), 7825842 (1), 15034803 (1), 16731771 (1) (see all 17)
    tumors 27 78 10861450 (4), 14669797 (4), 10818452 (3), 12085962 (3) (see all 36)
    skin tumor 24.4 3 15305153 (2), 10667390 (1)
    metastasis 22.6 31 14669797 (3), 7712597 (2), 20303950 (2), 12394183 (2) (see all 16)
    psoriasis 22.5 9 17521953 (2), 8304420 (1), 16019177 (1), 18755188 (1) (see all 5)

    Genetic Association Database (GAD): ALOX12
    Human Genome Epidemiology (HuGE) Navigator: ALOX12 (36 documents)

    Export disorders for ALOX12 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ALOX12 gene, integrated from 10 sources (see all 407):
    (articles sorted by number of sources associating them with ALOX12)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Platelet 12-lipoxygenase Arg261Gln polymorphism: functional characterization and association with risk of esophageal squamous cell carcinoma in combination with COX-2 polymorphisms. (PubMed id 17460548)1, 2, 4, 9 Guo Y....Lin D. (Pharmacogenet. Genomics 2007)
    2. Associations of functional polymorphisms in cyclooxygenase-2 and platelet 12-lipoxygenase with risk of occurrence and advanced disease status of colorectal cancer. (PubMed id 17151091)1, 2, 4, 9 Tan W....Lin D. (Carcinogenesis 2007)
    3. Arachidonate lipoxygenase (ALOX) and cyclooxygenase (COX) polymorphisms and colon cancer risk. (PubMed id 15308583)1, 2, 4 Goodman J.E.... Harris C.C. (Carcinogenesis 2004)
    4. Characterization of human 12-lipoxygenase genes. (PubMed id 1570320)1, 2, 3 Funk C.D.... Samuelsson B. (Proc. Natl. Acad. Sci. U.S.A. 1992)
    5. Mechanisms regulating tumor angiogenesis by 12-lipoxygenase in prostate cancer cells. (PubMed id 16638750)1, 2, 9 Nie D....Honn K.V. (J. Biol. Chem. 2006)
    6. Polymorphisms in ALOX12, but not ALOX15, are significantly associated with BMD in postmenopausal women. (PubMed id 17520163)1, 4, 9 Mullin B.H....Wilson S.G. (Calcif. Tissue Int. 2007)
    7. Human ALOX12, but not ALOX15, is associated with BMD in white men and women. (PubMed id 16598376)1, 4, 9 Ichikawa S....Econs M.J. (J. Bone Miner. Res. 2006)
    8. 12-Lipoxygenase in A431 cells: genetic identity, modulation of expression, and intracellular localization. (PubMed id 8912711)1, 2, 9 Hagmann W....Honn K.V. (Exp. Cell Res. 1996)
    9. Platelet-type 12-lipoxygenase in a human prostate carcinoma stimulates angiogenesis and tumor growth. (PubMed id 9751607)1, 2, 9 Nie D....Honn K.V. (Cancer Res. 1998)
    10. Purification and characterization of recombinant histidine-tagged human platelet 12-lipoxygenase expressed in a baculovirus/insect cell system. (PubMed id 8319693)1, 2, 9 Chen X.S....Funk C.D. (Eur. J. Biochem. 1993)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 239 HGNC: 429 AceView: ALOX12 Ensembl:ENSG00000108839 euGenes: HUgn239
    ECgene: ALOX12 Kegg: 239 H-InvDB: ALOX12

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ALOX12 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ALOX12 Genetics and Cytogenetics in Oncology and Haematology
    SeattleSNPshttp://pga.gs.washington.edu/data/alox12/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ALOX12 gene:
    Search GeneIP for patents involving ALOX12

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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