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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ALOX12 Gene

protein-coding GIFtS: 65
GCID: GC17P006899

arachidonate 12-lipoxygenase

Explore 59 diseases affiliated with
ALOX12 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Arachidonate 12-Lipoxygenase¹ ²		12-LOX²
12S-LOX¹ ² ³		Arachidonate 12-Lipoxygenase, 12S-Type²
Platelet-Type Lipoxygenase 12² ³		Platelet 12-LOX²
12S-Lipoxygenase¹		Platelet-Type 12-Lipoxygenase²
LOG12² ³		EC 1.13.11.31³
12(S)-Lipoxygenase¹		EC 1.13.11⁸

External Ids:	HGNC: 429¹	Entrez Gene: 239²	Ensembl: ENSG00000108839⁷	OMIM: 152391⁵	UniProtKB: P18054³

Export aliases for ALOX12 gene to outside databases

Previous GC identifers: GC17P007287 GC17P007630 GC17P006741 GC17P007099 GC17P006840

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: LOX12_HUMAN, P18054

Function: Oxygenase and 14,15-leukotriene A4 synthase activity

summary for ALOX12:

Lipoxygenases (LOXs) are a family of non-heme iron dioxygenases that are involved in the production and

metabolism of fatty acid hydroperoxidases. There are six lipoxygenase isozymes; 5-LOX, 12R-LOX, 12S-LOX,

15-LOX-1 and 15-LOX-2, which catalyze the regio-selective addition of oxygen into arachidonic acid, and

epidermal LOX (E-LOX) which metabolizes 12R-hydroperoxyeicosatetraenoic acid (12R-HPETE) to a specific

epoxyalcohol compound. Different isozymes have different physiological roles; 5-, 12R-, 12S- and 15-LOX-1

have proliferative, antiapoptotic and angiogenic functions whilst 15-LOX-2 has roles in differentiation,

growth arrest and the induction of apoptosis. E-LOX, the most divergent member of this family, is involved

in terminal differentiation of keratinocytes and has a major role in skin barrier function. Perturbations in

lipoxygenase enzymes have been implicated in various human diseases including bronchial asthma,

atherosclerosis, osteoporosis and some cancers.

Gene Wiki entry for ALOX12

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.1 NT_010718.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ALOX12 gene promoter:
AML1a Lmo2 Nkx2-5 YY1 FOXL1 Zic1 ZIC2/Zic2 LyF-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ALOX12 promoter sequence

Search SABiosciences Chromatin IP Primers for ALOX12

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ALOX12

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.1 Ensembl cytogenetic band: 17p13.1 HGNC cytogenetic band: 17p13.1

ALOX12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ALOX12 gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P006899: view genomic region (about GC identifiers)

Start:	6,899,384 bp from pter	End:	6,914,055 bp from pter
Size:	14,672 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: LOX12_HUMAN, P18054 (See protein sequence)

Recommended Name: Arachidonate 12-lipoxygenase, 12S-type

Size: 663 amino acids; 75694 Da

Cofactor: Binds 1 iron ion per subunit

Subcellular location: Cytoplasm

2 PDB 3D structures from and Proteopedia for ALOX12:

2ABU (3D)

3D3L (3D)

Secondary accessions: O95569 Q6ISF8 Q9UQM4

Explore the universe of human proteins at neXtProt for ALOX12: NX_P18054

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P18054

3 DME Specific Peptides for ALOX12 (P18054)

CPPDDLA

WVPNAPCTMR

GMEELQAQLEKEL

ALOX12 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_000688.2

ENSEMBL proteins:

ENSP00000251535 ENSP00000467033

Reactome Protein details: P18054
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Novus Biologicals ALOX12 Proteins Novus Biologicals ALOX12 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for ALOX12

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005829	cytosol	IDA	15107407
GO:0042383	sarcolemma	IDA	15107407

ALOX12 for ontologies About GeneDecksing

ALOX12 Antibody Products:

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	ThermoFisher Antibody for ALOX12

Assay Products for ALOX12:

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	Uscn ELISAs and CLIAs for ALOX12

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ALOX12 for domains About GeneDecksing

5/7 InterPro domains/families (see all 7):

IPR020833 LipOase_Fe_BS

IPR013819 LipOase_C

IPR001024 LipOase_LH2

IPR008976 Lipase_LipOase

IPR020834 LipOase_CS

Graphical View of Domain Structure for InterPro Entry P18054

ProtoNet protein and cluster: P18054

3 Blocks protein families:

IPB000907 Lipoxygenase

IPB001024 Lipoxygenase

IPB001885 Mammalian lipoxygenase signature

UniProtKB/Swiss-Prot: LOX12_HUMAN, P18054

Similarity: Belongs to the lipoxygenase family

Similarity: Contains 1 lipoxygenase domain

Similarity: Contains 1 PLAT domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: LOX12_HUMAN, P18054

Function: Oxygenase and 14,15-leukotriene A4 synthase activity

Catalytic activity: Arachidonate + O(2) = (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate

Genatlas biochemistry entry for ALOX12:

arachidonate-12-lipoxygenase,75kDa,lipid peroxidating enzyme implicated in the pathogenesis of inflammatory disorders

as well as membrane remodeling,carcinogenesis,and atheroma formation,expressed in platelets erythroleukemia cells and

umbilical vein endothelial cells,also in B cells and adult skin

Enzyme Numbers (IUBMB): EC 1.13.11.31¹ EC 1.13.11²

miRNA Products:		OriGene 3'-UTR Clone: ALOX12 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ALOX12
		8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate ALOX12 (see all 9):
		hsa-miR-374b* hsa-miR-424 hsa-miR-922 hsa-miR-15a hsa-miR-497 hsa-miR-195 hsa-miR-16 hsa-miR-15b

		SwitchGear 3'UTR luciferase reporter plasmid: ALOX12 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ALOX12 (see all 7) OriGene shRNA RFP: ALOX12 OriGene siRNA: ALOX12
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ALOX12

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for ALOX12

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		GenScript: all cDNA clones in your preferred vector: ALOX12 (NM_000697)
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ALOX12
		Search LifeMap BioReagents cell lines for ALOX12

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALOX12

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004052	arachidonate 12-lipoxygenase activity	IDA	2217179
GO:0005506	iron ion binding	IEA	--
GO:0005515	protein binding	IPI	10727209
GO:0016165	lipoxygenase activity	IEA	--
GO:0047977	hepoxilin-epoxide hydrolase activity	ISS	--

ALOX12 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Alox12^tm1Fun for ALOX12
     4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Alox12):

hematopoietic system

homeostasis/metabolism

immune system

integument

ALOX12 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Arachidonic acid metabolism

Arachidonic acid metabolism	1.00	HETE and HPETE biosynthesis and metabolism	0.39
Arachidonic acid metabolism	0.42	Eicosanoid Synthesis	0.31
HETE and HPETE biosynthesis and metabolism	0.39

Metabolism

	Metabolism	1.00			Metabolism of lipids and lipoproteins	0.34
	Metabolic pathways	0.38

Synthesis of 15-eicosatetraenoic acid derivatives

Synthesis of 12-eicosatetraenoic acid derivatives

0.50

Synthesis of Lipoxins (LX)

0.00

Synthesis of Hepoxilins (HX) and Trioxilins (TrX)

Synthesis of Hepoxilins (HX) and Trioxilins (TrX)

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for ALOX12

HETE and HPETE biosynthesis and metabolism

1 GeneGo (Thomson Reuters) Pathway for ALOX12

HETE and HPETE biosynthesis and metabolism

1 BioSystems Pathway for ALOX12

Eicosanoid Synthesis

5/6 Reactome Pathways for ALOX12 (see all 6)

	Synthesis of Lipoxins (LX)
	Synthesis of Hepoxilins (HX) and Trioxilins (TrX)
	Metabolism
	Arachidonic acid metabolism
	Synthesis of 12-eicosatetraenoic acid derivatives

2 Kegg Pathways (Kegg details for ALOX12):

	Arachidonic acid metabolism
	Metabolic pathways

UniProtKB/Swiss-Prot: LOX12_HUMAN, P18054

Pathway: Lipid metabolism; leukotriene D4 biosynthesis

ALOX12 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for ALOX12

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/47 Interacting proteins for ALOX12 (P18054^{1, 2, 3} ENSP00000251535⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 47)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
LMNA	P02545¹^,³, ENSP00000357283⁴	EBI-1633210,EBI-351935 I2D: score=4 STRING: ENSP00000357283
PLA2G2A	P14555²^,³, ENSP00000364252⁴	MINT-50574 I2D: score=2 STRING: ENSP00000364252
KRT5	P13647¹^,³, ENSP00000252242⁴	EBI-1633210,EBI-702187 I2D: score=6 STRING: ENSP00000252242
ITGB4	P16144³, ENSP00000200181⁴	I2D: score=4 STRING: ENSP00000200181
KRT85	P78386³, ENSP00000257901⁴	I2D: score=1 STRING: ENSP00000257901

About this table

Gene Ontology (GO): 5/22 biological process terms (GO ID links to tree view) (see all 22): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006928	cellular component movement	IMP	14669797
GO:0007568	aging	IEA	--
GO:0008284	positive regulation of cell proliferation	ISS	--
GO:0010595	positive regulation of endothelial cell migration	IEA	--
GO:0010628	positive regulation of gene expression	IEA	--

ALOX12 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

ALOX12 for compounds About GeneDecksing

EMD Millipore small molecules for ALOX12:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Compounds for ALOX12 available from Tocris Bioscience About this table

Compound	Action	CAS #
2-TEDC	5-, 12-, 15-Lipoxygenase inhibitor	[132465-10-2]
Baicalein	5- and 12-Lipoxygenase inhibitor	[491-67-8]

4 HMDB Compounds for ALOX12 About this table

Compound	Synonyms	CAS #	PubMed Ids
12(S)-HPETE	(5Z,8z,10e,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate (see all 7)	71774-10-2	--
Arachidonic acid	5,8,11,14-Eicosatetraenoic acid (see all 16)	506-32-1	--
Iron	Armco iron (see all 19)	7439-89-6	--
Oxygen	Oxygen (see all 5)	7782-44-7	--

10/81 Novoseek chemical compound relationships for ALOX12 gene (see all 81) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
12-hydroxyeicosatetraenoic acid	96.3	125	10588925 (4), 16514435 (3), 14518561 (3), 17522976 (2) (see all 53)
12-hpete	94.6	21	10830714 (1), 12848295 (1), 16828271 (1), 15474031 (1) (see all 17)
bhpp	91.3	11	10733500 (2), 7593207 (1), 7540838 (1), 9174106 (1) (see all 7)
arachidonic acid	91	216	8829479 (4), 11115402 (4), 19235890 (3), 14518561 (3) (see all 99)
n-benzyl-n-hydroxy-5-phenylpentamide	90.6	4	12874035 (1), 10861450 (1), 11980674 (1)
baicalein	90	55	19439216 (4), 17050058 (4), 17263456 (2), 12874035 (1) (see all 29)
hepoxilin b3	89.4	5	10692117 (3), 2180942 (1), 11851887 (1)
hepoxilin a3	87	4	2106877 (2), 12432937 (1)
12(s)-hydroperoxyeicosatetraenoic acid	84.8	3	8188678 (1), 10588925 (1), 16638750 (1)
13-hydroperoxyoctadecadienoic acid	81.7	2	12218361 (1), 10882192 (1)

Search CenterWatch for drugs/clinical trials and news about ALOX12 / LOX12

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ALOX12 gene:

NM_000697.2

Unigene Cluster for ALOX12:

Arachidonate 12-lipoxygenase

Hs.654431 [show with all ESTs]

Unigene Representative Sequence: NM_000697

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000251535(uc002gdx.4) ENST00000480801 ENST00000406228(uc002gdz.4)

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		hsa-miR-374b* hsa-miR-424 hsa-miR-922 hsa-miR-15a hsa-miR-497 hsa-miR-195 hsa-miR-16 hsa-miR-15b

		SwitchGear 3'UTR luciferase reporter plasmid: ALOX12 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		GenScript: all cDNA clones in your preferred vector: ALOX12 (NM_000697)
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ALOX12
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ALOX12

Additional cDNA sequence:

AF143883.1 BC069557.1 M35418.1 M58704.1 M62982.1 S68587.1 S68588.1

3 DOTS entries:

DT.209219 DT.100019329 DT.91754446

16 AceView cDNA sequences:

AF143883 BC069557 NM_000697 S68587 M62982 M58704 M35418 BG900221

AW374333 BI044580 BV184224 BF773448 T63474 T97387 T63549 T97276

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ALOX12 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAAATGAGTG

About this image

ALOX12 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Liver

Liver Lobule

Liver

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

Line H9 (WA09) (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

Nkx2-1 GFP+ cells (Efficient derivation...)

See ALOX12 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ALOX12

SOURCE GeneReport for Unigene cluster: Hs.654431

SABiosciences Expression via Pathway-Focused PCR Arrays including ALOX12:

Oxidative Stress in human mouse rat

Nitric Oxide Signaling Pathway in human mouse rat

Apoptosis 384HT in human mouse rat

Drug Metabolism in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ALOX12

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALOX12

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for ALOX12 gene from 4/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	--	--	36(a)	possible ortholog	AAWZ02041946(11-4637)
zebrafish (Danio rerio)	Actinopterygii	wufb72a11²	wufb72a11	73.62(n)		322732 BC054621.1
thale cress (Arabidopsis thaliana)	eudicotyledons	LOX6⁶ LOX3⁶ (see all 6)	lipoxygenase 3 (see all 6)	19(a) 18(a) (see all 6)	many ↔ many many ↔ many (see all 6)	1(25319899-25324264) 1(5977411-5981480)
rice (Oryza sativa)	Liliopsida	-- -- (see all 13)	lipozygenase protein, putative, expressed (see all 13)	24(a) 19(a) (see all 13)	many ↔ many many ↔ many (see all 13)	12(22901276-22903277) 3(28084665-28087667)

ENSEMBL Gene Tree for ALOX12 (if available)
TreeFam Gene Tree for ALOX12 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ALOX12 gene

ALOX5² ALOX12B² ALOX15B² ALOX15² ALOXE3²

6 SIMAP similar genes for ALOX12 using alignment to 2 protein entries: LOX12_HUMAN (see all proteins):

arachidonate 12-lipoxygenase ALOX15 ALOX5 ALOX12B ALOX15B ALOXE3

ALOX12 for paralogs About GeneDecksing

3 Pseudogenes.org Pseudogenes for ALOX12
PGOHUM00000237213 PGOHUM00000237343 PGOHUM00000262364

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs76311436^1,2		--	6897436(+)	`AAAATT/CTTGCT`	2	--	int¹ us2k¹		1		EA	120
rs80072428^1,2	C,F,	--	6897456(+)	`ATTCTC/TCCAAC`	2	--	int¹ us2k¹		1		WA	118
rs146306552^1,2		--	6897571(+)	`GCATGC/TGGAGA`	2	--	us2k¹ int¹		0	--	--	--	--
rs190907809^1,2		--	6897701(+)	`GCATGC/TGCAGT`	2	--	us2k¹ int¹		0	--	--	--	--
rs61534907^1,2		--	6897737(+)	`TCATTC/TCCTCT`	2	--	us2k¹ int¹		0	--	--	--	--
rs3840880^1,2	C,F,	--	6897844(-)	`GCCTA-/GAAAAG`	2	--	int¹ us2k¹		3		NS CSA	90
rs202156062^1,2	C	--	6897844(+)	`CTTTTC/TTAGGC`	2	--	int¹ us2k¹		0	--	--	--	--
rs148910740^1,2		--	6897881(+)	`GAAAGA/GCCAGA`	2	--	us2k¹ int¹		0	--	--	--	--
rs183962013^1,2		--	6897963(+)	`ACTGGA/GAGAAC`	2	--	us2k¹ int¹		0	--	--	--	--
rs187395844^1,2		--	6897993(+)	`GACCTA/GCAGTC`	2	--	int¹ us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ALOX12 (6899384 - 6914055 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ALOX12: --
Human Gene Mutation Database (HGMD): ALOX12

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ALOX12 for disorders           About GeneDecksing

OMIM gene information: 152391    OMIM disorders: --

20/59 diseases for ALOX12 (see all 59):    About MalaCards

bronchial asthma spinal cord injury osteoporosis asthma

atherosclerosis inflammatory bowel disease myeloproliferative disorder essential thrombocythemia

essential hypertension esophageal squamous cell carcinoma squamous cell carcinoma diabetes mellitus

rheumatoid arthritis vascular disease thrombocytopenia myocardial infarction

renal cell carcinoma hyperglycemia bipolar disorder ichthyosis

10/41 Novoseek disease relationships for ALOX12 gene (see all 41) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
erythroleukemia	60.9	10	10830714 (2), 2244907 (2), 8443239 (2), 8295977 (1) (see all 7)
carcinoma squamous cell	42.2	20	10428482 (2), 9174106 (2), 9443600 (2), 7525931 (1) (see all 14)
prostate cancer	35.7	61	7624992 (5), 11980674 (5), 10818452 (4), 9321930 (4) (see all 16)
prostate carcinoma	34.7	7	14669797 (3), 10667391 (1), 17443494 (1), 10861450 (1) (see all 5)
atherosclerosis	32	6	17459368 (1), 18296557 (1), 10504415 (1), 11845232 (1) (see all 6)
cancer	29.8	25	12874035 (3), 7825842 (1), 15034803 (1), 16731771 (1) (see all 17)
tumors	27	78	10861450 (4), 14669797 (4), 10818452 (3), 12085962 (3) (see all 36)
skin tumor	24.4	3	15305153 (2), 10667390 (1)
metastasis	22.6	31	14669797 (3), 7712597 (2), 20303950 (2), 12394183 (2) (see all 16)
psoriasis	22.5	9	17521953 (2), 8304420 (1), 16019177 (1), 18755188 (1) (see all 5)

Genetic Association Database (GAD): ALOX12
Human Genome Epidemiology (HuGE) Navigator: ALOX12 (36 documents)

Export disorders for ALOX12 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ALOX12 gene, integrated from 9 sources (see all 394):
(articles sorted by number of sources associating them with ALOX12)

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Arachidonate lipoxygenase (ALOX) and cyclooxygenase (COX) polymorphisms and colon cancer risk. (PubMed id 15308583)^{1, 2, 4} Goodman J.E.... Harris C.C. (2004)
Characterization of human 12-lipoxygenase genes. (PubMed id 1570320)^{1, 2, 3} Funk C.D.... Samuelsson B. (1992)
Cloning of the cDNA for human 12-lipoxygenase. (PubMed id 2217179)^{1, 2, 9} Izumi T.... Samuelsson B. (1990)
Epidermis contains platelet-type 12-lipoxygenase that is overexpressed in germinal layer keratinocytes in psoriasis. (PubMed id 8304420)^{1, 2, 9} Hussain H.... Holtzman M.J. (1994)
Molecular cloning and expression of human arachidonate 12- lipoxygenase. (PubMed id 2244907)^{1, 2, 9} Yoshimoto T.... Toh H. (1990)
Structure and chromosomal localization of human arachidonate 12- lipoxygenase gene. (PubMed id 1447217)^{1, 2, 9} Yoshimoto T.... Takahashi E. (1992)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Association of a new polymorphism in ALOX12 gene with bipolar disorder. (PubMed id 12664313)^{1, 4} Fridman C....Dias Neto E. (2003)
Molecular cloning, primary structure, and expression of the human platelet/erythroleukemia cell 12-lipoxygenase. (PubMed id 2377602)^{1, 2} Funk C.D.... Fitzgerald G.A. (1990)
Increased metastatic potential in human prostate carcinoma cells by overexpression of arachidonate 12-lipoxygenase. (PubMed id 14669797)^{1, 9} Nie D....Honn K.V. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 239	HGNC: 429	AceView: ALOX12	Ensembl:ENSG00000108839	euGenes: HUgn239
ECgene: ALOX12	Kegg: 239	H-InvDB: ALOX12

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ALOX12	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for ALOX12	Genetics and Cytogenetics in Oncology and Haematology
SeattleSNPs	http://pga.gs.washington.edu/data/alox12/

Intellectual Property for ALOX12 gene
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Patent Information for ALOX12 gene:
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GeneCards and IP:
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ALOX12 Gene

arachidonate 12-lipoxygenase

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