Aliases for ALOX12 Gene
External Ids for ALOX12 Gene
Previous GeneCards Identifiers for ALOX12 Gene
GeneCards Summary for ALOX12 Gene
ALOX12 (Arachidonate 12-Lipoxygenase) is a Protein Coding gene. Diseases associated with ALOX12 include Inflammatory Bowel Disease 12 and Colorectal Cancer 12. Among its related pathways are Development Endothelin-1/EDNRA signaling and Arachidonic acid metabolism. GO annotations related to this gene include iron ion binding and arachidonate 12-lipoxygenase activity. An important paralog of this gene is ALOX5.
UniProtKB/Swiss-Prot for ALOX12 Gene
Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Mainly converts arachidonic acid to (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE but can also metabolize linoleic acid. Has a dual activity since it also converts leukotriene A4/LTA4 into both the bioactive lipoxin A4/LXA4 and lipoxin B4/LXB4. Through the production of specific bioactive lipids like (12S)-HPETE it regulates different biological processes including platelet activation. It also probably positively regulates angiogenesis through regulation of the expression of the vascular endothelial growth factor. Plays a role in apoptotic process, promoting the survival of vascular smooth muscle cells for instance. May also play a role in the control of cell migration and proliferation.
Lipoxygenases (LOXs) are a family of non-heme iron dioxygenases that are involved in the production and metabolism of fatty acid hydroperoxidases. There are six lipoxygenase isozymes; 5-LOX, 12R-LOX, 12S-LOX, 15-LOX-1, 15-LOX-2 and E-LOX.