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ALMS1 Gene

protein-coding GIFtS: 57

GC02P073466

Alstrom syndrome 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
ALSS ^², ⁵
DKFZp686A118 ^²
DKFZp686D1828 ^²
KIAA0328 ^¹, ², ³, ⁵

Descriptions
Alstrom syndrome 1 ^²

External Ids
HGNC: 428¹
Entrez Gene: 7840²
UniProtKB: Q8TCU4³
Ensembl: ENSG00000116127⁷

Search outside databases for aliases for ALMS1 gene

Previous GC identifers: GC02P073622 GC02P073823 GC02P073587 GC02P073524

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ALMS1:

This gene encodes a protein containing a large tandem-repeat domain. The mouse ortholog of this

gene has been shown to function in ciliogenesis in inner medullary collecting duct cells.

Mutations in this gene have been associated with Alstrom syndrome. Alternative splice variants

have been described but their full length sequences have not been determined.

UniProtKB/Swiss-Prot: ALMS1_HUMAN, Q8TCU4

Function: Possible role in intracellular trafficking (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ALMS1 gene

Entrez Gene cytogenetic band: 2p13 Ensembl cytogenetic band: 2p13.2 HGNC cytogenetic band: 2p13.1

ALMS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P073466: (about GC identifiers)

Start:	73,466,394 bp from pter
End:	73,690,554 bp from pter
Size:	224,161 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000002.10 NT_022184.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: ALMS1_HUMAN, Q8TCU4 (See protein sequence)

Recommended Name: Alstrom syndrome protein 1

Size: 4167 amino acids; 460937 Da

Subcellular location: Cytoplasm. Centrosome. Cell projection, cilium basal body. Note=Associated

with centrosomes and basal body at the base of primary cilia. During mitosis localizes to both

spindle poles

Developmental stage: Widely expressed in fetal tissues. Detected in fetal pancreas, skeletal

muscle, liver, kidney and brain (at protein level). Expressed in fetal aorta and brain

Secondary accessions: Q53S05 Q580Q8 Q86VP9 Q9Y4G4

Alternative splicing: 3 isoforms: Q8TCU4-1 Q8TCU4-2 Q8TCU4-3

Post-translational modifications:

Phosphorylated upon DNA damage, probably by ATM or ATR¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_055935.4

ENSEMBL proteins:

ENSP00000366944 ENSP00000264448 ENSP00000386627

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (ALMS1)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--
GO:0005813	centrosome	IDA	15855349
GO:0005929	cilium	IEA	--

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Antibodies for ALMS1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (ALMS1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ALMS1)
	Novus Biologicals Antibodies for ALMS1

Assays for ALMS1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q8TCU4

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ALMS1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_015120

Applied Biosystems Silencer® siRNAs for ALMS1

Sigma-Aldrich siRNA for ALMS1

Sigma-Aldrich shRNA for ALMS1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_015120
Myc/DDK tagged cDNA clone in CMV expression vector: NM_015120
untagged cDNA clone in CMV expression vector: NM_015120

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_015120

UniProtKB/Swiss-Prot: ALMS1_HUMAN, Q8TCU4

Function: Possible role in intracellular trafficking (By similarity)

13 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Alms1):

adipose tissue	behavior/neurological	cellular	digestive/alimentary	endocrine/exocrine gland
growth/size	hearing/vestibular/ear	homeostasis/metabolism	immune system	liver/biliary system
renal/urinary system	reproductive system	vision/eye

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003674	molecular_function	ND	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/65 Interacting proteins for ALMS1 (ENSP00000264448³) via UniProtKB, MINT, and/or STRING (see all 65 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DCTN1	ENSP00000354791³	STRING (score=.933)
ACTR1A	ENSP00000358921³	STRING (score=.899)
AZI1	ENSP00000269392³	STRING (score=.899)
CDC2	ENSP00000362917³	STRING (score=.899)
CENPJ	ENSP00000371308³	STRING (score=.899)

About this table

3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007601	visual perception	IEA	--
GO:0007605	sensory perception of sound	IEA	--
GO:0050896	response to stimulus	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ALMS1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ALMS1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_015120

Sigma-Aldrich siRNA for ALMS1

Sigma-Aldrich shRNA for ALMS1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_015120

REFSEQ mRNAs for ALMS1 gene:

NM_015120.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_015120

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_015120
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_015120
                                 untagged cDNA clone in CMV expression vector: NM_015120

Additional cDNA sequence:

AB002326.3 AJ417593.2 AL833495.1 BC035025.2 BC050330.1 BX647706.1 BX648632.1 EF151141.1

13 DOTS entries:

DT.314966 DT.75155839 DT.100816254 DT.92422157 DT.100036543 DT.100671819 DT.99997664 DT.100036545

DT.101963353 DT.121008213 DT.121008226 DT.92422155 DT.95299663

24/146 AceView cDNA sequences (see all 146 ):

AA393282 AW473187 AL044729 BM875441 AI741793 AL704019 AI425117 AL135493

AL041387 BQ017018 NM_015120 AW386108 BM723326 F12602 BC035025 BE891274

AL041386 BQ889511 F10219 BU154288 BM875692 AL833495 BP369149 AJ417593

highest scoring ESTs for ALMS1:

AA425065 AA749051 AA887964 AA913775 AA961070 AB002326 AI223186 AI333124 AI425117 AI452997

Unigene Cluster for ALMS1:

Alstrom syndrome 1

Hs.184720 [show with all ESTs]

Unigene Representative Sequence: AJ417593

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for ALMS1 (see all 8 )

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8a	·	8b	·	8c	·	8d	^	9	^	10	^	11	^	12a	·	12b	·	12c	^	13a	·	13b	·	13c	^	14	^	15	^	16	^	17	^	18	^	19a	·
SP1:																									-		-		-		-		-
SP2:																									-		-		-		-		-
SP3:																									-		-		-		-		-						-
SP4:																									-		-		-		-		-
SP5:

ExUns:	19b	·	19c	^	20	^	21	^	22	^	23	^	24	^	25	^	26a	·	26b	^	27	^	28
SP1:			-		-		-												-
SP2:			-		-		-
SP3:
SP4:
SP5:			-

About this scheme

ECgene alternative splicing isoforms for ALMS1

3 Ensembl transcripts including schematic representations:

ENST00000377715 ENST00000264448 ENST00000409009

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ALMS1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ALMS1

¹ / ² / ³

9 probe-sets matching ALMS1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
38344_at²^{, 3}	U95-A	2	1.00	0.97	0.90	1.13	R40666	0.60	1.00	0.82	1
38343_at²^{, 3}	U95-A	2	1.00	0.69	0.72	0.93	AB002326	0.80	1.00	0.91	1
63114_at²^{, 3}	U95-C	2	0.94	0.70	0.94	0.95	T67466	0.20	1.00	0.72	1
214220_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AW003635	0.80	1.00	0.91	1
214221_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AI825212	0.80	1.00	0.91	1
214707_x_at²^{, 3}	U133-A	27	1.00	0.70	--	--	AB002326	0.80	1.00	0.91	1
214220_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
214221_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
214707_x_at²	U133Plus2	27	1.00	0.70	--	--	--	--	--	--	--

GeneDecks ALMS1 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TGTATTTTAG

SOURCE GeneReport for Unigene cluster: Hs.184720
Expression variation in blood from EXPOLDB for ALMS1
UniProtKB/Swiss-Prot: ALMS1_HUMAN, Q8TCU4
Tissue specificity: Expressed in all tissues tested including adipose and pancreas. Expressed by
beta-cells of the islets in the pancreas (at protein level)

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ALMS1 gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ALMS1¹	--	Alstrom syndrome 1	80.1(n) 67.99(a)	475795 XM_533005.2 XP_533005.2
chimpanzee (Pan troglodytes)	ALMS1¹	--	Alstrom syndrome 1	91.67(n) 83.78(a)	459325 XM_530465.2 XP_530465.2
cow (Bos taurus)	ALMS1¹	--	Alstrom syndrome 1	81.11(n) 69.33(a)	533055 XM_612325.3 XP_612325.3
rat (Rattus norvegicus)	Alms1¹	--	Alstrom syndrome 1 homolog (human)	74.08(n) 59.84(a)	297408 XM_216189.3 XP_216189.3
mouse (Mus musculus)	Alms1^{1, 5}	6⁵	Alstrom syndrome 1 homolog (human)^{1, 5}	74.25(n)¹ 59.79(a)¹	236266¹ NM_145223.1¹ NP_660258.1¹ AF425257⁵ AK041679⁵ (see all 8)

About this table Species with no ortholog for ALMS1

ENSEMBL Gene Tree for ALMS1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ALMS1 gene

ALMS1P²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/1056 NCBI SNPs in ALMS1 are shown (see all 1056 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 292)

AB	SNP ID	Valid	Chr 2 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs2017116^1,2	A,C,F,H,O	73570611(-)	`TTCATC/GGAATG`	1	D/H	mis¹ ese³		16	MN EA NA EU WA	2824
	rs6546838^1,2	A,C,F,H	73532788(+)	`AAGCAA/GTAGGG`	1	I/V	mis¹		12	EU EA WA MN NA	1058
	rs3813227^1,2	A,C,F,H	73505475(+)	`CTGCTC/TGTTCA`	1	R/C	mis¹		13	EA EU WA MN NA	2542
	rs1052161^1,2	A,C,F,H	73682046(-)	`ATGGCC/TTCAGT`	1	R/K	mis¹		18	EA NA MN EU WA	2852
	rs10193972^1,2	A,C,F,H	73571164(+)	`AGTAAA/GCAGAT`	1	N/S	mis¹		12	NA EU EA WA	1050
--	rs6546837^1,2	A,C,F,H	73531406(+)	`ACCAGG/CTGACC`	1	A/G	mis¹		4	EU EA WA	418
	rs2056486^1,2	A,C,F,H	73571075(-)	`TTTGCC/ACTGGT`	1	S/R	mis¹		16	EU EA WA MN NA	1394
	rs7576824^1,2	A,C,F,H	73464789(+)	`ctgttA/Gttaac`	1	--	ng5¹		8	EU EA WA	838
	rs2037814^1,2	A,C,F,H	73529177(-)	`CCTCTC/ACATGT`	1	G/V	mis¹		12	EU EA WA MN NA	1058
	rs6546839^1,2	A,C,F,H	73534016(+)	`TGCCCG/CTTTCA`	1	P/R	mis¹		12	EU EA WA MN NA	1052

About this table

HapMap Linkage Disequilibrium images for ALMS1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 606844 disorders: 203800

UniProtKB/Swiss-Prot: ALMS1_HUMAN, Q8TCU4

Defects in ALMS1 are the cause of Alstrom syndrome (ALMS) [MIM:203800]. Alstrom syndrome

is a rare autosomal recessive disorder characterized by progressive cone-rod retinal dystrophy,

neurosensory hearing loss, early childhood obesity and type 2 diabetes mellitus. Dilated

cardiomyopathy, acanthosis nigricans, male hypogonadism, hypothyroidism, developmental delay and

hepatic dysfunction can also be associated with the syndrome

GeneTests: ALMS1

Alstrom Syndrome

Human Gene Mutation Database: ALMS1
Human Genome Epidemiology Navigator: ALMS1 (2 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/22 PubMed articles for ALMS1 gene (see all 22 ):

Mutation of ALMS1, a large gene with a tandem repeat encoding 47 amino acids, causes Alstrom syndrome. (PubMed id 11941370)^{1, 3, 4} Hearn T.... Wilson D.I. (2002)
Mutations in ALMS1 cause obesity, type 2 diabetes and neurosensory degeneration in Alstrom syndrome. (PubMed id 11941369)^{1, 3, 4} Collin G.B....Naggert J.K. (2002)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)^{3, 4} Hillier L.W....Wilson R.K. (2005)
Subcellular localization of ALMS1 supports involvement of centrosome and basal body dysfunction in the pathogenesis of obesity, insulin resistance, and type 2 diabetes. (PubMed id 15855349)^{3, 4} Hearn T.... Wilson D.I. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Proteomic characterization of the human centrosome by protein correlation profiling. (PubMed id 14654843)^{3, 4} Andersen J.S....Mann M. (2003)
Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)^{3, 4} Nakajima D.... Nagase T. (2002)
Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9205841)^{3, 4} Nagase T....Ohara O. (1997)
Homozygosity mapping at Alstrom syndrome to chromosome 2p. (PubMed id 9063741)^{2, 3} Collin G.B....Nishina P.M. (1997)
Regulation of Alstrom syndrome gene expression during adipogenesis and its relationship with fat cell insulin sensitivity. (PubMed id 18506366)^{1, 3} Romano S....Vettor R. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 7840	HGNC: 428	AceView: ALMS1	Ensembl:ENSG00000116127	euGenes: HUgn7840
ECgene: ALMS1	H-InvDB: ALMS1

(According to HUGE)
About This Section

HUGE: KIAA0328

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
GeneReviews	http://www.genetests.org/query?gene=ALMS1

Licensable Technologies for ALMS1
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ALMS1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ALMS1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ALMS1		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ALMS1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for ALMS1

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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ALMS1 Gene

protein-coding GIFtS: 57

Aliases &
Descriptions
for ALMS1

Summaries
for ALMS1

Genomic Location
for ALMS1

Proteins
for ALMS1

Protein Domains/
Families
for ALMS1

Gene Function
for ALMS1

Pathways & Interactions
for ALMS1

Drugs & Compounds
for ALMS1

Transcripts
for ALMS1

Expression
for ALMS1

Orthologs
for ALMS1

Paralogs
for ALMS1

SNPs/Variants
for ALMS1

Disorders & Mutations
for ALMS1

Medical News
for ALMS1

Publications
for ALMS1

Search for ALMS1

Genome Databases showing ALMS1

Other Databases showing ALMS1

Specialized Databases showing ALMS1

Licensable Technologies
for ALMS1

Services
for ALMS1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ALMS1 Gene

protein-coding GIFtS: 57

Aliases & Descriptionsfor ALMS1

Summariesfor ALMS1

Genomic Locationfor ALMS1

Proteinsfor ALMS1

Protein Domains/Familiesfor ALMS1

Gene Functionfor ALMS1

Pathways & Interactionsfor ALMS1

Drugs & Compoundsfor ALMS1

Transcriptsfor ALMS1

Expression for ALMS1

Orthologsfor ALMS1

Paralogsfor ALMS1

SNPs/Variantsfor ALMS1

Disorders & Mutationsfor ALMS1

Medical Newsfor ALMS1

Publicationsfor ALMS1

Search for ALMS1

Genome Databases showing ALMS1

Other Databases showing ALMS1

Specialized Databases showing ALMS1

Licensable Technologiesfor ALMS1

Servicesfor ALMS1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ALMS1

Summaries
for ALMS1

Genomic Location
for ALMS1

Proteins
for ALMS1

Protein Domains/
Families
for ALMS1

Gene Function
for ALMS1

Pathways & Interactions
for ALMS1

Drugs & Compounds
for ALMS1

Transcripts
for ALMS1

Expression
for ALMS1

Orthologs
for ALMS1

Paralogs
for ALMS1

SNPs/Variants
for ALMS1

Disorders & Mutations
for ALMS1

Medical News
for ALMS1

Publications
for ALMS1

Licensable Technologies
for ALMS1

Services
for ALMS1