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Aliases for ALLC Gene

Aliases for ALLC Gene

  • Allantoicase 2 3
  • Allantoate Amidinohydrolase 3 4
  • EC 4 63
  • Probable Allantoicase 3
  • ALC 3

External Ids for ALLC Gene

Previous GeneCards Identifiers for ALLC Gene

  • GC02P003183
  • GC02P003348
  • GC02P003270
  • GC02P003199
  • GC02P003683

Summaries for ALLC Gene

Entrez Gene Summary for ALLC Gene

  • Allantoicase (EC participates in the uric acid degradation pathway. Its enzymatic activity, like that of urate oxidase (MIM 191540), was lost during vertebrate evolution.[supplied by OMIM, Nov 2008]

GeneCards Summary for ALLC Gene

ALLC (Allantoicase) is a Protein Coding gene. Diseases associated with ALLC include denture stomatitis and lymphogranuloma venereum. Among its related pathways are Metabolism and Purine metabolism (KEGG). GO annotations related to this gene include allantoicase activity.

UniProtKB/Swiss-Prot for ALLC Gene

  • The function of this enzyme is unclear as allantoicase activity is not known to exist in mammals

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ALLC Gene

Genomics for ALLC Gene

Regulatory Elements for ALLC Gene

Genomic Location for ALLC Gene

3,658,195 bp from pter
3,702,671 bp from pter
44,477 bases
Plus strand

Genomic View for ALLC Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ALLC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ALLC Gene

Proteins for ALLC Gene

  • Protein details for ALLC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable allantoicase
    Protein Accession:
    Secondary Accessions:
    • Q53T95
    • Q5RL81
    • Q96RE6
    • Q9NZA7

    Protein attributes for ALLC Gene

    410 amino acids
    Molecular mass:
    45750 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAY24236.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ALLC Gene


neXtProt entry for ALLC Gene

Proteomics data for ALLC Gene at MOPED

Selected DME Specific Peptides for ALLC Gene

Post-translational modifications for ALLC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ALLC Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains for ALLC Gene

Protein Domains for ALLC Gene

Suggested Antigen Peptide Sequences for ALLC Gene

Graphical View of Domain Structure for InterPro Entry



  • Q8N6M5
  • Belongs to the allantoicase family.
genes like me logo Genes that share domains with ALLC: view

No data available for Gene Families for ALLC Gene

Function for ALLC Gene

Molecular function for ALLC Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Allantoate + H(2)O = (S)-ureidoglycolate + urea
UniProtKB/Swiss-Prot Function:
The function of this enzyme is unclear as allantoicase activity is not known to exist in mammals

Enzyme Numbers (IUBMB) for ALLC Gene

Gene Ontology (GO) - Molecular Function for ALLC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004037 allantoicase activity IEA --
genes like me logo Genes that share ontologies with ALLC: view

Phenotypes for ALLC Gene

GenomeRNAi human phenotypes for ALLC:
genes like me logo Genes that share phenotypes with ALLC: view

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ALLC

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ALLC Gene

Localization for ALLC Gene

Subcellular locations from

Jensen Localization Image for ALLC Gene COMPARTMENTS Subcellular localization image for ALLC gene
Compartment Confidence
cytoskeleton 3
extracellular 2
nucleus 2
peroxisome 2
chloroplast 1
cytosol 1
mitochondrion 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ALLC Gene

Pathways for ALLC Gene

SuperPathways for ALLC Gene

Superpath Contained pathways
1 Metabolism
2 Purine metabolism (KEGG)
genes like me logo Genes that share pathways with ALLC: view

Pathways by source for ALLC Gene

2 KEGG pathways for ALLC Gene

Interacting Proteins for ALLC Gene

Selected Interacting proteins: Q8N6M5-ALLC_HUMAN for ALLC Gene via I2D

Gene Ontology (GO) - Biological Process for ALLC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000256 allantoin catabolic process IEA --
genes like me logo Genes that share ontologies with ALLC: view

Compounds for ALLC Gene

(4) HMDB Compounds for ALLC Gene

Compound Synonyms Cas Number PubMed IDs
(S)-Ureidoglycolic acid
  • (-)-Ureidoglycolate
Allantoic acid
  • Allantoate
  • Carbonyl diamine
  • Dihydrogen oxide

(1) Novoseek inferred chemical compound relationships for ALLC Gene

Compound -log(P) Hits PubMed IDs
uric acid 58.4 1
genes like me logo Genes that share compounds with ALLC: view

Transcripts for ALLC Gene

Unigene Clusters for ALLC Gene

Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ALLC

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ALLC Gene

No ASD Table

Relevant External Links for ALLC Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ALLC Gene

mRNA expression in normal human tissues for ALLC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ALLC Gene

This gene is overexpressed in Testis (27.4) and Nerve - Tibial (8.6).

Protein differential expression in normal tissues for ALLC Gene

This gene is overexpressed in Platelet (55.8).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for ALLC Gene

SOURCE GeneReport for Unigene cluster for ALLC Gene Hs.97899

genes like me logo Genes that share expressions with ALLC: view

Expression partners for ALLC Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ALLC Gene

Orthologs for ALLC Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ALLC Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ALLC 35
  • 83.5 (n)
  • 84.87 (a)
  • 76 (a)
(Canis familiaris)
Mammalia ALLC 35
  • 84.27 (n)
  • 84.87 (a)
  • 80 (a)
(Mus musculus)
Mammalia Allc 35
  • 80.17 (n)
  • 80.51 (a)
Allc 16
Allc 36
  • 76 (a)
(Pan troglodytes)
Mammalia ALLC 35
  • 99.06 (n)
  • 98.21 (a)
  • 98 (a)
(Rattus norvegicus)
Mammalia Allc 35
  • 81.28 (n)
  • 81.28 (a)
(Monodelphis domestica)
Mammalia ALLC 36
  • 63 (a)
(Ornithorhynchus anatinus)
Mammalia ALLC 36
  • 61 (a)
(Anolis carolinensis)
Reptilia ALLC 36
  • 53 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia allc 35
  • 64.11 (n)
  • 58.36 (a)
LOC394447 35
African clawed frog
(Xenopus laevis)
Amphibia MGC68581 35
(Danio rerio)
Actinopterygii allc 35
  • 60.93 (n)
  • 56.28 (a)
allc 36
  • 52 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5701 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004501 35
  • 49.81 (n)
  • 48.86 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER162C 35
  • 46.17 (n)
  • 35.6 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B04422g 35
  • 46.92 (n)
  • 36.62 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DAL2 35
  • 46.16 (n)
  • 35.02 (a)
DAL2 36
  • 32 (a)
DAL2 38
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14186 35
bread mold
(Neurospora crassa)
Ascomycetes NCU01816 35
  • 45.95 (n)
  • 36.28 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC1F7.09c 35
  • 48.5 (n)
  • 39.74 (a)
Species with no ortholog for ALLC:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ALLC Gene

Gene Tree for ALLC (if available)
Gene Tree for ALLC (if available)

Paralogs for ALLC Gene

No data available for Paralogs for ALLC Gene

Variants for ALLC Gene

Sequence variations from dbSNP and Humsavar for ALLC Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs872877 -- 3,688,236(+) TGTCA(A/G)GTTTC intron-variant
rs1367277 -- 3,687,915(-) CCCTG(C/T)CACAC intron-variant
rs1594316 -- 3,686,574(-) gttcc(A/G)tgctc intron-variant
rs1594317 -- 3,686,373(-) aaaat(A/G)tacta intron-variant
rs1594318 -- 3,686,354(-) tataa(C/G)caaat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ALLC Gene

Variant ID Type Subtype PubMed ID
nsv873591 CNV Gain 21882294
nsv818922 CNV Gain 17921354
nsv468961 CNV Gain 19166990
dgv4043n71 CNV Gain 21882294
nsv2574 CNV Insertion 18451855
nsv517058 CNV Loss 19592680
nsv873594 CNV Loss 21882294
esv29025 CNV Loss 19812545
esv271682 CNV Insertion 20981092
esv273654 CNV Insertion 20981092
esv2428176 CNV Deletion 19546169
esv2719525 CNV Deletion 23290073
esv2660703 CNV Deletion 23128226
esv2719526 CNV Deletion 23290073
nsv873595 CNV Gain 21882294
nsv523573 CNV Loss 19592680
nsv2575 CNV Loss 18451855
esv2719527 CNV Deletion 23290073
esv2656614 CNV Deletion 23128226
nsv498908 CNV Loss 21111241
esv27648 CNV Loss 19812545
nsv828164 CNV Loss 20364138
esv32895 CNV Loss 17666407

Relevant External Links for ALLC Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ALLC Gene

Disorders for ALLC Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for ALLC Gene in MalaCards »

(2) Diseases for ALLC Gene including...

genes like me logo Genes that share disorders with ALLC: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships , Genatlas and External Links for ALLC Gene

Publications for ALLC Gene

  1. Human allantoicase gene: cDNA cloning, genomic organization and chromosome localization. (PMID: 11054555) Vigetti D. … Bernardini G. (Gene 2000) 2 3 4 23
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4
  4. Genomic organization and chromosome localization of the murine and human allantoicase gene. (PMID: 12036579) Vigetti D. … Bernardini G. (Gene 2002) 3 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for ALLC Gene

Sources for ALLC Gene

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