ALLC Gene
protein-coding GIFtS : 53
GCID: GC02 P003705
allantoicase
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Aliasesfor ALLC gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Allantoicase 1 ALC1 2 Allantoate Amidinohydrolase2 3 EC 3.5.3.43 8 Probable Allantoicase2
Export aliases for ALLC gene to outside databases Previous GC identifers: GC02P003183 GC02P003348 GC02P003270 GC02P003199 GC02P003683
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Summariesfor ALLC gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for ALLC : Allantoicase (EC 3.5.3.4) participates in the uric acid degradation pathway. Its enzymatic activity, like that of urate oxidase (MIM 191540), was lost during vertebrate evolution.(supplied by OMIM, Nov 2008) UniProtKB/Swiss-Prot: ALLC_HUMAN, Q8N6M5 Function : The function of this enzyme is unclear as allantoicase activity is not known to exist in mammals
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Genomic Viewsfor ALLC gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000002.11 NC_018913.1 NT_022139.13 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the ALLC gene promoter: PPAR-gamma1 PPAR-gamma2 Other transcription factors Search SABiosciences Chromatin IP Primers for ALLC Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ALLC
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 2q35 Ensembl cytogenetic band: 2p25.3 HGNC cytogenetic band: 2p25.3 ALLC Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 2 GeneLoc Exon Structure
GeneLoc location for GC02P003705: view genomic region
(about GC identifiers )
Start:
3,705,785 bp from pter
End:
3,750,261 bp from pter
Size:
44,477 bases
Orientation:
plus strand
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Proteinsfor ALLC gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: ALLC_HUMAN, Q8N6M5 (See
protein sequence )Recommended Name: Probable allantoicase Size : 410 amino acids; 45750 Da
Sequence caution : Sequence=AAY24236.1; Type=Erroneous gene model prediction;
Secondary accessions : Q53T95 Q5RL81 Q96RE6 Q9NZA7Alternative splicing : 2 isoforms : Q8N6M5-1 Q8N6M5-2 Explore the universe of human proteins at neXtProt for ALLC: NX_Q8N6M5 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q8N6M5 4/10 DME Specific Peptides for ALLC (Q8N6M5 ) (see all 10 )ALLC Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_060906.3 ENSEMBL proteins: ENSP00000252505 Human Recombinant Protein Products: ALLC Antibody Products: Assay Products for ALLC:
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Protein
Domains / Familiesfor ALLC gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
ALLC for domains About GeneDecksing 3 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q8N6M5 ProtoNet protein and cluster: Q8N6M5
1 Blocks protein family : IPB005164 Allantoicase repeat UniProtKB/Swiss-Prot: ALLC_HUMAN, Q8N6M5 Similarity : Belongs to the allantoicase family
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Functionfor ALLC gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: ALLC_HUMAN, Q8N6M5 Function : The function of this enzyme is unclear as allantoicase activity is not known to exist in mammalsCatalytic activity : Allantoate + H(2)O = (S)-ureidoglycolate + ureaEnzyme Number (IUBMB): EC 3.5.3.4 1 2
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ALLC (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ALLCOriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: ALLC (NM_018436 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ALLC Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ALLC
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALLC
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0004037 allantoicase activity
IEA --
ALLC for ontologies About GeneDecksing 1 GenomeRNAi human phenotype for ALLC :
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Pathways & Interactionsfor ALLC gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways   About this table See pathways by source Super-pathway contained gene-specific pathways 1 Purine metabolism 2 Metabolism
Pathway sources See GeneCards unified pathways Show all pathways 2
Kegg Pathways (Kegg details for ALLC) :
ALLC for pathways About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ALLC 5/10 Interacting proteins for ALLC (Q8N6M5 3 ) via UniProtKB, MINT, STRING, and/or I2D (see all 10 )About this table Gene Ontology (GO): 1 biological process term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0000256 allantoin catabolic process
IEA --
ALLC for ontologies About GeneDecksing
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Drugs & Compoundsfor ALLC gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section
ALLC for compounds About GeneDecksing Browse Tocris compounds for ALLC 4 HMDB Compounds for ALLC About this table 1 Novoseek chemical compound relationship for ALLC gene About this table
Compound
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
uric acid
58.4
2
11330038 (1)
Search CenterWatch for drugs/clinical trials and news about ALLC
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Transcriptsfor ALLC gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
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SwitchGear Genomics ,
GenScript ,
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Primers from
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SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for ALLC gene (2 alternative transcripts): NM_199232.1 NM_018436.3 Unigene Cluster for ALLC:
Allantoicase Hs.97899 [show with all ESTs ] Unigene Representative Sequence: BC035356 3 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000252505 (uc010ewt.3 ) ENST00000476389 (uc002qyf.3 ) ENST00000471711 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ALLC (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ALLCOriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: ALLC (NM_018436 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ALLC Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ALLC
Additional cDNA sequence: AF215924.1 AF395820.1 AK302299.1 BC029652.1 BC035356.1
2 DOTS entries : DT.101976687 DT.100017183
24 AceView cDNA sequences :
NM_199232 AA402997 BC035356 AA421584 BI825480 BC029652 AI910694 BX280147 AF395820 AA469952 BP371512 AI948860 BE465476 NM_018436 BQ189212 AF215924 BX096226 AA708163 AA412027 BQ000277 CK299381 AW886703 BI832436 AI627963 GeneLoc Exon Structure
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Expression for ALLC gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section ALLC expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TTGAAGTTCT
About this image ALLC expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See ALLC Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for ALLC SOURCE GeneReport for Unigene cluster: Hs.97899 SABiosciences Custom PCR Arrays for ALLC Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for ALLCBrowse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat ALLC QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat ALLC QIAGEN QuantiFast Probe-based Assays in human , mouse , rat ALLC In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALLC
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Orthologsfor ALLC gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals and fungi.
Orthologs for ALLC gene from 6/26 species (see all 26 ) About this table
ENSEMBL Gene Tree for ALLC (if available)TreeFam Gene Tree for ALLC (if available)
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Paralogsfor ALLC gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section --
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Genomic Variantsfor ALLC gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 2 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for ALLC (3705785 - 3750261 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 12 variations for ALLC 6 CNVs : 35809 97746 9394 66911 66906 7270 6 Indels : 78384 78385 50460 89428 78386 89429
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing ALLC
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Disorders
/ Diseasesfor ALLC gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
ALLC for disorders About GeneDecksing
OMIM gene information: 612396
OMIM disorders : --10 diseases for ALLC : About MalaCards lymphogranuloma venereum denture stomatitis alcoholic liver cirrhosis campylobacteriosis liver cirrhosis candidiasis stomatitis diarrhea alcoholism malaria 4 diseases from the University of Copenhagen DISEASES database for ALLC :Diabetes mellitus Candidiasis Diarrhea Lymphogranuloma venereum Export disorders for ALLC gene to outside databases
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Publicationsfor ALLC gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for ALLC gene, integrated from 9 sources (see all 11 ): (articles sorted by number of sources associating them with ALLC) Utopia : connect your pdf to the dynamic world of online information
Human allantoicase gene: cDNA cloning, genomic organization and chromosome localization. (PubMed id 11054555) 1 , 2 , 3, 9 Vigetti D.... Bernardini G. (2000) Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621) 1 , 2 Hillier L.W....Wilson R.K. (2005) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Genomic organization and chromosome localization of the murine and human allantoicase gene. (PubMed id 12036579) 1 , 2 Vigetti D.... Bernardini G. (2002) Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560) 1 Kimura K.... Sugano S. (2006) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002) Evolution of urate-degrading enzymes in animal peroxisomes. (PubMed id 11330038) 9 Hayashi S....Noguchi T. (2000) Selective pressure on the allantoicase gene during vertebrate evolution. (PubMed id 14745534) 9 Vigetti D....Gornati R. (2003) A new type of allantoinase in amphibian liver. (PubMed id 11791734) 9 Masuda W....Noguchi T. (2001) Uric acid recycling in the shield bug, Parastrachia japonensis (Hemiptera: Parastrachiidae), during diapause. (PubMed id 16797581) 9 Kashima T....Tojo S. (2006)
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External Searches for ALLC gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing ALLC gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing ALLC gene
(According to HUGE )
About This Section --
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Specialized Databases showing ALLC gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for ALLC Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for ALLC gene: Search GeneIP for patents involving ALLC GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor ALLC gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for ALLC OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for ALLC OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for ALLC OriGene Protein Over-expression Lysate for ALLC Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for ALLC Browse 3'-UTR reporter clones for miRNA target validation OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for ALLC OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for ALLC Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for ALLC OriGene Custom Protein Services for ALLC OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ALLC QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing ALLC QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ALLC QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat ALLC QIAGEN QuantiFast Probe-based Assays in human , mouse , rat ALLC QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat ALLC
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALLC
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ALLC
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