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Aliases for ALLC Gene

Aliases for ALLC Gene

  • Allantoicase 2 3 5
  • Allantoate Amidinohydrolase 3 4
  • EC 4 61
  • Probable Allantoicase 3
  • ALC 3

External Ids for ALLC Gene

Previous GeneCards Identifiers for ALLC Gene

  • GC02P003183
  • GC02P003348
  • GC02P003270
  • GC02P003199
  • GC02P003683

Summaries for ALLC Gene

Entrez Gene Summary for ALLC Gene

  • Allantoicase (EC participates in the uric acid degradation pathway. Its enzymatic activity, like that of urate oxidase (MIM 191540), was lost during vertebrate evolution.[supplied by OMIM, Nov 2008]

GeneCards Summary for ALLC Gene

ALLC (Allantoicase) is a Protein Coding gene. Diseases associated with ALLC include Asymmetric Motor Neuropathy and Neonatal Candidiasis. Among its related pathways are Purine metabolism (KEGG) and Metabolism. GO annotations related to this gene include allantoicase activity.

UniProtKB/Swiss-Prot for ALLC Gene

  • The function of this enzyme is unclear as allantoicase activity is not known to exist in mammals.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ALLC Gene

Genomics for ALLC Gene

Regulatory Elements for ALLC Gene

Enhancers for ALLC Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F003620 1.1 Ensembl ENCODE 10.7 -37.1 -37082 1.0 TBP MLX RARA CREM SP5 PPARG KAT8 MIER3 SMARCA4 RCOR2 COLEC11 RPS7 ALLC PIR38137 TMSB4XP2
GH02F003625 0.9 Ensembl ENCODE 11 -31.4 -31431 1.9 SOX13 SOX5 CTCF TFAP4 FOXA3 ZFP64 RAD21 NR2F2 RARA ETV4 COLEC11 ENSG00000237370 ALLC ADI1 PIR38137 GC02P003645
GH02F003624 0.5 ENCODE 11 -33.6 -33576 0.9 IKZF1 EED EBF1 RELA COLEC11 ENSG00000237370 RPS7 ALLC ADI1 ENSG00000235078 ENSG00000255767 PIR38137 TMSB4XP2
GH02F003667 0.7 FANTOM5 ENCODE 7.1 +9.6 9602 1.5 BHLHE40 RELA ALLC GC02M003688
GH02F003702 0.4 Ensembl 9 +45.7 45684 1.9 EZH2 ALLC ENSG00000227363 DCDC2C LOC105373393
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ALLC on UCSC Golden Path with GeneCards custom track

Genomic Location for ALLC Gene

3,658,184 bp from pter
3,702,671 bp from pter
44,488 bases
Plus strand

Genomic View for ALLC Gene

Genes around ALLC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ALLC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ALLC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ALLC Gene

Proteins for ALLC Gene

  • Protein details for ALLC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable allantoicase
    Protein Accession:
    Secondary Accessions:
    • Q53T95
    • Q5RL81
    • Q96RE6
    • Q9NZA7

    Protein attributes for ALLC Gene

    410 amino acids
    Molecular mass:
    45750 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAY24236.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ALLC Gene


neXtProt entry for ALLC Gene

Selected DME Specific Peptides for ALLC Gene


Post-translational modifications for ALLC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ALLC Gene

Domains & Families for ALLC Gene

Protein Domains for ALLC Gene

Suggested Antigen Peptide Sequences for ALLC Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the allantoicase family.
  • Belongs to the allantoicase family.
genes like me logo Genes that share domains with ALLC: view

No data available for Gene Families for ALLC Gene

Function for ALLC Gene

Molecular function for ALLC Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Allantoate + H(2)O = (S)-ureidoglycolate + urea.
UniProtKB/Swiss-Prot Function:
The function of this enzyme is unclear as allantoicase activity is not known to exist in mammals.

Enzyme Numbers (IUBMB) for ALLC Gene

Gene Ontology (GO) - Molecular Function for ALLC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004037 allantoicase activity IEA --
genes like me logo Genes that share ontologies with ALLC: view
genes like me logo Genes that share phenotypes with ALLC: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ALLC Gene

Localization for ALLC Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ALLC gene
Compartment Confidence
cytoskeleton 3
cytosol 3
plasma membrane 1
extracellular 1
peroxisome 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ALLC Gene

Pathways & Interactions for ALLC Gene

SuperPathway Contained pathways
1 Metabolism
2 Purine metabolism (KEGG)
genes like me logo Genes that share pathways with ALLC: view

Pathways by source for ALLC Gene

2 KEGG pathways for ALLC Gene

Interacting Proteins for ALLC Gene

Selected Interacting proteins: Q8N6M5-ALLC_HUMAN for ALLC Gene via IID

Gene Ontology (GO) - Biological Process for ALLC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000256 allantoin catabolic process IBA --
genes like me logo Genes that share ontologies with ALLC: view

No data available for SIGNOR curated interactions for ALLC Gene

Drugs & Compounds for ALLC Gene

(3) Drugs for ALLC Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Urea Approved Pharma 0
Water Approved Pharma 0

(2) Additional Compounds for ALLC Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(S)-Ureidoglycolic acid
  • (-)-Ureidoglycolate
  • (-)-Ureidoglycolic acid
  • (S)-Ureidoglycolate
  • (S)-Ureidoglycolic acid
  • (S)-[(aminocarbonyl)amino]hydroxy-acetic acid
Allantoic acid
  • Allantoate
  • Allantoic acid
  • Diureidoacetate
  • Diureidoacetic acid
genes like me logo Genes that share compounds with ALLC: view

Transcripts for ALLC Gene

Unigene Clusters for ALLC Gene

Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ALLC Gene

No ASD Table

Relevant External Links for ALLC Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ALLC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ALLC Gene

mRNA differential expression in normal tissues according to GTEx for ALLC Gene

This gene is overexpressed in Testis (x27.4) and Nerve - Tibial (x8.6).

Protein differential expression in normal tissues from HIPED for ALLC Gene

This gene is overexpressed in Platelet (55.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ALLC Gene

Protein tissue co-expression partners for ALLC Gene

NURSA nuclear receptor signaling pathways regulating expression of ALLC Gene:


SOURCE GeneReport for Unigene cluster for ALLC Gene:

genes like me logo Genes that share expression patterns with ALLC: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ALLC Gene

Orthologs for ALLC Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ALLC Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ALLC 34 35
  • 99.06 (n)
(Canis familiaris)
Mammalia ALLC 34 35
  • 84.27 (n)
(Bos Taurus)
Mammalia ALLC 34 35
  • 83.5 (n)
(Rattus norvegicus)
Mammalia Allc 34
  • 81.28 (n)
(Mus musculus)
Mammalia Allc 34 16 35
  • 80.17 (n)
(Monodelphis domestica)
Mammalia ALLC 35
  • 63 (a)
(Ornithorhynchus anatinus)
Mammalia ALLC 35
  • 61 (a)
(Anolis carolinensis)
Reptilia ALLC 35
  • 53 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia allc 34
  • 64.11 (n)
LOC394447 34
African clawed frog
(Xenopus laevis)
Amphibia MGC68581 34
(Danio rerio)
Actinopterygii allc 34 35
  • 60.93 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5701 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004501 34
  • 49.81 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B04422g 34
  • 46.92 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER162C 34
  • 46.17 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DAL2 34 35 37
  • 46.16 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC1F7.09c 34
  • 48.5 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU01816 34
  • 45.95 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14186 34
Species where no ortholog for ALLC was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ALLC Gene

Gene Tree for ALLC (if available)
Gene Tree for ALLC (if available)

Paralogs for ALLC Gene

No data available for Paralogs for ALLC Gene

Variants for ALLC Gene

Sequence variations from dbSNP and Humsavar for ALLC Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs387907075 Pathogenic 3,643,807(+) AGCTG(C/T)CCTGC nc-transcript-variant, upstream-variant-2KB, reference, missense
rs387907076 Pathogenic 3,643,912(+) TCATC(A/G)GCATC nc-transcript-variant, upstream-variant-2KB, reference, missense
rs10164415 -- 3,655,929(+) AGCGC(G/T)GCAAA intron-variant, utr-variant-5-prime
rs10164500 -- 3,691,354(+) gctca(A/G)atgat intron-variant
rs10164529 -- 3,656,050(+) AAGAG(C/T)GGACA intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for ALLC Gene

Variant ID Type Subtype PubMed ID
nsv828164 CNV loss 20364138
nsv818922 CNV gain 17921354
nsv580825 CNV gain 21841781
nsv580822 CNV gain 21841781
nsv523573 CNV loss 19592680
nsv517058 CNV loss 19592680
nsv498908 CNV loss 21111241
nsv468961 CNV gain 19166990
nsv2575 CNV deletion 18451855
nsv2574 CNV insertion 18451855
nsv1144888 CNV deletion 24896259
nsv1013223 CNV gain 25217958
esv3589665 CNV loss 21293372
esv3589663 CNV loss 21293372
esv3583623 CNV loss 25503493
esv3583622 CNV loss 25503493
esv3551722 CNV deletion 23714750
esv3360936 CNV insertion 20981092
esv3321672 CNV insertion 20981092
esv3309382 CNV mobile element insertion 20981092
esv3307408 CNV mobile element insertion 20981092
esv32895 CNV loss 17666407
esv29025 CNV loss 19812545
esv27648 CNV loss 19812545
esv2763276 CNV gain+loss 21179565
esv2760637 CNV loss 21179565
esv2719527 CNV deletion 23290073
esv2719526 CNV deletion 23290073
esv2719525 CNV deletion 23290073
esv2660703 CNV deletion 23128226
esv2656614 CNV deletion 23128226
esv2428176 CNV deletion 19546169
dgv6666n54 CNV loss 21841781
dgv6665n54 CNV loss 21841781
dgv6664n54 CNV loss 21841781
dgv3702n100 CNV gain 25217958

Variation tolerance for ALLC Gene

Residual Variation Intolerance Score: 95.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.72; 95.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ALLC Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ALLC Gene

Disorders for ALLC Gene

MalaCards: The human disease database

(6) MalaCards diseases for ALLC Gene - From: DISEASES

Disorder Aliases PubMed IDs
asymmetric motor neuropathy
neonatal candidiasis
  • neonatal candida infection
immature cataract
  • incipient cataract
- elite association - COSMIC cancer census association via MalaCards
Search ALLC in MalaCards View complete list of genes associated with diseases

Relevant External Links for ALLC

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ALLC: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ALLC Gene

Publications for ALLC Gene

  1. Human allantoicase gene: cDNA cloning, genomic organization and chromosome localization. (PMID: 11054555) Vigetti D. … Bernardini G. (Gene 2000) 2 3 4 22 64
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Genomic organization and chromosome localization of the murine and human allantoicase gene. (PMID: 12036579) Vigetti D. … Bernardini G. (Gene 2002) 3 4 64
  5. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3 64

Products for ALLC Gene

Sources for ALLC Gene

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