Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ALLC Gene

Aliases for ALLC Gene

  • Allantoicase 2 3 5
  • Allantoate Amidinohydrolase 3 4
  • EC 4 63
  • ALC 3

External Ids for ALLC Gene

Previous GeneCards Identifiers for ALLC Gene

  • GC02P003183
  • GC02P003348
  • GC02P003270
  • GC02P003199
  • GC02P003683

Summaries for ALLC Gene

Entrez Gene Summary for ALLC Gene

  • Allantoicase (EC participates in the uric acid degradation pathway. Its enzymatic activity, like that of urate oxidase (MIM 191540), was lost during vertebrate evolution.[supplied by OMIM, Nov 2008]

GeneCards Summary for ALLC Gene

ALLC (Allantoicase) is a Protein Coding gene. Diseases associated with ALLC include Asymmetric Motor Neuropathy and Neonatal Candidiasis. Among its related pathways are Metabolism and Pyrimidine metabolism (KEGG). GO annotations related to this gene include allantoicase activity.

UniProtKB/Swiss-Prot for ALLC Gene

  • The function of this enzyme is unclear as allantoicase activity is not known to exist in mammals.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ALLC Gene

Genomics for ALLC Gene

Regulatory Elements for ALLC Gene

Enhancers for ALLC Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ALLC on UCSC Golden Path with GeneCards custom track

Genomic Location for ALLC Gene

3,658,184 bp from pter
3,702,671 bp from pter
44,488 bases
Plus strand

Genomic View for ALLC Gene

Genes around ALLC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ALLC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ALLC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ALLC Gene

Proteins for ALLC Gene

  • Protein details for ALLC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable allantoicase
    Protein Accession:
    Secondary Accessions:
    • Q53T95
    • Q5RL81
    • Q96RE6
    • Q9NZA7

    Protein attributes for ALLC Gene

    410 amino acids
    Molecular mass:
    45750 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAY24236.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ALLC Gene


neXtProt entry for ALLC Gene

Proteomics data for ALLC Gene at MOPED

Selected DME Specific Peptides for ALLC Gene

Post-translational modifications for ALLC Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ALLC Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for ALLC Gene

Protein Domains for ALLC Gene

Suggested Antigen Peptide Sequences for ALLC Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the allantoicase family.
  • Belongs to the allantoicase family.
genes like me logo Genes that share domains with ALLC: view

No data available for Gene Families for ALLC Gene

Function for ALLC Gene

Molecular function for ALLC Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Allantoate + H(2)O = (S)-ureidoglycolate + urea.
UniProtKB/Swiss-Prot Function:
The function of this enzyme is unclear as allantoicase activity is not known to exist in mammals.

Enzyme Numbers (IUBMB) for ALLC Gene

genes like me logo Genes that share phenotypes with ALLC: view

Animal Model Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ALLC Gene

Localization for ALLC Gene

Subcellular locations from

Jensen Localization Image for ALLC Gene COMPARTMENTS Subcellular localization image for ALLC gene
Compartment Confidence
cytoskeleton 3
cytosol 3
extracellular 2
nucleus 1
peroxisome 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ALLC Gene

Pathways & Interactions for ALLC Gene

SuperPathways for ALLC Gene

genes like me logo Genes that share pathways with ALLC: view

Pathways by source for ALLC Gene

2 KEGG pathways for ALLC Gene

Interacting Proteins for ALLC Gene

Selected Interacting proteins: Q8N6M5-ALLC_HUMAN for ALLC Gene via I2D

Gene Ontology (GO) - Biological Process for ALLC Gene


No data available for SIGNOR curated interactions for ALLC Gene

Drugs & Compounds for ALLC Gene

(2) Drugs for ALLC Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Urea Experimental Pharma 0

(3) Additional Compounds for ALLC Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(S)-Ureidoglycolic acid
  • (-)-Ureidoglycolate
  • (-)-Ureidoglycolic acid
  • (S)-Ureidoglycolate
  • (S)-Ureidoglycolic acid
  • (S)-[(aminocarbonyl)amino]hydroxy-acetic acid
Allantoic acid
  • Allantoate
  • Allantoic acid
  • Diureidoacetate
  • Diureidoacetic acid
  • Dihydrogen oxide
  • Steam
genes like me logo Genes that share compounds with ALLC: view

Transcripts for ALLC Gene

Unigene Clusters for ALLC Gene

Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ALLC Gene

No ASD Table

Relevant External Links for ALLC Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ALLC Gene

mRNA expression in normal human tissues for ALLC Gene

mRNA differential expression in normal tissues according to GTEx for ALLC Gene

This gene is overexpressed in Testis (x27.4) and Nerve - Tibial (x8.6).

Protein differential expression in normal tissues from HIPED for ALLC Gene

This gene is overexpressed in Platelet (55.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ALLC Gene

SOURCE GeneReport for Unigene cluster for ALLC Gene Hs.97899

genes like me logo Genes that share expression patterns with ALLC: view

Protein tissue co-expression partners for ALLC Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ALLC Gene

Orthologs for ALLC Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ALLC Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ALLC 35
  • 83.5 (n)
  • 84.87 (a)
  • 76 (a)
(Canis familiaris)
Mammalia ALLC 35
  • 84.27 (n)
  • 84.87 (a)
  • 80 (a)
(Mus musculus)
Mammalia Allc 35
  • 80.17 (n)
  • 80.51 (a)
Allc 16
Allc 36
  • 76 (a)
(Pan troglodytes)
Mammalia ALLC 35
  • 99.06 (n)
  • 98.21 (a)
  • 98 (a)
(Rattus norvegicus)
Mammalia Allc 35
  • 81.28 (n)
  • 81.28 (a)
(Monodelphis domestica)
Mammalia ALLC 36
  • 63 (a)
(Ornithorhynchus anatinus)
Mammalia ALLC 36
  • 61 (a)
(Anolis carolinensis)
Reptilia ALLC 36
  • 53 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia allc 35
  • 64.11 (n)
  • 58.36 (a)
LOC394447 35
African clawed frog
(Xenopus laevis)
Amphibia MGC68581 35
(Danio rerio)
Actinopterygii allc 35
  • 60.93 (n)
  • 56.28 (a)
allc 36
  • 52 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5701 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004501 35
  • 49.81 (n)
  • 48.86 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER162C 35
  • 46.17 (n)
  • 35.6 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B04422g 35
  • 46.92 (n)
  • 36.62 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DAL2 35
  • 46.16 (n)
  • 35.02 (a)
DAL2 36
  • 32 (a)
DAL2 38
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14186 35
bread mold
(Neurospora crassa)
Ascomycetes NCU01816 35
  • 45.95 (n)
  • 36.28 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC1F7.09c 35
  • 48.5 (n)
  • 39.74 (a)
Species with no ortholog for ALLC:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ALLC Gene

Gene Tree for ALLC (if available)
Gene Tree for ALLC (if available)

Paralogs for ALLC Gene

No data available for Paralogs for ALLC Gene

Variants for ALLC Gene

Sequence variations from dbSNP and Humsavar for ALLC Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1594316 -- 3,686,574(-) gttcc(A/G)tgctc intron-variant
rs1594317 -- 3,686,373(-) aaaat(A/G)tacta intron-variant
rs1594318 -- 3,686,354(-) tataa(C/G)caaat intron-variant
rs872877 -- 3,688,236(+) TGTCA(A/G)GTTTC intron-variant
rs1965732 -- 3,661,518(+) TGAGT(A/G)TTCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ALLC Gene

Variant ID Type Subtype PubMed ID
nsv873591 CNV Gain 21882294
nsv818922 CNV Gain 17921354
nsv468961 CNV Gain 19166990
dgv4043n71 CNV Gain 21882294
nsv2574 CNV Insertion 18451855
nsv517058 CNV Loss 19592680
nsv873594 CNV Loss 21882294
esv29025 CNV Loss 19812545
esv271682 CNV Insertion 20981092
esv273654 CNV Insertion 20981092
esv2428176 CNV Deletion 19546169
esv2719525 CNV Deletion 23290073
esv2660703 CNV Deletion 23128226
esv2719526 CNV Deletion 23290073
nsv873595 CNV Gain 21882294
nsv523573 CNV Loss 19592680
nsv2575 CNV Loss 18451855
esv2719527 CNV Deletion 23290073
esv2656614 CNV Deletion 23128226
nsv498908 CNV Loss 21111241
esv27648 CNV Loss 19812545
nsv828164 CNV Loss 20364138
esv32895 CNV Loss 17666407

Variation tolerance for ALLC Gene

Residual Variation Intolerance Score: 95.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.72; 95.76% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ALLC Gene

Disorders for ALLC Gene

MalaCards: The human disease database

(6) MalaCards diseases for ALLC Gene - From: DISEASES

Disorder Aliases PubMed IDs
asymmetric motor neuropathy
neonatal candidiasis
  • neonatal candida infection
  • balanoposthitis of animal
motor neuritis
  • peripheral motor neuropathy
- elite association - COSMIC cancer census association via MalaCards
Search ALLC in MalaCards View complete list of genes associated with diseases

Relevant External Links for ALLC

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ALLC: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ALLC Gene

Publications for ALLC Gene

  1. Human allantoicase gene: cDNA cloning, genomic organization and chromosome localization. (PMID: 11054555) Vigetti D. … Bernardini G. (Gene 2000) 2 3 4 23 67
  2. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3
  3. Genome-wide association study identifies ALLC polymorphisms correlated with FEVa88 change by corticosteroid. (PMID: 24792382) Park T.J. … Shin H.D. (Clin. Chim. Acta 2014) 3
  4. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for ALLC Gene

Sources for ALLC Gene