Aliases for ALKBH8 Gene
- AlkB, Alkylation Repair Homolog 8 (E. Coli) 2 3
- ABH8 3 4 6
- S-Adenosyl-L-Methionine-Dependent TRNA Methyltransferase ABH8 3 4
- TRNA (Carboxymethyluridine(34)-5-O)-Methyltransferase ABH8 3 4
- Probable Alpha-Ketoglutarate-Dependent Dioxygenase ABH8 3 4
- Alkylated DNA Repair Protein AlkB Homolog 8 3
- AlkB Homologue 8 3
- EC 1.14.11.- 4
- EC 220.127.116.11 4
External Ids for ALKBH8 Gene
Previous GeneCards Identifiers for ALKBH8 Gene
GeneCards Summary for ALKBH8 Gene
ALKBH8 (AlkB, Alkylation Repair Homolog 8 (E. Coli)) is a Protein Coding gene. GO annotations related to this gene include RNA binding and tRNA (uracil) methyltransferase activity. An important paralog of this gene is KIAA1456.
UniProtKB/Swiss-Prot for ALKBH8 Gene
Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its methyltransferase domain (PubMed:20123966, PubMed:20308323). Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA (PubMed:20123966, PubMed:20308323). Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys)(PubMed:20308323). Binds tRNA and catalyzes the iron and alpha-ketoglutarate dependent hydroxylation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its dioxygenase domain, giving rise to 5-(S)-methoxycarbonylhydroxymethyluridine; has a preference for tRNA(Gly) (PubMed:21285950). Required for normal survival after DNA damage (PubMed:20308323). May inhibit apoptosis and promote cell survival and angiogenesis (PubMed:19293182).