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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ALKBH7 Gene

protein-coding   GIFtS: 43
GCID: GC19P006372

AlkB, Alkylation Repair Homolog 7 (E. Coli)

(Previous name: spermatogenesis associated 11)
(Previous symbol: SPATA11)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
AlkB, Alkylation Repair Homolog 7 (E. Coli)1 2     Spermatogenesis-Associated Protein 112 3
SPATA111 2 3     UNQ60022
ABH72 3 5     Alpha-Ketoglutarate-Dependent Dioxygenase AlkB Homolog 7, Mitochondrial2
Spermatogenesis Associated 111 2     Probable Alpha-Ketoglutarate-Dependent Dioxygenase ABH72
Alkylated DNA Repair Protein AlkB Homolog 72 3     Spermatogenesis Cell Proliferation Related Protein2
Spermatogenesis Cell Proliferation-Related Protein2 3     EC 1.14.11.-3

External Ids:    HGNC: 213061   Entrez Gene: 842662   Ensembl: ENSG000001256527   OMIM: 6133055   UniProtKB: Q9BT303   

Export aliases for ALKBH7 gene to outside databases

Previous GC identifers: GC19P006324 GC19P006132


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ALKBH7 Gene: 
ALKBH7 (alkB, alkylation repair homolog 7 (E. coli)) is a protein-coding gene. Diseases associated with ALKBH7 include prostatitis, and breast cancer. GO annotations related to this gene include oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors and oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen.

UniProtKB/Swiss-Prot: ALKB7_HUMAN, Q9BT30
Function: Probable dioxygenase that requires molecular oxygen, alpha-ketoglutarate and iron (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011255.14  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ALKBH7 gene promoter:
         AML1a   SREBP-1c   NRSF form 1   MyoD   NRSF form 2   YY1   SREBP-1b   GATA-1   SREBP-1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidALKBH7 promoter sequence
   Search SABiosciences Chromatin IP Primers for ALKBH7

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ALKBH7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

ALKBH7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ALKBH7 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P006372:  view genomic region     (about GC identifiers)

Start:
6,372,444 bp from pter      End:
6,375,261 bp from pter
Size:
2,818 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ALKB7_HUMAN, Q9BT30 (See protein sequence)
Recommended Name: Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7 precursor  
Size: 221 amino acids; 24516 Da
Cofactor: Binds 1 Fe(2+) ion per subunit (By similarity)
Subcellular location: Cytoplasm. Nucleus. Secreted (Potential). Note=Has a predicted N-terminal signal sequence,
indicating it may be secreted. Detected in cytoplasm and nucleus when expressed as fusion protein with an
N-terminal tag (PubMed:17979886)
Secondary accessions: B2R4U9 Q53FF3

Explore the universe of human proteins at neXtProt for ALKBH7: NX_Q9BT30

Explore proteomics data for ALKBH7 at MOPED 

ALKBH7 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

ALKBH7 Protein Expression

REFSEQ proteins: NP_115682.1  
ENSEMBL proteins: 
 ENSP00000245812   ENSP00000470542   ENSP00000470562  

Human Recombinant Protein Products for ALKBH7: 
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OriGene Purified Protein for ALKBH7
OriGene Protein Over-expression Lysate for ALKBH7
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GenScript Custom Purified and Recombinant Proteins Services for ALKBH7
Novus Biologicals ALKBH7 Protein
Novus Biologicals ALKBH7 Lysate
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates 
Browse ProSpec Recombinant Proteins
Cloud-Clone Corp. Proteins for ALKBH7 

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region ----
GO:0005634nucleus ----
GO:0005739mitochondrion ----
GO:0005759mitochondrial matrix IDA--

ALKBH7 for ontologies           About GeneDecksing



ALKBH7 Antibody Products: 
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Assay Products for ALKBH7: 
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Cloud-Clone Corp. ELISAs for ALKBH7 
Cloud-Clone Corp. CLIAs for ALKBH7


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
ALKB: Alkylation repair homologs

1 InterPro protein domain:
 IPR027450 AlkB-like

Graphical View of Domain Structure for InterPro Entry Q9BT30

ProtoNet protein and cluster: Q9BT30

UniProtKB/Swiss-Prot: ALKB7_HUMAN, Q9BT30
Similarity: Belongs to the alkB family


ALKBH7 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: ALKB7_HUMAN, Q9BT30
Function: Probable dioxygenase that requires molecular oxygen, alpha-ketoglutarate and iron (By similarity)

     Enzyme Number (IUBMB): EC 1.14.11.-1

     Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016702oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ----
GO:0046872metal ion binding IEA--
GO:0051213dioxygenase activity IEA--
     
ALKBH7 for ontologies           About GeneDecksing


Phenotypes:
     2 GenomeRNAi human phenotypes for ALKBH7:
 Synthetic lethal with Ras  Synthetic lethal with c-Myc af 

Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for ALKBH7 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ALKBH7

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ALKBH7 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ALKBH7 

miRNA
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Inhib. RNA
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OriGene RNAi products in human, mouse, rat for ALKBH7
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Gene Editing
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Sirion Biotech Customized adenovirus for overexpression of ALKBH7

Clone
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OriGene clones in human, mouse for ALKBH7 (see all 8)
OriGene ORF clones in mouse, rat for ALKBH7
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: ALKBH7 (NM_032306)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for ALKBH7
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALKBH7
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                     Customized lentivirus expression plasmids for stable overexpression of ALKBH7 

Cell Line
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Search LifeMap BioReagents cell lines for ALKBH7
In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALKBH7


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ALKBH7

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

3 Interacting proteins for ALKBH7 (Q9BT303 ENSP000002458124) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
ESR1P033723, ENSP000002062494I2D: score=1 STRING: ENSP00000206249
RABGGTBP536113I2D: score=5 
HDAC1ENSP000003626494STRING: ENSP00000362649
About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006631fatty acid metabolic process ISS--
GO:0006974response to DNA damage stimulus IDA--
GO:0010883regulation of lipid storage ISS--
GO:0070265necrotic cell death IMP--

ALKBH7 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ALKBH7 (ALKB7)

Search CenterWatch for drugs/clinical trials and news about ALKBH7 / ALKB7

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ALKBH7 gene: 
NM_032306.3  

Unigene Cluster for ALKBH7:

AlkB, alkylation repair homolog 7 (E. coli)
Hs.111099  [show with all ESTs]
Unigene Representative Sequence: NM_032306
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000245812(uc002meo.2) ENST00000596657 ENST00000599849
miRNA
Products:
     
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ALKBH7
Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ALKBH7
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for ALKBH7
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ALKBH7
Clone
Products:
     
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OriGene ORF clones in mouse, rat for ALKBH7
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: ALKBH7 (NM_032306)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for ALKBH7
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALKBH7
Sirion Biotech Customized lentivirus for stable overexpression of ALKBH7 
                     Customized lentivirus expression plasmids for stable overexpression of ALKBH7 
Primer
Products:
    
OriGene qPCR primer pairs and template standards for ALKBH7
OriGene qSTAR qPCR primer pairs in human, mouse for ALKBH7
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ALKBH7
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ALKBH7
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ALKBH7

Additional mRNA sequence: 

AF086415.1 AK223336.1 AK311956.1 AY358858.1 AY427650.2 BC004393.1 

6 DOTS entries:

DT.100837956  DT.75173468  DT.92422838  DT.97861638  DT.95213128  DT.100779153 

24/314 AceView cDNA sequences (see all 314):

CD174650 AI096345 AI356002 BQ431202 AI597859 AI685803 AI291782 CK904178 
BM703705 AI809441 AI797507 BM691810 AI805828 NM_032306 AI214824 AI432343 
AW173126 AI699340 AW627934 AI309764 AI343268 AI347496 AW007055 AI362698 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ALKBH7 expression in normal human tissues (normalized intensities)      ALKBH7 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GGGCCAGGGG
ALKBH7 Expression
About this image


ALKBH7 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/2 selected tissues (see all 2) fully expand
 
 Gut Tube (Gastrointestinal Tract)
         Definitive endoderm-like cells ( A scalable, suspension protocol for derivation of...
 
 Testis (Reproductive System)

See ALKBH7 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ALKBH7

SOURCE GeneReport for Unigene cluster: Hs.111099

UniProtKB/Swiss-Prot: ALKB7_HUMAN, Q9BT30
Tissue specificity: Widely expressed, with highest expression in pancreas, followed by spleen, prostate, ovary and
placenta

    SABiosciences Custom PCR Arrays for ALKBH7
Primer
Products:
OriGene qPCR primer pairs and template standards for ALKBH7
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QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ALKBH7
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ALKBH7
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALKBH7

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for ALKBH7 gene from 6/12 species (see all 12)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Alkbh71 , 5 alkB, alkylation repair homolog 7 (E. coli)1, 5 80.54(n)1
81.9(a)1
  17 (29.61 cM)5
664001  NM_025538.31  NP_079814.11 
 569973395 
lizard
(Anolis carolinensis)
Reptilia ALKBH76
Uncharacterized protein
63(a)
1 ↔ 1
2(76461810-76468893)
tropical clawed frog
(Xenopus tropicalis)
Amphibia Str.172662 Transcribed sequence with weak similarity to protein more 68.85(n)    141991766 
zebrafish
(Danio rerio)
Actinopterygii alkbh71 alkB, alkylation repair homolog 7 (E. coli) 57.02(n)
57.37(a)
  550272  NM_001017609.1  NP_001017609.1 
fruit fly
(Drosophila melanogaster)
Insecta CG141301 CG14130 59.44(n)
54.22(a)
  39335  NM_140254.2  NP_648511.2 
worm
(Caenorhabditis elegans)
Secernentea CELE_Y46G5A.351 Protein Y46G5A.35 49.16(n)
43.58(a)
  3564894  NM_001027271.1  NP_001022442.1 


ENSEMBL Gene Tree for ALKBH7 (if available)
TreeFam Gene Tree for ALKBH7 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/120 SNPs in ALKBH7 are shown (see all 120)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 19 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
VAR_0482244
----see VAR_0482242 R Q mis40--------
rs1436126341,2
--6370447(+) ATGGCA/GTGAAC 1 -- us2k10--------
rs1114592901,2
C,F--6370515(+) CACTCC/TAGCCT 1 -- us2k12Minor allele frequency- T:0.50WA CSA 4
rs569448041,2
C,F--6370698(+) GTGGAT/CCCAGA 1 -- us2k12Minor allele frequency- C:0.10WA NA 238
rs735638631,2
C--6370832(+) GCAAGG/CATTCG 1 -- us2k11Minor allele frequency- C:0.50WA 2
rs1477051071,2
C--6370847(+) GGGTC-/GGGGGG 1 -- us2k10--------
rs1931229651,2
C--6370850(+) GTCGGA/GGGGGC 1 -- us2k10--------
rs1169128881,2
C,F--6370875(+) TTACAG/ATGTTG 1 -- us2k11Minor allele frequency- A:0.02NA 120
rs81059171,2
C,F--6371025(+) agaggG/AagaAA 1 -- us2k1 tfbs3 trp32Minor allele frequency- A:0.02WA NA 238
rs1855561561,2
--6371030(+) GAGAAA/GATAAT 1 -- us2k10--------

HapMap Linkage Disequilibrium report for ALKBH7 (6372444 - 6375261 bp)

Structural Variations
     Database of Genomic Variants (DGV) 5 variations for ALKBH7:    About this table     
Variant IDTypeSubtypePubMed ID
dgv3699n71CNV Loss21882294
nsv910916CNV Loss21882294
dgv3700n71CNV Loss21882294
nsv910911CNV Loss21882294
dgv3698n71CNV Loss21882294

SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing ALKBH7
DNA2.0 Custom Variant and Variant Library Synthesis for ALKBH7

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 613305    OMIM disorders: --

2 diseases for ALKBH7:    About MalaCards
prostatitis    breast cancer


ALKBH7 for disorders           About GeneDecksing


Export disorders for ALKBH7 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for ALKBH7 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with ALKBH7)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
  4. Human ALKBH7 is required for alkylation and oxidation- induced programmed necrosis. (PubMed id 23666923)1 Fu D....Samson L.D. (2013)
  5. Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
  6. Identification of proteins associated with ligand-acti vated estrogen receptor a in human breast cancer cell nuclei by tandem affinity purification and nano LC-MS/MS. (PubMed id 21182205)1 Tarallo R....Weisz A. (2011)
  7. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
  8. Expression and sub-cellular localization of human ABH family molecules. (PubMed id 17979886)2 Tsujikawa K....Yamamoto H. (2007)
  9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
  10. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 84266 HGNC: 21306 AceView: SPATA11 Ensembl:ENSG00000125652 euGenes: HUgn84266
ECgene: ALKBH7 H-InvDB: ALKBH7

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for ALKBH7 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for ALKBH7 gene:
Search GeneIP for patents involving ALKBH7

GeneCards and IP:
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(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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 Regulatory tfbs in ALKBH7 promoter
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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(GIFtS: 73)
transforming growth factor, beta 1
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Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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