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Aliases for ALKBH7 Gene

Aliases for ALKBH7 Gene

  • AlkB Homolog 7 2 3 5
  • Spermatogenesis Cell Proliferation-Related Protein 3 4
  • Alkylated DNA Repair Protein AlkB Homolog 7 3 4
  • Spermatogenesis-Associated Protein 11 3 4
  • Spermatogenesis Associated 11 2 3
  • SPATA11 3 4
  • ABH7 3 4
  • Probable Alpha-Ketoglutarate-Dependent Dioxygenase ABH7 3
  • Spermatogenesis Cell Proliferation Related Protein 3
  • AlkB, Alkylation Repair Homolog 7 (E. Coli) 2
  • AlkB, Alkylation Repair Homolog 7 3
  • EC 1.14.11.- 4
  • UNQ6002 3

External Ids for ALKBH7 Gene

Previous HGNC Symbols for ALKBH7 Gene

  • SPATA11

Previous GeneCards Identifiers for ALKBH7 Gene

  • GC19P006324
  • GC19P006132

Summaries for ALKBH7 Gene

GeneCards Summary for ALKBH7 Gene

ALKBH7 (AlkB Homolog 7) is a Protein Coding gene. GO annotations related to this gene include dioxygenase activity.

UniProtKB/Swiss-Prot for ALKBH7 Gene

  • May function as protein hydroxylase; can catalyze auto-hydroxylation at Leu-110 (in vitro), but this activity may be due to the absence of the true substrate (PubMed:25122757). Required to induce programmed necrosis in response to DNA damage caused by cytotoxic alkylating agents. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death (PubMed:23666923). ALKBH7-mediated necrosis is probably required to prevent the accumulation of cells with DNA damage (PubMed:23666923). Does not display DNA demethylase activity (PubMed:23666923). Involved in fatty acid metabolism (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ALKBH7 Gene

Genomics for ALKBH7 Gene

Regulatory Elements for ALKBH7 Gene

Promoters for ALKBH7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ALKBH7 on UCSC Golden Path with GeneCards custom track

Genomic Location for ALKBH7 Gene

Chromosome:
19
Start:
6,372,433 bp from pter
End:
6,375,251 bp from pter
Size:
2,819 bases
Orientation:
Plus strand

Genomic View for ALKBH7 Gene

Genes around ALKBH7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ALKBH7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ALKBH7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ALKBH7 Gene

Proteins for ALKBH7 Gene

  • Protein details for ALKBH7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BT30-ALKB7_HUMAN
    Recommended name:
    Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial
    Protein Accession:
    Q9BT30
    Secondary Accessions:
    • B2R4U9
    • Q53FF3

    Protein attributes for ALKBH7 Gene

    Size:
    221 amino acids
    Molecular mass:
    24516 Da
    Cofactor:
    Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for ALKBH7 Gene

neXtProt entry for ALKBH7 Gene

Proteomics data for ALKBH7 Gene at MOPED

Post-translational modifications for ALKBH7 Gene

No Post-translational modifications

Other Protein References for ALKBH7 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ALKBH7 (ALKBH7)

No data available for DME Specific Peptides for ALKBH7 Gene

Domains & Families for ALKBH7 Gene

Gene Families for ALKBH7 Gene

Protein Domains for ALKBH7 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ALKBH7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BT30

UniProtKB/Swiss-Prot:

ALKB7_HUMAN :
  • Belongs to the alkB family.
Family:
  • Belongs to the alkB family.
genes like me logo Genes that share domains with ALKBH7: view

Function for ALKBH7 Gene

Molecular function for ALKBH7 Gene

UniProtKB/Swiss-Prot Function:
May function as protein hydroxylase; can catalyze auto-hydroxylation at Leu-110 (in vitro), but this activity may be due to the absence of the true substrate (PubMed:25122757). Required to induce programmed necrosis in response to DNA damage caused by cytotoxic alkylating agents. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death (PubMed:23666923). ALKBH7-mediated necrosis is probably required to prevent the accumulation of cells with DNA damage (PubMed:23666923). Does not display DNA demethylase activity (PubMed:23666923). Involved in fatty acid metabolism (By similarity).

Enzyme Numbers (IUBMB) for ALKBH7 Gene

genes like me logo Genes that share phenotypes with ALKBH7: view

Animal Model Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ALKBH7 Gene

Localization for ALKBH7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ALKBH7 Gene

Mitochondrion matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ALKBH7 Gene COMPARTMENTS Subcellular localization image for ALKBH7 gene
Compartment Confidence
mitochondrion 5
cytosol 1
extracellular 1
nucleus 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for ALKBH7 Gene

Pathways & Interactions for ALKBH7 Gene

SuperPathways for ALKBH7 Gene

No Data Available

Interacting Proteins for ALKBH7 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000245812%0d%0a9606.ENSP00000362649%0d%0a
Selected Interacting proteins: ENSP00000245812 Q9BT30-ALKB7_HUMAN for ALKBH7 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for ALKBH7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006974 cellular response to DNA damage stimulus IDA 23666923
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with ALKBH7: view

No data available for Pathways by source and SIGNOR curated interactions for ALKBH7 Gene

Drugs & Compounds for ALKBH7 Gene

No Compound Related Data Available

Transcripts for ALKBH7 Gene

Unigene Clusters for ALKBH7 Gene

AlkB, alkylation repair homolog 7 (E. coli):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ALKBH7 Gene

No ASD Table

Relevant External Links for ALKBH7 Gene

GeneLoc Exon Structure for
ALKBH7
ECgene alternative splicing isoforms for
ALKBH7

Expression for ALKBH7 Gene

mRNA expression in normal human tissues for ALKBH7 Gene

mRNA differential expression in normal tissues according to GTEx for ALKBH7 Gene

This gene is overexpressed in Testis (x7.9).

Protein differential expression in normal tissues from HIPED for ALKBH7 Gene

This gene is overexpressed in Heart (18.4), Urine (10.4), and Testis (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for ALKBH7 Gene



SOURCE GeneReport for Unigene cluster for ALKBH7 Gene Hs.111099

mRNA Expression by UniProt/SwissProt for ALKBH7 Gene

Q9BT30-ALKB7_HUMAN
Tissue specificity: Widely expressed, with highest expression in pancreas, followed by spleen, prostate, ovary and placenta.
genes like me logo Genes that share expression patterns with ALKBH7: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein tissue co-expression partners for ALKBH7 Gene

Orthologs for ALKBH7 Gene

This gene was present in the common ancestor of animals.

Orthologs for ALKBH7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ALKBH7 35
  • 99.7 (n)
  • 100 (a)
ALKBH7 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ALKBH7 36
  • 93 (a)
OneToOne
ALKBH7 35
  • 88.99 (n)
  • 92.76 (a)
dog
(Canis familiaris)
Mammalia ALKBH7 35
  • 91.25 (n)
  • 93.67 (a)
ALKBH7 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Alkbh7 16
Alkbh7 36
  • 82 (a)
OneToOne
Alkbh7 35
  • 80.54 (n)
  • 81.9 (a)
rat
(Rattus norvegicus)
Mammalia Alkbh7 35
  • 79.94 (n)
  • 82.35 (a)
lizard
(Anolis carolinensis)
Reptilia ALKBH7 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia alkbh7 35
  • 57.07 (n)
  • 57.58 (a)
Str.17266 35
zebrafish
(Danio rerio)
Actinopterygii alkbh7 36
  • 47 (a)
OneToOne
alkbh7 35
  • 57.02 (n)
  • 57.37 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000760 35
  • 61.04 (n)
  • 56.02 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14130 36
  • 37 (a)
OneToOne
CG14130 35
  • 59.28 (n)
  • 53.89 (a)
worm
(Caenorhabditis elegans)
Secernentea CELE_Y46G5A.35 35
  • 49.16 (n)
  • 43.58 (a)
Y46G5A.35 36
  • 37 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8958 36
  • 37 (a)
OneToOne
Species with no ortholog for ALKBH7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ALKBH7 Gene

ENSEMBL:
Gene Tree for ALKBH7 (if available)
TreeFam:
Gene Tree for ALKBH7 (if available)

Paralogs for ALKBH7 Gene

No data available for Paralogs for ALKBH7 Gene

Variants for ALKBH7 Gene

Sequence variations from dbSNP and Humsavar for ALKBH7 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_048224 -
rs8105917 -- 6,371,014(+) agagg(A/G)agaAA upstream-variant-2KB
rs56944804 -- 6,370,687(+) GTGGA(C/T)CCAGA upstream-variant-2KB
rs112376672 -- 6,374,199(+) TCTGT(G/T)CAGGC intron-variant
rs78831674 -- 6,371,325(+) AAAAA(A/C)AAACC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ALKBH7 Gene

Variant ID Type Subtype PubMed ID
nsv910911 CNV Loss 21882294
dgv3698n71 CNV Loss 21882294
nsv910916 CNV Loss 21882294
dgv3699n71 CNV Loss 21882294
dgv3700n71 CNV Loss 21882294

Variation tolerance for ALKBH7 Gene

Residual Variation Intolerance Score: 60.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.99; 49.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ALKBH7 Gene

HapMap Linkage Disequilibrium report
ALKBH7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ALKBH7 Gene

Disorders for ALKBH7 Gene

Relevant External Links for ALKBH7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ALKBH7

No disorders were found for ALKBH7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ALKBH7 Gene

Publications for ALKBH7 Gene

  1. Human ALKBH7 is required for alkylation and oxidation-induced programmed necrosis. (PMID: 23666923) Fu D. … Samson L.D. (Genes Dev. 2013) 2 3 4 67
  2. The atomic-resolution structure of human Alkb homolog 7 (ALKBH7), a key protein for programmed necrosis and fat metabolism. (PMID: 25122757) Wang G. … Chen Z. (J. Biol. Chem. 2014) 3
  3. Identification of proteins associated with ligand-activated estrogen receptor I+ in human breast cancer cell nuclei by tandem affinity purification and nano LC-MS/MS. (PMID: 21182205) Tarallo R. … Weisz A. (Proteomics 2011) 3
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  5. A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene. (PMID: 19490893) Luo J. … Elledge S.J. (Cell 2009) 3

Products for ALKBH7 Gene

Sources for ALKBH7 Gene

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