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Aliases for ALKBH7 Gene

Aliases for ALKBH7 Gene

  • AlkB, Alkylation Repair Homolog 7 (E. Coli) 2 3
  • ABH7 3 4 6
  • Spermatogenesis Cell Proliferation-Related Protein 3 4
  • Alkylated DNA Repair Protein AlkB Homolog 7 3 4
  • Spermatogenesis-Associated Protein 11 3 4
  • Spermatogenesis Associated 11 2 3
  • SPATA11 3 4
  • Alpha-Ketoglutarate-Dependent Dioxygenase AlkB Homolog 7, Mitochondrial 3
  • Probable Alpha-Ketoglutarate-Dependent Dioxygenase ABH7 3
  • Spermatogenesis Cell Proliferation Related Protein 3
  • EC 1.14.11.- 4
  • UNQ6002 3

External Ids for ALKBH7 Gene

Previous HGNC Symbols for ALKBH7 Gene

  • SPATA11

Previous GeneCards Identifiers for ALKBH7 Gene

  • GC19P006324
  • GC19P006132

Summaries for ALKBH7 Gene

GeneCards Summary for ALKBH7 Gene

ALKBH7 (AlkB, Alkylation Repair Homolog 7 (E. Coli)) is a Protein Coding gene. GO annotations related to this gene include dioxygenase activity.

UniProtKB/Swiss-Prot for ALKBH7 Gene

  • May function as protein hydroxylase; can catalyze auto-hydroxylation at Leu-110 (in vitro), but this activity may be due to the absence of the true substrate (PubMed:25122757). Required to induce programmed necrosis in response to DNA damage caused by cytotoxic alkylating agents. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death (PubMed:23666923). ALKBH7-mediated necrosis is probably required to prevent the accumulation of cells with DNA damage (PubMed:23666923). Does not display DNA demethylase activity (PubMed:23666923). Involved in fatty acid metabolism (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ALKBH7 Gene

Genomics for ALKBH7 Gene

Regulatory Elements for ALKBH7 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ALKBH7 Gene

Start:
6,372,433 bp from pter
End:
6,375,251 bp from pter
Size:
2,819 bases
Orientation:
Plus strand

Genomic View for ALKBH7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ALKBH7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ALKBH7 Gene

Proteins for ALKBH7 Gene

  • Protein details for ALKBH7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BT30-ALKB7_HUMAN
    Recommended name:
    Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial
    Protein Accession:
    Q9BT30
    Secondary Accessions:
    • B2R4U9
    • Q53FF3

    Protein attributes for ALKBH7 Gene

    Size:
    221 amino acids
    Molecular mass:
    24516 Da
    Cofactor:
    Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Note=Binds 1 Fe(2+) ion per subunit.;
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for ALKBH7 Gene

neXtProt entry for ALKBH7 Gene

Proteomics data for ALKBH7 Gene at MOPED

Post-translational modifications for ALKBH7 Gene

No Post-translational modifications

Other Protein References for ALKBH7 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ALKBH7 (ALKBH7)

No data available for DME Specific Peptides for ALKBH7 Gene

Domains for ALKBH7 Gene

Gene Families for ALKBH7 Gene

HGNC:
  • ALKB :Alkylation repair homologs

Protein Domains for ALKBH7 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ALKBH7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BT30

UniProtKB/Swiss-Prot:

ALKB7_HUMAN :
  • Q9BT30
Family:
  • Belongs to the alkB family.
genes like me logo Genes that share domains with ALKBH7: view

Function for ALKBH7 Gene

Molecular function for ALKBH7 Gene

UniProtKB/Swiss-Prot Function: May function as protein hydroxylase; can catalyze auto-hydroxylation at Leu-110 (in vitro), but this activity may be due to the absence of the true substrate (PubMed:25122757). Required to induce programmed necrosis in response to DNA damage caused by cytotoxic alkylating agents. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death (PubMed:23666923). ALKBH7-mediated necrosis is probably required to prevent the accumulation of cells with DNA damage (PubMed:23666923). Does not display DNA demethylase activity (PubMed:23666923). Involved in fatty acid metabolism (By similarity).

Enzyme Numbers (IUBMB) for ALKBH7 Gene

Gene Ontology (GO) - Molecular Function for ALKBH7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046872 metal ion binding IEA --
GO:0051213 dioxygenase activity IEA --
genes like me logo Genes that share ontologies with ALKBH7: view

Phenotypes for ALKBH7 Gene

genes like me logo Genes that share phenotypes with ALKBH7: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ALKBH7

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ALKBH7 Gene

Localization for ALKBH7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ALKBH7 Gene

Mitochondrion matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ALKBH7 Gene COMPARTMENTS Subcellular localization image for ALKBH7 gene
Compartment Confidence
nucleus 5
extracellular 3
mitochondrion 2
cytosol 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ALKBH7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005759 mitochondrial matrix IDA 23666923
genes like me logo Genes that share ontologies with ALKBH7: view

Pathways for ALKBH7 Gene

SuperPathways for ALKBH7 Gene

No Data Available

Interacting Proteins for ALKBH7 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000245812%0d%0a9606.ENSP00000362649%0d%0a
Selected Interacting proteins: ENSP00000245812 Q9BT30-ALKB7_HUMAN for ALKBH7 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for ALKBH7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006631 fatty acid metabolic process ISS --
GO:0006974 cellular response to DNA damage stimulus IDA 23666923
GO:0010883 regulation of lipid storage ISS --
GO:0055114 oxidation-reduction process IEA --
GO:1902445 regulation of mitochondrial membrane permeability involved in programmed necrotic cell death IMP 23666923
genes like me logo Genes that share ontologies with ALKBH7: view

No data available for Pathways by source for ALKBH7 Gene

Transcripts for ALKBH7 Gene

mRNA/cDNA for ALKBH7 Gene

Unigene Clusters for ALKBH7 Gene

AlkB, alkylation repair homolog 7 (E. coli):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ALKBH7

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ALKBH7 Gene

No ASD Table

Relevant External Links for ALKBH7 Gene

GeneLoc Exon Structure for
ALKBH7
ECgene alternative splicing isoforms for
ALKBH7

Expression for ALKBH7 Gene

mRNA expression in normal human tissues for ALKBH7 Gene

mRNA differential expression in normal tissues according to GTEx for ALKBH7 Gene

This gene is overexpressed in Testis (7.9).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for ALKBH7 Gene

SOURCE GeneReport for Unigene cluster for ALKBH7 Gene Hs.111099

mRNA Expression by UniProt/SwissProt for ALKBH7 Gene

Q9BT30-ALKB7_HUMAN
Tissue specificity: Widely expressed, with highest expression in pancreas, followed by spleen, prostate, ovary and placenta.
genes like me logo Genes that share expressions with ALKBH7: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for ALKBH7 Gene

Orthologs for ALKBH7 Gene

This gene was present in the common ancestor of animals.

Orthologs for ALKBH7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ALKBH7 35
  • 99.7 (n)
  • 100 (a)
ALKBH7 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ALKBH7 35
  • 88.99 (n)
  • 92.76 (a)
ALKBH7 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ALKBH7 35
  • 91.25 (n)
  • 93.67 (a)
ALKBH7 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Alkbh7 35
  • 80.54 (n)
  • 81.9 (a)
Alkbh7 16
Alkbh7 36
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Alkbh7 35
  • 79.94 (n)
  • 82.35 (a)
lizard
(Anolis carolinensis)
Reptilia ALKBH7 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia alkbh7 35
  • 57.07 (n)
  • 57.58 (a)
Str.17266 35
zebrafish
(Danio rerio)
Actinopterygii alkbh7 35
  • 57.02 (n)
  • 57.37 (a)
alkbh7 36
  • 47 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000760 35
  • 61.04 (n)
  • 56.02 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14130 35
  • 59.28 (n)
  • 53.89 (a)
CG14130 36
  • 37 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea CELE_Y46G5A.35 35
  • 49.16 (n)
  • 43.58 (a)
Y46G5A.35 36
  • 37 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8958 36
  • 37 (a)
OneToOne
Species with no ortholog for ALKBH7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ALKBH7 Gene

ENSEMBL:
Gene Tree for ALKBH7 (if available)
TreeFam:
Gene Tree for ALKBH7 (if available)

Paralogs for ALKBH7 Gene

No data available for Paralogs for ALKBH7 Gene

Variants for ALKBH7 Gene

Sequence variations from dbSNP and Humsavar for ALKBH7 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs4603684 -- 6,371,359(+) aaaaa(G/T)tagtt upstream-variant-2KB
rs4807084 -- 6,373,617(+) CAAGC(C/G)CCGGG intron-variant, upstream-variant-2KB
rs7246441 -- 6,372,551(+) TCTAA(A/T)GATTA utr-variant-5-prime, upstream-variant-2KB
rs8105917 -- 6,371,014(+) agagg(A/G)agaAA upstream-variant-2KB
rs8106856 -- 6,371,787(+) tcaaa(G/T)atgat upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ALKBH7 Gene

Variant ID Type Subtype PubMed ID
nsv910911 CNV Loss 21882294
dgv3698n71 CNV Loss 21882294
nsv910916 CNV Loss 21882294
dgv3699n71 CNV Loss 21882294
dgv3700n71 CNV Loss 21882294

Relevant External Links for ALKBH7 Gene

HapMap Linkage Disequilibrium report
ALKBH7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ALKBH7 Gene

Disorders for ALKBH7 Gene

No disorders were found for ALKBH7 Gene.

No data available for UniProtKB/Swiss-Prot for ALKBH7 Gene

Publications for ALKBH7 Gene

  1. Human ALKBH7 is required for alkylation and oxidation-induced programmed necrosis. (PMID: 23666923) Fu D. … Samson L.D. (Genes Dev. 2013) 2 3 4
  2. The atomic-resolution structure of human Alkb homolog 7 (ALKBH7), a key protein for programmed necrosis and fat metabolism. (PMID: 25122757) Wang G. … Chen Z. (J. Biol. Chem. 2014) 3 4
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Identification of proteins associated with ligand-activated estrogen receptor I+ in human breast cancer cell nuclei by tandem affinity purification and nano LC-MS/MS. (PMID: 21182205) Tarallo R. … Weisz A. (Proteomics 2011) 3

Products for ALKBH7 Gene

Sources for ALKBH7 Gene

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