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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ALKBH6 Gene

protein-coding   GIFtS: 37
GCID: GC19M036500

AlkB, Alkylation Repair Homolog 6 (E. Coli)

  Search for ALKBH6
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
AlkB, Alkylation Repair Homolog 6 (E. Coli)1 2     Alpha-Ketoglutarate-Dependent Dioxygenase AlkB Homolog 62
ABH62 3 5     Probable Alpha-Ketoglutarate-Dependent Dioxygenase ABH62
Alkylated DNA Repair Protein AlkB Homolog 62 3     EC 1.14.11.-3
Alkylation Repair Homolog 62     

External Ids:    HGNC: 282431   Entrez Gene: 849642   Ensembl: ENSG000002393827   OMIM: 6133045   UniProtKB: Q3KRA93   

Export aliases for ALKBH6 gene to outside databases

Previous GC identifers: GC19M041192 GC19M033005


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ALKBH6 Gene: 
ALKBH6 (alkB, alkylation repair homolog 6 (E. coli)) is a protein-coding gene. GO annotations related to this gene include oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors and oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen.

UniProtKB/Swiss-Prot: ALKB6_HUMAN, Q3KRA9
Function: Probable dioxygenase that requires molecular oxygen, alpha-ketoglutarate and iron (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ALKBH6 gene promoter:
         E2F-3a   E2F-4   E2F-5   FOXO3   Nkx2-5   E2F-2   FOXO3b   E2F   E2F-1   FOXO3a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidALKBH6 promoter sequence
   Search SABiosciences Chromatin IP Primers for ALKBH6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ALKBH6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.12   Ensembl cytogenetic band:  19q13.12   HGNC cytogenetic band: 19q13.12

ALKBH6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ALKBH6 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M036500:  view genomic region     (about GC identifiers)

Start:
36,500,022 bp from pter      End:
36,505,141 bp from pter
Size:
5,120 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ALKB6_HUMAN, Q3KRA9 (See protein sequence)
Recommended Name: Alpha-ketoglutarate-dependent dioxygenase alkB homolog 6  
Size: 238 amino acids; 26483 Da
Cofactor: Binds 1 Fe(2+) ion per subunit (By similarity)
Subunit: Interacts with METTL21D
Subcellular location: Cytoplasm. Nucleus
Sequence caution: Sequence=AAI05802.1; Type=Erroneous initiation;
Secondary accessions: A5LGM8 A6NLP1 A8MU96
Alternative splicing: 3 isoforms:  Q3KRA9-1   Q3KRA9-2   Q3KRA9-3   

Explore the universe of human proteins at neXtProt for ALKBH6: NX_Q3KRA9

Explore proteomics data for ALKBH6 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q3KRA9

  • ALKBH6 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ALKBH6 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_116267.3  NP_942567.1  

    ENSEMBL proteins: 
     ENSP00000433885   ENSP00000433156   ENSP00000435496   ENSP00000474158   ENSP00000368152  
     ENSP00000436742   ENSP00000252984   ENSP00000436156   ENSP00000433085  

    Human Recombinant Protein Products for ALKBH6: 
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    Cloud-Clone Corp. Proteins for ALKBH6 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--

    ALKBH6 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for ALKBH6


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ALKB: Alkylation repair homologs

    2 InterPro protein domains:
     IPR027450 AlkB-like
     IPR005123 Oxoglu/Fe-dep_dioxygenase

    Graphical View of Domain Structure for InterPro Entry Q3KRA9

    ProtoNet protein and cluster: Q3KRA9

    UniProtKB/Swiss-Prot: ALKB6_HUMAN, Q3KRA9
    Similarity: Belongs to the alkB family
    Similarity: Contains 1 Fe2OG dioxygenase domain


    ALKBH6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ALKB6_HUMAN, Q3KRA9
    Function: Probable dioxygenase that requires molecular oxygen, alpha-ketoglutarate and iron (By similarity)

         Enzyme Number (IUBMB): EC 1.14.11.-1

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0016491oxidoreductase activity ----
    GO:0016702oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ----
    GO:0016706oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors IEA--
    GO:0046872metal ion binding IEA--
         
    ALKBH6 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ALKBH6:
     Decreased nuclei size in G2M 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ALKBH6 
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALKBH6


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ALKBH6

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0055114oxidation-reduction process ----

    ALKBH6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ALKBH6 (ALKB6)

    Search CenterWatch for drugs/clinical trials and news about ALKBH6 / ALKB6

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ALKBH6 gene (2 alternative transcripts): 
    NM_032878.3  NM_198867.1  

    Unigene Cluster for ALKBH6:

    AlkB, alkylation repair homolog 6 (E. coli)
    Hs.71941  [show with all ESTs]
    Unigene Representative Sequence: BM810843
    18/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000495116 ENST00000461668 ENST00000490483 ENST00000490986 ENST00000471323(uc002ocx.1)
    ENST00000486389 ENST00000378875(uc002ocv.1 uc002ocw.1) ENST00000485128
    ENST00000252984 ENST00000497999 ENST00000462793 ENST00000392183(uc010eep.1)
    ENST00000468004 ENST00000481257 ENST00000466196 ENST00000475223 ENST00000592353
    ENST00000590666
    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidALKBH6 3' UTR sequence
    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
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    GenScript: all cDNA clones in your preferred vector (see all 2): ALKBH6 (NM_032878)
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ALKBH6
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ALKBH6

    Additional mRNA sequence: 

    AB273714.1 AK304805.1 AK310130.1 AK310704.1 AK314150.1 AK315894.1 BC105801.1 

    15 DOTS entries:

    DT.97820816  DT.211492  DT.97845273  DT.100720225  DT.97820815  DT.92020294  DT.100792360  DT.100792361 
    DT.121452928  DT.121452926  DT.95375967  DT.101954990  DT.121452913  DT.92419552  DT.97845269 

    24/143 AceView cDNA sequences (see all 143):

    BQ575705 AI201554 AI381843 CA446336 R36772 BU624819 AI869824 BM854129 
    BX366961 BC007601 BM827749 BQ575731 BE743964 AI885505 BM715290 NM_032878 
    CF127787 BM853462 AI241238 BM702065 CR596548 AI364676 BM671031 CA419996 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ALKBH6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCCACGAGG
    ALKBH6 Expression
    About this image


    See ALKBH6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ALKBH6

    SOURCE GeneReport for Unigene cluster: Hs.71941

    UniProtKB/Swiss-Prot: ALKB6_HUMAN, Q3KRA9
    Tissue specificity: Widely expressed, with highest expression in testis and pancreas

        SABiosciences Custom PCR Arrays for ALKBH6
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALKBH6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ALKBH6 gene from 7/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Alkbh61 , 5 alkB, alkylation repair homolog 6 (E. coli)1, 5 86.13(n)1
    91.18(a)1
      7 (17.38 cM)5
    2330651  NM_198027.21  NP_932144.21 
     303087175 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.39752 Xenopus laevis transcribed sequence with weak similarity more 74.95(n)    BM262417.1 
    zebrafish
    (Danio rerio)
    Actinopterygii alkbh61 alkB, alkylation repair homolog 6 (E. coli) 59.59(n)
    57.96(a)
      317736  NM_001005390.1  NP_001005390.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG61441 CG6144 53.76(n)
    50.23(a)
      34443  NM_001038806.2  NP_001033895.1 
    worm
    (Caenorhabditis elegans)
    Secernentea B0564.21 Protein B0564.2 49.87(n)
    43.41(a)
      182043  NM_070121.1  NP_502522.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G203501 oxidoreductase 46.48(n)
    42.66(a)
      827783  NM_001203851.1  NP_001190780.1 
    rice
    (Oryza sativa)
    Liliopsida Os10g04200001 hypothetical protein 50.63(n)
    44.94(a)
      4348649  NM_001071156.1  NP_001064621.1 


    ENSEMBL Gene Tree for ALKBH6 (if available)
    TreeFam Gene Tree for ALKBH6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/60 SNPs in ALKBH6 are shown (see all 60)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1880110691,2
    C--36501747(+) CAGCAA/CAGCTC 2 -- int10--------
    rs1462255681,2
    C--36501774(+) GGACAC/TGGGCC 2 -- int10--------
    rs1401268761,2
    C,F--36501788(+) GGTGTG/TTGGTT 2 -- int11Minor allele frequency- T:0.00EU 1139
    rs758494171,2
    C,F--36501829(+) TTCACG/AAGGAC 4 /L syn12Minor allele frequency- A:0.00WA NA 4666
    rs1924658681,2
    C--36501895(+) CGCTGC/GAGCCA 4 L syn10--------
    rs572415531,2
    C,F--36502021(+) GGCTGG/AAAGCA 2 -- int11Minor allele frequency- A:0.17EA 120
    rs1421711411,2
    --36502023(+) CTGGAA/GGCACC 2 -- int10--------
    rs1178785981,2
    F--36502054(+) TGACCG/ATTTGG 2 -- int11Minor allele frequency- A:0.01EA 120
    rs1839329101,2
    --36502083(+) TCAGAA/GGTTTC 2 -- int10--------
    rs1867708471,2
    --36502084(+) CAGAGG/TTTTCC 2 -- int10--------

    HapMap Linkage Disequilibrium report for ALKBH6 (36500022 - 36505141 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ALKBH6:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1000212CNV Deletion20482838
    nsv911641CNV Loss21882294
    dgv51n68CNV Loss17160897
    nsv911638CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ALKBH6 for disorders           About MalaCards
    OMIM gene information: 613304    OMIM disorders: --


    ALKBH6 for disorders           About GeneDecksing


    Export disorders for ALKBH6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ALKBH6 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ALKBH6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1, 3 Bonaldo M.F.... Soares M.B. (1996)
    2. Lysine methylation of VCP by a member of a novel human protein methyltransferase family. (PubMed id 22948820)2 Kernstock S.... Falnes P.O. (2012)
    3. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
    4. Expression and sub-cellular localization of human ABH family molecules. (PubMed id 17979886)2 Tsujikawa K....Yamamoto H. (2007)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
    7. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Aliases
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      Query String
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    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84964 HGNC: 28243 AceView: MGC15677 Ensembl:ENSG00000239382 euGenes: HUgn84964
    ECgene: ALKBH6 H-InvDB: ALKBH6

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ALKBH6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ALKBH6 gene:
    Search GeneIP for patents involving ALKBH6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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