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Aliases for ALKBH6 Gene

Aliases for ALKBH6 Gene

  • AlkB Homolog 6 2 3 5
  • Alkylated DNA Repair Protein AlkB Homolog 6 3 4
  • ABH6 3 4
  • Probable Alpha-Ketoglutarate-Dependent Dioxygenase ABH6 3
  • AlkB, Alkylation Repair Homolog 6 (E. Coli) 2
  • AlkB, Alkylation Repair Homolog 6 3
  • Alkylation Repair Homolog 6 3
  • EC 1.14.11.- 4

External Ids for ALKBH6 Gene

Previous GeneCards Identifiers for ALKBH6 Gene

  • GC19M041192
  • GC19M036500
  • GC19M033005

Summaries for ALKBH6 Gene

GeneCards Summary for ALKBH6 Gene

ALKBH6 (AlkB Homolog 6) is a Protein Coding gene. GO annotations related to this gene include oxidoreductase activity and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors.

UniProtKB/Swiss-Prot for ALKBH6 Gene

  • Probable dioxygenase that requires molecular oxygen, alpha-ketoglutarate and iron.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ALKBH6 Gene

Genomics for ALKBH6 Gene

Regulatory Elements for ALKBH6 Gene

Enhancers for ALKBH6 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ALKBH6 on UCSC Golden Path with GeneCards custom track

Promoters for ALKBH6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ALKBH6 on UCSC Golden Path with GeneCards custom track

Genomic Location for ALKBH6 Gene

Chromosome:
19
Start:
36,009,116 bp from pter
End:
36,014,243 bp from pter
Size:
5,128 bases
Orientation:
Minus strand

Genomic View for ALKBH6 Gene

Genes around ALKBH6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ALKBH6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ALKBH6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ALKBH6 Gene

Proteins for ALKBH6 Gene

  • Protein details for ALKBH6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3KRA9-ALKB6_HUMAN
    Recommended name:
    Alpha-ketoglutarate-dependent dioxygenase alkB homolog 6
    Protein Accession:
    Q3KRA9
    Secondary Accessions:
    • A5LGM8
    • A6NLP1
    • A8MU96

    Protein attributes for ALKBH6 Gene

    Size:
    238 amino acids
    Molecular mass:
    26483 Da
    Cofactor:
    Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
    Quaternary structure:
    • Interacts with VCPKMT.
    SequenceCaution:
    • Sequence=AAI05802.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ALKBH6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ALKBH6 Gene

Proteomics data for ALKBH6 Gene at MOPED

Post-translational modifications for ALKBH6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ALKBH6 Gene

Domains & Families for ALKBH6 Gene

Gene Families for ALKBH6 Gene

Protein Domains for ALKBH6 Gene

Suggested Antigen Peptide Sequences for ALKBH6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q3KRA9

UniProtKB/Swiss-Prot:

ALKB6_HUMAN :
  • Contains 1 Fe2OG dioxygenase domain.
  • Belongs to the alkB family.
Domain:
  • Contains 1 Fe2OG dioxygenase domain.
Family:
  • Belongs to the alkB family.
genes like me logo Genes that share domains with ALKBH6: view

Function for ALKBH6 Gene

Molecular function for ALKBH6 Gene

UniProtKB/Swiss-Prot Function:
Probable dioxygenase that requires molecular oxygen, alpha-ketoglutarate and iron.

Enzyme Numbers (IUBMB) for ALKBH6 Gene

Gene Ontology (GO) - Molecular Function for ALKBH6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with ALKBH6: view
genes like me logo Genes that share phenotypes with ALKBH6: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ALKBH6

miRNA for ALKBH6 Gene

miRTarBase miRNAs that target ALKBH6

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ALKBH6 Gene

Localization for ALKBH6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ALKBH6 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ALKBH6 Gene COMPARTMENTS Subcellular localization image for ALKBH6 gene
Compartment Confidence
nucleus 3

No data available for Gene Ontology (GO) - Cellular Components for ALKBH6 Gene

Pathways & Interactions for ALKBH6 Gene

SuperPathways for ALKBH6 Gene

No Data Available

Interacting Proteins for ALKBH6 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000368152%0d%0a9606.ENSP00000280758%0d%0a9606.ENSP00000410157%0d%0a
Selected Interacting proteins: ENSP00000368152 for ALKBH6 Gene via STRING

Gene Ontology (GO) - Biological Process for ALKBH6 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ALKBH6 Gene

Drugs & Compounds for ALKBH6 Gene

No Compound Related Data Available

Transcripts for ALKBH6 Gene

Unigene Clusters for ALKBH6 Gene

AlkB, alkylation repair homolog 6 (E. coli):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ALKBH6 Gene

No ASD Table

Relevant External Links for ALKBH6 Gene

GeneLoc Exon Structure for
ALKBH6
ECgene alternative splicing isoforms for
ALKBH6

Expression for ALKBH6 Gene

mRNA expression in normal human tissues for ALKBH6 Gene

SOURCE GeneReport for Unigene cluster for ALKBH6 Gene Hs.71941

mRNA Expression by UniProt/SwissProt for ALKBH6 Gene

Q3KRA9-ALKB6_HUMAN
Tissue specificity: Widely expressed, with highest expression in testis and pancreas.
genes like me logo Genes that share expression patterns with ALKBH6: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for ALKBH6 Gene

Orthologs for ALKBH6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ALKBH6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ALKBH6 35
  • 88.6 (n)
  • 89.85 (a)
ALKBH6 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ALKBH6 35
  • 90.29 (n)
  • 90.04 (a)
ALKBH6 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Alkbh6 35
  • 86.13 (n)
  • 91.18 (a)
Alkbh6 16
Alkbh6 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ALKBH6 35
  • 99.3 (n)
  • 99.16 (a)
ALKBH6 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ALKBH6 36
  • 55 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ALKBH6 36
  • 61 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.3975 35
zebrafish
(Danio rerio)
Actinopterygii alkbh6 35
  • 58.85 (n)
  • 57.52 (a)
alkbh6 36
  • 54 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8694 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003866 35
  • 52.84 (n)
  • 48.85 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6144 35
  • 53.61 (n)
  • 49.31 (a)
CG6144 36
  • 46 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea B0564.2 35
  • 48.37 (n)
  • 41.4 (a)
B0564.2 36
  • 38 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G20350 35
  • 45.57 (n)
  • 42.2 (a)
rice
(Oryza sativa)
Liliopsida Os10g0420000 35
  • 50.63 (n)
  • 44.94 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
OneToOne
Species with no ortholog for ALKBH6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ALKBH6 Gene

ENSEMBL:
Gene Tree for ALKBH6 (if available)
TreeFam:
Gene Tree for ALKBH6 (if available)

Paralogs for ALKBH6 Gene

No data available for Paralogs for ALKBH6 Gene

Variants for ALKBH6 Gene

Sequence variations from dbSNP and Humsavar for ALKBH6 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs140126876 -- 36,010,886(+) GGTGT(G/T)TGGTT intron-variant, nc-transcript-variant
rs8111422 -- 36,011,539(+) ATAGG(C/G)GCCTT intron-variant
rs186770847 -- 36,011,182(+) CAGAG(G/T)TTTCC intron-variant
rs142171141 -- 36,011,121(+) CTGGA(A/G)GCACC intron-variant
rs75849417 -- 36,010,927(+) TTCAC(A/G)AGGAC nc-transcript-variant, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for ALKBH6 Gene

Variant ID Type Subtype PubMed ID
nsv911638 CNV Loss 21882294
dgv51n68 CNV Loss 17160897
nsv911641 CNV Loss 21882294
esv1000212 CNV Deletion 20482838

Variation tolerance for ALKBH6 Gene

Residual Variation Intolerance Score: 74.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.19; 24.01% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ALKBH6 Gene

Disorders for ALKBH6 Gene

Relevant External Links for ALKBH6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ALKBH6

No disorders were found for ALKBH6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ALKBH6 Gene

Publications for ALKBH6 Gene

  1. Lysine methylation of VCP by a member of a novel human protein methyltransferase family. (PMID: 22948820) Kernstock S. … Falnes P.O. (Nat. Commun. 2012) 3 4 67
  2. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 2 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for ALKBH6 Gene

Sources for ALKBH6 Gene

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