Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



ALKBH6 Gene

protein-coding   GIFtS: 40
GCID: GC19M036500

AlkB, Alkylation Repair Homolog 6 (E. Coli)

  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
AlkB, Alkylation Repair Homolog 6 (E. Coli)1 2     Alpha-Ketoglutarate-Dependent Dioxygenase AlkB Homolog 62
ABH62 3 5     Probable Alpha-Ketoglutarate-Dependent Dioxygenase ABH62
Alkylated DNA Repair Protein AlkB Homolog 62 3     EC 1.14.11.-3
Alkylation Repair Homolog 62     

External Ids:    HGNC: 282431   Entrez Gene: 849642   Ensembl: ENSG000002393827   OMIM: 6133045   UniProtKB: Q3KRA93   
ORGUL members:         

Export aliases for ALKBH6 gene to outside databases

Previous GC identifers: GC19M041192 GC19M033005


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for ALKBH6 Gene:
ALKBH6 (alkB, alkylation repair homolog 6 (E. coli)) is a protein-coding gene. GO annotations related to this gene include oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors.

UniProtKB/Swiss-Prot: ALKB6_HUMAN, Q3KRA9
Function: Probable dioxygenase that requires molecular oxygen, alpha-ketoglutarate and iron (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ALKBH6 gene promoter:
         E2F-3a   E2F-4   E2F-5   FOXO3   Nkx2-5   E2F-2   FOXO3b   E2F   E2F-1   FOXO3a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidALKBH6 promoter sequence
   Search Chromatin IP Primers for ALKBH6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ALKBH6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.12   Ensembl cytogenetic band:  19q13.12   HGNC cytogenetic band: 19q13.12

ALKBH6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ALKBH6 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M036500:  view genomic region     (about GC identifiers)

Start:
36,500,022 bp from pter      End:
36,505,141 bp from pter
Size:
5,120 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: ALKB6_HUMAN, Q3KRA9 (See protein sequence)
Recommended Name: Alpha-ketoglutarate-dependent dioxygenase alkB homolog 6  
Size: 238 amino acids; 26483 Da
Cofactor: Binds 1 Fe(2+) ion per subunit (By similarity)
Subunit: Interacts with VCPKMT
Sequence caution: Sequence=AAI05802.1; Type=Erroneous initiation;
Secondary accessions: A5LGM8 A6NLP1 A8MU96
Alternative splicing: 3 isoforms:  Q3KRA9-1   Q3KRA9-2   Q3KRA9-3   

Explore the universe of human proteins at neXtProt for ALKBH6: NX_Q3KRA9

Explore proteomics data for ALKBH6 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ALKBH6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_116267.3  NP_942567.1  

    ENSEMBL proteins: 
     ENSP00000433885   ENSP00000433156   ENSP00000435496   ENSP00000474158   ENSP00000368152  
     ENSP00000436742   ENSP00000252984   ENSP00000436156   ENSP00000433085  

    ALKBH6 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for ALKBH6
    OriGene Protein Over-expression Lysate for ALKBH6
    OriGene MassSpec for ALKBH6
    OriGene Custom Protein Services for ALKBH6
    GenScript Custom Purified and Recombinant Proteins Services for ALKBH6
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ALKBH6

     
    Search eBioscience for Proteins for ALKBH6 

     
    antibodies-online proteins for ALKBH6 (2 products) 

     
    antibodies-online peptides for ALKBH6

    ALKBH6 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for ALKBH6
    Abcam antibodies for ALKBH6
    Cloud-Clone Corp. Antibodies for ALKBH6
    Search ThermoFisher Antibodies for ALKBH6
    antibodies-online antibodies for ALKBH6 (8 products) 

    ALKBH6 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ALKBH6
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ALKBH6
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ALKBH6
    Cloud-Clone Corp. CLIAs for ALKBH6
    Search eBioscience for ELISAs for ALKBH6 
    antibodies-online kits for ALKBH6 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    ALKB: Alkylation repair homologs

    2 InterPro protein domains:
     IPR027450 AlkB-like
     IPR005123 Oxoglu/Fe-dep_dioxygenase

    Graphical View of Domain Structure for InterPro Entry Q3KRA9

    ProtoNet protein and cluster: Q3KRA9

    UniProtKB/Swiss-Prot: ALKB6_HUMAN, Q3KRA9
    Similarity: Belongs to the alkB family
    Similarity: Contains 1 Fe2OG dioxygenase domain


    Find genes that share domains with ALKBH6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ALKB6_HUMAN, Q3KRA9
    Function: Probable dioxygenase that requires molecular oxygen, alpha-ketoglutarate and iron (By similarity)

         Enzyme Number (IUBMB): EC 1.14.11.-1

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0016491oxidoreductase activity ----
    GO:0016706oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ALKBH6           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ALKBH6:
     Decreased nuclei size in G2M 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ALKBH6

    miRNA
    Products:
        
    miRTarBase miRNAs that target ALKBH6:
    hsa-mir-320a (MIRT044584)

    Block miRNA regulation of human, mouse, rat ALKBH6 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate ALKBH6
    SwitchGear 3'UTR luciferase reporter plasmidALKBH6 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ALKBH6
    Predesigned siRNA for gene silencing in human, mouse, rat ALKBH6

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ALKBH6

    Clone
    Products:
         
    OriGene clones in human, mouse for ALKBH6 (see all 13)
    OriGene ORF clones in mouse, rat for ALKBH6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ALKBH6 (NM_032878)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ALKBH6
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ALKBH6

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ALKBH6
    Browse ESI BIO Cell Lines and PureStem Progenitors for ALKBH6 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALKBH6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    ALKB6_HUMAN, Q3KRA9: Cytoplasm. Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with ALKBH6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ALKBH6
    Interactions:

        Search GeneGlobe Interaction Network for ALKBH6

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0055114oxidation-reduction process ----

    Find genes that share ontologies with ALKBH6           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ALKBH6 (ALKB6)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for ALKBH6 gene (2 alternative transcripts): 
    NM_032878.3  NM_198867.1  

    Unigene Cluster for ALKBH6:

    AlkB, alkylation repair homolog 6 (E. coli)
    Hs.71941  [show with all ESTs]
    Unigene Representative Sequence: BM810843
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000495116 ENST00000461668 ENST00000490483 ENST00000490986 ENST00000471323(uc002ocx.1)
    ENST00000486389 ENST00000378875(uc002ocv.1 uc002ocw.1) ENST00000485128
    ENST00000252984 ENST00000497999 ENST00000462793 ENST00000392183(uc010eep.1)
    ENST00000468004 ENST00000481257 ENST00000466196 ENST00000475223 ENST00000592353
    ENST00000590666
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ALKBH6 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate ALKBH6
    SwitchGear 3'UTR luciferase reporter plasmidALKBH6 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ALKBH6
    Predesigned siRNA for gene silencing in human, mouse, rat ALKBH6
    Clone
    Products:
         
    OriGene clones in human, mouse for ALKBH6 (see all 13)
    OriGene ORF clones in mouse, rat for ALKBH6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ALKBH6 (NM_032878)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ALKBH6
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ALKBH6
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ALKBH6
    OriGene qSTAR qPCR primer pairs in human, mouse for ALKBH6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ALKBH6
      QuantiTect SYBR Green Assays in human, mouse, rat ALKBH6
      QuantiFast Probe-based Assays in human, mouse, rat ALKBH6

    Additional mRNA sequence: 

    AB273714.1 AK304805.1 AK310130.1 AK310704.1 AK314150.1 AK315894.1 BC105801.1 

    15 DOTS entries:

    DT.97820816  DT.211492  DT.97845273  DT.100720225  DT.97820815  DT.92020294  DT.100792360  DT.100792361 
    DT.121452928  DT.121452926  DT.95375967  DT.101954990  DT.121452913  DT.92419552  DT.97845269 

    Selected AceView cDNA sequences (see all 143):

    BI915833 CR596548 NM_198867 BM853462 AI499711 BM984807 AU279726 NM_032878 
    BE743964 AW207101 BM671031 CR604192 CB105298 AI537275 BC007601 AI381843 
    BU624819 AI918413 AI885505 AI364676 AW189500 CA419996 BQ575705 AI201554 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    ALKBH6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCCACGAGG
    ALKBH6 Expression
    About this image

    ALKBH6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ALKBH6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.71941

    UniProtKB/Swiss-Prot: ALKB6_HUMAN, Q3KRA9
    Tissue specificity: Widely expressed, with highest expression in testis and pancreas

        Custom PCR Arrays for ALKBH6
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for ALKBH6
    OriGene qSTAR qPCR primer pairs in human, mouse for ALKBH6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ALKBH6
    QuantiTect SYBR Green Assays in human, mouse, rat ALKBH6
    QuantiFast Probe-based Assays in human, mouse, rat ALKBH6
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALKBH6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ALKBH6 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Alkbh61 , 5 alkB, alkylation repair homolog 6 (E. coli)1, 5 86.13(n)1
    91.18(a)1
      7 (17.38 cM)5
    2330651  NM_198027.21  NP_932144.21 
     303087175 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.39752 Xenopus laevis transcribed sequence with weak similarity more 74.95(n)    BM262417.1 
    zebrafish
    (Danio rerio)
    Actinopterygii alkbh61 alkB, alkylation repair homolog 6 (E. coli) 58.85(n)
    57.52(a)
      317736  NM_001005390.1  NP_001005390.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG61441 CG6144 53.61(n)
    49.31(a)
      34443  NM_135570.5  NP_609414.3 
    worm
    (Caenorhabditis elegans)
    Secernentea B0564.21 B0564.2 48.37(n)
    41.4(a)
      182043  NM_070121.2  NP_502522.2 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G203501 AT4G20350 45.57(n)
    42.2(a)
      827783  NM_001203851.1  NP_001190780.1 
    rice
    (Oryza sativa)
    Liliopsida Os10g04200001 Os10g0420000 50.63(n)
    44.94(a)
      4348649  NM_001071156.1  NP_001064621.1 


    ENSEMBL Gene Tree for ALKBH6 (if available)
    TreeFam Gene Tree for ALKBH6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for ALKBH6 (see all 60)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1880110691,2
    C--36501747(+) CAGCAA/CAGCTC 2 -- int10--------
    rs1462255681,2
    C--36501774(+) GGACAC/TGGGCC 2 -- int10--------
    rs1401268761,2
    C,F--36501788(+) GGTGTG/TTGGTT 2 -- int11Minor allele frequency- T:0.00EU 1139
    rs758494171,2
    C,F--36501829(+) TTCACG/AAGGAC 4 /L syn12Minor allele frequency- A:0.00WA NA 4666
    rs1924658681,2
    C--36501895(+) CGCTGC/GAGCCA 4 L syn10--------
    rs572415531,2
    C,F--36502021(+) GGCTGG/AAAGCA 2 -- int11Minor allele frequency- A:0.17EA 120
    rs1421711411,2
    --36502023(+) CTGGAA/GGCACC 2 -- int10--------
    rs1178785981,2
    F--36502054(+) TGACCG/ATTTGG 2 -- int11Minor allele frequency- A:0.01EA 120
    rs1839329101,2
    --36502083(+) TCAGAA/GGTTTC 2 -- int10--------
    rs1867708471,2
    --36502084(+) CAGAGG/TTTTCC 2 -- int10--------

    HapMap Linkage Disequilibrium report for ALKBH6 (36500022 - 36505141 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ALKBH6:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1000212CNV Deletion20482838
    nsv911641CNV Loss21882294
    dgv51n68CNV Loss17160897
    nsv911638CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ALKBH6
    DNA2.0 Custom Variant and Variant Library Synthesis for ALKBH6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 613304    OMIM disorders: --


    Find genes that share disorders with ALKBH6           About GenesLikeMe


    Export disorders for ALKBH6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for ALKBH6 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ALKBH6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1, 3 Bonaldo M.F.... Soares M.B. (Genome Res. 1996)
    2. Lysine methylation of VCP by a member of a novel human protein methyltransferase family. (PubMed id 22948820)2 Kernstock S.... Falnes P.O. (Nat. Commun. 2012)
    3. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)
    4. Expression and sub-cellular localization of human ABH family molecules. (PubMed id 17979886)2 Tsujikawa K.... Yamamoto H. (J. Cell. Mol. Med. 2007)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (Nature 2004)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 84964 HGNC: 28243 AceView: MGC15677 Ensembl:ENSG00000239382 euGenes: HUgn84964
    ECgene: ALKBH6 H-InvDB: ALKBH6

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for ALKBH6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for ALKBH6 gene:
    Search GeneIP for patents involving ALKBH6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for ALKBH6  
     OriGene qPCR primer pairs and template standards for ALKBH6   OriGene Protein Over-expression Lysate for ALKBH6  
     OriGene MassSpec for ALKBH6   OriGene clones in human, mouse for ALKBH6  
     OriGene qSTAR qPCR primer pairs in human, mouse for ALKBH6   OriGene Purified Protein for ALKBH6  
     OriGene ORF clones in mouse, rat for ALKBH6   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ALKBH6   OriGene Custom Protein Services for ALKBH6  

     
     
     Block miRNA regulation of human, mouse, rat ALKBH6 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing ALKBH6
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ALKBH6 Predesigned siRNA for gene silencing in human, mouse, rat ALKBH6
     QuantiFast Probe-based Assays in human, mouse, rat ALKBH6 QuantiTect SYBR Green Assays in human, mouse, rat ALKBH6
     Custom PCR Arrays for ALKBH6 Search Chromatin IP Primers for ALKBH6
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ALKBH6  Search GeneGlobe Interaction Network for ALKBH6
     Regulatory tfbs in ALKBH6 promoter
     GenScript Custom Purified and Recombinant Proteins Services for ALKBH6 GenScript cDNA clones with any tag delivered in your preferred vector for ALKBH6
     GenScript Custom Assay Services for ALKBH6 GenScript Custom overexpressing Cell Line Services for ALKBH6
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for ALKBH6 (ALKB6)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Biologicals
     Novus Tissue Slides
     Antibodies for ALKBH6
     See all of Abcam's Antibodies, Kits and Proteins for ALKBH6
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for ALKBH6
     Antibodies for ALKBH6
     ELISAs for ALKBH6
     CLIAs for ALKBH6



     Browse ESI BIO Cell Lines and PureStem Progenitors for ALKBH6
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALKBH6
     SwitchGear 3'UTR luciferase reporter plasmids for ALKBH6
     SwitchGear Promoter luciferase reporter plasmids for ALKBH6
     Search ThermoFisher Antibodies for ALKBH6
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ALKBH6
     Browse compounds at ApexBio
     Search Addgene for plasmids for ALKBH6
      Search eBioscience for proteins for ALKBH6
      Search eBioscience for elisas for ALKBH6
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for ALKBH6
     antibodies-online antibodies for ALKBH6 (8 products)
     antibodies-online kits for ALKBH6 (4 products)
     antibodies-online peptides for ALKBH6
     antibodies-online proteins for ALKBH6 (2 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ALKBH6 gene at Home site.
    Version: 3.12.250 16 Nov 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4