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Aliases for ALKBH6 Gene

Aliases for ALKBH6 Gene

  • AlkB Homolog 6 2 3 5
  • Alkylated DNA Repair Protein AlkB Homolog 6 3 4
  • ABH6 3 4
  • Alpha-Ketoglutarate-Dependent Dioxygenase AlkB Homolog 6 3
  • Probable Alpha-Ketoglutarate-Dependent Dioxygenase ABH6 3
  • AlkB, Alkylation Repair Homolog 6 (E. Coli) 2
  • AlkB, Alkylation Repair Homolog 6 3
  • Alkylation Repair Homolog 6 3
  • EC 1.14.11.- 4

External Ids for ALKBH6 Gene

Previous GeneCards Identifiers for ALKBH6 Gene

  • GC19M041192
  • GC19M036500
  • GC19M033005

Summaries for ALKBH6 Gene

GeneCards Summary for ALKBH6 Gene

ALKBH6 (AlkB Homolog 6) is a Protein Coding gene. Diseases associated with ALKBH6 include Rhabdomyosarcoma 2, Alveolar. GO annotations related to this gene include oxidoreductase activity and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors.

UniProtKB/Swiss-Prot for ALKBH6 Gene

  • Probable dioxygenase that requires molecular oxygen, alpha-ketoglutarate and iron.

Additional gene information for ALKBH6 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ALKBH6 Gene

Genomics for ALKBH6 Gene

Regulatory Elements for ALKBH6 Gene

Enhancers for ALKBH6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H035701 2 FANTOM5 Ensembl ENCODE dbSUPER 10 +311.6 311643 1.6 HDGF PKNOX1 ARID4B SIN3A FEZF1 ZNF2 ZNF416 ZNF143 ZNF548 FOS ZNF567 PROSER3 TMEM147-AS1 ZNF599 HAUS5 U2AF1L4 KMT2B ENSG00000267049 ZNF792 ZNF146
GH19H035208 2 FANTOM5 Ensembl ENCODE dbSUPER 9.9 +801.8 801819 7.1 PKNOX1 FOXA2 FEZF1 ZNF2 SP3 SP5 JUNB ZNF592 MEF2D SREBF1 ZNF599 TMEM147-AS1 KIAA0355 HAUS5 PROSER3 RBM42 MAG ZNF792 SDHAF1 USF2
GH19H035710 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10 +299.1 299051 10 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF529 ZFP82 U2AF1L4 ZNF567 TMEM147-AS1 RBM42 LINC00665 ZNF461 PROSER3 ZNF529-AS1
GH19H035641 1.7 FANTOM5 ENCODE dbSUPER 10 +370.7 370713 4.6 HDGF PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 KMT2B RBM42 TMEM147-AS1 PROSER3 ZNF792 HAUS5 ZNF529 ZNF566 ZNF181 ENSG00000267049
GH19H035946 1.6 FANTOM5 Ensembl ENCODE 10.1 +66.9 66851 0.8 HDGF ARNT ARID4B SIN3A FEZF1 ZNF2 ZNF302 ZNF416 ZNF143 ZNF548 ZNF567 ZNF345 ZNF850 TMEM147-AS1 PROSER3 HAUS5 ZNF790 ZNF529 KMT2B ZNF790-AS1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ALKBH6 on UCSC Golden Path with GeneCards custom track

Promoters for ALKBH6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000109101 43 1201 HDGF PKNOX1 ARID4B SIN3A FEZF1 DMAP1 YBX1 ZNF2 YY1 ZNF416

Genomic Locations for ALKBH6 Gene

Genomic Locations for ALKBH6 Gene
chr19:36,009,116-36,014,243
(GRCh38/hg38)
Size:
5,128 bases
Orientation:
Minus strand
chr19:36,500,022-36,505,141
(GRCh37/hg19)

Genomic View for ALKBH6 Gene

Genes around ALKBH6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ALKBH6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ALKBH6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ALKBH6 Gene

Proteins for ALKBH6 Gene

  • Protein details for ALKBH6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3KRA9-ALKB6_HUMAN
    Recommended name:
    Alpha-ketoglutarate-dependent dioxygenase alkB homolog 6
    Protein Accession:
    Q3KRA9
    Secondary Accessions:
    • A5LGM8
    • A6NLP1
    • A8MU96

    Protein attributes for ALKBH6 Gene

    Size:
    238 amino acids
    Molecular mass:
    26483 Da
    Cofactor:
    Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
    Quaternary structure:
    • Interacts with VCPKMT.
    SequenceCaution:
    • Sequence=AAI05802.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ALKBH6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ALKBH6 Gene

Post-translational modifications for ALKBH6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ALKBH6 Gene

Domains & Families for ALKBH6 Gene

Gene Families for ALKBH6 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Protein Domains for ALKBH6 Gene

Suggested Antigen Peptide Sequences for ALKBH6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q3KRA9

UniProtKB/Swiss-Prot:

ALKB6_HUMAN :
  • Belongs to the alkB family.
Family:
  • Belongs to the alkB family.
genes like me logo Genes that share domains with ALKBH6: view

Function for ALKBH6 Gene

Molecular function for ALKBH6 Gene

UniProtKB/Swiss-Prot Function:
Probable dioxygenase that requires molecular oxygen, alpha-ketoglutarate and iron.

Enzyme Numbers (IUBMB) for ALKBH6 Gene

Phenotypes From GWAS Catalog for ALKBH6 Gene

Gene Ontology (GO) - Molecular Function for ALKBH6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22948820
GO:0008198 ferrous iron binding IBA --
GO:0016491 oxidoreductase activity IEA --
GO:0046872 metal ion binding IEA --
GO:0051213 dioxygenase activity IBA --
genes like me logo Genes that share ontologies with ALKBH6: view
genes like me logo Genes that share phenotypes with ALKBH6: view

Animal Model Products

miRNA for ALKBH6 Gene

miRTarBase miRNAs that target ALKBH6

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ALKBH6 Gene

Localization for ALKBH6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ALKBH6 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ALKBH6 gene
Compartment Confidence
nucleus 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Focal adhesion sites (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ALKBH6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005925 focal adhesion IDA --
genes like me logo Genes that share ontologies with ALKBH6: view

Pathways & Interactions for ALKBH6 Gene

SuperPathways for ALKBH6 Gene

No Data Available

Interacting Proteins for ALKBH6 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000368152%0d%0a9606.ENSP00000410157%0d%0a9606.ENSP00000280758%0d%0a
Selected Interacting proteins: Q3KRA9-ALKB6_HUMAN ENSP00000368152 for ALKBH6 Gene via IID STRING

Gene Ontology (GO) - Biological Process for ALKBH6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with ALKBH6: view

No data available for Pathways by source and SIGNOR curated interactions for ALKBH6 Gene

Drugs & Compounds for ALKBH6 Gene

No Compound Related Data Available

Transcripts for ALKBH6 Gene

Unigene Clusters for ALKBH6 Gene

AlkB, alkylation repair homolog 6 (E. coli):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ALKBH6 Gene

No ASD Table

Relevant External Links for ALKBH6 Gene

GeneLoc Exon Structure for
ALKBH6
ECgene alternative splicing isoforms for
ALKBH6

Expression for ALKBH6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ALKBH6 Gene

NURSA nuclear receptor signaling pathways regulating expression of ALKBH6 Gene:

ALKBH6

SOURCE GeneReport for Unigene cluster for ALKBH6 Gene:

Hs.71941

mRNA Expression by UniProt/SwissProt for ALKBH6 Gene:

Q3KRA9-ALKB6_HUMAN
Tissue specificity: Widely expressed, with highest expression in testis and pancreas.

Evidence on tissue expression from TISSUES for ALKBH6 Gene

  • Nervous system(2.3)
genes like me logo Genes that share expression patterns with ALKBH6: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ALKBH6 Gene

Orthologs for ALKBH6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ALKBH6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ALKBH6 33 34
  • 99.3 (n)
dog
(Canis familiaris)
Mammalia ALKBH6 33 34
  • 90.29 (n)
cow
(Bos Taurus)
Mammalia ALKBH6 33 34
  • 88.6 (n)
mouse
(Mus musculus)
Mammalia Alkbh6 33 16 34
  • 86.13 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ALKBH6 34
  • 61 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ALKBH6 34
  • 55 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.3975 33
zebrafish
(Danio rerio)
Actinopterygii alkbh6 33 34
  • 58.85 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8694 33
fruit fly
(Drosophila melanogaster)
Insecta CG6144 33 34
  • 53.61 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003866 33
  • 52.84 (n)
worm
(Caenorhabditis elegans)
Secernentea B0564.2 33 34
  • 48.37 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G20350 33
  • 45.57 (n)
rice
(Oryza sativa)
Liliopsida Os10g0420000 33
  • 50.63 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 40 (a)
OneToOne
Species where no ortholog for ALKBH6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ALKBH6 Gene

ENSEMBL:
Gene Tree for ALKBH6 (if available)
TreeFam:
Gene Tree for ALKBH6 (if available)

Paralogs for ALKBH6 Gene

No data available for Paralogs for ALKBH6 Gene

Variants for ALKBH6 Gene

Sequence variations from dbSNP and Humsavar for ALKBH6 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000613564 -- 36,014,695(+) AGGAG(A/T)CATGC intron-variant, upstream-variant-2KB, utr-variant-3-prime
rs1000737033 -- 36,014,488(+) TGGGT(A/G)GGACG downstream-variant-500B, upstream-variant-2KB
rs1002151520 -- 36,009,655(+) GCAAA(A/G)GCTGA intron-variant, upstream-variant-2KB
rs1002221880 -- 36,009,405(+) CTGCC(A/G)CATTG upstream-variant-2KB, reference, missense, utr-variant-3-prime
rs1002749180 -- 36,011,132(+) CTGAT(C/T)CTCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ALKBH6 Gene

Variant ID Type Subtype PubMed ID
esv1000212 CNV deletion 20482838
dgv51n68 CNV loss 17160897

Variation tolerance for ALKBH6 Gene

Residual Variation Intolerance Score: 74.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.19; 24.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ALKBH6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ALKBH6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ALKBH6 Gene

Disorders for ALKBH6 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ALKBH6 Gene - From: DISEASES

Disorder Aliases PubMed IDs
rhabdomyosarcoma 2, alveolar
  • rhabdomyosarcoma, alveolar
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ALKBH6

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ALKBH6
genes like me logo Genes that share disorders with ALKBH6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ALKBH6 Gene

Publications for ALKBH6 Gene

  1. Lysine methylation of VCP by a member of a novel human protein methyltransferase family. (PMID: 22948820) Kernstock S … Falnes PØ (Nature communications 2012) 3 4 60
  2. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo MF … Soares MB (Genome research 1996) 2 3 60
  3. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PMID: 20068231) Olsen JV … Mann M (Science signaling 2010) 4 60
  4. Expression and sub-cellular localization of human ABH family molecules. (PMID: 17979886) Tsujikawa K … Yamamoto H (Journal of cellular and molecular medicine 2007) 4 60
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 60

Products for ALKBH6 Gene

Sources for ALKBH6 Gene

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