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ALKBH5 Gene

protein-coding   GIFtS: 42
GCID: GC17P018086

AlkB, Alkylation Repair Homolog 5 (E. Coli)

(Previous name: oxoglutarate and iron-dependent oxygenase domain containing)
(Previous symbol: OFOXD1)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
AlkB, Alkylation Repair Homolog 5 (E. Coli)1 2     Alpha-Ketoglutarate-Dependent Dioxygenase AlkB Homolog 52 3
OFOXD11 2 3     OFOXD2
ABH52 3 5     Probable Alpha-Ketoglutarate-Dependent Dioxygenase ABH52
Oxoglutarate And Iron-Dependent Oxygenase Domain Containing1 2     RNA Demethylase ALKBH52
Alkylated DNA Repair Protein AlkB Homolog 52 3     EC 1.14.11.-3

External Ids:    HGNC: 259961   Entrez Gene: 548902   Ensembl: ENSG000000915427   OMIM: 6133035   UniProtKB: Q6P6C23   

Export aliases for ALKBH5 gene to outside databases

Previous GC identifers: GC17P018031 GC17P017840


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ALKBH5 Gene:
ALKBH5 (alkB, alkylation repair homolog 5 (E. coli)) is a protein-coding gene. GO annotations related to this gene include oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors and oxidative RNA demethylase activity.

UniProtKB/Swiss-Prot: ALKB5_HUMAN, Q6P6C2
Function: Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates
N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher
eukaryotes. Requires molecular oxygen, alpha-ketoglutarate and iron. Demethylation of m6A mRNA affects mRNA
processing and export and is required for spermatogenesis




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the ALKBH5 gene promoter:
         Pax-5   HTF   Pax-2   Pax-2a   XBP-1   Tal-1beta   Max   HEN1   ITF-2   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidALKBH5 promoter sequence
   Search Chromatin IP Primers for ALKBH5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ALKBH5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p11.2|17p11.2   Ensembl cytogenetic band:  17p11.2   HGNC cytogenetic band: 17p11.2

ALKBH5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ALKBH5 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P018086:  view genomic region     (about GC identifiers)

Start:
18,086,392 bp from pter      End:
18,113,268 bp from pter
Size:
26,877 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ALKB5_HUMAN, Q6P6C2 (See protein sequence)
Recommended Name: RNA demethylase ALKBH5  
Size: 394 amino acids; 44256 Da
Cofactor: Binds 1 Fe(2+) ion per subunit (By similarity)
Sequence caution: Sequence=BAA91078.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B4DVJ4 D3DXC6 Q9NXD6
Alternative splicing: 3 isoforms:  Q6P6C2-2   Q6P6C2-1   Q6P6C2-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ALKBH5: NX_Q6P6C2

Explore proteomics data for ALKBH5 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys132, Lys147
  • Modification sites at PhosphoSitePlus

  • See ALKBH5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060228.3  
    ENSEMBL proteins: 
     ENSP00000468116   ENSP00000382091  

    ALKBH5 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for ALKBH5

     
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    antibodies-online proteins for ALKBH5 (3 products) 

     
    antibodies-online peptides for ALKBH5

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    antibodies-online antibodies for ALKBH5 (13 products) 

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    antibodies-online kits for ALKBH5 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ALKB: Alkylation repair homologs

    1 InterPro protein domain:
     IPR027450 AlkB-like

    Graphical View of Domain Structure for InterPro Entry Q6P6C2

    ProtoNet protein and cluster: Q6P6C2

    UniProtKB/Swiss-Prot: ALKB5_HUMAN, Q6P6C2
    Similarity: Belongs to the alkB family


    Find genes that share domains with ALKBH5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ALKB5_HUMAN, Q6P6C2
    Function: Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates
    N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher
    eukaryotes. Requires molecular oxygen, alpha-ketoglutarate and iron. Demethylation of m6A mRNA affects mRNA
    processing and export and is required for spermatogenesis
    Induction: By hypoxia, directly activated by HIF1A. Expression is regulated by PRMT7

         Enzyme Number (IUBMB): EC 1.14.11.-1

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016706oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors IDA--
    GO:0035515oxidative RNA demethylase activity IDA--
    GO:0044822poly(A) RNA binding IDA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with ALKBH5           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ALKBH5:
     Increased gamma-H2AX phosphory 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Alkbh5):
     cellular  endocrine/exocrine gland  reproductive system 

    Find genes that share phenotypes with ALKBH5           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Alkbh5tm1.1Klng for ALKBH5

       genOway: Develop your customized and physiologically relevant rodent model for ALKBH5

    miRNA
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    miRTarBase miRNAs that target ALKBH5:
    hsa-mir-96-5p (MIRT048722), hsa-mir-92a-3p (MIRT049251), hsa-mir-615-3p (MIRT039912), hsa-mir-484 (MIRT042009)

    Block miRNA regulation of human, mouse, rat ALKBH5 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ALKBH5 (see all 58):
    hsa-miR-302d hsa-miR-520e hsa-miR-3607-3p hsa-miR-193a-3p hsa-miR-1197 hsa-miR-890 hsa-miR-372 hsa-miR-3122
    SwitchGear 3'UTR luciferase reporter plasmidALKBH5 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ALKBH5

    Gene Editing
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    Browse Sino Biological Human cDNA Clones
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    Addgene plasmids for ALKBH5 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALKBH5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ALKB5_HUMAN, Q6P6C2: Nucleus speckle
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol1
    golgi apparatus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0016607nuclear speck IDA--

    Find genes that share ontologies with ALKBH5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ALKBH5
    Interactions:

        Search GeneGlobe Interaction Network for ALKBH5

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for ALKBH5 (ENSP000003820914) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SIRT5ENSP000003685524STRING: ENSP00000368552
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001666response to hypoxia IDA--
    GO:0006397mRNA processing IMP--
    GO:0006406mRNA export from nucleus IMP--
    GO:0007283spermatogenesis ISS--
    GO:0030154cell differentiation IEA--

    Find genes that share ontologies with ALKBH5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ALKBH5 (ALKB5)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ALKBH5 gene: 
    NM_017758.3  

    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000541285 ENST00000399138(uc010cpw.3) ENST00000490106
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ALKBH5 (see all 58):
    hsa-miR-302d hsa-miR-520e hsa-miR-3607-3p hsa-miR-193a-3p hsa-miR-1197 hsa-miR-890 hsa-miR-372 hsa-miR-3122
    SwitchGear 3'UTR luciferase reporter plasmidALKBH5 3' UTR sequence
    Inhib. RNA
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ALKBH5
      QuantiTect SYBR Green Assays in human, mouse, rat ALKBH5
      QuantiFast Probe-based Assays in human, mouse, rat ALKBH5

    Selected AceView cDNA sequences (see all 398):

    AI478159 AI337415 BF037071 BF726683 AI422312 BM852561 AI085647 BQ675409 
    AW235804 AI675068 AI797503 AI075377 AK000129 AI038248 AW271663 CA390702 
    AI160898 AW338389 AI190682 D81994 AI218162 CA311404 BM424205 BM757740 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ALKBH5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATCCAAGGC
    ALKBH5 Expression
    About this image

    ALKBH5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ALKBH5 Protein Expression

    UniProtKB/Swiss-Prot: ALKB5_HUMAN, Q6P6C2
    Tissue specificity: Widely expressed, with highest expression in lung, followed by testis, pancreas, spleen and
    ovary

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ALKBH5 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Alkbh51 , 5 alkB, alkylation repair homolog 5 (E. coli)1, 5 91.46(n)1
    97.21(a)1
      11 (37.81 cM)5
    2684201  NM_172943.41  NP_766531.21 
     605363815 
    chicken
    (Gallus gallus)
    Aves ALKBH51 alkB, alkylation repair homolog 5 (E. coli) 78.08(n)
    85.71(a)
      770703  XM_001233462.3  XP_001233463.1 
    lizard
    (Anolis carolinensis)
    Reptilia ALKBH56
    alkB, alkylation repair homolog 5 (E. coli)
    82(a)
    1 ↔ 1
    GL343618.1(19987-37398)
    African clawed frog
    (Xenopus laevis)
    Amphibia 480482982   -- 84.87(n)    48048298 
    zebrafish
    (Danio rerio)
    Actinopterygii CK147300.12   -- 78.84(n)    CK147300.1 


    ENSEMBL Gene Tree for ALKBH5 (if available)
    TreeFam Gene Tree for ALKBH5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ALKBH5 (see all 572)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs739808161,2
    C,F--18084876(+) AGCGGC/TTTCTT 1 -- us2k12Minor allele frequency- T:0.10WA 120
    rs1510815931,2
    --18084904(+) GTTGAA/GCCAAA 1 -- us2k10--------
    rs1154223771,2
    F--18084999(+) TGCTCT/CTGAGC 1 -- us2k11Minor allele frequency- C:0.02WA 118
    rs1813497651,2
    --18085182(+) CCTCAC/TTGAAT 1 -- us2k10--------
    rs9973151,2
    C,F,A,H--18085286(-) GCCACT/CGCGCC 1 -- us2k110Minor allele frequency- C:0.14NS EA NA WA CSA 657
    rs1860185791,2
    --18085304(+) TGTAAC/TCCCAG 1 -- us2k10--------
    rs1909419511,2
    --18085469(+) GTGTGA/GGAGGA 1 -- us2k10--------
    rs1398680521,2
    --18085495(+) AGGTCA/GAGATT 1 -- us2k10--------
    rs1168163261,2
    C,F--18085700(+) TACAGG/AATGAG 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1498366601,2
    --18085868(+) TTGGAG/TCCCTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ALKBH5 (18086392 - 18113268 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for ALKBH5:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv510702CNV Loss20534489
    dgv3078n71CNV Loss21882294
    dgv3077n71CNV Loss21882294
    nsv155OTHER Inversion15895083
    nsv499114OTHER Inversion21111241

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ALKBH5
    DNA2.0 Custom Variant and Variant Library Synthesis for ALKBH5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613303    OMIM disorders: --


    Find genes that share disorders with ALKBH5           About GenesLikeMe


    Export disorders for ALKBH5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ALKBH5 gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with ALKBH5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility. (PubMed id 23177736)1, 2 Zheng G.... He C. (Mol. Cell 2013)
    2. Human AlkB homologue 5 is a nuclear 2-oxoglutarate dependent oxygenase and a direct target of hypoxia-inducible factor 1alpha (HIF- 1alpha). (PubMed id 21264265)1, 2 Thalhammer A.... Pollard P.J. (PLoS ONE 2011)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Genes in a refined Smith-Magenis syndrome critical deletion interval on chromosome 17p11.2 and the syntenic region of the mouse. (PubMed id 11997338)1, 3 Bi W....Lupski J.R. (Genome Res. 2002)
    6. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    7. The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition. (PubMed id 24163370)1 Lu L....Zhang L. (J. Biol. Chem. 2013)
    8. Protein arginine methyltransferase 7 regulates cellular response to DNA damage by methylating promoter histones H2A and H4 of the polymerase delta catalytic subunit gene, POLD1. (PubMed id 22761421)2 Karkhanis V.... Sif S. (J. Biol. Chem. 2012)
    9. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (PLoS ONE 2012)
    10. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54890 HGNC: 25996 AceView: FLJ20308 Ensembl:ENSG00000091542 euGenes: HUgn54890
    ECgene: ALKBH5 H-InvDB: ALKBH5

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ALKBH5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ALKBH5 gene:
    Search GeneIP for patents involving ALKBH5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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