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Aliases for ALKBH5 Gene

Aliases for ALKBH5 Gene

  • AlkB Family Member 5, RNA Demethylase 2 3
  • ABH5 3 4 6
  • Oxoglutarate And Iron-Dependent Oxygenase Domain Containing 2 3
  • Alpha-Ketoglutarate-Dependent Dioxygenase AlkB Homolog 5 3 4
  • Alkylated DNA Repair Protein AlkB Homolog 5 3 4
  • OFOXD1 3 4
  • Probable Alpha-Ketoglutarate-Dependent Dioxygenase ABH5 3
  • AlkB, Alkylation Repair Homolog 5 (E. Coli) 2
  • AlkB, Alkylation Repair Homolog 5 3
  • RNA Demethylase ALKBH5 3
  • EC 1.14.11.- 4
  • OFOXD 3

External Ids for ALKBH5 Gene

Previous Symbols for ALKBH5 Gene

  • OFOXD1

Summaries for ALKBH5 Gene

GeneCards Summary for ALKBH5 Gene

ALKBH5 (AlkB Family Member 5, RNA Demethylase) is a Protein Coding gene. GO annotations related to this gene include oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors and oxidative RNA demethylase activity.

UniProtKB/Swiss-Prot for ALKBH5 Gene

  • Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (PubMed:23177736, PubMed:24778178, PubMed:24616105, PubMed:24489119). Can also demethylate N(6)-methyladenosine in single-stranded DNA (in vitro) (PubMed:24616105). Requires molecular oxygen, alpha-ketoglutarate and iron (PubMed:21264265, PubMed:23177736, PubMed:24778178, PubMed:24616105, PubMed:24489119). Demethylation of m6A mRNA affects mRNA processing and export (PubMed:23177736). Required for spermatogenesis (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ALKBH5 Gene

Genomics for ALKBH5 Gene

Genomic Location for ALKBH5 Gene

Start:
18,183,078 bp from pter
End:
18,209,954 bp from pter
Size:
26,877 bases
Orientation:
Plus strand

Genomic View for ALKBH5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ALKBH5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ALKBH5 Gene

Regulatory Elements for ALKBH5 Gene

Proteins for ALKBH5 Gene

  • Protein details for ALKBH5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P6C2-ALKB5_HUMAN
    Recommended name:
    RNA demethylase ALKBH5
    Protein Accession:
    Q6P6C2
    Secondary Accessions:
    • B4DVJ4
    • D3DXC6
    • Q9NXD6

    Protein attributes for ALKBH5 Gene

    Size:
    394 amino acids
    Molecular mass:
    44256 Da
    Cofactor:
    Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Note=Binds 1 Fe(2+) ion per subunit.;
    Quaternary structure:
    • Monomer.
    SequenceCaution:
    • Sequence=BAA91078.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ALKBH5 Gene

    Alternative splice isoforms for ALKBH5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ALKBH5 Gene

Proteomics data for ALKBH5 Gene at MOPED

Post-translational modifications for ALKBH5 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys132 and Lys147

Other Protein References for ALKBH5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ALKBH5 Gene

Domains for ALKBH5 Gene

Gene Families for ALKBH5 Gene

HGNC:
  • ALKB :Alkylation repair homologs

Protein Domains for ALKBH5 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

ALKB5_HUMAN
Family:
  • Belongs to the alkB family.:
    • Q6P6C2
genes like me logo Genes that share domains with ALKBH5: view

Function for ALKBH5 Gene

Molecular function for ALKBH5 Gene

UniProtKB/Swiss-Prot Function: Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (PubMed:23177736, PubMed:24778178, PubMed:24616105, PubMed:24489119). Can also demethylate N(6)-methyladenosine in single-stranded DNA (in vitro) (PubMed:24616105). Requires molecular oxygen, alpha-ketoglutarate and iron (PubMed:21264265, PubMed:23177736, PubMed:24778178, PubMed:24616105, PubMed:24489119). Demethylation of m6A mRNA affects mRNA processing and export (PubMed:23177736). Required for spermatogenesis (By similarity).
UniProtKB/Swiss-Prot Induction: By hypoxia, directly activated by HIF1A. Expression is regulated by PRMT7.

Enzyme Numbers (IUBMB) for ALKBH5 Gene

Gene Ontology (GO) - Molecular Function for ALKBH5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors IDA 21264265
GO:0035515 oxidative RNA demethylase activity IDA 23177736
GO:0044822 poly(A) RNA binding IDA 22658674
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ALKBH5: view

Phenotypes for ALKBH5 Gene

genes like me logo Genes that share phenotypes with ALKBH5: view

Animal Models for ALKBH5 Gene

MGI Knock Outs for ALKBH5:

miRNA for ALKBH5 Gene

No data available for Transcription Factor Targeting and HOMER Transcription for ALKBH5 Gene

Localization for ALKBH5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ALKBH5 Gene

Nucleus speckle.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ALKBH5 Gene COMPARTMENTS Subcellular localization image for ALKBH5 gene
Compartment Confidence
nucleus 5
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ALKBH5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21264265
GO:0016607 nuclear speck IDA 23177736
genes like me logo Genes that share ontologies with ALKBH5: view

Pathways for ALKBH5 Gene

SuperPathways for ALKBH5 Gene

No Data Available

Interacting Proteins for ALKBH5 Gene

Gene Ontology (GO) - Biological Process for ALKBH5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IDA 21264265
GO:0002230 positive regulation of defense response to virus by host IMP 22020285
GO:0006397 mRNA processing IMP 23177736
GO:0006406 mRNA export from nucleus IMP 23177736
GO:0007283 spermatogenesis ISS --
genes like me logo Genes that share ontologies with ALKBH5: view

No data available for Pathways by source for ALKBH5 Gene

Transcripts for ALKBH5 Gene

mRNA/cDNA for ALKBH5 Gene

Unigene Clusters for ALKBH5 Gene

AlkB, alkylation repair homolog 5 (E. coli):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ALKBH5 Gene

No ASD Table

Relevant External Links for ALKBH5 Gene

GeneLoc Exon Structure for
ALKBH5
ECgene alternative splicing isoforms for
ALKBH5

Expression for ALKBH5 Gene

mRNA expression in normal human tissues for ALKBH5 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ALKBH5 Gene

SOURCE GeneReport for Unigene cluster for ALKBH5 Gene Hs.744130

mRNA Expression by UniProt/SwissProt for ALKBH5 Gene

Q6P6C2-ALKB5_HUMAN
Tissue specificity: Widely expressed, with highest expression in lung, followed by testis, pancreas, spleen and ovary.
genes like me logo Genes that share expressions with ALKBH5: view

Orthologs for ALKBH5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ALKBH5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ALKBH5 36
  • 99.83 (n)
  • 99.49 (a)
ALKBH5 37
  • 84 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ALKBH5 36
  • 92.39 (n)
  • 96.95 (a)
ALKBH5 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ALKBH5 36
  • 94.84 (n)
  • 99.49 (a)
ALKBH5 37
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Alkbh5 36
  • 91.46 (n)
  • 97.21 (a)
Alkbh5 16
Alkbh5 37
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ALKBH5 37
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ALKBH5 37
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Alkbh5 36
  • 91.03 (n)
  • 97.72 (a)
chicken
(Gallus gallus)
Aves ALKBH5 36
  • 78.08 (n)
  • 85.71 (a)
ALKBH5 37
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ALKBH5 37
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia alkbh5 36
  • 75.24 (n)
  • 78.53 (a)
zebrafish
(Danio rerio)
Actinopterygii alkbh5 36
  • 71.21 (n)
  • 75.07 (a)
alkbh5 37
  • 74 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10218 37
  • 46 (a)
OneToOne
Species with no ortholog for ALKBH5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ALKBH5 Gene

ENSEMBL:
Gene Tree for ALKBH5 (if available)
TreeFam:
Gene Tree for ALKBH5 (if available)

Paralogs for ALKBH5 Gene

No data available for Paralogs for ALKBH5 Gene

Variants for ALKBH5 Gene

Sequence variations from dbSNP and Humsavar for ALKBH5 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs8400 -- 18,209,531(-) TTTTT(C/T)CTTAT utr-variant-3-prime
rs13284 -- 18,208,816(-) GGGGC(A/G)AGCAG utr-variant-3-prime
rs854803 -- 18,185,916(+) AAAAC(A/C)TCTTA intron-variant
rs997315 -- 18,181,972(-) GCCAC(C/T)GCGCC upstream-variant-2KB
rs1064629 -- 18,183,985(-) GCGCC(A/G)GCAGC utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for ALKBH5 Gene

Variant ID Type Subtype PubMed ID
nsv155 OTHER Inversion 15895083
nsv499114 OTHER Inversion 21111241
dgv3077n71 CNV Loss 21882294
nsv510702 CNV Loss 20534489
dgv3078n71 CNV Loss 21882294

Relevant External Links for ALKBH5 Gene

HapMap Linkage Disequilibrium report
ALKBH5

Disorders for ALKBH5 Gene

No disorders were found for ALKBH5 Gene.

No data available for UniProtKB/Swiss-Prot for ALKBH5 Gene

Publications for ALKBH5 Gene

  1. Structures of human ALKBH5 demethylase reveal a unique binding mode for specific single-stranded N6-methyladenosine RNA demethylation. (PMID: 24778178) Xu C. … Min J. (J. Biol. Chem. 2014) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Human AlkB homologue 5 is a nuclear 2-oxoglutarate dependent oxygenase and a direct target of hypoxia-inducible factor 1alpha (HIF- 1alpha). (PMID: 21264265) Thalhammer A. … Pollard P.J. (PLoS ONE 2011) 3 4
  5. Genes in a refined Smith-Magenis syndrome critical deletion interval on chromosome 17p11.2 and the syntenic region of the mouse. (PMID: 11997338) Bi W. … Lupski J.R. (Genome Res. 2002) 2 3

Products for ALKBH5 Gene

Sources for ALKBH5 Gene

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