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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ALKBH5 Gene

protein-coding   GIFtS: 43
GCID: GC17P018086

AlkB, Alkylation Repair Homolog 5 (E. Coli)

(Previous name: oxoglutarate and iron-dependent oxygenase domain containing)
(Previous symbol: OFOXD1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
AlkB, Alkylation Repair Homolog 5 (E. Coli)1 2     Alpha-Ketoglutarate-Dependent Dioxygenase AlkB Homolog 52 3
OFOXD11 2 3     OFOXD2
ABH52 3 5     Probable Alpha-Ketoglutarate-Dependent Dioxygenase ABH52
Oxoglutarate And Iron-Dependent Oxygenase Domain Containing1 2     RNA Demethylase ALKBH52
Alkylated DNA Repair Protein AlkB Homolog 52 3     EC 1.14.11.-3

External Ids:    HGNC: 259961   Entrez Gene: 548902   Ensembl: ENSG000000915427   OMIM: 6133035   UniProtKB: Q6P6C23   

Export aliases for ALKBH5 gene to outside databases

Previous GC identifers: GC17P018031 GC17P017840


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ALKBH5 Gene: 
ALKBH5 (alkB, alkylation repair homolog 5 (E. coli)) is a protein-coding gene. Diseases associated with ALKBH5 include smith magenis syndrome, and hypoxia. GO annotations related to this gene include oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen and oxidative RNA demethylase activity.

UniProtKB/Swiss-Prot: ALKB5_HUMAN, Q6P6C2
Function: Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates
N(6)-methyladenosine (m(6)A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher
eukaryotes. Requires molecular oxygen, alpha-ketoglutarate and iron. Demethylation of m(6)A mRNA affects mRNA
processing and export and is required for spermatogenesis




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.2  NT_010718.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ALKBH5 gene promoter:
         Pax-5   HTF   Pax-2   Pax-2a   XBP-1   Tal-1beta   Max   HEN1   ITF-2   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidALKBH5 promoter sequence
   Search SABiosciences Chromatin IP Primers for ALKBH5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ALKBH5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p11.2|17p11.2   Ensembl cytogenetic band:  17p11.2   HGNC cytogenetic band: 17p11.2

ALKBH5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ALKBH5 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P018086:  view genomic region     (about GC identifiers)

Start:
18,086,392 bp from pter      End:
18,113,268 bp from pter
Size:
26,877 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ALKB5_HUMAN, Q6P6C2 (See protein sequence)
Recommended Name: RNA demethylase ALKBH5  
Size: 394 amino acids; 44256 Da
Cofactor: Binds 1 Fe(2+) ion per subunit (By similarity)
Subcellular location: Nucleus speckle
Sequence caution: Sequence=BAA91078.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B4DVJ4 D3DXC6 Q9NXD6
Alternative splicing: 3 isoforms:  Q6P6C2-2   Q6P6C2-1   Q6P6C2-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ALKBH5: NX_Q6P6C2

Explore proteomics data for ALKBH5 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6P6C2

  • ALKBH5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ALKBH5 Protein Expression
    REFSEQ proteins: NP_060228.3  
    ENSEMBL proteins: 
     ENSP00000468116   ENSP00000382091  

    Human Recombinant Protein Products for ALKBH5: 
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    Cloud-Clone Corp. Proteins for ALKBH5 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0016607nuclear speck IDA--

    ALKBH5 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ALKB: Alkylation repair homologs

    1 InterPro protein domain:
     IPR027450 AlkB-like

    Graphical View of Domain Structure for InterPro Entry Q6P6C2

    ProtoNet protein and cluster: Q6P6C2

    UniProtKB/Swiss-Prot: ALKB5_HUMAN, Q6P6C2
    Similarity: Belongs to the alkB family


    ALKBH5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ALKB5_HUMAN, Q6P6C2
    Function: Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates
    N(6)-methyladenosine (m(6)A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher
    eukaryotes. Requires molecular oxygen, alpha-ketoglutarate and iron. Demethylation of m(6)A mRNA affects mRNA
    processing and export and is required for spermatogenesis
    Induction: By hypoxia, directly activated by HIF1A. Expression is regulated by PRMT7

         Enzyme Number (IUBMB): EC 1.14.11.-1

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016702oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ----
    GO:0016706oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors IDA--
    GO:0035515oxidative RNA demethylase activity IDA--
    GO:0046872metal ion binding IEA--
         
    ALKBH5 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ALKBH5:
     Increased gamma-H2AX phosphory 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Alkbh5):
     cellular  endocrine/exocrine gland  reproductive system 

    ALKBH5 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Alkbh5tm1.1Klng for ALKBH5

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ALKBH5 
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    SwitchGear 3'UTR luciferase reporter plasmidALKBH5 3' UTR sequence
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALKBH5


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ALKBH5

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for ALKBH5 (ENSP000003820914) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SIRT5ENSP000003685524STRING: ENSP00000368552
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001666response to hypoxia IDA--
    GO:0006397mRNA processing IMP--
    GO:0006406mRNA export from nucleus IMP--
    GO:0007283spermatogenesis ISS--
    GO:0030154cell differentiation IEA--

    ALKBH5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ALKBH5 (ALKB5)

    Search CenterWatch for drugs/clinical trials and news about ALKBH5 / ALKB5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ALKBH5 gene: 
    NM_017758.3  

    Unigene Cluster for ALKBH5:

    AlkB, alkylation repair homolog 5 (E. coli)
    Hs.744130  [show with all ESTs]
    Unigene Representative Sequence: NM_017758
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000541285 ENST00000399138(uc010cpw.3) ENST00000490106
    miRNA
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    8/58 QIAGEN miScript miRNA Assays for microRNAs that regulate ALKBH5 (see all 58):
    hsa-miR-302d hsa-miR-520e hsa-miR-3607-3p hsa-miR-193a-3p hsa-miR-1197 hsa-miR-890 hsa-miR-372 hsa-miR-3122
    SwitchGear 3'UTR luciferase reporter plasmidALKBH5 3' UTR sequence
    Inhib. RNA
    Products:
         
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ALKBH5
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ALKBH5

    Additional mRNA sequence: 

    AK000129.1 AK000315.1 AK025817.1 AK301107.1 AK311161.1 AK311511.1 AL137263.1 BC062339.1 

    10 DOTS entries:

    DT.91756074  DT.450045  DT.101971120  DT.95276932  DT.101984043  DT.100801733  DT.120974994  DT.75123302 
    DT.97847646  DT.95335833 

    24/398 AceView cDNA sequences (see all 398):

    BU955890 AI478159 AI190682 AI436617 AI422312 AI701712 AI085647 BP345833 
    AA687430 BM852561 AW271663 CB142278 F29457 BM424205 AI797503 AK000129 
    AA593173 BE856479 BE906834 BU740432 AI565397 BI793209 AA323000 AI075377 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ALKBH5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATCCAAGGC
    ALKBH5 Expression
    About this image


    See ALKBH5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ALKBH5

    SOURCE GeneReport for Unigene cluster: Hs.744130

    UniProtKB/Swiss-Prot: ALKB5_HUMAN, Q6P6C2
    Tissue specificity: Widely expressed, with highest expression in lung, followed by testis, pancreas, spleen and
    ovary

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ALKBH5 gene from 5/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Alkbh51 , 5 alkB, alkylation repair homolog 5 (E. coli)1, 5 91.46(n)1
    97.21(a)1
      11 (37.81 cM)5
    2684201  NM_172943.41  NP_766531.21 
     605363815 
    chicken
    (Gallus gallus)
    Aves ALKBH51 alkB, alkylation repair homolog 5 (E. coli) 78.35(n)
    86.25(a)
      770703  XM_001233462.2  XP_001233463.1 
    lizard
    (Anolis carolinensis)
    Reptilia ALKBH56
    Uncharacterized protein
    81(a)
    1 ↔ 1
    GL343618.1(19987-37398)
    African clawed frog
    (Xenopus laevis)
    Amphibia 480482982   -- 84.87(n)    48048298 
    zebrafish
    (Danio rerio)
    Actinopterygii CK147300.12   -- 78.84(n)    CK147300.1 


    ENSEMBL Gene Tree for ALKBH5 (if available)
    TreeFam Gene Tree for ALKBH5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/572 SNPs in ALKBH5 are shown (see all 572)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs739808161,2
    C,F--18084876(+) AGCGGC/TTTCTT 1 -- us2k12Minor allele frequency- T:0.10WA 120
    rs1510815931,2
    --18084904(+) GTTGAA/GCCAAA 1 -- us2k10--------
    rs1154223771,2
    F--18084999(+) TGCTCT/CTGAGC 1 -- us2k11Minor allele frequency- C:0.02WA 118
    rs1813497651,2
    --18085182(+) CCTCAC/TTGAAT 1 -- us2k10--------
    rs9973151,2
    C,F,A,H--18085286(-) GCCACT/CGCGCC 1 -- us2k110Minor allele frequency- C:0.14NS EA NA WA CSA 657
    rs1860185791,2
    --18085304(+) TGTAAC/TCCCAG 1 -- us2k10--------
    rs1909419511,2
    --18085469(+) GTGTGA/GGAGGA 1 -- us2k10--------
    rs1398680521,2
    --18085495(+) AGGTCA/GAGATT 1 -- us2k10--------
    rs1168163261,2
    C,F--18085700(+) TACAGG/AATGAG 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1498366601,2
    --18085868(+) TTGGAG/TCCCTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ALKBH5 (18086392 - 18113268 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for ALKBH5:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv510702CNV Loss20534489
    dgv3078n71CNV Loss21882294
    dgv3077n71CNV Loss21882294
    nsv155OTHER Inversion15895083
    nsv499114OTHER Inversion21111241

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 613303    OMIM disorders: --

    2 diseases for ALKBH5:    About MalaCards
    smith magenis syndrome    hypoxia


    ALKBH5 for disorders           About GeneDecksing


    Export disorders for ALKBH5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ALKBH5 gene, integrated from 9 sources (see all 22):
    (articles sorted by number of sources associating them with ALKBH5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility. (PubMed id 23177736)1, 2 Zheng G.... He C. (2013)
    2. Human AlkB homologue 5 is a nuclear 2-oxoglutarate de pendent oxygenase and a direct target of hypoxia-inducible factor 1I+ (HIF-1I+). (PubMed id 21264265)1, 2 Thalhammer A....Pollard P.J. (2011)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Genes in a refined Smith-Magenis syndrome critical deletion interval on chromosome 17p11.2 and the syntenic region of the mouse. (PubMed id 11997338)1, 3 Bi W....Lupski J.R. (2002)
    6. Protein arginine methyltransferase 7 regulates cellular response to DNA damage by methylating promoter histones H2A and H4 of the polymerase delta catalytic subunit gene, POLD1. (PubMed id 22761421)2 Karkhanis V.... Sif S. (2012)
    7. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (2012)
    8. Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
    9. A bead-based approach for large-scale identification o f in vitro kinase substrates. (PubMed id 22113938)1 Zhang M....Zou H. (2011)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54890 HGNC: 25996 AceView: FLJ20308 Ensembl:ENSG00000091542 euGenes: HUgn54890
    ECgene: ALKBH5 H-InvDB: ALKBH5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ALKBH5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ALKBH5 gene:
    Search GeneIP for patents involving ALKBH5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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