Aliases for ALKBH5 Gene
External Ids for ALKBH5 Gene
Previous HGNC Symbols for ALKBH5 Gene
Previous GeneCards Identifiers for ALKBH5 Gene
GeneCards Summary for ALKBH5 Gene
ALKBH5 (AlkB Family Member 5, RNA Demethylase) is a Protein Coding gene. GO annotations related to this gene include oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors and oxidative RNA demethylase activity.
UniProtKB/Swiss-Prot for ALKBH5 Gene
Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (PubMed:23177736, PubMed:24778178, PubMed:24616105, PubMed:24489119). Can also demethylate N(6)-methyladenosine in single-stranded DNA (in vitro) (PubMed:24616105). Requires molecular oxygen, alpha-ketoglutarate and iron (PubMed:21264265, PubMed:23177736, PubMed:24778178, PubMed:24616105, PubMed:24489119). Demethylation of m6A mRNA affects mRNA processing and export (PubMed:23177736). Required for spermatogenesis (By similarity).