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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ALKBH3 Gene

protein-coding   GIFtS: 57
GCID: GC11P043859

AlkB, Alkylation Repair Homolog 3 (E. Coli)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
AlkB, Alkylation Repair Homolog 3 (E. Coli)1 2     PCA12 5
ABH32 3 5     Alpha-Ketoglutarate-Dependent Dioxygenase AlkB Homolog 32
DEPC12 3 5     Prostate Cancer Antigen-12
Alkylated DNA Repair Protein AlkB Homolog 32 3     EC 1.14.11.-3
Prostate Cancer Antigen 12 3     EC 1.14.118
DEPC-12 3     

External Ids:    HGNC: 301411   Entrez Gene: 2211202   Ensembl: ENSG000001661997   OMIM: 6106035   UniProtKB: Q96Q833   

Export aliases for ALKBH3 gene to outside databases

Previous GC identifer: GC11P043611


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ALKBH3 Gene:
The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the
specific DNA lesions generated in single-stranded DNA. ALKBH2 (MIM 610602) and ALKBH3 are E. coli AlkB homologs
that catalyze the removal of 1-methyladenine and 3-methylcytosine (Duncan et al., 2002 (PubMed
12486230)).(supplied by OMIM, Mar 2008)

GeneCards Summary for ALKBH3 Gene: 
ALKBH3 (alkB, alkylation repair homolog 3 (E. coli)) is a protein-coding gene. Diseases associated with ALKBH3 include prostate cancer, and prostatitis, and among its related super-pathways are Reversal of Alkylation Damage By DNA Dioxygenases and Nucleotide Excision Repair. GO annotations related to this gene include oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen and ferrous iron binding. An important paralog of this gene is ALKBH2.

UniProtKB/Swiss-Prot: ALKB3_HUMAN, Q96Q83
Function: Dioxygenase that repairs alkylated DNA containing 1-methyladenine (1meA) and 3-methylcytosine (3meC) by
oxidative demethylation. Has a strong preference for single-stranded DNA. Able to process alkylated 3mC within
double-stranded regions via its interaction with ASCC3, which promotes DNA unwinding to generate single-stranded
substrate needed for ALKHB3. May also act on RNA. Requires molecular oxygen, alpha-ketoglutarate and iron




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_009237.18  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ALKBH3 gene promoter:
         HFH-3   Max1   C/EBPbeta   FOXL1   FOXI1   AREB6   PPAR-gamma1   POU2F1   POU2F1a   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidALKBH3 promoter sequence
   Search SABiosciences Chromatin IP Primers for ALKBH3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ALKBH3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p11.2   Ensembl cytogenetic band:  11p11.2   HGNC cytogenetic band: 11p11.2

ALKBH3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ALKBH3 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P043859:  view genomic region     (about GC identifiers)

Start:
43,902,357 bp from pter      End:
43,941,825 bp from pter
Size:
39,469 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ALKB3_HUMAN, Q96Q83 (See protein sequence)
Recommended Name: Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3  
Size: 286 amino acids; 33375 Da
Cofactor: Binds 1 Fe(2+) ion per subunit
Subunit: Interacts with the TRIP4 complex, notably composed of ASCC3
Subcellular location: Cytoplasm. Nucleus
Sequence caution: Sequence=AAH15155.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for ALKBH3:
2IUW (3D)    
Secondary accessions: A6NDJ1 Q3SYI0 Q6NX57 Q96BU8
Alternative splicing: 2 isoforms:  Q96Q83-1   Q96Q83-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ALKBH3: NX_Q96Q83

Explore proteomics data for ALKBH3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96Q83

  • 2 DME Specific Peptides for ALKBH3 (Q96Q83)
     FEMRKKPPPE  NLTFRTVYPDPRGA 

    ALKBH3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ALKBH3 Protein Expression
    REFSEQ proteins: NP_631917.1  
    ENSEMBL proteins: 
     ENSP00000434832   ENSP00000302232   ENSP00000432259   ENSP00000434229   ENSP00000436788  
     ENSP00000435848   ENSP00000433614   ENSP00000368117  
    Reactome Protein details: Q96Q83
    Human Recombinant Protein Products for ALKBH3: 
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    Novus Biologicals ALKBH3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for ALKBH3
    Cloud-Clone Corp. Proteins for ALKBH3 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion IDA--

    ALKBH3 for ontologies           About GeneDecksing



    ALKBH3 Antibody Products: 
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    Cloud-Clone Corp. CLIAs for ALKBH3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ALKB: Alkylation repair homologs

    2 InterPro protein domains:
     IPR027450 AlkB-like
     IPR005123 Oxoglu/Fe-dep_dioxygenase

    Graphical View of Domain Structure for InterPro Entry Q96Q83

    ProtoNet protein and cluster: Q96Q83

    UniProtKB/Swiss-Prot: ALKB3_HUMAN, Q96Q83
    Similarity: Belongs to the alkB family
    Similarity: Contains 1 Fe2OG dioxygenase domain


    ALKBH3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ALKB3_HUMAN, Q96Q83
    Function: Dioxygenase that repairs alkylated DNA containing 1-methyladenine (1meA) and 3-methylcytosine (3meC) by
    oxidative demethylation. Has a strong preference for single-stranded DNA. Able to process alkylated 3mC within
    double-stranded regions via its interaction with ASCC3, which promotes DNA unwinding to generate single-stranded
    substrate needed for ALKHB3. May also act on RNA. Requires molecular oxygen, alpha-ketoglutarate and iron
    Enzyme regulation: Activated by ascorbate

         Enzyme Numbers (IUBMB): EC 1.14.11.-1 EC 1.14.112

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0008198ferrous iron binding IDA16858410
    GO:0016491oxidoreductase activity ----
    GO:0016702oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ----
    GO:0016706oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors ----
         
    ALKBH3 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ALKBH3:
     Decreased viability of wild-ty  Synthetic lethal with Ras 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Alkbh3):
     cellular  homeostasis/metabolism  mortality/aging  normal 

    ALKBH3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Alkbh3tm1Klng for ALKBH3

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ALKBH3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ALKBH3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ALKBH3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ALKBH3 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALKBH3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ALKBH3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Reversal of Alkylation Damage By DNA Dioxygenases
    Reversal of Alkylation Damage By DNA Dioxygenases0.67
    ABH3 mediated Reversal of Alkylation Damage0.50
    DNA Damage Reversal0.67
    2Nucleotide Excision Repair
    DNA Repair0.46

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    4        Reactome Pathways for ALKBH3
        Reversal of Alkylation Damage By DNA Dioxygenases
    DNA Repair
    DNA Damage Reversal
    ABH3 mediated Reversal of Alkylation Damage



    ALKBH3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ALKBH3

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006281DNA repair TAS--
    GO:0006307DNA dealkylation involved in DNA repair TAS--
    GO:0008283cell proliferation IMP--
    GO:0035552oxidative single-stranded DNA demethylation IMP--
    GO:0055114oxidation-reduction process ----

    ALKBH3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ALKBH3 (ALKB3)

    3 HMDB Compounds for ALKBH3    About this table
    CompoundSynonyms CAS #PubMed Ids
    2-Ketobutyric acid2-Ketobutanoate (see all 35)600-18-0--
    Ascorbic acid(+)-ascorbate (see all 140)50-81-7--
    IronArmco iron (see all 19)7439-89-6--

    1 DrugBank Compound for ALKBH3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Vitamin CAscorbate (see all 6)50-81-7target--17139284 17016423

    Search CenterWatch for drugs/clinical trials and news about ALKBH3 / ALKB3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ALKBH3 gene: 
    NM_139178.3  

    Unigene Cluster for ALKBH3:

    AlkB, alkylation repair homolog 3 (E. coli)
    Hs.720708  [show with all ESTs]
    Unigene Representative Sequence: NM_139178
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000532962 ENST00000527029 ENST00000302708(uc001mxs.2) ENST00000534171
    ENST00000524742 ENST00000530803(uc009ykp.2 uc001mxt.2) ENST00000529366
    ENST00000533200 ENST00000530754 ENST00000532410 ENST00000532129 ENST00000529434
    ENST00000378840
    miRNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ALKBH3
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    Additional mRNA sequence: 

    AB042029.1 AK315266.1 BC015155.1 BC103812.1 BC103813.1 BC103814.2 U38442.1 

    9 DOTS entries:

    DT.408906  DT.408905  DT.97814631  DT.100667455  DT.100022953  DT.100722566  DT.91969156  DT.99950929 
    DT.99951860 

    24/160 AceView cDNA sequences (see all 160):

    CR612017 CR615997 AI572836 BE891036 BP340582 CR623815 BP338899 BU784435 
    BE274419 AI700490 BE296263 AA569865 CR621454 BU553708 CR602476 AW135325 
    BE269759 BU838356 CD672147 AL551979 AW070233 AI354518 BE293567 BQ375279 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for ALKBH3 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c
    SP1:                    -                                                           -     -                                       
    SP2:                    -                                                     -           -                                       
    SP3:                    -                                                     -     -     -                                       
    SP4:                                                                          -     -     -                                       
    SP5:                                                                          -     -                                             


    ECgene alternative splicing isoforms for ALKBH3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ALKBH3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGGTAATAG
    ALKBH3 Expression
    About this image


    See ALKBH3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ALKBH3

    SOURCE GeneReport for Unigene cluster: Hs.720708

    UniProtKB/Swiss-Prot: ALKB3_HUMAN, Q96Q83
    Tissue specificity: Ubiquitous. Detected in heart, pancreas, skeletal muscle, thymus, testis, ovary, spleen,
    prostate, small intestine, peripheral blood leukocytes, urinary bladder and colon

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALKBH3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ALKBH3 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Alkbh31 , 5 alkB, alkylation repair homolog 3 (E. coli)1, 5 84.8(n)1
    85.96(a)1
      2 (51.62 cM)5
    691131  NM_026944.11  NP_081220.11 
     939805505 
    chicken
    (Gallus gallus)
    Aves ALKBH31 alkB, alkylation repair homolog 3 (E. coli) 68.56(n)
    69.4(a)
      423169  XM_421095.3  XP_421095.3 
    lizard
    (Anolis carolinensis)
    Reptilia ALKBH36
    Uncharacterized protein
    51(a)
    1 ↔ 1
    1(45349157-45368928)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia 1420334112   -- 72.5(n)    142033411 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.145292 Transcribed sequence with weak similarity to protein more 76.53(n)    BI708780.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G222601 oxidoreductase, 2OG-Fe(II) oxygenase-like protein 45.97(n)
    36.81(a)
      816759  NM_127792.3  NP_565530.1 
    rice
    (Oryza sativa)
    Liliopsida Os06g02863101 hypothetical protein 46.79(n)
    43.59(a)
      9272524  NM_001187793.1  NP_001174722.1 


    ENSEMBL Gene Tree for ALKBH3 (if available)
    TreeFam Gene Tree for ALKBH3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ALKBH3 gene
    ALKBH22  

    ALKBH3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/610 SNPs in ALKBH3 are shown (see all 610)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0266314
    ----see VAR_0266312 D E mis40--------
    rs47557511,2
    C,F,A,H--43900360(+) GGGTGC/TCATGG 1 -- us2k15Minor allele frequency- T:0.05NS EA NA 536
    rs1400569641,2
    --43900366(+) CATGGA/GTGTTC 1 -- us2k10--------
    rs1420595231,2
    --43900508(+) CACTGC/TGGGCC 1 -- us2k10--------
    rs357373711,2
    C,F--43900824(+) GGATGC/TCAAGA 1 -- us2k15Minor allele frequency- T:0.01NS 186
    rs343939841,2
    C,F--43900833(+) GACCAT/CTAAGA 1 -- us2k16Minor allele frequency- C:0.02NS WA 304
    rs342418631,2
    C,F--43900864(+) GCATCG/ATCTAG 1 -- us2k16Minor allele frequency- A:0.02NS WA 306
    rs343774101,2
    C,F--43900981(+) CCTACA/GTATGT 1 -- us2k16Minor allele frequency- G:0.02NS WA 300
    rs339987651,2
    C--43900984(+) ACATAT/CGTCCT 1 -- us2k16Minor allele frequency- C:0.01NS WA 300
    rs112888021,2
    C,F--43901062(+) AAAAAA/-GCAGT 1 -- us2k1 trp38Minor allele frequency- -:0.09NA NS 188

    HapMap Linkage Disequilibrium report for ALKBH3 (43902357 - 43941825 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for ALKBH3:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2028436CNV Deletion18987734
    esv2663316CNV Deletion23128226
    esv2744413CNV Deletion23290073
    esv2616474CNV Deletion19546169
    esv272089CNV Insertion20981092
    esv6093CNV Loss19470904
    nsv832138CNV Gain17160897
    nsv467867CNV Gain19166990

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610603    OMIM disorders: --

    6 diseases for ALKBH3:    About MalaCards
    prostate cancer    prostatitis    tuberculosis    lung cancer
    pancreatic cancer    pancreatitis

    1 disease from the University of Copenhagen DISEASES database for ALKBH3:
    Mucoepidermoid carcinoma

    ALKBH3 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for ALKBH3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prostate cancer 32.5 10 18077911 (2), 17968469 (2), 17970783 (1), 16033822 (1)

    Genetic Association Database (GAD): ALKBH3
    Human Genome Epidemiology (HuGE) Navigator: ALKBH3 (2 documents)

    Export disorders for ALKBH3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ALKBH3 gene, integrated from 9 sources (see all 28):
    (articles sorted by number of sources associating them with ALKBH3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. DNA unwinding by ASCC3 helicase is coupled to ALKBH3- dependent DNA alkylation repair and cancer cell proliferation. (PubMed id 22055184)1, 2 Dango S....Shi Y. (2011)
    2. Human ABH3 structure and key residues for oxidative demethylation to reverse DNA/RNA damage. (PubMed id 16858410)1, 2 Sundheim O.... Slupphaug G. (2006)
    3. Repair of methylation damage in DNA and RNA by mammalian AlkB homologues. (PubMed id 16174769)1, 2 Lee D.-H.... O'Connor T.R. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA. (PubMed id 12594517)1, 2 Aas P.A....Krokan H.E. (2003)
    6. Reversal of DNA alkylation damage by two human dioxygenases. (PubMed id 12486230)1, 2 Duncan T....Sedgwick B. (2002)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    8. Prostate cancer antigen-1 as a potential novel marker for prostate cancer. (PubMed id 17968469)1, 9 Liu B.Q....Liu R.L. (2007)
    9. PCA-1/ALKBH3 contributes to pancreatic cancer by suppo rting apoptotic resistance and angiogenesis. (PubMed id 22826605)1 Yamato I....Nakajima Y. (2012)
    10. ALKBH3 contributes to survival and angiogenesis of hum an urothelial carcinoma cells through NADPH oxidase and tweak/Fn14/VEGF signals. (PubMed id 22850567)1 Shimada K....Konishi N. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 221120 HGNC: 30141 AceView: DEPC-1 Ensembl:ENSG00000166199 euGenes: HUgn221120
    ECgene: ALKBH3 H-InvDB: ALKBH3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ALKBH3 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/depc1/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ALKBH3 gene:
    Search GeneIP for patents involving ALKBH3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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