Aliases for ALKBH3 Gene
External Ids for ALKBH3 Gene
Previous GeneCards Identifiers for ALKBH3 Gene
The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA. ALKBH2 (MIM 610602) and ALKBH3 are E. coli AlkB homologs that catalyze the removal of 1-methyladenine and 3-methylcytosine (Duncan et al., 2002 [PubMed 12486230]).[supplied by OMIM, Mar 2008]
GeneCards Summary for ALKBH3 Gene
ALKBH3 (AlkB, Alkylation Repair Homolog 3 (E. Coli)) is a Protein Coding gene. Diseases associated with ALKBH3 include prostate cancer. Among its related pathways are DNA Repair and DNA Repair. GO annotations related to this gene include L-ascorbic acid binding and DNA-N1-methyladenine dioxygenase activity. An important paralog of this gene is ALKBH2.
UniProtKB/Swiss-Prot for ALKBH3 Gene
Dioxygenase that repairs alkylated DNA containing 1-methyladenine (1meA) and 3-methylcytosine (3meC) by oxidative demethylation. Has a strong preference for single-stranded DNA. Able to process alkylated 3mC within double-stranded regions via its interaction with ASCC3, which promotes DNA unwinding to generate single-stranded substrate needed for ALKHB3. May also act on RNA. Requires molecular oxygen, alpha-ketoglutarate and iron.