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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ALKBH3 Gene

protein-coding   GIFtS: 53
GCID: GC11P043859

alkB, alkylation repair homolog 3 (E. coli)
 Explore 7 diseases affiliated with
ALKBH3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ALKBH3    

Aliases
for ALKBH3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
AlkB, Alkylation Repair Homolog 3 (E. Coli)1 2     PCA12 5
DEPC-11 2 3     Alpha-Ketoglutarate-Dependent Dioxygenase AlkB Homolog 32
ABH32 3 5     Prostate Cancer Antigen-12
DEPC12 3 5     EC 1.14.11.-3
Alkylated DNA Repair Protein AlkB Homolog 32 3     EC 1.14.118
Prostate Cancer Antigen 12 3     

External Ids:    HGNC: 301411   Entrez Gene: 2211202   Ensembl: ENSG000001661997   OMIM: 6106035   UniProtKB: Q96Q833   

Export aliases for ALKBH3 gene to outside databases

Previous GC identifer: GC11P043611


Summaries
for ALKBH3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ALKBH3:
The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA
lesions generated in single-stranded DNA. ALKBH2 (MIM 610602) and ALKBH3 are E. coli AlkB homologs that catalyze the
removal of 1-methyladenine and 3-methylcytosine (Duncan et al., 2002 (PubMed 12486230)).(supplied by OMIM, Mar 2008)

UniProtKB/Swiss-Prot: ALKB3_HUMAN, Q96Q83
Function: Dioxygenase that repairs alkylated DNA containing 1-methyladenine (1meA) and 3-methylcytosine (3meC) by
oxidative demethylation. Has a strong preference for single-stranded DNA. Able to process alkylated 3mC within
double-stranded regions via its interaction with ASCC3, which promotes DNA unwinding to generate single-stranded
substrate needed for ALKHB3. May also act on RNA. Requires molecular oxygen, alpha-ketoglutarate and iron




Genomic Views
for ALKBH3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_009237.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ALKBH3 gene promoter:
         HFH-3   Max1   C/EBPbeta   FOXL1   FOXI1   AREB6   PPAR-gamma1   POU2F1   POU2F1a   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ALKBH3 promoter sequence
   Search SABiosciences Chromatin IP Primers for ALKBH3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ALKBH3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p11.2   Ensembl cytogenetic band:  11p11.2   HGNC cytogenetic band: 11p11.2

ALKBH3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ALKBH3 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P043859:  view genomic region     (about GC identifiers)

Start:
 43,902,357 bp from pter      End:
 43,941,825 bp from pter
Size:
 39,469 bases      Orientation:
 plus strand

Proteins
for ALKBH3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ALKB3_HUMAN, Q96Q83 (See protein sequence)
Recommended Name: Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3  
Size: 286 amino acids; 33375 Da
Cofactor: Binds 1 Fe(2+) ion per subunit
Subunit: Interacts with the TRIP4 complex, notably composed of ASCC3
Subcellular location: Cytoplasm. Nucleus
Sequence caution: Sequence=AAH15155.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for ALKBH3:
2IUW (3D)    
Secondary accessions: A6NDJ1 Q3SYI0 Q6NX57 Q96BU8
Alternative splicing: 2 isoforms:  Q96Q83-1   Q96Q83-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ALKBH3: NX_Q96Q83

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96Q83

    • 2 DME Specific Peptides for ALKBH3 (Q96Q83)
     FEMRKKPPPE  NLTFRTVYPDPRGA 

    ALKBH3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_631917.1  
    ENSEMBL proteins: 
     ENSP00000434832   ENSP00000302232   ENSP00000432259   ENSP00000434229   ENSP00000436788  
     ENSP00000435848   ENSP00000433614   ENSP00000368117  
    Reactome Protein details: Q96Q83
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Protein: ALKBH3
    OriGene Protein Over-expression Lysate: ALKBH3
    OriGene Custom Protein Services for ALKBH3 
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    Novus Biologicals ALKBH3 Proteins
    Novus Biologicals ALKBH3 Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for ALKBH3
    Uscn Proteins for ALKBH3

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IDA--
    GO:0005739mitochondrion IDA--


    ALKBH3 for ontologies           About GeneDecksing



    ALKBH3 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of ALKBH3
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    Abcam antibodies for ALKBH3 
    Uscn Antibodies for ALKBH3
    Search ThermoFisher Antibodies for ALKBH3

    Assay Products for ALKBH3: 
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    Uscn ELISAs and CLIAs for ALKBH3

    Protein Domains /
    Families
    for ALKBH3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ALKBH3 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR005123 Oxoglu/Fe-dep_dioxygenase

    Graphical View of Domain Structure for InterPro Entry Q96Q83

    ProtoNet protein and cluster: Q96Q83

    UniProtKB/Swiss-Prot: ALKB3_HUMAN, Q96Q83
    Similarity: Belongs to the alkB family
    Similarity: Contains 1 Fe2OG dioxygenase domain


    Function
    for ALKBH3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ALKB3_HUMAN, Q96Q83
    Function: Dioxygenase that repairs alkylated DNA containing 1-methyladenine (1meA) and 3-methylcytosine (3meC) by
    oxidative demethylation. Has a strong preference for single-stranded DNA. Able to process alkylated 3mC within
    double-stranded regions via its interaction with ASCC3, which promotes DNA unwinding to generate single-stranded
    substrate needed for ALKHB3. May also act on RNA. Requires molecular oxygen, alpha-ketoglutarate and iron
    Enzyme regulation: Activated by ascorbate

    Enzyme Numbers (IUBMB): EC 1.14.11.-1 EC 1.14.112

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmid: ALKBH3 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ALKBH3 (see all 7)
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    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ALKBH3

    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALKBH3 

    Cell Line
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    Search LifeMap BioReagents cell lines for ALKBH3

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALKBH3

    Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0008198ferrous iron binding IDA16858410
    GO:0016702oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen IEA--
    GO:0016706oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors ----
    GO:0031418L-ascorbic acid binding IEA--


    ALKBH3 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for ALKBH3:
     Decreased viability of wild-ty  Synthetic lethal with Ras 

    Animal Models:
         Mouse knock-out Alkbh3tm1Klng for ALKBH3
         4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Alkbh3):
     cellular  homeostasis/metabolism  mortality/aging  normal 

    ALKBH3 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for ALKBH3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Reversal of Alkylation Damage By DNA Dioxygenases
    		Reversal of Alkylation Damage By DNA Dioxygenases1.00
    		ABH3 mediated Reversal of Alkylation Damage0.50
    		DNA Damage Reversal0.67
    2Nucleotide Excision Repair
    		DNA Repair0.46

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    4        Reactome Pathways for ALKBH3
        Reversal of Alkylation Damage By DNA Dioxygenases
    DNA Repair
    DNA Damage Reversal
    ABH3 mediated Reversal of Alkylation Damage



    ALKBH3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ALKBH3

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006281DNA repair TAS--
    GO:0006307DNA dealkylation involved in DNA repair TAS--
    GO:0008283cell proliferation IMP--
    GO:0035552oxidative single-stranded DNA demethylation IMP--


    ALKBH3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ALKBH3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ALKBH3

    3 HMDB Compounds for ALKBH3    About this table
    CompoundSynonyms CAS #PubMed Ids
    2-Ketobutyric acid2-Ketobutanoate (see all 35)600-18-0--
    Ascorbic acid(+)-ascorbate (see all 140)50-81-7--
    IronArmco iron (see all 19)7439-89-6--

    1 DrugBank Compound for ALKBH3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Vitamin CAscorbate (see all 6)50-81-7target--17139284 17016423

    Search CenterWatch for drugs/clinical trials and news about ALKBH3 / ALKB3 

    Transcripts
    for ALKBH3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ALKBH3 gene: 
    NM_139178.3  

    Unigene Cluster for ALKBH3:

    AlkB, alkylation repair homolog 3 (E. coli)
    Hs.720708  [show with all ESTs]
    Unigene Representative Sequence: NM_139178
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000532962 ENST00000527029 ENST00000302708(uc001mxs.2) ENST00000534171
    ENST00000524742 ENST00000530803(uc009ykp.2 uc001mxt.2) ENST00000529366
    ENST00000533200 ENST00000530754 ENST00000532410 ENST00000532129 ENST00000529434
    ENST00000378840

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ALKBH3
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    SwitchGear 3'UTR luciferase reporter plasmid: ALKBH3 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ALKBH3 (see all 7)
    OriGene shRNA RFP: ALKBH3
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    Clone
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    Primer
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    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ALKBH3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ALKBH3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ALKBH3

    Additional cDNA sequence: 

    AB042029.1 AK315266.1 BC015155.1 BC103812.1 BC103813.1 BC103814.2 U38442.1 

    9 DOTS entries:

    DT.408906  DT.408905  DT.97814631  DT.100667455  DT.100022953  DT.100722566  DT.91969156  DT.99950929 
    DT.99951860 

    24/160 AceView cDNA sequences (see all 160):

    BP340582 AI572836 AI700490 BE891036 AW135325 CR602476 BE296263 CD672147 
    AL551979 AA569865 CR621454 BU784435 BU553708 BP338899 BE274419 BU838356 
    CR612017 BE269759 CR615997 CR623815 BI258292 BG772137 BE789024 BX501306 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for ALKBH3 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c
    SP1:                    -                                                           -     -                                       
    SP2:                    -                                                     -           -                                       
    SP3:                    -                                                     -     -     -                                       
    SP4:                                                                          -     -     -                                       
    SP5:                                                                          -     -                                             


    ECgene alternative splicing isoforms for ALKBH3

    Expression
    for ALKBH3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ALKBH3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTGGTAATAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See ALKBH3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ALKBH3

    SOURCE GeneReport for Unigene cluster: Hs.720708

    UniProtKB/Swiss-Prot: ALKB3_HUMAN, Q96Q83
    Tissue specificity: Ubiquitous. Detected in heart, pancreas, skeletal muscle, thymus, testis, ovary, spleen, prostate,
    small intestine, peripheral blood leukocytes, urinary bladder and colon

        SABiosciences Custom PCR Arrays for ALKBH3
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALKBH3

    Orthologs
    for ALKBH3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ALKBH3 gene from 6/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves ALKBH31 alkB, alkylation repair homolog 3 (E. coli) 68.56(n)
    69.4(a)    		   423169  XM_421095.3  XP_421095.3 
    lizard
    (Anolis carolinensis)    		 Reptilia ALKBH36
    		 --
    		 51(a)
    		 1 ↔ 1
    		 1(45349840-45368928)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia 1420334112   -- 72.5(n)    142033411 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.145292 Transcribed sequence with weak similarity to protein more 76.53(n)    BI708780.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT2G222601 oxidoreductase, 2OG-Fe(II) oxygenase-like protein 45.97(n)
    36.81(a)    		   816759  NM_127792.3  NP_565530.1 
    rice
    (Oryza sativa)    		 Liliopsida Os06g02863101 hypothetical protein 46.79(n)
    43.59(a)    		   9272524  NM_001187793.1  NP_001174722.1 


    ENSEMBL Gene Tree for ALKBH3 (if available)
    TreeFam Gene Tree for ALKBH3 (if available) 

    Paralogs
    for ALKBH3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ALKBH3 gene
    ALKBH22  

    ALKBH3 for paralogs           About GeneDecksing



    Genomic Variants
    for ALKBH3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/778 NCBI SNPs in ALKBH3 are shown (see all 778)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1124130141,2
    		C--43643846(+) CTCATAAGTCAACCA
    TGGTTCAAA    /-    AAGTC     		1 -- int11Minor allele frequency- -:0.50CSA 2
    rs47557511,2
    		C,F,A,H,--43900360(+) GGGTGC/TCATGG 1 -- us2k15Minor allele frequency- T:0.05NS EA NA 536
    rs1400569641,2
    		--43900366(+) CATGGA/GTGTTC 1 -- us2k10--------
    rs1420595231,2
    		--43900508(+) CACTGC/TGGGCC 1 -- us2k10--------
    rs357373711,2
    		C,--43900824(+) GGATGC/TCAAGA 1 -- us2k15Minor allele frequency- T:0.01NS 186
    rs343939841,2
    		C,F,--43900833(+) GACCAT/CTAAGA 1 -- us2k16Minor allele frequency- C:0.02NS WA 304
    rs342418631,2
    		C,F,--43900864(+) GCATCG/ATCTAG 1 -- us2k16Minor allele frequency- A:0.02NS WA 306
    rs343774101,2
    		C,F,--43900981(+) CCTACA/GTATGT 1 -- us2k16Minor allele frequency- G:0.02NS WA 300
    rs339987651,2
    		C,--43900984(+) ACATAT/CGTCCT 1 -- us2k16Minor allele frequency- C:0.01NS WA 300
    rs112888021,2
    		C,F--43901062(+) AAAAAA/-GCAGT 1 -- us2k1 trp38Minor allele frequency- -:0.09NA NS 188

    HapMap Linkage Disequilibrium report for ALKBH3 (43902357 - 43941825 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for ALKBH3
         1 CNV: 101206
         2 Indels: 61130 44898

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    Disorders / Diseases
    for ALKBH3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ALKBH3 for disorders           About GeneDecksing

    OMIM gene information: 610603    OMIM disorders: --

    7 diseases for ALKBH3:    About MalaCards
    prostate cancer    prostatitis    prostate carcinoma    lung cancer
    tuberculosis    carcinoma    mycobacterium tuberculosis

    1 Novoseek disease relationship for ALKBH3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prostate cancer 32.5 10 18077911 (2), 17968469 (2), 17970783 (1), 16033822 (1)

    Human Genome Epidemiology (HuGE) Navigator: ALKBH3 (2 documents)

    Export disorders for ALKBH3 gene to outside databases

    Publications
    for ALKBH3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ALKBH3 gene, integrated from 9 sources (see all 25):
    (articles sorted by number of sources associating them with ALKBH3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. DNA unwinding by ASCC3 helicase is coupled to ALKBH3- dependent DNA alkylation repair and cancer cell proliferation. (PubMed id 22055184)1, 2 Dango S....Shi Y. (2011)
    2. Human ABH3 structure and key residues for oxidative demethylation to reverse DNA/RNA damage. (PubMed id 16858410)1, 2 Sundheim O.... Slupphaug G. (2006)
    3. Repair of methylation damage in DNA and RNA by mammalian AlkB homologues. (PubMed id 16174769)1, 2 Lee D.-H.... O'Connor T.R. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA. (PubMed id 12594517)1, 2 Aas P.A....Krokan H.E. (2003)
    6. Reversal of DNA alkylation damage by two human dioxygenases. (PubMed id 12486230)1, 2 Duncan T....Sedgwick B. (2002)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    8. Prostate cancer antigen-1 as a potential novel marker for prostate cancer. (PubMed id 17968469)1, 9 Liu B.Q....Liu R.L. (2007)
    9. PCA-1/ALKBH3 contributes to pancreatic cancer by suppo rting apoptotic resistance and angiogenesis. (PubMed id 22826605)1 Yamato I....Nakajima Y. (2012)
    10. ALKBH3, a human AlkB homologue, contributes to cell s urvival in human non-small-cell lung cancer. (PubMed id 21285982)1 Tasaki M....Konishi N. (2011)

    External Searches for ALKBH3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ALKBH3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 221120 HGNC: 30141 AceView: DEPC-1 Ensembl:ENSG00000166199 euGenes: HUgn221120
    ECgene: ALKBH3 H-InvDB: ALKBH3

    Other Databases showing ALKBH3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ALKBH3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ALKBH3 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/depc1/

    Intellectual Property
    for ALKBH3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ALKBH3 gene:
    Search GeneIP for patents involving ALKBH3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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