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ALKBH3 Gene

protein-coding   GIFtS: 54
GCID: GC11P043902

AlkB, Alkylation Repair Homolog 3 (E. Coli)

  See ALKBH3-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
AlkB, Alkylation Repair Homolog 3 (E. Coli)1 2     PCA12 5
ABH32 3 5     Alpha-Ketoglutarate-Dependent Dioxygenase AlkB Homolog 32
DEPC12 3 5     Prostate Cancer Antigen-12
Alkylated DNA Repair Protein AlkB Homolog 32 3     EC 1.14.11.-3
Prostate Cancer Antigen 12 3     EC 1.14.118
DEPC-12 3     

External Ids:    HGNC: 301411   Entrez Gene: 2211202   Ensembl: ENSG000001661997   OMIM: 6106035   UniProtKB: Q96Q833   
ORGUL members:         

Export aliases for ALKBH3 gene to outside databases

Previous GC identifers: GC11P043859 GC11P043611


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ALKBH3 Gene:
The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the
specific DNA lesions generated in single-stranded DNA. ALKBH2 (MIM 610602) and ALKBH3 are E. coli AlkB homologs
that catalyze the removal of 1-methyladenine and 3-methylcytosine (Duncan et al., 2002 (PubMed
12486230)).(supplied by OMIM, Mar 2008)

GeneCards Summary for ALKBH3 Gene:
ALKBH3 (alkB, alkylation repair homolog 3 (E. coli)) is a protein-coding gene. Diseases associated with ALKBH3 include prostate cancer. GO annotations related to this gene include DNA-N1-methyladenine dioxygenase activity and L-ascorbic acid binding. An important paralog of this gene is ALKBH2.

UniProtKB/Swiss-Prot: ALKB3_HUMAN, Q96Q83
Function: Dioxygenase that repairs alkylated DNA containing 1-methyladenine (1meA) and 3-methylcytosine (3meC) by
oxidative demethylation. Has a strong preference for single-stranded DNA. Able to process alkylated 3mC within
double-stranded regions via its interaction with ASCC3, which promotes DNA unwinding to generate single-stranded
substrate needed for ALKHB3. May also act on RNA. Requires molecular oxygen, alpha-ketoglutarate and iron




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the ALKBH3 gene promoter:
         HFH-3   Max1   C/EBPbeta   FOXL1   FOXI1   AREB6   PPAR-gamma1   POU2F1   POU2F1a   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidALKBH3 promoter sequence
   Search Chromatin IP Primers for ALKBH3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ALKBH3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p11.2   Ensembl cytogenetic band:  11p11.2   HGNC cytogenetic band: 11p11.2

ALKBH3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ALKBH3 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P043902:  view genomic region     (about GC identifiers)

Start:
43,902,357 bp from pter      End:
43,941,825 bp from pter
Size:
39,469 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ALKB3_HUMAN, Q96Q83 (See protein sequence)
Recommended Name: Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3  
Size: 286 amino acids; 33375 Da
Cofactor: Binds 1 Fe(2+) ion per subunit
Subunit: Interacts with the TRIP4 complex, notably composed of ASCC3
Sequence caution: Sequence=AAH15155.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for ALKBH3:
2IUW (3D)    
Secondary accessions: A6NDJ1 Q3SYI0 Q6NX57 Q96BU8
Alternative splicing: 2 isoforms:  Q96Q83-1   Q96Q83-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ALKBH3: NX_Q96Q83

Explore proteomics data for ALKBH3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for ALKBH3 (Q96Q83)
     FEMRKKPPPE  NLTFRTVYPDPRGA 


    See ALKBH3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_631917.1  
    ENSEMBL proteins: 
     ENSP00000434832   ENSP00000302232   ENSP00000432259   ENSP00000434229   ENSP00000436788  
     ENSP00000435848   ENSP00000433614   ENSP00000368117  
    Reactome Protein details: Q96Q83

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ALKB: Alkylation repair homologs

    2 InterPro protein domains:
     IPR027450 AlkB-like
     IPR005123 Oxoglu/Fe-dep_dioxygenase

    Graphical View of Domain Structure for InterPro Entry Q96Q83

    ProtoNet protein and cluster: Q96Q83

    UniProtKB/Swiss-Prot: ALKB3_HUMAN, Q96Q83
    Similarity: Belongs to the alkB family
    Similarity: Contains 1 Fe2OG dioxygenase domain


    Find genes that share domains with ALKBH3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ALKB3_HUMAN, Q96Q83
    Function: Dioxygenase that repairs alkylated DNA containing 1-methyladenine (1meA) and 3-methylcytosine (3meC) by
    oxidative demethylation. Has a strong preference for single-stranded DNA. Able to process alkylated 3mC within
    double-stranded regions via its interaction with ASCC3, which promotes DNA unwinding to generate single-stranded
    substrate needed for ALKHB3. May also act on RNA. Requires molecular oxygen, alpha-ketoglutarate and iron
    Enzyme regulation: Activated by ascorbate

         Enzyme Numbers (IUBMB): EC 1.14.11.-1 EC 1.14.112

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
    GO:0008198ferrous iron binding IDA16858410
    GO:0016491oxidoreductase activity ----
    GO:0016706oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors ----
    GO:0031418L-ascorbic acid binding IEA--
         
    Find genes that share ontologies with ALKBH3           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for ALKBH3:
     Decreased viability of wild-ty  Synthetic lethal with Ras 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Alkbh3):
     cellular  homeostasis/metabolism  mortality/aging  normal 

    Find genes that share phenotypes with ALKBH3           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Alkbh3tm1Klng for ALKBH3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ALKBH3
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ALKB3_HUMAN, Q96Q83: Cytoplasm. Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    mitochondrion4
    cytosol3

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IEA--
    GO:0005739mitochondrion ----

    Find genes that share ontologies with ALKBH3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ALKBH3 About    
    See pathways by source

    SuperPathContained pathways About
    1DNA Repair
    DNA Repair0.45
    Reversal of Alkylation Damage By DNA Dioxygenases0.00
    DNA Damage Reversal0.00
    ABH3 mediated Reversal of Alkylation Damage0.00


    Find genes that share SuperPaths with ALKBH3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for ALKBH3
        ABH3 mediated Reversal of Alkylation Damage


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ALKBH3
    Interactions:

        Search GeneGlobe Interaction Network for ALKBH3

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006281DNA repair TAS--
    GO:0006307DNA dealkylation involved in DNA repair TAS--
    GO:0008283cell proliferation IMP--
    GO:0035552oxidative single-stranded DNA demethylation IMP--
    GO:0055114oxidation-reduction process ----

    Find genes that share ontologies with ALKBH3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ALKBH3 (ALKB3)

    3 HMDB Compounds for ALKBH3    About this table
    CompoundSynonyms CAS #PubMed Ids
    2-Ketobutyric acid2-Ketobutanoate (see all 35)600-18-0--
    Ascorbic acid(+)-ascorbate (see all 140)50-81-7--
    IronArmco iron (see all 19)7439-89-6--

    1 DrugBank Compound for ALKBH3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Vitamin CAscorbate (see all 6)50-81-7target--17139284 17016423



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ALKBH3 gene: 
    NM_139178.3  

    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000532962 ENST00000527029 ENST00000302708(uc001mxs.2) ENST00000534171
    ENST00000524742 ENST00000530803(uc009ykp.2 uc001mxt.2) ENST00000529366
    ENST00000533200 ENST00000530754 ENST00000532410 ENST00000532129 ENST00000529434
    ENST00000378840
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat ALKBH3
      QuantiFast Probe-based Assays in human, mouse, rat ALKBH3

    Selected AceView cDNA sequences (see all 160):

    CR623815 CR621454 BU553708 AI572836 BP340582 BU838356 AI700490 CD672147 
    BP338899 CR615997 AA569865 CR602476 BE274419 AL551979 BU784435 BE296263 
    AW135325 CR612017 BE269759 BE891036 BU602469 CA445168 BF346939 AI091812 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ALKBH3 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c
    SP1:                    -                                                           -     -                                       
    SP2:                    -                                                     -           -                                       
    SP3:                    -                                                     -     -     -                                       
    SP4:                                                                          -     -     -                                       
    SP5:                                                                          -     -                                             


    ECgene alternative splicing isoforms for ALKBH3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ALKBH3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGGTAATAG
    ALKBH3 Expression
    About this image

    ALKBH3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ALKBH3 Protein Expression

    UniProtKB/Swiss-Prot: ALKB3_HUMAN, Q96Q83
    Tissue specificity: Ubiquitous. Detected in heart, pancreas, skeletal muscle, thymus, testis, ovary, spleen,
    prostate, small intestine, peripheral blood leukocytes, urinary bladder and colon

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ALKBH3 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Alkbh31 , 5 alkB, alkylation repair homolog 3 (E. coli)1, 5 84.8(n)1
    85.96(a)1
      2 (51.62 cM)5
    691131  NM_026944.11  NP_081220.11 
     939805505 
    chicken
    (Gallus gallus)
    Aves ALKBH31 alkB, alkylation repair homolog 3 (E. coli) 67.85(n)
    67.97(a)
      423169  XM_421095.4  XP_421095.4 
    lizard
    (Anolis carolinensis)
    Reptilia ALKBH36
    alkB, alkylation repair homolog 3 (E. coli)
    50(a)
    1 ↔ 1
    1(45349157-45368928)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia 1420334112   -- 72.5(n)    142033411 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.145292 Transcribed sequence with weak similarity to protein more 76.53(n)    BI708780.1 


    ENSEMBL Gene Tree for ALKBH3 (if available)
    TreeFam Gene Tree for ALKBH3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ALKBH3 gene
    ALKBH22  

    Find genes that share paralogs with ALKBH3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ALKBH3 (see all 610)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs47557511,2
    C,F,A,H--43900360(+) GGGTGC/TCATGG 1 -- us2k15Minor allele frequency- T:0.05NS EA NA 536
    rs1400569641,2
    --43900366(+) CATGGA/GTGTTC 1 -- us2k10--------
    rs1420595231,2
    --43900508(+) CACTGC/TGGGCC 1 -- us2k10--------
    rs357373711,2
    C,F--43900824(+) GGATGC/TCAAGA 1 -- us2k15Minor allele frequency- T:0.01NS 186
    rs343939841,2
    C,F--43900833(+) GACCAT/CTAAGA 1 -- us2k16Minor allele frequency- C:0.02NS WA 304
    rs342418631,2
    C,F--43900864(+) GCATCG/ATCTAG 1 -- us2k16Minor allele frequency- A:0.02NS WA 306
    rs343774101,2
    C,F--43900981(+) CCTACA/GTATGT 1 -- us2k16Minor allele frequency- G:0.02NS WA 300
    rs339987651,2
    C--43900984(+) ACATAT/CGTCCT 1 -- us2k16Minor allele frequency- C:0.01NS WA 300
    rs112888021,2
    C,F--43901062(+) AAAAAA/-GCAGT 1 -- us2k1 trp38Minor allele frequency- -:0.09NA NS 188
    rs349889431,2
    C,F--43901124(+) CACTAC/TGTAGA 1 -- us2k16Minor allele frequency- T:0.02NS WA 300

    HapMap Linkage Disequilibrium report for ALKBH3 (43902357 - 43941825 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for ALKBH3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2028436CNV Deletion18987734
    esv2663316CNV Deletion23128226
    esv2744413CNV Deletion23290073
    esv2616474CNV Deletion19546169
    esv272089CNV Insertion20981092
    esv6093CNV Loss19470904
    nsv832138CNV Gain17160897
    nsv467867CNV Gain19166990

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610603    OMIM disorders: --

    1 disease for ALKBH3:    
    About MalaCards
    prostate cancer

    1 disease from the University of Copenhagen DISEASES database for ALKBH3:
    Mucoepidermoid carcinoma

    Find genes that share disorders with ALKBH3           About GenesLikeMe

    1 Novoseek inferred disease relationship for ALKBH3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prostate cancer 32.5 10 18077911 (2), 17968469 (2), 17970783 (1), 16033822 (1)

    Genetic Association Database (GAD): ALKBH3
    Human Genome Epidemiology (HuGE) Navigator: ALKBH3 (2 documents)

    Export disorders for ALKBH3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ALKBH3 gene, integrated from 10 sources (see all 30):
    (articles sorted by number of sources associating them with ALKBH3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. DNA unwinding by ASCC3 helicase is coupled to ALKBH3-dependent DNA alkylation repair and cancer cell proliferation. (PubMed id 22055184)1, 2, 3 Dango S.... Shi Y. (Mol. Cell 2011)
    2. Human ABH3 structure and key residues for oxidative demethylation to reverse DNA/RNA damage. (PubMed id 16858410)1, 2 Sundheim O.... Slupphaug G. (EMBO J. 2006)
    3. Repair of methylation damage in DNA and RNA by mammalian AlkB homologues. (PubMed id 16174769)1, 2 Lee D.-H.... O'Connor T.R. (J. Biol. Chem. 2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA. (PubMed id 12594517)1, 2 Aas P.A....Krokan H.E. (Nature 2003)
    6. Reversal of DNA alkylation damage by two human dioxygenases. (PubMed id 12486230)1, 2 Duncan T....Sedgwick B. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    7. Prostate cancer antigen-1 as a potential novel marker for prostate cancer. (PubMed id 17968469)1, 9 Liu B.Q....Liu R.L. (Asian J. Androl. 2007)
    8. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    9. PCA-1/ALKBH3 contributes to pancreatic cancer by supporting apoptotic resistance and angiogenesis. (PubMed id 22826605)1 Yamato I....Nakajima Y. (Cancer Res. 2012)
    10. ALKBH3 contributes to survival and angiogenesis of human urothelial carcinoma cells through NADPH oxidase and tweak/Fn14/VEGF signals. (PubMed id 22850567)1 Shimada K....Konishi N. (Clin. Cancer Res. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 221120 HGNC: 30141 AceView: DEPC-1 Ensembl:ENSG00000166199 euGenes: HUgn221120
    ECgene: ALKBH3 H-InvDB: ALKBH3

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ALKBH3 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/depc1/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ALKBH3 gene:
    Search GeneIP for patents involving ALKBH3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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