Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ALKBH2 Gene

Aliases for ALKBH2 Gene

  • AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase 2 3 5
  • Alpha-Ketoglutarate-Dependent Dioxygenase AlkB Homolog 2 3 4
  • Alkylated DNA Repair Protein AlkB Homolog 2 3 4
  • Oxy DC1 3 4
  • ABH2 3 4
  • AlkB, Alkylation Repair Homolog 2 (E. Coli) 2
  • AlkB, Alkylation Repair Homolog 2 3
  • 2OG-Fe(II) Oxy DC1 3
  • EC 1.14.11.33 4

External Ids for ALKBH2 Gene

Previous GeneCards Identifiers for ALKBH2 Gene

  • GC12M108010
  • GC12M109525
  • GC12M106544

Summaries for ALKBH2 Gene

Entrez Gene Summary for ALKBH2 Gene

  • The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA. ALKBH2 and ALKBH3 (MIM 610603) are E. coli AlkB homologs that catalyze the removal of 1-methyladenine and 3-methylcytosine (Duncan et al., 2002 [PubMed 12486230]).[supplied by OMIM, Mar 2008]

GeneCards Summary for ALKBH2 Gene

ALKBH2 (AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase) is a Protein Coding gene. Among its related pathways are DNA Damage Reversal and DNA Double-Strand Break Repair. GO annotations related to this gene include oxidoreductase activity and ferrous iron binding. An important paralog of this gene is ALKBH3.

UniProtKB/Swiss-Prot for ALKBH2 Gene

  • Dioxygenase that repairs alkylated DNA and RNA containing 1-methyladenine and 3-methylcytosine by oxidative demethylation. Can also repair alkylated DNA containing 1-ethenoadenine (in vitro). Has strong preference for double-stranded DNA. Has low efficiency with single-stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ALKBH2 Gene

Genomics for ALKBH2 Gene

Regulatory Elements for ALKBH2 Gene

Enhancers for ALKBH2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ALKBH2 on UCSC Golden Path with GeneCards custom track

Promoters for ALKBH2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ALKBH2 on UCSC Golden Path with GeneCards custom track

Genomic Location for ALKBH2 Gene

Chromosome:
12
Start:
109,088,188 bp from pter
End:
109,093,631 bp from pter
Size:
5,444 bases
Orientation:
Minus strand

Genomic View for ALKBH2 Gene

Genes around ALKBH2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ALKBH2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ALKBH2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ALKBH2 Gene

Proteins for ALKBH2 Gene

  • Protein details for ALKBH2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6NS38-ALKB2_HUMAN
    Recommended name:
    DNA oxidative demethylase ALKBH2
    Protein Accession:
    Q6NS38
    Secondary Accessions:
    • A4PET2
    • Q5XLE3

    Protein attributes for ALKBH2 Gene

    Size:
    261 amino acids
    Molecular mass:
    29322 Da
    Cofactor:
    Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ALKBH2 Gene

    Alternative splice isoforms for ALKBH2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ALKBH2 Gene

Proteomics data for ALKBH2 Gene at MOPED

Post-translational modifications for ALKBH2 Gene

  • Ubiquitination at Lys 104 and Lys 111
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for ALKBH2 Gene

Domains & Families for ALKBH2 Gene

Gene Families for ALKBH2 Gene

Protein Domains for ALKBH2 Gene

Suggested Antigen Peptide Sequences for ALKBH2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6NS38

UniProtKB/Swiss-Prot:

ALKB2_HUMAN :
  • Contains 1 Fe2OG dioxygenase domain.
  • Belongs to the alkB family.
Domain:
  • Contains 1 Fe2OG dioxygenase domain.
Family:
  • Belongs to the alkB family.
genes like me logo Genes that share domains with ALKBH2: view

Function for ALKBH2 Gene

Molecular function for ALKBH2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
DNA-base-CH(3) + 2-oxoglutarate + O(2) = DNA-base + formaldehyde + succinate + CO(2).
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by ascorbate and magnesium ions.
UniProtKB/Swiss-Prot Function:
Dioxygenase that repairs alkylated DNA and RNA containing 1-methyladenine and 3-methylcytosine by oxidative demethylation. Can also repair alkylated DNA containing 1-ethenoadenine (in vitro). Has strong preference for double-stranded DNA. Has low efficiency with single-stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron.

Enzyme Numbers (IUBMB) for ALKBH2 Gene

Gene Ontology (GO) - Molecular Function for ALKBH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008198 ferrous iron binding IDA 18432238
GO:0051747 cytosine C-5 DNA demethylase activity TAS 18775698
genes like me logo Genes that share ontologies with ALKBH2: view
genes like me logo Genes that share phenotypes with ALKBH2: view

Animal Models for ALKBH2 Gene

MGI Knock Outs for ALKBH2:

Animal Model Products

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ALKBH2 Gene

Localization for ALKBH2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ALKBH2 Gene

Nucleus. Note=Detected in replication foci during S-phase.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ALKBH2 Gene COMPARTMENTS Subcellular localization image for ALKBH2 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for ALKBH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015630 microtubule cytoskeleton IDA --
genes like me logo Genes that share ontologies with ALKBH2: view

Pathways & Interactions for ALKBH2 Gene

genes like me logo Genes that share pathways with ALKBH2: view

Interacting Proteins for ALKBH2 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000343021%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000294008%0d%0a9606.ENSP00000368552%0d%0a
Selected Interacting proteins: ENSP00000343021 Q6NS38-ALKB2_HUMAN for ALKBH2 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for ALKBH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035511 oxidative DNA demethylation IDA 18432238
GO:0055114 oxidation-reduction process IEA --
GO:0070989 oxidative demethylation TAS 18775698
genes like me logo Genes that share ontologies with ALKBH2: view

No data available for SIGNOR curated interactions for ALKBH2 Gene

Drugs & Compounds for ALKBH2 Gene

(4) Drugs for ALKBH2 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Vitamin C Approved Nutra Target 471,471
Succinic acid Approved Nutra Full agonist, Agonist 0
2-Ketobutyric acid Experimental Pharma 0
Formaldehyde Experimental Pharma 78

(3) Additional Compounds for ALKBH2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Fe2+
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
15438-31-0
Oxoglutaric acid
  • 2-Ketoglutarate
  • 2-Ketoglutaric acid
  • 2-Oxo-1,5-pentanedioate
  • 2-Oxo-1,5-pentanedioic acid
  • 2-Oxoglutarate
328-50-7
oxygen
  • Dioxygen
  • Molecular oxygen
  • O2
  • Oxygen
  • Oxygen molecule
7782-44-7
genes like me logo Genes that share compounds with ALKBH2: view

Transcripts for ALKBH2 Gene

Unigene Clusters for ALKBH2 Gene

AlkB, alkylation repair homolog 2 (E. coli):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ALKBH2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c ^ 4a · 4b · 4c
SP1: - -
SP2: - - - - -
SP3:
SP4: - - -
SP5:
SP6: -

Relevant External Links for ALKBH2 Gene

GeneLoc Exon Structure for
ALKBH2
ECgene alternative splicing isoforms for
ALKBH2

Expression for ALKBH2 Gene

mRNA expression in normal human tissues for ALKBH2 Gene

Protein differential expression in normal tissues from HIPED for ALKBH2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (58.7) and CD4 Tcells (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for ALKBH2 Gene



SOURCE GeneReport for Unigene cluster for ALKBH2 Gene Hs.374458

mRNA Expression by UniProt/SwissProt for ALKBH2 Gene

Q6NS38-ALKB2_HUMAN
Tissue specificity: Detected in colon, small intestine, ovary, testis, prostate, skeletal muscle, heart, liver and urinary bladder.
genes like me logo Genes that share expression patterns with ALKBH2: view

Protein tissue co-expression partners for ALKBH2 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ALKBH2 Gene

Orthologs for ALKBH2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ALKBH2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ALKBH2 35
  • 84.36 (n)
  • 84.62 (a)
ALKBH2 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ALKBH2 35
  • 83.01 (n)
  • 82.24 (a)
ALKBH2 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Alkbh2 35
  • 79.15 (n)
  • 84.26 (a)
Alkbh2 16
Alkbh2 36
  • 79 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ALKBH2 35
  • 99.62 (n)
  • 100 (a)
ALKBH2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Alkbh2 35
  • 79.78 (n)
  • 82.01 (a)
oppossum
(Monodelphis domestica)
Mammalia ALKBH2 36
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ALKBH2 36
  • 60 (a)
OneToOne
chicken
(Gallus gallus)
Aves ALKBH2 35
  • 67.09 (n)
  • 68.2 (a)
ALKBH2 36
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia alkbh2 35
  • 60.24 (n)
  • 60.63 (a)
Str.1974 35
zebrafish
(Danio rerio)
Actinopterygii alkbh2 35
  • 59.14 (n)
  • 58.06 (a)
alkbh2 36
  • 54 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 26 (a)
OneToMany
Species with no ortholog for ALKBH2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ALKBH2 Gene

ENSEMBL:
Gene Tree for ALKBH2 (if available)
TreeFam:
Gene Tree for ALKBH2 (if available)

Paralogs for ALKBH2 Gene

Paralogs for ALKBH2 Gene

genes like me logo Genes that share paralogs with ALKBH2: view

Variants for ALKBH2 Gene

Sequence variations from dbSNP and Humsavar for ALKBH2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
VAR_048223 -
rs2078012 -- 109,090,464(+) cctgt(A/G)tcacc intron-variant
rs7300609 -- 109,094,142(+) gcaca(A/T)cccac upstream-variant-2KB
rs34360873 -- 109,091,692(+) CCACT(-/A)ACGCA intron-variant
rs34369408 -- 109,093,528(+) GCAGG(-/C)TAGGG upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for ALKBH2 Gene

Variant ID Type Subtype PubMed ID
esv2422361 CNV Duplication 17116639

Variation tolerance for ALKBH2 Gene

Residual Variation Intolerance Score: 80% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.61; 45.17% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ALKBH2 Gene

Disorders for ALKBH2 Gene

Relevant External Links for ALKBH2

Genetic Association Database (GAD)
ALKBH2
Human Genome Epidemiology (HuGE) Navigator
ALKBH2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ALKBH2

No disorders were found for ALKBH2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ALKBH2 Gene

Publications for ALKBH2 Gene

  1. Crystal structures of DNA/RNA repair enzymes AlkB and ABH2 bound to dsDNA. (PMID: 18432238) Yang C.G. … He C. (Nature 2008) 3 4 67
  2. Drugs, their targets and the nature and number of drug targets. (PMID: 17016423) Imming P. … Meyer A. (Nat Rev Drug Discov 2006) 25 26
  3. How many drug targets are there? (PMID: 17139284) Overington J.P. … Hopkins A.L. (Nat Rev Drug Discov 2006) 25 26
  4. Differential repair of etheno-DNA adducts by bacterial and human AlkB proteins. (PMID: 25797601) ZdA1alik D. … Tudek B. (DNA Repair (Amst.) 2015) 3
  5. Noncanonical regulation of alkylation damage resistance by the OTUD4 deubiquitinase. (PMID: 25944111) Zhao Y. … Mosammaparast N. (EMBO J. 2015) 3

Products for ALKBH2 Gene

Sources for ALKBH2 Gene

Content