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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ALKBH2 Gene

protein-coding   GIFtS: 55
GCID: GC12M109525

alkB, alkylation repair homolog 2 (E. coli)
 Explore 5 diseases affiliated with
ALKBH2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ALKBH2    

Aliases
for ALKBH2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
AlkB, Alkylation Repair Homolog 2 (E. Coli)1 2     MGC905121
ABH21 2 3 5     2OG-Fe(II) Oxy DC12
Alkylated DNA Repair Protein AlkB Homolog 22 3     Alpha-Ketoglutarate-Dependent Dioxygenase AlkB Homolog 22
Oxy DC12 3     EC 1.14.11.333
DNA Oxidative Demethylase ALKBH22 3     

External Ids:    HGNC: 324871   Entrez Gene: 1216422   Ensembl: ENSG000001890467   OMIM: 6106025   UniProtKB: Q6NS383   

Export aliases for ALKBH2 gene to outside databases

Previous GC identifers: GC12M108010 GC12M106544


Summaries
for ALKBH2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ALKBH2:
The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA
lesions generated in single-stranded DNA. ALKBH2 and ALKBH3 (MIM 610603) are E. coli AlkB homologs that catalyze the
removal of 1-methyladenine and 3-methylcytosine (Duncan et al., 2002 (PubMed 12486230)).(supplied by OMIM, Mar 2008)

UniProtKB/Swiss-Prot: ALKB2_HUMAN, Q6NS38
Function: Dioxygenase that repairs alkylated DNA and RNA containing 1-methyladenine and 3-methylcytosine by oxidative
demethylation. Can also repair alkylated DNA containing 1-ethenoadenine (in vitro). Has strong preference for
double-stranded DNA. Has low efficiency with single-stranded substrates. Requires molecular oxygen,
alpha-ketoglutarate and iron




Genomic Views
for ALKBH2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_009775.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ALKBH2 gene promoter:
         AML1a   Egr-1   AP-2gamma   Arnt   HEN1   AP-2beta   AP-2alpha   NF-Y   AP-2alphaA   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ALKBH2 promoter sequence
   Search SABiosciences Chromatin IP Primers for ALKBH2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ALKBH2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.11   Ensembl cytogenetic band:  12q24.11   HGNC cytogenetic band: 12q24.11

ALKBH2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ALKBH2 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M109525:  view genomic region     (about GC identifiers)

Start:
 109,525,993 bp from pter      End:
 109,531,436 bp from pter
Size:
 5,444 bases      Orientation:
 minus strand

Proteins
for ALKBH2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ALKB2_HUMAN, Q6NS38 (See protein sequence)
Recommended Name: Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2  
Size: 261 amino acids; 29322 Da
Cofactor: Binds 1 Fe(2+) ion per subunit
Subcellular location: Nucleus. Note=Detected in replication foci during S-phase
6/16 PDB 3D structures from and Proteopedia for ALKBH2 (see all 16):
3BTX (3D)        3BTY (3D)        3BTZ (3D)        3BU0 (3D)        3BUC (3D)        3H8O (3D)    
Secondary accessions: A4PET2 Q5XLE3
Alternative splicing: 2 isoforms:  Q6NS38-1   Q6NS38-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ALKBH2: NX_Q6NS38

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q6NS38

    • ALKBH2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (5 alternative transcripts): 
    NP_001001655.1  NP_001138846.1  NP_001138847.1  NP_001192108.1  NP_001192109.1  

    ENSEMBL proteins: 
     ENSP00000343021   ENSP00000398509   ENSP00000399820   ENSP00000443181   ENSP00000443042  
     ENSP00000444103   ENSP00000398181  
    Reactome Protein details: Q6NS38
    Human Recombinant Protein Products: 
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    OriGene Purified Proteins (see all 3): ALKBH2
    OriGene Protein Over-expression Lysate (see all 3): ALKBH2
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    Novus Biologicals ALKBH2 Proteins
    Novus Biologicals ALKBH2 Lysates
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    ProSpec Recombinant Protein for ALKBH2
    Uscn Proteins for ALKBH2

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--


    ALKBH2 for ontologies           About GeneDecksing



    ALKBH2 Antibody Products: 
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    Uscn ELISAs and CLIAs for ALKBH2

    Protein Domains /
    Families
    for ALKBH2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ALKBH2 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR005123 Oxoglu/Fe-dep_dioxygenase

    Graphical View of Domain Structure for InterPro Entry Q6NS38

    ProtoNet protein and cluster: Q6NS38

    UniProtKB/Swiss-Prot: ALKB2_HUMAN, Q6NS38
    Similarity: Belongs to the alkB family
    Similarity: Contains 1 Fe2OG dioxygenase domain


    Function
    for ALKBH2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ALKB2_HUMAN, Q6NS38
    Function: Dioxygenase that repairs alkylated DNA and RNA containing 1-methyladenine and 3-methylcytosine by oxidative
    demethylation. Can also repair alkylated DNA containing 1-ethenoadenine (in vitro). Has strong preference for
    double-stranded DNA. Has low efficiency with single-stranded substrates. Requires molecular oxygen,
    alpha-ketoglutarate and iron
    Catalytic activity: DNA-base-CH(3) + 2-oxoglutarate + O(2) = DNA-base + formaldehyde + succinate + CO(2)
    Enzyme regulation: Activated by ascorbate and magnesium ions

    Enzyme Number (IUBMB): EC 1.14.11.331

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    Inhib. RNA
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    OriGene shRNA RFP: ALKBH2
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    Gene Editing
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    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for ALKBH2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALKBH2

    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008198ferrous iron binding IDA18432238
    GO:0016702oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen IEA--
    GO:0016706oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors ----
    GO:0043734DNA-N1-methyladenine dioxygenase activity IDA18432238
    GO:0051747cytosine C-5 DNA demethylase activity TAS18775698


    ALKBH2 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for ALKBH2:
     Increased number of cells in m 

    Animal Models:
         Mouse knock-out Alkbh2tm1Klng for ALKBH2
         3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Alkbh2):
     cellular  homeostasis/metabolism  mortality/aging 

    ALKBH2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for ALKBH2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Reversal of Alkylation Damage By DNA Dioxygenases
    		Reversal of Alkylation Damage By DNA Dioxygenases1.00
    		ABH2 mediated Reversal of Alkylation Damage0.50
    		DNA Damage Reversal0.67
    2Nucleotide Excision Repair
    		DNA Repair0.46

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    4        Reactome Pathways for ALKBH2
        Reversal of Alkylation Damage By DNA Dioxygenases
    DNA Repair
    DNA Damage Reversal
    ABH2 mediated Reversal of Alkylation Damage



    ALKBH2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ALKBH2

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for ALKBH2 (Q6NS383 ENSP000003430214) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SLX4Q8IY923, ENSP000002940084I2D: score=1 STRING: ENSP00000294008
    SIRT5ENSP000003685524STRING: ENSP00000368552
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006281DNA repair TAS--
    GO:0006307DNA dealkylation involved in DNA repair TAS18775698
    GO:0035511oxidative DNA demethylation IDA18432238
    GO:0070989oxidative demethylation TAS18775698
    GO:0080111DNA demethylation TAS18775698


    ALKBH2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ALKBH2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ALKBH2

    2 HMDB Compounds for ALKBH2    About this table
    CompoundSynonyms CAS #PubMed Ids
    2-Ketobutyric acid2-Ketobutanoate (see all 35)600-18-0--
    IronArmco iron (see all 19)7439-89-6--

    1 DrugBank Compound for ALKBH2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Vitamin CAscorbate (see all 6)50-81-7target--17139284 17016423

    Search CenterWatch for drugs/clinical trials and news about ALKBH2 / ALKB2 

    Transcripts
    for ALKBH2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ALKBH2 gene (5 alternative transcripts): 
    NM_001001655.2  NM_001145374.1  NM_001145375.1  NM_001205179.1  NM_001205180.1  

    Unigene Cluster for ALKBH2:

    AlkB, alkylation repair homolog 2 (E. coli)
    Hs.374458  [show with all ESTs]
    Unigene Representative Sequence: BE620550
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000343075 ENST00000435370 ENST00000440112 ENST00000543444 ENST00000540305
    ENST00000536242 ENST00000536358 ENST00000536720 ENST00000429722(uc001tnx.2 uc001tny.2 uc010sxj.1 uc009zvd.2 uc010sxk.1)


    miRNA
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    Inhib. RNA
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    OriGene shRNA RFP: ALKBH2
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    Clone
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ALKBH2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ALKBH2

    Additional cDNA sequence: 

    AB277859.1 AY754389.1 BC070489.1 

    13 DOTS entries:

    DT.100892179  DT.102825182  DT.95173725  DT.95173722  DT.75104082  DT.92427543  DT.95173724  DT.100808780 
    DT.92427540  DT.121194094  DT.95102229  DT.100892182  DT.91648997 

    24/136 AceView cDNA sequences (see all 136):

    CB115208 AI078333 BU535633 AI269764 BC070489 CR597009 BU542852 BM820131 
    AI421482 CD365196 BM785502 BM852409 BQ013942 BQ920902 BM701520 BE328465 
    AW246209 CR623288 AW206726 AI128560 CF529681 CR601252 BE208449 BM713799 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ALKBH2 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c ^ 4a · 4b · 4c
    SP1:                          -     -                                                   
    SP2:                          -     -                 -     -     -                     
    SP3:                                                                                    
    SP4:                    -     -     -                                                   
    SP5:                                                                                    


    ECgene alternative splicing isoforms for ALKBH2

    Expression
    for ALKBH2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ALKBH2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTTTTAAACT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See ALKBH2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ALKBH2

    SOURCE GeneReport for Unigene cluster: Hs.374458

    UniProtKB/Swiss-Prot: ALKB2_HUMAN, Q6NS38
    Tissue specificity: Detected in colon, small intestine, ovary, testis, prostate, skeletal muscle, heart, liver and
    urinary bladder

        SABiosciences Custom PCR Arrays for ALKBH2
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    In Situ
    Assay Products:     
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    Orthologs
    for ALKBH2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ALKBH2 gene from 6/16 species (see all 16)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Alkbh21 , 5 alkB, alkylation repair homolog 2 (E. coli)1, 5 79.43(n)1
    84.26(a)1    		   5 (55.97 cM)5
    2316421  NM_175016.21  NP_778181.21 
     1141239265 
    chicken
    (Gallus gallus)    		 Aves ALKBH21 alkB, alkylation repair homolog 2 (E. coli) 66.81(n)
    67.36(a)    		   416897  XM_003642183.1  XP_003642231.1 
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.19742 Transcribed sequence with weak similarity to protein more 75.28(n)    BX760501.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii alkbh21 alkB, alkylation repair homolog 2 (E. coli) 58.96(n)
    57.77(a)    		   569291  XM_692669.4  XP_697761.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT2G222606
    		 oxidoreductase, 2OG-Fe(II) oxygenase-like protein
    		 25(a)
    		 1 → many
    		 2(9461125-9463192)
    rice
    (Oryza sativa)    		 Liliopsida --
    		 oxidoreductase, 2OG-Fe oxygenase family protein, p...
    		 29(a)
    		 1 → many
    		 6(10340178-10342173)


    ENSEMBL Gene Tree for ALKBH2 (if available)
    TreeFam Gene Tree for ALKBH2 (if available) 

    Paralogs
    for ALKBH2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ALKBH2 gene
    ALKBH32  

    ALKBH2 for paralogs           About GeneDecksing



    Genomic Variants
    for ALKBH2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/146 NCBI SNPs in ALKBH2 are shown (see all 146)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1815896951,2
    		--109526395(+) TTTTCC/TTCACA 5 -- int10--------
    rs1858564431,2
    		--109526421(+) CTGCAG/TGGCTG 5 -- int10--------
    rs1148046581,2
    		F,--109526551(+) GTCTCG/ACTCTG 5 -- int11Minor allele frequency- A:0.02WA 118
    rs1437072961,2
    		--109526601(+) TGCAGC/TCTCGG 5 -- int10--------
    rs1467730881,2
    		--109526605(+) GCCTCA/GGCCTC 5 -- int10--------
    rs1404584691,2
    		--109526642(+) AGCCTC/GCCAAG 5 -- int10--------
    rs110690311,2
    		C,F,A,--109526754(+) AAGCAC/ATTCAC 5 -- int16Minor allele frequency- A:0.43NA WA EA 364
    rs110690421,2
    		C,F,A,H,--109526808(+) CCACGC/TCCGGC 5 -- int120Minor allele frequency- T:0.25NS EA WA NA 2346
    rs110690461,2
    		C,F,H,--109526858(+) AATCAC/TGTCTT 5 -- int18Minor allele frequency- T:0.03NS EA NA 928
    rs1454273251,2
    		--109526859(+) ATCACA/GTCTTA 5 -- int10--------

    HapMap Linkage Disequilibrium report for ALKBH2 (109525993 - 109531436 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for ALKBH2
         1 CNV: 5312

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    Disorders / Diseases
    for ALKBH2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ALKBH2 for disorders           About GeneDecksing

    OMIM gene information: 610602    OMIM disorders: --

    5 diseases for ALKBH2:    About MalaCards
    gastric cancer    meningioma    tuberculosis    prostatitis
    mycobacterium tuberculosis

    Human Genome Epidemiology (HuGE) Navigator: ALKBH2 (2 documents)

    Export disorders for ALKBH2 gene to outside databases

    Publications
    for ALKBH2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ALKBH2 gene, integrated from 9 sources (see all 32):
    (articles sorted by number of sources associating them with ALKBH2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Crystal structures of DNA/RNA repair enzymes AlkB and ABH2 bound to dsDNA. (PubMed id 18432238)1, 2 Yang C.G....He C. (2008)
    2. AlkB homologue 2-mediated repair of ethenoadenine lesions in mammalian DNA. (PubMed id 18519673)1, 2 Ringvoll J....Klungland A. (2008)
    3. Repair of methylation damage in DNA and RNA by mammalian AlkB homologues. (PubMed id 16174769)1, 2 Lee D.-H.... O'Connor T.R. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA. (PubMed id 12594517)1, 2 Aas P.A....Krokan H.E. (2003)
    6. Reversal of DNA alkylation damage by two human dioxygenases. (PubMed id 12486230)1, 2 Duncan T....Sedgwick B. (2002)
    7. Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)
    8. Duplex interrogation by a direct DNA repair protein in search of base damage. (PubMed id 22659876)1 Yi C....He C. (2012)
    9. Direct repair of 3,N(4)-ethenocytosine by the human AL KBH2 dioxygenase is blocked by the AAG/MPG glycosylase. (PubMed id 22079122)1 Fu D. and Samson L.D. (2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)

    External Searches for ALKBH2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
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    Genome Databases showing ALKBH2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 121642 HGNC: 32487 AceView: MGC90512 Ensembl:ENSG00000189046 euGenes: HUgn121642
    ECgene: ALKBH2 H-InvDB: ALKBH2

    Other Databases showing ALKBH2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ALKBH2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ALKBH2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ALKBH2 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for ALKBH2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ALKBH2 gene:
    Search GeneIP for patents involving ALKBH2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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