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Aliases for ALKBH2 Gene

Aliases for ALKBH2 Gene

  • AlkB, Alkylation Repair Homolog 2 (E. Coli) 2 3
  • ABH2 3 4 6
  • Alkylated DNA Repair Protein AlkB Homolog 2 3 4
  • DNA Oxidative Demethylase ALKBH2 3 4
  • Oxy DC1 3 4
  • Alpha-Ketoglutarate-Dependent Dioxygenase AlkB Homolog 2 3
  • 2OG-Fe(II) Oxy DC1 3
  • EC 1.14.11.33 4

External Ids for ALKBH2 Gene

Previous GeneCards Identifiers for ALKBH2 Gene

  • GC12M108010
  • GC12M109525
  • GC12M106544

Summaries for ALKBH2 Gene

Entrez Gene Summary for ALKBH2 Gene

  • The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA. ALKBH2 and ALKBH3 (MIM 610603) are E. coli AlkB homologs that catalyze the removal of 1-methyladenine and 3-methylcytosine (Duncan et al., 2002 [PubMed 12486230]).[supplied by OMIM, Mar 2008]

GeneCards Summary for ALKBH2 Gene

ALKBH2 (AlkB, Alkylation Repair Homolog 2 (E. Coli)) is a Protein Coding gene. Among its related pathways are DNA Repair and DNA Repair. GO annotations related to this gene include ferrous iron binding and cytosine C-5 DNA demethylase activity. An important paralog of this gene is ALKBH3.

UniProtKB/Swiss-Prot for ALKBH2 Gene

  • Dioxygenase that repairs alkylated DNA and RNA containing 1-methyladenine and 3-methylcytosine by oxidative demethylation. Can also repair alkylated DNA containing 1-ethenoadenine (in vitro). Has strong preference for double-stranded DNA. Has low efficiency with single-stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ALKBH2 Gene

Genomics for ALKBH2 Gene

Regulatory Elements for ALKBH2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ALKBH2 Gene

Start:
109,088,188 bp from pter
End:
109,093,631 bp from pter
Size:
5,444 bases
Orientation:
Minus strand

Genomic View for ALKBH2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ALKBH2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ALKBH2 Gene

Proteins for ALKBH2 Gene

  • Protein details for ALKBH2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6NS38-ALKB2_HUMAN
    Recommended name:
    Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2
    Protein Accession:
    Q6NS38
    Secondary Accessions:
    • A4PET2
    • Q5XLE3

    Protein attributes for ALKBH2 Gene

    Size:
    261 amino acids
    Molecular mass:
    29322 Da
    Cofactor:
    Name=Fe(2+); Xref=ChEBI:CHEBI:29033; Note=Binds 1 Fe(2+) ion per subunit.;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ALKBH2 Gene

    Alternative splice isoforms for ALKBH2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ALKBH2 Gene

Proteomics data for ALKBH2 Gene at MOPED

Post-translational modifications for ALKBH2 Gene

  • Ubiquitination at Lys104 and Lys111
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ALKBH2 Gene

Domains for ALKBH2 Gene

Gene Families for ALKBH2 Gene

HGNC:
  • ALKB :Alkylation repair homologs

Protein Domains for ALKBH2 Gene

Suggested Antigen Peptide Sequences for ALKBH2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6NS38

UniProtKB/Swiss-Prot:

ALKB2_HUMAN :
  • Q6NS38
Domain:
  • Contains 1 Fe2OG dioxygenase domain.
Family:
  • Belongs to the alkB family.
genes like me logo Genes that share domains with ALKBH2: view

Function for ALKBH2 Gene

Molecular function for ALKBH2 Gene

UniProtKB/Swiss-Prot CatalyticActivity: DNA-base-CH(3) + 2-oxoglutarate + O(2) = DNA-base + formaldehyde + succinate + CO(2)
UniProtKB/Swiss-Prot EnzymeRegulation: Activated by ascorbate and magnesium ions.
UniProtKB/Swiss-Prot Function: Dioxygenase that repairs alkylated DNA and RNA containing 1-methyladenine and 3-methylcytosine by oxidative demethylation. Can also repair alkylated DNA containing 1-ethenoadenine (in vitro). Has strong preference for double-stranded DNA. Has low efficiency with single-stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron.

Enzyme Numbers (IUBMB) for ALKBH2 Gene

Gene Ontology (GO) - Molecular Function for ALKBH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008198 ferrous iron binding IDA 18432238
GO:0016491 oxidoreductase activity --
GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors --
GO:0043734 DNA-N1-methyladenine dioxygenase activity IDA 18432238
GO:0051747 cytosine C-5 DNA demethylase activity TAS 18775698
genes like me logo Genes that share ontologies with ALKBH2: view
genes like me logo Genes that share phenotypes with ALKBH2: view

Animal Models for ALKBH2 Gene

MGI Knock Outs for ALKBH2:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ALKBH2

In Situ Assay Products

Flow Cytometry Products

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for ALKBH2 Gene

Localization for ALKBH2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ALKBH2 Gene

Nucleus. Note=Detected in replication foci during S-phase.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ALKBH2 Gene COMPARTMENTS Subcellular localization image for ALKBH2 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ALKBH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0015630 microtubule cytoskeleton IDA --
genes like me logo Genes that share ontologies with ALKBH2: view

Pathways for ALKBH2 Gene

genes like me logo Genes that share pathways with ALKBH2: view

Interacting Proteins for ALKBH2 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000343021%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000294008%0d%0a9606.ENSP00000368552%0d%0a
Selected Interacting proteins: ENSP00000343021 Q6NS38-ALKB2_HUMAN for ALKBH2 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for ALKBH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair TAS --
GO:0006307 DNA dealkylation involved in DNA repair TAS 18775698
GO:0035511 oxidative DNA demethylation IDA 18432238
GO:0055114 oxidation-reduction process --
GO:0070989 oxidative demethylation TAS 18775698
genes like me logo Genes that share ontologies with ALKBH2: view

Compounds for ALKBH2 Gene

(2) HMDB Compounds for ALKBH2 Gene

Compound Synonyms Cas Number PubMed IDs
2-Ketobutyric acid
  • 2-Ketobutanoate
600-18-0
Iron
  • Armco iron
7439-89-6

(1) Drugbank Compounds for ALKBH2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Vitamin C
  • Ascorbate
50-81-7 target
genes like me logo Genes that share compounds with ALKBH2: view

Transcripts for ALKBH2 Gene

Unigene Clusters for ALKBH2 Gene

AlkB, alkylation repair homolog 2 (E. coli):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ALKBH2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ALKBH2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c ^ 4a · 4b · 4c
SP1: - -
SP2: - - - - -
SP3:
SP4: - - -
SP5:
SP6: -

Relevant External Links for ALKBH2 Gene

GeneLoc Exon Structure for
ALKBH2
ECgene alternative splicing isoforms for
ALKBH2

Expression for ALKBH2 Gene

mRNA expression in normal human tissues for ALKBH2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ALKBH2 Gene

SOURCE GeneReport for Unigene cluster for ALKBH2 Gene Hs.374458

mRNA Expression by UniProt/SwissProt for ALKBH2 Gene

Q6NS38-ALKB2_HUMAN
Tissue specificity: Detected in colon, small intestine, ovary, testis, prostate, skeletal muscle, heart, liver and urinary bladder.
genes like me logo Genes that share expressions with ALKBH2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ALKBH2 Gene

Orthologs for ALKBH2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ALKBH2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ALKBH2 35
  • 99.62 (n)
  • 100 (a)
ALKBH2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ALKBH2 35
  • 84.36 (n)
  • 84.62 (a)
ALKBH2 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ALKBH2 35
  • 83.01 (n)
  • 82.24 (a)
ALKBH2 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Alkbh2 35
  • 79.15 (n)
  • 84.26 (a)
Alkbh2 16
Alkbh2 36
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ALKBH2 36
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ALKBH2 36
  • 60 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Alkbh2 35
  • 79.78 (n)
  • 82.01 (a)
chicken
(Gallus gallus)
Aves ALKBH2 35
  • 67.09 (n)
  • 68.2 (a)
ALKBH2 36
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia alkbh2 35
  • 60.24 (n)
  • 60.63 (a)
Str.1974 35
zebrafish
(Danio rerio)
Actinopterygii alkbh2 35
  • 59.14 (n)
  • 58.06 (a)
alkbh2 36
  • 54 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 26 (a)
OneToMany
Species with no ortholog for ALKBH2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ALKBH2 Gene

ENSEMBL:
Gene Tree for ALKBH2 (if available)
TreeFam:
Gene Tree for ALKBH2 (if available)

Paralogs for ALKBH2 Gene

Paralogs for ALKBH2 Gene

genes like me logo Genes that share paralogs with ALKBH2: view

Variants for ALKBH2 Gene

Sequence variations from dbSNP and Humsavar for ALKBH2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs1623845 -- 109,093,559(-) ACCAG(A/G)GGGCC upstream-variant-2KB, utr-variant-5-prime
rs1642029 -- 109,094,789(+) ACACT(C/G)AGGCC upstream-variant-2KB
rs1642030 -- 109,095,262(+) tgagc(C/T)gctgt upstream-variant-2KB
rs1642042 -- 109,093,860(+) aagtg(C/G)ggact upstream-variant-2KB
rs1654891 -- 109,094,749(-) TAAAG(A/C)CACCA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ALKBH2 Gene

Variant ID Type Subtype PubMed ID
esv2422361 CNV Duplication 17116639

Relevant External Links for ALKBH2 Gene

HapMap Linkage Disequilibrium report
ALKBH2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ALKBH2 Gene

Disorders for ALKBH2 Gene

(1) University of Copenhagen DISEASES for ALKBH2 Gene

Relevant External Links for ALKBH2

Genetic Association Database (GAD)
ALKBH2
Human Genome Epidemiology (HuGE) Navigator
ALKBH2
genes like me logo Genes that share disorders with ALKBH2: view

No data available for UniProtKB/Swiss-Prot for ALKBH2 Gene

Publications for ALKBH2 Gene

  1. Crystal structures of DNA/RNA repair enzymes AlkB and ABH2 bound to dsDNA. (PMID: 18432238) Yang C.G. … He C. (Nature 2008) 3 4
  2. AlkB homologue 2-mediated repair of ethenoadenine lesions in mammalian DNA. (PMID: 18519673) Ringvoll J. … Klungland A. (Cancer Res. 2008) 3 4
  3. Reversal of DNA alkylation damage by two human dioxygenases. (PMID: 12486230) Duncan T. … Sedgwick B. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 4
  4. Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA. (PMID: 12594517) Aas P.A. … Krokan H.E. (Nature 2003) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for ALKBH2 Gene

Sources for ALKBH2 Gene

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