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ALKBH2 Gene

protein-coding   GIFtS: 58
GCID: GC12M109525

AlkB, Alkylation Repair Homolog 2 (E. Coli)

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
AlkB, Alkylation Repair Homolog 2 (E. Coli)1 2     DNA Oxidative Demethylase ALKBH22 3
ABH22 3 5     2OG-Fe(II) Oxy DC12
Alkylated DNA Repair Protein AlkB Homolog 22 3     Alpha-Ketoglutarate-Dependent Dioxygenase AlkB Homolog 22
Oxy DC12 3     EC 1.14.11.333

External Ids:    HGNC: 324871   Entrez Gene: 1216422   Ensembl: ENSG000001890467   OMIM: 6106025   UniProtKB: Q6NS383   

Export aliases for ALKBH2 gene to outside databases

Previous GC identifers: GC12M108010 GC12M106544


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ALKBH2 Gene:
The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the
specific DNA lesions generated in single-stranded DNA. ALKBH2 and ALKBH3 (MIM 610603) are E. coli AlkB homologs
that catalyze the removal of 1-methyladenine and 3-methylcytosine (Duncan et al., 2002 (PubMed
12486230)).(supplied by OMIM, Mar 2008)

GeneCards Summary for ALKBH2 Gene:
ALKBH2 (alkB, alkylation repair homolog 2 (E. coli)) is a protein-coding gene. GO annotations related to this gene include cytosine C-5 DNA demethylase activity and ferrous iron binding. An important paralog of this gene is ALKBH3.

UniProtKB/Swiss-Prot: ALKB2_HUMAN, Q6NS38
Function: Dioxygenase that repairs alkylated DNA and RNA containing 1-methyladenine and 3-methylcytosine by
oxidative demethylation. Can also repair alkylated DNA containing 1-ethenoadenine (in vitro). Has strong
preference for double-stranded DNA. Has low efficiency with single-stranded substrates. Requires molecular
oxygen, alpha-ketoglutarate and iron




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ALKBH2 gene promoter:
         AML1a   Egr-1   AP-2gamma   Arnt   HEN1   AP-2beta   AP-2alpha   NF-Y   AP-2alphaA   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidALKBH2 promoter sequence
   Search Chromatin IP Primers for ALKBH2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ALKBH2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.11   Ensembl cytogenetic band:  12q24.11   HGNC cytogenetic band: 12q24.11

ALKBH2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ALKBH2 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M109525:  view genomic region     (about GC identifiers)

Start:
109,525,993 bp from pter      End:
109,531,436 bp from pter
Size:
5,444 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ALKB2_HUMAN, Q6NS38 (See protein sequence)
Recommended Name: Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2  
Size: 261 amino acids; 29322 Da
Cofactor: Binds 1 Fe(2+) ion per subunit
Selected PDB 3D structures from and Proteopedia for ALKBH2 (see all 16):
3BTX (3D)        3BTY (3D)        3BTZ (3D)        3BU0 (3D)        3BUC (3D)        3H8O (3D)    
Secondary accessions: A4PET2 Q5XLE3
Alternative splicing: 2 isoforms:  Q6NS38-1   Q6NS38-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ALKBH2: NX_Q6NS38

Explore proteomics data for ALKBH2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys104, Lys111
  • Modification sites at PhosphoSitePlus

  • See ALKBH2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001001655.1  NP_001138846.1  NP_001138847.1  NP_001192108.1  NP_001192109.1  

    ENSEMBL proteins: 
     ENSP00000343021   ENSP00000398181   ENSP00000399820   ENSP00000474702   ENSP00000443042  
     ENSP00000444103  
    Reactome Protein details: Q6NS38

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    antibodies-online proteins for ALKBH2 (11 products) 

     
    antibodies-online peptides for ALKBH2

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ALKB: Alkylation repair homologs

    2 InterPro protein domains:
     IPR027450 AlkB-like
     IPR005123 Oxoglu/Fe-dep_dioxygenase

    Graphical View of Domain Structure for InterPro Entry Q6NS38

    ProtoNet protein and cluster: Q6NS38

    UniProtKB/Swiss-Prot: ALKB2_HUMAN, Q6NS38
    Similarity: Belongs to the alkB family
    Similarity: Contains 1 Fe2OG dioxygenase domain


    Find genes that share domains with ALKBH2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ALKB2_HUMAN, Q6NS38
    Function: Dioxygenase that repairs alkylated DNA and RNA containing 1-methyladenine and 3-methylcytosine by
    oxidative demethylation. Can also repair alkylated DNA containing 1-ethenoadenine (in vitro). Has strong
    preference for double-stranded DNA. Has low efficiency with single-stranded substrates. Requires molecular
    oxygen, alpha-ketoglutarate and iron
    Catalytic activity: DNA-base-CH(3) + 2-oxoglutarate + O(2) = DNA-base + formaldehyde + succinate + CO(2)
    Enzyme regulation: Activated by ascorbate and magnesium ions

         Enzyme Number (IUBMB): EC 1.14.11.331

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008198ferrous iron binding IDA18432238
    GO:0016491oxidoreductase activity ----
    GO:0016706oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors ----
    GO:0043734DNA-N1-methyladenine dioxygenase activity IDA18432238
    GO:0051747cytosine C-5 DNA demethylase activity TAS18775698
         
    Find genes that share ontologies with ALKBH2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ALKBH2:
     Increased number of cells in m 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Alkbh2):
     cellular  homeostasis/metabolism  mortality/aging 

    Find genes that share phenotypes with ALKBH2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Alkbh2tm1Klng for ALKBH2

       genOway: Develop your customized and physiologically relevant rodent model for ALKBH2

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ALKB2_HUMAN, Q6NS38: Nucleus. Note=Detected in replication foci during S-phase
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005654nucleoplasm TAS--

    Find genes that share ontologies with ALKBH2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ALKBH2 About    
    See pathways by source

    SuperPathContained pathways About
    1DNA Repair
    DNA Repair0.45
    ABH2 mediated Reversal of Alkylation Damage0.00
    DNA Damage Reversal0.00
    Reversal of Alkylation Damage By DNA Dioxygenases0.00


    Find genes that share SuperPaths with ALKBH2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for ALKBH2
        ABH2 mediated Reversal of Alkylation Damage


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ALKBH2
    Interactions:

        Search GeneGlobe Interaction Network for ALKBH2

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for ALKBH2 (Q6NS383 ENSP000003430214) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SLX4Q8IY923, ENSP000002940084I2D: score=1 STRING: ENSP00000294008
    SIRT5ENSP000003685524STRING: ENSP00000368552
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006281DNA repair TAS--
    GO:0006307DNA dealkylation involved in DNA repair TAS18775698
    GO:0035511oxidative DNA demethylation IDA18432238
    GO:0055114oxidation-reduction process ----
    GO:0070989oxidative demethylation TAS18775698

    Find genes that share ontologies with ALKBH2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for ALKBH2 (ALKB2)

    2 HMDB Compounds for ALKBH2    About this table
    CompoundSynonyms CAS #PubMed Ids
    2-Ketobutyric acid2-Ketobutanoate (see all 35)600-18-0--
    IronArmco iron (see all 19)7439-89-6--

    1 DrugBank Compound for ALKBH2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Vitamin CAscorbate (see all 6)50-81-7target--17139284 17016423



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ALKBH2 gene (5 alternative transcripts): 
    NM_001001655.2  NM_001145374.1  NM_001145375.1  NM_001205179.1  NM_001205180.1  

    Unigene Cluster for ALKBH2:

    AlkB, alkylation repair homolog 2 (E. coli)
    Hs.374458  [show with all ESTs]
    Unigene Representative Sequence: BE620550
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000343075 ENST00000429722(uc001tnx.2 uc001tny.2 uc010sxj.1 uc009zvd.2 uc010sxk.1)
    ENST00000440112 ENST00000543444 ENST00000536242 ENST00000536358 ENST00000536720

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    Additional mRNA sequence: 

    AB277859.1 AY754389.1 BC070489.1 

    13 DOTS entries:

    DT.100892179  DT.95173725  DT.102825182  DT.95173722  DT.75104082  DT.92427543  DT.95173724  DT.100808780 
    DT.92427540  DT.121194094  DT.95102229  DT.100892182  DT.91648997 

    Selected AceView cDNA sequences (see all 136):

    BU542852 CR601252 BC070489 BM701520 CF529681 BQ013942 AI421482 BM820131 
    BM713799 AI417338 CB115208 AW206726 AI269764 BE208449 BM785502 CR597009 
    AW246209 BU535633 CR623288 BM852409 BE328465 NM_001001655 AI078333 AI128560 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ALKBH2 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c ^ 4a · 4b · 4c
    SP1:                          -     -                                                   
    SP2:                          -     -                 -     -     -                     
    SP3:                                                                                    
    SP4:                    -     -     -                                                   
    SP5:                                                                                    


    ECgene alternative splicing isoforms for ALKBH2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ALKBH2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTTTAAACT
    ALKBH2 Expression
    About this image

    ALKBH2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ALKBH2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.374458

    UniProtKB/Swiss-Prot: ALKB2_HUMAN, Q6NS38
    Tissue specificity: Detected in colon, small intestine, ovary, testis, prostate, skeletal muscle, heart, liver and
    urinary bladder

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ALKBH2 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Alkbh21 , 5 alkB, alkylation repair homolog 2 (E. coli)1, 5 79.15(n)1
    84.26(a)1
      5 (55.97 cM)5
    2316421  NM_175016.21  NP_778181.21 
     1141239265 
    chicken
    (Gallus gallus)
    Aves ALKBH21 alkB, alkylation repair homolog 2 (E. coli) 67.09(n)
    68.2(a)
      416897  NM_001277497.1  NP_001264426.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.19742 Transcribed sequence with weak similarity to protein more 75.28(n)    BX760501.1 
    zebrafish
    (Danio rerio)
    Actinopterygii alkbh21 alkB, alkylation repair homolog 2 (E. coli) 59.14(n)
    58.06(a)
      569291  NM_001256684.1  NP_001243613.1 


    ENSEMBL Gene Tree for ALKBH2 (if available)
    TreeFam Gene Tree for ALKBH2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ALKBH2 gene
    ALKBH32  

    Find genes that share paralogs with ALKBH2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ALKBH2 (see all 169)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1815896951,2
    --109526395(+) TTTTCC/TTCACA 5 -- int10--------
    rs1858564431,2
    --109526421(+) CTGCAG/TGGCTG 5 -- int10--------
    rs1148046581,2
    F--109526551(+) GTCTCG/ACTCTG 5 -- int11Minor allele frequency- A:0.02WA 118
    rs1437072961,2
    --109526601(+) TGCAGC/TCTCGG 5 -- int10--------
    rs1467730881,2
    --109526605(+) GCCTCA/GGCCTC 5 -- int10--------
    rs1404584691,2
    --109526642(+) AGCCTC/GCCAAG 5 -- int10--------
    rs110690311,2
    C,F,A--109526754(+) AAGCAC/ATTCAC 5 -- int16Minor allele frequency- A:0.43NA WA EA 364
    rs110690421,2
    C,F,A,H--109526808(+) CCACGC/TCCGGC 5 -- int120Minor allele frequency- T:0.25NS EA WA NA 2346
    rs110690461,2
    C,F,H--109526858(+) AATCAC/TGTCTT 5 -- int18Minor allele frequency- T:0.03NS EA NA 928
    rs1454273251,2
    --109526859(+) ATCACA/GTCTTA 5 -- int10--------

    HapMap Linkage Disequilibrium report for ALKBH2 (109525993 - 109531436 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ALKBH2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2422361CNV Duplication17116639

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ALKBH2
    DNA2.0 Custom Variant and Variant Library Synthesis for ALKBH2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610602    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for ALKBH2:
    Mucoepidermoid carcinoma

    Find genes that share disorders with ALKBH2           About GenesLikeMe

    Genetic Association Database (GAD): ALKBH2
    Human Genome Epidemiology (HuGE) Navigator: ALKBH2 (2 documents)

    Export disorders for ALKBH2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ALKBH2 gene, integrated from 10 sources (see all 36):
    (articles sorted by number of sources associating them with ALKBH2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Crystal structures of DNA/RNA repair enzymes AlkB and ABH2 bound to dsDNA. (PubMed id 18432238)1, 2 Yang C.G....He C. (Nature 2008)
    2. AlkB homologue 2-mediated repair of ethenoadenine lesions in mammalian DNA. (PubMed id 18519673)1, 2 Ringvoll J....Klungland A. (Cancer Res. 2008)
    3. Repair of methylation damage in DNA and RNA by mammalian AlkB homologues. (PubMed id 16174769)1, 2 Lee D.-H.... O'Connor T.R. (J. Biol. Chem. 2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA. (PubMed id 12594517)1, 2 Aas P.A....Krokan H.E. (Nature 2003)
    6. Reversal of DNA alkylation damage by two human dioxygenases. (PubMed id 12486230)1, 2 Duncan T....Sedgwick B. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    7. ABH2 couples regulation of ribosomal DNA transcription with DNA alkylation repair. (PubMed id 23972994)1 Li P....Wong J. (Cell Rep 2013)
    8. ALKBH2, a novel AlkB homologue, contributes to human bladder cancer progression by regulating MUC1 expression. (PubMed id 23279696)1 Fujii T....Konishi N. (Cancer Sci. 2013)
    9. The DNA repair protein ALKBH2 mediates temozolomide resistance in human glioblastoma cells. (PubMed id 23258843)1 Johannessen T.C....Bjerkvig R. (Neuro-oncology 2013)
    10. Duplex interrogation by a direct DNA repair protein in search of base damage. (PubMed id 22659876)1 Yi C....He C. (amp 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 121642 HGNC: 32487 AceView: MGC90512 Ensembl:ENSG00000189046 euGenes: HUgn121642
    ECgene: ALKBH2 H-InvDB: ALKBH2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ALKBH2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ALKBH2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ALKBH2 gene:
    Search GeneIP for patents involving ALKBH2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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