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ALKBH1 Gene

protein-coding   GIFtS: 50
GCID: GC14M078138

AlkB, Alkylation Repair Homolog 1 (E. Coli)

(Previous names: alkB, alkylation repair homolog (E. coli))
(Previous symbol: ALKBH)
Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
AlkB, Alkylation Repair Homolog 1 (E. Coli)1 2     alkB2
ALKBH1 2 3     Alkylated DNA Repair Protein AlkB Homolog 12
Alpha-Ketoglutarate-Dependent Dioxygenase ABH12 3     Alkylation Repair, AlkB Homolog2
ABH2 3     hABH2
ABH12 3     EC 1.14.11.333
DNA Lyase ABH12 3     EC 4.2.99.183
DNA Oxidative Demethylase ALKBH12 3     ALKB5
AlkB, Alkylation Repair Homolog (E. Coli)1     

External Ids:    HGNC: 179111   Entrez Gene: 88462   Ensembl: ENSG000001006017   OMIM: 6053455   UniProtKB: Q136863   

Export aliases for ALKBH1 gene to outside databases

Previous GC identifers: GC14M077208 GC14M058306


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ALKBH1 Gene:
This gene encodes a homolog to the E. coli alkB gene product. The E. coli alkB protein is part of the adaptive
response mechanism of DNA alkylation damage repair. It is involved in damage reversal by oxidative demethylation
of 1-methyladenine and 3-methylcytosine. (provided by RefSeq, Jul 2008)

GeneCards Summary for ALKBH1 Gene:
ALKBH1 (alkB, alkylation repair homolog 1 (E. coli)) is a protein-coding gene. Diseases associated with ALKBH1 include lung cancer, and breast cancer. GO annotations related to this gene include DNA-(apurinic or apyrimidinic site) lyase activity and chemoattractant activity.

UniProtKB/Swiss-Prot: ALKB1_HUMAN, Q13686
Function: Dioxygenase that repairs alkylated single-stranded DNA and RNA containing 3-methylcytosine by oxidative
demethylation. Requires molecular oxygen, alpha-ketoglutarate and iron. May have a role in placental trophoblast
lineage differentiation (By similarity). Has DNA lyase activity and introduces double-stranded breaks at abasic
sites. Cleaves both single-stranded DNA and double-stranded DNA at abasic sites, with the greatest activity
towards double-stranded DNA with two abasic sites. DNA lyase activity does not require alpha-ketoglutarate and
iron




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000014.9  NT_026437.13  NC_018925.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ALKBH1 gene promoter:
         ER-alpha   Elk-1   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   Nkx2-5   POU3F2   FOXL1   C/EBPalpha   CHOP-10   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidALKBH1 promoter sequence
   Search Chromatin IP Primers for ALKBH1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ALKBH1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24.3   Ensembl cytogenetic band:  14q24.3   HGNC cytogenetic band: 14q24

ALKBH1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ALKBH1 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M078138:  view genomic region     (about GC identifiers)

Start:
78,138,747 bp from pter      End:
78,174,363 bp from pter
Size:
35,617 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ALKB1_HUMAN, Q13686 (See protein sequence)
Recommended Name: Alkylated DNA repair protein alkB homolog 1  
Size: 389 amino acids; 43832 Da
Cofactor: Binds 1 Fe(2+) ion per subunit
Subunit: Monomer. Interacts with DNAJB6 (By similarity)
Caution: Detected in cytoplasm and nucleus When expressed as fusion protein with an N-terminal tag, or when the
first 26 N-terminal residues are removed (PubMed:17979886 and PubMed:18603530). The endogenous, unmodified
protein localizes to mitochondria (PubMed:18603530)
Sequence caution: Sequence=CAA63047.1; Type=Frameshift; Positions=Several;
Secondary accessions: Q8TAU1 Q9ULA7

Explore the universe of human proteins at neXtProt for ALKBH1: NX_Q13686

Explore proteomics data for ALKBH1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ALKBH1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006011.2  
    ENSEMBL proteins: 
     ENSP00000216489   ENSP00000451886   ENSP00000451386  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ALKB: Alkylation repair homologs

    3 InterPro protein domains:
     IPR004574 Alkb
     IPR027450 AlkB-like
     IPR005123 Oxoglu/Fe-dep_dioxygenase

    Graphical View of Domain Structure for InterPro Entry Q13686

    ProtoNet protein and cluster: Q13686

    UniProtKB/Swiss-Prot: ALKB1_HUMAN, Q13686
    Similarity: Belongs to the alkB family
    Similarity: Contains 1 Fe2OG dioxygenase domain


    ALKBH1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ALKB1_HUMAN, Q13686
    Function: Dioxygenase that repairs alkylated single-stranded DNA and RNA containing 3-methylcytosine by oxidative
    demethylation. Requires molecular oxygen, alpha-ketoglutarate and iron. May have a role in placental trophoblast
    lineage differentiation (By similarity). Has DNA lyase activity and introduces double-stranded breaks at abasic
    sites. Cleaves both single-stranded DNA and double-stranded DNA at abasic sites, with the greatest activity
    towards double-stranded DNA with two abasic sites. DNA lyase activity does not require alpha-ketoglutarate and
    iron
    Catalytic activity: The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination
    reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
    Catalytic activity: DNA-base-CH(3) + 2-oxoglutarate + O(2) = DNA-base + formaldehyde + succinate + CO(2)

         Enzyme Numbers (IUBMB): EC 1.14.11.331 EC 4.2.99.181

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003906DNA-(apurinic or apyrimidinic site) lyase activity IDA19959401
    GO:0005515protein binding ----
    GO:0008198ferrous iron binding IDA18603530
    GO:0042056chemoattractant activity IEA--
    GO:0070579methylcytosine dioxygenase activity IDA18603530
         
    ALKBH1 for ontologies           About GeneDecksing


    Phenotypes:
         12 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Alkbh1):
     cardiovascular system  cellular  craniofacial  embryogenesis  endocrine/exocrine gland 
     growth/size/body  limbs/digits/tail  mortality/aging  nervous system  reproductive system 
     skeleton  vision/eye 

    ALKBH1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for ALKBH1: Alkbh1tm1.1Lpkn Alkbh1tm1Klng

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ALKBH1
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ALKBH1

    miRNA
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    miRTarBase miRNAs that target ALKBH1:
    hsa-mir-98-5p (MIRT027676)

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    Selected qRT-PCR Assays for microRNAs that regulate ALKBH1 (see all 25):
    hsa-miR-485-5p hsa-let-7d hsa-miR-202 hsa-let-7c hsa-miR-3921 hsa-miR-339-5p hsa-miR-570 hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmidALKBH1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ALKBH1

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ALKB1_HUMAN, Q13686: Mitochondrion. Nucleus (By similarity). Note=Mainly localizes in euchromatin, largely
    excluded from heterochromatin and nucleoli (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    extracellular2
    nucleus2
    cytosol1
    lysosome1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005719nuclear euchromatin IEA--
    GO:0005739mitochondrion IDA18603530

    ALKBH1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ALKBH1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Integrated Breast Cancer Pathway
    Integrated Breast Cancer Pathway


    1 BioSystems Pathway for ALKBH1
        Integrated Breast Cancer Pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ALKBH1
    Interactions:

        Search GeneGlobe Interaction Network for ALKBH1

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for ALKBH1 (Q136863 ENSP000002164894) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DNAJB6O751903, ENSP000002621774I2D: score=1 STRING: ENSP00000262177
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000737DNA catabolic process, endonucleolytic IDA19959401
    GO:0001701in utero embryonic development IEA--
    GO:0001764neuron migration IEA--
    GO:0001890placenta development IEA--
    GO:0006281DNA repair IDA18603530

    ALKBH1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ALKBH1 (ALKB1)

    10 Novoseek inferred chemical compound relationships for ALKBH1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    3-methylcytosine 97.9 6 15576352 (2), 12594517 (1), 17979886 (1), 19852088 (1)
    1-methyladenine 94.7 8 12944387 (2), 15576352 (2), 12594517 (1), 17979886 (1) (see all 5)
    alpha-ketoglutarate 73 5 19852088 (1), 16469386 (1), 17979886 (1), 12486230 (1)
    hexadecane 69.4 1 7804909 (1)
    methylnitrosourea 58.2 2 16358713 (1)
    naphthalene 54.9 4 7804909 (2), 18592409 (1), 11375152 (1)
    methylmethanesulfonate 47.4 6 10950872 (3), 8600462 (2)
    formaldehyde 37.4 2 19852088 (1), 12486230 (1)
    oxygen 15.6 1 19852088 (1)
    carbon 0 1 11418560 (1)



    ALKBH1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ALKBH1 gene (2 alternative transcripts): 
    NM_006020.2  NM_001039506.1  

    Unigene Cluster for ALKBH1:

    AlkB, alkylation repair homolog 1 (E. coli)
    Hs.94542  [show with all ESTs]
    Unigene Representative Sequence: NM_006020
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000216489(uc001xuc.1) ENST00000557057 ENST00000555100 ENST00000554097

    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Selected qRT-PCR Assays for microRNAs that regulate ALKBH1 (see all 25):
    hsa-miR-485-5p hsa-let-7d hsa-miR-202 hsa-let-7c hsa-miR-3921 hsa-miR-339-5p hsa-miR-570 hsa-let-7g
    SwitchGear 3'UTR luciferase reporter plasmidALKBH1 3' UTR sequence
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    Additional mRNA sequence: 

    BC015024.1 BC025787.1 X91992.1 

    6 DOTS entries:

    DT.95269865  DT.108343  DT.110436  DT.100843274  DT.92420358  DT.95269867 

    Selected AceView cDNA sequences (see all 72):

    N79558 BE552451 BM726354 AI368879 N77150 BF062252 BF194721 AI668640 
    CR604550 AA811353 BM726581 BI822148 BF057641 BI223337 BU623623 AI572185 
    BX375565 BU165019 BC015024 AA609609 BF963468 AA759044 AW794512 BE873425 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ALKBH1    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d
    SP1:                                                                        
    SP2:                          -                                             
    SP3:                          -           -                                 
    SP4:                    -     -                                             


    ECgene alternative splicing isoforms for ALKBH1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ALKBH1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATAAACTCA
    ALKBH1 Expression
    About this image

    ALKBH1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ALKBH1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.94542

    UniProtKB/Swiss-Prot: ALKB1_HUMAN, Q13686
    Tissue specificity: Ubiquitous

        Custom PCR Arrays for ALKBH1
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALKBH1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ALKBH1 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Alkbh11 , 5 alkB, alkylation repair homolog 1 (E. coli)1, 5 84.49(n)1
    82.78(a)1
      12 (41.65 cM)5
    2110641  NM_001102565.11  NP_001096035.11 
     874258405 
    chicken
    (Gallus gallus)
    Aves ALKBH11 alkB, alkylation repair homolog 1 (E. coli) 69.03(n)
    70.49(a)
      428898  NM_001031552.2  NP_001026723.1 
    lizard
    (Anolis carolinensis)
    Reptilia ALKBH16
    alkB, alkylation repair homolog 1 (E. coli)
    65(a)
    1 ↔ 1
    1(20512145-20528545)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.249692 Xenopus laevis transcribed sequence with weak similarity to protein spQ13686 (H.sapiens) ALKB_HUMAN Alkylated DNA repair protein alkB homolog less 73.33(n)    CA987539.1 
    zebrafish
    (Danio rerio)
    Actinopterygii alkbh11 alkB, alkylation repair homolog 1 (E. coli) 60.7(n)
    59.7(a)
      553720  NM_001020691.1  NP_001018527.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta AlkB1 AlkB 46.26(n)
    38.46(a)
      2768870  NM_206735.1  NP_996458.1 
    worm
    (Caenorhabditis elegans)
    Secernentea Y51H7C.51 Y51H7C.5 45.1(n)
    34.95(a)
      190176  NM_061568.6  NP_493969.4 


    ENSEMBL Gene Tree for ALKBH1 (if available)
    TreeFam Gene Tree for ALKBH1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ALKBH1 (see all 784)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1857351301,2
    --78138250(+) AGAATA/TATCTG 1 -- ds50010--------
    rs1997828121,2
    C--78138253(+) ATAAT-/CTGTCT 1 -- ds50010--------
    rs789043351,2
    C,F--78138254(+) TAATCT/CGTCTT 1 -- ds50013Minor allele frequency- C:0.11CSA WA NA 240
    rs116241181,2
    C,F,H--78138300(+) CAGTAC/TGTTGG 1 -- ds500119Minor allele frequency- T:0.43NS EA NA CSA WA 2343
    rs1138091401,2
    C--78138493(+) TGAGAA/TCAGGA 1 -- ds50010--------
    rs1901057851,2
    --78138507(+) CAAGAC/TCAGCC 1 -- ds50010--------
    rs1829342301,2
    --78138583(+) CCTGTA/GATGCC 1 -- ds50010--------
    rs1860665101,2
    --78138588(+) AATGCC/TAGCTA 1 -- ds50010--------
    rs1909708761,2
    --78138626(+) TTGAAC/TCCGGG 1 -- ds50010--------
    rs1465939071,2
    --78138629(+) AACCCA/GGGAGG 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for ALKBH1 (78138747 - 78174363 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for ALKBH1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv9156CNV Loss18304495
    nsv521287CNV Gain19592680
    esv34940CNV Gain17911159
    nsv520021CNV Gain19592680
    essv7944CNV CNV17122850
    dgv643e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605345    OMIM disorders: --

    4 diseases for ALKBH1:    About MalaCards
    lung cancer    breast cancer    neuronitis    malaria


    ALKBH1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    1 Novoseek inferred disease relationship for ALKBH1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 0 1 19293182 (1)


    Export disorders for ALKBH1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ALKBH1 gene, integrated from 10 sources (see all 58):
    (articles sorted by number of sources associating them with ALKBH1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and functional analysis of a human cDNA encoding an Escherichia coli AlkB homolog, a protein involved in DNA alkylation damage repair. (PubMed id 8600462)1, 2, 3, 9 Wei Y.F.... Shell B.K. (Nucleic Acids Res. 1996)
    2. Human AlkB homologue 1 (ABH1) exhibits DNA lyase activity at abasic sites. (PubMed id 19959401)1, 2, 9 Muller T.A.... Hausinger R.P. (DNA Repair 2010)
    3. Human AlkB homolog 1 is a mitochondrial protein that demethylates 3- methylcytosine in DNA and RNA. (PubMed id 18603530)1, 2 Westbye M.P.... Krokan H.E. (J. Biol. Chem. 2008)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)1, 2 Heilig R.... Weissenbach J. (Nature 2003)
    6. Expression and sub-cellular localization of human ABH family molecules. (PubMed id 17979886)2, 9 Tsujikawa K.... Yamamoto H. (J. Cell. Mol. Med. 2007)
    7. Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA. (PubMed id 12594517)1, 9 Aas P.A....Krokan H.E. (Nature 2003)
    8. ALKBH1 is dispensable for abasic site cleavage during base excision repair and class switch recombination. (PubMed id 23825659)1 MA1ller T.A....Meek K. (PLoS ONE 2013)
    9. A covalent protein-DNA 5'-product adduct is generated following AP lyase activity of human ALKBH1 (AlkB homologue 1). (PubMed id 23577621)1 MA1ller T.A....Hausinger R.P. (Biochem. J. 2013)
    10. Genome-wide association study of prognosis in advanced non-small cell lung cancer patients receiving platinum-based chemotherapy. (PubMed id 22872573)1 Hu L....Shen H. (Clin. Cancer Res. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8846 HGNC: 17911 AceView: ALKBH Ensembl:ENSG00000100601 euGenes: HUgn8846
    ECgene: ALKBH1 H-InvDB: ALKBH1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ALKBH1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ALKBH1 gene:
    Search GeneIP for patents involving ALKBH1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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