Aliases for ALKBH1 Gene
External Ids for ALKBH1 Gene
Previous HGNC Symbols for ALKBH1 Gene
Previous GeneCards Identifiers for ALKBH1 Gene
This gene encodes a homolog to the E. coli alkB gene product. The E. coli alkB protein is part of the adaptive response mechanism of DNA alkylation damage repair. It is involved in damage reversal by oxidative demethylation of 1-methyladenine and 3-methylcytosine. [provided by RefSeq, Jul 2008]
GeneCards Summary for ALKBH1 Gene
ALKBH1 (AlkB Homolog 1, Histone H2A Dioxygenase) is a Protein Coding gene. Diseases associated with ALKBH1 include salivary gland cancer. Among its related pathways are Integrated Breast Cancer Pathway. GO annotations related to this gene include chemoattractant activity and DNA-(apurinic or apyrimidinic site) lyase activity.
UniProtKB/Swiss-Prot for ALKBH1 Gene
Dioxygenase that repairs alkylated single-stranded DNA and RNA containing 3-methylcytosine by oxidative demethylation. Requires molecular oxygen, alpha-ketoglutarate and iron. May have a role in placental trophoblast lineage differentiation (By similarity). Has DNA lyase activity and introduces double-stranded breaks at abasic sites. Cleaves both single-stranded DNA and double-stranded DNA at abasic sites, with the greatest activity towards double-stranded DNA with two abasic sites. DNA lyase activity does not require alpha-ketoglutarate and iron.