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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ALKBH1 Gene

protein-coding   GIFtS: 50
GCID: GC14M078138

AlkB, Alkylation Repair Homolog 1 (E. Coli)

(Previous names: alkB, alkylation repair homolog (E. coli))
(Previous symbol: ALKBH)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
AlkB, Alkylation Repair Homolog 1 (E. Coli)1 2     alkB2
ALKBH1 2 3     Alkylated DNA Repair Protein AlkB Homolog 12
Alpha-Ketoglutarate-Dependent Dioxygenase ABH12 3     Alkylation Repair, AlkB Homolog2
ABH2 3     hABH2
ABH12 3     EC 1.14.11.333
DNA Lyase ABH12 3     EC 4.2.99.183
DNA Oxidative Demethylase ALKBH12 3     ALKB5
AlkB, Alkylation Repair Homolog (E. Coli)1     

External Ids:    HGNC: 179111   Entrez Gene: 88462   Ensembl: ENSG000001006017   OMIM: 6053455   UniProtKB: Q136863   

Export aliases for ALKBH1 gene to outside databases

Previous GC identifers: GC14M077208 GC14M058306


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ALKBH1 Gene:
This gene encodes a homolog to the E. coli alkB gene product. The E. coli alkB protein is part of the adaptive
response mechanism of DNA alkylation damage repair. It is involved in damage reversal by oxidative demethylation
of 1-methyladenine and 3-methylcytosine. (provided by RefSeq, Jul 2008)

GeneCards Summary for ALKBH1 Gene: 
ALKBH1 (alkB, alkylation repair homolog 1 (E. coli)) is a protein-coding gene. Diseases associated with ALKBH1 include neuronitis, and lung cancer. GO annotations related to this gene include oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen and ferrous iron binding.

UniProtKB/Swiss-Prot: ALKB1_HUMAN, Q13686
Function: Dioxygenase that repairs alkylated single-stranded DNA and RNA containing 3-methylcytosine by oxidative
demethylation. Requires molecular oxygen, alpha-ketoglutarate and iron. May have a role in placental trophoblast
lineage differentiation (By similarity). Has DNA lyase activity and introduces double-stranded breaks at abasic
sites. Cleaves both single-stranded DNA and double-stranded DNA at abasic sites, with the greatest activity
towards double-stranded DNA with two abasic sites. DNA lyase activity does not require alpha-ketoglutarate and
iron




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NT_026437.12  NC_018925.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ALKBH1 gene promoter:
         ER-alpha   Elk-1   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   Nkx2-5   POU3F2   FOXL1   C/EBPalpha   CHOP-10   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidALKBH1 promoter sequence
   Search SABiosciences Chromatin IP Primers for ALKBH1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ALKBH1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24.3   Ensembl cytogenetic band:  14q24.3   HGNC cytogenetic band: 14q24

ALKBH1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ALKBH1 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M078138:  view genomic region     (about GC identifiers)

Start:
78,138,747 bp from pter      End:
78,174,363 bp from pter
Size:
35,617 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ALKB1_HUMAN, Q13686 (See protein sequence)
Recommended Name: Alkylated DNA repair protein alkB homolog 1  
Size: 389 amino acids; 43832 Da
Cofactor: Binds 1 Fe(2+) ion per subunit
Subunit: Monomer. Interacts with DNAJB6 (By similarity)
Subcellular location: Mitochondrion. Nucleus (By similarity). Note=Mainly localizes in euchromatin, largely
excluded from heterochromatin and nucleoli (By similarity)
Caution: Detected in cytoplasm and nucleus When expressed as fusion protein with an N-terminal tag, or when the
first 26 N-terminal residues are removed (PubMed:17979886 and PubMed:18603530). The endogenous, unmodified
protein localizes to mitochondria (PubMed:18603530)
Sequence caution: Sequence=CAA63047.1; Type=Frameshift; Positions=Several;
Secondary accessions: Q8TAU1 Q9ULA7

Explore the universe of human proteins at neXtProt for ALKBH1: NX_Q13686

Explore proteomics data for ALKBH1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q13686

  • ALKBH1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ALKBH1 Protein Expression
    REFSEQ proteins: NP_006011.2  
    ENSEMBL proteins: 
     ENSP00000216489   ENSP00000451886   ENSP00000451386  

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    Browse Sino Biological Recombinant Proteins
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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ALKBH1 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005719nuclear euchromatin IEA--
    GO:0005739mitochondrion IDA18603530

    ALKBH1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ALKB: Alkylation repair homologs

    3 InterPro protein domains:
     IPR027450 AlkB-like
     IPR004574 Alkb
     IPR005123 Oxoglu/Fe-dep_dioxygenase

    Graphical View of Domain Structure for InterPro Entry Q13686

    ProtoNet protein and cluster: Q13686

    UniProtKB/Swiss-Prot: ALKB1_HUMAN, Q13686
    Similarity: Belongs to the alkB family
    Similarity: Contains 1 Fe2OG dioxygenase domain


    ALKBH1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ALKB1_HUMAN, Q13686
    Function: Dioxygenase that repairs alkylated single-stranded DNA and RNA containing 3-methylcytosine by oxidative
    demethylation. Requires molecular oxygen, alpha-ketoglutarate and iron. May have a role in placental trophoblast
    lineage differentiation (By similarity). Has DNA lyase activity and introduces double-stranded breaks at abasic
    sites. Cleaves both single-stranded DNA and double-stranded DNA at abasic sites, with the greatest activity
    towards double-stranded DNA with two abasic sites. DNA lyase activity does not require alpha-ketoglutarate and
    iron
    Catalytic activity: The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination
    reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
    Catalytic activity: DNA-base-CH(3) + 2-oxoglutarate + O(2) = DNA-base + formaldehyde + succinate + CO(2)

         Enzyme Numbers (IUBMB): EC 1.14.11.331 EC 4.2.99.181

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003906DNA-(apurinic or apyrimidinic site) lyase activity IDA19959401
    GO:0005515protein binding ----
    GO:0008198ferrous iron binding IDA18603530
    GO:0016702oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ----
    GO:0042056chemoattractant activity IEA--
         
    ALKBH1 for ontologies           About GeneDecksing


    Phenotypes:
         12 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Alkbh1):
     cardiovascular system  cellular  craniofacial  embryogenesis  endocrine/exocrine gland 
     growth/size  limbs/digits/tail  mortality/aging  nervous system  reproductive system 
     skeleton  vision/eye 

    ALKBH1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for ALKBH1: Alkbh1tm1.1Lpkn Alkbh1tm1Klng

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ALKBH1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ALKBH1

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    SwitchGear 3'UTR luciferase reporter plasmidALKBH1 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALKBH1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ALKBH1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Integrated Breast Cancer Pathway
    Integrated Breast Cancer Pathway


    1 BioSystems Pathway for ALKBH1
        Integrated Breast Cancer Pathway


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ALKBH1

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for ALKBH1 (Q136863 ENSP000002164894) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DNAJB6O751903, ENSP000002621774I2D: score=1 STRING: ENSP00000262177
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001701in utero embryonic development IEA--
    GO:0001764neuron migration IEA--
    GO:0001890placenta development IEA--
    GO:0006281DNA repair IDA18603530
    GO:0006307DNA dealkylation involved in DNA repair IDA18603530

    ALKBH1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ALKBH1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ALKBH1 (ALKB1)

    10 Novoseek inferred chemical compound relationships for ALKBH1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    3-methylcytosine 97.9 6 15576352 (2), 12594517 (1), 17979886 (1), 19852088 (1)
    1-methyladenine 94.7 8 12944387 (2), 15576352 (2), 12594517 (1), 17979886 (1) (see all 5)
    alpha-ketoglutarate 73 5 19852088 (1), 16469386 (1), 17979886 (1), 12486230 (1)
    hexadecane 69.4 1 7804909 (1)
    methylnitrosourea 58.2 2 16358713 (1)
    naphthalene 54.9 4 7804909 (2), 18592409 (1), 11375152 (1)
    methylmethanesulfonate 47.4 6 10950872 (3), 8600462 (2)
    formaldehyde 37.4 2 19852088 (1), 12486230 (1)
    oxygen 15.6 1 19852088 (1)
    carbon 0 1 11418560 (1)

    Search CenterWatch for drugs/clinical trials and news about ALKBH1 / ALKB1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ALKBH1 gene (2 alternative transcripts): 
    NM_006020.2  NM_001039506.1  

    Unigene Cluster for ALKBH1:

    AlkB, alkylation repair homolog 1 (E. coli)
    Hs.94542  [show with all ESTs]
    Unigene Representative Sequence: NM_006020
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000216489(uc001xuc.1) ENST00000557057 ENST00000555100 ENST00000554097

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    hsa-miR-485-5p hsa-let-7d hsa-miR-202 hsa-let-7c hsa-miR-3921 hsa-miR-339-5p hsa-miR-570 hsa-let-7g
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    Additional mRNA sequence: 

    BC015024.1 BC025787.1 X91992.1 

    6 DOTS entries:

    DT.95269865  DT.108343  DT.110436  DT.100843274  DT.92420358  DT.95269867 

    24/72 AceView cDNA sequences (see all 72):

    BF057641 AI368879 N77150 BE552451 BF062252 BI822148 AA811353 BM726354 
    AI668640 CR604550 N79558 BM726581 BF194721 BX537699 AA298689 BE873425 
    X91992 AW794512 BM681225 BX105183 AI734243 BF062195 BX375565 NM_006020 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ALKBH1    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d
    SP1:                                                                        
    SP2:                          -                                             
    SP3:                          -           -                                 
    SP4:                    -     -                                             


    ECgene alternative splicing isoforms for ALKBH1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ALKBH1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATAAACTCA
    ALKBH1 Expression
    About this image


    See ALKBH1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ALKBH1

    SOURCE GeneReport for Unigene cluster: Hs.94542

    UniProtKB/Swiss-Prot: ALKB1_HUMAN, Q13686
    Tissue specificity: Ubiquitous

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALKBH1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ALKBH1 gene from 7/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Alkbh11 , 5 alkB, alkylation repair homolog 1 (E. coli)1, 5 84.49(n)1
    82.78(a)1
      12 (41.65 cM)5
    2110641  NM_001102565.11  NP_001096035.11 
     874258405 
    chicken
    (Gallus gallus)
    Aves ALKBH11 alkB, alkylation repair homolog 1 (E. coli) 69.32(n)
    70.88(a)
      428898  NM_001031552.1  NP_001026723.1 
    lizard
    (Anolis carolinensis)
    Reptilia ALKBH16
    Uncharacterized protein
    65(a)
    1 ↔ 1
    1(20512145-20528545)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.249692 Xenopus laevis transcribed sequence with weak similarity more 73.33(n)    CA987539.1 
    zebrafish
    (Danio rerio)
    Actinopterygii alkbh11 alkB, alkylation repair homolog 1 (E. coli) 60.7(n)
    59.7(a)
      553720  NM_001020691.1  NP_001018527.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta AlkB1 AlkB 46.26(n)
    38.46(a)
      2768870  NM_206735.1  NP_996458.1 
    worm
    (Caenorhabditis elegans)
    Secernentea Y51H7C.51 Protein Y51H7C.5 42.58(n)
    31.41(a)
      190176  NM_061568.5  NP_493969.3 


    ENSEMBL Gene Tree for ALKBH1 (if available)
    TreeFam Gene Tree for ALKBH1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/784 SNPs in ALKBH1 are shown (see all 784)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1857351301,2
    --78138250(+) AGAATA/TATCTG 1 -- ds50010--------
    rs1997828121,2
    C--78138253(+) ATAAT-/CTGTCT 1 -- ds50010--------
    rs789043351,2
    C,F--78138254(+) TAATCT/CGTCTT 1 -- ds50013Minor allele frequency- C:0.11CSA WA NA 240
    rs116241181,2
    C,F,H--78138300(+) CAGTAC/TGTTGG 1 -- ds500119Minor allele frequency- T:0.43NS EA NA CSA WA 2343
    rs1138091401,2
    C--78138493(+) TGAGAA/TCAGGA 1 -- ds50010--------
    rs1901057851,2
    --78138507(+) CAAGAC/TCAGCC 1 -- ds50010--------
    rs1829342301,2
    --78138583(+) CCTGTA/GATGCC 1 -- ds50010--------
    rs1860665101,2
    --78138588(+) AATGCC/TAGCTA 1 -- ds50010--------
    rs1909708761,2
    --78138626(+) TTGAAC/TCCGGG 1 -- ds50010--------
    rs1465939071,2
    --78138629(+) AACCCA/GGGAGG 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for ALKBH1 (78138747 - 78174363 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for ALKBH1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv9156CNV Loss18304495
    nsv521287CNV Gain19592680
    esv34940CNV Gain17911159
    nsv520021CNV Gain19592680
    essv7944CNV CNV17122850
    dgv643e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605345    OMIM disorders: --

    3 diseases for ALKBH1:    About MalaCards
    neuronitis    lung cancer    breast cancer


    ALKBH1 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for ALKBH1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 0 1 19293182 (1)


    Export disorders for ALKBH1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ALKBH1 gene, integrated from 9 sources (see all 56):
    (articles sorted by number of sources associating them with ALKBH1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and functional analysis of a human cDNA encoding an Escherichia coli AlkB homolog, a protein involved in DNA alkylation damage repair. (PubMed id 8600462)1, 2, 3, 9 Wei Y.F.... Shell B.K. (1996)
    2. Human AlkB homologue 1 (ABH1) exhibits DNA lyase acti vity at abasic sites. (PubMed id 19959401)1, 2, 9 MA1ller T.A....Hausinger R.P. (2010)
    3. Human AlkB homolog 1 is a mitochondrial protein that demethylates 3-methylcytosine in DNA and RNA. (PubMed id 18603530)1, 2 Westbye M.P....Krokan H.E. (2008)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)1, 2 Heilig R.... Weissenbach J. (2003)
    6. Expression and sub-cellular localization of human ABH family molecules. (PubMed id 17979886)2, 9 Tsujikawa K....Yamamoto H. (2007)
    7. Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA. (PubMed id 12594517)1, 9 Aas P.A....Krokan H.E. (2003)
    8. A covalent protein-DNA 5'-product adduct is generated following AP lyase activity of human ALKBH1 (AlkB homologue 1). (PubMed id 23577621)1 Muller T.A....Hausinger R.P. (2013)
    9. Genome-wide association study of prognosis in advanced non-small cell lung cancer patients receiving platinum-based chemotherapy. (PubMed id 22872573)1 Hu L....Shen H. (2012)
    10. Homology modeling and function prediction of hABH1, in volving in repair of alkylation damaged DNA. (PubMed id 21956739)1 Shankaracharya ....Vidyarthi A.S. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8846 HGNC: 17911 AceView: ALKBH Ensembl:ENSG00000100601 euGenes: HUgn8846
    ECgene: ALKBH1 H-InvDB: ALKBH1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ALKBH1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ALKBH1 gene:
    Search GeneIP for patents involving ALKBH1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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