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Aliases for ALKAL2 Gene

Aliases for ALKAL2 Gene

  • ALK And LTK Ligand 2 2 3 5
  • Family With Sequence Similarity 150 Member B 2 3
  • Augmentor Alpha 3 4
  • AUG-Alpha 3 4
  • FAM150B 3 4
  • Family With Sequence Similarity 150, Member B 2
  • Augmentor-Alpha 2
  • Protein FAM150B 3
  • Augmentor-Beta 3
  • PRO1097 3
  • RGPG542 3
  • AUGA 3

External Ids for ALKAL2 Gene

Previous HGNC Symbols for ALKAL2 Gene

  • FAM150B

Summaries for ALKAL2 Gene

GeneCards Summary for ALKAL2 Gene

ALKAL2 (ALK And LTK Ligand 2) is a Protein Coding gene. An important paralog of this gene is ALKAL1.

UniProtKB/Swiss-Prot for ALKAL2 Gene

  • Ligand for receptor tyrosine kinases LTK and ALK. Stimulation of ALK signaling may be involved in regulation of cell proliferation and transformation.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ALKAL2 Gene

Genomics for ALKAL2 Gene

Regulatory Elements for ALKAL2 Gene

Enhancers for ALKAL2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G000260 1.4 ENCODE dbSUPER 30.9 +25.5 25487 6.6 PKNOX1 FOXA2 CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SH3YL1 ALKAL2 LOC101927262 ENSG00000227061 ACP1 GC02M000255
GH02G000289 1.2 FANTOM5 ENCODE 17.3 -0.9 -913 1.3 ELF3 CBX3 ARID4B DNMT3B ZNF48 RAD21 YY1 EGR1 ZNF143 MXD4 SH3YL1 ALKAL2 ENSG00000277997
GH02G000033 1.1 ENCODE dbSUPER 10 +252.6 252624 6.5 TBP ELF3 PKNOX1 NFIB SIN3A BMI1 RAD21 SLC30A9 HSF1 SCRT2 ALKAL2 LOC101927262 FAM110C LOC105373346 SH3YL1 LOC102724983 LOC105379575
GH02G000317 0.9 Ensembl ENCODE 11 -28.9 -28882 0.9 FOSL1 JUND POLR2A SMARCA4 NR2F1 FOS NR2F2 NR2C2 ALKAL2 LOC101927262 LINC01865 LOC105373351
GH02G000280 0.5 ENCODE 19.4 +8.0 8048 1.7 CTCF RAD21 NR2F2 SH3YL1 ALKAL2 ENSG00000227061 LOC101927262
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ALKAL2 on UCSC Golden Path with GeneCards custom track

Promoters for ALKAL2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000289385 979 1000 HDAC2 RNF2 CHD1 FOXP2 ZBTB26 EZH2

Genomic Location for ALKAL2 Gene

Chromosome:
2
Start:
279,558 bp from pter
End:
288,880 bp from pter
Size:
9,323 bases
Orientation:
Minus strand

Genomic View for ALKAL2 Gene

Genes around ALKAL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ALKAL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ALKAL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ALKAL2 Gene

Proteins for ALKAL2 Gene

  • Protein details for ALKAL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UX46-F150B_HUMAN
    Recommended name:
    Protein FAM150B
    Protein Accession:
    Q6UX46
    Secondary Accessions:
    • B5MC76

    Protein attributes for ALKAL2 Gene

    Size:
    152 amino acids
    Molecular mass:
    16915 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ALKAL2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ALKAL2 Gene

Post-translational modifications for ALKAL2 Gene

No Post-translational modifications

No data available for DME Specific Peptides for ALKAL2 Gene

Domains & Families for ALKAL2 Gene

Protein Domains for ALKAL2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ALKAL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6UX46

UniProtKB/Swiss-Prot:

F150B_HUMAN :
  • Belongs to the FAM150 family.
Family:
  • Belongs to the FAM150 family.
genes like me logo Genes that share domains with ALKAL2: view

No data available for Gene Families for ALKAL2 Gene

Function for ALKAL2 Gene

Molecular function for ALKAL2 Gene

UniProtKB/Swiss-Prot Function:
Ligand for receptor tyrosine kinases LTK and ALK. Stimulation of ALK signaling may be involved in regulation of cell proliferation and transformation.

Gene Ontology (GO) - Molecular Function for ALKAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 26418745
GO:0030298 receptor signaling protein tyrosine kinase activator activity IDA 26418745
GO:0030971 receptor tyrosine kinase binding IDA 26418745
genes like me logo Genes that share ontologies with ALKAL2: view

Phenotypes for ALKAL2 Gene

genes like me logo Genes that share phenotypes with ALKAL2: view

Animal Model Products

miRNA for ALKAL2 Gene

miRTarBase miRNAs that target ALKAL2

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ALKAL2 Gene

Localization for ALKAL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ALKAL2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ALKAL2 gene
Compartment Confidence
extracellular 5

Gene Ontology (GO) - Cellular Components for ALKAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with ALKAL2: view

Pathways & Interactions for ALKAL2 Gene

SuperPathways for ALKAL2 Gene

No Data Available

Interacting Proteins for ALKAL2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000384604%0d%0a9606.ENSP00000373700%0d%0a
Selected Interacting proteins: Q6UX46-F150B_HUMAN ENSP00000384604 for ALKAL2 Gene via UniProtKB STRING

Gene Ontology (GO) - Biological Process for ALKAL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010976 positive regulation of neuron projection development IDA 26418745
GO:0061098 positive regulation of protein tyrosine kinase activity IEA --
GO:0070374 positive regulation of ERK1 and ERK2 cascade IDA 26418745
GO:0070378 positive regulation of ERK5 cascade IDA 26418745
genes like me logo Genes that share ontologies with ALKAL2: view

No data available for Pathways by source and SIGNOR curated interactions for ALKAL2 Gene

Drugs & Compounds for ALKAL2 Gene

No Compound Related Data Available

Transcripts for ALKAL2 Gene

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ALKAL2 Gene

No ASD Table

Relevant External Links for ALKAL2 Gene

GeneLoc Exon Structure for
ALKAL2
ECgene alternative splicing isoforms for
ALKAL2

Expression for ALKAL2 Gene

NURSA nuclear receptor signaling pathways regulating expression of ALKAL2 Gene:

ALKAL2

mRNA Expression by UniProt/SwissProt for ALKAL2 Gene:

Q6UX46-F150B_HUMAN
Tissue specificity: Widely expressed with highest levels in adrenal gland and modest levels in pancreas, testis and uterus.

Evidence on tissue expression from TISSUES for ALKAL2 Gene

  • Adrenal gland(2)

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for ALKAL2 Gene

Orthologs for ALKAL2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ALKAL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FAM150B 34 35
  • 99.34 (n)
cow
(Bos Taurus)
Mammalia FAM150B 34
  • 82.11 (n)
rat
(Rattus norvegicus)
Mammalia Fam150b 34
  • 79.13 (n)
mouse
(Mus musculus)
Mammalia Fam150b 34 16 35
  • 78.59 (n)
oppossum
(Monodelphis domestica)
Mammalia FAM150B 35
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FAM150B 35
  • 50 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM150B 34 35
  • 69.52 (n)
lizard
(Anolis carolinensis)
Reptilia FAM150B 35
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam150b 34
  • 63.96 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100329254 34
  • 57.65 (n)
fam150ba 35
  • 43 (a)
OneToMany
fam150bb 35
  • 35 (a)
OneToMany
Species where no ortholog for ALKAL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ALKAL2 Gene

ENSEMBL:
Gene Tree for ALKAL2 (if available)
TreeFam:
Gene Tree for ALKAL2 (if available)

Paralogs for ALKAL2 Gene

Paralogs for ALKAL2 Gene

genes like me logo Genes that share paralogs with ALKAL2: view

Variants for ALKAL2 Gene

Sequence variations from dbSNP and Humsavar for ALKAL2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000235432 -- 286,251(+) GAAAA(A/G)GAGCT intron-variant, nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime
rs1000298119 -- 280,852(+) GGGCA(A/G)AGCCC intron-variant
rs1000327473 -- 281,183(+) CAATT(A/T)GCTGT intron-variant
rs1000438974 -- 285,083(+) GCGTT(-/C)CATGC intron-variant, upstream-variant-2KB
rs1000491307 -- 284,638(+) GAGGT(A/G)TCGAA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ALKAL2 Gene

Variant ID Type Subtype PubMed ID
dgv3698n100 CNV gain 25217958
esv2759016 CNV gain 17122850
esv3589598 CNV gain 21293372
esv3589599 CNV gain 21293372
nsv1072370 CNV deletion 25765185
nsv833159 CNV loss 17160897
nsv833170 CNV loss 17160897

Variation tolerance for ALKAL2 Gene

Gene Damage Index Score: 0.08; 1.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ALKAL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ALKAL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ALKAL2 Gene

Disorders for ALKAL2 Gene

Relevant External Links for ALKAL2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ALKAL2

No disorders were found for ALKAL2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ALKAL2 Gene

Publications for ALKAL2 Gene

  1. FAM150A and FAM150B are activating ligands for anaplastic lymphoma kinase. (PMID: 26418745) Guan J. … Palmer R.H. (Elife 2015) 2 3 4 64
  2. Augmentor alpha and beta (FAM150) are ligands of the receptor tyrosine kinases ALK and LTK: Hierarchy and specificity of ligand- receptor interactions. (PMID: 26630010) Reshetnyak A.V. … Schlessinger J. (Proc. Natl. Acad. Sci. U.S.A. 2015) 2 3 4 64
  3. Deorphanization of the human leukocyte tyrosine kinase (LTK) receptor by a signaling screen of the extracellular proteome. (PMID: 25331893) Zhang H. … Williams L.T. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3 4 64
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 4 64

Products for ALKAL2 Gene

Sources for ALKAL2 Gene

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