ALK Gene
protein-coding GIFtS: 65
GCID: GC02M029327
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|
anaplastic lymphoma receptor tyrosine kinase(Previous name: anaplastic lymphoma kinase (Ki-1) )
| |
Aliases
for ALK gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Anaplastic Lymphoma Receptor Tyrosine Kinase1 2 | | Anaplastic Lymphoma Kinase (Ki-1)1 | | CD2461 2 | | ALK Tyrosine Kinase Receptor2 | | CD246 Antigen2 3 | | Mutant Anaplastic Lymphoma Kinase2 | | EC 2.7.10.13 8 | | Anaplastic Lymphoma Kinase3 | | NBLST32 5 | | |
Export aliases for ALK gene to outside databasesPrevious GC identifers: GC02M029337 GC02M029508 GC02M029390 GC02M029269 GC02M029156 |
Summaries
for ALK gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ALK:
This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprisesan extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and anintracellular kinase domain. It plays an important role in the development of the brain and exerts its effects onspecific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a seriesof tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomalrearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genesin tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC(chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).(provided by RefSeq, Jan 2011)
UniProtKB/Swiss-Prot: ALK_HUMAN, Q9UM73Function: Neuronal orphan receptor tyrosine kinase that is essentially and transiently expressed in specific regions ofthe central and peripheral nervous systems and plays an important role in the genesis and differentiation of thenervous system. Transduces signals from ligands at the cell surface, through specific activation of themitogen-activated protein kinase (MAPK) pathway. Phosphorylates almost exclusively at the first tyrosine of theY-x-x-x-Y-Y motif. Following activation by ligand, ALK induces tyrosine phosphorylation of CBL, FRS2, IRS1 and SHC1,as well as of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Acts as a receptor for ligands pleiotrophin (PTN), a secretedgrowth factor, and midkine (MDK), a PTN-related factor, thus participating in PTN and MDK signal transduction.PTN-binding induces MAPK pathway activation, which is important for the anti-apoptotic signaling of PTN and regulationof cell proliferation. MDK-binding induces phosphorylation of the ALK target insulin receptor substrate (IRS1),activates mitogen-activated protein kinases (MAPKs) and PI3-kinase, resulting also in cell proliferation induction.Drives NF-kappa-B activation, probably through IRS1 and the activation of the AKT serine/threonine kinase. Recruitmentof IRS1 to activated ALK and the activation of NF-kappa-B are essential for the autocrine growth and survivalsignaling of MDK
Gene Wiki entry for ALK (Anaplastic lymphoma kinase)
|
Genomic Views
for ALK gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022184.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ALK gene promoter:
p53 AP-1 ATF-2 Nkx2-5 CUTL1 AREB6 STAT3 c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for ALK
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ALK |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2p23 Ensembl cytogenetic band: 2p23.1 HGNC cytogenetic band: 2p23ALK Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M029327: view genomic region
(about GC identifiers)
Start:
|
29,415,640 bp from pter |
End:
|
30,144,432 bp from pter |
Size:
|
728,793 bases |
Orientation:
|
minus strand |
|
Proteins
for ALK gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ALK_HUMAN, Q9UM73 (See
protein sequence)Recommended Name: ALK tyrosine kinase receptor precursor Size: 1620 amino acids; 176442 Da
Subunit: Homodimer. Homodimerizes when bound to ligand. Interacts with FRS2, IRS1, MDK, PTN and SHC1. Interacts withCBL, PIK3R1 and PLCG1 (By similarity)
Subcellular location: Cell membrane; Single-pass type I membrane protein. Note=Membrane attachment was crucial forpromotion of neuron-like differentiation and cell proliferation arrest through specific activation of the MAP kinasepathway
Sequence caution: Sequence=BAD92714.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
6/23 PDB 3D structures from  and Proteopedia  for ALK (see all 23):2KUP (3D)
2KUQ (3D)
2XB7 (3D)
2XBA (3D)
2XP2 (3D)
2YFX (3D)
Secondary accessions: Q4ZFX9 Q53QQ6 Q53RZ4 Q59FI3 Q9Y4K6Explore the universe of human proteins at neXtProt for ALK: NX_Q9UM73
Post-translational modifications:
Phosphorylated at tyrosine residues by autocatalysis, which activates kinase activity. In cells not stimulated by aligand, receptor protein tyrosine phosphatase beta and zeta complex (PTPRB/PTPRZ1) dephosphorylates ALK at the sitesin ALK that are undergoing autophosphorylation through autoactivation1
N-glycosylated1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UM73
4/5 DME Specific Peptides for ALK (Q9UM73) (see all 5)
ALK Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_004295.2
ENSEMBL proteins: ENSP00000373700 ENSP00000387488 ENSP00000414027
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table
ALK for ontologies About GeneDecksing
ALK Antibody Products:
Assay Products for ALK: |
Protein
Domains /
Families
for ALK gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ALK for domains About GeneDecksing
5/11 InterPro domains/families (see all 11):Graphical View of Domain Structure for InterPro Entry Q9UM73ProtoNet protein and cluster: Q9UM73 3 Blocks protein families: IPB002011 Receptor tyrosine kinase IPB002172 Low density lipoprotein-receptor IPB008266 Tyrosine protein kinase
UniProtKB/Swiss-Prot: ALK_HUMAN, Q9UM73Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamilySimilarity: Contains 1 LDL-receptor class A domainSimilarity: Contains 2 MAM domainsSimilarity: Contains 1 protein kinase domain |
Function
for ALK gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ALK_HUMAN, Q9UM73Function: Neuronal orphan receptor tyrosine kinase that is essentially and transiently expressed in specific regions ofthe central and peripheral nervous systems and plays an important role in the genesis and differentiation of thenervous system. Transduces signals from ligands at the cell surface, through specific activation of themitogen-activated protein kinase (MAPK) pathway. Phosphorylates almost exclusively at the first tyrosine of theY-x-x-x-Y-Y motif. Following activation by ligand, ALK induces tyrosine phosphorylation of CBL, FRS2, IRS1 and SHC1,as well as of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Acts as a receptor for ligands pleiotrophin (PTN), a secretedgrowth factor, and midkine (MDK), a PTN-related factor, thus participating in PTN and MDK signal transduction.PTN-binding induces MAPK pathway activation, which is important for the anti-apoptotic signaling of PTN and regulationof cell proliferation. MDK-binding induces phosphorylation of the ALK target insulin receptor substrate (IRS1),activates mitogen-activated protein kinases (MAPKs) and PI3-kinase, resulting also in cell proliferation induction.Drives NF-kappa-B activation, probably through IRS1 and the activation of the AKT serine/threonine kinase. Recruitmentof IRS1 to activated ALK and the activation of NF-kappa-B are essential for the autocrine growth and survivalsignaling of MDKCatalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphateEnzyme regulation: Activated by ligand-binding and subsequent phosphorylation. Inactivated through dephosphorylation byreceptor protein tyrosine phosphatase beta and zeta complex (PTPRB/PTPRZ1) when there is no stimulation by a ligand.Staurosporine, crizotinib and CH5424802 act as inhibitors of ALK kinase activity Genatlas biochemistry entry for ALK:anaplastic (CD30 + large cell) lymphoma kinase playing an important role in brain development,involved in anaplasticnodal non Hodgkin lymphoma or Hodgkin disease with translocation t(2;5)(p23;q35) or inv2(23;q35),see NPM1
Enzyme Number (IUBMB): EC 2.7.10.11 2
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ALK (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ALK
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ALK (NM_004304) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ALK | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALK |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALK |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
ALK for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for ALK:
Animal Models:
Mouse knock-out Alktm1Lex for ALK
1 MGI phenotypic allele  for Alk (no phenotypes)
ALK for phenotypes About GeneDecksing
|
Pathways & Interactions
for ALK gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/11 super-pathways (see all 11) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | GPCR Pathway | | | 2 | Rho Family GTPases | | | 3 | Nanog in Mammalian ESC Pluripotency | | | 4 | Actin Nucleation by ARP-WASP Complex | | | 5 | Akt Signaling | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/29 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ALK (see all 29)
1 
Cell Signaling Technology (CST) Pathway for ALK
ALK for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ALK
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/55 Interacting proteins for ALK (Q9UM731, 2, 3 ENSP000003737004) via UniProtKB, MINT, STRING, and/or I2D (see all 55)About this table
Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table
ALK for ontologies About GeneDecksing
|
Drugs & Compounds
for ALK gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
ALK for compounds About GeneDecksing
 Browse Tocris compounds for ALK
2 HMDB Compounds for ALK About this table
10/13 Novoseek chemical compound relationships for ALK gene (see all 13) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| [alcl] |
97.9 |
273 |
18549625 (6), 15713979 (5), 16114011 (5), 15291103 (4) (see all 86) |
| cltc |
90.3 |
15 |
17656252 (3), 12920229 (2), 12800156 (1), 11485898 (1) (see all 7) |
| tyrosine |
67.9 |
167 |
17681947 (4), 15226403 (4), 15938644 (3), 9174053 (3) (see all 82) |
| n-ipa |
59.5 |
5 |
12748172 (3), 16009132 (1), 16258267 (1) |
| 17-(allylamino)-17-demethoxygeldanamycin |
35.9 |
4 |
17157164 (2), 11888936 (1) |
| paraffin |
24.3 |
5 |
19147828 (1), 12594387 (1), 14626344 (1) |
| phosphatidylinositol |
10.9 |
1 |
11278720 (1) |
| doxorubicin |
10.3 |
2 |
14657946 (1), 17157164 (1) |
| phosphotyrosine |
7.79 |
4 |
18083107 (1), 14626344 (1), 17274988 (1) |
| alanine |
0 |
3 |
1354511 (1), 16249437 (1), 18421281 (1) |
1 PharmGKB related drug/compound annotation for ALK geneAbout this table
Search CenterWatch for drugs/clinical trials and news about ALK
|
Transcripts
for ALK gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ALK gene: NM_004304.4 Unigene Cluster for ALK: Anaplastic lymphoma receptor tyrosine kinase Hs.654469 [show with all ESTs]Unigene Representative Sequence: NM_0043044 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000389048(uc010ymo.2 uc002rmy.3) ENST00000453137 ENST00000498037
ENST00000431873
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ALK (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ALK
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ALK (NM_004304) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ALK | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALK |
Additional cDNA sequence: AB209477.4 AB600939.1 AB663645.1 AK296218.1 BX648960.1 FJ838786.1 FJ838787.1 GU797894.1 HQ993071.1 JQ828841.1 U62540.1 U66559.1 3 DOTS entries: DT.87014966 DT.101966450 DT.120998959 12 AceView cDNA sequences: BG211498 BX283500 BV183407 BQ448051 BE206076 AA309216 BE019506 BF306767 U66559 U62540 NM_004304 AF362886
GeneLoc Exon Structure
|
Expression
for ALK gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ALK expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See ALK Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ALK
SOURCE GeneReport for Unigene cluster: Hs.654469
UniProtKB/Swiss-Prot: ALK_HUMAN, Q9UM73Tissue specificity: Expressed in brain and CNS. Also expressed in the small intestine and testis, but not in normallymphoid cells
SABiosciences Expression via Pathway-Focused PCR Arrays including ALK:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ALK
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ALK | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ALK | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ALK | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALK |
Orthologs
for ALK gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ALK gene from 6/17 species (see all 17) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
ALK1 |
anaplastic lymphoma receptor tyrosine kinase |
72.31(n)
74.32(a) |
|
421297 XM_419364.3 XP_419364.3 |
lizard
(Anolis carolinensis) |
Reptilia |
ALK6 |
-- |
73(a) |
1 ↔ 1 |
1(248598457-248757216) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.302582 |
Xenopus laevis transcribed sequence with weak similarity more |
75.6(n) |
|
BG345730.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
ltk1 |
leukocyte tyrosine kinase |
55.94(n)
51.96(a) |
|
564470 NM_001006660.1 NP_001006661.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Alk1 , 3 |
protein amino acid phosphorylation protein
tyrosine more3
Alk1 |
33(a)3
46.72(n)1
38.07(a)1 |
|
53C103
534251 NM_144343.21 NP_652600.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
scd-23 |
protein kinase |
41(a)
(best of 3) |
|
V(6635869-6642021) -- |
ENSEMBL Gene Tree for ALK (if available)
TreeFam Gene Tree for ALK (if available) |
Paralogs
for ALK gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ALK gene
- INSR2 ROR12 ROS12 NTRK22 LTK2 IGF1R2 DDR12 NTRK32
- ROR22 INSRR2 DDR22 MUSK2 NTRK12
18/50 SIMAP similar genes for ALK using alignment to 30 protein entries: ALK_HUMAN (see all proteins)
(see all similar genes):DCTN1/ALK fusion EML4-ALK variant 7 KIF5B-ALK EML4-ALK PPFIBP1-ALK SQSTM1-ALK
EML4/ALK fusion TFG/ALK fusion EML4-ALK variant 6 EPHA4 tec BTK
LTK FLT4 MET ABL1 BTK kinase deficient isoform 6 DKFZp434L0319
ALK for paralogs About GeneDecksing
|
Genomic Variants
for ALK gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ALK (29415640 - 29665640 bp, first 250kb of ALK)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 21 variations for ALK
15/17 CNVs (see all 17): 9925 3348 67336 67323 89546 1569 32289 50458 89547 38895 89548 50459 8366 89545 2374
4 Indels: 10880 41743 60292 60291
Human Gene Mutation Database (HGMD): ALK
| 5/10 SABiosciences Cancer Mutation PCR Assays for ALK (see all 10): |
| 5 SABiosciences Cancer Mutation PCR Arrays containing ALK: |
| 2 SABiosciences qBiomarker Copy Number PCR Arrays containing ALK: |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ALK |
|
Disorders
/ Diseases
for ALK gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ALK for disorders About GeneDecksing
OMIM gene information: 105590
OMIM disorders: 613014
UniProtKB/Swiss-Prot: ALK_HUMAN, Q9UM73
Note=A chromosomal aberration involving ALK is found in a form of non-Hodgkin lymphoma. Translocationt(2;5)(p23;q35) with NPM1. The resulting chimeric NPM1-ALK protein homodimerize and the kinase becomes constitutivelyactivated. The constitutively active fusion proteins are responsible for 5-10% of non-Hodgkin lymphomas Note=A chromosomal aberration involving ALK is associated with inflammatory myofibroblastic tumors (IMTs).Translocation t(2;11)(p23;p15) with CARS; translocation t(2;4)(p23;q21) with SEC31A Note=A chromosomal aberration involving ALK is associated with anaplastic large-cell lymphoma (ALCL).Translocation t(2;17)(p23;q25) with ALO17 Defects in ALK are the cause of susceptibility to neuroblastoma type 3 (NBLST3) [MIM:613014]. Neuroblastoma isa common neoplasm of early childhood arising from embryonic cells that form the primitive neural crest and give riseto the adrenal medulla and the sympathetic nervous system Note=The ALK signaling pathway plays an important role in glioblastoma, the most common malignant brain tumorof adults and one of the most lethal cancers. It regulates both glioblastoma migration and growth
20/62  diseases for ALK (see all 62): About MalaCardsanaplastic large cell lymphoma lymphomatoid papulosis kyasanur forest disease neuroblastoma
malignant fibrous histiocytoma lung cancer fibrous histiocytoma diffuse large b-cell lymphoma
alk+ histiocytosis follicular dendritic cell tumor non-small cell lung carcinoma b-cell lymphomas
inflammatory myofibroblastic tumor non-hodgkin lymphoma soft tissue sarcoma histiocytoma
burkitt's lymphoma tracheal lymphoma neuroblastoma, susceptibility peripheral t-cell lymphoma
5 diseases from the University of Copenhagen DISEASES database for ALK:Lymphoma Reticulosarcoma Lung cancer Neuroblastoma
Carcinoma 10/49 Novoseek disease relationships for ALK gene (see all 49) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| anaplastic large cell lymphoma |
97.8 |
225 |
8866227 (2), 11215285 (2), 16434370 (2), 19135051 (2) (see all 99) |
| lymphoma large cell |
90.5 |
73 |
10886208 (2), 20227918 (2), 17332315 (2), 16189272 (2) (see all 35) |
| lymphoma |
89.9 |
830 |
19386350 (9), 9415224 (7), 7655001 (5), 10994999 (4) (see all 99) |
| lymphomatoid papulosis |
84.4 |
10 |
9415224 (2), 9638979 (1), 9250148 (1), 17325487 (1) (see all 5) |
| lymphoma t-cell peripheral |
80.5 |
1 |
9736036 (1) |
| hodgkin disease |
72.3 |
14 |
20227918 (2), 11697652 (2), 9638979 (1), 9490693 (1) (see all 10) |
| lymphoma non-hodgkins |
71.2 |
22 |
9174053 (2), 15938644 (1), 9121481 (1), 17694547 (1) (see all 12) |
| lymphoma b-cell |
71 |
40 |
17509395 (2), 18220322 (2), 10886208 (2), 12750159 (2) (see all 19) |
| pseudotumor inflammatory |
65 |
4 |
11395553 (3) |
| lymphoma t-cell |
64.8 |
15 |
16170336 (2), 11781220 (1), 12213716 (1), 18670314 (1) (see all 10) |
Genatlas disease: ALK nodal and extranodal,CD30+,anaplastic large-cell non Hodgkin's lymphoma,Hodgkin disease with translocationt(2;5)(p23;q35),infalmmatory myofibroblastic tumors
Human Genome Epidemiology (HuGE) Navigator: ALK (14 documents)
Tumor Gene Database (TGDB): ALK
Export disorders for ALK gene to outside databases
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Publications
for ALK gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ALK gene, integrated from 9 sources (see all 573):
(articles sorted by number of sources associating them with ALK) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma. (PubMed id 8122112)1, 2, 3, 9 Morris S.W.... Look A.T. (1994)
- Anaplastic lymphoma kinase is activated through the pleiotrophin/receptor protein-tyrosine phosphatase beta/zeta signaling pathway: an alternative mechanism of receptor tyrosine kinase activation. (PubMed id 17681947)1, 2, 9 Perez-Pinera P....Deuel T.F. (2007)
- Unique substrate specificity of anaplastic lymphoma kinase (ALK): development of phosphoacceptor peptides for the assay of ALK activity. (PubMed id 15938644)1, 2, 9 Donella-Deana A.... Pinna L.A. (2005)
- Molecular characterization of ALK, a receptor tyrosine kinase expressed specifically in the nervous system. (PubMed id 9053841)1, 2, 9 Iwahara T.... Yamamoto T. (1997)
- Identification of ALK as a major familial neuroblastoma predisposition gene. (PubMed id 18724359)1, 2, 9 Mosse Y.P....Maris J.M. (2008)
- Activating mutations in ALK provide a therapeutic target in neuroblastoma. (PubMed id 18923525)1, 2, 9 George R.E....Look A.T. (2008)
- Fusion of the SEC31L1 and ALK genes in an inflammatory myofibroblastic tumor. (PubMed id 16161041)1, 2, 9 Panagopoulos I.... Mandahl N. (2006)
- Midkine binds to anaplastic lymphoma kinase (ALK) and acts as a growth factor for different cell types. (PubMed id 12122009)1, 2, 9 Stoica G.E....Wellstein A. (2002)
- ALK receptor tyrosine kinase promotes cell growth and neurite outgrowth. (PubMed id 15226403)1, 2, 9 Motegi A....Yamamoto T. (2004)
- Pleiotrophin signaling through anaplastic lymphoma kinase is rate-limiting for glioblastoma growth. (PubMed id 11809760)1, 2, 9 Powers C....Wellstein A. (2002)
|
External Searches for ALK gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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|
|
Genome Databases showing ALK gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ALK gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ALK gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ALK | Pharmacogenomics, SNPs, Pathways | | ATLAS Chromosomes in Cancer entry for ALK | Genetics and Cytogenetics in Oncology and Haematology | | GeneReviews | http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/ALK |
|
| | |
About This Section
| Patent Information for ALK gene:
Search GeneIP for patents involving ALK
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ALK gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
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| | |  | OriGene Antibodies for ALK | | OriGene shRNA RFP for ALK | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ALK | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ALK | | | OriGene Protein Over-expression Lysate for ALK | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ALK | | OriGene 3'-UTR Clone for ALK | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ALK | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ALK | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for ALK | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ALK | | OriGene Custom Protein Services for ALK | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ALK | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ALK | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ALK | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ALK | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ALK | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ALK |
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