Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ALK Gene

Aliases for ALK Gene

  • Anaplastic Lymphoma Receptor Tyrosine Kinase 2 3
  • CD246 Antigen 3 4
  • EC 2.7.10.1 4 63
  • NBLST3 3 6
  • Anaplastic Lymphoma Kinase (Ki-1) 2
  • Mutant Anaplastic Lymphoma Kinase 3
  • ALK Tyrosine Kinase Receptor 3
  • Anaplastic Lymphoma Kinase 4
  • CD246 3

External Ids for ALK Gene

Previous GeneCards Identifiers for ALK Gene

  • GC02M029337
  • GC02M029508
  • GC02M029390
  • GC02M029327
  • GC02M029269

Summaries for ALK Gene

Entrez Gene Summary for ALK Gene

  • This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).[provided by RefSeq, Jan 2011]

GeneCards Summary for ALK Gene

ALK (Anaplastic Lymphoma Receptor Tyrosine Kinase) is a Protein Coding gene. Diseases associated with ALK include neuroblastoma 3 and inflammatory myofibroblastic tumor. Among its related pathways are GPCR Pathway and Akt Signaling. GO annotations related to this gene include protein tyrosine kinase activity and NF-kappaB-inducing kinase activity. An important paralog of this gene is LTK.

UniProtKB/Swiss-Prot for ALK Gene

  • Neuronal orphan receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system. Transduces signals from ligands at the cell surface, through specific activation of the mitogen-activated protein kinase (MAPK) pathway. Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif. Following activation by ligand, ALK induces tyrosine phosphorylation of CBL, FRS2, IRS1 and SHC1, as well as of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Acts as a receptor for ligands pleiotrophin (PTN), a secreted growth factor, and midkine (MDK), a PTN-related factor, thus participating in PTN and MDK signal transduction. PTN-binding induces MAPK pathway activation, which is important for the anti-apoptotic signaling of PTN and regulation of cell proliferation. MDK-binding induces phosphorylation of the ALK target insulin receptor substrate (IRS1), activates mitogen-activated protein kinases (MAPKs) and PI3-kinase, resulting also in cell proliferation induction. Drives NF-kappa-B activation, probably through IRS1 and the activation of the AKT serine/threonine kinase. Recruitment of IRS1 to activated ALK and the activation of NF-kappa-B are essential for the autocrine growth and survival signaling of MDK.

Gene Wiki entry for ALK Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ALK Gene

Genomics for ALK Gene

Regulatory Elements for ALK Gene

Genomic Location for ALK Gene

Start:
29,192,774 bp from pter
End:
29,921,611 bp from pter
Size:
728,838 bases
Orientation:
Minus strand

Genomic View for ALK Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ALK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ALK Gene

Proteins for ALK Gene

  • Protein details for ALK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UM73-ALK_HUMAN
    Recommended name:
    ALK tyrosine kinase receptor
    Protein Accession:
    Q9UM73
    Secondary Accessions:
    • Q4ZFX9
    • Q53QQ6
    • Q53RZ4
    • Q59FI3
    • Q9Y4K6

    Protein attributes for ALK Gene

    Size:
    1620 amino acids
    Molecular mass:
    176442 Da
    Quaternary structure:
    • Homodimer. Homodimerizes when bound to ligand. Interacts with FRS2, IRS1, MDK, PTN and SHC1. Interacts with CBL, PIK3R1 and PLCG1 (By similarity).
    SequenceCaution:
    • Sequence=BAD92714.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ALK Gene

neXtProt entry for ALK Gene

Proteomics data for ALK Gene at MOPED

Selected DME Specific Peptides for ALK Gene

Post-translational modifications for ALK Gene

  • N-glycosylated.
  • Phosphorylated at tyrosine residues by autocatalysis, which activates kinase activity. In cells not stimulated by a ligand, receptor protein tyrosine phosphatase beta and zeta complex (PTPRB/PTPRZ1) dephosphorylates ALK at the sites in ALK that are undergoing autophosphorylation through autoactivation. Phosphorylation at Tyr-1507 is critical for SHC1 association.
  • Glycosylation at Asn169, Asn244, Asn285, Asn324, Asn411, Asn424, Asn445, Asn563, Asn571, Asn627, Asn709, Asn808, Asn863, Asn864, Asn886, and Asn986
  • Modification sites at PhosphoSitePlus

Other Protein References for ALK Gene

Domains for ALK Gene

Graphical View of Domain Structure for InterPro Entry

Q9UM73

UniProtKB/Swiss-Prot:

ALK_HUMAN :
  • Q9UM73
Domain:
  • Contains 1 LDL-receptor class A domain.
  • Contains 2 MAM domains.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
genes like me logo Genes that share domains with ALK: view

Function for ALK Gene

Molecular function for ALK Gene

GENATLAS Biochemistry: anaplastic (CD30 + large cell) lymphoma kinase playing an important role in brain development,involved in anaplastic nodal non Hodgkin lymphoma or Hodgkin disease with translocation t(2;5)(p23;q35) or inv2(23;q35),see NPM1
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation: Activated by ligand-binding and subsequent phosphorylation. Inactivated through dephosphorylation by receptor protein tyrosine phosphatase beta and zeta complex (PTPRB/PTPRZ1) when there is no stimulation by a ligand. Staurosporine, crizotinib and CH5424802 act as inhibitors of ALK kinase activity.
UniProtKB/Swiss-Prot Function: Neuronal orphan receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system. Transduces signals from ligands at the cell surface, through specific activation of the mitogen-activated protein kinase (MAPK) pathway. Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif. Following activation by ligand, ALK induces tyrosine phosphorylation of CBL, FRS2, IRS1 and SHC1, as well as of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Acts as a receptor for ligands pleiotrophin (PTN), a secreted growth factor, and midkine (MDK), a PTN-related factor, thus participating in PTN and MDK signal transduction. PTN-binding induces MAPK pathway activation, which is important for the anti-apoptotic signaling of PTN and regulation of cell proliferation. MDK-binding induces phosphorylation of the ALK target insulin receptor substrate (IRS1), activates mitogen-activated protein kinases (MAPKs) and PI3-kinase, resulting also in cell proliferation induction. Drives NF-kappa-B activation, probably through IRS1 and the activation of the AKT serine/threonine kinase. Recruitment of IRS1 to activated ALK and the activation of NF-kappa-B are essential for the autocrine growth and survival signaling of MDK.

Enzyme Numbers (IUBMB) for ALK Gene

Gene Ontology (GO) - Molecular Function for ALK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004704 NF-kappaB-inducing kinase activity TAS 19459784
GO:0004713 protein tyrosine kinase activity IDA 9174053
GO:0004714 transmembrane receptor protein tyrosine kinase activity TAS 19459784
GO:0005515 protein binding IPI 17681947
genes like me logo Genes that share ontologies with ALK: view

Phenotypes for ALK Gene

GenomeRNAi human phenotypes for ALK:
genes like me logo Genes that share phenotypes with ALK: view

miRNA for ALK Gene

miRTarBase miRNAs that target ALK

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for ALK Gene

Localization for ALK Gene

Subcellular locations from UniProtKB/Swiss-Prot for ALK Gene

Cell membrane; Single-pass type I membrane protein. Note=Membrane attachment was crucial for promotion of neuron-like differentiation and cell proliferation arrest through specific activation of the MAP kinase pathway.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ALK Gene COMPARTMENTS Subcellular localization image for ALK gene
Compartment Confidence
plasma membrane 5
cytoskeleton 2
extracellular 2
nucleus 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for ALK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane TAS 19459784
GO:0016020 membrane --
GO:0043234 protein complex IDA 23382219
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with ALK: view

Pathways for ALK Gene

genes like me logo Genes that share pathways with ALK: view

Pathways by source for ALK Gene

1 Cell Signaling Technology pathway for ALK Gene
1 KEGG pathway for ALK Gene

Gene Ontology (GO) - Biological Process for ALK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity TAS 19459784
GO:0006468 protein phosphorylation --
GO:0007165 signal transduction TAS 19459784
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA --
GO:0007399 nervous system development --
genes like me logo Genes that share ontologies with ALK: view

Compounds for ALK Gene

(11) ApexBio Compounds for ALK Gene

Compound Action Cas Number
(R)-Crizotinib selective, ATP-competitive, small molecule tyrosine kinase inhibitor of c-Met and ALK. [877399-52-5]
AP26113 Dual inhibitor of anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR). [1197958-12-5]
ASP3026 a novel and selective inhibitor for the ALK kinase. [1097917-15-1]
AZD-3463 ALK/IGF1R inhibitor [1356962-20-3]
CH5424802 ATP-competitive inhibitor for ALK and L1196M [1256580-46-7]
GSK1838705A ATP-competitive inhibitor of IGF-IR and IR [1116235-97-2]
LDK378 Potent ALK inhibitor [1032900-25-6]
LDK378 dihydrochloride Potent ALK inhibitor [1380575-43-8]
LDN193189 Hydrochloride Potent and selective ALK inhibitor [1062368-62-0]
SB525334 Highly selective and ATP-competitive TGF-betaR1 (ALK5) inhibitor [356559-20-1]
TAE684 (NVP-TAE684) Potent and selective ALK inhibitor [761439-42-3]

(4) Tocris Compounds for ALK Gene

Compound Action Cas Number
ASP 3026 Potent anaplastic lymphoma kinase (ALK) inhibitor [1097917-15-1]
Crizotinib Potent c-MET/ALK inhibitor [877399-52-5]
GSK 1838705 Potent IR and IGF1R inhibitor; also inhibits anaplastic lymphoma kinase (ALK) [1116235-97-2]
KRCA 0008 Potent Ack1 and ALK dual inhibitor; orally bioavailable [1472795-20-2]

(2) HMDB Compounds for ALK Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0

(13) Novoseek inferred chemical compound relationships for ALK Gene

Compound -log(P) Hits PubMed IDs
[alcl] 97.9 156
cltc 90.3 10
tyrosine 67.9 100
n-ipa 59.5 5
17-(allylamino)-17-demethoxygeldanamycin 35.9 3

(1) PharmGKB related drug/compound annotations for ALK Gene

Drug/compound Annotation
crizotinib
genes like me logo Genes that share compounds with ALK: view

Transcripts for ALK Gene

mRNA/cDNA for ALK Gene

(12) Selected AceView cDNA sequences:
(13) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ALK Gene

Anaplastic lymphoma receptor tyrosine kinase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ALK Gene

No ASD Table

Relevant External Links for ALK Gene

GeneLoc Exon Structure for
ALK
ECgene alternative splicing isoforms for
ALK

Expression for ALK Gene

mRNA expression in normal human tissues for ALK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ALK Gene

This gene is overexpressed in Pituitary (6.4) and Brain - Hypothalamus (5.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ALK Gene

SOURCE GeneReport for Unigene cluster for ALK Gene Hs.654469

mRNA Expression by UniProt/SwissProt for ALK Gene

Q9UM73-ALK_HUMAN
Tissue specificity: Expressed in brain and CNS. Also expressed in the small intestine and testis, but not in normal lymphoid cells.
genes like me logo Genes that share expressions with ALK: view

Orthologs for ALK Gene

This gene was present in the common ancestor of animals.

Orthologs for ALK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ALK 35
  • 97.77 (n)
  • 96.99 (a)
ALK 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ALK 36
  • 90 (a)
OneToOne
LOC536642 35
  • 87.89 (n)
  • 90.61 (a)
dog
(Canis familiaris)
Mammalia ALK 35
  • 89.8 (n)
  • 92.51 (a)
ALK 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Alk 35
  • 84.79 (n)
  • 88.38 (a)
Alk 16
Alk 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ALK 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ALK 36
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Alk 35
  • 85.27 (n)
  • 88.88 (a)
chicken
(Gallus gallus)
Aves ALK 35
  • 72.08 (n)
  • 74.25 (a)
ALK 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ALK 36
  • 72 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.30258 35
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495071 35
  • 64.46 (n)
  • 62.08 (a)
zebrafish
(Danio rerio)
Actinopterygii alk 35
  • 61.65 (n)
  • 60.57 (a)
alk 36
  • 51 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Alk 36
  • 25 (a)
OneToMany
Alk 37
  • 33 (a)
worm
(Caenorhabditis elegans)
Secernentea scd-2 36
  • 20 (a)
OneToMany
T25B9.5 37
  • 28 (a)
F09A5.2 37
  • 34 (a)
scd-2 37
  • 41 (a)
Species with no ortholog for ALK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ALK Gene

ENSEMBL:
Gene Tree for ALK (if available)
TreeFam:
Gene Tree for ALK (if available)

Paralogs for ALK Gene

Paralogs for ALK Gene

genes like me logo Genes that share paralogs with ALK: view

Variants for ALK Gene

Sequence variations from dbSNP and Humsavar for ALK Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs3634 -- 29,540,250(-) GTCAG(A/G)AAGTG intron-variant
rs25590 -- 29,755,081(+) CTAAG(-/A/AG)GGTAC intron-variant
rs747148 -- 29,749,812(-) AAATT(G/T)GGGGA intron-variant
rs763836 -- 29,682,438(+) TATAA(C/T)CTGTG intron-variant
rs872674 -- 29,726,750(-) AAGTC(A/G)TGGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ALK Gene

Variant ID Type Subtype PubMed ID
dgv1163e1 CNV Complex 17122850
esv34904 CNV Gain 17911159
nsv438237 CNV Loss 16468122
nsv455997 CNV Loss 19166990
esv2719856 CNV Deletion 23290073
nsv524336 CNV Loss 19592680
esv2678336 CNV Deletion 23128226
nsv525718 CNV Loss 19592680
nsv456008 CNV Loss 19166990
dgv4073n71 CNV Loss 21882294
nsv438248 CNV Loss 16468122
nsv9480 CNV Loss 18304495
esv2663423 CNV Deletion 23128226
esv23879 CNV Loss 19812545
nsv817706 CNV Loss 17921354
esv2421745 CNV Deletion 20811451
nsv515557 CNV Loss 19592680
nsv441750 CNV CNV 18776908
nsv514056 CNV Loss 21397061
esv271348 CNV Insertion 20981092
esv2671680 CNV Deletion 23128226
esv271041 CNV Insertion 20981092
esv274310 CNV Insertion 20981092
esv2675184 CNV Deletion 23128226
nsv2659 CNV Insertion 18451855
nsv433197 CNV Loss 18776910
esv990532 CNV Insertion 20482838
esv1191389 CNV Insertion 17803354
nsv833636 CNV Gain 17160897
nsv2660 CNV Insertion 18451855
esv2667588 CNV Deletion 23128226
esv29115 CNV Loss 19812545
esv8173 CNV Gain 19470904
esv2719857 CNV Deletion 23290073
esv4149 CNV Deletion 18987735
esv2719858 CNV Deletion 23290073
nsv471776 CNV Loss 16327809
esv1273908 CNV Deletion 17803354
nsv2661 CNV Loss 18451855
esv270240 CNV Insertion 20981092

Relevant External Links for ALK Gene

HapMap Linkage Disequilibrium report
ALK
Human Gene Mutation Database (HGMD)
ALK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ALK Gene

Disorders for ALK Gene

(1) OMIM Diseases for ALK Gene (105590)

UniProtKB/Swiss-Prot

ALK_HUMAN
  • Note=A chromosomal aberration involving ALK is found in a form of non-Hodgkin lymphoma. Translocation t(2;5)(p23;q35) with NPM1. The resulting chimeric NPM1-ALK protein homodimerize and the kinase becomes constitutively activated. The constitutively active fusion proteins are responsible for 5-10% of non-Hodgkin lymphomas.
  • Note=A chromosomal aberration involving ALK is associated with inflammatory myofibroblastic tumors (IMTs). Translocation t(2;11)(p23;p15) with CARS; translocation t(2;4)(p23;q21) with SEC31A.
  • Note=A chromosomal aberration involving ALK is associated with anaplastic large-cell lymphoma (ALCL). Translocation t(2;17)(p23;q25) with ALO17.
  • Neuroblastoma 3 (NBLST3) [MIM:613014]: A common neoplasm of early childhood arising from embryonic cells that form the primitive neural crest and give rise to the adrenal medulla and the sympathetic nervous system. {ECO:0000269 PubMed:18724359, ECO:0000269 PubMed:18923523, ECO:0000269 PubMed:18923525}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
  • Note=The ALK signaling pathway plays an important role in glioblastoma, the most common malignant brain tumor of adults and one of the most lethal cancers. It regulates both glioblastoma migration and growth.

(5) University of Copenhagen DISEASES for ALK Gene

(49) Novoseek inferred disease relationships for ALK Gene

Disease -log(P) Hits PubMed IDs
anaplastic large cell lymphoma 97.8 115
lymphoma large cell 90.5 41
lymphoma 89.9 207
lymphomatoid papulosis 84.4 6
lymphoma t-cell peripheral 80.5 1

Genatlas disease for ALK Gene

nodal and extranodal,CD30+,anaplastic large-cell non Hodgkins lymphoma,Hodgkin disease with translocation t(2;5)(p23;q35),infalmmatory myofibroblastic tumors

Relevant External Links for ALK

Genetic Association Database (GAD)
ALK
Human Genome Epidemiology (HuGE) Navigator
ALK
Tumor Gene Database (TGDB):
ALK
genes like me logo Genes that share disorders with ALK: view

Publications for ALK Gene

  1. Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma. (PMID: 8122112) Morris S.W. … Look A.T. (Science 1994) 2 3 4 23
  2. ALK, the chromosome 2 gene locus altered by the t(2;5) in non- Hodgkin's lymphoma, encodes a novel neural receptor tyrosine kinase that is highly related to leukocyte tyrosine kinase (LTK). (PMID: 9174053) Morris S.W. … Witte D.P. (Oncogene 1997) 3 4 23
  3. The cytoplasmic truncated receptor tyrosine kinase ALK homodimer immortalizes and cooperates with ras in cellular transformation. (PMID: 11387242) Simonitsch I. … Cerni C. (FASEB J. 2001) 3 4 23
  4. Molecular characterization of ALK, a receptor tyrosine kinase expressed specifically in the nervous system. (PMID: 9053841) Iwahara T. … Yamamoto T. (Oncogene 1997) 3 4 23
  5. Identification of anaplastic lymphoma kinase as a receptor for the growth factor pleiotrophin. (PMID: 11278720) Stoica G.E. … Wellstein A. (J. Biol. Chem. 2001) 3 4 23

Products for ALK Gene

  • Addgene plasmids for ALK

Sources for ALK Gene

Back to Top

Content