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ALK Gene

protein-coding   GIFtS: 64

GC02M029327
anaplastic lymphoma receptor tyrosine kinase
(Previous name: anaplastic lymphoma kinase (Ki-1) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
"" "" "" "" "" "" "" "" "" "" "" "" "" "" "" ""Services    
"" "" "" "" "" "" "" "" "" "" "" "" ""
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases & Descriptions
anaplastic lymphoma receptor tyrosine kinase1 2     anaplastic lymphoma kinase (Ki-1)1
CD2461 2     TFG/ALK2
Anaplastic lymphoma kinase2 3     ALK tyrosine kinase receptor2
CD246 antigen2 3     EC 2.7.10.13
NBLST32 5     

External Ids:    HGNC: 4271   Entrez Gene: 2382   Ensembl: ENSG000001710947   UniProtKB: Q9UM733   

Search outside databases for aliases for ALK gene

Previous GC identifers: GC02M029337 GC02M029508 GC02M029390 GC02M029269

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ALK:
The 2;5 chromosomal translocation is frequently associated with anaplastic large cell lymphomas (ALCLs). The
translocation creates a fusion gene consisting of the ALK (anaplastic lymphoma kinase) gene and the nucleophosmin
(NPM) gene: the 3' half of ALK, derived from chromosome 2, is fused to the 5' portion of NPM from chromosome
5. A recent study shows that the product of the NPM-ALK fusion gene is oncogenic. The deduced amino acid sequences
reveal that ALK is a novel receptor protein-tyrosine kinase having a putative transmembrane domain and an
extracellular domain. These sequences are absent in the product of the transforming NPM-ALK gene. ALK shows the
greatest sequence similarity to LTK (leukocyte tyrosine kinase). ALK plays an important role in the development of the
brain and exerts its effects on specific neurons in the nervous system. (provided by RefSeq)

UniProtKB/Swiss-Prot: ALK_HUMAN, Q9UM73
Function: Orphan receptor with a tyrosine-protein kinase activity. Appears to play an important role in the normal
development and function of the nervous system. Phosphorylates almost exclusively at the first tyrosine of the
Y-x-x-x-Y-Y motif

Gene Wiki entry for ALK (Anaplastic lymphoma kinase)
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC and Ensembl (release 56), Regulatory elements and Epigenetics data according to SABiosciences)
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Regulatory elements:
"" SABiosciences Regulatory transcription factor binding sites in the ALK gene upstream (promoter) region "":
NRSF form 2   NRSF form 1   C/EBPbeta   CUTL1   AP-1   STAT3   p53   c-Myb   ZID   c-Rel   

Epigenetics:
"" SABiosciences Methyl-Profiler DNA Methylation qPCR Primer Assays for ALK:  ""
MePH02879-3A   

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p23   Ensembl cytogenetic band:  2p23.1   HGNC cytogenetic band: 2p23

ALK Gene in genomic location: bands according to Ensembl, locations according to "" (and/or Entrez Gene and/or Ensembl if different)
""

GeneLoc gene densities for chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M029327:  view genomic region     (about GC identifiers)

Start:
29,415,640 bp from pter
End:
30,144,432 bp from pter
Size:
728,793 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000002.11  NT_022184.15  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene, Novus Biologicals, and/or Sino Biological,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 May 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abnova, OriGene, Novus Biologicals, and/or Epitomics)
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UniProtKB/Swiss-Prot: ALK_HUMAN, Q9UM73 (See protein sequence)
Recommended Name: ALK tyrosine kinase receptor precursor  
Size: 1620 amino acids; 176428 Da
Subunit: Homodimer. When bound to ligand
Subcellular location: Membrane; Single-pass type I membrane protein
Sequence caution: Sequence=BAD92714.1; Type=Erroneous initiation;
PDB structure from "" and Proteopedia "" :
2YS5 (3D) ""    2YT2 (3D) ""    
Secondary accessions: Q4ZFX9 Q53QQ6 Q53RZ4 Q59FI3 Q9Y4K6

Post-translational modifications:

  • N-glycosylated1
  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_004295.2  

    ENSEMBL proteins: 
    ENSP00000403741 ENSP00000403217 ENSP00000399568 ENSP00000414027 ENSP00000387488 ENSP00000373700 


    Human Recombinant Proteins 
    ""Millipore Purified and/or Recombinant ALK Protein
    ""Browse Human Recombinant Proteins at Sigma-Aldrich
    "" Browse R&D Systems for human recombinant proteins
    ""Browse recombinant and purified proteins available from Enzo Life Sciences
    ""HuPro® and/or Recombinant Proteins from Abnova for ALK ""
    ""Browse Origene full length recombinant human proteins expressed in human HEK293 cells
    ""Novus Biologicals Protein for ALK  ""
    ""Browse Sino Biological Recombinant Proteins  ""

    2 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887 integral to plasma membrane IDA9174053
    GO:0016020 membrane IEA--
    About this table

    "" ALK for ontologies           About GeneDecksing



    Antibodies for ALK: 
    ""Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    ""Sigma-Aldrich Antibodies for ALK
    ""R&D Systems Antibodies for ALK (ALK/CD246)
    ""Cell Signaling Technology (CST) Antibodies for ALK 
    ""Browse Abnova for Monoclonal and Polyclonal Antibodies
    "" Origene Antibodies: ALK ""
    ""Novus Biologicals Antibodies for ALK
    ""Epitomics antibodies for ALK

    Assays for ALK: 
    ""Browse Kits and Assays available from Millipore
    ""Browse ELISAs at Sigma-Aldrich
    "" Browse R&D Systems for biochemical assays
    ""Cell Signaling Technology (CST) Sandwich ELISA Kits for ALK
    ""Browse Enzo Life Sciences for kits & assays

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

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    "" ALK for domains           About GeneDecksing

    5/10 InterPro domains/families (see all 10 ):
     IPR017441 Protein_kinase_ATP_BS
     IPR011009 Kinase-like_dom
     IPR002011 Tyr_prot_kinase_rcpt_2_CS
     IPR000719 Prot_kinase_cat_dom
     IPR002172 LDL_rcpt_classA_cys-rich_rpt

    Graphical View of Domain Structure for InterPro Entry Q9UM73

    ProtoNet protein and cluster: Q9UM73

    3 Blocks protein families:
    IPB002011 Receptor tyrosine kinase
    IPB002172 Low density lipoprotein-receptor
    IPB008266 Tyrosine protein kinase


    UniProtKB/Swiss-Prot: ALK_HUMAN, Q9UM73
    Similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily
    Similarity: Contains 1 LDL-receptor class A domain
    Similarity: Contains 2 MAM domains
    Similarity: Contains 1 protein kinase domain

    (According to MGI May 08 2010, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, Abnova, siRNAs from Applied Biosystems, Sigma-Aldrich, Clones from Millipore, Sigma-Aldrich, OriGene, Sino Biological, Ontologies according to Gene Ontology Consortium 01 May 2010 via Entrez Gene.)
    About This Section

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    Inhib.
    RNA:
    ""Browse for Gene Knock-down Tools from Millipore
    ""Abnova Chimera RNAi Products for Gene knock-down (ALK)
    "" Origene 29mer shRNA kits in GFP-retroviral vector: ALK
    Origene shRNA RFP: ALK
    Origene basic RS shRNA: ALK

    ""Applied Biosystems Silencer® siRNAs for ALK
    ""Sigma-Aldrich siRNA Panels and siRNA for ALK
    Sigma-Aldrich shRNA Panels and shRNA for ALK
    Explore Sigma-Aldrich super-pooled esiRNAs
    Clones:""Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    ""Browse iPSC Reprogramming Factors at Sigma-Aldrich
    "" Origene GFP tagged cDNA clones in CMV expression vector: ALK
    Origene Myc/DDK tagged cDNA clones in CMV expression vector: ALK
    Origene untagged cDNA clones in CMV expression vector: ALK
    ""Browse Sino Biological Human cDNA Clones  ""

    UniProtKB/Swiss-Prot: ALK_HUMAN, Q9UM73
    Function: Orphan receptor with a tyrosine-protein kinase activity. Appears to play an important role in the normal
    development and function of the nervous system. Phosphorylates almost exclusively at the first tyrosine of the
    Y-x-x-x-Y-Y motif
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
    Enzyme Number (IUBMB): EC 2.7.10.1 

    Genatlas biochemistry entry for ALK:
    anaplastic (CD30 + large cell) lymphoma kinase playing an important role in brain development,involved in anaplastic
    nodal non Hodgkin lymphoma or Hodgkin disease with translocation t(2;5)(p23;q35) or inv2(23;q35),see NPM1

    5/10 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 10 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166 nucleotide binding IEA--
    GO:0004672 protein kinase activity ----
    GO:0004674 protein serine/threonine kinase activity ----
    GO:0004713 protein tyrosine kinase activity ----
    GO:0004714 transmembrane receptor protein tyrosine kinase activity IDA9174053
    About this table

    "" ALK for ontologies           About GeneDecksing

    Animal Models: 1 MGI phenotypic allele "" for Alk (no phenotypes)


    "" ALK for phenotypes           About GeneDecksing

    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, Applied Biosystems GeneAssist, KEGG and/or UniProtKB, (map by GeneGo),
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 May 2010 via Entrez Gene).
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    "" ALK for pathways           About GeneDecksing

    5/30 "" GeneAssist Pathways for ALK (see all 30 )
      ""  Estrogen Pathway
    Nanog in Mammalian ESC Pluripotency
    Activation of cAMP-Dependent PKA
    Paxillin Interactions
    MAPK Signaling

    2 "" Cell Signaling Technology (CST) Pathways for ALK: 
      ""  Translational Control: Regulation of eIF4E and p70 S6 Kinase
    Protein Acetylation

    "" SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ALK

    5/8 Interacting proteins for ALK (ENSP000003737003 Q9UM731, 2) via UniProtKB, MINT, and/or STRING (see all 8 ""
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTPRBP234671EBI-357361,EBI-1265766
    PTPRGP234701EBI-357361,EBI-2258115
    PTPRJQ129131EBI-357361,EBI-2264500
    MAP3K3Q997592MINT-48477
    PTNENSP000003411703STRING: ENSP00000341170
    About this table

    5/7 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 7 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468 protein amino acid phosphorylation ----
    GO:0006487 protein amino acid N-linked glycosylation ----
    GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA--
    GO:0007399 nervous system development IEA--
    GO:0007420 brain development ----
    About this table

    "" ALK for ontologies           About GeneDecksing


    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

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    "" ALK for compounds           About GeneDecksing

    "" Browse drugs & compounds from Enzo Life Sciences
    ""Browse Small Molecules at Sigma-Aldrich

    "" Browse Tocris compounds for ALK
    10/56 ""Novoseek chemical compound relationships for ALK gene (see all 56 )
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 65.22 153 18070884 (4), 17681947 (4), 15226403 (4), 9174053 (3) (see all 100)
    [alcl] 61.17 25 16955462 (5), 15161657 (4), 16939498 (3), 16361803 (2) (see all 13)
    17-(allylamino)-17-demethoxygeldanamycin 11.76 9 11888936 (5), 17157164 (4)
    phosphotyrosine 5.67 9 14626344 (4), 10398126 (4), 17274988 (1)
    chlortetracycline 5.55 8 17656252 (3), 19545284 (1), 15852431 (1), 12800156 (1) (see all 6)
    citiolone 3.74 2 3031268 (2)
    propafenone 3.10 5 1354511 (5)
    wortmannin 2.02 5 11110708 (2), 15226403 (1), 12748172 (1), 11280786 (1)
    cucurbitacin i 1.99 1 16939498 (1)
    ly293111 1.76 1 16151469 (1)
    About this table


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 223 Homo sapiens; Apr 2 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Primers from OriGene and/or SABiosciences,
    Expression Assays from Applied Biosystems)
    About This Section

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    Inhib.
    RNA:
    ""Browse for Gene Knock-down Tools from Millipore
    ""Abnova Chimera RNAi Products for Gene knock-down (ALK)
    ""Applied Biosystems Silencer® siRNAs:  NM_004304  
    "" Origene 29mer shRNA kits in GFP-retroviral vector: ALK
    Origene shRNA RFP: ALK
    Origene basic RS shRNA: ALK

    ""Sigma-Aldrich siRNA Panels and siRNA for ALK
    Sigma-Aldrich shRNA Panels and shRNA for ALK
    Explore Sigma-Aldrich super-pooled esiRNAs

    microRNA:""1 SABiosciences microRNA that regulate ALK""
    hsa-miR-96
    Assays:  ""Applied Biosystems TaqMan® Gene Expression Assays:  
    NM_004304  


    Clones:"" Origene GFP tagged cDNA clones in CMV expression vector: ALK
    Origene Myc/DDK tagged cDNA clones in CMV expression vector: ALK
    Origene untagged cDNA clones in CMV expression vector: ALK
    Primers:"" Origene genome-wide validated SYBR primer pairs: ALK
    ""SABiosciences RT2 qPCR Primer Assay for ALK: PPH19510A ""

    REFSEQ mRNAs for ALK gene: 

    NM_004304.3  

    Additional cDNA sequence: 

    AB209477.3 AB462411.1 AF125093.1 AK296218.1 BX648960.1 U62540.1 U66559.1 

    3 DOTS entries:

    DT.87014966  DT.101966450  DT.120998959 

    12 AceView cDNA sequences:

    BG211498 BQ448051 BX283500 BE206076 BV183407 BF306767 AA309216 BE019506 
    U66559 NM_004304 U62540 AF362886 

    "" highest scoring ESTs for ALK:

    U62540 U66559 AL525617 BE019506 BG211498 BX348694 BX366032 NM_004304 AA309216 BE206076 

    Unigene Cluster for ALK:

    Anaplastic lymphoma receptor tyrosine kinase
    Hs.654469  [show with all ESTs]
    Unigene Representative Sequence: U62540


    GeneLoc Exon Structure

    7 Ensembl transcripts including schematic representations:
    ENST00000442523  ENST00000438993  ENST00000415678  ENST00000431873  ENST00000498037  ENST00000453137  
    ENST00000389048  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 223 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems, Primers from OriGene and/or SABiosciences )
    About This Section

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    ALK expression in normal and diseased human tissues

    "" Applied Biosystems TaqMan ® Gene Expression Assays for ALK

    1""  / 2""  / 3""

    6 probe-sets matching ALK gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    38543_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 U62540 1.00 0.90 0.95 1
    451_at2, 3 U95-A 1 0.94 1.00 0.80 1.03 U66559 1.00 0.90 0.95 1
    208211_s_at2, 3 U133-A 1 1.00 1.00 -- -- U66559 1.00 0.90 0.95 1
    208212_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_004304 0.60 1.00 0.82 1
    208211_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    208212_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table

    "" ALK for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene cluster: Hs.654469

    Expression variation in blood from EXPOLDB for ALK

    UniProtKB/Swiss-Prot: ALK_HUMAN, Q9UM73
    Tissue specificity: Expressed in brain and CNS. Also expressed in the small intestine and testis, but not in normal
    lymphoid cells

    Primers:"" Origene genome-wide validated SYBR primer pairs: ALK ""
    ""SABiosciences RT2 qPCR Primer Assay for ALK: PPH19510A ""
    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI May 08 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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    Orthologs for ALK gene from 5/8 species (see all 8 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    ALK1   -- anaplastic lymphoma receptor tyrosine kinase 89.78(n)
    92.41(a)
    483021  XM_540136.2  XP_540136.2 
    cow
    (Bos taurus)
    ALK1   -- anaplastic lymphoma receptor tyrosine kinase 87.52(n)
    90.14(a)
    536642  XM_616782.3  XP_616782.3 
    mouse
    (Mus musculus)
    Alk1, 5 17 (50.00 cM)5
    anaplastic lymphoma kinase1, 5 84.77(n)1
    88.38(a)1
    116821  NM_007439.21  NP_031465.21 
     AK0513585  AK1587635  (see all 11)
    chicken
    (Gallus gallus)
    ALK1   -- anaplastic lymphoma kinase (Ki-1) 71.45(n)
    72.45(a)
    421297  XM_419364.2  XP_419364.2 
    zebrafish
    (Danio rerio)
    alk1   -- anaplastic lymphoma kinase (Ki-1) 59.86(n)
    57.18(a)
    563509  XM_686872.2  XP_691964.2 
    About this table        Species with no ortholog for ALK

    ENSEMBL Gene Tree for ALK
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
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    Paralogs for ALK gene
    INSR2  LTK2  PTK72  INSRR2  ROR22  NTRK32  DDR22  LMTK22  
    MUSK2  LMTK32  NTRK12  ROR12  NTRK22  ROS12  IGF1R2  AATK2  
    DDR12  

    "" ALK for paralogs           About GeneDecksing


    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Genotyping Reagents from Applied Biosystems)
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    10/1331 NCBI SNPs in ALK are shown (see all 1331 )
    (Click "" for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 1669)
    ABGenomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 2 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    ""
    rs22935641,2
    C,F,O,A,H29543663(-) CCTCAA/C/G/
            
    TGGCA
    4 Q H ref1 mis1 syn1 ese3""17""EA NA NS WA 2634""
    ""
    rs18814211,2
    C,F,O,A,H29416366(-) CACGAG/CAGGGG 2 /D /E ref1 mis1 ese3""25Minor allele frequency- C:0.37MN NS EA NA WA 3482""
    ""
    rs18814201,2
    C,F,O,A29416481(-) GCACAA/C/G/
            
    GGTCC
    4 K T R M ref1 mis1 ese3""26""MN NA EA NS 3669""
    ""
    rs46180001,2
    C,F,A,H29884878(+) ATCCTC/TAGACA 1 -- ng51""10Minor allele frequency- T:0.44NS EA NA WA 632""
    ""
    rs67484391,2
    C,F,A29884584(+) AATACA/CTTTCA 1 -- ng51""11Minor allele frequency- N:0.00NS EA NA WA 834""
    ""
    rs16702831,2
    C,F,H29416572(+) AGAGAA/C/G/
            
    CTCTG
    4 I L V F ref1 mis1 ese3""13""MN NS EA NA 1022""
    ""
    rs17288281,2
    C,F,H29415792(-) TCTTTT/CAAATT 1 -- ut31""13Minor allele frequency- C:0.01MN NA NS EA WA 804""
    ""
    rs75979811,2
    A,H29885357(+) ATATGC/TTCCTA 1 -- ng51""4Minor allele frequency- T:0.00NS EA 418""
    ""
    rs75738261,2
    A,H29885807(+) TAAATG/CACACT 1 -- ng51""4Minor allele frequency- C:0.00NS EA 418""
    ""
    rs18814221,2
    C,F29416357(-) GGTAAA/C/G/
            
    CTGGG
    4 K N mis1 ref1 syn1""6""MN NS EA WA 628""
    About this table

    HapMap Linkage Disequilibrium images for ALK (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)  ""
    Database of Genomic Variants (DGV): 21 variations for ALK
         15/17 CNVs (see all 17 ): 9925 3348 67336 67323 89546 1569 32289 50458 89547 38895 89548 50459 8366 89545 2374
         4 Indels: 10880 41743 60292 60291

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

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    "" ALK for disorders           About GeneDecksing

    OMIM: 105590   disorders: 613014  

    UniProtKB/Swiss-Prot: ALK_HUMAN, Q9UM73

  • A chromosomal aberration involving ALK is found in a form of non-Hodgkin lymphoma. Translocation
  • t(2;5)(p23;q35) with NPM1. The resulting chimeric NPM1-ALK protein homodimerize and the kinase becomes constitutively
    activated. The constitutively active fusion proteins are responsible for 5-10% of non-Hodgkin lymphomas
  • A chromosomal aberration involving ALK is associated with inflammatory myofibroblastic tumors (IMTs).
  • Translocation t(2;11)(p23;p15) with CARS; translocation t(2;4)(p23;q21) with SEC31A
  • A chromosomal aberration involving ALK is associated with anaplastic large-cell lymphoma (ALCL). Translocation
  • t(2;17)(p23;q25) with ALO17

    10/176 ""Novoseek disease relationships for ALK gene (see all 176 )

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    lymphoma 100.00 176 15475930 (7), 10552961 (7), 10194450 (7), 9415224 (6) (see all 100)
    anaplastic large cell lymphoma 100.00 595 16784988 (9), 20159827 (8), 16084951 (8), 11395396 (8) (see all 100)
    inflammatory myofibroblastic tumor 100.00 111 17396140 (7), 12594387 (6), 15188137 (5), 16984614 (4) (see all 56)
    anaplastic lymphoma 100.00 493 19386350 (9), 10505771 (4), 18788887 (3), 15887977 (3) (see all 100)
    alk-positive anaplastic large cell lymphoma 79.40 27 14626344 (5), 16955462 (4), 19951975 (3), 10552961 (2) (see all 17)
    gene fusion 60.99 55 20183914 (5), 10994999 (4), 11395396 (3), 9500471 (2) (see all 39)
    dlbcl 57.89 60 18755494 (5), 12763927 (5), 19636007 (4), 18458503 (4) (see all 29)
    t(2; 5) 47.66 17 9844824 (1), 9643564 (1), 9490693 (1), 9174053 (1) (see all 17)
    neuroblastoma 32.66 59 15972965 (6), 19723661 (4), 19656550 (4), 18923525 (4) (see all 32)
    lymphoma, t-cell 18.28 22 20159827 (3), 16170336 (2), 11097375 (2), 2163351 (1) (see all 18)
    About this table

    Genatlas disease: ALK
    nodal and extranodal,CD30+,anaplastic large-cell non Hodgkin's lymphoma,Hodgkin disease with translocation
    t(2;5)(p23;q35),infalmmatory myofibroblastic tumors

    Human Gene Mutation Database: ALK
    Human Genome Epidemiology Navigator: ALK (7 documents)
    Tumor Gene Database: ALK

    (Possibly Related Articles in Doctor's Guide)
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    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
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    10/427 PubMed articles for ALK gene (see all 427 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 238 HGNC: 427 AceView: ALK Ensembl:ENSG00000171094 euGenes: HUgn238
    ECgene: ALK H-InvDB: ALK
    (According to HUGE)
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    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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    NameDescription
    ATLAS Chromosomes in Cancer entry for ALK Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/ALK
    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
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    Patent Information for ALK gene: ""
    Search GeneIP for patents involving ALK

    GeneCards and IP: ""
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search


    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Novus Biologicals,
    Epitomics, Sigma-Aldrich, R&D Systems, SABiosciences, Millipore, Abnova,
    Clones available from OriGene, Sigma-Aldrich, Sino Biological, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience)
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    ""
    ""
    Products for ALK:
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