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Aliases for ALK Gene

Aliases for ALK Gene

  • Anaplastic Lymphoma Receptor Tyrosine Kinase 2 3 5
  • CD246 Antigen 3 4
  • EC 2.7.10.1 4 63
  • Anaplastic Lymphoma Kinase (Ki-1) 2
  • Mutant Anaplastic Lymphoma Kinase 3
  • Anaplastic Lymphoma Kinase 4
  • NBLST3 3
  • CD246 3

External Ids for ALK Gene

Previous GeneCards Identifiers for ALK Gene

  • GC02M029337
  • GC02M029508
  • GC02M029390
  • GC02M029327
  • GC02M029269

Summaries for ALK Gene

Entrez Gene Summary for ALK Gene

  • This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).[provided by RefSeq, Jan 2011]

GeneCards Summary for ALK Gene

ALK (Anaplastic Lymphoma Receptor Tyrosine Kinase) is a Protein Coding gene. Diseases associated with ALK include neuroblastoma 3 and inflammatory myofibroblastic tumor. Among its related pathways are ERK Signaling and Akt Signaling. GO annotations related to this gene include identical protein binding and protein kinase activity. An important paralog of this gene is DDR1.

UniProtKB/Swiss-Prot for ALK Gene

  • Neuronal orphan receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system. Transduces signals from ligands at the cell surface, through specific activation of the mitogen-activated protein kinase (MAPK) pathway. Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif. Following activation by ligand, ALK induces tyrosine phosphorylation of CBL, FRS2, IRS1 and SHC1, as well as of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Acts as a receptor for ligands pleiotrophin (PTN), a secreted growth factor, and midkine (MDK), a PTN-related factor, thus participating in PTN and MDK signal transduction. PTN-binding induces MAPK pathway activation, which is important for the anti-apoptotic signaling of PTN and regulation of cell proliferation. MDK-binding induces phosphorylation of the ALK target insulin receptor substrate (IRS1), activates mitogen-activated protein kinases (MAPKs) and PI3-kinase, resulting also in cell proliferation induction. Drives NF-kappa-B activation, probably through IRS1 and the activation of the AKT serine/threonine kinase. Recruitment of IRS1 to activated ALK and the activation of NF-kappa-B are essential for the autocrine growth and survival signaling of MDK.

Tocris Summary for ALK Gene

  • Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase (RTK) that was first identified in anaplastic large cell lymphoma (ALCL) as part of the fusion protein NPM-ALK. ALK has been implicated in the pathogenesis of many types of cancer.

Gene Wiki entry for ALK Gene

PharmGKB "VIP" Summary for ALK Gene

No data available for fRNAdb sequence ontologies and piRNA Summary for ALK Gene

Genomics for ALK Gene

Regulatory Elements for ALK Gene

Genomic Location for ALK Gene

Chromosome:
2
Start:
29,192,774 bp from pter
End:
29,921,611 bp from pter
Size:
728,838 bases
Orientation:
Minus strand

Genomic View for ALK Gene

Genes around ALK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ALK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ALK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ALK Gene

Proteins for ALK Gene

  • Protein details for ALK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UM73-ALK_HUMAN
    Recommended name:
    ALK tyrosine kinase receptor
    Protein Accession:
    Q9UM73
    Secondary Accessions:
    • Q4ZFX9
    • Q53QQ6
    • Q53RZ4
    • Q59FI3
    • Q9Y4K6

    Protein attributes for ALK Gene

    Size:
    1620 amino acids
    Molecular mass:
    176442 Da
    Quaternary structure:
    • Homodimer. Homodimerizes when bound to ligand. Interacts with FRS2, IRS1, MDK, PTN and SHC1. Interacts with CBL, PIK3R1 and PLCG1 (By similarity).
    SequenceCaution:
    • Sequence=BAD92714.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ALK Gene

neXtProt entry for ALK Gene

Proteomics data for ALK Gene at MOPED

Selected DME Specific Peptides for ALK Gene

Post-translational modifications for ALK Gene

  • N-glycosylated.
  • Phosphorylated at tyrosine residues by autocatalysis, which activates kinase activity. In cells not stimulated by a ligand, receptor protein tyrosine phosphatase beta and zeta complex (PTPRB/PTPRZ1) dephosphorylates ALK at the sites in ALK that are undergoing autophosphorylation through autoactivation. Phosphorylation at Tyr-1507 is critical for SHC1 association.
  • Glycosylation at Asn 169, Asn 244, Asn 285, Asn 324, Asn 411, Asn 424, Asn 445, Asn 563, Asn 571, Asn 627, Asn 709, Asn 808, Asn 863, Asn 864, Asn 886, and Asn 986
  • Modification sites at PhosphoSitePlus

Other Protein References for ALK Gene

Domains & Families for ALK Gene

Graphical View of Domain Structure for InterPro Entry

Q9UM73

UniProtKB/Swiss-Prot:

ALK_HUMAN :
  • Contains 1 LDL-receptor class A domain.
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
Domain:
  • Contains 1 LDL-receptor class A domain.
  • Contains 2 MAM domains.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
genes like me logo Genes that share domains with ALK: view

Function for ALK Gene

Molecular function for ALK Gene

GENATLAS Biochemistry:
anaplastic (CD30 + large cell) lymphoma kinase playing an important role in brain development,involved in anaplastic nodal non Hodgkin lymphoma or Hodgkin disease with translocation t(2;5)(p23;q35) or inv2(23;q35),see NPM1
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by ligand-binding and subsequent phosphorylation. Inactivated through dephosphorylation by receptor protein tyrosine phosphatase beta and zeta complex (PTPRB/PTPRZ1) when there is no stimulation by a ligand. Staurosporine, crizotinib and CH5424802 act as inhibitors of ALK kinase activity.
UniProtKB/Swiss-Prot Function:
Neuronal orphan receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system. Transduces signals from ligands at the cell surface, through specific activation of the mitogen-activated protein kinase (MAPK) pathway. Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif. Following activation by ligand, ALK induces tyrosine phosphorylation of CBL, FRS2, IRS1 and SHC1, as well as of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Acts as a receptor for ligands pleiotrophin (PTN), a secreted growth factor, and midkine (MDK), a PTN-related factor, thus participating in PTN and MDK signal transduction. PTN-binding induces MAPK pathway activation, which is important for the anti-apoptotic signaling of PTN and regulation of cell proliferation. MDK-binding induces phosphorylation of the ALK target insulin receptor substrate (IRS1), activates mitogen-activated protein kinases (MAPKs) and PI3-kinase, resulting also in cell proliferation induction. Drives NF-kappa-B activation, probably through IRS1 and the activation of the AKT serine/threonine kinase. Recruitment of IRS1 to activated ALK and the activation of NF-kappa-B are essential for the autocrine growth and survival signaling of MDK.

Enzyme Numbers (IUBMB) for ALK Gene

Gene Ontology (GO) - Molecular Function for ALK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004713 protein tyrosine kinase activity IEA,IDA 9174053
genes like me logo Genes that share ontologies with ALK: view
genes like me logo Genes that share phenotypes with ALK: view

Human Phenotype Ontology for ALK Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for ALK Gene

MGI Knock Outs for ALK:

Animal Model Products

miRNA for ALK Gene

miRTarBase miRNAs that target ALK

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for ALK Gene

Localization for ALK Gene

Subcellular locations from UniProtKB/Swiss-Prot for ALK Gene

Cell membrane; Single-pass type I membrane protein. Note=Membrane attachment was crucial for promotion of neuron-like differentiation and cell proliferation arrest through specific activation of the MAP kinase pathway.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ALK Gene COMPARTMENTS Subcellular localization image for ALK gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytoskeleton 2
nucleus 2
cytosol 1
endoplasmic reticulum 1
lysosome 1
mitochondrion 1
vacuole 1

Gene Ontology (GO) - Cellular Components for ALK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ALK: view

Pathways & Interactions for ALK Gene

genes like me logo Genes that share pathways with ALK: view

Pathways by source for ALK Gene

SIGNOR curated interactions for ALK Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for ALK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity TAS 19459784
GO:0007165 signal transduction IEA,TAS 19459784
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA --
GO:0038061 NIK/NF-kappaB signaling TAS 19459784
GO:0046777 protein autophosphorylation TAS 19459784
genes like me logo Genes that share ontologies with ALK: view

Drugs & Compounds for ALK Gene

(53) Drugs for ALK Gene - From: DGIdb, HMDB, ClinicalTrials, ApexBio, Novoseek, PharmGKB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Crizotinib Approved Pharma Inhibition, Biomarker, inhibitor C-MET/ALK inhibitor,potent and ATP-competitve, cMET Inhibitors, Kinase Inhibitors, Anaplastic lymphoma kinase (ALK) inhibitor, Potent c-MET/ALK inhibitor 92
Ceritinib Approved Pharma 36
ado-trastuzumab emtansine Approved Pharma 62
Bevacizumab Approved, Investigational Pharma VEGF antagonist, Therapeutic Antibodies, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 1875
Carboplatin Approved Pharma Antitumor agent that forms platinum-DNA adducts., Platinum 1885

(13) Additional Compounds for ALK Gene - From: HMDB, Tocris, and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
GSK 1838705
1116235-97-2
KRCA 0008
1472795-20-2
PF 06463922
1454846-35-5
genes like me logo Genes that share compounds with ALK: view

Drug Products

Transcripts for ALK Gene

mRNA/cDNA for ALK Gene

(1) REFSEQ mRNAs :
(13) Additional mRNA sequences :
(12) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ALK Gene

Anaplastic lymphoma receptor tyrosine kinase:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ALK Gene

No ASD Table

Relevant External Links for ALK Gene

GeneLoc Exon Structure for
ALK
ECgene alternative splicing isoforms for
ALK

Expression for ALK Gene

mRNA expression in normal human tissues for ALK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ALK Gene

This gene is overexpressed in Pituitary (x6.4) and Brain - Hypothalamus (x5.3).

Protein differential expression in normal tissues from HIPED for ALK Gene

This gene is overexpressed in Fetal Brain (67.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ALK Gene



SOURCE GeneReport for Unigene cluster for ALK Gene Hs.654469

mRNA Expression by UniProt/SwissProt for ALK Gene

Q9UM73-ALK_HUMAN
Tissue specificity: Expressed in brain and CNS. Also expressed in the small intestine and testis, but not in normal lymphoid cells.
genes like me logo Genes that share expression patterns with ALK: view

Protein tissue co-expression partners for ALK Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for ALK Gene

This gene was present in the common ancestor of animals.

Orthologs for ALK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ALK 36
  • 97 (a)
OneToOne
ALK 35
  • 97.77 (n)
  • 96.99 (a)
cow
(Bos Taurus)
Mammalia ALK 36
  • 90 (a)
OneToOne
LOC536642 35
  • 87.89 (n)
  • 90.61 (a)
dog
(Canis familiaris)
Mammalia ALK 35
  • 89.8 (n)
  • 92.51 (a)
ALK 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Alk 16
Alk 35
  • 84.79 (n)
  • 88.38 (a)
Alk 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ALK 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ALK 36
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Alk 35
  • 85.27 (n)
  • 88.88 (a)
chicken
(Gallus gallus)
Aves ALK 35
  • 72.08 (n)
  • 74.25 (a)
ALK 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ALK 36
  • 72 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.30258 35
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495071 35
  • 64.46 (n)
  • 62.08 (a)
zebrafish
(Danio rerio)
Actinopterygii alk 35
  • 61.65 (n)
  • 60.57 (a)
alk 36
  • 51 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Alk 36
  • 25 (a)
OneToMany
Alk 37
  • 33 (a)
worm
(Caenorhabditis elegans)
Secernentea F09A5.2 37
  • 34 (a)
scd-2 37
  • 41 (a)
T25B9.5 37
  • 28 (a)
scd-2 36
  • 20 (a)
OneToMany
Species with no ortholog for ALK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ALK Gene

ENSEMBL:
Gene Tree for ALK (if available)
TreeFam:
Gene Tree for ALK (if available)

Paralogs for ALK Gene

Paralogs for ALK Gene

genes like me logo Genes that share paralogs with ALK: view

Variants for ALK Gene

Sequence variations from dbSNP and Humsavar for ALK Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1670283 - 29,193,706(+) AGAGA(C/T)CTCTG reference, missense
rs1881420 - 29,193,615(-) GCACA(A/G)GGTCC reference, missense
rs1881421 - 29,193,500(-) CACGA(C/G)AGGGG reference, missense
rs34617074 - 29,920,391(+) CTAGC(A/G)AGCCG reference, missense
rs55697431 - 29,920,173(+) CCCCA(A/C)AGCCG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ALK Gene

Variant ID Type Subtype PubMed ID
dgv1163e1 CNV Complex 17122850
esv34904 CNV Gain 17911159
nsv438237 CNV Loss 16468122
nsv455997 CNV Loss 19166990
esv2719856 CNV Deletion 23290073
nsv524336 CNV Loss 19592680
esv2678336 CNV Deletion 23128226
nsv525718 CNV Loss 19592680
nsv456008 CNV Loss 19166990
dgv4073n71 CNV Loss 21882294
nsv438248 CNV Loss 16468122
nsv9480 CNV Loss 18304495
esv2663423 CNV Deletion 23128226
esv23879 CNV Loss 19812545
nsv817706 CNV Loss 17921354
esv2421745 CNV Deletion 20811451
nsv515557 CNV Loss 19592680
nsv441750 CNV CNV 18776908
nsv514056 CNV Loss 21397061
esv271348 CNV Insertion 20981092
esv2671680 CNV Deletion 23128226
esv271041 CNV Insertion 20981092
esv274310 CNV Insertion 20981092
esv2675184 CNV Deletion 23128226
nsv2659 CNV Insertion 18451855
nsv433197 CNV Loss 18776910
esv990532 CNV Insertion 20482838
esv1191389 CNV Insertion 17803354
nsv833636 CNV Gain 17160897
nsv2660 CNV Insertion 18451855
esv2667588 CNV Deletion 23128226
esv29115 CNV Loss 19812545
esv8173 CNV Gain 19470904
esv2719857 CNV Deletion 23290073
esv4149 CNV Deletion 18987735
esv2719858 CNV Deletion 23290073
nsv471776 CNV Loss 16327809
esv1273908 CNV Deletion 17803354
nsv2661 CNV Loss 18451855
esv270240 CNV Insertion 20981092

Variation tolerance for ALK Gene

Residual Variation Intolerance Score: 2.93% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.41; 92.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ALK Gene

HapMap Linkage Disequilibrium report
ALK
Human Gene Mutation Database (HGMD)
ALK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ALK Gene

Disorders for ALK Gene

MalaCards: The human disease database

(62) MalaCards diseases for ALK Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
neuroblastoma 3
  • neuroblastoma, susceptibility to, 3
inflammatory myofibroblastic tumor
  • inflammatory fibrosarcoma
alk-positive anaplastic large cell lymphoma
  • alk+ alcl
alk-positive large b-cell lymphoma
  • alk+ lbcl
neuroblastoma
  • neuroblastoma 1
- elite association - COSMIC cancer census association via MalaCards
Search ALK in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

ALK_HUMAN
  • Note=A chromosomal aberration involving ALK is found in a form of non-Hodgkin lymphoma. Translocation t(2;5)(p23;q35) with NPM1. The resulting chimeric NPM1-ALK protein homodimerize and the kinase becomes constitutively activated. The constitutively active fusion proteins are responsible for 5-10% of non-Hodgkin lymphomas.
  • Note=A chromosomal aberration involving ALK is associated with inflammatory myofibroblastic tumors (IMTs). Translocation t(2;11)(p23;p15) with CARS; translocation t(2;4)(p23;q21) with SEC31A.
  • Note=A chromosomal aberration involving ALK is associated with anaplastic large-cell lymphoma (ALCL). Translocation t(2;17)(p23;q25) with ALO17.
  • Neuroblastoma 3 (NBLST3) [MIM:613014]: A common neoplasm of early childhood arising from embryonic cells that form the primitive neural crest and give rise to the adrenal medulla and the sympathetic nervous system. {ECO:0000269 PubMed:18724359, ECO:0000269 PubMed:18923523, ECO:0000269 PubMed:18923525}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
  • Note=The ALK signaling pathway plays an important role in glioblastoma, the most common malignant brain tumor of adults and one of the most lethal cancers. It regulates both glioblastoma migration and growth.

Genatlas disease for ALK Gene

nodal and extranodal,CD30+,anaplastic large-cell non Hodgkins lymphoma,Hodgkin disease with translocation t(2;5)(p23;q35),infalmmatory myofibroblastic tumors

Relevant External Links for ALK

Genetic Association Database (GAD)
ALK
Human Genome Epidemiology (HuGE) Navigator
ALK
Tumor Gene Database (TGDB):
ALK
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ALK
genes like me logo Genes that share disorders with ALK: view

Publications for ALK Gene

  1. Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma. (PMID: 8122112) Morris S.W. … Look A.T. (Science 1994) 2 3 4 23 67
  2. Expression of ALK protein, mRNA and fusion transcripts in anaplastic large cell lymphoma. (PMID: 19135051) Huang W. … Zhou X. (Exp. Mol. Pathol. 2009) 3 23
  3. ALK expression in rhabdomyosarcomas: correlation with histologic subtype and fusion status. (PMID: 18788887) Corao D.A. … Pawel B.R. (Pediatr. Dev. Pathol. 2009) 3 23
  4. The enzymatic activity of 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase is enhanced by NPM-ALK: new insights in ALK-mediated pathogenesis and the treatment of ALCL. (PMID: 18845790) Boccalatte F.E. … Inghirami G. (Blood 2009) 3 23
  5. EML4-ALK rearrangement in non-small cell lung cancer and non-tumor lung tissues. (PMID: 19147828) Martelli M.P. … Falini B. (Am. J. Pathol. 2009) 3 23

Products for ALK Gene

Sources for ALK Gene

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