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Aliases for ALG5 Gene

Aliases for ALG5 Gene

  • ALG5, Dolichyl-Phosphate Beta-Glucosyltransferase 2 3
  • Asparagine-Linked Glycosylation 5 Homolog (Yeast, Dolichyl-Phosphate Beta-Glucosyltransferase) 2 3
  • Asparagine-Linked Glycosylation Protein 5 Homolog 3 4
  • DolP-Glucosyltransferase 3 4
  • EC 2.4.1.117 4 63
  • Asparagine-Linked Glycosylation 5, Dolichyl-Phosphate Beta-Glucosyltransferase Homolog (S. Cerevisiae) 2
  • Asparagine-Linked Glycosylation 5 Homolog (S. Cerevisiae, Dolichyl-Phosphate Beta-Glucosyltransferase) 3
  • Asparagine-Linked Glycosylation 5, Dolichyl-Phosphate Beta-Glucosyltransferase Homolog 3
  • Dolichyl-Phosphate Beta-Glucosyltransferase 3
  • Dolichyl Phosphate Glucosyltransferase 3
  • Alg5, S. Cerevisiae, Homolog Of 3
  • BA421P11.2 3
  • EC 2.4.1 63

External Ids for ALG5 Gene

Previous GeneCards Identifiers for ALG5 Gene

  • GC13M035510
  • GC13M031510
  • GC13M036460
  • GC13M035321
  • GC13M036421
  • GC13M037523
  • GC13M018335

Summaries for ALG5 Gene

Entrez Gene Summary for ALG5 Gene

  • This gene encodes a member of the glycosyltransferase 2 family. The encoded protein participates in glucosylation of the oligomannose core in N-linked glycosylation of proteins. The addition of glucose residues to the oligomannose core is necessary to ensure substrate recognition, and therefore, effectual transfer of the oligomannose core to the nascent glycoproteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]

GeneCards Summary for ALG5 Gene

ALG5 (ALG5, Dolichyl-Phosphate Beta-Glucosyltransferase) is a Protein Coding gene. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include oligosaccharyl transferase activity and dolichyl-phosphate beta-glucosyltransferase activity.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ALG5 Gene

Genomics for ALG5 Gene

Regulatory Elements for ALG5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ALG5 Gene

Start:
36,949,770 bp from pter
End:
37,000,261 bp from pter
Size:
50,492 bases
Orientation:
Minus strand

Genomic View for ALG5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ALG5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ALG5 Gene

Proteins for ALG5 Gene

  • Protein details for ALG5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y673-ALG5_HUMAN
    Recommended name:
    Dolichyl-phosphate beta-glucosyltransferase
    Protein Accession:
    Q9Y673
    Secondary Accessions:
    • B4DR37
    • Q5TBA6

    Protein attributes for ALG5 Gene

    Size:
    324 amino acids
    Molecular mass:
    36946 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ALG5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ALG5 Gene

Proteomics data for ALG5 Gene at MOPED

Selected DME Specific Peptides for ALG5 Gene

Post-translational modifications for ALG5 Gene

  • Glycosylation at Asn281
  • Modification sites at PhosphoSitePlus

Other Protein References for ALG5 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for ALG5 Gene

Gene Families for ALG5 Gene

HGNC:
  • GLT2 :Glycosyltransferase family 2 domain containing

Protein Domains for ALG5 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y673

UniProtKB/Swiss-Prot:

ALG5_HUMAN :
  • Q9Y673
Family:
  • Belongs to the glycosyltransferase 2 family.
genes like me logo Genes that share domains with ALG5: view

Function for ALG5 Gene

Molecular function for ALG5 Gene

UniProtKB/Swiss-Prot CatalyticActivity: UDP-glucose + dolichyl phosphate = UDP + dolichyl beta-D-glucosyl phosphate

Enzyme Numbers (IUBMB) for ALG5 Gene

Gene Ontology (GO) - Molecular Function for ALG5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004576 oligosaccharyl transferase activity TAS 10359825
GO:0004581 dolichyl-phosphate beta-glucosyltransferase activity IEA --
genes like me logo Genes that share ontologies with ALG5: view

Phenotypes for ALG5 Gene

genes like me logo Genes that share phenotypes with ALG5: view

Animal Model Products

CRISPR Products

miRNA for ALG5 Gene

miRTarBase miRNAs that target ALG5

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ALG5

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for ALG5 Gene

Localization for ALG5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ALG5 Gene

Endoplasmic reticulum membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ALG5 Gene COMPARTMENTS Subcellular localization image for ALG5 gene
Compartment Confidence
endoplasmic reticulum 5
cytosol 1

Gene Ontology (GO) - Cellular Components for ALG5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ALG5: view

Pathways for ALG5 Gene

genes like me logo Genes that share pathways with ALG5: view

UniProtKB/Swiss-Prot Q9Y673-ALG5_HUMAN

  • Pathway: Protein modification; protein glycosylation

Gene Ontology (GO) - Biological Process for ALG5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006486 protein glycosylation TAS 10359825
GO:0006488 dolichol-linked oligosaccharide biosynthetic process TAS --
GO:0007368 determination of left/right symmetry IEA --
GO:0018279 protein N-linked glycosylation via asparagine TAS --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with ALG5: view

Compounds for ALG5 Gene

(4) HMDB Compounds for ALG5 Gene

Compound Synonyms Cas Number PubMed IDs
Dolichol phosphate
  • dolichol-phosphate
34457-14-2
Dolichyl b-D-glucosyl phosphate
  • Dolichol monophosphate glucose
220496-27-5
Uridine 5'-diphosphate
  • 5'-UDP
58-98-0
Uridine diphosphate glucose
  • (UPD)-glucose
133-89-1
genes like me logo Genes that share compounds with ALG5: view

Transcripts for ALG5 Gene

Unigene Clusters for ALG5 Gene

ALG5, dolichyl-phosphate beta-glucosyltransferase:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ALG5

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ALG5 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b
SP1: -
SP2: - -
SP3:

Relevant External Links for ALG5 Gene

GeneLoc Exon Structure for
ALG5
ECgene alternative splicing isoforms for
ALG5

Expression for ALG5 Gene

mRNA expression in normal human tissues for ALG5 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ALG5 Gene

SOURCE GeneReport for Unigene cluster for ALG5 Gene Hs.507769

mRNA Expression by UniProt/SwissProt for ALG5 Gene

Q9Y673-ALG5_HUMAN
Tissue specificity: Expressed in pancreas, placenta, liver, heart, brain, kidney, skeletal muscle, and lung
genes like me logo Genes that share expressions with ALG5: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ALG5 Gene

Orthologs for ALG5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ALG5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ALG5 35
  • 99.38 (n)
  • 99.38 (a)
ALG5 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ALG5 35
  • 91.17 (n)
  • 93.38 (a)
ALG5 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ALG5 35
  • 91.77 (n)
  • 94.44 (a)
ALG5 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Alg5 35
  • 86.98 (n)
  • 90.4 (a)
Alg5 16
Alg5 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ALG5 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ALG5 36
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Alg5 35
  • 86.75 (n)
  • 91.72 (a)
chicken
(Gallus gallus)
Aves ALG5 35
  • 78.52 (n)
  • 82.39 (a)
ALG5 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ALG5 36
  • 78 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia alg5-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia alg5 35
  • 71.78 (n)
  • 75.67 (a)
Str.709 35
zebrafish
(Danio rerio)
Actinopterygii alg5 35
  • 68.11 (n)
  • 73.67 (a)
alg5 36
  • 71 (a)
OneToOne
wufk42e01 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008315 35
  • 55.74 (n)
  • 59.12 (a)
fruit fly
(Drosophila melanogaster)
Insecta wol 35
  • 58.22 (n)
  • 61.11 (a)
wol 36
  • 55 (a)
OneToOne
CG7870 37
  • 60 (a)
worm
(Caenorhabditis elegans)
Secernentea H43I07.3 35
  • 53.71 (n)
  • 48.06 (a)
H43I07.3 36
  • 42 (a)
OneToOne
H43I07.3 37
  • 43 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL133C 35
  • 49.67 (n)
  • 44.71 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ALG5 35
  • 51.78 (n)
  • 45.39 (a)
ALG5 36
  • 38 (a)
OneToOne
ALG5 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C16071g 35
  • 53.75 (n)
  • 47.04 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G39630 35
  • 57.41 (n)
  • 50.95 (a)
rice
(Oryza sativa)
Liliopsida Os.4641 35
Os03g0821800 35
  • 55.47 (n)
  • 52.08 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU06386 35
  • 48.13 (n)
  • 40.4 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes alg5 35
  • 50.28 (n)
  • 39.93 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.587 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 54 (a)
OneToOne
Species with no ortholog for ALG5:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ALG5 Gene

ENSEMBL:
Gene Tree for ALG5 (if available)
TreeFam:
Gene Tree for ALG5 (if available)

Paralogs for ALG5 Gene

No data available for Paralogs for ALG5 Gene

Variants for ALG5 Gene

Sequence variations from dbSNP and Humsavar for ALG5 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs1924419 -- 36,956,686(+) tggga(A/G)ctctg intron-variant
rs1924420 -- 36,956,703(+) ctcta(A/T)tacat intron-variant
rs1924421 -- 36,959,219(+) gatgg(G/T)gagat intron-variant
rs1924422 -- 36,966,077(+) CACAT(A/G)TATTT intron-variant
rs1937761 -- 36,983,760(-) TTAAG(A/C)TTCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ALG5 Gene

Variant ID Type Subtype PubMed ID
nsv522336 CNV Gain 19592680
esv2454960 CNV Deletion 19546169
esv267708 CNV Insertion 20981092
esv272243 CNV Insertion 20981092

Relevant External Links for ALG5 Gene

HapMap Linkage Disequilibrium report
ALG5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ALG5 Gene

Disorders for ALG5 Gene

(1) University of Copenhagen DISEASES for ALG5 Gene

genes like me logo Genes that share disorders with ALG5: view

No data available for UniProtKB/Swiss-Prot for ALG5 Gene

Publications for ALG5 Gene

  1. A mutation in the human ortholog of the Saccharomyces cerevisiae ALG6 gene causes carbohydrate-deficient glycoprotein syndrome type-Ic. (PMID: 10359825) Imbach T. … Hennet T. (Proc. Natl. Acad. Sci. U.S.A. 1999) 2 3 4 23
  2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Defining the membrane proteome of NK cells. (PMID: 19946888) Ghosh D. … Wilkins J.A. (J Mass Spectrom 2010) 3
  5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3

Products for ALG5 Gene

Sources for ALG5 Gene

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