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ALG5 Gene

protein-coding   GIFtS: 57
GCID: GC13M037523

ALG5, Dolichyl-Phosphate Beta-Glucosyltransferase

(Previous names: asparagine-linked glycosylation 5 homolog (yeast, dolichyl-phosphate...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ALG5, Dolichyl-Phosphate Beta-Glucosyltransferase1 2     Asparagine-Linked Glycosylation 5, Dolichyl-Phosphate
Beta-Glucosyltransferase Homolog2
Asparagine-Linked Glycosylation 5 Homolog (Yeast, Dolichyl-Phosphate
Beta-Glucosyltransferase)1 2
     bA421P11.22
Asparagine-Linked Glycosylation Protein 5 Homolog2 3     dolP-glucosyltransferase2
EC 2.4.1.1173 8     Dolichyl Phosphate Glucosyltransferase2
Asparagine-Linked Glycosylation 5, Dolichyl-Phosphate
Beta-Glucosyltransferase Homolog (S. Cerevisiae)1
     Dolichyl-Phosphate Beta-Glucosyltransferase2
Alg5, S. Cerevisiae, Homolog Of2     DolP-glucosyltransferase3
Asparagine-Linked Glycosylation 5 Homolog (S. Cerevisiae,
Dolichyl-Phosphate Beta-Glucosyltransferase)2
     EC 2.4.18

External Ids:    HGNC: 202661   Entrez Gene: 298802   Ensembl: ENSG000001206977   OMIM: 6045655   UniProtKB: Q9Y6733   

Export aliases for ALG5 gene to outside databases

Previous GC identifers: GC13M035510 GC13M031510 GC13M036460 GC13M035321 GC13M036421 GC13M018335


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ALG5 Gene:
This gene encodes a member of the glycosyltransferase 2 family. The encoded protein participates in glucosylation
of the oligomannose core in N-linked glycosylation of proteins. The addition of glucose residues to the
oligomannose core is necessary to ensure substrate recognition, and therefore, effectual transfer of the
oligomannose core to the nascent glycoproteins. Multiple transcript variants encoding different isoforms have
been found for this gene. (provided by RefSeq, Nov 2008)

GeneCards Summary for ALG5 Gene:
ALG5 (ALG5, dolichyl-phosphate beta-glucosyltransferase) is a protein-coding gene. Diseases associated with ALG5 include congenital disorder of glycosylation, and malaria. GO annotations related to this gene include oligosaccharyl transferase activity and dolichyl-phosphate beta-glucosyltransferase activity.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000013.11  NT_024524.15  NC_018924.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ALG5 gene promoter:
         GR   GR-beta   Lmo2   Tal-1beta   MEF-2A   GR-alpha   aMEF-2   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidALG5 promoter sequence
   Search Chromatin IP Primers for ALG5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ALG5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q13.3   Ensembl cytogenetic band:  13q13.3   HGNC cytogenetic band: 13q13.1

ALG5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ALG5 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M037523:  view genomic region     (about GC identifiers)

Start:
37,523,907 bp from pter      End:
37,574,398 bp from pter
Size:
50,492 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ALG5_HUMAN, Q9Y673 (See protein sequence)
Recommended Name: Dolichyl-phosphate beta-glucosyltransferase  
Size: 324 amino acids; 36946 Da
Secondary accessions: B4DR37 Q5TBA6
Alternative splicing: 2 isoforms:  Q9Y673-1   Q9Y673-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ALG5: NX_Q9Y673

Explore proteomics data for ALG5 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn281
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for ALG5 (Q9Y673)
     VPSYNEE  DTQCGFKL 


    See ALG5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001135836.1  NP_037470.1  

    ENSEMBL proteins: 
     ENSP00000239891   ENSP00000390533   ENSP00000389647  
    Reactome Protein details: Q9Y673

    ALG5 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    GLT2: Glycosyltransferase family 2 domain containing

    1 InterPro protein domain:
     IPR001173 Glyco_trans_2

    Graphical View of Domain Structure for InterPro Entry Q9Y673

    ProtoNet protein and cluster: Q9Y673

    1 Blocks protein domain: IPB001173 Glycosyl transferase

    UniProtKB/Swiss-Prot: ALG5_HUMAN, Q9Y673
    Similarity: Belongs to the glycosyltransferase 2 family


    ALG5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ALG5_HUMAN, Q9Y673
    Catalytic activity: UDP-glucose + dolichyl phosphate = UDP + dolichyl beta-D-glucosyl phosphate

         Enzyme Numbers (IUBMB): EC 2.4.1.1171 2 EC 2.4.12

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004576oligosaccharyl transferase activity TAS10359825
    GO:0004581dolichyl-phosphate beta-glucosyltransferase activity IEA--
    GO:0016757transferase activity, transferring glycosyl groups ----
         
    ALG5 for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Alg5):
     embryogenesis  mortality/aging 

    ALG5 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ALG5
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    miRNA
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    miRTarBase miRNAs that target ALG5:
    hsa-mir-24-3p (MIRT030480)

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    Search for qRT-PCR Assays for microRNAs that regulate ALG5
    SwitchGear 3'UTR luciferase reporter plasmidALG5 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ALG5_HUMAN, Q9Y673: Endoplasmic reticulum membrane; Single-pass type II membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    cytosol1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0016021integral component of membrane IEA--

    ALG5 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ALG5 About    
    See pathways by source

    SuperPathContained pathways About
    1Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Asparagine N-linked glycosylation0.49
    Metabolism of proteins0.30
    N-Glycan biosynthesis0.49
    dolichyl-diphosphooligosaccharide biosynthesis0.00
    Post-translational protein modification0.43
    Synthesis of substrates in N-glycan biosythesis0.00
    Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein0.38
    Synthesis of dolichyl-phosphate-glucose0.00
    2Metabolism
    Metabolic pathways0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for ALG5
        dolichyl-diphosphooligosaccharide biosynthesis


    1 Reactome Pathway for ALG5
        Synthesis of dolichyl-phosphate-glucose


    2 Kegg Pathways  (Kegg details for ALG5):
        N-Glycan biosynthesis
    Metabolic pathways

    UniProtKB/Swiss-Prot: ALG5_HUMAN, Q9Y673
    Pathway: Protein modification; protein glycosylation


    ALG5 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ALG5
    Interactions:

        Search GeneGlobe Interaction Network for ALG5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ALG5 (Q9Y6733 ENSP000002398914) via UniProtKB, MINT, STRING, and/or I2D (see all 108)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    DDOSTP396563, ENSP000003641884I2D: score=3 STRING: ENSP00000364188
    PIGKQ926433, ENSP000003598484I2D: score=2 STRING: ENSP00000359848
    RPN1P048433, ENSP000002962554I2D: score=2 STRING: ENSP00000296255
    ALG12Q9BV103, ENSP000003338134I2D: score=1 STRING: ENSP00000333813
    ALG3Q926853, ENSP000003807934I2D: score=1 STRING: ENSP00000380793
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006486protein glycosylation TAS10359825
    GO:0006488dolichol-linked oligosaccharide biosynthetic process TAS--
    GO:0007368determination of left/right symmetry IEA--
    GO:0018279protein N-linked glycosylation via asparagine TAS--
    GO:0043687post-translational protein modification TAS--

    ALG5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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      Browse compounds at ApexBio 

    Browse Tocris compounds for ALG5

    4 HMDB Compounds for ALG5    About this table
    CompoundSynonyms CAS #PubMed Ids
    Dolichol phosphatedolichol-phosphate (see all 6)34457-14-2--
    Dolichyl b-D-glucosyl phosphateDolichol monophosphate glucose (see all 10)220496-27-5--
    Uridine 5'-diphosphate5'-UDP (see all 9)58-98-0--
    Uridine diphosphate glucose(UPD)-glucose (see all 24)133-89-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ALG5 gene (2 alternative transcripts): 
    NM_001142364.1  NM_013338.4  

    Unigene Cluster for ALG5:

    ALG5, dolichyl-phosphate beta-glucosyltransferase
    Hs.507769  [show with all ESTs]
    Unigene Representative Sequence: AK097252
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000239891(uc001uvy.3 uc010ter.2) ENST00000486410 ENST00000460230
    ENST00000496689 ENST00000443765(uc010teq.2) ENST00000413537
    miRNA
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    Additional mRNA sequence: 

    AF088028.1 AF161498.1 AF183413.1 AK097252.1 AK299085.1 BC012531.1 HM245395.1 

    14 DOTS entries:

    DT.215118  DT.100819579  DT.100819581  DT.95172124  DT.95204467  DT.101966659  DT.95123802  DT.100819578 
    DT.102836936  DT.97858894  DT.95204472  DT.95204487  DT.120794453  DT.435228 

    Selected AceView cDNA sequences (see all 146):

    BE502329 AA534499 AI093199 W70281 CA436929 BQ957664 AV725253 BM767175 
    AF161498 W52165 BG163404 BM548894 AI769938 AI027225 BG000502 CB989866 
    CA428354 AL525209 BU683287 AF088028 BM823264 AA347666 CR625593 NM_013338 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for ALG5    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b
    SP1:                                                  -                           
    SP2:        -           -                                                         
    SP3:                                                                              


    ECgene alternative splicing isoforms for ALG5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ALG5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATGGGTTCC
    ALG5 Expression
    About this image

    ALG5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ALG5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.507769

    UniProtKB/Swiss-Prot: ALG5_HUMAN, Q9Y673
    Tissue specificity: Expressed in pancreas, placenta, liver, heart, brain, kidney, skeletal muscle, and lung

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALG5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ALG5 gene from Selected species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Alg51 , 5 asparagine-linked glycosylation 5 homolog (yeast, dolichyl-phosphate more5
    asparagine-linked glycosylation 5 (dolichyl-phosphate more1
    86.98(n)1
    90.4(a)1
      3 (25.60 cM)5
    662481  NM_025442.31  NP_079718.11 
     547355395 
    chicken
    (Gallus gallus)
    Aves ALG51 asparagine-linked glycosylation 5, dolichyl-phosphate more 78.52(n)
    82.39(a)
      418898  XM_417093.4  XP_417093.2 
    lizard
    (Anolis carolinensis)
    Reptilia ALG56
    ALG5, dolichyl-phosphate beta-glucosyltransferase
    78(a)
    1 ↔ 1
    2(82552997-82574280)
    African clawed frog
    (Xenopus laevis)
    Amphibia alg5-prov2 Alg5, S. cerevisiae, homolog of 76.67(n)    BC044127.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufk42e012 Transcribed sequence with moderate similarity to protein more 75.97(n)    57084317 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG78703
    wol1
    dolichyl-phosphate
    beta-glucosyltransferase3
    wollknaeuel1
    60(a)3
    58.22(n)1
    61.11(a)1
      29A33
    341341  NM_135358.21  NP_609202.11 
    worm
    (Caenorhabditis elegans)
    Secernentea H43I07.31 , 3 H43I07.31 43(a)3
    53.71(n)1
    48.06(a)1
      V(4195430-4198906)3
    1788221  NM_171446.31  NP_741523.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ALG5(YPL227C)4
    ALG51
    UDP-glucose:dolichyl-phosphate glucosyltransferase, more4
    ALG51
    51.78(n)1
    45.39(a)1
      16(121167-120163)4
    8558741, 4  NP_015097.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT2G396301 AT2G39630 57.41(n)
    50.95(a)
      818546  NM_129519.4  NP_181493.1 
    rice
    (Oryza sativa)
    Liliopsida Os.46412 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 76.22(n)    NM_185170.1 


    ENSEMBL Gene Tree for ALG5 (if available)
    TreeFam Gene Tree for ALG5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ALG5 (see all 908)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1845285671,2
    --37523471(+) ACTCCC/TTCCAT 2 -- ds50010--------
    rs1890566561,2
    --37523502(+) GGCACA/GATCAT 2 -- ds50010--------
    rs1444532091,2
    C--37523668(+) AATAGA/GTTTCT 2 -- ds50010--------
    rs1394053311,2
    --37523797(+) TAGGGA/TAAGAA 2 -- ds50010--------
    rs1129361821,2
    F--37523805(+) GAATAG/ACTTCT 2 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs1180681421,2
    C,F--37523811(+) CTTCTG/TTCTAC 2 -- ds50011Minor allele frequency- T:0.02NA 120
    rs1873547871,2
    --37523872(+) AGAAAA/CTCTGA 2 -- ds50010--------
    rs1124513841,2
    F--37523942(+) CTTATG/TGAAAG 2 -- ut311Minor allele frequency- T:0.50CSA 4
    rs1451418071,2
    C--37524047(+) CTGAAC/GCATAA 2 -- ut310--------
    rs2006015991,2
    --37524052(+) GCATAA/GGAACA 2 -- ut310--------

    HapMap Linkage Disequilibrium report for ALG5 (37523907 - 37574398 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ALG5:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2454960CNV Deletion19546169
    esv272243CNV Insertion20981092
    esv267708CNV Insertion20981092
    nsv522336CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604565    OMIM disorders: --

    2 diseases for ALG5:    
    About MalaCards
    congenital disorder of glycosylation    malaria

    1 disease from the University of Copenhagen DISEASES database for ALG5:
    Congenital disorder of glycosylation

    ALG5 for disorders           About GeneDecksing


    Export disorders for ALG5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ALG5 gene, integrated from 10 sources (see all 12):
    (articles sorted by number of sources associating them with ALG5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A mutation in the human ortholog of the Saccharomyces cerevisiae ALG6 gene causes carbohydrate-deficient glycoprotein syndrome type-Ic. (PubMed id 10359825)1, 2, 3, 9 Imbach T....Hennet T. (Proc. Natl. Acad. Sci. U.S.A. 1999)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (Genome Res. 2000)
    4. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    5. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    6. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    7. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (Genome Res. 2004)
    8. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)2 Dunham A.... Ross M.T. (Nature 2004)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 29880 HGNC: 20266 AceView: ALG5 Ensembl:ENSG00000120697 euGenes: HUgn29880
    ECgene: ALG5 Kegg: 29880 H-InvDB: ALG5

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ALG5 Pharmacogenomics, SNPs, Pathways
    GGDBhttp://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=ALG5

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ALG5 gene:
    Search GeneIP for patents involving ALG5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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