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Aliases for ALG5 Gene

Aliases for ALG5 Gene

  • ALG5, Dolichyl-Phosphate Beta-Glucosyltransferase 2 3
  • Asparagine-Linked Glycosylation 5 Homolog (Yeast, Dolichyl-Phosphate Beta-Glucosyltransferase) 2 3
  • Asparagine-Linked Glycosylation Protein 5 Homolog 3 4
  • DolP-Glucosyltransferase 3 4
  • EC 2.4.1.117 4 63
  • Asparagine-Linked Glycosylation 5, Dolichyl-Phosphate Beta-Glucosyltransferase Homolog (S. Cerevisiae) 2
  • Asparagine-Linked Glycosylation 5 Homolog (S. Cerevisiae, Dolichyl-Phosphate Beta-Glucosyltransferase) 3
  • Asparagine-Linked Glycosylation 5, Dolichyl-Phosphate Beta-Glucosyltransferase Homolog 3
  • Dolichyl Phosphate Glucosyltransferase 3
  • Alg5, S. Cerevisiae, Homolog Of 3
  • BA421P11.2 3
  • EC 2.4.1 63

External Ids for ALG5 Gene

Previous GeneCards Identifiers for ALG5 Gene

  • GC13M035510
  • GC13M031510
  • GC13M036460
  • GC13M035321
  • GC13M036421
  • GC13M037523
  • GC13M018335

Summaries for ALG5 Gene

Entrez Gene Summary for ALG5 Gene

  • This gene encodes a member of the glycosyltransferase 2 family. The encoded protein participates in glucosylation of the oligomannose core in N-linked glycosylation of proteins. The addition of glucose residues to the oligomannose core is necessary to ensure substrate recognition, and therefore, effectual transfer of the oligomannose core to the nascent glycoproteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]

GeneCards Summary for ALG5 Gene

ALG5 (ALG5, Dolichyl-Phosphate Beta-Glucosyltransferase) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Metabolism. GO annotations related to this gene include oligosaccharyl transferase activity and dolichyl-phosphate beta-glucosyltransferase activity.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ALG5 Gene

Genomics for ALG5 Gene

Regulatory Elements for ALG5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ALG5 Gene

Chromosome:
13
Start:
36,949,770 bp from pter
End:
37,000,261 bp from pter
Size:
50,492 bases
Orientation:
Minus strand

Genomic View for ALG5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ALG5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ALG5 Gene

Proteins for ALG5 Gene

  • Protein details for ALG5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y673-ALG5_HUMAN
    Recommended name:
    Dolichyl-phosphate beta-glucosyltransferase
    Protein Accession:
    Q9Y673
    Secondary Accessions:
    • B4DR37
    • Q5TBA6

    Protein attributes for ALG5 Gene

    Size:
    324 amino acids
    Molecular mass:
    36946 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ALG5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ALG5 Gene

Proteomics data for ALG5 Gene at MOPED

Selected DME Specific Peptides for ALG5 Gene

Post-translational modifications for ALG5 Gene

  • Glycosylation at Asn 281
  • Modification sites at PhosphoSitePlus

Other Protein References for ALG5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for ALG5 Gene

Gene Families for ALG5 Gene

Protein Domains for ALG5 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y673

UniProtKB/Swiss-Prot:

ALG5_HUMAN :
  • Belongs to the glycosyltransferase 2 family.
Family:
  • Belongs to the glycosyltransferase 2 family.
genes like me logo Genes that share domains with ALG5: view

Function for ALG5 Gene

Molecular function for ALG5 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
UDP-glucose + dolichyl phosphate = UDP + dolichyl beta-D-glucosyl phosphate

Enzyme Numbers (IUBMB) for ALG5 Gene

Gene Ontology (GO) - Molecular Function for ALG5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity IBA --
GO:0004576 oligosaccharyl transferase activity TAS 10359825
GO:0004581 dolichyl-phosphate beta-glucosyltransferase activity IEA --
GO:0004582 dolichyl-phosphate beta-D-mannosyltransferase activity IBA --
genes like me logo Genes that share ontologies with ALG5: view
genes like me logo Genes that share phenotypes with ALG5: view

Animal Model Products

miRNA for ALG5 Gene

miRTarBase miRNAs that target ALG5

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ALG5

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for ALG5 Gene

Localization for ALG5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ALG5 Gene

Endoplasmic reticulum membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ALG5 Gene COMPARTMENTS Subcellular localization image for ALG5 gene
Compartment Confidence
endoplasmic reticulum 4
cytosol 3

Gene Ontology (GO) - Cellular Components for ALG5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ALG5: view

Pathways & Interactions for ALG5 Gene

genes like me logo Genes that share pathways with ALG5: view

UniProtKB/Swiss-Prot Q9Y673-ALG5_HUMAN

  • Pathway: Protein modification; protein glycosylation

Gene Ontology (GO) - Biological Process for ALG5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006486 protein glycosylation TAS 10359825
GO:0006487 protein N-linked glycosylation IBA --
GO:0006488 dolichol-linked oligosaccharide biosynthetic process TAS --
GO:0006506 GPI anchor biosynthetic process IBA --
GO:0007368 determination of left/right symmetry IEA --
genes like me logo Genes that share ontologies with ALG5: view

No data available for SIGNOR curated interactions for ALG5 Gene

Drugs & Compounds for ALG5 Gene

(2) Drugs for ALG5 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Uridine 5'-diphosphate Experimental Pharma 0
dolichol phosphate Pharma Competitive, Inhibitor 0

(3) Additional Compounds for ALG5 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Dolichol-20
  • Dolichol
  • Dolichol (C100)
  • Dolichol 20
  • Dolichol phosphate
  • Dolichyl phosphate
2067-66-5
Dolichyl b-D-glucosyl phosphate
  • Dolichol monophosphate glucose
  • Dolichyl b-D-glucosyl phosphate
  • Dolichyl b-delta-glucosyl phosphate
  • Dolichyl beta-D-glucosyl phosphate
  • Dolichyl beta-delta-glucosyl phosphate
220496-27-5
Uridine diphosphate glucose
  • (UDP)glucose
  • (UPD)-glucose
  • UDP Glucose
  • UDP-a-D-Glucose
  • UDP-alpha-D-Glucose
133-89-1
genes like me logo Genes that share compounds with ALG5: view

Transcripts for ALG5 Gene

Unigene Clusters for ALG5 Gene

ALG5, dolichyl-phosphate beta-glucosyltransferase:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ALG5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ALG5 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b
SP1: -
SP2: - -
SP3:

Relevant External Links for ALG5 Gene

GeneLoc Exon Structure for
ALG5
ECgene alternative splicing isoforms for
ALG5

Expression for ALG5 Gene

mRNA expression in normal human tissues for ALG5 Gene

Protein differential expression in normal tissues from HIPED for ALG5 Gene

This gene is overexpressed in Salivary gland (7.4) and Stomach (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ALG5 Gene



SOURCE GeneReport for Unigene cluster for ALG5 Gene Hs.507769

mRNA Expression by UniProt/SwissProt for ALG5 Gene

Q9Y673-ALG5_HUMAN
Tissue specificity: Expressed in pancreas, placenta, liver, heart, brain, kidney, skeletal muscle, and lung
genes like me logo Genes that share expression patterns with ALG5: view

Protein tissue co-expression partners for ALG5 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ALG5 Gene

Orthologs for ALG5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ALG5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ALG5 35
  • 91.17 (n)
  • 93.38 (a)
ALG5 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ALG5 35
  • 91.77 (n)
  • 94.44 (a)
ALG5 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Alg5 35
  • 86.98 (n)
  • 90.4 (a)
Alg5 16
Alg5 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ALG5 35
  • 99.38 (n)
  • 99.38 (a)
ALG5 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Alg5 35
  • 86.75 (n)
  • 91.72 (a)
oppossum
(Monodelphis domestica)
Mammalia ALG5 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ALG5 36
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves ALG5 35
  • 78.52 (n)
  • 82.39 (a)
ALG5 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ALG5 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia alg5 35
  • 71.78 (n)
  • 75.67 (a)
Str.709 35
African clawed frog
(Xenopus laevis)
Amphibia alg5-prov 35
zebrafish
(Danio rerio)
Actinopterygii alg5 35
  • 68.11 (n)
  • 73.67 (a)
wufk42e01 35
alg5 36
  • 71 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG7870 37
  • 60 (a)
wol 35
  • 58.22 (n)
  • 61.11 (a)
wol 36
  • 55 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008315 35
  • 55.74 (n)
  • 59.12 (a)
worm
(Caenorhabditis elegans)
Secernentea H43I07.3 37
  • 43 (a)
H43I07.3 35
  • 53.71 (n)
  • 48.06 (a)
H43I07.3 36
  • 42 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL133C 35
  • 49.67 (n)
  • 44.71 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C16071g 35
  • 53.75 (n)
  • 47.04 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ALG5 35
  • 51.78 (n)
  • 45.39 (a)
ALG5 36
  • 38 (a)
OneToOne
ALG5 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G39630 35
  • 57.41 (n)
  • 50.95 (a)
rice
(Oryza sativa)
Liliopsida Os.4641 35
Os03g0821800 35
  • 55.47 (n)
  • 52.08 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.587 35
bread mold
(Neurospora crassa)
Ascomycetes NCU06386 35
  • 48.13 (n)
  • 40.4 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes alg5 35
  • 50.28 (n)
  • 39.93 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 54 (a)
OneToOne
Species with no ortholog for ALG5:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ALG5 Gene

ENSEMBL:
Gene Tree for ALG5 (if available)
TreeFam:
Gene Tree for ALG5 (if available)

Paralogs for ALG5 Gene

No data available for Paralogs for ALG5 Gene

Variants for ALG5 Gene

Structural Variations from Database of Genomic Variants (DGV) for ALG5 Gene

Variant ID Type Subtype PubMed ID
nsv522336 CNV Gain 19592680
esv2454960 CNV Deletion 19546169
esv267708 CNV Insertion 20981092
esv272243 CNV Insertion 20981092

Variation tolerance for ALG5 Gene

Residual Variation Intolerance Score: 61.06% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.00; 20.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ALG5 Gene

HapMap Linkage Disequilibrium report
ALG5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for ALG5 Gene

Disorders for ALG5 Gene

Relevant External Links for ALG5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ALG5
genes like me logo Genes that share disorders with ALG5: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ALG5 Gene

Publications for ALG5 Gene

  1. A mutation in the human ortholog of the Saccharomyces cerevisiae ALG6 gene causes carbohydrate-deficient glycoprotein syndrome type-Ic. (PMID: 10359825) Imbach T. … Hennet T. (Proc. Natl. Acad. Sci. U.S.A. 1999) 2 23 67
  2. A genetic system based on split-ubiquitin for the analysis of interactions between membrane proteins in vivo. (PMID: 9560251) Stagljar I. … te Heesen S. (Proc. Natl. Acad. Sci. U.S.A. 1998) 23 67
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  4. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome A.S. … Carapito C. (Proteomics 2015) 67
  5. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 67

Products for ALG5 Gene

Sources for ALG5 Gene

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