Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ALG3 Gene

protein-coding   GIFtS: 58
GCID: GC03M183960

ALG3, Alpha-1,3- Mannosyltransferase

(Previous names: asparagine-linked glycosylation 3 homolog (yeast, alpha-1,3-mannosyltransferase),...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
ALG3, Alpha-1,3- Mannosyltransferase1 2     Asparagine-Linked Glycosylation 3, Alpha-1,3- Mannosyltransferase Homolog
(S. Cerevisiae)1
NOT56L2 3 5     Dol-P-Man Dependent Alpha-11
Asparagine-Linked Glycosylation 3 Homolog (Yeast,
Alpha-1,3-Mannosyltransferase)1 2
     Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol Alpha-11
Carbohydrate Deficient Glycoprotein Syndrome Type IV1 2     D16Ertd36e2
Asparagine-Linked Glycosylation Protein 3 Homolog2 3     Not562
Dol-P-Man-Dependent Alpha(1-3)-Mannosyltransferase2 3     Asparagine-Linked Glycosylation 3 Homolog (S. Cerevisiae,
Alpha-1,3-Mannosyltransferase)2
Dolichyl-P-Man:Man(5)GlcNAc(2)-PP-Dolichyl Mannosyltransferase2 3     Asparagine-Linked Glycosylation 3, Alpha-1,3- Mannosyltransferase Homolog2
Dolichyl-Phosphate-Mannose--Glycolipid Alpha-Mannosyltransferase2 3     Dol-P-Man Dependent Alpha(1-3)-Mannosyltransferase2
Not56-Like Protein2 3     Dol-P-Man Dependent Alpha-1,3- Mannosyltransferase2
CDG1D2 5     Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol Alpha-1,3-Mannosyltransferase2
CDGS42 5     EC 2.4.1.2583
3- Mannosyltransferase1     NOT3
3-mannosyltransferase1     EC 2.4.1.1308

External Ids:    HGNC: 230561   Entrez Gene: 101952   Ensembl: ENSG000002141607   OMIM: 6087505   UniProtKB: Q926853   

Export aliases for ALG3 gene to outside databases

Previous GC identifers: GC03M185281 GC03M185442 GC03M181367


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ALG3 Gene:
This gene encodes a member of the ALG3 family. The encoded protein catalyses the addition of the first dol-P-Man
derived mannose in an alpha 1,3 linkage to Man5GlcNAc2-PP-Dol. Defects in this gene have been associated with
congenital disorder of glycosylation type Id (CDG-Id) characterized by abnormal N-glycosylation. Multiple
transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Nov 2008)

GeneCards Summary for ALG3 Gene: 
ALG3 (ALG3, alpha-1,3- mannosyltransferase) is a protein-coding gene. Diseases associated with ALG3 include congenital disorder of glycosylation type 1d, and congenital disorder of glycosylation, and among its related super-pathways are WNT ligand biogenesis and trafficking and Synthesis of substrates in N-glycan biosythesis. GO annotations related to this gene include alpha-1,3-mannosyltransferase activity and dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity.

UniProtKB/Swiss-Prot: ALG3_HUMAN, Q92685
Function: Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man5GlcNAc2-PP-Dol

Gene Wiki entry for ALG3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.2  NT_005612.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ALG3 gene promoter:
         E2F-3a   E2F-4   E2F   E2F-1   E2F-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ALG3 promoter sequence
   Search SABiosciences Chromatin IP Primers for ALG3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ALG3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q27.1   Ensembl cytogenetic band:  3q27.1   HGNC cytogenetic band: 3q27.3

ALG3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ALG3 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M183960:  view genomic region     (about GC identifiers)

Start:
183,960,089 bp from pter      End:
183,967,336 bp from pter
Size:
7,248 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ALG3_HUMAN, Q92685 (See protein sequence)
Recommended Name: Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase  
Size: 438 amino acids; 50126 Da
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein (Probable)
Secondary accessions: A8JZZ6 Q9BT71
Alternative splicing: 2 isoforms:  Q92685-1   Q92685-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ALG3: NX_Q92685

Explore proteomics data for ALG3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q92685

  • 4 DME Specific Peptides for ALG3 (Q92685)
     VLRLFND  RSLHYQF  WTVNWRF  TGPLVYP 

    ALG3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ALG3 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001006942.1  NP_005778.1  

    ENSEMBL proteins: 
     ENSP00000394917   ENSP00000380793   ENSP00000402744   ENSP00000397613   ENSP00000397326  
     ENSP00000392209   ENSP00000407011   ENSP00000402976  
    Reactome Protein details: Q92685
    Human Recombinant Protein Products for ALG3: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for ALG3
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for ALG3
    GenScript Custom Purified and Recombinant Proteins Services for ALG3
    Novus Biologicals ALG3 Protein
    Novus Biologicals ALG3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ALG3 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum ----
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0016021integral to membrane IEA--

    ALG3 for ontologies           About GeneDecksing



    ALG3 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for ALG3
    GenScript Custom Superior Antibodies Services for ALG3
    Novus Biologicals ALG3 Antibody
    Abcam antibodies for ALG3
    Cloud-Clone Corp. Antibodies for ALG3 
    Search ThermoFisher Antibodies for ALG3
    Search LSBio for Antibodies for ALG3 

    Assay Products for ALG3: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ALG3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ALG3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ALG3 
    Cloud-Clone Corp. CLIAs for ALG3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    DOLPM: Dolichyl D-mannosyl phosphate dependent mannosyltransferases

    1 InterPro protein domain:
     IPR007873 Glycosyltransferase_ALG3

    Graphical View of Domain Structure for InterPro Entry Q92685

    ProtoNet protein and cluster: Q92685

    1 Blocks protein domain: IPB007873 ALG3

    UniProtKB/Swiss-Prot: ALG3_HUMAN, Q92685
    Similarity: Belongs to the glycosyltransferase 58 family


    ALG3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ALG3_HUMAN, Q92685
    Function: Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man5GlcNAc2-PP-Dol
    Catalytic activity: Dolichyl beta-D-mannosyl phosphate +
    D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol
    =
    D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->3)-D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol
    + dolichyl phosphate

         Enzyme Numbers (IUBMB): EC 2.4.1.2581 EC 2.4.1.1302

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000033alpha-1,3-mannosyltransferase activity IDA10581255
    GO:0016758transferase activity, transferring hexosyl groups ----
    GO:0052925dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity IEA--
         
    ALG3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ALG3:
     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ALG3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ALG3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ALG3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ALG3 

    miRNA
    Products:
        
    miRTarBase miRNAs that target ALG3:
    hsa-let-7b (MIRT005225), hsa-mir-16 (MIRT005258)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ALG3
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ALG3
    SwitchGear 3'UTR luciferase reporter plasmidALG3 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ALG3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ALG3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ALG3
    Sirion Biotech Customized adenovirus for overexpression of ALG3

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for ALG3 (see all 13)
    OriGene ORF clones in mouse, rat for ALG3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ALG3 (NM_005787)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ALG3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALG3
    Sirion Biotech Customized lentivirus for stable overexpression of ALG3 
                         Customized lentivirus expression plasmids for stable overexpression of ALG3 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ALG3
    Search LifeMap BioReagents cell lines for ALG3
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALG3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ALG3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Asparagine N-linked glycosylation
    Asparagine N-linked glycosylation0.77
    N-Glycan biosynthesis0.52
    WNT ligand biogenesis and trafficking0.77
    Post-translational protein modification0.44
    Signaling by Wnt0.62
    Metabolism of proteins0.35
    2Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein0.53
    dolichyl-diphosphooligosaccharide biosynthesis0.30
    3Signaling by GPCR
    Signal Transduction0.55
    4Metabolism
    Metabolic pathways0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for ALG3
        dolichyl-diphosphooligosaccharide biosynthesis

    5/7        Reactome Pathways for ALG3 (see all 7)
        Signaling by Wnt
    Asparagine N-linked glycosylation
    Signal Transduction
    Metabolism of proteins
    Post-translational protein modification


    2         Kegg Pathways  (Kegg details for ALG3):
        N-Glycan biosynthesis
    Metabolic pathways

    UniProtKB/Swiss-Prot: ALG3_HUMAN, Q92685
    Pathway: Protein modification; protein glycosylation


    ALG3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ALG3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/48 Interacting proteins for ALG3 (Q926853 ENSP000003807934) via UniProtKB, MINT, STRING, and/or I2D (see all 48)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    POLR2IP369543, ENSP000002218594I2D: score=3 STRING: ENSP00000221859
    DDOSTP396563, ENSP000003641884I2D: score=2 STRING: ENSP00000364188
    ALG12Q9BV103, ENSP000003338134I2D: score=1 STRING: ENSP00000333813
    ALG5Q9Y6733, ENSP000002398914I2D: score=1 STRING: ENSP00000239891
    ALG8Q9BVK23, ENSP000002996264I2D: score=1 STRING: ENSP00000299626
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006486protein glycosylation NAS10581255
    GO:0006488dolichol-linked oligosaccharide biosynthetic process TAS--
    GO:0018279protein N-linked glycosylation via asparagine TAS--
    GO:0043687post-translational protein modification TAS--
    GO:0044267cellular protein metabolic process TAS--

    ALG3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ALG3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ALG3

    1 HMDB Compound for ALG3    About this table
    CompoundSynonyms CAS #PubMed Ids
    D-MannoseDL-mannose (see all 13)3458-28-4--

    1 Novoseek inferred chemical compound relationship for ALG3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    man5glcnac2-p-p-dolichol 96.2 1 2005096 (1)

    Search CenterWatch for drugs/clinical trials and news about ALG3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ALG3 gene (3 alternative transcripts): 
    NM_001006941.2  NM_005787.5  NM_001006940.1  

    Unigene Cluster for ALG3:

    ALG3, alpha-1,3- mannosyltransferase
    Hs.478481  [show with all ESTs]
    Unigene Representative Sequence: NM_001006941
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000411922 ENST00000397676(uc003fne.2 uc011brc.1 uc011brd.1)
    ENST00000445626(uc011bre.1) ENST00000485912 ENST00000455059 ENST00000446569
    ENST00000414845 ENST00000463495 ENST00000462735 ENST00000423996 ENST00000477959
    ENST00000461415 ENST00000488976(uc011brf.1) ENST00000482048 ENST00000418734

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ALG3
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ALG3
    SwitchGear 3'UTR luciferase reporter plasmidALG3 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ALG3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ALG3
    Clone
    Products:
         
    OriGene clones in human, mouse for ALG3 (see all 13)
    OriGene ORF clones in mouse, rat for ALG3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ALG3 (NM_005787)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ALG3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALG3
    Sirion Biotech Customized lentivirus for stable overexpression of ALG3 
                         Customized lentivirus expression plasmids for stable overexpression of ALG3 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ALG3
    OriGene qSTAR qPCR primer pairs in human, mouse for ALG3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ALG3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ALG3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ALG3

    Additional mRNA sequence: 

    AK289361.1 AK299575.1 BC002839.2 BC004313.1 BC021062.1 NR_024533.1 NR_024534.1 Y09022.1 

    11 DOTS entries:

    DT.412755  DT.95365865  DT.100807677  DT.95365868  DT.91756953  DT.40261099  DT.95365861  DT.40263277 
    DT.95365856  DT.95365853  DT.95365866 

    24/269 AceView cDNA sequences (see all 269):

    BU540730 CR619480 AI313444 BQ927823 BI261961 BG750859 BC002839 BU553862 
    CR594345 CR593059 CR620598 CR616285 BQ053899 AL555582 BU161837 AW513290 
    CR603692 CR611890 BU543950 BE313598 BQ184771 BG284392 BI195605 BI226899 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ALG3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCGTCATCCT
    ALG3 Expression
    About this image


    See ALG3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ALG3

    SOURCE GeneReport for Unigene cluster: Hs.478481
        SABiosciences Custom PCR Arrays for ALG3
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for ALG3
    OriGene qSTAR qPCR primer pairs in human, mouse for ALG3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ALG3
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ALG3
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ALG3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALG3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ALG3 gene from 9/22 species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Alg31 , 5 asparagine-linked glycosylation 3 homolog (yeast, alpha-1,3-mannosyltransferase)5
    asparagine-linked glycosylation 3 (alpha-1,3-mannosyltransferase)1
    86.76(n)1
    88.81(a)1
      16 (12.48 cM)5
    2086241  NM_145939.21  NP_666051.21 
     206054515 
    chicken
    (Gallus gallus)
    Aves ALG31 asparagine-linked glycosylation 3, alpha-1,3- mannosyltransferase more 74.07(n)
    73.58(a)
      424952  XM_422759.3  XP_422759.3 
    lizard
    (Anolis carolinensis)
    Reptilia ALG36
    Uncharacterized protein
    71(a)
    1 ↔ 1
    GL343245.1(631503-639595)
    zebrafish
    (Danio rerio)
    Actinopterygii alg31 asparagine-linked glycosylation 3 homolog (S. cerevisiae, more 64.11(n)
    66.59(a)
      553725  NM_001020696.1  NP_001018532.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta l(2)not1 lethal (2) neighbor of tid 59.98(n)
    56.45(a)
      37754  NM_079105.3  NP_523829.2 
    worm
    (Caenorhabditis elegans)
    Secernentea K09E4.21 Protein K09E4.2 53.58(n)
    51.08(a)
      175065  NM_064549.4  NP_496950.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ALG31 Alg3p 48.02(n)
    38.14(a)
      852196   NP_009471.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ALG31 alpha-1,3-mannosyltransferase 50.13(n)
    48.04(a)
      819388  NM_130343.3  NP_182297.1 
    rice
    (Oryza sativa)
    Liliopsida Os.161842 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 74.85(n)    AK068405.1 


    ENSEMBL Gene Tree for ALG3 (if available)
    TreeFam Gene Tree for ALG3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ALG3 gene

    ALG3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ALG3
    PGOHUM00000235111


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/284 SNPs in ALG3 are shown (see all 284)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0378064
    Congenital disorder of glycosylation 1D (CDG1D)4--see VAR_0378062 R Q mis40--------
    rs289405881,2,4
    CCongenital disorder of glycosylation 1D (CDG1D)4 pathogenic1183829469(-) CCGAGA/GCACTG 6 D G mis10--------
    rs1191032361,2
    Cpathogenic1183829201(-) GCTGCA/GGCTCT 6 Q R mis10--------
    rs1113893901,2
    C--181375863(+) AAAAG-/AAAAGA 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1474091441,2
    --183825761(+) ATGCGC/GCGCTG 4 -- ds50010--------
    rs617405441,2
    F--183825786(+) GAACTG/AACAGC 4 -- ds50012Minor allele frequency- A:0.02NS CSA 80
    rs1846303851,2
    --183825832(+) TGCCTG/TACGGC 4 -- ds50010--------
    rs29420491,2
    H--183826003(+) CACTGT/CCGCCC 4 -- ds50013Minor allele frequency- C:0.00EA NS 288
    rs775498121,2
    F--183826005(+) CTGCCA/GCCCAG 4 -- ds50010--------
    rs1807290551,2
    C--183826022(+) CCTCTC/TGGTGC 4 -- ds50010--------

    HapMap Linkage Disequilibrium report for ALG3 (183960089 - 183967336 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for ALG3:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv878060CNV Loss21882294
    dgv5354n71CNV Loss21882294
    nsv829812CNV Loss17160897
    nsv528639CNV Loss19592680
    nsv878057CNV Loss21882294


    Human Gene Mutation Database (HGMD): ALG3

    Locus Specific Mutation Databases (LSDB): ALG3
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing ALG3
    DNA2.0 Custom Variant and Variant Library Synthesis for ALG3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608750   
    OMIM disorders: 601110  
    UniProtKB/Swiss-Prot: ALG3_HUMAN, Q92685
  • Congenital disorder of glycosylation 1D (CDG1D) [MIM:601110]: A multisystem disorder caused by a defect
    in glycoprotein biosynthesis and characterized by under-glycosylated serum glycoproteins. Congenital disorders of
    glycosylation result in a wide variety of clinical features, such as defects in the nervous system development,
    psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad
    spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation,
    and maintenance of cell functions. Note=The disease is caused by mutations affecting the gene represented in this
    entry

  • 6 diseases for ALG3:    About MalaCards
    congenital disorder of glycosylation type 1d    congenital disorder of glycosylation    hyperinsulinemic hypoglycemia    hypoglycemia
    microcephaly    major depressive disorder

    2 diseases from the University of Copenhagen DISEASES database for ALG3:
    Congenital disorder of glycosylation     Microcephaly

    ALG3 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for ALG3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    congenital disorders 81.7 2 16053906 (1), 15108280 (1)

    GeneTests: ALG3
    GeneReviews: ALG3

    Export disorders for ALG3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ALG3 gene, integrated from 9 sources (see all 28):
    (articles sorted by number of sources associating them with ALG3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Carbohydrate deficient glycoprotein syndrome type IV: deficiency of dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase. (PubMed id 10581255)1, 2, 9 Koerner C....von Figura K. (1999)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Will an electric current replace the syringe for anesthesia? (PubMed id 1058125)1, 3 Jerrold L.E. (1975)
    4. An activated 5' cryptic splice site in the human ALG3 gene generates a premature termination codon insensitive to nonsense-mediated mRNA decay in a new case of congenital disorder of glycosylation type Id (CDG-Id). (PubMed id 15108280)1, 9 Denecke J....Marquardt T. (2004)
    5. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    6. A mega-analysis of genome-wide association studies for major depressive disorder. (PubMed id 22472876)1 (2012)
    7. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    8. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    9. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    10. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10195 HGNC: 23056 AceView: ALG3 Ensembl:ENSG00000214160 euGenes: HUgn10195
    ECgene: ALG3 Kegg: 10195 H-InvDB: ALG3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ALG3 Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/ALG3
    GGDBhttp://riodb.ibase.aist.go.jp/rcmg/ggdb/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ALG3 gene:
    Search GeneIP for patents involving ALG3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for ALG3  
     OriGene qPCR primer pairs and template standards for ALG3   OriGene Protein Over-expression Lysate for ALG3  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for ALG3  
     OriGene qSTAR qPCR primer pairs in human, mouse for ALG3   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for ALG3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ALG3   OriGene Custom Protein Services for ALG3  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ALG3
     QIAGEN SeqTarget long-range PCR primers for resequencing ALG3
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ALG3
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ALG3
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ALG3
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ALG3
     GenScript Custom Purified and Recombinant Proteins Services for ALG3 GenScript cDNA clones with any tag delivered in your preferred vector for ALG3
     GenScript Custom Assay Services for ALG3 GenScript Custom Superior Antibodies Services for ALG3
     GenScript Custom overexpressing Cell Line Services for ALG3 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in ALG3 promoter
     Search Chromatin IP Primers for ALG3
     RT2 qPCR Primer Assay in human, mouse, rat ALG3
     Search GNC Networks for ALG3
     SABiosciences Custom PCR Arrays for ALG3
     Search Tocris compounds for ALG3
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     ALG3 antibodies
     ALG3 proteins
     ALG3 lysates
     Antibodies for ALG3
     See all of Abcam's Antibodies, Kits and Proteins for ALG3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for ALG3
     Antibodies for ALG3
     ELISAs for ALG3
     CLIAs for ALG3
     Search LifeMap BioReagents cell lines for ALG3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALG3
     SwitchGear 3'UTR luciferase reporter plasmids for ALG3
     SwitchGear Promoter luciferase reporter plasmids for ALG3
     Search ThermoFisher Antibodies for ALG3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALG3
     inGenious Targeting Laboratory - Custom generated mouse model solutions for ALG3
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ALG3
    Customized:
     lentivirus for stable overexpression of ALG3
     lentivirus expression plasmids for stable overexpression of ALG3
     adenovirus for overexpression of ALG3
     Search LSBio for Antibodies for ALG3
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ALG3 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4