ALG3 Gene
protein-coding GIFtS: 59
GCID: GC03M183960
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|
ALG3, alpha-1,3- mannosyltransferase(Previous names: asparagine-linked glycosylation 3 homolog (yeast, alpha-1,3-mannosyltransferase),...)
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Aliases
for ALG3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| ALG3, Alpha-1,3- Mannosyltransferase1 2 | | CDG1D2 5 | | NOT56L1 2 3 5 | | Asparagine-Linked Glycosylation 3, Alpha-1,3- Mannosyltransferase Homolog (S.Cerevisiae)1 | | CDGS41 2 5 | | Asparagine-Linked Glycosylation 3 Homolog (S. Cerevisiae,Alpha-1,3-Mannosyltransferase)2 | | D16Ertd36e1 2 | | Asparagine-Linked Glycosylation 3, Alpha-1,3- Mannosyltransferase Homolog2 | | Not561 2 | | Carbohydrate Deficient Glycoprotein Syndrome Type IV2 | | Asparagine-Linked Glycosylation 3 Homolog (Yeast,Alpha-1,3-Mannosyltransferase)1 2 | | Dol-P-Man Dependent Alpha(1-3)-Mannosyltransferase2 | | Asparagine-Linked Glycosylation Protein 3 Homolog2 3 | | Dol-P-Man Dependent Alpha-1,3- Mannosyltransferase2 | | Dol-P-Man-Dependent Alpha(1-3)-Mannosyltransferase2 3 | | Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol Alpha-1,3-Mannosyltransferase2 | | Dolichyl-P-Man:Man(5)GlcNAc(2)-PP-Dolichyl Mannosyltransferase2 3 | | EC 2.4.1.2583 | | Dolichyl-Phosphate-Mannose--Glycolipid Alpha-Mannosyltransferase2 3 | | NOT3 | | Not56-Like Protein2 3 | | EC 2.4.1.1308 |
Export aliases for ALG3 gene to outside databasesPrevious GC identifers: GC03M185281 GC03M185442 GC03M181367 |
Summaries
for ALG3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ALG3:
This gene encodes a member of the ALG3 family. The encoded protein catalyses the addition of the first dol-P-Manderived mannose in an alpha 1,3 linkage to Man5GlcNAc2-PP-Dol. Defects in this gene have been associated withcongenital disorder of glycosylation type Id (CDG-Id) characterized by abnormal N-glycosylation. Multiple transcriptvariants encoding different isoforms have been found for this gene. (provided by RefSeq, Nov 2008)
UniProtKB/Swiss-Prot: ALG3_HUMAN, Q92685Function: Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man5GlcNAc2-PP-Dol
Gene Wiki entry for ALG3
|
Genomic Views
for ALG3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_005612.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ALG3 gene promoter:
E2F-3a E2F-4 E2F E2F-1 E2F-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for ALG3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ALG3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q27.1 Ensembl cytogenetic band: 3q27.1 HGNC cytogenetic band: 3q27.3ALG3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03M183960: view genomic region
(about GC identifiers)
Start:
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183,960,089 bp from pter |
End:
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183,967,336 bp from pter |
Size:
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7,248 bases |
Orientation:
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minus strand |
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Proteins
for ALG3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ALG3_HUMAN, Q92685 (See
protein sequence)Recommended Name: Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase Size: 438 amino acids; 50126 Da
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein (Probable)
Secondary accessions: A8JZZ6 Q9BT71Alternative splicing: 2 isoforms: Q92685-1 Q92685-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for ALG3: NX_Q92685
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q92685
4 DME Specific Peptides for ALG3 (Q92685)
ALG3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001006942.1 NP_005778.1
ENSEMBL proteins: ENSP00000394917 ENSP00000380793 ENSP00000402744 ENSP00000397613 ENSP00000397326 ENSP00000392209 ENSP00000407011 ENSP00000402976 Reactome Protein details: Q92685
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005783 | endoplasmic reticulum |
-- | -- | | GO:0005789 | endoplasmic reticulum membrane |
TAS | -- | | GO:0016021 | integral to membrane |
IEA | -- |
ALG3 for ontologies About GeneDecksing
ALG3 Antibody Products:
Assay Products for ALG3: |
Protein
Domains /
Families
for ALG3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ALG3 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q92685ProtoNet protein and cluster: Q92685 1 Blocks protein family: IPB007873 ALG3
UniProtKB/Swiss-Prot: ALG3_HUMAN, Q92685Similarity: Belongs to the glycosyltransferase 58 family |
Function
for ALG3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ALG3_HUMAN, Q92685Function: Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man5GlcNAc2-PP-DolCatalytic activity: Dolichyl beta-D-mannosyl phosphate +D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol=D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->3)-D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol+ dolichyl phosphateEnzyme Numbers (IUBMB): EC 2.4.1.2581 EC 2.4.1.1302
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ALG3 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ALG3 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): ALG3 (NM_005787) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ALG3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALG3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALG3 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000033 | alpha-1,3-mannosyltransferase activity |
IDA | 10581255 | | GO:0016758 | transferase activity, transferring hexosyl groups |
-- | -- | | GO:0052925 | dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity |
IEA | -- |
ALG3 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for ALG3:
|
Pathways & Interactions
for ALG3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Asparagine N-linked glycosylation | | | 2 | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein | | | 3 | Metabolism | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1  BioSystems Pathway for ALG3
4 
Reactome Pathways for ALG3
2 
Kegg Pathways (Kegg details for ALG3):
UniProtKB/Swiss-Prot: ALG3_HUMAN, Q92685Pathway: Protein modification; protein glycosylation
ALG3 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ALG3
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/48 Interacting proteins for ALG3 (Q926853 ENSP000003807934) via UniProtKB, MINT, STRING, and/or I2D (see all 48)
About this table
Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006486 | protein glycosylation |
NAS | 10581255 | | GO:0006488 | dolichol-linked oligosaccharide biosynthetic process |
TAS | -- | | GO:0018279 | protein N-linked glycosylation via asparagine |
TAS | -- | | GO:0043687 | post-translational protein modification |
TAS | -- | | GO:0044267 | cellular protein metabolic process |
TAS | -- |
ALG3 for ontologies About GeneDecksing
|
Drugs & Compounds
for ALG3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
ALG3 for compounds About GeneDecksing
 Browse Tocris compounds for ALG3
1 HMDB Compound for ALG3 About this table
1 Novoseek chemical compound relationship for ALG3 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| man5glcnac2-p-p-dolichol |
96.2 |
1 |
2005096 (1) |
Search CenterWatch for drugs/clinical trials and news about ALG3
|
Transcripts
for ALG3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ALG3 gene (3 alternative transcripts): NM_001006941.2 NM_005787.5 NM_001006940.1 Unigene Cluster for ALG3: Asparagine-linked glycosylation 3, alpha-1,3- mannosyltransferase homolog (S. cerevisiae) Hs.478481 [show with all ESTs]Unigene Representative Sequence: NM_00100694115 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000411922 ENST00000397676(uc003fne.2 uc011brc.1 uc011brd.1)
ENST00000445626(uc011bre.1) ENST00000485912 ENST00000455059 ENST00000446569
ENST00000414845 ENST00000463495 ENST00000462735 ENST00000423996 ENST00000477959
ENST00000461415 ENST00000488976(uc011brf.1) ENST00000482048 ENST00000418734
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ALG3 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ALG3 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): ALG3 (NM_005787) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ALG3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALG3 |
Additional cDNA sequence: AK289361.1 AK299575.1 BC002839.2 BC004313.1 BC021062.1 NR_024533.1 NR_024534.1 Y09022.1 11 DOTS entries: DT.412755 DT.95365865 DT.100807677 DT.95365868 DT.91756953 DT.40261099 DT.95365861 DT.40263277 DT.95365856 DT.95365853 DT.95365866 24/269 AceView cDNA sequences (see all 269): AI081403 CR619480 BQ184771 AL555582 BQ927823 BM557180 BM763044 BG750859 CR596636 BI223346 NM_005787 BG284392 BE313598 BI226899 BU552851 CR620912 BE251285 BE313728 BE273591 BM920198 BU540730 AI313444 BU543950 BQ958872
GeneLoc Exon Structure
|
Expression
for ALG3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ALG3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCGTCATCCT
About this image
See ALG3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ALG3
SOURCE GeneReport for Unigene cluster: Hs.478481
SABiosciences Custom PCR Arrays for ALG3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ALG3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ALG3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ALG3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ALG3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALG3 |
Orthologs
for ALG3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for ALG3 gene from 9/29 species (see all 29) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Alg31 , 5 |
asparagine-linked glycosylation 3 homolog (yeast, alpha-1,3-mannosyltransferase)5
asparagine-linked glycosylation 3 (alpha-1,3-mannosyltransferase)1 |
86.76(n)1
88.81(a)1 |
|
16 (12.48 cM)5
2086241 NM_145939.21 NP_666051.21
206054515 |
chicken
(Gallus gallus) |
Aves |
ALG31 |
asparagine-linked glycosylation 3, alpha-1,3- mannosyltransferase more |
74.07(n)
73.58(a) |
|
424952 XM_422759.3 XP_422759.3 |
lizard
(Anolis carolinensis) |
Reptilia |
ALG36 |
-- |
71(a) |
1 ↔ 1 |
GL343245.1(631503-639595) |
zebrafish
(Danio rerio) |
Actinopterygii |
alg31 |
asparagine-linked glycosylation 3 homolog (S. cerevisiae, more |
64.11(n)
66.59(a) |
|
553725 NM_001020696.1 NP_001018532.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
l(2)not1 |
lethal (2) neighbor of tid |
59.98(n)
56.45(a) |
|
37754 NM_079105.3 NP_523829.2 |
worm
(Caenorhabditis elegans) |
Secernentea |
K09E4.21 |
Protein K09E4.2 |
53.58(n)
51.08(a) |
|
175065 NM_064549.4 NP_496950.2 |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
ALG31 |
Alg3p |
48.02(n)
38.14(a) |
|
852196 NP_009471.1 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
ALG31 |
alpha-1,3-mannosyltransferase |
50.13(n)
48.04(a) |
|
819388 NM_130343.3 NP_182297.1 |
rice
(Oryza sativa) |
Liliopsida |
Os.161842 |
Oryza sativa (japonica cultivar-group) cDNA cloneJ more |
74.85(n) |
|
AK068405.1 |
ENSEMBL Gene Tree for ALG3 (if available)
TreeFam Gene Tree for ALG3 (if available) |
Paralogs
for ALG3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ALG3 gene
ALG3 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for ALG3
PGOHUM00000235111
|
Genomic Variants
for ALG3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ALG3 (183960089 - 183967336 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ALG3
1 CNV: 4364
Human Gene Mutation Database (HGMD): ALG3
Locus Specific Mutation Databases (LSDB): ALG3
| SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for ALG3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ALG3 for disorders About GeneDecksing
OMIM gene information: 608750
OMIM disorders: 601110
UniProtKB/Swiss-Prot: ALG3_HUMAN, Q92685
Defects in ALG3 are the cause of congenital disorder of glycosylation type 1D (CDG1D) [MIM:601110]; also knownas carbohydrate-deficient glycoprotein syndrome type IV (CDGS4). CDGs are metabolic deficiencies in glycoproteinbiosynthesis that usually cause severe mental and psychomotor retardation. They are characterized byunder-glycosylated serum glycoproteins
5  diseases for ALG3: About MalaCardscongenital disorder of glycosylation congenital disorder of glycosylation type 1d hyperinsulinemic hypoglycemia hypoglycemia
microcephaly
2 diseases from the University of Copenhagen DISEASES database for ALG3:Congenital disorder of glycosylation Microcephaly 1 Novoseek disease relationship for ALG3 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| congenital disorders |
81.7 |
2 |
16053906 (1), 15108280 (1) |
GeneTests: ALG3
Congenital Disorders of Glycosylation
Export disorders for ALG3 gene to outside databases
|
Publications
for ALG3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ALG3 gene, integrated from 9 sources (see all 27):
(articles sorted by number of sources associating them with ALG3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Carbohydrate deficient glycoprotein syndrome type IV: deficiency of dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase. (PubMed id 10581255)1, 2, 9 Koerner C....von Figura K. (1999)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Will an electric current replace the syringe for anesthesia? (PubMed id 1058125)1, 3 Jerrold L.E. (1975)
- An activated 5' cryptic splice site in the human ALG3 gene generates a premature termination codon insensitive to nonsense-mediated mRNA decay in a new case of congenital disorder of glycosylation type Id (CDG-Id). (PubMed id 15108280)1, 9 Denecke J....Marquardt T. (2004)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- A mega-analysis of genome-wide association studies for major depressive disorder. (PubMed id 22472876)1 (2012)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
|
External Searches for ALG3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ALG3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing ALG3 gene
(According to HUGE)
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Specialized Databases showing ALG3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for ALG3 | Pharmacogenomics, SNPs, Pathways | | GeneReviews | http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/ALG3 | | GGDB | http://riodb.ibase.aist.go.jp/rcmg/ggdb/ |
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| Patent Information for ALG3 gene:
Search GeneIP for patents involving ALG3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for ALG3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ALG3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ALG3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ALG3 | | | OriGene Protein Over-expression Lysate for ALG3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ALG3 | | OriGene 3'-UTR Clone for ALG3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ALG3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ALG3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ALG3 | | OriGene Custom Protein Services for ALG3 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ALG3 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ALG3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ALG3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ALG3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ALG3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ALG3 |
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| | | | Search Tocris compounds for ALG3 |
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 | | | ALG3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALG3 |
|  |  |  | | | | Search ThermoFisher Antibodies for ALG3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALG3 |
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