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Aliases for ALG3 Gene

Aliases for ALG3 Gene

  • ALG3, Alpha-1,3- Mannosyltransferase 2 3
  • NOT56L 3 4 6
  • Asparagine-Linked Glycosylation 3 Homolog (Yeast, Alpha-1,3-Mannosyltransferase) 2 3
  • Dolichyl-Phosphate-Mannose--Glycolipid Alpha-Mannosyltransferase 3 4
  • Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol Alpha-1,3-Mannosyltransferase 2 3
  • Dolichyl-P-Man:Man(5)GlcNAc(2)-PP-Dolichyl Mannosyltransferase 3 4
  • Carbohydrate Deficient Glycoprotein Syndrome Type IV 2 3
  • Dol-P-Man Dependent Alpha-1,3- Mannosyltransferase 2 3
  • Dol-P-Man-Dependent Alpha(1-3)-Mannosyltransferase 3 4
  • Asparagine-Linked Glycosylation Protein 3 Homolog 3 4
  • Not56-Like Protein 3 4
  • CDG1D 3 6
  • CDGS4 3 6
  • Asparagine-Linked Glycosylation 3, Alpha-1,3- Mannosyltransferase Homolog (S. Cerevisiae) 2
  • Asparagine-Linked Glycosylation 3 Homolog (S. Cerevisiae, Alpha-1,3-Mannosyltransferase) 3
  • Asparagine-Linked Glycosylation 3, Alpha-1,3- Mannosyltransferase Homolog 3
  • Dol-P-Man Dependent Alpha(1-3)-Mannosyltransferase 3
  • EC 63
  • EC 4
  • D16Ertd36e 3
  • Not56 3
  • NOT 4

External Ids for ALG3 Gene

Previous GeneCards Identifiers for ALG3 Gene

  • GC03M185281
  • GC03M185442
  • GC03M183960
  • GC03M181367

Summaries for ALG3 Gene

Entrez Gene Summary for ALG3 Gene

  • This gene encodes a member of the ALG3 family. The encoded protein catalyses the addition of the first dol-P-Man derived mannose in an alpha 1,3 linkage to Man5GlcNAc2-PP-Dol. Defects in this gene have been associated with congenital disorder of glycosylation type Id (CDG-Id) characterized by abnormal N-glycosylation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]

GeneCards Summary for ALG3 Gene

ALG3 (ALG3, Alpha-1,3- Mannosyltransferase) is a Protein Coding gene. Diseases associated with ALG3 include congenital disorder of glycosylation, type id and hyperinsulinemic hypoglycemia. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include alpha-1,3-mannosyltransferase activity and dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity.

UniProtKB/Swiss-Prot for ALG3 Gene

  • Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man5GlcNAc2-PP-Dol.

Gene Wiki entry for ALG3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ALG3 Gene

Genomics for ALG3 Gene

Regulatory Elements for ALG3 Gene

Genomic Location for ALG3 Gene

184,242,301 bp from pter
184,249,548 bp from pter
7,248 bases
Minus strand

Genomic View for ALG3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ALG3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ALG3 Gene

Proteins for ALG3 Gene

  • Protein details for ALG3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase
    Protein Accession:
    Secondary Accessions:
    • A8JZZ6
    • Q9BT71

    Protein attributes for ALG3 Gene

    438 amino acids
    Molecular mass:
    50126 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ALG3 Gene


neXtProt entry for ALG3 Gene

Proteomics data for ALG3 Gene at MOPED

Selected DME Specific Peptides for ALG3 Gene

Post-translational modifications for ALG3 Gene

  • Ubiquitination at Lys22
  • Modification sites at PhosphoSitePlus

Other Protein References for ALG3 Gene

Domains for ALG3 Gene

Gene Families for ALG3 Gene

  • DOLPM :Dolichyl D-mannosyl phosphate dependent mannosyltransferases

Protein Domains for ALG3 Gene


Graphical View of Domain Structure for InterPro Entry



  • Q92685
  • Belongs to the glycosyltransferase 58 family.
genes like me logo Genes that share domains with ALG3: view

Function for ALG3 Gene

Molecular function for ALG3 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Dolichyl beta-D-mannosyl phosphate + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->3)-D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate
UniProtKB/Swiss-Prot Function: Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man5GlcNAc2-PP-Dol.

Enzyme Numbers (IUBMB) for ALG3 Gene

Gene Ontology (GO) - Molecular Function for ALG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000033 alpha-1,3-mannosyltransferase activity IDA 10581255
GO:0016758 transferase activity, transferring hexosyl groups --
GO:0052925 dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity IEA --
genes like me logo Genes that share ontologies with ALG3: view

Phenotypes for ALG3 Gene

GenomeRNAi human phenotypes for ALG3:
genes like me logo Genes that share phenotypes with ALG3: view

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for ALG3 Gene

Localization for ALG3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ALG3 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for ALG3 Gene COMPARTMENTS Subcellular localization image for ALG3 gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 3
nucleus 1

Gene Ontology (GO) - Cellular Components for ALG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ALG3: view

Pathways for ALG3 Gene

genes like me logo Genes that share pathways with ALG3: view

UniProtKB/Swiss-Prot Q92685-ALG3_HUMAN

  • Pathway: Protein modification; protein glycosylation

Gene Ontology (GO) - Biological Process for ALG3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006486 protein glycosylation NAS 10581255
GO:0006488 dolichol-linked oligosaccharide biosynthetic process TAS --
GO:0008152 metabolic process --
GO:0018279 protein N-linked glycosylation via asparagine TAS --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with ALG3: view

Compounds for ALG3 Gene

(1) HMDB Compounds for ALG3 Gene

Compound Synonyms Cas Number PubMed IDs
  • DL-mannose

(1) Novoseek inferred chemical compound relationships for ALG3 Gene

Compound -log(P) Hits PubMed IDs
man5glcnac2-p-p-dolichol 96.2 1
genes like me logo Genes that share compounds with ALG3: view

Transcripts for ALG3 Gene

Unigene Clusters for ALG3 Gene

ALG3, alpha-1,3- mannosyltransferase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ALG3 Gene

No ASD Table

Relevant External Links for ALG3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ALG3 Gene

mRNA expression in normal human tissues for ALG3 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ALG3 Gene

SOURCE GeneReport for Unigene cluster for ALG3 Gene Hs.478481

genes like me logo Genes that share expressions with ALG3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ALG3 Gene

Orthologs for ALG3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ALG3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ALG3 35
  • 97.1 (n)
  • 96.38 (a)
(Bos Taurus)
Mammalia ALG3 35
  • 92.31 (n)
  • 93.38 (a)
ALG3 36
  • 93 (a)
(Canis familiaris)
Mammalia ALG3 35
  • 92.47 (n)
  • 93.84 (a)
ALG3 36
  • 74 (a)
(Mus musculus)
Mammalia Alg3 35
  • 86.76 (n)
  • 88.81 (a)
Alg3 16
Alg3 36
  • 89 (a)
(Monodelphis domestica)
Mammalia ALG3 36
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia ALG3 36
  • 89 (a)
(Rattus norvegicus)
Mammalia Alg3 35
  • 85.77 (n)
  • 87.67 (a)
(Gallus gallus)
Aves ALG3 35
  • 74.06 (n)
  • 73.4 (a)
ALG3 36
  • 69 (a)
(Anolis carolinensis)
Reptilia ALG3 36
  • 71 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia alg3 35
  • 64.9 (n)
  • 66.51 (a)
(Danio rerio)
Actinopterygii alg3 35
  • 64.04 (n)
  • 66.59 (a)
alg3 36
  • 66 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007168 35
  • 57.95 (n)
  • 53.19 (a)
fruit fly
(Drosophila melanogaster)
Insecta l(2)not 35
  • 59.22 (n)
  • 55.01 (a)
l(2)not 36
  • 41 (a)
(Caenorhabditis elegans)
Secernentea K09E4.2 35
  • 53.96 (n)
  • 51.62 (a)
K09E4.2 36
  • 31 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL299C 35
  • 53.03 (n)
  • 43.05 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ALG3 35
  • 48.39 (n)
  • 38.9 (a)
ALG3 36
  • 33 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E20747g 35
  • 43.19 (n)
  • 36.25 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons ALG3 35
  • 50.33 (n)
  • 47.76 (a)
(Oryza sativa)
Liliopsida Os.16184 35
Os01g0172000 35
  • 51.18 (n)
  • 46.47 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU06552 35
  • 50.73 (n)
  • 41.34 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes alg3 35
  • 42.61 (n)
  • 37.63 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5078 36
  • 55 (a)
Species with no ortholog for ALG3:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ALG3 Gene

Gene Tree for ALG3 (if available)
Gene Tree for ALG3 (if available)

Paralogs for ALG3 Gene Pseudogenes for ALG3 Gene

genes like me logo Genes that share paralogs with ALG3: view

No data available for Paralogs for ALG3 Gene

Variants for ALG3 Gene

Sequence variations from dbSNP and Humsavar for ALG3 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs843331 -- 184,243,392(-) TGAAG(G/T)ATATT intron-variant
rs1687219 -- 184,243,828(-) ACCTC(A/C)CCCTG reference, missense, nc-transcript-variant
rs1709662 -- 184,246,242(+) aatga(G/T)tatac intron-variant
rs2233463 - 184,245,593(-) TGTAC(A/G)TCTTT reference, missense, nc-transcript-variant
rs2233464 -- 184,245,212(-) TGGGG(C/T)TGCTG synonymous-codon, reference, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for ALG3 Gene

Variant ID Type Subtype PubMed ID
nsv829812 CNV Loss 17160897
nsv878057 CNV Loss 21882294
dgv5354n71 CNV Loss 21882294
nsv878060 CNV Loss 21882294
nsv528639 CNV Loss 19592680

Relevant External Links for ALG3 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)
Locus Specific Mutation Databases (LSDB)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ALG3 Gene

Disorders for ALG3 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for ALG3 Gene including...

Search for ALG3 Gene in MalaCards »

(1) OMIM Diseases for ALG3 Gene (608750)


  • Congenital disorder of glycosylation 1D (CDG1D) [MIM:601110]: A multisystem disorder caused by a defect in glycoprotein biosynthesis and characterized by under-glycosylated serum glycoproteins. Congenital disorders of glycosylation result in a wide variety of clinical features, such as defects in the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions. {ECO:0000269 PubMed:10581255, ECO:0000269 PubMed:15840742}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(2) University of Copenhagen DISEASES for ALG3 Gene

(1) Novoseek inferred disease relationships for ALG3 Gene

Disease -log(P) Hits PubMed IDs
congenital disorders 81.7 2

Relevant External Links for ALG3

genes like me logo Genes that share disorders with ALG3: view

Publications for ALG3 Gene

  1. Carbohydrate deficient glycoprotein syndrome type IV: deficiency of dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase. (PMID: 10581255) Koerner C. … von Figura K. (EMBO J. 1999) 3 4 23
  2. An activated 5' cryptic splice site in the human ALG3 gene generates a premature termination codon insensitive to nonsense-mediated mRNA decay in a new case of congenital disorder of glycosylation type Id (CDG-Id). (PMID: 15108280) Denecke J. … Marquardt T. (Hum. Mutat. 2004) 3 23
  3. Will an electric current replace the syringe for anesthesia? (PMID: 1058125) Jerrold L.E. (Dent Stud 1975) 2 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Congenital disorder of glycosylation type Id: clinical phenotype, molecular analysis, prenatal diagnosis, and glycosylation of fetal proteins. (PMID: 16006436) Denecke J. … Marquardt T. (Pediatr. Res. 2005) 3

Products for ALG3 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate ALG3
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for ALG3
    • Block miRNA regulation of ALG3 using miScript Target Protectors

    Sources for ALG3 Gene

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