ALG2 Gene
protein-coding GIFtS: 60
GCID: GC09M101978
|
|
ALG2, alpha-1,3/1,6-mannosyltransferase(Previous names: asparagine-linked glycosylation 2 homolog (yeast, alpha-1,3-mannosyltransferase),...)
| |
Aliases
for ALG2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| Aliases |
|---|
| ALG2, Alpha-1,3/1,6-Mannosyltransferase1 2 | | Asparagine-Linked Glycosylation 2, Alpha-1,3-Mannosyltransferase Homolog (S.Cerevisiae)1 | | CDGIi1 2 | | Alpha-1,3-Mannosyltransferase ALG22 | | NET381 2 | | Alpha-1,3/1,6-Mannosyltransferase ALG22 | | Asparagine-Linked Glycosylation 2 Homolog (Yeast,Alpha-1,3-Mannosyltransferase)1 2 | | Asparagine-Linked Glycosylation 2 Homolog (S. Cerevisiae,Alpha-1,3-Mannosyltransferase)2 | | HALPG21 | | Asparagine-Linked Glycosylation 2, Alpha-1,3-Mannosyltransferase Homolog2 | | Asparagine-Linked Glycosylation Protein 2 Homolog2 3 | | Homolog Of Yeast ALG22 | | GDP-Man:Man(1)GlcNAc(2)-PP-Dol Alpha-1,3-Mannosyltransferase2 3 | | EC 2.4.1.1323 | | GDP-Man:Man(1)GlcNAc(2)-PP-Dolichol Mannosyltransferase2 3 | | EC 2.4.1.2573 | | GDP-Man:Man(2)GlcNAc(2)-PP-Dol Alpha-1,6-Mannosyltransferase2 3 | | CDGII5 | | FLJ145111 | | EC 2.4.18 |
| External Ids: | HGNC: 231591 | Entrez Gene: 853652 | Ensembl: ENSG000001195237 | OMIM: 6079055 | UniProtKB: Q9H5533 |
|---|
| | ORGUL members: | |
|---|
| NONCODE:n407036 | |
Export aliases for ALG2 gene to outside databasesPrevious GC identifers: GC09M095436 GC09M097359 GC09M097358 GC09M099058 GC09M101018 GC09M071577
Summaries
for ALG2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ALG2:
This gene encodes a member of the glycosyltransferase 1 family. The encoded protein acts as an alpha 1,3mannosyltransferase, mannosylating Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate toform Man(3)GlcNAc(2)-dolichol diphosphate. Defects in this gene have been associated with congenital disorder ofglycosylation type Ih (CDG-Ii). Alternative splicing results in multiple transcript variants. (provided by RefSeq, Nov2008)
UniProtKB/Swiss-Prot: ALG2_HUMAN, Q9H553Function: Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to formMan(3)GlcNAc(2)-dolichol diphosphate
Gene Wiki entry for ALG2
|
Genomic Views
for ALG2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_008470.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ALG2 gene promoter:
GR E2F-4 E2F-3a E2F-5 E2F-2 E2F E2F-1 Cart-1 GR-alpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for ALG2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ALG2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9q22.33 Ensembl cytogenetic band: 9q22.33 HGNC cytogenetic band: 9q31.1ALG2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09M101978: view genomic region
(about GC identifiers)
Start:
|
101,978,707 bp from pter |
End:
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101,984,246 bp from pter |
Size:
|
5,540 bases |
Orientation:
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minus strand |
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Proteins
for ALG2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ALG2_HUMAN, Q9H553 (See
protein sequence)Recommended Name: Alpha-1,3/1,6-mannosyltransferase ALG2 Size: 416 amino acids; 47092 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential)
Secondary accessions: A2A2Y0 Q8NBX2 Q8NC39Alternative splicing: 2 isoforms: Q9H553-1 Q9H553-2 Explore the universe of human proteins at neXtProt for ALG2: NX_Q9H553
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H553
4 DME Specific Peptides for ALG2 (Q9H553)
ALG2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_149078.1
ENSEMBL proteins: ENSP00000432675 ENSP00000417764 ENSP00000326609 Reactome Protein details: Q9H553
Human Recombinant Protein Products:
Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8): About this table
ALG2 for ontologies About GeneDecksing
ALG2 Antibody Products:
Assay Products for ALG2: |
Protein
Domains /
Families
for ALG2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ALG2 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9H553ProtoNet protein and cluster: Q9H553 1 Blocks protein family: IPB001296 Glycosyl transferase
UniProtKB/Swiss-Prot: ALG2_HUMAN, Q9H553Similarity: Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily |
Function
for ALG2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ALG2_HUMAN, Q9H553Function: Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to formMan(3)GlcNAc(2)-dolichol diphosphateCatalytic activity: GDP-D-mannose + D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = GDP +D-Man-alpha-(1->3)-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-GlcNAc-diphosphodolicholCatalytic activity: GDP-D-mannose +D-Man-alpha-(1->3)-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = GDP +D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolicholEnzyme Numbers (IUBMB): EC 2.4.12 EC 2.4.1.1321 EC 2.4.1.2571
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ALG2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ALG2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ALG2 (NM_033087) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ALG2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALG2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALG2 |
Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table
ALG2 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for ALG2:
Animal Models:
Mouse knock-out Alg2tm1Lex for ALG2
1 MGI phenotypic allele  for Alg2 (no phenotypes)
ALG2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for ALG2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Asparagine N-linked glycosylation | | | 2 | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein | | | 3 | Metabolism | |
Pathway sources
See GeneCards unified pathways
Show all pathways
4 
Reactome Pathways for ALG2
2 
Kegg Pathways (Kegg details for ALG2):
UniProtKB/Swiss-Prot: ALG2_HUMAN, Q9H553Pathway: Protein modification; protein glycosylation
ALG2 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ALG2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 22)
5/27 Interacting proteins for ALG2 (Q9H5533 ENSP000004177644) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
About this table
Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006488 | dolichol-linked oligosaccharide biosynthetic process |
TAS | -- | | GO:0018279 | protein N-linked glycosylation via asparagine |
TAS | -- | | GO:0033577 | protein glycosylation in endoplasmic reticulum |
IGI | 12684507 | | GO:0043687 | post-translational protein modification |
TAS | -- | | GO:0044267 | cellular protein metabolic process |
TAS | -- |
ALG2 for ontologies About GeneDecksing
|
Drugs & Compounds
for ALG2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ALG2
3 HMDB Compounds for ALG2 About this table
Search CenterWatch for drugs/clinical trials and news about ALG2
|
Transcripts
for ALG2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ALG2 gene (2 alternative transcripts): NM_033087.3 NM_197973.2 Unigene Cluster for ALG2: Asparagine-linked glycosylation 2, alpha-1,3-mannosyltransferase homolog (S. cerevisiae) Hs.40919 [show with all ESTs]Unigene Representative Sequence: NR_0245323 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000238477(uc004azg.3 uc004azf.3) ENST00000476832 ENST00000319033
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ALG2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ALG2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ALG2 (NM_033087) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ALG2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALG2 |
Additional cDNA sequence: AB161356.1 AK027417.1 AK074704.1 AK075172.1 AK075189.1 AY358697.1 BC015126.1 BC017876.1 NR_024532.1 10 DOTS entries: DT.100026389 DT.443496 DT.101975871 DT.99961425 DT.121209348 DT.95376062 DT.97840885 DT.121209371 DT.121209384 DT.95376063 24/201 AceView cDNA sequences (see all 201): BG617202 AI913655 NM_197973 AI863884 AI696801 AI739663 AI299594 BX280093 AI374867 BG054806 CN479455 CK903766 CD368005 BQ641538 AI222699 CA950203 BM982936 AI686368 AA426161 BG697908 BM687809 CF132606 AI769222 BF435010
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for ALG2 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c |
|---|
|
| SP1: | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | |
| SP3: | | | | | - | | - | | | | | | | |
ECgene alternative splicing isoforms for ALG2
|
Expression
for ALG2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ALG2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTCAGCAGAG
About this image
See ALG2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ALG2
SOURCE GeneReport for Unigene cluster: Hs.40919
SABiosciences Custom PCR Arrays for ALG2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ALG2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ALG2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ALG2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ALG2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALG2 |
Orthologs
for ALG2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for ALG2 gene from 9/31 species (see all 31) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Alg21 , 5 |
asparagine-linked glycosylation 2 homolog (yeast, alpha-1,3-mannosyltransferase)5
asparagine-linked glycosylation 2 (alpha-1,3-mannosyltransferase)1 |
82.49(n)1
80.72(a)1 |
|
4 (26.03 cM)5
567371 NM_019998.31 NP_064382.31
474650675 |
chicken
(Gallus gallus) |
Aves |
ALG21 |
asparagine-linked glycosylation 2, alpha-1,3-mannosyltransferase more |
70.86(n)
72.19(a) |
|
420998 XM_003640790.1 XP_003640838.1 |
lizard
(Anolis carolinensis) |
Reptilia |
ALG26 |
-- |
66(a) |
1 ↔ 1 |
6(55626830-55631389) |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.186202 |
Danio rerio, Similar to hypothetical protein FLJ14511, more |
75.19(n) |
|
BC049444.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG12911 |
CG1291 |
55.86(n)
53.42(a) |
|
38374 NM_139515.4 NP_647772.1 |
worm
(Caenorhabditis elegans) |
Secernentea |
F09E5.21 |
Protein F09E5.2 |
51.4(n)
48.09(a) |
|
173912 NM_062609.4 NP_495010.2 |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
ALG21 |
Alg2p |
49.1(n)
43.99(a) |
|
852815 NP_011450.1 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT1G788001 |
alpha-1,3/alpha-1,6-mannosyltransferase |
51.82(n)
50.38(a) |
|
844216 NM_106527.3 NP_178001.2 |
rice
(Oryza sativa) |
Liliopsida |
Os04g05896001 |
hypothetical protein |
52.49(n)
50.13(a) |
|
4336813 NM_001060234.1 NP_001053699.1 |
ENSEMBL Gene Tree for ALG2 (if available)
TreeFam Gene Tree for ALG2 (if available) |
Paralogs
for ALG2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for ALG2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ALG2 (101978707 - 101984246 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ALG2: --
Human Gene Mutation Database (HGMD): ALG2
Locus Specific Mutation Databases (LSDB): ALG2
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ALG2 |
|
Disorders
/ Diseases
for ALG2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ALG2 for disorders About GeneDecksing
OMIM gene information: 607905
OMIM disorders: 607906
UniProtKB/Swiss-Prot: ALG2_HUMAN, Q9H553
Defects in ALG2 are the cause of congenital disorder of glycosylation type 1I (CDG1I) [MIM:607906]. CDGs are afamily of severe inherited diseases caused by a defect in protein N-glycosylation. They are characterized byunder-glycosylated serum proteins. These multisystem disorders present with a wide variety of clinical features, suchas disorders of the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulationdisorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins duringembryonic development, differentiation, and maintenance of cell functions
6  diseases for ALG2: About MalaCardscongenital disorder of glycosylation congenital disorder of glycosylation type ii congenital disorder of glycosylation type 1i cutis laxa
coloboma hypotonia
2 diseases from the University of Copenhagen DISEASES database for ALG2:Congenital myasthenic syndrome Coloboma GeneTests: ALG2
Congenital Disorders of Glycosylation
Export disorders for ALG2 gene to outside databases
|
Publications
for ALG2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ALG2 gene, integrated from 9 sources (see all 39):
(articles sorted by number of sources associating them with ALG2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A new type of congenital disorders of glycosylation (CDG-Ii) provides new insights into the early steps of dolichol-linked oligosaccharide biosynthesis. (PubMed id 12684507)1, 2, 3 Thiel C.... Koerner C. (2003)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- The apoptosis linked gene ALG-2 is dysregulated in tumors of various origin and contributes to cancer cell viability. (PubMed id 19383317)1, 9 la Cour J.M....Berchtold M.W. (2008)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Molecular basis for defect in Alix-binding by alterna tively spliced isoform of ALG-2 (ALG-2DeltaGF122) and structural roles of F122 in target recognition. (PubMed id 20691033)1 Inuzuka T....Maki M. (2010)
- Simultaneous targeting of Requiem & Alg-2 in Chin ese hamster ovary cells for improved recombinant protein production. (PubMed id 20571937)1 Lim Y....Wong D.C. (2010)
|
External Searches for ALG2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ALG2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ALG2 gene
(According to HUGE)
About This Section
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Specialized Databases showing ALG2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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| Name | Description |
| PharmGKB entry for ALG2 | Pharmacogenomics, SNPs, Pathways | | GeneReviews | http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/ALG2 | | GGDB | http://riodb.ibase.aist.go.jp/rcmg/ggdb/ |
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About This Section
| Patent Information for ALG2 gene:
Search GeneIP for patents involving ALG2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for ALG2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | OriGene Antibodies for ALG2 | | OriGene shRNA RFP for ALG2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ALG2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ALG2 | | | OriGene Protein Over-expression Lysate for ALG2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ALG2 | | OriGene 3'-UTR Clone for ALG2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ALG2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ALG2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for ALG2 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ALG2 | | OriGene Custom Protein Services for ALG2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ALG2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ALG2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ALG2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ALG2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ALG2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ALG2 |
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| | | | Search Tocris compounds for ALG2 |
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 | | | ALG2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALG2 |
|  |  |  | | | | Search ThermoFisher Antibodies for ALG2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALG2 |
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Last full update: 18 Mar 2013 -
Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013
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