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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ALG1L2 Gene

pseudogene   GIFtS: 32
GCID: GC03P129800

ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase-like...

(Previous name: asparagine-linked glycosylation 1-like 2 )
  Search for ALG1L2
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Biological research products
for ALG1L2    

Aliases
for ALG1L2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
ALG1, Chitobiosyldiphosphodolichol Beta-Mannosyltransferase-Like 21 2
Asparagine-Linked Glycosylation 1-Like 21 2
Putative Glycosyltransferase ALG1L22
EC 2.4.1.-3

External Ids:    HGNC: 372581   Entrez Gene: 6449742   Ensembl: ENSG000002512877   UniProtKB: C9J2023   

Export aliases for ALG1L2 gene to outside databases

Previous GC identifers: GC03P131284 GC03P127184


Summaries
for ALG1L2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: AG1L2_HUMAN, C9J202
Function: Putative glycosyltransferase (By similarity)




Genomic Views
for ALG1L2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_005612.16  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for ALG1L2
         Other transcription factors

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Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ALG1L2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q22.1   Ensembl cytogenetic band:  3q22.1   HGNC cytogenetic band: 3q22.1

ALG1L2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ALG1L2 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P129800:  view genomic region     (about GC identifiers)

Start:
 129,800,674 bp from pter      End:
 129,832,070 bp from pter
Size:
 31,397 bases      Orientation:
 plus strand

Proteins
for ALG1L2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: AG1L2_HUMAN, C9J202 (See protein sequence)
Recommended Name: Putative glycosyltransferase ALG1L2  
Size: 215 amino acids; 24154 Da

Explore the universe of human proteins at neXtProt for ALG1L2: NX_C9J202

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_C9J202

    • ALG1L2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001129624.1  
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    Protein Domains /
    Families
    for ALG1L2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ALG1L2 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR026051 ALG1-like

    Graphical View of Domain Structure for InterPro Entry C9J202

    ProtoNet protein and cluster: C9J202

    UniProtKB/Swiss-Prot: AG1L2_HUMAN, C9J202
    Similarity: Belongs to the glycosyltransferase group 1 family


    Function
    for ALG1L2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: AG1L2_HUMAN, C9J202
    Function: Putative glycosyltransferase (By similarity)

    Enzyme Number (IUBMB): EC 2.4.1.-1

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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016757transferase activity, transferring glycosyl groups IEA--


    ALG1L2 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for ALG1L2:
     Decreased POU5F1-GFP protein e 


    Pathways & Interactions
    for ALG1L2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ALG1L2

    Drugs & Compounds
    for ALG1L2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ALG1L2
    Search CenterWatch for drugs/clinical trials and news about ALG1L2 

    Transcripts
    for ALG1L2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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    About This Section
    REFSEQ mRNAs for ALG1L2 gene: 
    NM_001136152.1  

    Unigene Cluster for ALG1L2:

    Asparagine-linked glycosylation 1-like 2
    Hs.722197  [show with all ESTs]
    Unigene Representative Sequence: NM_001136152
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000503500 ENST00000507643 ENST00000506370 ENST00000511726 ENST00000425059(uc011bld.2 uc010hth.3)


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    1 DOTS entry:

    DT.95277932 

    GeneLoc Exon Structure


    Expression
    for ALG1L2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ALG1L2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAGAAAACCG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ALG1L2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Definitive endoderm-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ALG1L2 Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.722197
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    In Situ
    Assay Products:     
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    Orthologs
    for ALG1L2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    		   --

    ENSEMBL Gene Tree for ALG1L2 (if available)
    TreeFam Gene Tree for ALG1L2 (if available) 

    Paralogs
    for ALG1L2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for ALG1L2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/880 NCBI SNPs in ALG1L2 are shown (see all 880)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 3 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1887196041,2
    		--129798739(+) CAGATC/TGGTTG 1 -- us2k10--------
    rs1159276701,2
    		--129798740(+) AGATCG/TGTTGA 1 -- us2k11Minor allele frequency- T:0.01NA 120
    rs284543181,2
    		C,--129798780(+) GACTCA/GGTGGA 1 -- us2k16Minor allele frequency- G:0.42NA WA 246
    rs285829911,2
    		C,--129798865(+) CCTTTA/GTATTT 1 -- us2k15Minor allele frequency- G:0.32NA WA 126
    rs1133978601,2
    		C--129798885(+) ACAGGA/TGGCTG 1 -- us2k10--------
    rs1180592861,2
    		--129799024(+) CCGAAT/AGGACC 1 -- us2k11Minor allele frequency- A:0.01EA 120
    rs1405708611,2
    		--129799042(+) CCACAA/CTTTCT 1 -- us2k10--------
    rs1470836121,2
    		--129799074(+) ATTCAC/TTCCCC 1 -- us2k10--------
    rs1913957101,2
    		--129799080(+) TCCCCC/TTCATC 1 -- us2k10--------
    rs1132006431,2
    		C--129799098(+) TGCTGA/GCGGTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ALG1L2 (129800674 - 129832070 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 18 variations for ALG1L2
         15/18 CNVs (see all 18): 37603 91539 63588 91542 1060 91541 2472 98445 36062 3448 62099 91543 36060 36061 38102

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    Disorders / Diseases
    for ALG1L2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		   --

    Publications
    for ALG1L2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ALG1L2 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ALG1L2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (2006)
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    External Searches for ALG1L2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ALG1L2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 644974 HGNC: 37258 Ensembl:ENSG00000251287 euGenes: HUgn644974 ECgene: ALG1L2
    H-InvDB: ALG1L2

    Other Databases showing ALG1L2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ALG1L2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ALG1L2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ALG1L2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ALG1L2 gene:
    Search GeneIP for patents involving ALG1L2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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