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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ALG1L Gene

protein-coding   GIFtS: 35
GCID: GC03M125648

ALG1, Chitobiosyldiphosphodolichol Beta-Mannosyltransferase-Like

(Previous name: asparagine-linked glycosylation 1-like)
  Search for ALG1L
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
ALG1, Chitobiosyldiphosphodolichol Beta-Mannosyltransferase-Like1 2     beta-1,4-mannosyltransferase-like2
Asparagine-Linked Glycosylation 1-Like 11 2     Putative Glycosyltransferase ALG1-Like2
Asparagine-Linked Glycosylation 1-Like1     EC 2.4.1.-3
ALG1L12     

External Ids:    HGNC: 337211   Entrez Gene: 2008102   Ensembl: ENSG000001893667   UniProtKB: Q6GMV13   

Export aliases for ALG1L gene to outside databases

Previous GC identifers: GC03M127131 GC03M123028


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ALG1L Gene: 
ALG1L (ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase-like) is a protein-coding gene. GO annotations related to this gene include transferase activity, transferring glycosyl groups. An important paralog of this gene is ALG1.

UniProtKB/Swiss-Prot: ALG1L_HUMAN, Q6GMV1
Function: Putative glycosyltransferase (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_005612.16  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ALG1L gene promoter:
         AhR   AP-1   p53   COMP1   STAT5A   POU3F2   Arnt   Evi-1   
         Other transcription factors

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Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ALG1L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q21.2   Ensembl cytogenetic band:  3q21.2   HGNC cytogenetic band: 3q21.2

ALG1L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ALG1L gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M125648:  view genomic region     (about GC identifiers)

Start:
125,648,118 bp from pter      End:
125,655,887 bp from pter
Size:
7,770 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ALG1L_HUMAN, Q6GMV1 (See protein sequence)
Recommended Name: Putative glycosyltransferase ALG1-like  
Size: 187 amino acids; 21132 Da
Secondary accessions: D3DNA5

Explore the universe of human proteins at neXtProt for ALG1L: NX_Q6GMV1

Explore proteomics data for ALG1L at MOPED 

ALG1L Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

ALG1L Protein Expression

REFSEQ proteins (2 alternative transcripts): 
NP_001015050.2  NP_001182152.1  

ENSEMBL proteins: 
 ENSP00000340009  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
GLT1: Glycosyltransferase group 1 domain containing

1 InterPro protein domain:
 IPR026051 ALG1-like

Graphical View of Domain Structure for InterPro Entry Q6GMV1

ProtoNet protein and cluster: Q6GMV1

UniProtKB/Swiss-Prot: ALG1L_HUMAN, Q6GMV1
Similarity: Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 33 subfamily


ALG1L for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: ALG1L_HUMAN, Q6GMV1
Function: Putative glycosyltransferase (By similarity)

     Enzyme Number (IUBMB): EC 2.4.1.-1

     Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016757transferase activity, transferring glycosyl groups IEA--
     
ALG1L for ontologies           About GeneDecksing


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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ALG1L

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
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Browse Tocris compounds for ALG1L

Search CenterWatch for drugs/clinical trials and news about ALG1L

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ALG1L gene (2 alternative transcripts): 
NM_001015050.2  NM_001195223.1  

Unigene Cluster for ALG1L:

ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase-like
Hs.591299  [show with all ESTs]
Unigene Representative Sequence: BX382902
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000340333(uc021xdh.1 uc003eig.2)
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Additional mRNA sequence: BC073816.1 

4 DOTS entries:

DT.86850597  DT.100728792  DT.100651818  DT.95277941 

21 AceView cDNA sequences:

BM016759 AA024843 BE735854 BF515842 BC073816 BI199296 BU161457 BX382902 
BI198396 BI085096 BM017116 AA478734 CD685738 AA493371 AI688521 BG896917 
BI198436 CD697213 CD708577 AI688358 CD699831 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ALG1L expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AAGAAAATGG
ALG1L Expression
About this image


See ALG1L Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.591299
    SABiosciences Custom PCR Arrays for ALG1L
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals and fungi.

Orthologs for ALG1L gene from 6/11 species (see all 11)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chicken
(Gallus gallus)
Aves ALG16
Uncharacterized protein
24(a)
1 → many
14(13379012-13387157)
lizard
(Anolis carolinensis)
Reptilia --
--
23(a)
1 → many
GL343612.1(276151-295023)
zebrafish
(Danio rerio)
Actinopterygii alg16
asparagine-linked glycosylation 1 homolog (yeast, ...
21(a)
1 → many
3(29011402-29020759)
fruit fly
(Drosophila melanogaster)
Insecta CG180126
--
18(a)
1 → many
3R(13635123-13636848)
worm
(Caenorhabditis elegans)
Secernentea T26A5.46
Protein T26A5.4
12(a)
1 → many
III(6460118-6462222)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ALG16
Mannosyltransferase, involved in asparagine-linked...
13(a)
1 → many
II(458872-460221)
        Species with no ortholog for ALG1L

ENSEMBL Gene Tree for ALG1L (if available)
TreeFam Gene Tree for ALG1L (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for ALG1L gene
ALG12  
2 SIMAP similar genes for ALG1L using alignment to 1 protein entry:     ALG1L_HUMAN:
ALG1    ALG1L2

ALG1L for paralogs           About GeneDecksing


5/10 Pseudogenes.org Pseudogenes for ALG1L (see all 10)
PGOHUM00000242556 PGOHUM00000242773 PGOHUM00000239646 PGOHUM00000238073 PGOHUM00000258160


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/274 SNPs in ALG1L are shown (see all 274)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 3 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
VAR_0399624
----see VAR_0399622 N D mis40--------
VAR_0399634
----see VAR_0399632 I T mis40--------
VAR_0399644
----see VAR_0399642 G S mis40--------
rs76159521,2
C,F,A,H--125649403(+) ACCTGC/AAGAGC 4 /L syn119Minor allele frequency- A:0.24NS EA NA CSA WA EU 5851
rs1482632441,2
C,F--125649439(+) ACCAGG/TCCATT 4 G syn12Minor allele frequency- T:0.01NA EU 4699
rs117063761,2
C,F,H--125649485(+) GAGAAC/TCAAGG 2 -- int13Minor allele frequency- T:0.04NA EU 1310
rs76183991,2
C,F,A--125649499(+) CCTGAG/CAGCTG 2 -- int14Minor allele frequency- C:0.50NA CSA 6
rs558285721,2
C--125649518(+) AGACAA/CCAGAC 2 -- int10--------
rs76299771,2
C,F,A--125649573(+) GCCAGT/GCTGGG 2 -- int18Minor allele frequency- G:0.27WA NA CSA EA 367
rs76183351,2
C,A--125649621(+) TTAGAT/CTTGGC 2 -- int13Minor allele frequency- C:0.00NA CSA 5

HapMap Linkage Disequilibrium report for ALG1L (125648118 - 125655887 bp)

Structural Variations
     Database of Genomic Variants (DGV) 4 variations for ALG1L:    About this table     
Variant IDTypeSubtypePubMed ID
nsv877410CNV Loss21882294
dgv5238n71CNV Gain21882294
nsv829716CNV Gain+Loss17160897
dgv1491e1CNV Complex17122850

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ALG1L for disorders           About MalaCards

ALG1L for disorders           About GeneDecksing

Genetic Association Database (GAD): ALG1L

Export disorders for ALG1L gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for ALG1L gene integrated from 9 sources:
(articles sorted by number of sources associating them with ALG1L)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (2011)
  2. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (2006)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 200810 HGNC: 33721 AceView: LOC200810 Ensembl:ENSG00000189366 euGenes: HUgn200810
ECgene: ALG1L H-InvDB: ALG1L

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for ALG1L Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for ALG1L gene:
Search GeneIP for patents involving ALG1L

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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transforming growth factor, beta 1
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