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Aliases for ALG1L Gene

Aliases for ALG1L Gene

  • ALG1, Chitobiosyldiphosphodolichol Beta-Mannosyltransferase Like 2 3
  • Asparagine-Linked Glycosylation 1-Like 1 2 3
  • ALG1, Chitobiosyldiphosphodolichol Beta-Mannosyltransferase-Like 5
  • Asparagine-Linked Glycosylation 1-Like 2
  • Putative Glycosyltransferase ALG1-Like 3
  • Beta-1,4-Mannosyltransferase-Like 3
  • EC 2.4.1.- 4
  • ALG1L1 3

External Ids for ALG1L Gene

Previous GeneCards Identifiers for ALG1L Gene

  • GC03M127131
  • GC03M125648
  • GC03M123028

Summaries for ALG1L Gene

GeneCards Summary for ALG1L Gene

ALG1L (ALG1, Chitobiosyldiphosphodolichol Beta-Mannosyltransferase Like) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring glycosyl groups and mannosyltransferase activity. An important paralog of this gene is ALG1.

UniProtKB/Swiss-Prot for ALG1L Gene

  • Putative glycosyltransferase.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ALG1L Gene

Genomics for ALG1L Gene

Regulatory Elements for ALG1L Gene

Enhancers for ALG1L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around ALG1L on UCSC Golden Path with GeneCards custom track

Genomic Location for ALG1L Gene

Chromosome:
3
Start:
125,928,840 bp from pter
End:
125,952,098 bp from pter
Size:
23,259 bases
Orientation:
Minus strand

Genomic View for ALG1L Gene

Genes around ALG1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ALG1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ALG1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ALG1L Gene

Proteins for ALG1L Gene

  • Protein details for ALG1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6GMV1-ALG1L_HUMAN
    Recommended name:
    Putative glycosyltransferase ALG1-like
    Protein Accession:
    Q6GMV1
    Secondary Accessions:
    • D3DNA5

    Protein attributes for ALG1L Gene

    Size:
    187 amino acids
    Molecular mass:
    21132 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ALG1L Gene

Post-translational modifications for ALG1L Gene

No Post-translational modifications

Other Protein References for ALG1L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ALG1L Gene

Domains & Families for ALG1L Gene

Gene Families for ALG1L Gene

Protein Domains for ALG1L Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ALG1L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6GMV1

UniProtKB/Swiss-Prot:

ALG1L_HUMAN :
  • Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 33 subfamily.
Family:
  • Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 33 subfamily.
genes like me logo Genes that share domains with ALG1L: view

Function for ALG1L Gene

Molecular function for ALG1L Gene

UniProtKB/Swiss-Prot Function:
Putative glycosyltransferase.

Enzyme Numbers (IUBMB) for ALG1L Gene

Gene Ontology (GO) - Molecular Function for ALG1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000030 mannosyltransferase activity IBA --
genes like me logo Genes that share ontologies with ALG1L: view
genes like me logo Genes that share phenotypes with ALG1L: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ALG1L Gene

Localization for ALG1L Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ALG1L Gene COMPARTMENTS Subcellular localization image for ALG1L gene
Compartment Confidence
endoplasmic reticulum 3
cytosol 2
extracellular 2
nucleus 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for ALG1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IBA --
genes like me logo Genes that share ontologies with ALG1L: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ALG1L Gene

Pathways & Interactions for ALG1L Gene

SuperPathways for ALG1L Gene

No Data Available

Interacting Proteins for ALG1L Gene

Gene Ontology (GO) - Biological Process for ALG1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006486 protein glycosylation IBA --
GO:0097502 mannosylation IEA --
genes like me logo Genes that share ontologies with ALG1L: view

No data available for Pathways by source and SIGNOR curated interactions for ALG1L Gene

Drugs & Compounds for ALG1L Gene

No Compound Related Data Available

Transcripts for ALG1L Gene

mRNA/cDNA for ALG1L Gene

Unigene Clusters for ALG1L Gene

ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ALG1L Gene

No ASD Table

Relevant External Links for ALG1L Gene

GeneLoc Exon Structure for
ALG1L
ECgene alternative splicing isoforms for
ALG1L

Expression for ALG1L Gene

mRNA expression in normal human tissues for ALG1L Gene

mRNA differential expression in normal tissues according to GTEx for ALG1L Gene

This gene is overexpressed in Bladder (x6.1).

NURSA nuclear receptor signaling pathways regulating expression of ALG1L Gene:

ALG1L

SOURCE GeneReport for Unigene cluster for ALG1L Gene:

Hs.591299
genes like me logo Genes that share expression patterns with ALG1L: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for ALG1L Gene

Orthologs for ALG1L Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ALG1L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ALG1L 34
  • 97.58 (n)
  • 95.65 (a)
ALG1L 35
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ALG1 35
  • 27 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 28 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 25 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Alg1 35
  • 26 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 35
  • 23 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 23 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii alg1 35
  • 21 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG18012 35
  • 18 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea T26A5.4 35
  • 13 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ALG1 35
  • 13 (a)
OneToMany
Species where no ortholog for ALG1L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ALG1L Gene

ENSEMBL:
Gene Tree for ALG1L (if available)
TreeFam:
Gene Tree for ALG1L (if available)

Paralogs for ALG1L Gene

Paralogs for ALG1L Gene

(2) SIMAP similar genes for ALG1L Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ALG1L: view

Variants for ALG1L Gene

Sequence variations from dbSNP and Humsavar for ALG1L Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
VAR_039962 -
VAR_039963 -
VAR_039964 -
rs2333431 -- 125,946,613(+) GTGCT(A/G)TAGCC intron-variant
rs2333432 -- 125,946,654(+) GGGAG(C/T)CTCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ALG1L Gene

Variant ID Type Subtype PubMed ID
esv2759174 CNV loss 17122850
nsv1011457 CNV gain 25217958
nsv1160975 CNV duplication 26073780
nsv591465 CNV gain 21841781
nsv829716 CNV gain+loss 17160897
nsv967058 CNV duplication 23825009

Variation tolerance for ALG1L Gene

Residual Variation Intolerance Score: 91.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.11; 90.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ALG1L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ALG1L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ALG1L Gene

Disorders for ALG1L Gene

Relevant External Links for ALG1L

Genetic Association Database (GAD)
ALG1L
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ALG1L

No disorders were found for ALG1L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ALG1L Gene

Publications for ALG1L Gene

  1. Gene-smoking interactions identify several novel blood pressure loci in the Framingham Heart Study. (PMID: 25189868) Sung Y.J. … Rao D.C. (Am. J. Hypertens. 2015) 3 65
  2. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny D.M. … Gibbs R.A. (Nature 2006) 4 65
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 65
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 65

Products for ALG1L Gene

Sources for ALG1L Gene

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