ALG1L Gene
protein-coding GIFtS: 34
GCID: GC03M125648
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ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase-like(Previous name: asparagine-linked glycosylation 1-like )
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Aliases
for ALG1L gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| ALG1, Chitobiosyldiphosphodolichol Beta-Mannosyltransferase-Like1 2 | | Beta-1,4-Mannosyltransferase-Like1 | | ALG1L11 2 | | Putative Glycosyltransferase ALG1-Like2 | | Asparagine-Linked Glycosylation 1-Like1 | | EC 2.4.1.-3 | | Asparagine-Linked Glycosylation 1-Like 12 | | |
Export aliases for ALG1L gene to outside databasesPrevious GC identifers: GC03M127131 GC03M123028 |
Summaries
for ALG1L gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ALG1L_HUMAN, Q6GMV1Function: Putative glycosyltransferase (By similarity)
|
Genomic Views
for ALG1L gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_005612.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ALG1L gene promoter:
AhR AP-1 p53 COMP1 STAT5A POU3F2 Arnt Evi-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for ALG1L
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ALG1L |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q21.2 Ensembl cytogenetic band: 3q21.2 HGNC cytogenetic band: 3q21.2ALG1L Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03M125648: view genomic region
(about GC identifiers)
Start:
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125,648,118 bp from pter |
End:
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125,655,882 bp from pter |
Size:
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7,765 bases |
Orientation:
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minus strand |
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Proteins
for ALG1L gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ALG1L_HUMAN, Q6GMV1 (See
protein sequence)Recommended Name: Putative glycosyltransferase ALG1-like Size: 187 amino acids; 21132 Da
Secondary accessions: D3DNA5Explore the universe of human proteins at neXtProt for ALG1L: NX_Q6GMV1
ALG1L Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001015050.2 NP_001182152.1
ENSEMBL proteins: ENSP00000340009
Human Recombinant Protein Products for ALG1L:
ALG1L Antibody Products:
Assay Products for ALG1L: |
Protein
Domains /
Families
for ALG1L gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ALG1L for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q6GMV1ProtoNet protein and cluster: Q6GMV1 UniProtKB/Swiss-Prot: ALG1L_HUMAN, Q6GMV1Similarity: Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 33 subfamily |
Function
for ALG1L gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: ALG1L_HUMAN, Q6GMV1Function: Putative glycosyltransferase (By similarity) Enzyme Number (IUBMB): EC 2.4.1.-1
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016757 | transferase activity, transferring glycosyl groups |
IEA | -- |
ALG1L for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ALG1L (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ALG1L
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Synthesis Service for ALG1L | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALG1L |
|
Pathways & Interactions
for ALG1L gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ALG1L
|
Drugs & Compounds
for ALG1L gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ALG1L
Search CenterWatch for drugs/clinical trials and news about ALG1L
|
Transcripts
for ALG1L gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ALG1L gene (2 alternative transcripts): NM_001015050.2 NM_001195223.1 Unigene Cluster for ALG1L: Asparagine-linked glycosylation 1-like Hs.591299 [show with all ESTs]Unigene Representative Sequence: BX3829021 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000340333(uc021xdh.1 uc003eig.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ALG1L (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ALG1L
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): ALG1L (NM_001195223) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ALG1L | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALG1L |
Additional cDNA sequence: BC073816.1 4 DOTS entries: DT.86850597 DT.100728792 DT.100651818 DT.95277941 21 AceView cDNA sequences: BI085096 BI199296 BX382902 AA024843 BE735854 BF515842 BU161457 BM017116 BI198396 BM016759 BC073816 AI688521 AA478734 CD685738 AA493371 BI198436 BG896917 CD697213 CD708577 AI688358 CD699831
GeneLoc Exon Structure
|
Expression
for ALG1L gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ALG1L expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAGAAAATGG
About this image
See ALG1L Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.591299
SABiosciences Custom PCR Arrays for ALG1L
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ALG1L
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat ALG1L | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ALG1L | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ALG1L |
Orthologs
for ALG1L gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for ALG1L gene from 7/20 species (see all 20) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
ALG16 |
Uncharacterized protein |
24(a) |
1 → many |
14(14140340-14148508) |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
23(a) |
1 → many |
GL343612.1(278612-294430) |
zebrafish
(Danio rerio) |
Actinopterygii |
alg16 |
asparagine-linked glycosylation 1 homolog (yeast, ... |
21(a) |
1 → many |
3(29011402-29020759) |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG180126 |
-- |
18(a) |
possible ortholog |
3R(13635123-13636848) |
worm
(Caenorhabditis elegans) |
Secernentea |
T26A5.46 |
Protein T26A5.4 |
12(a) |
1 → many |
III(6460066-6462170) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT1G165706 |
beta-1,4-mannosyltransferase |
14(a) |
1 → many |
1(5670577-5673600) |
rice
(Oryza sativa) |
Liliopsida |
---- |
glycosyl transferase, group 1 domain containing pr...glycosyl transferase, group 1 domain containing pr... |
14(a)14(a) |
many ↔ manymany ↔ many |
3(4222432-4227470) 6(21734128-21738841) |
Species with no ortholog for ALG1L
ENSEMBL Gene Tree for ALG1L (if available)
TreeFam Gene Tree for ALG1L (if available) |
Paralogs
for ALG1L gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ALG1L gene
- ALG12
2 SIMAP similar genes for ALG1L using alignment to 1 protein entry: ALG1L_HUMAN:ALG1 ALG1L2
ALG1L for paralogs About GeneDecksing
5/10 Pseudogenes.org Pseudogenes for ALG1L (see all 10)
PGOHUM00000242556 PGOHUM00000242773 PGOHUM00000239646 PGOHUM00000238073 PGOHUM00000258160
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Genomic Variants
for ALG1L gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ALG1L (125648118 - 125655882 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for ALG1L
2 CNVs: 4352 3446 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ALG1L |
|
Disorders
/ Diseases
for ALG1L gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for ALG1L gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ALG1L gene integrated from 9 sources:
(articles sorted by number of sources associating them with ALG1L) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for ALG1L gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ALG1L gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ALG1L gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ALG1L gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ALG1L | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ALG1L gene:
Search GeneIP for patents involving ALG1L
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ALG1L gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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