Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ALG14 Gene

Aliases for ALG14 Gene

  • ALG14, UDP-N-Acetylglucosaminyltransferase Subunit 2 3
  • Asparagine-Linked Glycosylation 14 Homolog (S. Cerevisiae) 2
  • Asparagine-Linked Glycosylation 14 Homolog (Yeast) 2

External Ids for ALG14 Gene

Previous GeneCards Identifiers for ALG14 Gene

  • GC01M095161
  • GC01M095449
  • GC01M093570

Summaries for ALG14 Gene

Entrez Gene Summary for ALG14 Gene

  • This gene is a member of the glycosyltransferase 1 family. The encoded protein and ALG13 are thought to be subunits of UDP-GlcNAc transferase, which catalyzes the first two committed steps in endoplasmic reticulum N-linked glycosylation. Mutations in this gene have been linked to congenital myasthenic syndrome (CMSWTA). Alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2015]

UniProtKB/Swiss-Prot for ALG14 Gene

  • May be involved in protein N-glycosylation. May play a role in the second step of the dolichol-linked oligosaccharide pathway. May anchor the catalytic subunit ALG13 to the ER.

Gene Wiki entry for ALG14 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ALG14 Gene

Genomics for ALG14 Gene

Regulatory Elements for ALG14 Gene

Genomic Location for ALG14 Gene

Start:
94,974,407 bp from pter
End:
95,072,956 bp from pter
Size:
98,550 bases
Orientation:
Minus strand

Genomic View for ALG14 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ALG14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ALG14 Gene

Proteins for ALG14 Gene

  • Protein details for ALG14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96F25-ALG14_HUMAN
    Recommended name:
    UDP-N-acetylglucosamine transferase subunit ALG14 homolog
    Protein Accession:
    Q96F25
    Secondary Accessions:
    • A8K030

    Protein attributes for ALG14 Gene

    Size:
    216 amino acids
    Molecular mass:
    24151 Da
    Quaternary structure:
    • Heterodimer with ALG13 isoform 2 to form a functional enzyme.

neXtProt entry for ALG14 Gene

Proteomics data for ALG14 Gene at MOPED

Post-translational modifications for ALG14 Gene

  • Ubiquitination at Lys99
  • Modification sites at PhosphoSitePlus

Other Protein References for ALG14 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ALG14 Gene

Domains for ALG14 Gene

Protein Domains for ALG14 Gene

Suggested Antigen Peptide Sequences for ALG14 Gene

Graphical View of Domain Structure for InterPro Entry

Q96F25

UniProtKB/Swiss-Prot:

ALG14_HUMAN :
  • Q96F25
Family:
  • Belongs to the ALG14 family.
genes like me logo Genes that share domains with ALG14: view

No data available for Gene Families for ALG14 Gene

Function for ALG14 Gene

Molecular function for ALG14 Gene

UniProtKB/Swiss-Prot Function: May be involved in protein N-glycosylation. May play a role in the second step of the dolichol-linked oligosaccharide pathway. May anchor the catalytic subunit ALG13 to the ER.

Phenotypes for ALG14 Gene

GenomeRNAi human phenotypes for ALG14:
genes like me logo Genes that share phenotypes with ALG14: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ALG14

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ALG14 Gene

Localization for ALG14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ALG14 Gene

Endoplasmic reticulum membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ALG14 Gene COMPARTMENTS Subcellular localization image for ALG14 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ALG14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ALG14: view

Pathways for ALG14 Gene

genes like me logo Genes that share pathways with ALG14: view

Interacting Proteins for ALG14 Gene

Gene Ontology (GO) - Biological Process for ALG14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006488 dolichol-linked oligosaccharide biosynthetic process TAS --
GO:0018279 protein N-linked glycosylation via asparagine TAS --
GO:0043687 post-translational protein modification TAS --
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with ALG14: view

Compounds for ALG14 Gene

(4) HMDB Compounds for ALG14 Gene

Compound Synonyms Cas Number PubMed IDs
N,N'-Diacetylchitobiosyldiphosphodolichol
  • Chitobiosyldiphosphodolichol
Not Available
N-Acetyl-D-glucosaminyldiphosphodolichol
  • N-Acetyl-D-glucosaminyl-diphosphodolichol
Not Available
Uridine 5'-diphosphate
  • 5'-UDP
58-98-0
Uridine diphosphate-N-acetylglucosamine
  • N-[2-[[[5-[(2,4-dioxo-1H-pyrimidin-1-yl)]-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphinoyl]oxy-hydroxy-phosphinoyl]oxy-4,5-dihydroxy-6-(hydroxymethyl)tetrahydropyran-3-yl]acetamide
528-04-1
genes like me logo Genes that share compounds with ALG14: view

Transcripts for ALG14 Gene

mRNA/cDNA for ALG14 Gene

Unigene Clusters for ALG14 Gene

ALG14, UDP-N-acetylglucosaminyltransferase subunit:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ALG14

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ALG14 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1: -
SP2: - - -
SP3:

Relevant External Links for ALG14 Gene

GeneLoc Exon Structure for
ALG14
ECgene alternative splicing isoforms for
ALG14

Expression for ALG14 Gene

mRNA expression in normal human tissues for ALG14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ALG14 Gene

SOURCE GeneReport for Unigene cluster for ALG14 Gene Hs.408927

genes like me logo Genes that share expressions with ALG14: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ALG14 Gene

Orthologs for ALG14 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ALG14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ALG14 35
  • 98.3 (n)
  • 97.67 (a)
ALG14 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ALG14 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ALG14 35
  • 89.53 (n)
  • 89.53 (a)
ALG14 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Alg14 35
  • 81.33 (n)
  • 79.5 (a)
Alg14 16
Alg14 36
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ALG14 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ALG14 36
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Alg14 35
  • 81.33 (n)
  • 80.09 (a)
chicken
(Gallus gallus)
Aves ALG14 35
  • 74.01 (n)
  • 72.88 (a)
ALG14 36
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ALG14 36
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia alg14 35
  • 67.69 (n)
  • 67.86 (a)
zebrafish
(Danio rerio)
Actinopterygii alg14 35
  • 62.93 (n)
  • 63.78 (a)
alg14 36
  • 58 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003461 35
  • 52.15 (n)
  • 49.08 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6308 35
  • 48.21 (n)
  • 47.62 (a)
CG6308 36
  • 40 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea hpo-16 36
  • 31 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ALG14 36
  • 30 (a)
OneToOne
ALG14 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G18230 35
  • 52.05 (n)
  • 47.59 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes alg14 35
  • 51.3 (n)
  • 49.7 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 50 (a)
OneToOne
Species with no ortholog for ALG14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ALG14 Gene

ENSEMBL:
Gene Tree for ALG14 (if available)
TreeFam:
Gene Tree for ALG14 (if available)

Paralogs for ALG14 Gene

No data available for Paralogs for ALG14 Gene

Variants for ALG14 Gene

Sequence variations from dbSNP and Humsavar for ALG14 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1122028 -- 94,994,712(+) GCTGA(C/G)GCCTG intron-variant
rs1342888 -- 95,015,624(-) AAACC(C/T)GCCCC intron-variant
rs1418775 -- 95,008,692(-) GTTAA(A/G)AGGGT intron-variant
rs1557176 -- 94,986,521(+) aggct(A/G)tagtg intron-variant
rs1557177 -- 94,986,531(+) gcagt(A/G)gcacg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ALG14 Gene

Variant ID Type Subtype PubMed ID
nsv830636 CNV Loss 17160897
esv993631 CNV Insertion 20482838
esv1116942 CNV Insertion 17803354
esv5799 CNV Loss 19470904
esv2670670 CNV Deletion 23128226
nsv498675 CNV Loss 21111241
dgv57n67 CNV Loss 20364138
nsv513994 CNV Loss 21397061

Relevant External Links for ALG14 Gene

HapMap Linkage Disequilibrium report
ALG14
Human Gene Mutation Database (HGMD)
ALG14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ALG14 Gene

Disorders for ALG14 Gene

(1) University of Copenhagen DISEASES for ALG14 Gene

Relevant External Links for ALG14

Genetic Association Database (GAD)
ALG14
genes like me logo Genes that share disorders with ALG14: view

No data available for UniProtKB/Swiss-Prot for ALG14 Gene

Publications for ALG14 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Two proteins homologous to the N- and C-terminal domains of the bacterial glycosyltransferase Murg are required for the second step of dolichyl-linked oligosaccharide synthesis in Saccharomyces cerevisiae. (PMID: 15615718) Chantret I. … Moore S.E. (J. Biol. Chem. 2005) 2 3
  3. Alg14 recruits Alg13 to the cytoplasmic face of the endoplasmic reticulum to form a novel bipartite UDP-N-acetylglucosamine transferase required for the second step of N-linked glycosylation. (PMID: 16100110) Gao X.-D. … Dean N. (J. Biol. Chem. 2005) 3 4
  4. Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations. (PMID: 22359512) Demirkan A. … Schmitz G. (PLoS Genet. 2012) 3 48
  5. Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. (PMID: 23362303) Wu J.H. … Mozaffarian D. (Circ Cardiovasc Genet 2013) 3

Products for ALG14 Gene

Sources for ALG14 Gene

Back to Top

Content