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Aliases for ALG11 Gene

Aliases for ALG11 Gene

  • ALG11, Alpha-1,2-Mannosyltransferase 2 3 5
  • GDP-Man:Man(3)GlcNAc(2)-PP-Dolichol Alpha-1,2-Mannosyltransferase 2 3
  • Asparagine-Linked Glycosylation Protein 11 Homolog 3 4
  • Glycolipid 2-Alpha-Mannosyltransferase 3 4
  • GT8 3 4
  • Asparagine-Linked Glycosylation 11 Homolog (S. Cerevisiae, Alpha-1,2-Mannosyltransferase) 2
  • Asparagine-Linked Glycosylation 11, Alpha-1,2-Mannosyltransferase Homolog (Yeast) 2
  • Asparagine-Linked Glycosylation 11, Alpha-1,2-Mannosyltransferase Homolog 3
  • EC 2.4.1.131 4
  • EC 2.4.1 63
  • CDG1P 3

External Ids for ALG11 Gene

Previous GeneCards Identifiers for ALG11 Gene

  • GC13P051485
  • GC13P052587
  • GC13P033375

Summaries for ALG11 Gene

Entrez Gene Summary for ALG11 Gene

  • This gene encodes a GDP-Man:Man3GlcNAc2-PP-dolichol-alpha1,2-mannosyltransferase which is localized to the cytosolic side of the endoplasmic reticulum (ER) and catalyzes the transfer of the fourth and fifth mannose residue from GDP-mannose (GDP-Man) to Man3GlcNAc2-PP-dolichol and Man4GlcNAc2-PP-dolichol resulting in the production of Man5GlcNAc2-PP-dolichol. Mutations in this gene are associated with congenital disorder of glycosylation type Ip (CDGIP). This gene overlaps but is distinct from the UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast) gene. A pseudogene of the GDP-Man:Man3GlcNAc2-PP-dolichol-alpha1,2-mannosyltransferase has been identified on chromosome 19. [provided by RefSeq, Aug 2010]

GeneCards Summary for ALG11 Gene

ALG11 (ALG11, Alpha-1,2-Mannosyltransferase) is a Protein Coding gene. Diseases associated with ALG11 include congenital disorder of glycosylation, type ip. Among its related pathways are Metabolism and Transport to the Golgi and subsequent modification. GO annotations related to this gene include GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity.

UniProtKB/Swiss-Prot for ALG11 Gene

  • Mannosyltransferase involved in the last steps of the synthesis of Man5GlcNAc(2)-PP-dolichol core oligosaccharide on the cytoplasmic face of the endoplasmic reticulum. Catalyzes the addition of the 4th and 5th mannose residues to the dolichol-linked oligosaccharide chain.

Gene Wiki entry for ALG11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ALG11 Gene

Genomics for ALG11 Gene

Regulatory Elements for ALG11 Gene

Promoters for ALG11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ALG11 on UCSC Golden Path with GeneCards custom track

Genomic Location for ALG11 Gene

Chromosome:
13
Start:
52,012,387 bp from pter
End:
52,029,664 bp from pter
Size:
17,278 bases
Orientation:
Plus strand

Genomic View for ALG11 Gene

Genes around ALG11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ALG11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ALG11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ALG11 Gene

Proteins for ALG11 Gene

  • Protein details for ALG11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2TAA5-ALG11_HUMAN
    Recommended name:
    GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase
    Protein Accession:
    Q2TAA5
    Secondary Accessions:
    • A5PLP3
    • B4DKW9
    • Q5TAN9
    • Q6DKI6
    • Q96FI7

    Protein attributes for ALG11 Gene

    Size:
    492 amino acids
    Molecular mass:
    55651 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI11023.1; Type=Frameshift; Positions=16; Evidence={ECO:0000305};

neXtProt entry for ALG11 Gene

Proteomics data for ALG11 Gene at MOPED

Selected DME Specific Peptides for ALG11 Gene

Post-translational modifications for ALG11 Gene

  • Glycosylation at Asn 257 and Asn 273
  • Modification sites at PhosphoSitePlus

Other Protein References for ALG11 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for ALG11 Gene

Gene Families for ALG11 Gene

Protein Domains for ALG11 Gene

Suggested Antigen Peptide Sequences for ALG11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q2TAA5

UniProtKB/Swiss-Prot:

ALG11_HUMAN :
  • Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.
Family:
  • Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.
genes like me logo Genes that share domains with ALG11: view

Function for ALG11 Gene

Molecular function for ALG11 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
2 GDP-alpha-D-mannose + D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = 2 GDP + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol.
UniProtKB/Swiss-Prot Function:
Mannosyltransferase involved in the last steps of the synthesis of Man5GlcNAc(2)-PP-dolichol core oligosaccharide on the cytoplasmic face of the endoplasmic reticulum. Catalyzes the addition of the 4th and 5th mannose residues to the dolichol-linked oligosaccharide chain.

Enzyme Numbers (IUBMB) for ALG11 Gene

Phenotypes for ALG11 Gene

genes like me logo Genes that share phenotypes with ALG11: view

Human Phenotype Ontology for ALG11 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

  • Taconic Biosciences Mouse Models for ALG11

No data available for Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ALG11 Gene

Localization for ALG11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ALG11 Gene

Endoplasmic reticulum. Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ALG11 Gene COMPARTMENTS Subcellular localization image for ALG11 gene
Compartment Confidence
endoplasmic reticulum 3

Gene Ontology (GO) - Cellular Components for ALG11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with ALG11: view

Pathways & Interactions for ALG11 Gene

genes like me logo Genes that share pathways with ALG11: view

Gene Ontology (GO) - Biological Process for ALG11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006488 dolichol-linked oligosaccharide biosynthetic process TAS --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with ALG11: view

No data available for SIGNOR curated interactions for ALG11 Gene

Drugs & Compounds for ALG11 Gene

(1) Drugs for ALG11 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0

(1) Additional Compounds for ALG11 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Guanosine diphosphate mannose
  • GDP Mannose
  • GDP-D-Mannose
  • GDP-Glucose
  • GDP-Mannose
  • Guanosine Diphosphate Mannose
3123-67-9
genes like me logo Genes that share compounds with ALG11: view

Transcripts for ALG11 Gene

Unigene Clusters for ALG11 Gene

ALG11, alpha-1,2-mannosyltransferase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ALG11 Gene

No ASD Table

Relevant External Links for ALG11 Gene

GeneLoc Exon Structure for
ALG11
ECgene alternative splicing isoforms for
ALG11

Expression for ALG11 Gene

mRNA expression in normal human tissues for ALG11 Gene

Protein differential expression in normal tissues from HIPED for ALG11 Gene

This gene is overexpressed in Nasal epithelium (49.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ALG11 Gene



SOURCE GeneReport for Unigene cluster for ALG11 Gene Hs.512963

genes like me logo Genes that share expression patterns with ALG11: view

Protein tissue co-expression partners for ALG11 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ALG11 Gene

Orthologs for ALG11 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ALG11 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ALG11 35
  • 88.28 (n)
  • 89.63 (a)
ALG11 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ALG11 35
  • 89.84 (n)
  • 90.04 (a)
ALG11 36
  • 66 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Alg11 35
  • 85.95 (n)
  • 86.35 (a)
Alg11 16
Alg11 36
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Alg11 35
  • 85.68 (n)
  • 86.97 (a)
oppossum
(Monodelphis domestica)
Mammalia ALG11 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ALG11 36
  • 77 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ALG11 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves ALG11 35
  • 72.93 (n)
  • 73.06 (a)
ALG11 36
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ALG11 36
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia alg11 35
  • 67.64 (n)
  • 69.37 (a)
zebrafish
(Danio rerio)
Actinopterygii alg11 35
  • 63.2 (n)
  • 65.49 (a)
alg11 36
  • 63 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011324 35
  • 52.26 (n)
  • 51.83 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11306 35
  • 54.22 (n)
  • 51.29 (a)
CG11306 36
  • 49 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea B0361.8 35
  • 52.14 (n)
  • 46.85 (a)
B0361.8 36
  • 44 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL235W 35
  • 46.81 (n)
  • 39.47 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F03817g 35
  • 49.92 (n)
  • 39.95 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ALG11 35
  • 53.09 (n)
  • 42.38 (a)
ALG11 36
  • 32 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons LEW3 35
  • 52.97 (n)
  • 46.95 (a)
rice
(Oryza sativa)
Liliopsida Os12g0583000 35
  • 52.56 (n)
  • 46.15 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU06779 35
  • 49.64 (n)
  • 46.75 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes alg11 35
  • 51.99 (n)
  • 44.92 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 51 (a)
OneToOne
Species with no ortholog for ALG11:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ALG11 Gene

ENSEMBL:
Gene Tree for ALG11 (if available)
TreeFam:
Gene Tree for ALG11 (if available)

Paralogs for ALG11 Gene

Pseudogenes.org Pseudogenes for ALG11 Gene

genes like me logo Genes that share paralogs with ALG11: view

No data available for Paralogs for ALG11 Gene

Variants for ALG11 Gene

Sequence variations from dbSNP and Humsavar for ALG11 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
VAR_055902 -
VAR_064908 Congenital disorder of glycosylation 1P (CDG1P)
VAR_068070 Congenital disorder of glycosylation 1P (CDG1P)
VAR_068071 Congenital disorder of glycosylation 1P (CDG1P)
VAR_068072 Congenital disorder of glycosylation 1P (CDG1P)

Structural Variations from Database of Genomic Variants (DGV) for ALG11 Gene

Variant ID Type Subtype PubMed ID
nsv900082 CNV Gain 21882294

Variation tolerance for ALG11 Gene

Residual Variation Intolerance Score: 30.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.35; 41.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ALG11 Gene

HapMap Linkage Disequilibrium report
ALG11
Human Gene Mutation Database (HGMD)
ALG11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ALG11 Gene

Disorders for ALG11 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ALG11 Gene - From: OMIM, ClinVar, Swiss-Prot, and GeneCards

Disorder Aliases PubMed IDs
congenital disorder of glycosylation, type ip
  • congenital disorder of glycosylation 1p
- elite association - COSMIC cancer census association via MalaCards
Search ALG11 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

ALG11_HUMAN
  • Congenital disorder of glycosylation 1P (CDG1P) [MIM:613661]: A multisystem disorder caused by a defect in glycoprotein biosynthesis and characterized by under-glycosylated serum glycoproteins. Congenital disorders of glycosylation result in a wide variety of clinical features, such as defects in the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions. {ECO:0000269 PubMed:20080937, ECO:0000269 PubMed:22213132}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for ALG11

Genetic Association Database (GAD)
ALG11
Human Genome Epidemiology (HuGE) Navigator
ALG11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ALG11
genes like me logo Genes that share disorders with ALG11: view

No data available for Genatlas for ALG11 Gene

Publications for ALG11 Gene

  1. A severe human metabolic disease caused by deficiency of the endoplasmatic mannosyltransferase hALG11 leads to congenital disorder of glycosylation-Ip. (PMID: 20080937) Rind N. … Korner C. (Hum. Mol. Genet. 2010) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Cloning and transcriptional expression of mouse mannosyltransferase IV/V cDNA, which is involved in the synthesis of lipid-linked oligosaccharides. (PMID: 25036826) Nishimura Y. … Nishikawa Y. (Biosci. Biotechnol. Biochem. 2014) 3
  4. Improved diagnostics lead to identification of three new patients with congenital disorder of glycosylation-Ip. (PMID: 22213132) Thiel C. … Korner C. (Hum. Mutat. 2012) 3
  5. Defining the membrane proteome of NK cells. (PMID: 19946888) Ghosh D. … Wilkins J.A. (J Mass Spectrom 2010) 3

Products for ALG11 Gene

Sources for ALG11 Gene

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