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ALG10B Gene

protein-coding   GIFtS: 56
GCID: GC12P038710

ALG10B, Alpha-1,2-Glucosyltransferase

(Previous names: asparagine-linked glycosylation 10, alpha-1,2-glucosyltransferase...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ALG10B, Alpha-1,2-Glucosyltransferase1 2     Asparagine-Linked Glycosylation 10 Homolog B (Yeast,
Alpha-1,2-Glucosyltransferase)2
Potassium Channel Regulator 11 2 3     Asparagine-Linked Glycosylation 10, Alpha-1,2-Glucosyltransferase Homolog
B2
Alpha-1,2-Glucosyltransferase ALG10-A2 3     Dolichyl-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dolichol Alpha-1,2-
Glucosyltransferase2
Alpha-2-Glucosyltransferase ALG10-B2 3     Modifier Of The HERG Potassium Channel2
Asparagine-Linked Glycosylation Protein 10 Homolog B2 3     Putative Alpha-1,2-Glucosyltransferase ALG10-B2
KCR12 3     Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol
Alpha-1,2-Glucosyltransferase2
2- Glucosyltransferase1     EC 2.4.1.2563
Asparagine-Linked Glycosylation 10, Alpha-1,2-Glucosyltransferase Homolog
B (Yeast)1
     EC 2.4.18
Dolichyl-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dolichol Alpha-11     EC 2.4.1.168
ALG102     

External Ids:    HGNC: 310881   Entrez Gene: 1442452   Ensembl: ENSG000001755487   UniProtKB: Q5I7T13   

Export aliases for ALG10B gene to outside databases

Previous GC identifers: GC12U900492 GC12P036998 GC12P035735


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ALG10B Gene:
ALG10B (ALG10B, alpha-1,2-glucosyltransferase) is a protein-coding gene. Diseases associated with ALG10B include drug-induced liver injury due to flucloxacillin, and long qt syndrome. GO annotations related to this gene include transferase activity, transferring hexosyl groups. An important paralog of this gene is ALG10.

UniProtKB/Swiss-Prot: AG10B_HUMAN, Q5I7T1
Function: Putative alpha-1,2-glucosyltransferase, which adds the third glucose residue to the lipid-linked
oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose
(Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol. When coupled to KCNH2 may reduce
KCNH2 sensitivity to classic proarrhythmic drug blockade, possibly by mediating glycosylation of KCNH2




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ALG10B gene promoter:
         LHX3b/Lhx3b   AML1a   Evi-1   SRY   FAC1   POU2F1   POU2F1a   Pax-4a   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidALG10B promoter sequence
   Search Chromatin IP Primers for ALG10B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ALG10B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q12   Ensembl cytogenetic band:  12q12   HGNC cytogenetic band: 12q12

ALG10B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ALG10B gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P038710:  view genomic region     (about GC identifiers)

Start:
38,710,380 bp from pter      End:
38,723,528 bp from pter
Size:
13,149 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: AG10B_HUMAN, Q5I7T1 (See protein sequence)
Recommended Name: Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase  
Size: 473 amino acids; 55448 Da
Subunit: Interacts with KCNH1 and KCNH2 (By similarity)
Caution: PubMed:15280551 reports a Val-447 variant, however there is evidence that the right variant is Val-446
Secondary accessions: B2RPF4

Explore the universe of human proteins at neXtProt for ALG10B: NX_Q5I7T1

Explore proteomics data for ALG10B at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys224
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for ALG10B (Q5I7T1)
     FSVGNFY  LADNRHY 


    See ALG10B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001013642.1  
    ENSEMBL proteins: 
     ENSP00000310120   ENSP00000448819   ENSP00000449210  
    Reactome Protein details: Q5I7T1

    ALG10B Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR016900 Alg10

    Graphical View of Domain Structure for InterPro Entry Q5I7T1

    ProtoNet protein and cluster: Q5I7T1

    UniProtKB/Swiss-Prot: AG10B_HUMAN, Q5I7T1
    Similarity: Belongs to the ALG10 glucosyltransferase family


    ALG10B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AG10B_HUMAN, Q5I7T1
    Function: Putative alpha-1,2-glucosyltransferase, which adds the third glucose residue to the lipid-linked
    oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose
    (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol. When coupled to KCNH2 may reduce
    KCNH2 sensitivity to classic proarrhythmic drug blockade, possibly by mediating glycosylation of KCNH2
    Catalytic activity: Dolichyl beta-D-glucosyl phosphate +
    D-Glc-alpha-(1->3)-D-Glc-alpha-(1->3)-D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->2)-D-Man-alpha-(1->6))-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol
    =
    D-Glc-alpha-(1->2)-D-Glc-alpha-(1->3)-D-Glc-alpha-(1->3)-D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->2)-D-Man-alpha-(1->6))-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol
    + dolichyl phosphate

         Enzyme Numbers (IUBMB): EC 2.4.12 EC 2.4.1.2561 EC 2.4.1.162

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016758transferase activity, transferring hexosyl groups IEA--
         
    ALG10B for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ALG10B:
     Synthetic lethal with imatinib 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ALG10B
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    miRNA
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    miRTarBase miRNAs that target ALG10B:
    hsa-mir-192-5p (MIRT026560), hsa-mir-26a-5p (MIRT050088)

    Block miRNA regulation of human, mouse, rat ALG10B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ALG10B (see all 22):
    hsa-miR-607 hsa-miR-485-3p hsa-miR-132 hsa-miR-9 hsa-miR-2115 hsa-miR-548x hsa-miR-205* hsa-miR-3121-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    AG10B_HUMAN, Q5I7T1: Cell membrane; Multi-pass membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    endoplasmic reticulum1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016021integral component of membrane IEA--

    ALG10B for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ALG10B About    
    See pathways by source

    SuperPathContained pathways About
    1Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Asparagine N-linked glycosylation0.49
    Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein0.38
    N-Glycan biosynthesis0.49
    Metabolism of proteins0.30
    Post-translational protein modification0.43
    2Metabolism
    Metabolic pathways0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ALG10B
        Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein


    2 Kegg Pathways  (Kegg details for ALG10B):
        N-Glycan biosynthesis
    Metabolic pathways

    UniProtKB/Swiss-Prot: AG10B_HUMAN, Q5I7T1
    Pathway: Protein modification; protein glycosylation


    ALG10B for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ALG10B
    Interactions:

        Search GeneGlobe Interaction Network for ALG10B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    Selected Interacting proteins for ALG10B (Q5I7T13 ENSP000003101204) via UniProtKB, MINT, STRING, and/or I2D (see all 42)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    KCNH2Q128093, ENSP000002621864I2D: score=2 STRING: ENSP00000262186
    ALG12Q9BV103, ENSP000003338134I2D: score=1 STRING: ENSP00000333813
    ALG3Q926853, ENSP000003807934I2D: score=1 STRING: ENSP00000380793
    ALG5Q9Y6733, ENSP000002398914I2D: score=1 STRING: ENSP00000239891
    ALG6Q9Y6723, ENSP000003601494I2D: score=1 STRING: ENSP00000360149
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006488dolichol-linked oligosaccharide biosynthetic process TAS--
    GO:0018279protein N-linked glycosylation via asparagine TAS--
    GO:0043687post-translational protein modification TAS--
    GO:0044267cellular protein metabolic process TAS--

    ALG10B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ALG10B (AG10B)

    1 HMDB Compound for ALG10B    About this table
    CompoundSynonyms CAS #PubMed Ids
    Dolichyl b-D-glucosyl phosphateDolichol monophosphate glucose (see all 10)220496-27-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ALG10B gene: 
    NM_001013620.3  

    Unigene Cluster for ALG10B:

    ALG10B, alpha-1,2-glucosyltransferase
    Hs.259305  [show with all ESTs]
    Unigene Representative Sequence: NM_001013620
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000308742(uc001rln.4) ENST00000551464 ENST00000553138 ENST00000548240

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ALG10B (see all 22):
    hsa-miR-607 hsa-miR-485-3p hsa-miR-132 hsa-miR-9 hsa-miR-2115 hsa-miR-548x hsa-miR-205* hsa-miR-3121-3p
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    Additional mRNA sequence: 

    AK123102.1 AK307955.1 AY845858.1 BC137413.1 BC137414.1 BC144617.1 

    7 DOTS entries:

    DT.95231180  DT.121140383  DT.433165  DT.100687048  DT.95364811  DT.40120334  DT.100839086 

    8 AceView cDNA sequences:

    CR622214 AL712776 CD252003 BX401727 BX494049 BE242781 BM149103 BE154665 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ALG10B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTGATAATA
    ALG10B Expression
    About this image

    ALG10B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ALG10B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.259305

    UniProtKB/Swiss-Prot: AG10B_HUMAN, Q5I7T1
    Tissue specificity: Highly expressed in heart, placenta, liver, kidney and pancreas. Weakly expressed in lung,
    skeletal muscle and brain

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ALG10B gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves ALG106
    Gallus gallus asparagine-linked glycosylation 10, ...
    68(a)
    1 → many
    1(15491430-15497448)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    69(a)
    1 → many
    5(99328812-99340301)
    zebrafish
    (Danio rerio)
    Actinopterygii alg106
    asparagine-linked glycosylation 10
    55(a)
    1 → many
    4(27685063-27690743) ENSDARG00000053917
    fruit fly
    (Drosophila melanogaster)
    Insecta Alg106
    Alpha 3 glucosyltransferase
    33(a)
    1 → many
    3L(11158071-11159720)
    worm
    (Caenorhabditis elegans)
    Secernentea tag-1791 tag-179 47.8(n)
    37.91(a)
      172855  NM_060233.2  NP_492634.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes DIE2(YGR227W)4 Dolichyl-phosphoglucose-dependent alpha-1,2 glucosyltransferase more   --   7(947420-948997) 853142  NP_011743.1 
            Species with no ortholog for ALG10B

    ENSEMBL Gene Tree for ALG10B (if available)
    TreeFam Gene Tree for ALG10B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ALG10B gene
    ALG102  
    1 SIMAP similar gene for ALG10B using alignment to 4 protein entries:     AG10B_HUMAN (see all proteins):
    ALG10

    ALG10B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    AG10B_HUMAN, Q5I7T1: Genetic variations in ALG10B may reduce susceptibility to acquired long QT syndrome


    Selected SNPs for ALG10B (see all 408)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs740878081,2
    C,F--38708584(+) GAATCT/CAGTTT 1 -- us2k12Minor allele frequency- C:0.17WA 120
    rs1816760951,2
    --38708641(+) CGAACA/TTTTTT 1 -- us2k10--------
    rs18438741,2
    C,F,H--38708937(-) TTTAGA/GATGGC 1 -- us2k118Minor allele frequency- G:0.02NS EA NA WA CSA 910
    rs1465893381,2
    --38708949(+) CCCTAC/TATTTC 1 -- us2k10--------
    rs1863814881,2
    C--38709066(+) TAAATA/GTCTAG 1 -- us2k10--------
    rs1151710821,2
    C,F--38709098(+) AACGGC/TCCACT 1 -- us2k11Minor allele frequency- T:0.07WA 118
    rs1908580631,2
    --38709303(+) GCTAAA/GCATCA 1 -- us2k10--------
    rs1412767601,2
    C--38709552(+) TATATG/TCCTGC 1 -- us2k10--------
    rs1130480981,2
    C,F--38709557(+) GCCTGT/CCAAAG 1 -- us2k11Minor allele frequency- C:0.00CSA 1
    rs18438711,2
    C--38709598(-) TTGTAG/AAAAAA 1 -- us2k11Minor allele frequency- A:0.00NA 2

    HapMap Linkage Disequilibrium report for ALG10B (38710380 - 38723528 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ALG10B (see all 21):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2745769CNV Deletion23290073
    esv2362578CNV Deletion18987734
    esv2422349CNV Duplication17116639
    esv2422488CNV Duplication17116639
    nsv8963CNV Loss18304495
    nsv899004CNV Gain21882294
    esv2751097CNV Gain17911159
    nsv898971CNV Gain21882294
    dgv1410n71CNV Gain21882294
    dgv196n27CNV Gain19166990

    Human Gene Mutation Database (HGMD): ALG10B
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ALG10B
    DNA2.0 Custom Variant and Variant Library Synthesis for ALG10B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    2 diseases for ALG10B:    
    About MalaCards
    drug-induced liver injury due to flucloxacillin    long qt syndrome

    1 disease from the University of Copenhagen DISEASES database for ALG10B:
    Long QT syndrome

    ALG10B for disorders           About GeneDecksing

    Genetic Association Database (GAD): ALG10B

    Export disorders for ALG10B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ALG10B gene, integrated from 10 sources (see all 12):
    (articles sorted by number of sources associating them with ALG10B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. In vivo identification of genes that modify ether-a-go-go-related gene activity in Caenorhabditis elegans may also affect human cardiac arrhythmia. (PubMed id 15280551)1, 2, 9 Petersen C.I.... Balser J.R. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    2. HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin. (PubMed id 19483685)1, 4 Daly A.K.... . (Nat. Genet. 2009)
    3. The IKr drug response is modulated by KCR1 in transfected cardiac and noncardiac cell lines. (PubMed id 14525949)1, 2 Kupershmidt S.... Balser J.R. (FASEB J. 2003)
    4. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    5. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    6. A KCR1 variant implicated in susceptibility to the long QT syndrome. (PubMed id 20950623)1 Hayashi K....Yamagishi M. (J. Mol. Cell. Cardiol. 2011)
    7. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    8. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)2 Scherer S.E.... Gibbs R.A. (Nature 2006)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 144245 HGNC: 31088 AceView: LOC144245 Ensembl:ENSG00000175548 euGenes: HUgn144245
    ECgene: ALG10B Kegg: 144245 H-InvDB: ALG10B

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ALG10B Pharmacogenomics, SNPs, Pathways
    GGDBhttp://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=ALG10B

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ALG10B gene:
    Search GeneIP for patents involving ALG10B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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