Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ALG10B Gene

protein-coding   GIFtS: 55
GCID: GC12P038710

ALG10B, Alpha-1,2-Glucosyltransferase

(Previous names: asparagine-linked glycosylation 10, alpha-1,2-glucosyltransferase...)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
ALG10B, Alpha-1,2-Glucosyltransferase1 2     Asparagine-Linked Glycosylation 10 Homolog B (Yeast,
Alpha-1,2-Glucosyltransferase)2
Potassium Channel Regulator 11 2 3     Asparagine-Linked Glycosylation 10, Alpha-1,2-Glucosyltransferase Homolog
B2
Alpha-1,2-Glucosyltransferase ALG10-A2 3     Dolichyl-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dolichol Alpha-1,2-
Glucosyltransferase2
Alpha-2-Glucosyltransferase ALG10-B2 3     Modifier Of The HERG Potassium Channel2
Asparagine-Linked Glycosylation Protein 10 Homolog B2 3     Putative Alpha-1,2-Glucosyltransferase ALG10-B2
KCR12 3     Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol
Alpha-1,2-Glucosyltransferase2
2- Glucosyltransferase1     EC 2.4.1.2563
Asparagine-Linked Glycosylation 10, Alpha-1,2-Glucosyltransferase Homolog
B (Yeast)1
     EC 2.4.18
Dolichyl-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dolichol Alpha-11     EC 2.4.1.168
ALG102     

External Ids:    HGNC: 310881   Entrez Gene: 1442452   Ensembl: ENSG000001755487   UniProtKB: Q5I7T13   

Export aliases for ALG10B gene to outside databases

Previous GC identifers: GC12U900492 GC12P036998 GC12P035735


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ALG10B Gene: 
ALG10B (ALG10B, alpha-1,2-glucosyltransferase) is a protein-coding gene. Diseases associated with ALG10B include long qt syndrome, and among its related super-pathways are WNT ligand biogenesis and trafficking and Signaling by GPCR. GO annotations related to this gene include transferase activity, transferring hexosyl groups. An important paralog of this gene is ALG10.

UniProtKB/Swiss-Prot: AG10B_HUMAN, Q5I7T1
Function: Putative alpha-1,2-glucosyltransferase, which adds the third glucose residue to the lipid-linked
oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose
(Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol. When coupled to KCNH2 may reduce
KCNH2 sensitivity to classic proarrhythmic drug blockade, possibly by mediating glycosylation of KCNH2




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_029419.12  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ALG10B gene promoter:
         LHX3b/Lhx3b   AML1a   Evi-1   SRY   FAC1   POU2F1   POU2F1a   Pax-4a   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidALG10B promoter sequence
   Search SABiosciences Chromatin IP Primers for ALG10B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ALG10B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q12   Ensembl cytogenetic band:  12q12   HGNC cytogenetic band: 12q12

ALG10B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ALG10B gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P038710:  view genomic region     (about GC identifiers)

Start:
38,710,380 bp from pter      End:
38,723,528 bp from pter
Size:
13,149 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: AG10B_HUMAN, Q5I7T1 (See protein sequence)
Recommended Name: Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase  
Size: 473 amino acids; 55448 Da
Subunit: Interacts with KCNH1 and KCNH2 (By similarity)
Subcellular location: Cell membrane; Multi-pass membrane protein (By similarity)
Caution: PubMed:15280551 reports a Val-447 variant, however there is evidence that the right variant is Val-446
Secondary accessions: B2RPF4

Explore the universe of human proteins at neXtProt for ALG10B: NX_Q5I7T1

Explore proteomics data for ALG10B at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q5I7T1

  • 2 DME Specific Peptides for ALG10B (Q5I7T1)
     FSVGNFY  LADNRHY 

    ALG10B Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ALG10B Protein Expression
    REFSEQ proteins: NP_001013642.1  
    ENSEMBL proteins: 
     ENSP00000310120   ENSP00000448819   ENSP00000449210  
    Reactome Protein details: Q5I7T1
    Human Recombinant Protein Products for ALG10B: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for ALG10B
    GenScript Custom Purified and Recombinant Proteins Services for ALG10B
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ALG10B 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016021integral to membrane IEA--

    ALG10B for ontologies           About GeneDecksing



    ALG10B Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for ALG10B
    GenScript Custom Superior Antibodies Services for ALG10B
    Abcam antibodies for ALG10B
    Cloud-Clone Corp. Antibodies for ALG10B 
    ThermoFisher Antibodies for ALG10B
    LSBio Antibodies in human, mouse, rat for ALG10B 

    Assay Products for ALG10B: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ALG10B
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ALG10B
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ALG10B 
    Cloud-Clone Corp. CLIAs for ALG10B


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR016900 Alpha1_2_glucosyltferase_Alg10
     IPR007006 Glycosyltransferase_ALG10

    Graphical View of Domain Structure for InterPro Entry Q5I7T1

    ProtoNet protein and cluster: Q5I7T1

    UniProtKB/Swiss-Prot: AG10B_HUMAN, Q5I7T1
    Similarity: Belongs to the ALG10 glucosyltransferase family


    ALG10B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AG10B_HUMAN, Q5I7T1
    Function: Putative alpha-1,2-glucosyltransferase, which adds the third glucose residue to the lipid-linked
    oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose
    (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol. When coupled to KCNH2 may reduce
    KCNH2 sensitivity to classic proarrhythmic drug blockade, possibly by mediating glycosylation of KCNH2
    Catalytic activity: Dolichyl beta-D-glucosyl phosphate +
    D-Glc-alpha-(1->3)-D-Glc-alpha-(1->3)-D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->2)-D-Man-alpha-(1->6))-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol
    =
    D-Glc-alpha-(1->2)-D-Glc-alpha-(1->3)-D-Glc-alpha-(1->3)-D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->2)-D-Man-alpha-(1->6))-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol
    + dolichyl phosphate

         Enzyme Numbers (IUBMB): EC 2.4.12 EC 2.4.1.2561 EC 2.4.1.162

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016758transferase activity, transferring hexosyl groups IEA--
         
    ALG10B for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ALG10B:
     Synthetic lethal with imatinib 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ALG10B 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ALG10B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ALG10B 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ALG10B 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ALG10B
    8/22 QIAGEN miScript miRNA Assays for microRNAs that regulate ALG10B (see all 22):
    hsa-miR-607 hsa-miR-485-3p hsa-miR-132 hsa-miR-9 hsa-miR-2115 hsa-miR-548x hsa-miR-205* hsa-miR-3121-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ALG10B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ALG10B

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ALG10B
    Sirion Biotech Customized adenovirus for overexpression of ALG10B

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for ALG10B (see all 5)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ALG10B (NM_001013620)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ALG10B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALG10B
    Sirion Biotech Customized lentivirus for stable overexpression of ALG10B 
                         Customized lentivirus expression plasmids for stable overexpression of ALG10B 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ALG10B
    Search LifeMap BioReagents cell lines for ALG10B
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALG10B


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ALG10B About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Asparagine N-linked glycosylation
    Asparagine N-linked glycosylation0.77
    N-Glycan biosynthesis0.52
    WNT ligand biogenesis and trafficking0.77
    Post-translational protein modification0.44
    Signaling by Wnt0.62
    Metabolism of proteins0.35
    2Signaling by GPCR
    Signal Transduction0.55
    3Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein0.53
    4Metabolism
    Metabolic pathways0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5/7        Reactome Pathways for ALG10B (see all 7)
        Signaling by Wnt
    Asparagine N-linked glycosylation
    Signal Transduction
    Metabolism of proteins
    Post-translational protein modification


    2         Kegg Pathways  (Kegg details for ALG10B):
        N-Glycan biosynthesis
    Metabolic pathways

    UniProtKB/Swiss-Prot: AG10B_HUMAN, Q5I7T1
    Pathway: Protein modification; protein glycosylation


    ALG10B for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ALG10B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/37 Interacting proteins for ALG10B (Q5I7T13 ENSP000003101204) via UniProtKB, MINT, STRING, and/or I2D (see all 37)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    KCNH2Q128093, ENSP000002621864I2D: score=2 STRING: ENSP00000262186
    ALG12Q9BV103, ENSP000003338134I2D: score=1 STRING: ENSP00000333813
    ALG3Q926853, ENSP000003807934I2D: score=1 STRING: ENSP00000380793
    ALG5Q9Y6733, ENSP000002398914I2D: score=1 STRING: ENSP00000239891
    ALG6Q9Y6723, ENSP000003601494I2D: score=1 STRING: ENSP00000360149
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006488dolichol-linked oligosaccharide biosynthetic process TAS--
    GO:0018279protein N-linked glycosylation via asparagine TAS--
    GO:0043687post-translational protein modification TAS--
    GO:0044267cellular protein metabolic process TAS--

    ALG10B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ALG10B (AG10B)

    1 HMDB Compound for ALG10B    About this table
    CompoundSynonyms CAS #PubMed Ids
    Dolichyl b-D-glucosyl phosphateDolichol monophosphate glucose (see all 10)220496-27-5--

    Search CenterWatch for drugs/clinical trials and news about ALG10B / AG10B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ALG10B gene: 
    NM_001013620.3  

    Unigene Cluster for ALG10B:

    ALG10B, alpha-1,2-glucosyltransferase
    Hs.259305  [show with all ESTs]
    Unigene Representative Sequence: NM_001013620
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000308742(uc001rln.4) ENST00000551464 ENST00000553138 ENST00000548240

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ALG10B
    8/22 QIAGEN miScript miRNA Assays for microRNAs that regulate ALG10B (see all 22):
    hsa-miR-607 hsa-miR-485-3p hsa-miR-132 hsa-miR-9 hsa-miR-2115 hsa-miR-548x hsa-miR-205* hsa-miR-3121-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ALG10B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ALG10B
    Clone
    Products:
         
    OriGene clones in human, mouse for ALG10B (see all 5)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ALG10B (NM_001013620)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ALG10B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALG10B
    Sirion Biotech Customized lentivirus for stable overexpression of ALG10B 
                         Customized lentivirus expression plasmids for stable overexpression of ALG10B 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ALG10B
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ALG10B
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ALG10B
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ALG10B

    Additional mRNA sequence: 

    AK123102.1 AK307955.1 AY845858.1 BC137413.1 BC137414.1 BC144617.1 

    7 DOTS entries:

    DT.95231180  DT.121140383  DT.433165  DT.100687048  DT.95364811  DT.40120334  DT.100839086 

    8 AceView cDNA sequences:

    CR622214 CD252003 BX401727 AL712776 BX494049 BE242781 BM149103 BE154665 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ALG10B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTGATAATA
    ALG10B Expression
    About this image


    See ALG10B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ALG10B

    SOURCE GeneReport for Unigene cluster: Hs.259305

    UniProtKB/Swiss-Prot: AG10B_HUMAN, Q5I7T1
    Tissue specificity: Highly expressed in heart, placenta, liver, kidney and pancreas. Weakly expressed in lung,
    skeletal muscle and brain

        SABiosciences Custom PCR Arrays for ALG10B
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for ALG10B
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ALG10B
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ALG10B
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ALG10B
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALG10B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ALG10B gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves ALG106
    asparagine-linked glycosylation 10 homolog (yeast,...
    68(a)
    1 → many
    1(15491430-15497448)
    lizard
    (Anolis carolinensis)
    Reptilia ALG106
    Uncharacterized protein
    69(a)
    1 → many
    5(99328812-99340301)
    zebrafish
    (Danio rerio)
    Actinopterygii alg106
    asparagine-linked glycosylation 10
    55(a)
    1 → many
    4(27685063-27690743)
    fruit fly
    (Drosophila melanogaster)
    Insecta Alg106
    Alpha 3 glucosyltransferase
    32(a)
    1 → many
    3L(11158071-11159720)
    worm
    (Caenorhabditis elegans)
    Secernentea tag-1796
    Protein TAG-179
    33(a)
    1 → many
    I(9960370-9961973)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes DIE2(YGR227W)4 Dolichyl-phosphoglucose-dependent alpha-1,2 glucosyltransferase more   --   7(947420-948997) 853142  NP_011743.1 
            Species with no ortholog for ALG10B

    ENSEMBL Gene Tree for ALG10B (if available)
    TreeFam Gene Tree for ALG10B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ALG10B gene
    ALG102  
    1 SIMAP similar gene for ALG10B using alignment to 4 protein entries:     AG10B_HUMAN (see all proteins):
    ALG10

    ALG10B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: AG10B_HUMAN, Q5I7T1
    Polymorphism: Genetic variations in ALG10B may reduce susceptibility to acquired long QT syndrome


    10/408 SNPs in ALG10B are shown (see all 408)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0482174
    ----see VAR_0482172 A G mis40--------
    rs740878081,2
    C,F--38708584(+) GAATCT/CAGTTT 1 -- us2k12Minor allele frequency- C:0.17WA 120
    rs1816760951,2
    --38708641(+) CGAACA/TTTTTT 1 -- us2k10--------
    rs18438741,2
    C,F,H--38708937(-) TTTAGA/GATGGC 1 -- us2k118Minor allele frequency- G:0.02NS EA NA WA CSA 910
    rs1465893381,2
    --38708949(+) CCCTAC/TATTTC 1 -- us2k10--------
    rs1863814881,2
    C--38709066(+) TAAATA/GTCTAG 1 -- us2k10--------
    rs1151710821,2
    C,F--38709098(+) AACGGC/TCCACT 1 -- us2k11Minor allele frequency- T:0.07WA 118
    rs1908580631,2
    --38709303(+) GCTAAA/GCATCA 1 -- us2k10--------
    rs1412767601,2
    C--38709552(+) TATATG/TCCTGC 1 -- us2k10--------
    rs1130480981,2
    C,F--38709557(+) GCCTGT/CCAAAG 1 -- us2k11Minor allele frequency- C:0.00CSA 1

    HapMap Linkage Disequilibrium report for ALG10B (38710380 - 38723528 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/21 variations for ALG10B (see all 21):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2745769CNV Deletion23290073
    esv2362578CNV Deletion18987734
    esv2422349CNV Duplication17116639
    esv2422488CNV Duplication17116639
    nsv8963CNV Loss18304495
    nsv899004CNV Gain21882294
    esv2751097CNV Gain17911159
    nsv898971CNV Gain21882294
    dgv1410n71CNV Gain21882294
    dgv196n27CNV Gain19166990


    Human Gene Mutation Database (HGMD): ALG10B
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ALG10B
    DNA2.0 Custom Variant and Variant Library Synthesis for ALG10B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for ALG10B:    About MalaCards
    long qt syndrome    

    1 disease from the University of Copenhagen DISEASES database for ALG10B:
    Long QT syndrome

    ALG10B for disorders           About GeneDecksing

    Genetic Association Database (GAD): ALG10B

    Export disorders for ALG10B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ALG10B gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with ALG10B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. In vivo identification of genes that modify ether-a-go-go-related gene activity in Caenorhabditis elegans may also affect human cardiac arrhythmia. (PubMed id 15280551)1, 2, 9 Petersen C.I.... Balser J.R. (2004)
    2. HLA-B*5701 genotype is a major determinant of drug-in duced liver injury due to flucloxacillin. (PubMed id 19483685)1, 4 Daly A.K....Day C.P. (2009)
    3. The IKr drug response is modulated by KCR1 in transfected cardiac and noncardiac cell lines. (PubMed id 14525949)1, 2 Kupershmidt S.... Balser J.R. (2003)
    4. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    5. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    6. A KCR1 variant implicated in susceptibility to the lo ng QT syndrome. (PubMed id 20950623)1 Hayashi K....Yamagishi M. (2011)
    7. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    8. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)2 Scherer S.E.... Gibbs R.A. (2006)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 144245 HGNC: 31088 AceView: LOC144245 Ensembl:ENSG00000175548 euGenes: HUgn144245
    ECgene: ALG10B Kegg: 144245 H-InvDB: ALG10B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ALG10B Pharmacogenomics, SNPs, Pathways
    GGDBhttp://riodb.ibase.aist.go.jp/rcmg/ggdb/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ALG10B gene:
    Search GeneIP for patents involving ALG10B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for ALG10B  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for ALG10B  
     OriGene qSTAR qPCR primer pairs in human, mouse for ALG10B   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ALG10B   OriGene Custom Protein Services for ALG10B  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ALG10B
     QIAGEN SeqTarget long-range PCR primers for resequencing ALG10B
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ALG10B
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ALG10B
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ALG10B
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ALG10B
     GenScript Custom Purified and Recombinant Proteins Services for ALG10B GenScript cDNA clones with any tag delivered in your preferred vector for ALG10B
     GenScript Custom Assay Services for ALG10B GenScript Custom Superior Antibodies Services for ALG10B
     GenScript Custom overexpressing Cell Line Services for ALG10B CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in ALG10B promoter
     Search Chromatin IP Primers for ALG10B
     RT2 qPCR Primer Assay in human, mouse / rat ALG10B
     Search GNC Networks for ALG10B
     SABiosciences Custom PCR Arrays for ALG10B
     Search Tocris compounds for ALG10B (AG10B)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Biologicals
     Novus Tissue Slides
     Antibodies for ALG10B
     See all of Abcam's Antibodies, Kits and Proteins for ALG10B
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for ALG10B
     Antibodies for ALG10B
     ELISAs for ALG10B
     CLIAs for ALG10B
     Search LifeMap BioReagents cell lines for ALG10B
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALG10B
     Browse SwitchGear 3'UTR luciferase reporter plasmids for ALG10B
     SwitchGear Promoter luciferase reporter plasmids for ALG10B
     ThermoFisher Antibodies for ALG10B
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALG10B
     inGenious Targeting Laboratory - Custom generated mouse model solutions for ALG10B
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ALG10B
    Customized:
     lentivirus for stable overexpression of ALG10B
     lentivirus expression plasmids for stable overexpression of ALG10B
     adenovirus for overexpression of ALG10B
     LSBio Antibodies in human, mouse, rat for ALG10B
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ALG10B gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4