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Aliases for ALG10 Gene

Aliases for ALG10 Gene

  • ALG10, Alpha-1,2-Glucosyltransferase 2 3 5
  • Dolichyl-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dolichol Alpha-1,2- Glucosyltransferase 2 3
  • Asparagine-Linked Glycosylation Protein 10 Homolog A 3 4
  • Alpha-1,2-Glucosyltransferase ALG10-A 3 4
  • Alpha-2-Glucosyltransferase ALG10-A 3 4
  • ALG10A 3 4
  • Asparagine-Linked Glycosylation 10, Alpha-1,2-Glucosyltransferase Homolog (S. Pombe) 2
  • Asparagine-Linked Glycosylation 10, Alpha-1,2-Glucosyltransferase Homolog (Yeast) 2
  • Asparagine-Linked Glycosylation 10 Homolog (Yeast, Alpha-1,2-Glucosyltransferase) 3
  • Asparagine-Linked Glycosylation 10, Alpha-1,2-Glucosyltransferase Homolog 3
  • Derepression Of ITR1 Expression 2 Homolog (S. Cerevisiae) 2
  • Derepression Of ITR1 Expression 2 Homolog 3
  • Potassium Channel Regulator 1 3
  • Alpha2-Glucosyltransferase 3
  • EC 2.4.1.256 4
  • EC 2.4.1.16 63
  • EC 2.4.1 63
  • DIE2 3
  • KCR1 3

External Ids for ALG10 Gene

Previous GeneCards Identifiers for ALG10 Gene

  • GC12P034075
  • GC12P034066
  • GC12P033915

Summaries for ALG10 Gene

Entrez Gene Summary for ALG10 Gene

  • This gene encodes a membrane-associated protein that adds the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. That is, it transfers the terminal glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc2Man9GlcNAc(2)-PP-Dol. The rat protein homolog was shown to specifically modulate the gating function of the rat neuronal ether-a-go-go (EAG) potassium ion channel. [provided by RefSeq, Jan 2010]

GeneCards Summary for ALG10 Gene

ALG10 (ALG10, Alpha-1,2-Glucosyltransferase) is a Protein Coding gene. Diseases associated with ALG10 include long qt syndrome 2. Among its related pathways are Metabolism and Transport to the Golgi and subsequent modification. GO annotations related to this gene include transferase activity, transferring hexosyl groups and dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity. An important paralog of this gene is ALG10B.

UniProtKB/Swiss-Prot for ALG10 Gene

  • Adds the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ALG10 Gene

Genomics for ALG10 Gene

Regulatory Elements for ALG10 Gene

Promoters for ALG10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ALG10 on UCSC Golden Path with GeneCards custom track

Genomic Location for ALG10 Gene

Chromosome:
12
Start:
34,022,281 bp from pter
End:
34,029,694 bp from pter
Size:
7,414 bases
Orientation:
Plus strand

Genomic View for ALG10 Gene

Genes around ALG10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ALG10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ALG10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ALG10 Gene

Proteins for ALG10 Gene

  • Protein details for ALG10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5BKT4-AG10A_HUMAN
    Recommended name:
    Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase
    Protein Accession:
    Q5BKT4
    Secondary Accessions:
    • Q6NS98
    • Q96DU0
    • Q96SM6

    Protein attributes for ALG10 Gene

    Size:
    473 amino acids
    Molecular mass:
    55606 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB55272.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ALG10 Gene

Proteomics data for ALG10 Gene at MOPED

Selected DME Specific Peptides for ALG10 Gene

Post-translational modifications for ALG10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ALG10 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for ALG10 Gene

Gene Families for ALG10 Gene

Protein Domains for ALG10 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ALG10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5BKT4

UniProtKB/Swiss-Prot:

AG10A_HUMAN :
  • Belongs to the ALG10 glucosyltransferase family.
Family:
  • Belongs to the ALG10 glucosyltransferase family.
genes like me logo Genes that share domains with ALG10: view

Function for ALG10 Gene

Molecular function for ALG10 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Dolichyl beta-D-glucosyl phosphate + D-Glc-alpha-(1->3)-D-Glc-alpha-(1->3)-D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->2)-D-Man-alpha-(1->6))-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = D-Glc-alpha-(1->2)-D-Glc-alpha-(1->3)-D-Glc-alpha-(1->3)-D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->2)-D-Man-alpha-(1->6))-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate.
UniProtKB/Swiss-Prot Function:
Adds the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol.

Enzyme Numbers (IUBMB) for ALG10 Gene

genes like me logo Genes that share phenotypes with ALG10: view

Animal Models for ALG10 Gene

MGI Knock Outs for ALG10:

Animal Model Products

CRISPR Products

miRNA for ALG10 Gene

miRTarBase miRNAs that target ALG10

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ALG10 Gene

Localization for ALG10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ALG10 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ALG10 Gene COMPARTMENTS Subcellular localization image for ALG10 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3

No data available for Gene Ontology (GO) - Cellular Components for ALG10 Gene

Pathways & Interactions for ALG10 Gene

genes like me logo Genes that share pathways with ALG10: view

UniProtKB/Swiss-Prot Q5BKT4-AG10A_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Gene Ontology (GO) - Biological Process for ALG10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006486 protein glycosylation IEA --
GO:0006488 dolichol-linked oligosaccharide biosynthetic process IEA --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with ALG10: view

No data available for SIGNOR curated interactions for ALG10 Gene

Drugs & Compounds for ALG10 Gene

(1) Drugs for ALG10 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Gemcitabine Approved Pharma Ribonucleotide reductase and DNA synthesis inhibitor, Nucleoside Analogs 1881

(2) Additional Compounds for ALG10 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Dolichol-20
  • Dolichol
  • Dolichol (C100)
  • Dolichol 20
  • Dolichol phosphate
  • Dolichyl phosphate
2067-66-5
Dolichyl b-D-glucosyl phosphate
  • Dolichol monophosphate glucose
  • Dolichyl b-D-glucosyl phosphate
  • Dolichyl b-delta-glucosyl phosphate
  • Dolichyl beta-D-glucosyl phosphate
  • Dolichyl beta-delta-glucosyl phosphate
220496-27-5
genes like me logo Genes that share compounds with ALG10: view

Transcripts for ALG10 Gene

Unigene Clusters for ALG10 Gene

ALG10, alpha-1,2-glucosyltransferase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ALG10 Gene

No ASD Table

Relevant External Links for ALG10 Gene

GeneLoc Exon Structure for
ALG10
ECgene alternative splicing isoforms for
ALG10

Expression for ALG10 Gene

mRNA expression in normal human tissues for ALG10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ALG10 Gene

This gene is overexpressed in Placenta (43.5), Platelet (17.0), and Blymphocyte (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for ALG10 Gene



SOURCE GeneReport for Unigene cluster for ALG10 Gene Hs.102971

genes like me logo Genes that share expression patterns with ALG10: view

Protein tissue co-expression partners for ALG10 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ALG10 Gene

Orthologs for ALG10 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ALG10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ALG10 35
  • 98.87 (n)
  • 98.73 (a)
ALG10 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ALG10 36
  • 93 (a)
OneToMany
ALG10 35
  • 90.77 (n)
  • 92.81 (a)
dog
(Canis familiaris)
Mammalia ALG10 35
  • 90.77 (n)
  • 94.08 (a)
-- 36
  • 93 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Alg10b 16
Alg10b 35
  • 83.44 (n)
  • 86.26 (a)
Alg10b 36
  • 86 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 79 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 76 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Alg10 35
  • 84.85 (n)
  • 86.89 (a)
chicken
(Gallus gallus)
Aves ALG10 36
  • 68 (a)
OneToMany
ALG10 35
  • 71.2 (n)
  • 68.58 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 69 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia alg10 35
  • 66.52 (n)
  • 63.54 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100331575 35
  • 59.38 (n)
  • 56.26 (a)
alg10 36
  • 56 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002420 35
  • 45.43 (n)
  • 39.14 (a)
fruit fly
(Drosophila melanogaster)
Insecta Alg10 35
  • 45.3 (n)
  • 34.22 (a)
Alg10 36
  • 33 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tag-179 36
  • 33 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL138C 35
  • 44.61 (n)
  • 34.34 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DIE2 35
  • 46.21 (n)
  • 35.35 (a)
DIE2 36
  • 26 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E15797g 35
  • 45.13 (n)
  • 32.08 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G02410 35
  • 47.4 (n)
  • 35.32 (a)
rice
(Oryza sativa)
Liliopsida Os04g0503700 35
  • 48.18 (n)
  • 34.31 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes alg10 35
  • 49.3 (n)
  • 41.94 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14005 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
OneToMany
Species with no ortholog for ALG10:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ALG10 Gene

ENSEMBL:
Gene Tree for ALG10 (if available)
TreeFam:
Gene Tree for ALG10 (if available)

Paralogs for ALG10 Gene

Paralogs for ALG10 Gene

(1) SIMAP similar genes for ALG10 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ALG10: view

Variants for ALG10 Gene

Sequence variations from dbSNP and Humsavar for ALG10 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs366873 -- 34,024,912(-) TTACC(A/G)AATGC intron-variant
rs1211643 -- 34,023,121(-) GTGAG(A/C)TAAAG intron-variant
rs7308242 -- 34,023,861(+) TCAAA(A/G)TTTCT intron-variant
rs11053061 -- 34,024,622(+) aaccc(A/T)tagtg intron-variant
rs11053062 -- 34,024,967(+) GATAG(G/T)GCTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ALG10 Gene

Variant ID Type Subtype PubMed ID
dgv496e1 CNV Complex 17122850
esv34883 CNV Gain 17911159
nsv469348 CNV Gain 19166990
nsv818908 CNV Gain 17921354
nsv469350 CNV Gain 19166990
nsv523443 CNV Gain 19592680
essv7210 CNV CNV 17122850
esv2677888 CNV Deletion 23128226
nsv520568 CNV Gain 19592680
nsv527701 CNV Gain 19592680
dgv497e1 CNV Complex 17122850
dgv498e1 CNV Complex 17122850

Variation tolerance for ALG10 Gene

Residual Variation Intolerance Score: 58.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.31; 26.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ALG10 Gene

HapMap Linkage Disequilibrium report
ALG10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ALG10 Gene

Disorders for ALG10 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ALG10 Gene - From: OMIM and ClinVar

Disorder Aliases PubMed IDs
long qt syndrome 2
  • long qt syndrome 9
- elite association - COSMIC cancer census association via MalaCards
Search ALG10 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ALG10

Genetic Association Database (GAD)
ALG10
Human Genome Epidemiology (HuGE) Navigator
ALG10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ALG10
genes like me logo Genes that share disorders with ALG10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ALG10 Gene

Publications for ALG10 Gene

  1. Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease. (PMID: 19204726) Chapuis J. … Lambert J.C. (Mol. Psychiatry 2009) 3 48 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study. (PMID: 17903297) Seshadri S. … Wolf P.A. (BMC Med. Genet. 2007) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3

Products for ALG10 Gene

Sources for ALG10 Gene

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