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Aliases for ALDOC Gene

Aliases for ALDOC Gene

  • Aldolase C, Fructose-Bisphosphate 2 3
  • Brain-Type Aldolase 3 4
  • EC 4 64
  • ALDC 3 4
  • Fructose-1,6-Biphosphate Triosephosphate Lyase 3
  • Fructose-Bisphosphate Aldolase C 3
  • Fructoaldolase C 3
  • Aldolase 3 3

External Ids for ALDOC Gene

Summaries for ALDOC Gene

Entrez Gene Summary for ALDOC Gene

  • This gene encodes a member of the class I fructose-biphosphate aldolase gene family. Expressed specifically in the hippocampus and Purkinje cells of the brain, the encoded protein is a glycolytic enzyme that catalyzes the reversible aldol cleavage of fructose-1,6-biphosphate and fructose 1-phosphate to dihydroxyacetone phosphate and either glyceraldehyde-3-phosphate or glyceraldehyde, respectively. [provided by RefSeq, Jul 2008]

GeneCards Summary for ALDOC Gene

ALDOC (Aldolase C, Fructose-Bisphosphate) is a Protein Coding gene. Diseases associated with ALDOC include eumycotic mycetoma and mycetoma. Among its related pathways are Metabolism and Carbon metabolism. GO annotations related to this gene include cytoskeletal protein binding and fructose-bisphosphate aldolase activity. An important paralog of this gene is ALDOB.

Gene Wiki entry for ALDOC Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ALDOC Gene

Genomics for ALDOC Gene

Genomic Location for ALDOC Gene

28,573,115 bp from pter
28,577,264 bp from pter
4,150 bases
Minus strand

Genomic View for ALDOC Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ALDOC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ALDOC Gene

Regulatory Elements for ALDOC Gene

Proteins for ALDOC Gene

  • Protein details for ALDOC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Fructose-bisphosphate aldolase C
    Protein Accession:
    Secondary Accessions:
    • B2R5R3
    • Q3SYL3
    • Q6FH94
    • Q6P0L5

    Protein attributes for ALDOC Gene

    364 amino acids
    Molecular mass:
    39456 Da
    Quaternary structure:
    • Homotetramer. Interacts with ATP6V1E1. May interact with PLD2.
    • In vertebrates, three forms of this ubiquitous glycolytic enzyme are found, aldolase A in muscle, aldolase B in liver and aldolase C in brain
    • Sequence=AAI03761.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ALDOC Gene

neXtProt entry for ALDOC Gene

Proteomics data for ALDOC Gene at MOPED

Post-translational modifications for ALDOC Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys28, Lys42, Lys111, Lys147, Lys200, Lys208, and Lys330

Other Protein References for ALDOC Gene

Domains for ALDOC Gene

Protein Domains for ALDOC Gene


  • Belongs to the class I fructose-bisphosphate aldolase family.:
    • P09972
genes like me logo Genes that share domains with ALDOC: view

No data available for Gene Families for ALDOC Gene

Function for ALDOC Gene

Molecular function for ALDOC Gene

GENATLAS Biochemistry: aldolase C,fructose-bisphosphate,160kDa,fructose metabolism,energy pathway,more affinity for F-1-P than for F-1,6-P
UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=10.7 uM for fructose 1,6-bisphosphate {ECO:0000269 PubMed:15537755}; KM=16 mM for fructose 1-phosphate {ECO:0000269 PubMed:15537755};
UniProtKB/Swiss-Prot CatalyticActivity: D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Enzyme Numbers (IUBMB) for ALDOC Gene

Gene Ontology (GO) - Molecular Function for ALDOC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004332 fructose-bisphosphate aldolase activity IDA 15537755
GO:0005515 protein binding IPI 11399750
GO:0008092 cytoskeletal protein binding IDA 9244396
genes like me logo Genes that share ontologies with ALDOC: view

Phenotypes for ALDOC Gene

genes like me logo Genes that share phenotypes with ALDOC: view

miRNA for ALDOC Gene

miRTarBase miRNAs that target ALDOC

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for ALDOC Gene

Localization for ALDOC Gene

Subcellular locations from

Jensen Localization Image for ALDOC Gene COMPARTMENTS Subcellular localization image for ALDOC gene
Compartment Confidence
cytosol 4
cytoskeleton 3
mitochondrion 2
nucleus 2
chloroplast 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ALDOC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IC 9244396
GO:0030424 axon IEA --
genes like me logo Genes that share ontologies with ALDOC: view

Pathways for ALDOC Gene

genes like me logo Genes that share pathways with ALDOC: view

UniProtKB/Swiss-Prot P09972-ALDOC_HUMAN

  • Pathway: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4

Gene Ontology (GO) - Biological Process for ALDOC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001666 response to hypoxia IEA --
GO:0005975 carbohydrate metabolic process TAS --
GO:0006000 fructose metabolic process TAS 3105602
GO:0006006 glucose metabolic process TAS --
GO:0006094 gluconeogenesis TAS --
genes like me logo Genes that share ontologies with ALDOC: view

Compounds for ALDOC Gene

(6) HMDB Compounds for ALDOC Gene

Compound Synonyms Cas Number PubMed IDs
D-Erythrose 4-phosphate
  • D-Erythrose 4-phosphate
D-Glyceraldehyde 3-phosphate
  • 2-hydroxy-3-(phosphonooxy)-Propanal
Dihydroxyacetone phosphate
  • 1,3-Dihydroxy-2-propanone phosphate
Fructose 1,6-bisphosphate
  • D-Fructose 1,6-biphosphate
Fructose 1-phosphate
  • D-fructose-1-P
genes like me logo Genes that share compounds with ALDOC: view

Transcripts for ALDOC Gene

Unigene Clusters for ALDOC Gene

Aldolase C, fructose-bisphosphate:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ALDOC Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^ 10 ^ 11
SP2: -
SP4: - - - -
SP5: - - -
SP6: -

Relevant External Links for ALDOC Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ALDOC Gene

mRNA expression in normal human tissues for ALDOC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ALDOC Gene

This gene is overexpressed in Brain - Cerebellum (4.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ALDOC Gene

SOURCE GeneReport for Unigene cluster for ALDOC Gene Hs.155247

genes like me logo Genes that share expressions with ALDOC: view

Orthologs for ALDOC Gene

This gene was present in the common ancestor of animals.

Orthologs for ALDOC Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ALDOC 36
  • 99.54 (n)
  • 99.18 (a)
  • 100 (a)
(Bos Taurus)
Mammalia ALDOC 36
  • 92.67 (n)
  • 98.63 (a)
  • 99 (a)
(Canis familiaris)
Mammalia ALDOC 36
  • 93.32 (n)
  • 98.63 (a)
  • 80 (a)
(Mus musculus)
Mammalia Aldoc 36
  • 90.54 (n)
  • 97.8 (a)
Aldoc 16
Aldoc 37
  • 98 (a)
(Monodelphis domestica)
Mammalia ALDOC 37
  • 95 (a)
(Ornithorhynchus anatinus)
Mammalia ALDOC 37
  • 91 (a)
(Rattus norvegicus)
Mammalia Aldoc 36
  • 90.45 (n)
  • 96.97 (a)
(Gallus gallus)
Aves ALDOC 36
  • 81.5 (n)
  • 91.76 (a)
  • 92 (a)
(Anolis carolinensis)
Reptilia ALDOC 37
  • 87 (a)
African clawed frog
(Xenopus laevis)
Amphibia aldoc-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia aldoc 36
  • 77.29 (n)
  • 86.26 (a)
Str.3134 36
(Danio rerio)
Actinopterygii -- 36
aldoca 37
  • 79 (a)
aldocb 36
  • 76.49 (n)
  • 84.85 (a)
fruit fly
(Drosophila melanogaster)
Insecta Ald 37
  • 67 (a)
CG5432 37
  • 57 (a)
Ald 38
  • 70 (a)
CG5432 38
  • 58 (a)
(Caenorhabditis elegans)
Secernentea aldo-1 36
  • 60.41 (n)
  • 65.27 (a)
aldo-1 37
  • 64 (a)
aldo-2 37
  • 61 (a)
F01F1.12b 38
  • 62 (a)
T05D4.1 38
  • 65 (a)
F01F1.12a 38
  • 61 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5322 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11039 37
  • 70 (a)
Species with no ortholog for ALDOC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ALDOC Gene

Gene Tree for ALDOC (if available)
Gene Tree for ALDOC (if available)

Paralogs for ALDOC Gene

Paralogs for ALDOC Gene

Selected SIMAP similar genes for ALDOC Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with ALDOC: view

Variants for ALDOC Gene

Sequence variations from dbSNP and Humsavar for ALDOC Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs2228419 -- 28,574,176(-) CTCAA(A/G)CCCAA synonymous-codon, reference
rs2229541 -- 28,574,846(-) GATGG(A/G)CTCTC synonymous-codon, reference
rs3095126 -- 28,576,779(-) CGGGA(C/G)CCACT intron-variant
rs11559066 -- 28,575,135(-) ATCGT(C/T)GTGGG reference, synonymous-codon
rs34165301 -- 28,575,827(+) CTTCT(A/G)ATAAA intron-variant

Relevant External Links for ALDOC Gene

HapMap Linkage Disequilibrium report

No data available for Structural Variations from Database of Genomic Variants (DGV) for ALDOC Gene

Disorders for ALDOC Gene

(2) MalaCards Diseases for ALDOC Gene

Search for ALDOC Gene in MalaCards »

(1) University of Copenhagen DISEASES for ALDOC Gene

genes like me logo Genes that share disorders with ALDOC: view

No data available for UniProtKB/Swiss-Prot for ALDOC Gene

Publications for ALDOC Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Structure of human brain fructose 1,6-(bis)phosphate aldolase: linking isozyme structure with function. (PMID: 15537755) Arakaki T.L. … Allen K.N. (Protein Sci. 2004) 3 4
  3. Proteome analysis of schizophrenia patients Wernicke's area reveals an energy metabolism dysregulation. (PMID: 19405953) Martins-de-Souza D. … Dias-Neto E. (BMC Psychiatry 2009) 3 23
  4. Characterization of the transcription-initiation site and of the promoter region within the 5' flanking region of the human aldolase C gene. (PMID: 2209624) Buono P. … Salvatore F. (Eur. J. Biochem. 1990) 3 4
  5. The complete amino acid sequence of the human aldolase C isozyme derived from genomic clones. (PMID: 3105602) Rottmann W.H. … Tolan D.R. (Biochimie 1987) 3 4

Products for ALDOC Gene

Sources for ALDOC Gene

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