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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ALDOC Gene

protein-coding GIFtS: 66
GCID: GC17M026900

aldolase C, fructose-bisphosphate

Explore 16 diseases affiliated with
ALDOC via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Aldolase C, Fructose-Bisphosphate¹ ²		Aldolase 3²
Brain-Type Aldolase² ³		Fructoaldolase C²
ALDC² ³		Fructose-1,6-Biphosphate Triosephosphate Lyase²
EC 4.1.2.13³ ⁸		Fructose-Bisphosphate Aldolase C²

External Ids:	HGNC: 418¹	Entrez Gene: 230²	Ensembl: ENSG00000109107⁷	OMIM: 103870⁵	UniProtKB: P09972³

Export aliases for ALDOC gene to outside databases

Previous GC identifers: GC17M026745 GC17M028799 GC17M027045 GC17M023924 GC17M023109

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ALDOC:

This gene encodes a member of the class I fructose-biphosphate aldolase gene family. Expressed specifically in the

hippocampus and Purkinje cells of the brain, the encoded protein is a glycolytic enzyme that catalyzes the reversible

aldol cleavage of fructose-1,6-biphosphate and fructose 1-phosphate to dihydroxyacetone phosphate and either

glyceraldehyde-3-phosphate or glyceraldehyde, respectively. (provided by RefSeq, Jul 2008)

Gene Wiki entry for ALDOC (Aldolase C)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.1 NT_010799.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ALDOC gene promoter:
c-Fos AP-1 ATF-2 c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ALDOC promoter sequence

Search SABiosciences Chromatin IP Primers for ALDOC

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ALDOC

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17cen-q12 Ensembl cytogenetic band: 17q11.2 HGNC chromosome: 17

ALDOC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ALDOC gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17M026900: view genomic region (about GC identifiers)

Start:	26,900,133 bp from pter	End:	26,904,282 bp from pter
Size:	4,150 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ALDOC_HUMAN, P09972 (See protein sequence)

Recommended Name: Fructose-bisphosphate aldolase C

Size: 364 amino acids; 39456 Da

Subunit: Homotetramer. Interacts with ATP6V1E1. May interact with PLD2

Miscellaneous: In vertebrates, three forms of this ubiquitous glycolytic enzyme are found, aldolase A in muscle,

aldolase B in liver and aldolase C in brain

Sequence caution: Sequence=AAI03761.1; Type=Erroneous initiation;

1 PDB 3D structure from and Proteopedia for ALDOC:

1XFB (3D)

Secondary accessions: B2R5R3 Q3SYL3 Q6FH94 Q6P0L5

Explore the universe of human proteins at neXtProt for ALDOC: NX_P09972

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P09972

4/31 DME Specific Peptides for ALDOC (P09972) (see all 31)

GIVVGIK

PDGDHDL

LARYASI

PWALTFS

ALDOC Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_005156.1

ENSEMBL proteins:

ENSP00000378729 ENSP00000378731 ENSP00000226253 ENSP00000463174 ENSP00000462674

ENSP00000465623 ENSP00000398976 ENSP00000463118

Reactome Protein details: P09972
Human Recombinant Protein Products for ALDOC:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: ALDOC OriGene Protein Over-expression Lysate: ALDOC OriGene Custom Protein Services for ALDOC
	GenScript Custom Purified and Recombinant Proteins Services for ALDOC
	Novus Biologicals ALDOC Proteins Novus Biologicals ALDOC Lysate
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for ALDOC
	Uscn Proteins for ALDOC

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	--	--
GO:0005739	mitochondrion	IEA	--
GO:0005829	cytosol	TAS	--
GO:0005856	cytoskeleton	IC	9244396
GO:0030424	axon	IEA	--

ALDOC for ontologies About GeneDecksing

ALDOC Antibody Products:

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	Abcam antibodies for ALDOC
	Uscn Antibodies for ALDOC
	ThermoFisher Antibodies for ALDOC

Assay Products for ALDOC:

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	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
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	GenScript Custom Assay Services for ALDOC
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	Uscn ELISAs and CLIAs for ALDOC

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ALDOC for domains About GeneDecksing

2 InterPro domains/families:

IPR013785 Aldolase_TIM

IPR000741 Aldolase_I

Graphical View of Domain Structure for InterPro Entry P09972

ProtoNet protein and cluster: P09972

1 Blocks protein family: IPB000741 Fructose-bisphosphate aldolase

UniProtKB/Swiss-Prot: ALDOC_HUMAN, P09972

Similarity: Belongs to the class I fructose-bisphosphate aldolase family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: ALDOC_HUMAN, P09972

Catalytic activity: D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate

Biophysicochemical properties: Kinetic parameters: KM=10.7 uM for fructose 1,6-bisphosphate; KM=16 mM for fructose

1-phosphate;

Genatlas biochemistry entry for ALDOC:

aldolase C,fructose-bisphosphate,160kDa,fructose metabolism,energy pathway,more affinity for F-1-P than for F-1,6-P

Enzyme Number (IUBMB): EC 4.1.2.13¹ ²

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004332	fructose-bisphosphate aldolase activity	IDA	9244396
GO:0005515	protein binding	IPI	11399750
GO:0008092	cytoskeletal protein binding	IDA	9244396

ALDOC for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for ALDOC:

Increased gamma-H2AX phosphory

Synthetic lethal with imatinib

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ALDOC

miRNA Products:		OriGene 3'-UTR Clone: ALDOC Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ALDOC
		5 QIAGEN miScript miRNA Assays for microRNAs that regulate ALDOC:
		hsa-miR-2052 hsa-miR-4307 hsa-miR-19b-1* hsa-miR-19b-2* hsa-miR-19a*
		SwitchGear 3'UTR luciferase reporter plasmid: ALDOC 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ALDOC (see all 7) OriGene shRNA RFP: ALDOC OriGene siRNA: ALDOC
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		Sirion Biotech Custom design and validation of potent shRNA sequences against ALDOC

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for ALDOC
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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ALDOC (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ALDOC (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ALDOC (NM_005165)
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALDOC

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Glycolysis and gluconeogenesis (short map)

	Glycolysis and gluconeogenesis (short map)	1.00			Glycolysis and Gluconeogenesis	0.60
	Glycolysis and gluconeogenesis (short map)	0.97			Glycolysis / Gluconeogenesis	0.41

Glucose metabolism

	Glucose metabolism	1.00			Glycolysis	0.44
	Gluconeogenesis	0.50

Metabolism

Metabolism

1.00

Metabolic pathways

0.38

gluconeogenesis I

gluconeogenesis I

1.00

glycolysis I

0.58

Fructose and mannose metabolism

Fructose and mannose metabolism

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for ALDOC

Glycolysis and gluconeogenesis (short map)

1 GeneGo (Thomson Reuters) Pathway for ALDOC

Glycolysis and gluconeogenesis (short map)

4 BioSystems Pathways for ALDOC

	Glycolysis and Gluconeogenesis
	sucrose degradation V (mammalian)
	glycolysis I
	gluconeogenesis I

5 Reactome Pathways for ALDOC

	Gluconeogenesis
	Metabolism of carbohydrates
	Metabolism
	Glucose metabolism
	Glycolysis

4 Kegg Pathways (Kegg details for ALDOC):

	Glycolysis / Gluconeogenesis
	Pentose phosphate pathway
	Fructose and mannose metabolism
	Metabolic pathways

UniProtKB/Swiss-Prot: ALDOC_HUMAN, P09972

Pathway: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose:

step 4/4

ALDOC for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ALDOC

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/57 Interacting proteins for ALDOC (P09972³ ENSP00000226253⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 57)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ATP6V1E1	P36543³, ENSP00000253413⁴	I2D: score=1 STRING: ENSP00000253413
PLD2	O14939³, ENSP00000263088⁴	I2D: score=2 STRING: ENSP00000263088
UBC	P0CG48³, ENSP00000344818⁴	I2D: score=1 STRING: ENSP00000344818
ATG5	Q9H1Y0³	I2D: score=1
DDIT3	P35638³	I2D: score=1

About this table

Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001666	response to hypoxia	IEA	--
GO:0005975	carbohydrate metabolic process	TAS	--
GO:0006000	fructose metabolic process	TAS	3105602
GO:0006006	glucose metabolic process	TAS	--
GO:0006094	gluconeogenesis	TAS	--

ALDOC for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ALDOC

6 HMDB Compounds for ALDOC About this table

Compound	Synonyms	CAS #	PubMed Ids
D-Erythrose 4-phosphate	D-Erythrose 4-phosphate (see all 11)	585-18-2	--
D-Glyceraldehyde 3-phosphate	2-hydroxy-3-(phosphonooxy)-Propanal (see all 11)	142-10-9	--
Dihydroxyacetone phosphate	1,3-Dihydroxy-2-propanone phosphate (see all 17)	57-04-5	--
Fructose 1,6-bisphosphate	D-Fructose 1,6-biphosphate (see all 16)	488-69-7	--
Fructose 1-phosphate	D-fructose-1-P (see all 7)	15978-08-2	--
Zinc	Zinc (see all 2)	7440-66-6	--

Search CenterWatch for drugs/clinical trials and news about ALDOC

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ALDOC gene:

NM_005165.2

Unigene Cluster for ALDOC:

Aldolase C, fructose-bisphosphate

Hs.155247 [show with all ESTs]

Unigene Representative Sequence: BM458181

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000395319 ENST00000395321 ENST00000226253(uc002hbp.3) ENST00000460201

ENST00000584086 ENST00000581807 ENST00000435638 ENST00000578590 ENST00000582381

miRNA Products:		OriGene 3'-UTR Clone: ALDOC Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ALDOC
		5 QIAGEN miScript miRNA Assays for microRNAs that regulate ALDOC:
		hsa-miR-2052 hsa-miR-4307 hsa-miR-19b-1* hsa-miR-19b-2* hsa-miR-19a*
		SwitchGear 3'UTR luciferase reporter plasmid: ALDOC 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ALDOC (see all 7) OriGene shRNA RFP: ALDOC OriGene siRNA: ALDOC
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ALDOC
		Sirion Biotech Custom design and validation of potent shRNA sequences against ALDOC

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ALDOC (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ALDOC (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ALDOC (NM_005165)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ALDOC
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALDOC

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ALDOC Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat ALDOC
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ALDOC
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ALDOC

Additional cDNA sequence:

AF054987.1 AK293453.1 AK293623.1 AK293693.1 AK294091.1 AK294157.1 AK296039.1 AK296053.1

AK312281.1 BC003613.2 BC065565.1 BC103760.1 BC106925.1 BC106926.1 BT007006.1 CR541862.1

CR541881.1

20 DOTS entries:

DT.454051 DT.95276593 DT.100693364 DT.100882639 DT.91694292 DT.100882646 DT.120959743 DT.100882642

DT.102843805 DT.100882649 DT.100882626 DT.120959667 DT.100882625 DT.120959684 DT.120959745 DT.120959746

DT.120959815 DT.95276567 DT.95276575 DT.99937107

24/680 AceView cDNA sequences (see all 680):

CR622257 CB154585 AA594379 F09275 BX333597 BX422889 BP381328 BG818262

BQ879022 AU142755 AA317368 CB146084 BM809937 BQ639039 AI919462 CD675977

CR607475 BE304489 CR599491 AA219582 BQ716849 BP347886 BP347507 AV728719

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ALDOC (see all 6) About this scheme

ExUns:	1a	·	1b	^	2	^	3a	·	3b	·	3c	^	4a	·	4b	^	5a	·	5b	^	6a	·	6b	·	6c	^	7	^	8a	·	8b	^	9a	·	9b	·	9c	·	9d	^	10	^	11
SP1:
SP2:					-
SP3:
SP4:																							-		-		-		-
SP5:					-										-		-

ECgene alternative splicing isoforms for ALDOC

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ALDOC expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCTTGAGTAC

About this image

ALDOC expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Neural Tube

Presumptive Spinal Cord

Spinal Cord

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Mature follicles (In-vitro growth and ...)

See ALDOC Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ALDOC

SOURCE GeneReport for Unigene cluster: Hs.155247

SABiosciences Expression via Pathway-Focused PCR Array including ALDOC:

Glucose Metabolism in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ALDOC Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat ALDOC
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ALDOC
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ALDOC

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALDOC

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for ALDOC gene from 8/27 species (see all 27) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	ALDOC¹	aldolase C, fructose-bisphosphate	81.5(n) 91.76(a)		395492 NM_001206496.1 NP_001193425.1
lizard (Anolis carolinensis)	Reptilia	ALDOC⁶	--	87(a)	1 ↔ 1	GL343470.1(444021-449462)
African clawed frog (Xenopus laevis)	Amphibia	aldoc-prov²	aldolase C, fructose-bisphosphate	78.98(n)		BC045218.1
zebrafish (Danio rerio)	Actinopterygii	AF533647.1²	--	77.5(n)		369193 AF533647.1
fruit fly (Drosophila melanogaster)	Insecta	Ald³	glycolysis fructose-bisphosphate aldolase	70(a) (best of 2)		3 97A6 --
worm (Caenorhabditis elegans)	Secernentea	T05D4.1³	Fructose-bisphosphate aldolase class-I	65(a) (best of 3)		III(13634767-13636203) --
thale cress (Arabidopsis thaliana)	eudicotyledons	AT4G26530⁶ AT3G52930⁶ (see all 8)	fructose-bisphosphate aldolase, class I (see all 8)	59(a) 58(a) (see all 8)	many ↔ many many ↔ many (see all 8)	4(13391293-13393107) 3(19626748-19629073)
rice (Oryza sativa)	Liliopsida	Os08g0120600¹	hypothetical protein	58.05(n) 57.3(a)		4344545 NM_001067415.1 NP_001060880.1

ENSEMBL Gene Tree for ALDOC (if available)
TreeFam Gene Tree for ALDOC (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ALDOC gene

ALDOA² ALDOB²

2 SIMAP similar genes for ALDOC using alignment to 7 protein entries: ALDOC_HUMAN (see all proteins):

ALDOA ALDOB

ALDOC for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs189353781^1,2		--	26899723(+)	`GGAAGG/TTACCA`	2	--	us2k¹ ds500¹		0	--	--	--	--
rs3132813^1,2	H	--	26899897(-)	`GACTGG/CCACAT`	2	--	ds500¹ us2k¹		4		NS EA	382
rs147645618^1,2		--	26899926(+)	`TTCCTA/CATTGC`	2	--	us2k¹ ds500¹		0	--	--	--	--
rs114752419^1,2	F	--	26900070(+)	`AGAGAT/CAGAAT`	2	--	us2k¹ ds500¹		1		WA	118
rs140581685^1,2		--	26900093(+)	`GAAACC/TGGGAG`	2	--	ds500¹ us2k¹		0	--	--	--	--
rs182033472^1,2		--	26900161(+)	`TTGCTA/GTATGG`	2	--	us2k¹ ut3¹		0	--	--	--	--
rs144495937^1,2		--	26900346(+)	`CCTCAC/GTCATG`	2	--	ut3¹ us2k¹		0	--	--	--	--
rs117983797^1,2	C,F	--	26900382(+)	`TGGTCC/TCAGGT`	2	--	us2k¹ ut3¹		1		NA	120
rs41280130^1,2	C	--	26900653(+)	`GGGAGC/TGTGGA`	2	--	us2k¹ int¹		0	--	--	--	--
rs185997454^1,2	C	--	26900676(+)	`AGCCAA/GCCCAC`	2	--	us2k¹ int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ALDOC (26900133 - 26904282 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ALDOC: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ALDOC for disorders           About GeneDecksing

OMIM gene information: 103870    OMIM disorders: --

16 diseases for ALDOC:    About MalaCards

eumycotic mycetoma aldolase a deficiency fructose intolerance borna disease

giardiasis mycetoma down syndrome hypogonadism

alzheimer's disease obesity hypertension hypoxia

neuroblastoma schizophrenia malaria neuronitis

Export disorders for ALDOC gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ALDOC gene, integrated from 9 sources (see all 44):
(articles sorted by number of sources associating them with ALDOC)

Utopia: connect your pdf to the dynamic
world of online information

Structure of human brain fructose 1,6-(bis)phosphate aldolase: linking isozyme structure with function. (PubMed id 15537755)^{1, 2} Arakaki T.L.... Allen K.N. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Phospholipase D2 directly interacts with aldolase via Its PH domain. (PubMed id 11876650)^{1, 2} Kim J.H....Ryu S.H. (2002)
Interaction between aldolase and vacuolar H+-ATPase: evidence for direct coupling of glycolysis to the ATP-hydrolyzing proton pump. (PubMed id 11399750)^{1, 2} Lu M.... Gluck S.L. (2001)
Characterization of the transcription-initiation site and of the promoter region within the 5' flanking region of the human aldolase C gene. (PubMed id 2209624)^{1, 2} Buono P.... Salvatore F. (1990)
The complete nucleotide sequence of the gene coding for the human aldolase C. (PubMed id 3267224)^{1, 2} Buono P.... Salvatore F. (1988)
The complete amino acid sequence of the human aldolase C isozyme derived from genomic clones. (PubMed id 3105602)^{1, 2} Rottmann W.H.... Tolan D.R. (1987)
Proteome analysis of schizophrenia patients Wernicke's area reveals an energy metabolism dysregulation. (PubMed id 19405953)^{1, 9} Martins-de-Souza D....Dias-Neto E. (2009)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 230	HGNC: 418	AceView: ALDOC	Ensembl:ENSG00000109107	euGenes: HUgn230
ECgene: ALDOC	Kegg: 230	H-InvDB: ALDOC

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ALDOC	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ALDOC gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ALDOC gene:
Search GeneIP for patents involving ALDOC

Licensable Technologies for ALDOC gene:

Weizmann Institute:

Diagnosis and Treatment of Alzheimer Directed Against Aldolase

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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aldolase C, fructose-bisphosphate

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aldolase C, fructose-bisphosphate

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