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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ALDOC Gene

protein-coding   GIFtS: 66
GCID: GC17M026900

Aldolase C, Fructose-Bisphosphate

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Aldolase C, Fructose-Bisphosphate1 2     Aldolase 32
Brain-Type Aldolase2 3     Fructoaldolase C2
ALDC2 3     Fructose-1,6-Biphosphate Triosephosphate Lyase2
EC 4.1.2.133 8     Fructose-Bisphosphate Aldolase C2

External Ids:    HGNC: 4181   Entrez Gene: 2302   Ensembl: ENSG000001091077   OMIM: 1038705   UniProtKB: P099723   

Export aliases for ALDOC gene to outside databases

Previous GC identifers: GC17M026745 GC17M028799 GC17M027045 GC17M023924 GC17M023109


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ALDOC Gene:
This gene encodes a member of the class I fructose-biphosphate aldolase gene family. Expressed specifically in the
hippocampus and Purkinje cells of the brain, the encoded protein is a glycolytic enzyme that catalyzes the
reversible aldol cleavage of fructose-1,6-biphosphate and fructose 1-phosphate to dihydroxyacetone phosphate and
either glyceraldehyde-3-phosphate or glyceraldehyde, respectively. (provided by RefSeq, Jul 2008)

GeneCards Summary for ALDOC Gene: 
ALDOC (aldolase C, fructose-bisphosphate) is a protein-coding gene. Diseases associated with ALDOC include eumycotic mycetoma, and mycetoma, and among its related super-pathways are Glycolysis and gluconeogenesis (short map) and Metabolic pathways. GO annotations related to this gene include cytoskeletal protein binding and fructose-bisphosphate aldolase activity. An important paralog of this gene is ALDOA.

Gene Wiki entry for ALDOC (Aldolase C) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010799.15  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ALDOC gene promoter:
         c-Fos   AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidALDOC promoter sequence
   Search SABiosciences Chromatin IP Primers for ALDOC

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ALDOC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17cen-q12   Ensembl cytogenetic band:  17q11.2   HGNC cytogenetic band: 17q11.2

ALDOC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ALDOC gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M026900:  view genomic region     (about GC identifiers)

Start:
26,900,133 bp from pter      End:
26,904,282 bp from pter
Size:
4,150 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ALDOC_HUMAN, P09972 (See protein sequence)
Recommended Name: Fructose-bisphosphate aldolase C  
Size: 364 amino acids; 39456 Da
Subunit: Homotetramer. Interacts with ATP6V1E1. May interact with PLD2
Miscellaneous: In vertebrates, three forms of this ubiquitous glycolytic enzyme are found, aldolase A in muscle,
aldolase B in liver and aldolase C in brain
Sequence caution: Sequence=AAI03761.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for ALDOC:
1XFB (3D)    
Secondary accessions: B2R5R3 Q3SYL3 Q6FH94 Q6P0L5

Explore the universe of human proteins at neXtProt for ALDOC: NX_P09972

Explore proteomics data for ALDOC at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P09972

  • 4/31 DME Specific Peptides for ALDOC (P09972) (see all 31)
     GIVVGIK  PDGDHDL  LARYASI  PWALTFS 

    ALDOC Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ALDOC Protein Expression
    REFSEQ proteins: NP_005156.1  
    ENSEMBL proteins: 
     ENSP00000378729   ENSP00000378731   ENSP00000226253   ENSP00000463174   ENSP00000462674  
     ENSP00000465623   ENSP00000398976   ENSP00000463118  
    Reactome Protein details: P09972
    Human Recombinant Protein Products for ALDOC: 
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    Novus Biologicals ALDOC Proteins
    Novus Biologicals ALDOC Lysate
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    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for ALDOC
    Cloud-Clone Corp. Proteins for ALDOC 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005739mitochondrion IEA--
    GO:0005829cytosol TAS--
    GO:0005856cytoskeleton IC9244396
    GO:0030424axon IEA--

    ALDOC for ontologies           About GeneDecksing



    ALDOC Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR013785 Aldolase_TIM
     IPR000741 Aldolase_I

    Graphical View of Domain Structure for InterPro Entry P09972

    ProtoNet protein and cluster: P09972

    1 Blocks protein domain: IPB000741 Fructose-bisphosphate aldolase

    UniProtKB/Swiss-Prot: ALDOC_HUMAN, P09972
    Similarity: Belongs to the class I fructose-bisphosphate aldolase family


    ALDOC for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ALDOC_HUMAN, P09972
    Catalytic activity: D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate
    Biophysicochemical properties: Kinetic parameters: KM=10.7 uM for fructose 1,6-bisphosphate; KM=16 mM for fructose
    1-phosphate;

         Genatlas biochemistry entry for ALDOC:
    aldolase C,fructose-bisphosphate,160kDa,fructose metabolism,energy pathway,more affinity for F-1-P than for
    F-1,6-P

         Enzyme Number (IUBMB): EC 4.1.2.131 2

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004332fructose-bisphosphate aldolase activity IDA15537755
    GO:0005515protein binding IPI11399750
    GO:0008092cytoskeletal protein binding IDA9244396
         
    ALDOC for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ALDOC:
     Increased gamma-H2AX phosphory  Synthetic lethal with imatinib 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ALDOC 
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    SwitchGear 3'UTR luciferase reporter plasmidALDOC 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ALDOC About   (see all 8)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Glycolysis and gluconeogenesis (short map)
    Glycolysis and gluconeogenesis (short map)0.60
    Conversion of glucose to acetyl CoA and entry into the TCA cycle0.46
    Glycolysis and Gluconeogenesis0.60
    Glycolysis / Gluconeogenesis0.46
    glycolysis0.50
    gluconeogenesis0.39
    2Metabolism
    Metabolism0.40
    Metabolic pathways0.40
    3Glucose metabolism
    Glucose metabolism0.50
    Glycolysis0.44
    Gluconeogenesis0.50
    4Carbon metabolism
    Carbon metabolism0.37
    Biosynthesis of amino acids0.37
    5MPS IIIC - Sanfilippo syndrome C
    Metabolism of carbohydrates0.48

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for ALDOC
        Glycolysis and gluconeogenesis (short map)


    1 GeneGo (Thomson Reuters) Pathway for ALDOC
        Glycolysis and gluconeogenesis (short map)

    5 BioSystems Pathways for ALDOC
        Glycolysis and Gluconeogenesis
    sucrose degradation V (mammalian)
    gluconeogenesis
    glycolysis
    Conversion of glucose to acetyl CoA and entry into the TCA cycle


    5        Reactome Pathways for ALDOC
        Gluconeogenesis
    Metabolism of carbohydrates
    Metabolism
    Glucose metabolism
    Glycolysis


    5/6         Kegg Pathways  (Kegg details for ALDOC) (see all 6):
        Glycolysis / Gluconeogenesis
    Pentose phosphate pathway
    Fructose and mannose metabolism
    Metabolic pathways
    Carbon metabolism

    UniProtKB/Swiss-Prot: ALDOC_HUMAN, P09972
    Pathway: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from
    D-glucose: step 4/4


    ALDOC for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ALDOC

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/57 Interacting proteins for ALDOC (P099723 ENSP000002262534) via UniProtKB, MINT, STRING, and/or I2D (see all 57)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATP6V1E1P365433, ENSP000002534134I2D: score=1 STRING: ENSP00000253413
    PLD2O149393, ENSP000002630884I2D: score=2 STRING: ENSP00000263088
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    ATG5Q9H1Y03I2D: score=1 
    DDIT3P356383I2D: score=1 
    About this table

    Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001666response to hypoxia IEA--
    GO:0005975carbohydrate metabolic process TAS--
    GO:0006000fructose metabolic process TAS3105602
    GO:0006006glucose metabolic process TAS--
    GO:0006094gluconeogenesis TAS--

    ALDOC for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ALDOC

    6 HMDB Compounds for ALDOC    About this table
    CompoundSynonyms CAS #PubMed Ids
    D-Erythrose 4-phosphateD-Erythrose 4-phosphate (see all 11)585-18-2--
    D-Glyceraldehyde 3-phosphate2-hydroxy-3-(phosphonooxy)-Propanal (see all 11)142-10-9--
    Dihydroxyacetone phosphate1,3-Dihydroxy-2-propanone phosphate (see all 17)57-04-5--
    Fructose 1,6-bisphosphateD-Fructose 1,6-biphosphate (see all 16)488-69-7--
    Fructose 1-phosphateD-fructose-1-P (see all 7)15978-08-2--
    ZincZinc (see all 2)7440-66-6--

    Search CenterWatch for drugs/clinical trials and news about ALDOC

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ALDOC gene: 
    NM_005165.2  

    Unigene Cluster for ALDOC:

    Aldolase C, fructose-bisphosphate
    Hs.155247  [show with all ESTs]
    Unigene Representative Sequence: BM458181
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000395319 ENST00000395321 ENST00000226253(uc002hbp.3) ENST00000460201
    ENST00000584086 ENST00000581807 ENST00000435638 ENST00000578590 ENST00000582381


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    5 QIAGEN miScript miRNA Assays for microRNAs that regulate ALDOC:
    hsa-miR-2052 hsa-miR-4307 hsa-miR-19b-1* hsa-miR-19b-2* hsa-miR-19a*
    SwitchGear 3'UTR luciferase reporter plasmidALDOC 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ALDOC

    Additional mRNA sequence: 

    AF054987.1 AK293453.1 AK293623.1 AK293693.1 AK294091.1 AK294157.1 AK296039.1 AK296053.1 
    AK312281.1 BC003613.2 BC065565.1 BC103760.1 BC106925.1 BC106926.1 BT007006.1 CR541862.1 
    CR541881.1 

    20 DOTS entries:

    DT.454051  DT.95276593  DT.100693364  DT.100882639  DT.91694292  DT.100882646  DT.120959743  DT.100882642 
    DT.102843805  DT.100882649  DT.100882626  DT.120959667  DT.100882625  DT.120959684  DT.120959745  DT.120959746 
    DT.95276567  DT.95276575  DT.99937107  DT.120959815 

    24/680 AceView cDNA sequences (see all 680):

    CR610835 CR607349 BQ636093 BP347370 CR601362 BM551873 BP347505 F11620 
    BQ639326 BQ772987 BX333597 CB154585 F09275 AA594379 CR622257 BX422889 
    BP381328 BQ879022 BG818262 CB146084 AA317368 AU142755 BM809937 BQ639039 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ALDOC (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^ 10 ^ 11
    SP1:                                                                                                                                    
    SP2:              -                                                                                                                     
    SP3:                                                                                                                                    
    SP4:                                                                    -     -     -     -                                             
    SP5:              -                             -     -                                                                                 


    ECgene alternative splicing isoforms for ALDOC

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ALDOC expression in normal human tissues (normalized intensities)      ALDOC embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTTGAGTAC
    ALDOC Expression
    About this image


    ALDOC expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/8 selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 32 entries
             Thalamus
             Globus Pallidus   
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Rhombencephalon
             spinal cord/lateral wall/ventricular layer   
     
     Spinal Cord (Nervous System)    fully expand to see all 3 entries
             Dorsal Root Ganglion   
     
     Nose (Sensory Organs)
             sensory organ/nose/nasal cavity   
     
     Eye (Sensory Organs)
             Retina

    See ALDOC Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ALDOC

    SOURCE GeneReport for Unigene cluster: Hs.155247
        SABiosciences Expression via Pathway-Focused PCR Array including ALDOC: 
              Glucose Metabolism in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ALDOC gene from 8/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Aldoc1 , 5 aldolase C, fructose-bisphosphate1, 5 90.54(n)1
    97.8(a)1
      11 (46.74 cM)5
    116761  NM_009657.31  NP_033787.21 
     783229685 
    chicken
    (Gallus gallus)
    Aves ALDOC1 aldolase C, fructose-bisphosphate 81.5(n)
    91.76(a)
      395492  NM_001206496.1  NP_001193425.1 
    lizard
    (Anolis carolinensis)
    Reptilia ALDOC6
    Fructose-bisphosphate aldolase
    87(a)
    1 ↔ 1
    GL343470.1(443920-451511)
    African clawed frog
    (Xenopus laevis)
    Amphibia aldoc-prov2 aldolase C, fructose-bisphosphate 78.98(n)    BC045218.1 
    zebrafish
    (Danio rerio)
    Actinopterygii AF533647.12   -- 77.5(n)   369193  AF533647.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ald3 glycolysis fructose-bisphosphate
    aldolase
    70(a)
    (best of 2)
      3 97A6   --
    worm
    (Caenorhabditis elegans)
    Secernentea T05D4.13 Fructose-bisphosphate aldolase class-I 65(a)
    (best of 3)
      III(13634767-13636203)   --
    rice
    (Oryza sativa)
    Liliopsida Os08g01206001 hypothetical protein 58.05(n)
    57.3(a)
      4344545  NM_001067415.1  NP_001060880.1 


    ENSEMBL Gene Tree for ALDOC (if available)
    TreeFam Gene Tree for ALDOC (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ALDOC gene
    ALDOA2  ALDOB2  
    2 SIMAP similar genes for ALDOC using alignment to 7 protein entries:     ALDOC_HUMAN (see all proteins):
    ALDOA    ALDOB

    ALDOC for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/104 SNPs in ALDOC are shown (see all 104)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1512910131,2
    C,F--26900908(+) GTTGAA/GTGATG 2 L F mis11Minor allele frequency- G:0.00NA 4552
    rs2018515411,2
    --26901002(+) TTTCCA/GGGATA 1 -- int10--------
    rs342366361,2
    C,H--26901056(+) AGGGAT/CAGGAG 1 -- int13Minor allele frequency- C:0.01NS NA 176
    rs749022881,2
    C,F--26901104(+) GGCACA/TGTGCG 2 T syn12Minor allele frequency- T:0.00WA NA 4646
    rs1456656881,2
    C,F--26901111(+) TGCGAC/TGCAGG 2 H R mis12Minor allele frequency- T:0.00NA EU 5375
    rs2004536521,2
    --26901169(+) ACAGGA/CATGGC 2 A S mis10--------
    rs22284191,2
    C,F--26901194(-) CTCAAG/ACCCAA 2 /K syn14Minor allele frequency- A:0.01MN NA WA 4812
    rs1380766341,2
    C,F--26901197(+) GGCTTG/AAGCAG 2 /L syn12Minor allele frequency- A:0.00NA EU 5857
    rs1812897841,2
    C--26901202(+) GAGCAA/GGGTCC 2 L syn10--------
    rs1495198561,2
    C,F--26901242(+) GCCTTG/ATACAC 2 /Y syn11Minor allele frequency- A:0.00NA 4548

    HapMap Linkage Disequilibrium report for ALDOC (26900133 - 26904282 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for ALDOC: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ALDOC
    DNA2.0 Custom Variant and Variant Library Synthesis for ALDOC

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 103870    OMIM disorders: --

    13 diseases for ALDOC:    About MalaCards
    eumycotic mycetoma    mycetoma    giardiasis    borna disease
    hypogonadism    down syndrome    schizophrenia    hypoxia
    neuroblastoma    obesity    hypertension    alzheimer's disease
    neuronitis

    1 disease from the University of Copenhagen DISEASES database for ALDOC:
    Eumycotic mycetoma

    ALDOC for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Export disorders for ALDOC gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ALDOC gene, integrated from 9 sources (see all 52):
    (articles sorted by number of sources associating them with ALDOC)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure of human brain fructose 1,6-(bis)phosphate aldolase: linking isozyme structure with function. (PubMed id 15537755)1, 2 Arakaki T.L.... Allen K.N. (2004)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Phospholipase D2 directly interacts with aldolase via Its PH domain. (PubMed id 11876650)1, 2 Kim J.H....Ryu S.H. (2002)
    4. Interaction between aldolase and vacuolar H+-ATPase: evidence for direct coupling of glycolysis to the ATP-hydrolyzing proton pump. (PubMed id 11399750)1, 2 Lu M.... Gluck S.L. (2001)
    5. Characterization of the transcription-initiation site and of the promoter region within the 5' flanking region of the human aldolase C gene. (PubMed id 2209624)1, 2 Buono P.... Salvatore F. (1990)
    6. The complete nucleotide sequence of the gene coding for the human aldolase C. (PubMed id 3267224)1, 2 Buono P.... Salvatore F. (1988)
    7. The complete amino acid sequence of the human aldolase C isozyme derived from genomic clones. (PubMed id 3105602)1, 2 Rottmann W.H.... Tolan D.R. (1987)
    8. Proteome analysis of schizophrenia patients Wernicke's area reveals an energy metabolism dysregulation. (PubMed id 19405953)1, 9 Martins-de-Souza D....Dias-Neto E. (2009)
    9. Bcl2-associated Athanogene 3 Interactome Analysis Reve als a New Role in Modulating Proteasome Activity. (PubMed id 23824909)1 Chen Y....Ge F. (2013)
    10. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 230 HGNC: 418 AceView: ALDOC Ensembl:ENSG00000109107 euGenes: HUgn230
    ECgene: ALDOC Kegg: 230 H-InvDB: ALDOC

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ALDOC Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ALDOC gene:
    Search GeneIP for patents involving ALDOC

    Licensable Technologies for ALDOC gene:
    Weizmann Institute:Diagnosis and Treatment of Alzheimer Directed Against Aldolase
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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