Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ALDOC Gene

Aliases for ALDOC Gene

  • Aldolase, Fructose-Bisphosphate C 2 3 5
  • Aldolase C, Fructose-Bisphosphate 2 3
  • Brain-Type Aldolase 3 4
  • EC 4.1.2.13 4 61
  • ALDC 3 4
  • Fructose-1,6-Biphosphate Triosephosphate Lyase 3
  • Fructose-Bisphosphate Aldolase C 3
  • Fructoaldolase C 3
  • Aldolase 3 3

External Ids for ALDOC Gene

Previous GeneCards Identifiers for ALDOC Gene

  • GC17M026745
  • GC17M028799
  • GC17M027045
  • GC17M023924
  • GC17M026900
  • GC17M023109
  • GC17M028576
  • GC17M028578
  • GC17M028669
  • GC17M028763

Summaries for ALDOC Gene

Entrez Gene Summary for ALDOC Gene

  • This gene encodes a member of the class I fructose-biphosphate aldolase gene family. Expressed specifically in the hippocampus and Purkinje cells of the brain, the encoded protein is a glycolytic enzyme that catalyzes the reversible aldol cleavage of fructose-1,6-biphosphate and fructose 1-phosphate to dihydroxyacetone phosphate and either glyceraldehyde-3-phosphate or glyceraldehyde, respectively. [provided by RefSeq, Jul 2008]

GeneCards Summary for ALDOC Gene

ALDOC (Aldolase, Fructose-Bisphosphate C) is a Protein Coding gene. Among its related pathways are Citrate cycle (TCA cycle) and Fructose metabolism. GO annotations related to this gene include cytoskeletal protein binding and fructose-bisphosphate aldolase activity. An important paralog of this gene is ALDOA.

Gene Wiki entry for ALDOC Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ALDOC Gene

Genomics for ALDOC Gene

Regulatory Elements for ALDOC Gene

Enhancers for ALDOC Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G028546 1 ENCODE 11.7 +26.9 26855 7.7 HDGF PKNOX1 AGO1 ARID4B SIN3A GLI4 ZNF48 YY1 GLIS2 ZNF143 ENSG00000264577 NUFIP2 ENSG00000264044 LOC101927018 PHF12 ENSG00000265205 PIGS SDF2 FOXN1 ALDOC
GH17G028576 1.1 ENCODE 0.7 +0.1 63 1.6 HDGF PKNOX1 MLX ARID4B DMAP1 YY1 SLC30A9 ZNF143 ZNF207 SP3 ENSG00000264577 SDF2 TMEM199 NUFIP2 SPAG5-AS1 SGK494 RPL23A KIAA0100 PHF12 UNC119
GH17G028581 0.4 Ensembl 0.7 -4.2 -4238 0.6 NFIC ZBTB40 SGK494 UNC119 KIAA0100 ALDOC SPAG5-AS1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ALDOC on UCSC Golden Path with GeneCards custom track

Promoters for ALDOC Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000092744 464 401 HDGF PKNOX1 ATF1 ARID4B DMAP1 ZNF48 YY1 GLIS2 ZNF143 ZNF207

Genomic Location for ALDOC Gene

Chromosome:
17
Start:
28,573,115 bp from pter
End:
28,577,264 bp from pter
Size:
4,150 bases
Orientation:
Minus strand

Genomic View for ALDOC Gene

Genes around ALDOC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ALDOC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ALDOC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ALDOC Gene

Proteins for ALDOC Gene

  • Protein details for ALDOC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P09972-ALDOC_HUMAN
    Recommended name:
    Fructose-bisphosphate aldolase C
    Protein Accession:
    P09972
    Secondary Accessions:
    • B2R5R3
    • Q3SYL3
    • Q6FH94
    • Q6P0L5

    Protein attributes for ALDOC Gene

    Size:
    364 amino acids
    Molecular mass:
    39456 Da
    Quaternary structure:
    • Homotetramer. Interacts with ATP6V1E1. May interact with PLD2.
    Miscellaneous:
    • In vertebrates, three forms of this ubiquitous glycolytic enzyme are found, aldolase A in muscle, aldolase B in liver and aldolase C in brain.
    SequenceCaution:
    • Sequence=AAI03761.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ALDOC Gene

neXtProt entry for ALDOC Gene

Selected DME Specific Peptides for ALDOC Gene

P09972:
  • KCIGGVIFFHETLYQ
  • FSYGRALQAS
  • GIKVDKG
  • GKYEGSG
  • KRAEVNGLAA
  • LARYASI
  • PDGDHDL
  • DGGAAAQSLY
  • AWRGQRDNA
  • VLAAVYKAL
  • YKALSDHHV
  • GILAADES
  • AATEEFIKRAE
  • GVTFLSGG
  • GIVVGIK
  • LEGTLLKPNMVT
  • RCAQYKKDG
  • PWALTFS
  • LAILENAN
  • CPLPRPW
  • VPIVEPE
  • DHHVYLEGTLLKPNM
  • EEIAMATVTALRRTVPPAV
  • EENRRLYRQ
  • ENTEENRR
  • LSGGQSE
  • FHETLYQK
  • DFAKWRCVLKI
  • GETTTQGLDGL
  • ENANVLARYA
  • CQYVTEKVLAA

Post-translational modifications for ALDOC Gene

  • Ubiquitination at Lys28, Lys42, posLast=111111, and posLast=330330
  • Modification sites at PhosphoSitePlus

Antibody Products

Domains & Families for ALDOC Gene

Protein Domains for ALDOC Gene

Graphical View of Domain Structure for InterPro Entry

P09972

UniProtKB/Swiss-Prot:

ALDOC_HUMAN :
  • Belongs to the class I fructose-bisphosphate aldolase family.
Family:
  • Belongs to the class I fructose-bisphosphate aldolase family.
genes like me logo Genes that share domains with ALDOC: view

No data available for Gene Families for ALDOC Gene

Function for ALDOC Gene

Molecular function for ALDOC Gene

GENATLAS Biochemistry:
aldolase C,fructose-bisphosphate,160kDa,fructose metabolism,energy pathway,more affinity for F-1-P than for F-1,6-P
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=10.7 uM for fructose 1,6-bisphosphate {ECO:0000269 PubMed:15537755}; KM=16 mM for fructose 1-phosphate {ECO:0000269 PubMed:15537755};
UniProtKB/Swiss-Prot CatalyticActivity:
D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Enzyme Numbers (IUBMB) for ALDOC Gene

Gene Ontology (GO) - Molecular Function for ALDOC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004332 fructose-bisphosphate aldolase activity IDA,IEA 9244396
GO:0005515 protein binding IPI 11399750
GO:0008092 cytoskeletal protein binding IDA 9244396
GO:0016829 lyase activity IEA --
genes like me logo Genes that share ontologies with ALDOC: view
genes like me logo Genes that share phenotypes with ALDOC: view

Animal Models for ALDOC Gene

MGI Knock Outs for ALDOC:

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ALDOC Gene

Localization for ALDOC Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ALDOC gene
Compartment Confidence
extracellular 5
cytosol 5
cytoskeleton 4
mitochondrion 3
nucleus 3
lysosome 1

Gene Ontology (GO) - Cellular Components for ALDOC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IC 9244396
GO:0034774 secretory granule lumen TAS --
genes like me logo Genes that share ontologies with ALDOC: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ALDOC Gene

Pathways & Interactions for ALDOC Gene

genes like me logo Genes that share pathways with ALDOC: view

UniProtKB/Swiss-Prot P09972-ALDOC_HUMAN

  • Pathway: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.

Gene Ontology (GO) - Biological Process for ALDOC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006000 fructose metabolic process TAS 3105602
GO:0006094 gluconeogenesis TAS --
GO:0006096 glycolytic process IEA --
GO:0030388 fructose 1,6-bisphosphate metabolic process IDA 9244396
GO:0030855 epithelial cell differentiation IEP 21492153
genes like me logo Genes that share ontologies with ALDOC: view

No data available for SIGNOR curated interactions for ALDOC Gene

Drugs & Compounds for ALDOC Gene

(3) Drugs for ALDOC Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved Pharma 2296
Glyceraldehyde-3-Phosphate Experimental Pharma 0
Dihydroxyacetone phosphate Investigational Pharma 0

(6) Additional Compounds for ALDOC Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
beta-D-Fructose 1,6-bisphosphate
D-Erythrose 4-phosphate
  • D-Erythrose 4-phosphate
  • D-Erythrose 4-PO4
  • D-Erythrose-4-P
  • D-Erythrose-4-phosphate
  • Erythrose 4-phosphate
585-18-2
Fructose 1,6-bisphosphate
  • D-Fructose 1,6-biphosphate
  • D-Fructose 1,6-bis(dihydrogen phosphate)
  • D-Fructose 1,6-bisphosphate
  • D-Fructose 1,6-diphosphate
  • D-Fructose-1,6-bisphosphate
488-69-7
fructose 1-phosphate
  • D-Fructose 1-phosphate
  • D-Fructose-1-P
  • D-Fructose-1-phosphate
  • Fructose 1-phosphate
  • Fructose-1-P
15978-08-2
glyceraldehyde
  • (+/-)-2,3-dihydroxy-Propanal
  • (+/-)-Glyceraldehyde
  • 2,3-Dihydroxypropanal
  • 2,3-Dihydroxypropionaldehyde
  • alpha,beta-Dihydroxypropionaldehyde
56-82-6
genes like me logo Genes that share compounds with ALDOC: view

Transcripts for ALDOC Gene

Unigene Clusters for ALDOC Gene

Aldolase C, fructose-bisphosphate:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ALDOC Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^ 10 ^ 11
SP1:
SP2: -
SP3:
SP4: - - - -
SP5: - - -
SP6: -

Relevant External Links for ALDOC Gene

GeneLoc Exon Structure for
ALDOC
ECgene alternative splicing isoforms for
ALDOC

Expression for ALDOC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ALDOC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ALDOC Gene

This gene is overexpressed in Brain - Cerebellum (x4.9).

Protein differential expression in normal tissues from HIPED for ALDOC Gene

This gene is overexpressed in Retina (15.5), Frontal cortex (11.9), Spinal cord (7.2), and Brain (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ALDOC Gene



Protein tissue co-expression partners for ALDOC Gene

NURSA nuclear receptor signaling pathways regulating expression of ALDOC Gene:

ALDOC

SOURCE GeneReport for Unigene cluster for ALDOC Gene:

Hs.155247

Evidence on tissue expression from TISSUES for ALDOC Gene

  • Nervous system(5)
  • Eye(4.8)
  • Liver(4.6)
  • Intestine(4.3)
  • Heart(3.9)
  • Muscle(2.9)
genes like me logo Genes that share expression patterns with ALDOC: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ALDOC Gene

Orthologs for ALDOC Gene

This gene was present in the common ancestor of animals.

Orthologs for ALDOC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ALDOC 35 34
  • 99.54 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ALDOC 35
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ALDOC 34 35
  • 93.32 (n)
cow
(Bos Taurus)
Mammalia ALDOC 34 35
  • 92.67 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ALDOC 35
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Aldoc 34 16 35
  • 90.54 (n)
rat
(Rattus norvegicus)
Mammalia Aldoc 34
  • 90.45 (n)
chicken
(Gallus gallus)
Aves ALDOC 34 35
  • 81.5 (n)
lizard
(Anolis carolinensis)
Reptilia ALDOC 35
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia aldoc 34
  • 77.29 (n)
Str.3134 34
African clawed frog
(Xenopus laevis)
Amphibia aldoc-prov 34
zebrafish
(Danio rerio)
Actinopterygii aldoca 35
  • 79 (a)
OneToOne
aldocb 34
  • 76.49 (n)
-- 34
fruit fly
(Drosophila melanogaster)
Insecta Ald 36 35
  • 70 (a)
CG5432 36 35
  • 58 (a)
worm
(Caenorhabditis elegans)
Secernentea T05D4.1 36
  • 65 (a)
F01F1.12b 36
  • 62 (a)
F01F1.12a 36
  • 61 (a)
aldo-2 35
  • 61 (a)
ManyToMany
aldo-1 34 35
  • 60.41 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11039 35
  • 70 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5322 34
Species where no ortholog for ALDOC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ALDOC Gene

ENSEMBL:
Gene Tree for ALDOC (if available)
TreeFam:
Gene Tree for ALDOC (if available)

Paralogs for ALDOC Gene

Paralogs for ALDOC Gene

(2) SIMAP similar genes for ALDOC Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with ALDOC: view

Variants for ALDOC Gene

Sequence variations from dbSNP and Humsavar for ALDOC Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1001131257 -- 28,576,786(+) CCCGC(C/T)TTGCC intron-variant
rs1001161195 -- 28,576,305(+) AATAG(A/G)AAGCA intron-variant
rs1001293858 -- 28,577,162(+) GGATT(-/A)AAGCT downstream-variant-500B, upstream-variant-2KB
rs1001310555 -- 28,577,035(+) GTGAG(C/T)GCCCC upstream-variant-2KB
rs1001502500 -- 28,576,485(+) GAGAG(G/T)ACCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ALDOC Gene

Variant ID Type Subtype PubMed ID
nsv1064087 CNV gain 25217958

Variation tolerance for ALDOC Gene

Residual Variation Intolerance Score: 33.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.86; 34.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ALDOC Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ALDOC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ALDOC Gene

Disorders for ALDOC Gene

Relevant External Links for ALDOC

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ALDOC

No disorders were found for ALDOC Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ALDOC Gene

Publications for ALDOC Gene

  1. Proteome analysis of schizophrenia patients Wernicke's area reveals an energy metabolism dysregulation. (PMID: 19405953) Martins-de-Souza D. … Dias-Neto E. (BMC Psychiatry 2009) 3 22 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Structure of human brain fructose 1,6-(bis)phosphate aldolase: linking isozyme structure with function. (PMID: 15537755) Arakaki T.L. … Allen K.N. (Protein Sci. 2004) 3 4 64
  4. Phospholipase D2 directly interacts with aldolase via its PH domain. (PMID: 11876650) Kim J.H. … Ryu S.H. (Biochemistry 2002) 3 4 64
  5. Interaction between aldolase and vacuolar H+-ATPase: evidence for direct coupling of glycolysis to the ATP-hydrolyzing proton pump. (PMID: 11399750) Lu M. … Gluck S.L. (J. Biol. Chem. 2001) 3 4 64

Products for ALDOC Gene

Sources for ALDOC Gene

Content
Loading form....