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Aliases for ALDOC Gene

Aliases for ALDOC Gene

  • Aldolase, Fructose-Bisphosphate C 2 3 5
  • Aldolase C, Fructose-Bisphosphate 2 3
  • Brain-Type Aldolase 3 4
  • EC 4.1.2.13 4 63
  • ALDC 3 4
  • Fructose-1,6-Biphosphate Triosephosphate Lyase 3
  • Fructoaldolase C 3
  • Aldolase 3 3

External Ids for ALDOC Gene

Previous GeneCards Identifiers for ALDOC Gene

  • GC17M026745
  • GC17M028799
  • GC17M027045
  • GC17M023924
  • GC17M026900
  • GC17M023109
  • GC17M028576

Summaries for ALDOC Gene

Entrez Gene Summary for ALDOC Gene

  • This gene encodes a member of the class I fructose-biphosphate aldolase gene family. Expressed specifically in the hippocampus and Purkinje cells of the brain, the encoded protein is a glycolytic enzyme that catalyzes the reversible aldol cleavage of fructose-1,6-biphosphate and fructose 1-phosphate to dihydroxyacetone phosphate and either glyceraldehyde-3-phosphate or glyceraldehyde, respectively. [provided by RefSeq, Jul 2008]

GeneCards Summary for ALDOC Gene

ALDOC (Aldolase, Fructose-Bisphosphate C) is a Protein Coding gene. Diseases associated with ALDOC include eumycotic mycetoma. Among its related pathways are Metabolism and Glycosaminoglycan metabolism. GO annotations related to this gene include cytoskeletal protein binding and fructose-bisphosphate aldolase activity. An important paralog of this gene is ALDOB.

Gene Wiki entry for ALDOC Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ALDOC Gene

Genomics for ALDOC Gene

Regulatory Elements for ALDOC Gene

Promoters for ALDOC Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ALDOC on UCSC Golden Path with GeneCards custom track

Genomic Location for ALDOC Gene

Chromosome:
17
Start:
28,573,115 bp from pter
End:
28,577,264 bp from pter
Size:
4,150 bases
Orientation:
Minus strand

Genomic View for ALDOC Gene

Genes around ALDOC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ALDOC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ALDOC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ALDOC Gene

Proteins for ALDOC Gene

  • Protein details for ALDOC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P09972-ALDOC_HUMAN
    Recommended name:
    Fructose-bisphosphate aldolase C
    Protein Accession:
    P09972
    Secondary Accessions:
    • B2R5R3
    • Q3SYL3
    • Q6FH94
    • Q6P0L5

    Protein attributes for ALDOC Gene

    Size:
    364 amino acids
    Molecular mass:
    39456 Da
    Quaternary structure:
    • Homotetramer. Interacts with ATP6V1E1. May interact with PLD2.
    Miscellaneous:
    • In vertebrates, three forms of this ubiquitous glycolytic enzyme are found, aldolase A in muscle, aldolase B in liver and aldolase C in brain.
    SequenceCaution:
    • Sequence=AAI03761.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ALDOC Gene

neXtProt entry for ALDOC Gene

Proteomics data for ALDOC Gene at MOPED

Post-translational modifications for ALDOC Gene

  • Ubiquitination at Lys 28, Lys 42, Lys 111, and Lys 330
  • Modification sites at PhosphoSitePlus

Antibody Products

Domains & Families for ALDOC Gene

Protein Domains for ALDOC Gene

Graphical View of Domain Structure for InterPro Entry

P09972

UniProtKB/Swiss-Prot:

ALDOC_HUMAN :
  • Belongs to the class I fructose-bisphosphate aldolase family.
Family:
  • Belongs to the class I fructose-bisphosphate aldolase family.
genes like me logo Genes that share domains with ALDOC: view

No data available for Gene Families for ALDOC Gene

Function for ALDOC Gene

Molecular function for ALDOC Gene

GENATLAS Biochemistry:
aldolase C,fructose-bisphosphate,160kDa,fructose metabolism,energy pathway,more affinity for F-1-P than for F-1,6-P
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=10.7 uM for fructose 1,6-bisphosphate {ECO:0000269 PubMed:15537755}; KM=16 mM for fructose 1-phosphate {ECO:0000269 PubMed:15537755};
UniProtKB/Swiss-Prot CatalyticActivity:
D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Enzyme Numbers (IUBMB) for ALDOC Gene

Gene Ontology (GO) - Molecular Function for ALDOC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004332 fructose-bisphosphate aldolase activity IDA 9244396
genes like me logo Genes that share ontologies with ALDOC: view
genes like me logo Genes that share phenotypes with ALDOC: view

Animal Model Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ALDOC Gene

Localization for ALDOC Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ALDOC Gene COMPARTMENTS Subcellular localization image for ALDOC gene
Compartment Confidence
cytosol 5
extracellular 5
cytoskeleton 4
mitochondrion 3
nucleus 3
chloroplast 2
lysosome 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for ALDOC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005856 cytoskeleton IC 9244396
genes like me logo Genes that share ontologies with ALDOC: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ALDOC Gene

Pathways & Interactions for ALDOC Gene

genes like me logo Genes that share pathways with ALDOC: view

UniProtKB/Swiss-Prot P09972-ALDOC_HUMAN

  • Pathway: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.

Gene Ontology (GO) - Biological Process for ALDOC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006000 fructose metabolic process TAS 3105602
GO:0006094 gluconeogenesis TAS --
GO:0030855 epithelial cell differentiation IEP 21492153
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with ALDOC: view

No data available for SIGNOR curated interactions for ALDOC Gene

Drugs & Compounds for ALDOC Gene

(2) Drugs for ALDOC Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved Pharma 1477
Glyceraldehyde-3-Phosphate Experimental Pharma 0

(7) Additional Compounds for ALDOC Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
beta-D-Fructose 1,6-bisphosphate
D-Erythrose 4-phosphate
  • D-Erythrose 4-phosphate
  • D-Erythrose 4-PO4
  • D-Erythrose-4-P
  • D-Erythrose-4-phosphate
  • Erythrose 4-phosphate
585-18-2
Dihydroxyacetone phosphate
  • 1,3-Dihydroxy-2-Propanone mono(dihydrogen phosphate)
  • 1,3-Dihydroxy-2-propanone phosphate
  • 1,3-Dihydroxyacetone 1-phosphate
  • 1-Hydroxy-3-(phosphonooxy)-2-Propanone
  • 1-Hydroxy-3-(phosphonooxy)acetone
57-04-5
Fructose 1,6-bisphosphate
  • D-Fructose 1,6-biphosphate
  • D-Fructose 1,6-bis(dihydrogen phosphate)
  • D-Fructose 1,6-bisphosphate
  • D-Fructose 1,6-diphosphate
  • D-Fructose-1,6-bisphosphate
488-69-7
fructose 1-phosphate
  • D-Fructose 1-phosphate
  • D-Fructose-1-P
  • D-Fructose-1-phosphate
  • Fructose 1-phosphate
  • Fructose-1-P
15978-08-2
genes like me logo Genes that share compounds with ALDOC: view

Transcripts for ALDOC Gene

Unigene Clusters for ALDOC Gene

Aldolase C, fructose-bisphosphate:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ALDOC Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^ 10 ^ 11
SP1:
SP2: -
SP3:
SP4: - - - -
SP5: - - -
SP6: -

Relevant External Links for ALDOC Gene

GeneLoc Exon Structure for
ALDOC
ECgene alternative splicing isoforms for
ALDOC

Expression for ALDOC Gene

mRNA expression in normal human tissues for ALDOC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ALDOC Gene

This gene is overexpressed in Brain - Cerebellum (x4.9).

Protein differential expression in normal tissues from HIPED for ALDOC Gene

This gene is overexpressed in Retina (15.5), Frontal cortex (11.9), Spinal cord (7.2), and Brain (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ALDOC Gene



SOURCE GeneReport for Unigene cluster for ALDOC Gene Hs.155247

genes like me logo Genes that share expression patterns with ALDOC: view

Protein tissue co-expression partners for ALDOC Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ALDOC Gene

Orthologs for ALDOC Gene

This gene was present in the common ancestor of animals.

Orthologs for ALDOC Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ALDOC 35
  • 92.67 (n)
  • 98.63 (a)
ALDOC 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ALDOC 35
  • 93.32 (n)
  • 98.63 (a)
ALDOC 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Aldoc 35
  • 90.54 (n)
  • 97.8 (a)
Aldoc 16
Aldoc 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ALDOC 35
  • 99.54 (n)
  • 99.18 (a)
ALDOC 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Aldoc 35
  • 90.45 (n)
  • 96.97 (a)
oppossum
(Monodelphis domestica)
Mammalia ALDOC 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ALDOC 36
  • 91 (a)
OneToOne
chicken
(Gallus gallus)
Aves ALDOC 35
  • 81.5 (n)
  • 91.76 (a)
ALDOC 36
  • 92 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ALDOC 36
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia aldoc 35
  • 77.29 (n)
  • 86.26 (a)
Str.3134 35
African clawed frog
(Xenopus laevis)
Amphibia aldoc-prov 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
aldocb 35
  • 76.49 (n)
  • 84.85 (a)
aldoca 36
  • 79 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Ald 37
  • 70 (a)
CG5432 37
  • 58 (a)
Ald 36
  • 67 (a)
ManyToMany
CG5432 36
  • 57 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea F01F1.12a 37
  • 61 (a)
F01F1.12b 37
  • 62 (a)
T05D4.1 37
  • 65 (a)
aldo-1 35
  • 60.41 (n)
  • 65.27 (a)
aldo-1 36
  • 64 (a)
ManyToMany
aldo-2 36
  • 61 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5322 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11039 36
  • 70 (a)
OneToMany
Species with no ortholog for ALDOC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ALDOC Gene

ENSEMBL:
Gene Tree for ALDOC (if available)
TreeFam:
Gene Tree for ALDOC (if available)

Paralogs for ALDOC Gene

Paralogs for ALDOC Gene

(2) SIMAP similar genes for ALDOC Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with ALDOC: view

Variants for ALDOC Gene

Sequence variations from dbSNP and Humsavar for ALDOC Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs2228419 -- 28,574,176(-) CTCAA(A/G/T)CCCAA reference, synonymous-codon
rs2229541 -- 28,574,846(-) GATGG(A/G)CTCTC reference, synonymous-codon
rs3095126 -- 28,576,779(-) CGGGA(C/G)CCACT intron-variant
rs11559066 -- 28,575,135(-) ATCGT(C/T)GTGGG reference, synonymous-codon
rs34165301 -- 28,575,827(+) CTTCT(A/G)ATAAA intron-variant

Variation tolerance for ALDOC Gene

Residual Variation Intolerance Score: 33.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.86; 34.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ALDOC Gene

HapMap Linkage Disequilibrium report
ALDOC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ALDOC Gene

Disorders for ALDOC Gene

MalaCards: The human disease database

(1) MalaCards diseases for ALDOC Gene - From: DISEASES

Disorder Aliases PubMed IDs
eumycotic mycetoma
  • eumycetoma
- elite association - COSMIC cancer census association via MalaCards
Search ALDOC in MalaCards View complete list of genes associated with diseases

Relevant External Links for ALDOC

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ALDOC
genes like me logo Genes that share disorders with ALDOC: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ALDOC Gene

Publications for ALDOC Gene

  1. Structure of human brain fructose 1,6-(bis)phosphate aldolase: linking isozyme structure with function. (PMID: 15537755) Arakaki T.L. … Allen K.N. (Protein Sci. 2004) 3 4 67
  2. Proteome analysis of schizophrenia patients Wernicke's area reveals an energy metabolism dysregulation. (PMID: 19405953) Martins-de-Souza D. … Dias-Neto E. (BMC Psychiatry 2009) 3 23
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for ALDOC Gene

Sources for ALDOC Gene

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