ALDOB Gene
protein-coding GIFtS : 67 GCID: GC09 M104182
aldolase B, fructose-bisphosphate
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Aliasesfor ALDOB gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Aldolase B, Fructose-Bisphosphate 1 2 ALDO22 Liver-Type Aldolase2 3 Aldolase 22 ALDB2 3 Aldolase B, Fructose-Bisphosphatase2 EC 4.1.2.133 8 Fructose-Bisphosphate Aldolase B2
Export aliases for ALDOB gene to outside databases Previous GC identifers: GC09M094983 GC09M095927 GC09M097641 GC09M099563 GC09M101263 GC09M103222 GC09M073782
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Summariesfor ALDOB gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for ALDOB : Fructose-1,6-bisphosphate aldolase (EC 4.1.2.13) is a tetrameric glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Vertebrates have 3 aldolase isozymes which are distinguished by their electrophoretic and catalytic properties. Differences indicate that aldolases A, B, and C are distinct proteins, the products of a family of related 'housekeeping' genes exhibiting developmentally regulated expression of the different isozymes. The developing embryo produces aldolase A, which is produced in even greater amounts in adult muscle where it can be as much as 5% of total cellular protein. In adult liver, kidney and intestine, aldolase A expression is repressed and aldolase B is produced. In brain and other nervous tissue, aldolase A and C are expressed about equally. There is a high degree of homology between aldolase A and C. Defects in ALDOB cause hereditary fructose intolerance. (provided by RefSeq, Dec 2008) Gene Wiki entry for ALDOB (Aldolase B)
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Genomic Viewsfor ALDOB gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000009.11 NC_018920.1 NT_008470.19 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the ALDOB gene promoter:AML1a STAT5A Other transcription factors Search SABiosciences Chromatin IP Primers for ALDOB Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ALDOB
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 9q21.3-q22.2 Ensembl cytogenetic band: 9q31.1 HGNC cytogenetic band: 9q21.3-q22.2 ALDOB Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 9 GeneLoc Exon Structure
GeneLoc location for GC09M104182: view genomic region
(about GC identifiers )
Start: 104,182,842 bp from pter End:
104,198,105 bp from pter
Size: 15,264 bases Orientation:
minus strand
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Proteinsfor ALDOB gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: ALDOB_HUMAN, P05062 See
protein sequence )Recommended Name: Size : 364 amino acids; 39473 DaSubunit : HomotetramerMiscellaneous : In vertebrates, three forms of this ubiquitous glycolytic enzyme are found, aldolase A in muscle,aldolase B in liver and aldolase C in brain
3 PDB 3D structures from :1QO5 (3D) 1XDL (3D) 1XDM (3D) Secondary accessions : Q13741 Q13742 Q5T7D6Explore the universe of human proteins at neXtProt for ALDOB: NX_P05062 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_P05062 4/24 DME Specific Peptides for ALDOB (P05062 ) (see all 24 )ALDOB Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins: NP_000026.2 ENSEMBL proteins: ENSP00000363988 ENSP00000363986 Reactome Protein details: P05062 Human Recombinant Protein Products: Gene Ontology (GO): 5/11 cellular component terms (GO ID links to tree view) (see all 11 ): About this table
About GeneDecksing ALDOB Antibody Products: Assay Products for ALDOB:
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Protein
Domains /for ALDOB gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section About GeneDecksing 2 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry P05062 ProtoNet protein and cluster: P05062
1 Blocks protein family : IPB000741 UniProtKB/Swiss-Prot: ALDOB_HUMAN, P05062 Similarity : Belongs to the class I fructose-bisphosphate aldolase family
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Functionfor ALDOB gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: ALDOB_HUMAN, P05062 Catalytic activity : D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphateBiophysicochemical properties : Kinetic parameters: KM=1.6 uM for fructose 1,6-bisphosphate; KM=2.3 mM for fructose1-phosphate;
Genatlas biochemistry entry for ALDOB aldolase B,fructose-bisphosphate,homotetramer,fructose metabolism,induced after feeding a carbohydrate diet,energy pathway,same affinity for F-1-P and F-1,6-P Enzyme Number (IUBMB): EC 4.1.2.13 1 2 Clone Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 3 )human mouse rat OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: ALDOB (NM_000035 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ALDOB Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ALDOB
In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALDOB
Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7 ): About this table
About GeneDecksing 3 GenomeRNAi human phenotypes for ALDOB :
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Pathways & Interactionsfor ALDOB gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways - 5/9 super-pathways (see all 9 ) About this table See pathways by source Super-pathway contained gene-specific pathways 1 Glycolysis and gluconeogenesis (short map) 2 Glucose metabolism 3 Fructose catabolism 4 Metabolism 5 gluconeogenesis I
Pathway sources See GeneCards unified pathways Show all pathways 1 1 5/6 (see all 6 ) 5/6 (see all 6 )4 (Kegg details for ALDOB) :UniProtKB/Swiss-Prot: ALDOB_HUMAN, P05062 Pathway : Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose:step 4/4 About GeneDecksing Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ALDOB STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/56 Interacting proteins for ALDOB (P05062 1 , 3 ENSP00000363988 4 via UniProtKB, MINT, STRING , and/or I2D (see all 56 )
Interactant Interaction Details GeneCard External ID(s) BBS2 Q9BXC9 1 , 3 ENSP00000245157 4 EBI-1045507,EBI-748297 I2D:
score=1 STRING: ENSP00000245157 BBS1 Q8NFJ9 1 , 3 EBI-1045507,EBI-1805484 I2D:
score=1 BBS4 Q96RK4 1 , 3 ENSP00000268057 4 EBI-1045507,EBI-1805814 I2D:
score=1 STRING: ENSP00000268057 BBS7 Q8IWZ6 1 , 3 ENSP00000264499 4 EBI-1045507,EBI-1806001 I2D:
score=1 STRING: ENSP00000264499 ATP6V1E1 P36543 3 ENSP00000253413 4 I2D:
score=2 STRING: ENSP00000253413
About this table Gene Ontology (GO): 5/28 biological process terms (GO ID links to tree view) (see all 28 ): About this table
About GeneDecksing
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Drugs & Compoundsfor ALDOB gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section About GeneDecksing Browse Tocris compounds for ALDOB 6 HMDB Compounds for ALDOB About this table 3 DrugBank Compounds for ALDOB About this table 10/14 Novoseek chemical compound relationships for ALDOB gene (see all 14 ) About this table
Compound
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
fructose 1-phosphate
93.1
7
2371280 (1), 2211642 (1), 1928090 (1), 7832803 (1) (see all 7 )
fructose-1,6-bisphosphate
85.2
6
2211642 (1), 7832803 (1), 11257525 (1), 1631039 (1) (see all 5 )
fructose
84.8
48
10970798 (2), 12417303 (2), 1856829 (2), 1772121 (2) (see all 36 )
phosphoenolpyruvate
58.5
5
8838317 (1), 15311963 (1), 19660180 (1), 7565696 (1)
mannitol
33.2
1
2207353 (1)
alpha-ketoglutarate
25.9
2
10944108 (1), 10967120 (1)
glyceraldehyde 3-phosphate
17.4
1
16097891 (1)
sucrose
6.13
2
2207353 (1), 7816629 (1)
atp
3.5
1
16097891 (1)
glucose
1.23
4
2341157 (1), 10944108 (1), 10967120 (1)
ALDOB
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Transcriptsfor ALDOB gene (Secondary structures according to
fRNAdb ,Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for ALDOB gene: NM_000035.3 Unigene Cluster for ALDOB:
Aldolase B, fructose-bisphosphate Hs.530274 [show with all ESTs ] Unigene Representative Sequence: AK128504 3 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000374855 (uc004bbk.2 ) ENST00000374853 ENST00000468981 Clone OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 3 )human mouse rat OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: ALDOB (NM_000035 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ALDOB Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat ALDOB
Additional cDNA sequence: AK026411.1 AK128504.1 AK290795.1 BC005314.1 BC029399.1 X00270.1 X01098.1 X02747.1
19 DOTS entries : DT.85101542 DT.92024710
DT.91778960 DT.100828753 DT.75154237 DT.91778889 DT.100029196 DT.100828761 DT.100828759 DT.404038 DT.95175038 DT.91778917 DT.95175048 DT.100828751 DT.95175043 DT.121150360 DT.95175040 DT.95175041 DT.40133653 24/295 AceView cDNA sequences (see all 295 ):
CB163695 H51654 CR613920 BX406719 CA866780 AI580305 CA866511 CB163242 CR606411 AI061606 H72200 BM352265 T40057 BX464276 CR617866 AA377092 AA029579 BX448550 CR604271 AL532528 AV657366 CR605801 AA377181 H51076 GeneLoc Exon Structure
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Expression for ALDOB gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section ALDOB expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: --
About this image ALDOB expression in embryonic tissues and stem cells About this table 1 LifeMap In Vivo Development Anatomical Compartment/CellTissue Category (developmental path) Liver Liver Lobule Liver Expression: Experimental details:
In-situ hybridization
See ALDOB Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for ALDOB SOURCE GeneReport for Unigene cluster: Hs.530274 SABiosciences Expression via Pathway-Focused PCR Array including ALDOB : Primer OriGene genome-wide validated SYBR primer pairs in human mouse rat Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALDOB
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Orthologsfor ALDOB gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for ALDOB gene from 8/28 species (see all 28 ) About this table
Organism
Taxonomic
Gene
Description
Human
Orthology
Details
mouse Mammalia Aldob1 5
aldolase B, fructose-bisphosphate1, 5
90.75(n) 1 95.88(a) 1
4 (26.57 cM) 5 230163 1 NM_144903.2 1 NP_659152.1 1 49535995 5
chicken Aves ALDOB1
aldolase B, fructose-bisphosphate
75.55(n) 80.77(a)
427308 NM_001007977.1 NP_001007978.1
lizard Reptilia ALDOB6
--
82(a)
1 ↔ 1
2(58782580-58792268)
zebrafish Actinopterygii aldob2
aldolase b, fructose-bisphosphate
75.82(n)
321664 AY394965.1
fruit fly Insecta Ald3
glycolysis fructose-bisphosphate aldolase
64(a)
3 97A6 --
worm Secernentea F01F1.12a3
Fructose-biphosphate aldolase
59(a)
--
thale cress eudicotyledons AT3G529306 6 see all 8 )
fructose-bisphosphate aldolase, class I(see all 8 )
57(a) 57(a) (see all 8 )
many ↔ manymany ↔ many(see all 8 )
3(19626748-19629073) 2(15296701-15298514)
rice Liliopsida AK104719.12
--
74.52(n)
AK104719.1
ENSEMBL Gene Tree for ALDOB (if available)TreeFam Gene Tree for ALDOB (if available)
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Paralogsfor ALDOB gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for ALDOB gene ALDOA 2 ALDOC 2 2 SIMAP similar genes for ALDOB using alignment to 2 protein entries: ALDOB_HUMAN (see all proteins ):ALDOC ALDOA About GeneDecksing
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Genomic Variantsfor ALDOB gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 9 pos Sequence # AA Type More # Allele Pop Total More
and Proteopedia 
for ALDOB:
Browse Tocris compounds for 
Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine 
Anatomical Compartment 
Negative
Selective marker
Curated
Microarrays