ALDOB Gene

Aliases
for ALDOB gene

Previous GC identifers: GC09M094983 GC09M095927 GC09M097641 GC09M099563 GC09M101263 GC09M103222 GC09M073782

Summaries
for ALDOB gene

Genomic Views
for ALDOB gene

RefSeq DNA sequence:

NC_000009.11  NC_018920.1  NT_008470.19  

SwitchGear Promoter luciferase reporter plasmid: ALDOB promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ALDOB

ALDOB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M104182:  view genomic region     (about GC identifiers)

Proteins
for ALDOB gene

3 PDB 3D structures from and Proteopedia for ALDOB:

1QO5 (3D)        1XDL (3D)        1XDM (3D)    

Explore the universe of human proteins at neXtProt for ALDOB: NX_P05062

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: ALDOB OriGene Protein Over-expression Lysate: ALDOB OriGene Custom Protein Services for ALDOB
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	Novus Biologicals ALDOB Proteins Novus Biologicals ALDOB Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for ALDOB
	Uscn Proteins for ALDOB

Gene Ontology (GO): 5/11 cellular component terms (GO ID links to tree view) (see all 11):    About this table

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	OriGene Antibodies (see all 6): ALDOB OriGene Custom Antibody Services for ALDOB
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	Abcam antibodies for ALDOB
	Uscn Antibodies for ALDOB
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	GenScript Custom Assay Services for ALDOB
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	Uscn ELISAs and CLIAs for ALDOB

Protein Domains /
Families
for ALDOB gene

ProtoNet protein and cluster: P05062

Function
for ALDOB gene

miRNA Products:		OriGene 3'-UTR Clone: ALDOB Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ALDOB
		5 QIAGEN miScript miRNA Assays for microRNAs that regulate ALDOB:
		hsa-miR-29a* hsa-miR-2278 hsa-miR-32* hsa-miR-1301 hsa-miR-551b*
		SwitchGear 3'UTR luciferase reporter plasmid: ALDOB 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ALDOB (see all 7) OriGene shRNA RFP: ALDOB OriGene siRNA: ALDOB
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ALDOB

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for ALDOB

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ALDOB (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ALDOB OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: ALDOB (NM_000035)
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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALDOB

Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

Pathways & Interactions
for ALDOB gene

	Super-pathway	contained gene-specific pathways
1	Glycolysis and gluconeogenesis (short map)	Glycolysis and gluconeogenesis (short map) 1.00 Glycolysis and Gluconeogenesis 0.60 Glycolysis and gluconeogenesis (short map) 0.97 Glycolysis / Gluconeogenesis 0.41
2	Glucose metabolism	Glucose metabolism 1.00 Glycolysis 0.44 Gluconeogenesis 0.50
3	Fructose catabolism	Fructose catabolism 1.00 sucrose degradation V (mammalian) 0.33 Polyol pathway 0.50
4	Metabolism	Metabolism 1.00 Metabolic pathways 0.38
5	gluconeogenesis I	gluconeogenesis I 1.00 glycolysis I 0.58

1 EMD Millipore Pathway for ALDOB

Glycolysis and gluconeogenesis (short map)

1 GeneGo (Thomson Reuters) Pathway for ALDOB

Glycolysis and gluconeogenesis (short map)

5/6 BioSystems Pathways for ALDOB

	Polyol pathway
	sucrose degradation V (mammalian)
	Glycolysis and Gluconeogenesis
	FOXA2 and FOXA3 transcription factor networks
	glycolysis I

5/6        Reactome Pathways for ALDOB

	Gluconeogenesis
	Metabolism of carbohydrates
	Metabolism
	Glucose metabolism
	Fructose catabolism

4         Kegg Pathways  (Kegg details for ALDOB)

	Glycolysis / Gluconeogenesis
	Pentose phosphate pathway
	Fructose and mannose metabolism
	Metabolic pathways

ALDOB for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ALDOB

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/56 Interacting proteins for ALDOB (P05062^{1, 3} ENSP00000363988⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 56)

Gene Ontology (GO): 5/28 biological process terms (GO ID links to tree view) (see all 28):    About this table

Drugs & Compounds
for ALDOB gene

Transcripts
for ALDOB gene

Expression
for ALDOB gene

ALDOB expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

1 LifeMap In Vivo Development Anatomical Compartment/Cell
	Tissue Anatomical Compartment Cell			Category (developmental path)
	LiverLiver Lobule			Liver
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ALDOB Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ALDOB
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ALDOB

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALDOB

Orthologs
for ALDOB gene

Paralogs
for ALDOB gene

Paralogs for ALDOB gene

ALDOA²  ALDOC²  

2 SIMAP similar genes for ALDOB using alignment to 2 protein entries:     ALDOB_HUMAN (see all proteins):

ALDOC    ALDOA

ALDOB for paralogs           About GeneDecksing

Genomic Variants
for ALDOB gene

10/371 NCBI SNPs in ALDOB are shown (see all 371)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 9 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs1182044291,2	C	pathogenic	104967850(-)	AGTTCC/TGAGAA	2	R *	stg1		1		NA	4552
rs18005461,2	C,F,	pathogenic	104970177(-)	GGCGTG/CCTGTG	2	/P /A	mis1		4		NA EU	5879
rs769172431,2	C,F,	pathogenic	104970253(+)	TGCTGG/TCGTAG	2	D A	mis1		2		NA EU	5873
rs783409511,2	C	pathogenic	104975848(-)	GCTAAC/GTGCCA	2	N K	mis1		1		EU	1321
rs772452281,2		--	73782046(+)	TGTATA/GACTGT	1	--	ds5001		0	--	--	--	--
rs412960511,2		--	73782423(+)	TTCCTG/AACTCT	1	--	ut31		1		NA	120
rs123442771,2	C,H	--	73782497(+)	TTTTAT/GATTGT	1	--	ut31 ese3		4		NS EA	420
rs177728391,2	C,F,H,	--	73782645(+)	CTGGAC/TGTGCA	1	--	ut31 ese3		9		NA NS EA WA	790
rs123475191,2	C,H,	--	73782831(+)	ATTTAG/TATTGG	1	--	ut31		4		NS EA	420
rs412960491,2	F,	--	73782930(+)	TTTAAT/CTGAGC	1	--	ut31		2		WA NA	238

HapMap Linkage Disequilibrium report for ALDOB (104182842 - 104198105 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for ALDOB: --
Human Gene Mutation Database (HGMD): ALDOB

Locus Specific Mutation Databases (LSDB): ALDOB

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ALDOB

DNA2.0 Custom Variant and Variant Library Synthesis for ALDOB

Disorders / Diseases
for ALDOB gene

19 diseases for ALDOB

8 Novoseek disease relationships for ALDOB gene    About this table

Publications
for ALDOB gene

PubMed articles for ALDOB gene, integrated from 9 sources (see all 136) (see top 10): (articles sorted by number of sources associating them with ALDOB)

Utopia: connect your pdf to the dynamic world of online information

1. The spectrum of aldolase B (ALDOB) mutations and the prevalence of hereditary fructose intolerance in Central Europe. (PubMed id 15880727)^{1, 2, 9} Santer R.... Schneppenheim R. (2005)
2. Functional and molecular modelling studies of two hereditary fructose intolerance-causing mutations at arginine 303 in human liver aldolase. (PubMed id 10970798)^{1, 2, 9} Santamaria R.... Salvatore F. (2000)
3. Six novel alleles identified in Italian hereditary fructose intolerance patients enlarge the mutation spectrum of the aldolase B gene. (PubMed id 15532022)^{1, 2, 9} Esposito G.... Salvatore F. (2004)
4. The structure of human liver fructose-1,6-bisphosphate aldolase. (PubMed id 11679716)^{1, 2, 9} Dalby A.R.... Littlechild J.A. (2001)
5. A partially active mutant aldolase B from a patient with hereditary fructose intolerance. (PubMed id 8299883)^{1, 2, 9} Brooks C.C. and Tolan D.R. (1994)
6. A new aldolase B variant, N334K, is a common cause of hereditary fructose intolerance in Yugoslavia. (PubMed id 2336380)^{1, 2, 9} Cross N.C.P.... Cox T.M. (1990)
7. Molecular analysis of aldolase B genes in hereditary fructose intolerance. (PubMed id 1967768)^{1, 2, 9} Cross N.C.P.... Cox T.M. (1990)
8. Screening for hereditary fructose intolerance mutations by reverse dot-blot. (PubMed id 10024431)^{1, 2, 9} Lau J. and Tolan D.R. (1999)
9. Genetic variations in humans associated with differences in the course of hepatitis C. (PubMed id 15063762)^{1, 4} Saito T....Kawata S. (2004)
10. The temperature dependence of activity and structure for the most prevalent mutant aldolase B associated with hereditary fructose intolerance. (PubMed id 12464284)^{1, 4} Malay A.D....Tolan D.R. (2002)
11. Molecular analysis of the aldolase B gene in patients with hereditary fructose intolerance from Spain. (PubMed id 12205126)^{1, 2} Sanchez-Gutierrez J.C.... Feliu J.E. (2002)
12. Molecular basis of hereditary fructose intolerance: mutations and polymorphisms in the human aldolase B gene. (PubMed id 8535439)^{1, 2} Tolan D.R. (1995)
13. Diverse mutations in the aldolase B gene that underlie the prevalence of hereditary fructose intolerance. (PubMed id 7717389)^{1, 2} Ali M. and Cox T.M. (1995)
14. Identification of a novel mutation (Leu 256-->Pro) in the human aldolase B gene associated with hereditary fructose intolerance. (PubMed id 8162030)^{1, 2} Ali M.... Cox T.M. (1994)
15. Construction and expression of human aldolase A and B expression plasmids in Escherichia coli host. (PubMed id 2649152)^{1, 2} Sakakibara M.... Hori K. (1989)
16. Catalytic deficiency of human aldolase B in hereditary fructose intolerance caused by a common missense mutation. (PubMed id 3383242)^{1, 2} Cross N.C.P.... Cox T.M. (1988)
17. Human aldolase B gene: characterization of the genomic aldolase B gene and analysis of sequences required for multiple polyadenylations. (PubMed id 2830249)^{1, 2} Mukai T.... Hori K. (1987)
18. Characterization of the human aldolase B gene. (PubMed id 3016456)^{1, 2} Tolan D.R. and Penhoet E.E. (1986)
19. Human aldolase isozyme gene: the structure of multispecies aldolase B mRNAs. (PubMed id 2410860)^{1, 2} Sakakibara M.... Hori K. (1985)
20. Complete amino acid sequence for human aldolase B derived from cDNA and genomic clones. (PubMed id 6585824)^{1, 2} Rottmann W.H.... Penhoet E.E. (1984)
21. Isolation and nucleotide sequence of a full-length cDNA coding for aldolase B from human liver. (PubMed id 6548561)^{1, 2} Paolella G.... Salvatore F. (1984)
22. Nucleotide sequence of a cDNA clone for human aldolase B. (PubMed id 6689266)^{1, 2} Besmond C.... Kahn A. (1983)
23. Starvation-induced lysosomal degradation of aldolase B requires glutamine 111 in a signal sequence for chaperone-mediated transport. (PubMed id 11241348)^{1, 9} Susan P.P. and Dunn W.A. (2001)
24. Clinical and genetic analysis for a Chinese family with hereditary fructose intolerance. (PubMed id 17955389)^{1, 9} Chi Z.N....Ning G. (2007)
25. Semi-automated, reverse-hybridization detection of multiple mutations causing hereditary fructose intolerance. (PubMed id 17292585)^{1, 9} Kriegshauser G....Oberkanins C. (2007)
26. Structural and functional analysis of aldolase B mutants related to hereditary fructose intolerance. (PubMed id 12417303)^{1, 9} Esposito G....Salvatore F. (2002)
27. Transferrin hypoglycosylation in hereditary fructose intolerance: using the clues and avoiding the pitfalls. (PubMed id 17457694)^{1, 9} Adamowicz M....Pronicka E. (2007)
28. Genes encoding Pir51, Beclin 1, RbAp48 and aldolase b are up or down-regulated in human primary hepatocellular carcinoma. (PubMed id 14966907)^{1, 9} Song H....Zhao M.J. (2004)
29. Expression, purification, and characterization of natural mutants of human aldolase B. Role of quaternary structure in catalysis. (PubMed id 10625657)^{1, 9} Rellos P....Cox T.M. (2000)
30. Increased prevalence of mutant null alleles that caus e hereditary fructose intolerance in the American population. (PubMed id 20033295)^{1, 9} Coffee E.M....Tolan D.R. (2010)
31. Hereditary fructose intolerance: frequency and spectrum mutations of the aldolase B gene in a large patients cohort from France--identification of eight new mutations. (PubMed id 18541450)^{1, 9} Davit-Spraul A....Baussan C. (2008)
32. Aldolase B mutations and prevalence of hereditary fructose intolerance in a Polish population. (PubMed id 16406649)^{1, 9} Gruchota J....Pl/oski R. (2006)
33. The biochemical basis of hereditary fructose intolera nce. (PubMed id 20162364)^{1, 9} Bouteldja N. and Timson D.J. (2010)
34. Large-scale search of SNPs for type 2 DM susceptibility genes in a Japanese population. (PubMed id 12646233)^{4, 9} Daimon M....Kato T. (2003)
35. Mode of interactions of human aldolase isozymes with cytoskeletons. (PubMed id 9244396)^{1, 9} Kusakabe T....Hori K. (1997)
36. Aldolase B knockdown prevents high glucose-induced met hylglyoxal overproduction and cellular dysfunction in endothelial cells. (PubMed id 22911800)¹ Liu J....Wu L. (2012)
37. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)
38. Genome-wide association study identifies loci influenc ing concentrations of liver enzymes in plasma. (PubMed id 22001757)¹ Chambers J.C....Kooner J.S. (2011)
39. Stabilization of the predominant disease-causing aldo lase variant (A149P) with zwitterionic osmolytes. (PubMed id 21166391)¹ Stopa J.D....Tolan D.R. (2011)
40. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)¹ OlA!h J....OvA!di J. (2011)
41. Mutations in the promoter region of the aldolase B ge ne that cause hereditary fructose intolerance. (PubMed id 20882353)¹ Coffee E.M. and Tolan D.R. (2010)
42. Hereditary fructose intolerance: functional study of two novel ALDOB natural variants and characterization of a partial gene deletio n. (PubMed id 20848650)¹ Esposito G....Salvatore F. (2010)
43. Secreted protein acidic and rich in cysteine (SPARC) gene polymorphism association with hepatocellular carcinoma in Italian patients . (PubMed id 19817957)¹ Segat L....Crovella S. (2009)
44. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)¹ Barbe L....Andersson-Svahn H. (2008)
45. Five mucosal transcripts of interest in ulcerative colitis identified by quantitative real-time PCR: a prospective study. (PubMed id 18700007)¹ Eriksson A....Lange S. (2008)
46. Novel interaction partners of Bardet-Biedl syndrome proteins. (PubMed id 18000879)¹ Oeffner F....Grzeschik K.H. (2008)
47. Physical interaction between aldolase and vacuolar H+-ATPase is essential for the assembly and activity of the proton pump. (PubMed id 17576770)¹ Lu M....Gluck S.L. (2007)
48. How many drug targets are there? (PubMed id 17139284)⁷ Overington J.P....Hopkins A.L. (2006)
49. Drugs, their targets and the nature and number of dru g targets. (PubMed id 17016423)⁷ Imming P....Meyer A. (2006)
50. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)² Humphray S.J.... Dunham I. (2004)
51. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
52. Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver. (PubMed id 11752456)¹ Xu X.R.... Han Z.G. (2001)
53. Interaction between aldolase and vacuolar H+-ATPase: evidence for direct coupling of glycolysis to the ATP-hydrolyzing proton pump. (PubMed id 11399750)¹ Lu M.... Gluck S.L. (2001)
54. The Protein Data Bank. (PubMed id 10592235)⁷ Berman H.M....Bourne P.E. (2000)
55. The structural gene for aldolase B (ALDB) maps to 9q13----32. (PubMed id 3000275)¹ Henry I....Junien C. (1985)
56. Identification of conserved promoter elements for aldB and isozyme specific residues in aldolase B. (PubMed id 10327593)⁹ Berardini T.Z....Tolan D.R. (1999)
57. Aberrant expression of the glycolytic enzymes aldolase B and type II hexokinase in hepatocellular carcinoma are predictive markers for advanced stage, early recurrence and poor prognosis. (PubMed id 18357395)⁹ Peng S.Y....Hsu H.C. (2008)
58. Chromosomal and regional localization of the loci for IGKC, IGGC, ALDB, HOXB, GPT, and PRNP in the American mink (Mustela vison): comparisons with human and mouse. (PubMed id 8563168)⁹ Khlebodarova T.M....Brusgaard K. (1995)
59. Initiation zone of DNA replication at the aldolase B locus encompasses transcription promoter region. (PubMed id 7816629)⁹ Zhao Y....Tsutsumi K. (1994)
60. Human aldolase B: liver-specific properties of the is ozyme depend on type B isozyme group-specific sequences. (PubMed id 7700871)⁹ Kusakabe T....Hori K. (1994)
61. Detection of autoantibody to aldolase B in sera from patients with troglitazone-induced liver dysfunction. (PubMed id 16115720)⁹ Maniratanachote R....Yokoi T. (2005)
62. Alteration of substrate specificity by a naturally-oc curring aldolase B mutation (Ala337-->Val) in fructose intolerance. (PubMed id 10229688)⁹ Rellos P....Cox T.M. (1999)
63. [Immunoreactivities and messenger RNA expression of aldolase A and B in human hepatoma cell lines] (PubMed id 7868061)⁹ Kimura T. (1994)
64. Comparative FISH mapping on Z chromosomes of chicken and Japanese quail. (PubMed id 10640806)⁹ Suzuki T....Matsuda Y. (1999)
65. Characterization of recombinant human aldolase B and purification by metal chelate chromatography. (PubMed id 7832803)⁹ Doyle S.A. and Tolan D.R. (1995)
66. Alteration of aldolase isozymes in serum and tissues of patients with cancer and other diseases. (PubMed id 8046542)⁹ Asaka M....Alpert E. (1994)
67. Competition between transcription factors HNF1 and HNF3, and alternative cell-specific activation by DBP and C/EBP contribute to the regulation of the liver-specific aldolase B promoter. (PubMed id 8383844)⁹ Gregori C....Pichard A.L. (1993)
68. Studies on chimeric fusion proteins of human aldolase isozymes A and B. (PubMed id 1631039)⁹ Takasaki Y. and Hori K. (1992)
69. Aldolase B mutations in Italian families affected by hereditary fructose intolerance. (PubMed id 1856829)⁹ Sebastio G....Cox T.M. (1991)
70. Isolation and characterization of an aldehyde dehydrogenase encoded by the aldB gene of Escherichia coli. (PubMed id 15659684)⁹ Ho K.K. and Weiner H. (2005)
71. Functional domains involved in the interaction between Orc1 and transcriptional repressor AlF-C that bind to an origin/promoter of the rat aldolase B gene. (PubMed id 12466545)⁹ Saitoh Y....Tsutsumi K. (2002)
72. PCR primers for an aldolase-B intron in acanthopterygian fishes. (PubMed id 11722793)⁹ Quattro J.M....Oswald K.J. (2001)
73. Cloning and characterization of a full-length cDNA co ding for ovine aldolase B from fetal mesonephros. (PubMed id 8086469)⁹ Gianquinto L....Cotinot C. (1994)
74. Aldolase B and fructose intolerance. (PubMed id 8299892)⁹ Cox T.M. (1994)
75. An immunochemical and immunohistochemical study of aldolase isozymes in renal cell carcinoma. (PubMed id 1856954)⁹ Zhu Y.Y....Kato K. (1991)
76. Case report: heterogeneity of aldolase B in hereditary fructose intolerance. (PubMed id 1772121)⁹ Kaiser U.B. and Hegele R.A. (1991)
77. Structural studies on aldolase isozymes through protein engineering. (PubMed id 2203067)⁹ Takasaki Y....Hori K. (1990)
78. Adult hereditary fructose intolerance. (PubMed id 19452588)⁹ Yasawy M.I....Schwend M. (2009)
79. Sequential hepatogenic transdifferentiation of adipos e tissue-derived stem cells: relevance of different extracellular signaling mol ecules, transcription factors involved, and expression of new key marker genes. (PubMed id 19660180)⁹ Bonora-Centelles A....GA^mez-LechA^n M.J. (2009)
80. Characterization of mammalian sedoheptulokinase and mechanism of formation of erythritol in sedoheptulokinase deficiency. (PubMed id 18775706)⁹ Kardon T....Schaftingen E.V. (2008)
81. Aldolase B mutations in Turkish families from central Anatolia. (PubMed id 17375533)⁹ Karabulut H.G....BAPkesoy I. (2006)
82. Proteomic profiling of proteins decreased in hepatocellular carcinoma from patients infected with hepatitis C virus. (PubMed id 15221772)⁹ Yokoyama Y....Okita K. (2004)
83. Underexpression of mRNA in human hepatocellular carcinoma focusing on eight loci. (PubMed id 12143053)⁹ Kinoshita M. and Miyata M. (2002)
84. Hereditary fructose intolerance. (PubMed id 9610797)⁹ Ali M....Cox T.M. (1998)
85. Neonatal screening for hereditary fructose intoleranc e: frequency of the most common mutant aldolase B allele (A149P) in the British population. (PubMed id 8933337)⁹ James C.L....Cox T.M. (1996)
86. A newly identified aldolase B splicing mutation (G--& gt;C, 5' intron 5) in hereditary fructose intolerance from New Zealand. (PubMed id 8829634)⁹ Ali M....Cox T.M. (1996)
87. Metabolic operons in Lactococci. (PubMed id 8586214)⁹ Renault P....Ehrlich S.D. (1995)
88. Cloning and characterisation of a fish aldolase B gen e. (PubMed id 7632737)⁹ Llewellyn L....Power D.M. (1995)
89. Null alleles of the aldolase B gene in patients with hereditary fructose intolerance. (PubMed id 8071980)⁹ Ali M....Cox T.M. (1994)
90. Assignment of 12 loci to rat chromosome 5: evidence that this chromosome is homologous to mouse chromosome 4 and to human chromosomes 9 and 1 (1p arm). (PubMed id 2341157)⁹ Szpirer C....Levan G. (1990)
91. Hereditary fructose intolerance. (PubMed id 2207353)⁹ Cox T.M. (1990)
92. Hereditary fructose intolerance caused by a nonsense mutation of the aldolase B gene. (PubMed id 2203259)⁹ Kajihara S....Hori K. (1990)
93. Serum aldolase isozyme levels in patients with cerebrovascular diseases. (PubMed id 2240017)⁹ Asaka M....Alpert E. (1990)
94. HNF4alpha and HNF1alpha dysfunction as a molecular rational for cyclosporine induced posttransplantation diabetes mellitus. (PubMed id 19252740)⁹ Borlak J. and Niehof M. (2009)
95. Long-term functional stability of human HepaRG hepatocytes and use for chronic toxicity and genotoxicity studies. (PubMed id 18347083)⁹ Josse R....Guillouzo A. (2008)
96. Different genotypes in a large Italian family with re current hereditary fructose intolerance. (PubMed id 18188031)⁹ Caciotti A....Morrone A. (2008)
97. Real-time PCR quantification analysis of five mucosal transcripts in patients with Crohn's disease. (PubMed id 18334872)⁹ Eriksson A....Lange S. (2008)
98. Thermodynamic analysis shows conformational coupling and dynamics confer substrate specificity in fructose-1,6-bisphosphate aldolase . (PubMed id 17935305)⁹ Pezza J.A....Tolan D.R. (2007)
99. The human hepatoma HepaRG cells: a highly differentiated model for studies of liver metabolism and toxicity of xenobiotics. (PubMed id 17241619)⁹ Guillouzo A....Guguen-Guillouzo C. (2007)
100. [Screening proteins in hepatocytes interacting with the middle surface protein of hepatitis B virus using the yeast-two hybrid technique] (PubMed id 17362635)⁹ Li Z.Q....Cheng J. (2007)
101. Structure of the thermolabile mutant aldolase B, A149 P: molecular basis of hereditary fructose intolerance. (PubMed id 15733923)⁹ Malay A.D....Tolan D.R. (2005)
102. Current progress in proteomic study of hepatitis C virus-related human hepatocellular carcinoma. (PubMed id 16097891)⁹ Kuramitsu Y. and Nakamura K. (2005)
103. Structure of human brain fructose 1,6-(bis)phosphate aldolase: linking isozyme structure with function. (PubMed id 15537755)⁹ Arakaki T.L.... Allen K.N. (2004)
104. Development of rainbow trout hepatoma cell lines: effect of pro-IGF-I Ea4-peptide on morphological changes and anchorage-independent growth. (PubMed id 15311963)⁹ Chen M.J....Chen T.T. (2004)
105. Spatial clustering of isozyme-specific residues reveals unlikely determinants of isozyme specificity in fructose-1,6-bisphosphate aldolase. (PubMed id 12611890)⁹ Pezza J.A....Tolan D.R. (2003)
106. Differential gene expression in rats following subacu te exposure to the anticonvulsant sodium valproate. (PubMed id 12387752)⁹ Plant N....Lord P. (2002)
107. Simple method for detection of mutations causing hereditary fructose intolerance. (PubMed id 12638940)⁹ Kullberg-Lindh C....Lindh M. (2002)
108. Structural and immunological similarities between high molecular weight zinc ion-dependent p-nitrophenylphosphatase and fructose-1,6-bisphosphate aldolase from bovine liver. (PubMed id 11257525)⁹ Pellegrini M....Panara F. (2001)
109. Hepatocyte nuclear factor-4alpha involved in type 1 maturity-onset diabetes of the young is a novel target of AMP-activated protein kinase. (PubMed id 11423471)⁹ Leclerc I....Viollet B. (2001)
110. Hereditary fructose intolerance presenting as Reye's-like syndrome: report of one case. (PubMed id 11021009)⁹ Yang T.Y....Chang M.H. (2000)
111. Molecular targets of a human HNF1 alpha mutation responsible for pancreatic beta-cell dysfunction. (PubMed id 10944108)⁹ Wang H....Wollheim C.B. (2000)
112. Hepatocyte nuclear factor 4alpha regulates the expression of pancreatic beta -cell genes implicated in glucose metabolism and nutrient-induced insulin secretion. (PubMed id 10967120)⁹ Wang H....Wollheim C.B. (2000)
113. Muscle aldolase decreases muscle FBPase sensitivity toward AMP inhibition. (PubMed id 10964712)⁹ Rakus D. and Dzugaj A. (2000)
114. Molecular cloning and characterization of a translational inhibitory protein that binds to coding sequences of human acid beta-glucosidase and other mRNAs. (PubMed id 10607473)⁹ Xu Y.-H. and Grabowski G.A. (1999)
115. [Hereditary fructose intolerance] (PubMed id 10192989)⁹ Lopes A.I....Leite M. (1998)
116. Characterization of the aldolase B intronic enhancer. (PubMed id 9737987)⁹ Gregori C....Pichard A.L. (1998)
117. Role of isozyme group-specific sequence 4 in the isoz yme-specific properties of human aldolase C. (PubMed id 9854814)⁹ Kusakabe T....Hori K. (1998)
118. Genetic variability in white leghorns revealed by chicken liver expressed sequence tags. (PubMed id 9469763)⁹ Li S....Kuhnlein U. (1998)
119. Extinction of albumin gene expression in a panel of human chromosome 2 microcell hybrids. (PubMed id 8838317)⁹ Cerosaletti K.M. and Fournier R.E. (1996)
120. Overproduction of a truncated hepatocyte nuclear factor 3 protein inhibits expression of liver-specific genes in hepatoma cells. (PubMed id 7565696)⁹ Vallet V....Kahn A. (1995)
121. Genetic analysis of a transcriptional activation pathway by using hepatoma cell variants. (PubMed id 7935424)⁹ Bulla G.A. and Fournier R.E. (1994)
122. Human aldolase C: characterization of the recombinant enzyme expressed in Escherichia coli. (PubMed id 7982900)⁹ Kusakabe T....Hori K. (1994)
123. [Congenital fructose intolerance. New molecular aspec ts] (PubMed id 7809888)⁹ Larsen K....Ogreid D. (1994)
124. Inborn errors of fructose metabolism. (PubMed id 8213611)⁹ Hommes F.A. (1993)
125. Linkage mapping of the Aldo-2, Pax-5, Ambp, and D4h9S3E loci on mouse chromosome 4 in the region of homology with human chromosome 9. (PubMed id 7508415)⁹ Pilz A....Abbott C. (1993)
126. Association of the widespread A149P hereditary fructose intolerance mutation with newly identified sequence polymorphisms in the aldolase B gene. (PubMed id 8096362)⁹ Brooks C.C. and Tolan D.R. (1993)
127. DNA diagnosis of fatal fructose intolerance from arch ival tissue. (PubMed id 8438046)⁹ Ali M....Cox T.M. (1993)
128. Differential usage of the carboxyl-terminal region among aldolase isozymes. (PubMed id 8496148)⁹ Berthiaume L....Sygusch J. (1993)
129. Immunochemical and immunohistochemical studies on three aldolase isozymes in human lung cancer. (PubMed id 2004336)⁹ Ojika T....Kato K. (1991)
130. Identification of a splice-site mutation in the aldolase B gene from an individual with hereditary fructose intolerance. (PubMed id 1928090)⁹ Brooks C.C....Tolan D.R. (1991)
131. Expression of aldolase C isozyme in renal cell carcin oma. (PubMed id 2183586)⁹ Takashi M....Kato K. (1990)
132. Partial aldolase B gene deletions in hereditary fruct ose intolerance. (PubMed id 2349937)⁹ Cross N.C. and Cox T.M. (1990)
133. Construction and properties of active chimeric enzyme s between human aldolases A and B. Analysis of molecular regions which determin e isozyme-specific functions. (PubMed id 2211642)⁹ Kitajima Y....Hori K. (1990)

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