Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ALDOB Gene

protein-coding   GIFtS: 70
GCID: GC09M104182

Aldolase B, Fructose-Bisphosphate

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Aldolase B, Fructose-Bisphosphate1 2     ALDO22
Liver-Type Aldolase2 3     Aldolase 22
ALDB2 3     Aldolase B, Fructose-Bisphosphatase2
EC 4.1.2.133 8     Fructose-Bisphosphate Aldolase B2

External Ids:    HGNC: 4171   Entrez Gene: 2292   Ensembl: ENSG000001368727   OMIM: 6127245   UniProtKB: P050623   

Export aliases for ALDOB gene to outside databases

Previous GC identifers: GC09M094983 GC09M095927 GC09M097641 GC09M099563 GC09M101263 GC09M103222 GC09M073782


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ALDOB Gene:
Fructose-1,6-bisphosphate aldolase (EC 4.1.2.13) is a tetrameric glycolytic enzyme that catalyzes the reversible
conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Vertebrates
have 3 aldolase isozymes which are distinguished by their electrophoretic and catalytic properties. Differences
indicate that aldolases A, B, and C are distinct proteins, the products of a family of related 'housekeeping'
genes exhibiting developmentally regulated expression of the different isozymes. The developing embryo produces
aldolase A, which is produced in even greater amounts in adult muscle where it can be as much as 5% of total
cellular protein. In adult liver, kidney and intestine, aldolase A expression is repressed and aldolase B is
produced. In brain and other nervous tissue, aldolase A and C are expressed about equally. There is a high degree
of homology between aldolase A and C. Defects in ALDOB cause hereditary fructose intolerance. (provided by
RefSeq, Dec 2008)

GeneCards Summary for ALDOB Gene: 
ALDOB (aldolase B, fructose-bisphosphate) is a protein-coding gene. Diseases associated with ALDOB include eumycotic mycetoma, and mycetoma, and among its related super-pathways are Glycolysis and gluconeogenesis (short map) and Fructose catabolism. GO annotations related to this gene include ATPase binding and identical protein binding. An important paralog of this gene is ALDOA.

Gene Wiki entry for ALDOB (Aldolase B) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NT_008470.19  NC_018920.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ALDOB gene promoter:
         AML1a   STAT5A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidALDOB promoter sequence
   Search SABiosciences Chromatin IP Primers for ALDOB

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ALDOB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q21.3-q22.2   Ensembl cytogenetic band:  9q31.1   HGNC cytogenetic band: 9q21.3-q22.2

ALDOB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ALDOB gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M104182:  view genomic region     (about GC identifiers)

Start:
104,182,842 bp from pter      End:
104,198,105 bp from pter
Size:
15,264 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ALDOB_HUMAN, P05062 (See protein sequence)
Recommended Name: Fructose-bisphosphate aldolase B  
Size: 364 amino acids; 39473 Da
Subunit: Homotetramer
Miscellaneous: In vertebrates, three forms of this ubiquitous glycolytic enzyme are found, aldolase A in muscle,
aldolase B in liver and aldolase C in brain
3 PDB 3D structures from and Proteopedia for ALDOB:
1QO5 (3D)        1XDL (3D)        1XDM (3D)    
Secondary accessions: Q13741 Q13742 Q5T7D6

Explore the universe of human proteins at neXtProt for ALDOB: NX_P05062

Explore proteomics data for ALDOB at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P05062

  • 4/24 DME Specific Peptides for ALDOB (P05062) (see all 24)
     GIVVGIK  PDGDHDL  LARYASI  ATLNLNA 

    ALDOB Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ALDOB Protein Expression
    REFSEQ proteins: NP_000026.2  
    ENSEMBL proteins: 
     ENSP00000363988  
    Reactome Protein details: P05062
    Human Recombinant Protein Products for ALDOB: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for ALDOB
    OriGene Protein Over-expression Lysate for ALDOB
    OriGene MassSpec for ALDOB 
    OriGene Custom Protein Services for ALDOB
    GenScript Custom Purified and Recombinant Proteins Services for ALDOB
    Novus Biologicals ALDOB Proteins
    Novus Biologicals ALDOB Lysates
    Sino Biological Recombinant Protein for ALDOB
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for ALDOB
    Cloud-Clone Corp. Proteins for ALDOB 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005815microtubule organizing center IDA18000879
    GO:0005829cytosol TAS--
    GO:0034451centriolar satellite IDA18000879

    ALDOB for ontologies           About GeneDecksing



    ALDOB Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for ALDOB
    OriGene Custom Antibody Services for ALDOB
    GenScript Custom Superior Antibodies Services for ALDOB
    Novus Biologicals ALDOB Antibodies
    Abcam antibodies for ALDOB
    Cloud-Clone Corp. Antibodies for ALDOB 
    ThermoFisher Antibody for ALDOB
    LSBio Antibodies in human, mouse, rat for ALDOB 

    Assay Products for ALDOB: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ALDOB
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ALDOB
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ALDOB 
    Cloud-Clone Corp. CLIAs for ALDOB


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR013785 Aldolase_TIM
     IPR000741 Aldolase_I

    Graphical View of Domain Structure for InterPro Entry P05062

    ProtoNet protein and cluster: P05062

    1 Blocks protein domain: IPB000741 Fructose-bisphosphate aldolase

    UniProtKB/Swiss-Prot: ALDOB_HUMAN, P05062
    Similarity: Belongs to the class I fructose-bisphosphate aldolase family


    ALDOB for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ALDOB_HUMAN, P05062
    Catalytic activity: D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate
    Biophysicochemical properties: Kinetic parameters: KM=1.6 uM for fructose 1,6-bisphosphate; KM=2.3 mM for fructose
    1-phosphate;

         Genatlas biochemistry entry for ALDOB:
    aldolase B,fructose-bisphosphate,homotetramer,fructose metabolism,induced after feeding a carbohydrate diet,energy
    pathway,same affinity for F-1-P and F-1,6-P

         Enzyme Number (IUBMB): EC 4.1.2.131 2

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004332fructose-bisphosphate aldolase activity IDA10625657
    GO:0005515protein binding IPI18000879
    GO:0008092cytoskeletal protein binding IDA9244396
    GO:0042802identical protein binding IPI10625657
    GO:0051117ATPase binding IDA17576770
         
    ALDOB for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for ALDOB:
     Decreased G3BP1 protein expres  Decreased melanin production  Decreased viability of wild-ty 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ALDOB 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ALDOB

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ALDOB 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ALDOB 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ALDOB
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate ALDOB:
    hsa-miR-29a* hsa-miR-2278 hsa-miR-32* hsa-miR-1301 hsa-miR-551b*
    SwitchGear 3'UTR luciferase reporter plasmidALDOB 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ALDOB
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ALDOB

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ALDOB
    Sirion Biotech Customized adenovirus for overexpression of ALDOB

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for ALDOB (see all 7)
    OriGene ORF clones in mouse, rat for ALDOB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ALDOB (NM_000035)
    Sino Biological Human cDNA Clone for ALDOB
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ALDOB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALDOB
    Sirion Biotech Customized lentivirus for stable overexpression of ALDOB 
                         Customized lentivirus expression plasmids for stable overexpression of ALDOB 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ALDOB
    Search LifeMap BioReagents cell lines for ALDOB
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALDOB


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ALDOB About   (see all 9)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Glycolysis and gluconeogenesis (short map)
    Glycolysis and gluconeogenesis (short map)0.60
    Conversion of glucose to acetyl CoA and entry into the TCA cycle0.46
    Glycolysis and Gluconeogenesis0.60
    Glycolysis / Gluconeogenesis0.46
    glycolysis0.50
    gluconeogenesis0.39
    2Fructose catabolism
    Fructose catabolism0.50
    sucrose degradation V (mammalian)0.33
    Polyol pathway0.50
    3Metabolism
    Metabolism0.40
    Metabolic pathways0.40
    4Glucose metabolism
    Glucose metabolism0.50
    Glycolysis0.44
    Gluconeogenesis0.50
    5Carbon metabolism
    Carbon metabolism0.37
    Biosynthesis of amino acids0.37

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for ALDOB
        Glycolysis and gluconeogenesis (short map)


    1 GeneGo (Thomson Reuters) Pathway for ALDOB
        Glycolysis and gluconeogenesis (short map)

    5/7 BioSystems Pathways for ALDOB (see all 7)
        Polyol pathway
    Glycolysis and Gluconeogenesis
    sucrose degradation V (mammalian)
    gluconeogenesis
    glycolysis


    5/6        Reactome Pathways for ALDOB (see all 6)
        Gluconeogenesis
    Metabolism of carbohydrates
    Metabolism
    Glucose metabolism
    Fructose catabolism


    5/6         Kegg Pathways  (Kegg details for ALDOB) (see all 6):
        Glycolysis / Gluconeogenesis
    Pentose phosphate pathway
    Fructose and mannose metabolism
    Metabolic pathways
    Carbon metabolism

    UniProtKB/Swiss-Prot: ALDOB_HUMAN, P05062
    Pathway: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from
    D-glucose: step 4/4


    ALDOB for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ALDOB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/56 Interacting proteins for ALDOB (P050621, 3 ENSP000003639884) via UniProtKB, MINT, STRING, and/or I2D (see all 56)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    BBS2Q9BXC91, 3, ENSP000002451574EBI-1045507,EBI-748297 I2D: score=1 STRING: ENSP00000245157
    BBS1Q8NFJ91, 3EBI-1045507,EBI-1805484 I2D: score=1 
    BBS4Q96RK41, 3, ENSP000002680574EBI-1045507,EBI-1805814 I2D: score=1 STRING: ENSP00000268057
    BBS7Q8IWZ61, 3, ENSP000002644994EBI-1045507,EBI-1806001 I2D: score=1 STRING: ENSP00000264499
    ATP6V1E1P365433, ENSP000002534134I2D: score=2 STRING: ENSP00000253413
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS--
    GO:0006000fructose metabolic process IMP3383242
    GO:0006001fructose catabolic process TAS--
    GO:0006006glucose metabolic process TAS--
    GO:0006094gluconeogenesis TAS--

    ALDOB for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ALDOB for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ALDOB

    6 HMDB Compounds for ALDOB    About this table
    CompoundSynonyms CAS #PubMed Ids
    D-Erythrose 4-phosphateD-Erythrose 4-phosphate (see all 11)585-18-2--
    D-Glyceraldehyde 3-phosphate2-hydroxy-3-(phosphonooxy)-Propanal (see all 11)142-10-9--
    Dihydroxyacetone phosphate1,3-Dihydroxy-2-propanone phosphate (see all 17)57-04-5--
    Fructose 1,6-bisphosphateD-Fructose 1,6-biphosphate (see all 16)488-69-7--
    Fructose 1-phosphateD-fructose-1-P (see all 7)15978-08-2--
    ZincZinc (see all 2)7440-66-6--

    3 DrugBank Compounds for ALDOB    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    1,3-Dihydroxyacetonephosphate-- --target--17139284 17016423 10592235
    1,6-Fructose Diphosphate (Linear Form)-- --target--17139284 17016423 10592235
    3-Phosphoglycerol-- --target--17139284 17016423 10592235

    10/14 Novoseek inferred chemical compound relationships for ALDOB gene (see all 14)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fructose 1-phosphate 93.1 7 2371280 (1), 2211642 (1), 1928090 (1), 7832803 (1) (see all 7)
    fructose-1,6-bisphosphate 85.2 6 2211642 (1), 7832803 (1), 11257525 (1), 1631039 (1) (see all 5)
    fructose 84.8 48 10970798 (2), 12417303 (2), 1856829 (2), 1772121 (2) (see all 36)
    phosphoenolpyruvate 58.5 5 8838317 (1), 15311963 (1), 19660180 (1), 7565696 (1)
    mannitol 33.2 1 2207353 (1)
    alpha-ketoglutarate 25.9 2 10944108 (1), 10967120 (1)
    glyceraldehyde 3-phosphate 17.4 1 16097891 (1)
    sucrose 6.13 2 2207353 (1), 7816629 (1)
    atp 3.5 1 16097891 (1)
    glucose 1.23 4 2341157 (1), 10944108 (1), 10967120 (1)

    Search CenterWatch for drugs/clinical trials and news about ALDOB

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ALDOB gene: 
    NM_000035.3  

    Unigene Cluster for ALDOB:

    Aldolase B, fructose-bisphosphate
    Hs.530274  [show with all ESTs]
    Unigene Representative Sequence: AK128504
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000374855(uc004bbk.2) ENST00000468981
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ALDOB
    5 QIAGEN miScript miRNA Assays for microRNAs that regulate ALDOB:
    hsa-miR-29a* hsa-miR-2278 hsa-miR-32* hsa-miR-1301 hsa-miR-551b*
    SwitchGear 3'UTR luciferase reporter plasmidALDOB 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ALDOB
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ALDOB
    Clone
    Products:
         
    OriGene clones in human, mouse for ALDOB (see all 7)
    OriGene ORF clones in mouse, rat for ALDOB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ALDOB (NM_000035)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ALDOB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALDOB
    Sirion Biotech Customized lentivirus for stable overexpression of ALDOB 
                         Customized lentivirus expression plasmids for stable overexpression of ALDOB 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ALDOB
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ALDOB
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ALDOB
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ALDOB

    Additional mRNA sequence: 

    AK026411.1 AK128504.1 AK290795.1 BC005314.1 BC029399.1 X00270.1 X01098.1 X02747.1 

    19 DOTS entries:

    DT.85101542  DT.92024710  DT.91778960  DT.100828753  DT.75154237  DT.91778889  DT.100029196  DT.100828761 
    DT.100828759  DT.404038  DT.95175038  DT.91778917  DT.95175048  DT.100828751  DT.95175043  DT.121150360 
    DT.95175040  DT.95175041  DT.40133653 

    295 AceView cDNA sequences (see top 24):

    H51076 CA866511 CR604271 AA377092 CB163242 AI061606 AA376987 BQ632154 
    BM352644 CR606411 CR617866 H51654 AA376821 BX464276 T73823 X02747 
    T40057 AV657366 AA255463 R08533 BQ631855 CB163916 AW043587 CB163649 
    AW015248 AL531549 CB164792 H72200 AI580305 CB153405 BU952574 AA029579 
    AA377353 BX406719 CA866780 CR613920 CR601412 BX448550 AL532528 NM_000035 
    BX448128 AA377053 CB163695 BQ270953 BE644901 CR626275 AV681646 CB154326 
    R83303 AA029580 CA866835 CR605801 AA377181 CR600199 AL564594 BM352265 
    AV685610 T73275 AV645373 T62117 X01098 BQ271250 BI521297 AF075378 
    CD607216 BQ777407 AA376862 BC029399 BQ788079 AA377197 AI348101 AA377360 
    AV688490 CA943665 BX097974 AA376785 T61872 AA376816 AV691198 BM352945 
    AL531104 R91454 AL532527 AA377019 AI114805 AV695445 CA774787 AA377313 
    AV690067 T51970 BI522113 AW303319 W92313 AA376974 AA377136 AA911628 
    AV687788 CA775045 AV655872 AI339607 AA341358 AL564521 AA377204 X00270 
    AF063511 CA867937 AV691009 BQ416902 BP383009 CB161903 BX447951 AW950591 
    AI110637 BX483464 AA376880 AL563945 AK026411 BU950947 AA377000 R29638 
    T64359 BI835956 AV688462 AA343362 AA582642 AI110879 AA907468 AU076844 
    AV697031 T72393 AV698049 AI928475 BX406718 CB163201 CB154687 H59966 
    T40164 T70904 T77689 AV696767 R92499 CD607220 CD607218 AV689444 
    CD607209 AV696524 T69451 T73152 AV694493 AV683874 AA376846 BU951137 
    AA808819 T74544 H91429 AV693772 T60374 AA377116 AV685794 AI809802 
    AV655935 BU952707 N53060 CA952545 BM351952 AV692594 H72098 BP382921 
    H93945 T50700 AV684950 AA577599 BG616536 T70903 AV688959 AA345086 
    T85988 T47886 AV687824 T47716 T41046 T69150 H57318 AV683845 
    T77870 CA952768 CD607212 BE856838 AL564092 AA256861 AV684340 AA295460 
    AV692935 T68105 H60774 AV695383 AV683082 AV694484 CD607211 T87158 
    AV693015 T56276 AV686408 H93946 AI278334 AV689934 AV686582 BG402660 
    W92300 T69694 T71047 T79857 T77864 BF593054 AV693946 AV693437 
    AV689544 AV696117 AV695817 CA866569 R16103 AA937905 BQ416598 H60775 
    AI140277 AA827391 T90787 AV689109 AV684330 R16002 AI004048 T73009 
    N91723 T47717 AV682151 AA376940 AV645330 AV688486 T40981 AV696186 
    AV683119 AV683319 AI262278 AA621528 T56214 N64708 AV687646 T87393 
    AV683112 T83308 AI913705 T68555 AV682373 AV657382 AV686858 AV700309 
    AV685030 AV684436 AA377195 T64171 T74855 AV685612 T77693 AV699456 
    T62814 R83397 AU100511 CD607215 AV687311 T67887 T73136 T68406 
    T62053 T68334 AA977417 AI338854 T87241 AI094547 T73269 T73646 
    T70954 AV685693 T68630 H91325 T50855 AV688336 N73247 T70953 
    T55023 T68218 T68037 T62662 T72417 T73608 T74767 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ALDOB expression in normal human tissues (normalized intensities)      ALDOB embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ALDOB Expression
    About this image


    ALDOB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/8 selected tissues (see all 8) fully expand
     
     Intestine (Gastrointestinal Tract)    fully expand to see all 5 entries
             small intestine ; glandular cells   
             small intestine   
     
     Kidney (Urinary System)    fully expand to see all 4 entries
             Presumptive Podocytes Podocyte Layer
             Metanephros
             kidney ; cells in tubules   
             visceral organ/metanephros/calyx   
     
     Liver (Hepatobiliary System)    fully expand to see all 3 entries
             Hepatocytes Liver Lobule
             Liver Lobule
             Human Hepatocyte (HH)   
     
     Lower Urinary Tract (Urinary System)    fully expand to see all 2 entries
             visceral organ   
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Myoblasts Mandibular Arch Muscles

    See ALDOB Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ALDOB

    SOURCE GeneReport for Unigene cluster: Hs.530274
        SABiosciences Expression via Pathway-Focused PCR Array including ALDOB: 
              Glucose Metabolism in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for ALDOB
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ALDOB
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ALDOB
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ALDOB
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALDOB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ALDOB gene from 8/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Aldob1 , 5 aldolase B, fructose-bisphosphate1, 5 90.75(n)1
    95.88(a)1
      4 (26.57 cM)5
    2301631  NM_144903.21  NP_659152.11 
     495359955 
    chicken
    (Gallus gallus)
    Aves ALDOB1 aldolase B, fructose-bisphosphate 75.55(n)
    80.77(a)
      427308  NM_001007977.1  NP_001007978.1 
    lizard
    (Anolis carolinensis)
    Reptilia ALDOB6
    Fructose-bisphosphate aldolase
    82(a)
    1 ↔ 1
    2(58780455-58805593)
    zebrafish
    (Danio rerio)
    Actinopterygii aldob2 aldolase b, fructose-bisphosphate 75.82(n)   321664  AY394965.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Ald3 glycolysis fructose-bisphosphate
    aldolase
    64(a)
    (best of 2)
      3 97A6   --
    worm
    (Caenorhabditis elegans)
    Secernentea F01F1.12a3 Fructose-biphosphate aldolase 59(a)
    (best of 3)
        --
    soybean
    (Glycine max)
    eudicotyledons BM177496.12   -- 77.18(n)    BM177496.1 
    rice
    (Oryza sativa)
    Liliopsida AK104719.12   -- 74.52(n)    AK104719.1 


    ENSEMBL Gene Tree for ALDOB (if available)
    TreeFam Gene Tree for ALDOB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ALDOB gene
    ALDOA2  ALDOC2  
    2 SIMAP similar genes for ALDOB using alignment to 2 protein entries:     ALDOB_HUMAN (see all proteins):
    ALDOC    ALDOA

    ALDOB for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/464 SNPs in ALDOB are shown (see all 464)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0005564
    Hereditary fructose intolerance (HFI)4--see VAR_0005562 R W mis40--------
    VAR_0582124
    Hereditary fructose intolerance (HFI)4--see VAR_0582122 L P mis40--------
    VAR_0208224
    Hereditary fructose intolerance (HFI)4--see VAR_0208222 I T mis40--------
    VAR_0005574
    Hereditary fructose intolerance (HFI)4--see VAR_0005572 N K mis40--------
    VAR_0208244
    Hereditary fructose intolerance (HFI)4--see VAR_0208242 P R mis40--------
    VAR_0582114
    Hereditary fructose intolerance (HFI)4--see VAR_0582112 C R mis40--------
    VAR_0005514
    Hereditary fructose intolerance (HFI)4--see VAR_0005512 C R mis40--------
    VAR_0208264
    Hereditary fructose intolerance (HFI)4--see VAR_0208262 V F mis40--------
    VAR_0005554
    Hereditary fructose intolerance (HFI)4--see VAR_0005552 L P mis40--------
    VAR_0005584
    Hereditary fructose intolerance (HFI)4--see VAR_0005582 A V mis40--------

    HapMap Linkage Disequilibrium report for ALDOB (104182842 - 104198105 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ALDOB:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv523287CNV Loss19592680
    nsv893626CNV Loss21882294


    Human Gene Mutation Database (HGMD): ALDOB

    Locus Specific Mutation Databases (LSDB): ALDOB
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ALDOB
    DNA2.0 Custom Variant and Variant Library Synthesis for ALDOB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 612724   
    OMIM disorders: 229600  
    UniProtKB/Swiss-Prot: ALDOB_HUMAN, P05062
  • Hereditary fructose intolerance (HFI) [MIM:229600]: Autosomal recessive disease that results in an
    inability to metabolize fructose and related sugars. Complete exclusion of fructose results in dramatic recovery;
    however, if not treated properly, HFI subjects suffer episodes of hypoglycemia, general ill condition, and risk
    of death the remainder of life. Note=The disease is caused by mutations affecting the gene represented in this
    entry

  • 18 diseases for ALDOB:    About MalaCards
    eumycotic mycetoma    mycetoma    hereditary fructose intolerance syndrome    autosomal recessive disease
    maturity-onset diabetes of the young    metabolic acidosis    hypoglycemia    hepatocellular carcinoma
    ulcerative colitis    crohn's disease    hepatitis c    hepatitis
    renal cell carcinoma    diabetes mellitus    hepatitis b    lung cancer
    pancreatitis    endotheliitis

    1 disease from the University of Copenhagen DISEASES database for ALDOB:
    Eumycotic mycetoma

    ALDOB for disorders           About GeneDecksing

    8 Novoseek inferred disease relationships for ALDOB gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hereditary fructose intolerance 98.2 37 12417303 (2), 1856829 (2), 2349937 (1), 8438046 (1) (see all 33)
    hypoglycemia 35.1 2 2207353 (1), 12638940 (1)
    hepatocellular carcinoma 21.5 4 14966907 (2), 18357395 (1)
    genetic disorder 17.7 1 11679716 (1)
    tumor liver 14.5 1 14966907 (1)
    hepatitis 0 1 16115720 (1)
    tumors 0 3 18357395 (2), 1856954 (1)
    carcinoma renal cell 0 1 2183586 (1)

    Genatlas disease: ALDOB
    fructose intolerance,hereditary,characterized by vomiting,nausea,sweating associated with hypoglycemia and
    metabolic acidosis after exposure ef dietary fructose after weaning,leading to chronic toxicity and cirrhosis of
    liver in case of persistent intake

    Genetic Association Database (GAD): ALDOB
    Human Genome Epidemiology (HuGE) Navigator: ALDOB (4 documents)

    Export disorders for ALDOB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ALDOB gene, integrated from 9 sources (see all 140):
    (articles sorted by number of sources associating them with ALDOB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The spectrum of aldolase B (ALDOB) mutations and the prevalence of hereditary fructose intolerance in Central Europe. (PubMed id 15880727)1, 2, 9 Santer R.... Schneppenheim R. (2005)
    2. Increased prevalence of mutant null alleles that caus e hereditary fructose intolerance in the American population. (PubMed id 20033295)1, 4, 9 Coffee E.M....Tolan D.R. (2010)
    3. Functional and molecular modelling studies of two hereditary fructose intolerance-causing mutations at arginine 303 in human liver aldolase. (PubMed id 10970798)1, 2, 9 Santamaria R.... Salvatore F. (2000)
    4. Aldolase B mutations and prevalence of hereditary fructose intolerance in a Polish population. (PubMed id 16406649)1, 4, 9 Gruchota J....Pl/oski R. (2006)
    5. Six novel alleles identified in Italian hereditary fructose intolerance patients enlarge the mutation spectrum of the aldolase B gene. (PubMed id 15532022)1, 2, 9 Esposito G.... Salvatore F. (2004)
    6. The structure of human liver fructose-1,6-bisphosphate aldolase. (PubMed id 11679716)1, 2, 9 Dalby A.R.... Littlechild J.A. (2001)
    7. A partially active mutant aldolase B from a patient with hereditary fructose intolerance. (PubMed id 8299883)1, 2, 9 Brooks C.C. and Tolan D.R. (1994)
    8. A new aldolase B variant, N334K, is a common cause of hereditary fructose intolerance in Yugoslavia. (PubMed id 2336380)1, 2, 9 Cross N.C.P.... Cox T.M. (1990)
    9. Molecular analysis of aldolase B genes in hereditary fructose intolerance. (PubMed id 1967768)1, 2, 9 Cross N.C.P.... Cox T.M. (1990)
    10. Screening for hereditary fructose intolerance mutations by reverse dot-blot. (PubMed id 10024431)1, 2, 9 Lau J. and Tolan D.R. (1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 229 HGNC: 417 AceView: ALDOB Ensembl:ENSG00000136872 euGenes: HUgn229
    ECgene: ALDOB Kegg: 229 H-InvDB: ALDOB

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ALDOB Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ALDOB Genetics and Cytogenetics in Oncology and Haematology
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/ALDOB

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ALDOB gene:
    Search GeneIP for patents involving ALDOB

    Licensable Technologies for ALDOB gene:
    Weizmann Institute:Diagnosis and Treatment of Alzheimer Directed Against Aldolase
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for ALDOB   OriGene RNAi products in human, mouse, rat for ALDOB  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for ALDOB  
     OriGene MassSpec something-or-other for ALDOB   OriGene clones in human, mouse for ALDOB  
     OriGene qSTAR qPCR primer pairs in human, mouse for ALDOB   OriGene Purified Protein for ALDOB  
     OriGene ORF clones in mouse, rat for ALDOB   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ALDOB   OriGene Custom Protein Services for ALDOB  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ALDOB
     QIAGEN SeqTarget long-range PCR primers for resequencing ALDOB
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ALDOB
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ALDOB
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ALDOB
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ALDOB
     GenScript Custom Purified and Recombinant Proteins Services for ALDOB GenScript cDNA clones with any tag delivered in your preferred vector for ALDOB
     GenScript Custom Assay Services for ALDOB GenScript Custom Superior Antibodies Services for ALDOB
     GenScript Custom overexpressing Cell Line Services for ALDOB CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in ALDOB promoter
     Search Chromatin IP Primers for ALDOB
     RT2 qPCR Primer Assay in human, mouse, rat ALDOB
     Search GNC Networks for ALDOB
     SABiosciences PCR Arrays including human, mouse, rat ALDOB
     Search Tocris compounds for ALDOB
     Proteins and Antibodies for ALDOB
     Browse Sino Biological Cell Lysates
     cDNA Clones for ALDOB
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     ALDOB antibodies
     ALDOB proteins
     ALDOB lysates
     Antibodies for ALDOB
     See all of Abcam's Antibodies, Kits and Proteins for ALDOB
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for ALDOB




     Proteins for ALDOB
     Antibodies for ALDOB
     ELISAs for ALDOB
     CLIAs for ALDOB
     Search LifeMap BioReagents cell lines for ALDOB
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALDOB
     SwitchGear 3'UTR luciferase reporter plasmids for ALDOB
     SwitchGear Promoter luciferase reporter plasmids for ALDOB
     ThermoFisher Antibody for ALDOB
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALDOB
     inGenious Targeting Laboratory - Custom generated mouse model solutions for ALDOB
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ALDOB
    Customized:
     lentivirus for stable overexpression of ALDOB
     lentivirus expression plasmids for stable overexpression of ALDOB
     adenovirus for overexpression of ALDOB
     LSBio Antibodies in human, mouse, rat for ALDOB
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ALDOB gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4