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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ALDOB Gene

protein-coding GIFtS: 67
GCID: GC09M104182

aldolase B, fructose-bisphosphate

Explore 19 diseases affiliated with
ALDOB via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Aldolase B, Fructose-Bisphosphate¹ ²		ALDO2²
Liver-Type Aldolase² ³		Aldolase 2²
ALDB² ³		Aldolase B, Fructose-Bisphosphatase²
EC 4.1.2.13³ ⁸		Fructose-Bisphosphate Aldolase B²

External Ids:	HGNC: 417¹	Entrez Gene: 229²	Ensembl: ENSG00000136872⁷	OMIM: 612724⁵	UniProtKB: P05062³

Export aliases for ALDOB gene to outside databases

Previous GC identifers: GC09M094983 GC09M095927 GC09M097641 GC09M099563 GC09M101263 GC09M103222 GC09M073782

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ALDOB:

Fructose-1,6-bisphosphate aldolase (EC 4.1.2.13) is a tetrameric glycolytic enzyme that catalyzes the reversible

conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Vertebrates have

3 aldolase isozymes which are distinguished by their electrophoretic and catalytic properties. Differences indicate

that aldolases A, B, and C are distinct proteins, the products of a family of related 'housekeeping' genes exhibiting

developmentally regulated expression of the different isozymes. The developing embryo produces aldolase A, which is

produced in even greater amounts in adult muscle where it can be as much as 5% of total cellular protein. In adult

liver, kidney and intestine, aldolase A expression is repressed and aldolase B is produced. In brain and other nervous

tissue, aldolase A and C are expressed about equally. There is a high degree of homology between aldolase A and C.

Defects in ALDOB cause hereditary fructose intolerance. (provided by RefSeq, Dec 2008)

Gene Wiki entry for ALDOB (Aldolase B)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000009.11 NC_018920.1 NT_008470.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ALDOB gene promoter:
AML1a STAT5A
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ALDOB promoter sequence

Search SABiosciences Chromatin IP Primers for ALDOB

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ALDOB

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q21.3-q22.2 Ensembl cytogenetic band: 9q31.1 HGNC cytogenetic band: 9q21.3-q22.2

ALDOB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ALDOB gene location

GeneLoc information about chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09M104182: view genomic region (about GC identifiers)

Start:	104,182,842 bp from pter	End:	104,198,105 bp from pter
Size:	15,264 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ALDOB_HUMAN, P05062 (See protein sequence)

Recommended Name: Fructose-bisphosphate aldolase B

Size: 364 amino acids; 39473 Da

Subunit: Homotetramer

Miscellaneous: In vertebrates, three forms of this ubiquitous glycolytic enzyme are found, aldolase A in muscle,

aldolase B in liver and aldolase C in brain

3 PDB 3D structures from and Proteopedia for ALDOB:

1QO5 (3D)

1XDL (3D)

1XDM (3D)

Secondary accessions: Q13741 Q13742 Q5T7D6

Explore the universe of human proteins at neXtProt for ALDOB: NX_P05062

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P05062

4/24 DME Specific Peptides for ALDOB (P05062) (see all 24)

GIVVGIK

PDGDHDL

LARYASI

ATLNLNA

ALDOB Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_000026.2

ENSEMBL proteins:

ENSP00000363988 ENSP00000363986

Reactome Protein details: P05062
Human Recombinant Protein Products for ALDOB:

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	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for ALDOB
	Uscn Proteins for ALDOB

Gene Ontology (GO): 5/11 cellular component terms (GO ID links to tree view) (see all 11): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	--	--
GO:0005737	cytoplasm	--	--
GO:0005764	lysosome	--	--
GO:0005792	microsome	--	--
GO:0005815	microtubule organizing center	IDA	18000879

ALDOB for ontologies About GeneDecksing

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Assay Products for ALDOB:

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	Uscn ELISAs and CLIAs for ALDOB

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ALDOB for domains About GeneDecksing

2 InterPro domains/families:

IPR013785 Aldolase_TIM

IPR000741 Aldolase_I

Graphical View of Domain Structure for InterPro Entry P05062

ProtoNet protein and cluster: P05062

1 Blocks protein family: IPB000741 Fructose-bisphosphate aldolase

UniProtKB/Swiss-Prot: ALDOB_HUMAN, P05062

Similarity: Belongs to the class I fructose-bisphosphate aldolase family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: ALDOB_HUMAN, P05062

Catalytic activity: D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate

Biophysicochemical properties: Kinetic parameters: KM=1.6 uM for fructose 1,6-bisphosphate; KM=2.3 mM for fructose

1-phosphate;

Genatlas biochemistry entry for ALDOB:

aldolase B,fructose-bisphosphate,homotetramer,fructose metabolism,induced after feeding a carbohydrate diet,energy

pathway,same affinity for F-1-P and F-1,6-P

Enzyme Number (IUBMB): EC 4.1.2.13¹ ²

Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004332	fructose-bisphosphate aldolase activity	IDA	17576770
GO:0005515	protein binding	IPI	18000879
GO:0008092	cytoskeletal protein binding	IDA	9244396
GO:0031210	phosphatidylcholine binding	--	--
GO:0042802	identical protein binding	IPI	10625657

ALDOB for ontologies About GeneDecksing

Phenotypes:
3 GenomeRNAi human phenotypes for ALDOB:

Decreased G3BP1 protein expres

Decreased melanin production

Decreased viability of wild-ty

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ALDOB

miRNA Products:		OriGene 3'-UTR Clone: ALDOB Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ALDOB
		5 QIAGEN miScript miRNA Assays for microRNAs that regulate ALDOB:
		hsa-miR-29a* hsa-miR-2278 hsa-miR-32* hsa-miR-1301 hsa-miR-551b*
		SwitchGear 3'UTR luciferase reporter plasmid: ALDOB 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ALDOB (see all 7) OriGene shRNA RFP: ALDOB OriGene siRNA: ALDOB
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		Sirion Biotech Custom design and validation of potent shRNA sequences against ALDOB

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for ALDOB
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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ALDOB (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ALDOB OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALDOB

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Glycolysis and gluconeogenesis (short map)

	Glycolysis and gluconeogenesis (short map)	1.00			Glycolysis and Gluconeogenesis	0.60
	Glycolysis and gluconeogenesis (short map)	0.97			Glycolysis / Gluconeogenesis	0.41

Glucose metabolism

	Glucose metabolism	1.00			Glycolysis	0.44
	Gluconeogenesis	0.50

Fructose catabolism

	Fructose catabolism	1.00			sucrose degradation V (mammalian)	0.33
	Polyol pathway	0.50

Metabolism

Metabolism

1.00

Metabolic pathways

0.38

gluconeogenesis I

gluconeogenesis I

1.00

glycolysis I

0.58

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for ALDOB

Glycolysis and gluconeogenesis (short map)

1 GeneGo (Thomson Reuters) Pathway for ALDOB

Glycolysis and gluconeogenesis (short map)

5/6 BioSystems Pathways for ALDOB (see all 6)

	Polyol pathway
	sucrose degradation V (mammalian)
	Glycolysis and Gluconeogenesis
	FOXA2 and FOXA3 transcription factor networks
	glycolysis I

5/6 Reactome Pathways for ALDOB (see all 6)

	Gluconeogenesis
	Metabolism of carbohydrates
	Metabolism
	Glucose metabolism
	Fructose catabolism

4 Kegg Pathways (Kegg details for ALDOB):

	Glycolysis / Gluconeogenesis
	Pentose phosphate pathway
	Fructose and mannose metabolism
	Metabolic pathways

UniProtKB/Swiss-Prot: ALDOB_HUMAN, P05062

Pathway: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose:

step 4/4

ALDOB for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ALDOB

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/56 Interacting proteins for ALDOB (P05062^{1, 3} ENSP00000363988⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 56)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
BBS2	Q9BXC9¹^,³, ENSP00000245157⁴	EBI-1045507,EBI-748297 I2D: score=1 STRING: ENSP00000245157
BBS1	Q8NFJ9¹^,³	EBI-1045507,EBI-1805484 I2D: score=1
BBS4	Q96RK4¹^,³, ENSP00000268057⁴	EBI-1045507,EBI-1805814 I2D: score=1 STRING: ENSP00000268057
BBS7	Q8IWZ6¹^,³, ENSP00000264499⁴	EBI-1045507,EBI-1806001 I2D: score=1 STRING: ENSP00000264499
ATP6V1E1	P36543³, ENSP00000253413⁴	I2D: score=2 STRING: ENSP00000253413

About this table

Gene Ontology (GO): 5/28 biological process terms (GO ID links to tree view) (see all 28): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001889	liver development	--	--
GO:0005975	carbohydrate metabolic process	TAS	--
GO:0006000	fructose metabolic process	IMP	3383242
GO:0006001	fructose catabolic process	TAS	--
GO:0006006	glucose metabolic process	TAS	--

ALDOB for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

ALDOB for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ALDOB

6 HMDB Compounds for ALDOB About this table

Compound	Synonyms	CAS #	PubMed Ids
D-Erythrose 4-phosphate	D-Erythrose 4-phosphate (see all 11)	585-18-2	--
D-Glyceraldehyde 3-phosphate	2-hydroxy-3-(phosphonooxy)-Propanal (see all 11)	142-10-9	--
Dihydroxyacetone phosphate	1,3-Dihydroxy-2-propanone phosphate (see all 17)	57-04-5	--
Fructose 1,6-bisphosphate	D-Fructose 1,6-biphosphate (see all 16)	488-69-7	--
Fructose 1-phosphate	D-fructose-1-P (see all 7)	15978-08-2	--
Zinc	Zinc (see all 2)	7440-66-6	--

3 DrugBank Compounds for ALDOB About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
1,3-Dihydroxyacetonephosphate	--	--	target	--	17139284 17016423 10592235
1,6-Fructose Diphosphate (Linear Form)	--	--	target	--	17139284 17016423 10592235
3-Phosphoglycerol	--	--	target	--	17139284 17016423 10592235

10/14 Novoseek chemical compound relationships for ALDOB gene (see all 14) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
fructose 1-phosphate	93.1	7	2371280 (1), 2211642 (1), 1928090 (1), 7832803 (1) (see all 7)
fructose-1,6-bisphosphate	85.2	6	2211642 (1), 7832803 (1), 11257525 (1), 1631039 (1) (see all 5)
fructose	84.8	48	10970798 (2), 12417303 (2), 1856829 (2), 1772121 (2) (see all 36)
phosphoenolpyruvate	58.5	5	8838317 (1), 15311963 (1), 19660180 (1), 7565696 (1)
mannitol	33.2	1	2207353 (1)
alpha-ketoglutarate	25.9	2	10944108 (1), 10967120 (1)
glyceraldehyde 3-phosphate	17.4	1	16097891 (1)
sucrose	6.13	2	2207353 (1), 7816629 (1)
atp	3.5	1	16097891 (1)
glucose	1.23	4	2341157 (1), 10944108 (1), 10967120 (1)

Search CenterWatch for drugs/clinical trials and news about ALDOB

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ALDOB gene:

NM_000035.3

Unigene Cluster for ALDOB:

Aldolase B, fructose-bisphosphate

Hs.530274 [show with all ESTs]

Unigene Representative Sequence: AK128504

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000374855(uc004bbk.2) ENST00000374853 ENST00000468981

miRNA Products:		OriGene 3'-UTR Clone: ALDOB Browse OriGene MicroRNA Expression Plasmids
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Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ALDOB

Additional cDNA sequence:

AK026411.1 AK128504.1 AK290795.1 BC005314.1 BC029399.1 X00270.1 X01098.1 X02747.1

19 DOTS entries:

DT.85101542 DT.92024710 DT.91778960 DT.100828753 DT.75154237 DT.91778889 DT.100029196 DT.100828761

DT.100828759 DT.404038 DT.95175038 DT.91778917 DT.95175048 DT.100828751 DT.95175043 DT.121150360

DT.95175040 DT.95175041 DT.40133653

295 AceView cDNA sequences (see top 24):

CB163695 H51654 CR613920 BX406719 CA866780 AI580305 CA866511 CB163242

CR606411 AI061606 H72200 BM352265 T40057 BX464276 CR617866 AA377092

AA029579 BX448550 CR604271 AL532528 AV657366 CR605801 AA377181 H51076

NM_000035 CB153405 CB163916 BQ632154 R08533 CB154326 T73823 CB164792

AA377353 CR601412 AA376987 BQ270953 CB163649 AA376821 BQ631855 CR626275

X02747 AW043587 AA377053 BE644901 R83303 BX448128 AL531549 AA255463

CR600199 AW015248 BM352644 CA866835 AL564594 AV681646 BU952574 AA029580

AA377313 CD607216 AA376974 BI835956 BI521297 AV655872 AV691009 AV690067

AA376816 AV688490 CB161903 AA341358 AV687788 AA377000 AA377197 AA907468

AL564521 CB154687 T73275 W92313 BX406718 R29638 X01098 AI348101

BQ416902 AW303319 AL563945 BP383009 T64359 AI114805 AL531104 T62117

T51970 AI928475 CA774787 BQ271250 T72393 AI339607 BQ777407 AA582642

AA911628 R91454 AA377360 BM352945 AF075378 BU950947 AF063511 AV645373

AV688462 T61872 CA775045 AV697031 AA376862 AV691198 AW950591 AV695445

X00270 CA943665 AK026411 BQ788079 AI110879 AV698049 AV685610 BX447951

AA377019 CA867937 AA377136 AA376785 AU076844 BX097974 AL532527 AA377204

AA376880 AA343362 BI522113 BC029399 AI110637 BX483464 CB163201 H72098

T60374 AA377116 AV696524 T40164 AA808819 AV655935 AV688959 BP382921

AV687824 CD607218 AV683874 T70903 BG616536 T41046 BM351952 AI809802

T69451 T50700 T85988 H57318 AV684950 H91429 BU951137 T47716

H59966 AA376846 T77689 AV696767 T70904 T47886 AV685794 CA952545

H93945 T74544 T73152 AV692594 AA577599 CD607220 BU952707 AA345086

AV689444 N53060 CD607209 AV694493 T69150 R92499 AV693772 BQ416598

AV693437 T71047 AV693015 AV695383 H60774 CD607212 AV684340 AI278334

AA937905 AI140277 T56276 AV696117 CA866569 AA295460 H60775 H93946

T77870 T87158 BG402660 AL564092 AA827391 BE856838 CA952768 T79857

CD607211 T69694 R16103 AV686582 AA256861 AV693946 W92300 AV692935

T77864 AV689544 BF593054 AV683082 AV686408 T68105 AV689934 AV683845

AV695817 AV694484 AA621528 T68555 T90787 AV685030 T83308 T47717

T40981 AV696186 AI004048 AV683112 AV657382 AV689109 T56214 T73009

AV688486 AV682151 AA376940 AV687646 AV684330 AV645330 N91723 AI913705

AV700309 AV682373 AV686858 AI262278 N64708 AV683319 R16002 T87393

AV683119 CD607215 T64171 AV699456 AV684436 T77693 AV687311 AU100511

AV685612 T74855 T62814 T67887 AA377195 R83397 T62053 T73269

AI094547 T87241 T68630 T73646 T70954 AA977417 T68334 AI338854

T68406 AV685693 T73136 T50855 H91325 T68218 T55023 T68037

AV688336 N73247 T70953 T73608 T62662 T74767 T72417

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ALDOB expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

ALDOB expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Liver

Liver Lobule

Liver

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ALDOB Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ALDOB

SOURCE GeneReport for Unigene cluster: Hs.530274

SABiosciences Expression via Pathway-Focused PCR Array including ALDOB:

Glucose Metabolism in human mouse rat

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for ALDOB gene from 8/28 species (see all 28) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Aldob^{1 , 5}	aldolase B, fructose-bisphosphate^{1, 5}	90.75(n)¹ 95.88(a)¹		4 (26.57 cM)⁵ 230163¹ NM_144903.2¹ NP_659152.1¹ 49535995⁵
chicken (Gallus gallus)	Aves	ALDOB¹	aldolase B, fructose-bisphosphate	75.55(n) 80.77(a)		427308 NM_001007977.1 NP_001007978.1
lizard (Anolis carolinensis)	Reptilia	ALDOB⁶	--	82(a)	1 ↔ 1	2(58782580-58792268)
zebrafish (Danio rerio)	Actinopterygii	aldob²	aldolase b, fructose-bisphosphate	75.82(n)		321664 AY394965.1
fruit fly (Drosophila melanogaster)	Insecta	Ald³	glycolysis fructose-bisphosphate aldolase	64(a) (best of 2)		3 97A6 --
worm (Caenorhabditis elegans)	Secernentea	F01F1.12a³	Fructose-biphosphate aldolase	59(a) (best of 3)		--
thale cress (Arabidopsis thaliana)	eudicotyledons	AT3G52930⁶ AT2G36460⁶ (see all 8)	fructose-bisphosphate aldolase, class I (see all 8)	57(a) 57(a) (see all 8)	many ↔ many many ↔ many (see all 8)	3(19626748-19629073) 2(15296701-15298514)
rice (Oryza sativa)	Liliopsida	AK104719.1²	--	74.52(n)		AK104719.1

ENSEMBL Gene Tree for ALDOB (if available)
TreeFam Gene Tree for ALDOB (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ALDOB gene

ALDOA² ALDOC²

2 SIMAP similar genes for ALDOB using alignment to 2 protein entries: ALDOB_HUMAN (see all proteins):

ALDOC ALDOA

ALDOB for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 9 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs118204429^1,2	C	pathogenic	104967850(-)	`AGTTCC/TGAGAA`	2	R *	stg¹		1		NA	4552
rs1800546^1,2	C,F	pathogenic	104970177(-)	`GGCGTG/CCTGTG`	2	/P /A	mis¹		4		NA EU	5879
rs76917243^1,2	C,F	pathogenic	104970253(+)	`TGCTGG/TCGTAG`	2	D A	mis¹		2		NA EU	5873
rs78340951^1,2	C	pathogenic	104975848(-)	`GCTAAC/GTGCCA`	2	N K	mis¹		1		EU	1321
rs77245228^1,2		--	73782046(+)	`TGTATA/GACTGT`	1	--	ds500¹		0	--	--	--	--
rs41296051^1,2		--	73782423(+)	`TTCCTG/AACTCT`	1	--	ut3¹		1		NA	120
rs12344277^1,2	C,H	--	73782497(+)	`TTTTAT/GATTGT`	1	--	ut3¹ ese³		4		NS EA	420
rs17772839^1,2	C,F,H	--	73782645(+)	`CTGGAC/TGTGCA`	1	--	ut3¹ ese³		9		NA NS EA WA	790
rs12347519^1,2	C,H	--	73782831(+)	`ATTTAG/TATTGG`	1	--	ut3¹		4		NS EA	420
rs41296049^1,2	F	--	73782930(+)	`TTTAAT/CTGAGC`	1	--	ut3¹		2		WA NA	238

HapMap Linkage Disequilibrium report for ALDOB (104182842 - 104198105 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ALDOB: --
Human Gene Mutation Database (HGMD): ALDOB

Locus Specific Mutation Databases (LSDB): ALDOB

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ALDOB for disorders           About GeneDecksing

OMIM gene information: 612724
OMIM disorders: 229600
UniProtKB/Swiss-Prot: ALDOB_HUMAN, P05062

Defects in ALDOB are the cause of hereditary fructose intolerance (HFI) [MIM:229600]. HFI is an autosomal

recessive disease that results in an inability to metabolize fructose and related sugars. Complete exclusion of

fructose results in dramatic recovery; however, if not treated properly, HFI subjects suffer episodes of hypoglycemia,

general ill condition, and risk of death the remainder of life

19 diseases for ALDOB: About MalaCards

fructose intolerance eumycotic mycetoma aldolase a deficiency bardet-biedl syndrome

maturity-onset diabetes of the young autosomal recessive disease mycetoma ulcerative colitis

renal cell carcinoma diabetes mellitus hepatocellular carcinoma hepatitis c

crohn's disease hepatitis b hepatitis carcinoma

lung cancer pancreatitis malaria

8 Novoseek disease relationships for ALDOB gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
hereditary fructose intolerance	98.2	37	12417303 (2), 1856829 (2), 2349937 (1), 8438046 (1) (see all 33)
hypoglycemia	35.1	2	2207353 (1), 12638940 (1)
hepatocellular carcinoma	21.5	4	14966907 (2), 18357395 (1)
genetic disorder	17.7	1	11679716 (1)
tumor liver	14.5	1	14966907 (1)
hepatitis	0	1	16115720 (1)
tumors	0	3	18357395 (2), 1856954 (1)
carcinoma renal cell	0	1	2183586 (1)

Genatlas disease: ALDOB

fructose intolerance,hereditary,characterized by vomiting,nausea,sweating associated with hypoglycemia and metabolic

acidosis after exposure ef dietary fructose after weaning,leading to chronic toxicity and cirrhosis of liver in case

of persistent intake

Genetic Association Database (GAD): ALDOB
Human Genome Epidemiology (HuGE) Navigator: ALDOB (4 documents)

Export disorders for ALDOB gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ALDOB gene, integrated from 9 sources (see all 136):
(articles sorted by number of sources associating them with ALDOB)

Utopia: connect your pdf to the dynamic
world of online information

The spectrum of aldolase B (ALDOB) mutations and the prevalence of hereditary fructose intolerance in Central Europe. (PubMed id 15880727)^{1, 2, 9} Santer R.... Schneppenheim R. (2005)
Functional and molecular modelling studies of two hereditary fructose intolerance-causing mutations at arginine 303 in human liver aldolase. (PubMed id 10970798)^{1, 2, 9} Santamaria R.... Salvatore F. (2000)
Six novel alleles identified in Italian hereditary fructose intolerance patients enlarge the mutation spectrum of the aldolase B gene. (PubMed id 15532022)^{1, 2, 9} Esposito G.... Salvatore F. (2004)
The structure of human liver fructose-1,6-bisphosphate aldolase. (PubMed id 11679716)^{1, 2, 9} Dalby A.R.... Littlechild J.A. (2001)
A partially active mutant aldolase B from a patient with hereditary fructose intolerance. (PubMed id 8299883)^{1, 2, 9} Brooks C.C. and Tolan D.R. (1994)
A new aldolase B variant, N334K, is a common cause of hereditary fructose intolerance in Yugoslavia. (PubMed id 2336380)^{1, 2, 9} Cross N.C.P.... Cox T.M. (1990)
Molecular analysis of aldolase B genes in hereditary fructose intolerance. (PubMed id 1967768)^{1, 2, 9} Cross N.C.P.... Cox T.M. (1990)
Screening for hereditary fructose intolerance mutations by reverse dot-blot. (PubMed id 10024431)^{1, 2, 9} Lau J. and Tolan D.R. (1999)
Genetic variations in humans associated with differences in the course of hepatitis C. (PubMed id 15063762)^{1, 4} Saito T....Kawata S. (2004)
The temperature dependence of activity and structure for the most prevalent mutant aldolase B associated with hereditary fructose intolerance. (PubMed id 12464284)^{1, 4} Malay A.D....Tolan D.R. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 229	HGNC: 417	AceView: ALDOB	Ensembl:ENSG00000136872	euGenes: HUgn229
ECgene: ALDOB	Kegg: 229	H-InvDB: ALDOB

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ALDOB	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for ALDOB	Genetics and Cytogenetics in Oncology and Haematology
GeneReviews	http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/ALDOB

Intellectual Property for ALDOB gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for ALDOB gene:
Search GeneIP for patents involving ALDOB

Licensable Technologies for ALDOB gene:

Weizmann Institute:

Diagnosis and Treatment of Alzheimer Directed Against Aldolase

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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aldolase B, fructose-bisphosphate

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ALDOB Gene

aldolase B, fructose-bisphosphate

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