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Aliases for ALDOB Gene

Aliases for ALDOB Gene

  • Aldolase, Fructose-Bisphosphate B 2 3 5
  • Aldolase B, Fructose-Bisphosphate 2 3
  • Liver-Type Aldolase 3 4
  • EC 4 61
  • ALDB 3 4
  • Aldolase B, Fructose-Bisphosphatase 3
  • Fructose-Bisphosphate Aldolase B 3
  • Aldolase 2 3
  • ALDO2 3

External Ids for ALDOB Gene

Previous GeneCards Identifiers for ALDOB Gene

  • GC09M094983
  • GC09M095927
  • GC09M097641
  • GC09M099563
  • GC09M101263
  • GC09M103222
  • GC09M104182
  • GC09M073782

Summaries for ALDOB Gene

Entrez Gene Summary for ALDOB Gene

  • Fructose-1,6-bisphosphate aldolase (EC is a tetrameric glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Vertebrates have 3 aldolase isozymes which are distinguished by their electrophoretic and catalytic properties. Differences indicate that aldolases A, B, and C are distinct proteins, the products of a family of related 'housekeeping' genes exhibiting developmentally regulated expression of the different isozymes. The developing embryo produces aldolase A, which is produced in even greater amounts in adult muscle where it can be as much as 5% of total cellular protein. In adult liver, kidney and intestine, aldolase A expression is repressed and aldolase B is produced. In brain and other nervous tissue, aldolase A and C are expressed about equally. There is a high degree of homology between aldolase A and C. Defects in ALDOB cause hereditary fructose intolerance. [provided by RefSeq, Dec 2008]

GeneCards Summary for ALDOB Gene

ALDOB (Aldolase, Fructose-Bisphosphate B) is a Protein Coding gene. Diseases associated with ALDOB include Fructose Intolerance and Posterior Myocardial Infarction. Among its related pathways are Metabolism and Glucose metabolism. GO annotations related to this gene include identical protein binding and ATPase binding. An important paralog of this gene is ALDOC.

Gene Wiki entry for ALDOB Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ALDOB Gene

Genomics for ALDOB Gene

Regulatory Elements for ALDOB Gene

Enhancers for ALDOB Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F101430 1.2 Ensembl ENCODE 8.5 -5.6 -5566 20.9 PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 CBX5 ZNF189 RNF20 TMEM246 MRPL50 TMEM246-AS1 ALDOB BAAT LOC105376184
GH09F101452 0.2 ENCODE 8.5 -17.8 -17838 1.8 TMEM246 RNF20 ZNF189 MRPL50 ALDOB TMEM246-AS1 LOC105376184
GH09F101421 1.1 ENCODE 7.9 +14.0 13953 0.9 ELF3 ARID4B THRB ZSCAN9 RAD21 RARA SLC30A9 CREM MIXL1 THAP11 ZNF189 ALDOB GC09P101420
GH09F101427 0.6 ENCODE 0.4 +7.6 7598 1.3 CEBPA RCOR2 NBN ZBTB33 RELA ZNF189 ALDOB GC09P101420
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ALDOB on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the ALDOB gene promoter:

Genomic Location for ALDOB Gene

101,420,560 bp from pter
101,435,823 bp from pter
15,264 bases
Minus strand

Genomic View for ALDOB Gene

Genes around ALDOB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ALDOB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ALDOB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ALDOB Gene

Proteins for ALDOB Gene

  • Protein details for ALDOB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Fructose-bisphosphate aldolase B
    Protein Accession:
    Secondary Accessions:
    • Q13741
    • Q13742
    • Q5T7D6

    Protein attributes for ALDOB Gene

    364 amino acids
    Molecular mass:
    39473 Da
    Quaternary structure:
    • Homotetramer. Interacts with BBS1, BBS2, BBS4 and BBS7.
    • In vertebrates, 3 forms of this ubiquitous glycolytic enzyme are found, aldolase A in muscle, aldolase B in liver and aldolase C in brain.

    Three dimensional structures from OCA and Proteopedia for ALDOB Gene

neXtProt entry for ALDOB Gene

Selected DME Specific Peptides for ALDOB Gene


Post-translational modifications for ALDOB Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ALDOB Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for ALDOB Gene

Protein Domains for ALDOB Gene

Suggested Antigen Peptide Sequences for ALDOB Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the class I fructose-bisphosphate aldolase family.
  • Belongs to the class I fructose-bisphosphate aldolase family.
genes like me logo Genes that share domains with ALDOB: view

No data available for Gene Families for ALDOB Gene

Function for ALDOB Gene

Molecular function for ALDOB Gene

GENATLAS Biochemistry:
aldolase B,fructose-bisphosphate,homotetramer,fructose metabolism,induced after feeding a carbohydrate diet,energy pathway,same affinity for F-1-P and F-1,6-P
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=1.6 uM for fructose 1,6-bisphosphate {ECO:0000269 PubMed:10970798}; KM=2.3 mM for fructose 1-phosphate {ECO:0000269 PubMed:10970798};
UniProtKB/Swiss-Prot CatalyticActivity:
D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Enzyme Numbers (IUBMB) for ALDOB Gene

Gene Ontology (GO) - Molecular Function for ALDOB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004332 fructose-bisphosphate aldolase activity IEA,IDA 9244396
GO:0005515 protein binding IPI 18000879
GO:0008092 cytoskeletal protein binding IDA 9244396
GO:0016829 lyase activity IEA --
GO:0042802 identical protein binding IPI 10625657
genes like me logo Genes that share ontologies with ALDOB: view
genes like me logo Genes that share phenotypes with ALDOB: view

Human Phenotype Ontology for ALDOB Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for ALDOB Gene

MGI Knock Outs for ALDOB:

Animal Model Products

miRNA for ALDOB Gene

miRTarBase miRNAs that target ALDOB

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for ALDOB Gene

Localization for ALDOB Gene

Subcellular locations from UniProtKB/Swiss-Prot for ALDOB Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite.

Subcellular locations from

Jensen Localization Image for ALDOB Gene COMPARTMENTS Subcellular localization image for ALDOB gene
Compartment Confidence
cytoskeleton 5
cytosol 5
extracellular 5
nucleus 4
lysosome 3
vacuole 3
chloroplast 2
endoplasmic reticulum 2
mitochondrion 2
peroxisome 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for ALDOB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005815 microtubule organizing center IEA,IDA 18000879
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
GO:0034451 centriolar satellite IDA 18000879
genes like me logo Genes that share ontologies with ALDOB: view

Pathways & Interactions for ALDOB Gene

genes like me logo Genes that share pathways with ALDOB: view

UniProtKB/Swiss-Prot P05062-ALDOB_HUMAN

  • Pathway: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.

Gene Ontology (GO) - Biological Process for ALDOB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006000 fructose metabolic process IMP 3383242
GO:0006094 gluconeogenesis TAS --
GO:0006096 glycolytic process IEA,IDA 10625657
GO:0006116 NADH oxidation IDA 17576770
GO:0030388 fructose 1,6-bisphosphate metabolic process IDA 9244396
genes like me logo Genes that share ontologies with ALDOB: view

No data available for SIGNOR curated interactions for ALDOB Gene

Drugs & Compounds for ALDOB Gene

(14) Drugs for ALDOB Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved Pharma 2231
1,3-Dihydroxyacetonephosphate Experimental Pharma Target 0
1,6-Fructose Diphosphate (Linear Form) Experimental Pharma Target 0
3-Phosphoglycerol Experimental Pharma Target 0
Glyceraldehyde-3-Phosphate Experimental Pharma 0

(11) Additional Compounds for ALDOB Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
fructose 1-phosphate
  • D-Fructose 1-phosphate
  • D-Fructose-1-P
  • D-Fructose-1-phosphate
  • Fructose 1-phosphate
  • Fructose-1-P
beta-D-Fructose 1,6-bisphosphate
D-Erythrose 4-phosphate
  • D-Erythrose 4-phosphate
  • D-Erythrose 4-PO4
  • D-Erythrose-4-P
  • D-Erythrose-4-phosphate
  • Erythrose 4-phosphate
Dihydroxyacetone phosphate
  • 1,3-Dihydroxy-2-Propanone mono(dihydrogen phosphate)
  • 1,3-Dihydroxy-2-propanone phosphate
  • 1,3-Dihydroxyacetone 1-phosphate
  • 1-Hydroxy-3-(phosphonooxy)-2-Propanone
  • 1-Hydroxy-3-(phosphonooxy)acetone
Fructose 1,6-bisphosphate
  • D-Fructose 1,6-biphosphate
  • D-Fructose 1,6-bis(dihydrogen phosphate)
  • D-Fructose 1,6-bisphosphate
  • D-Fructose 1,6-diphosphate
  • D-Fructose-1,6-bisphosphate
genes like me logo Genes that share compounds with ALDOB: view

Transcripts for ALDOB Gene

mRNA/cDNA for ALDOB Gene

Unigene Clusters for ALDOB Gene

Aldolase B, fructose-bisphosphate:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ALDOB Gene

No ASD Table

Relevant External Links for ALDOB Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ALDOB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ALDOB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ALDOB Gene

This gene is overexpressed in Liver (x23.0), Kidney - Cortex (x20.2), and Small Intestine - Terminal Ileum (x7.4).

Protein differential expression in normal tissues from HIPED for ALDOB Gene

This gene is overexpressed in Liver, secretome (25.4), Liver (19.0), and Kidney (11.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ALDOB Gene

NURSA nuclear receptor signaling pathways regulating expression of ALDOB Gene:


SOURCE GeneReport for Unigene cluster for ALDOB Gene:

genes like me logo Genes that share expression patterns with ALDOB: view

Primer Products

No data available for Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for ALDOB Gene

Orthologs for ALDOB Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ALDOB Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ALDOB 34 35
  • 99.73 (n)
(Canis familiaris)
Mammalia ALDOB 34 35
  • 92.95 (n)
(Bos Taurus)
Mammalia ALDOB 34 35
  • 92.12 (n)
(Mus musculus)
Mammalia Aldob 34 16 35
  • 90.75 (n)
(Ornithorhynchus anatinus)
Mammalia ALDOB 35
  • 90 (a)
(Rattus norvegicus)
Mammalia Aldob 34
  • 89.84 (n)
(Monodelphis domestica)
Mammalia -- 35
  • 86 (a)
-- 35
  • 83 (a)
(Gallus gallus)
Aves ALDOB 34 35
  • 75.55 (n)
(Anolis carolinensis)
Reptilia ALDOB 35
  • 82 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia aldob 34
  • 68.32 (n)
(Danio rerio)
Actinopterygii aldob 34 35
  • 71.06 (n)
fruit fly
(Drosophila melanogaster)
Insecta Ald 36 35
  • 64 (a)
CG5432 36 35
  • 51 (a)
(Caenorhabditis elegans)
Secernentea aldo-2 35
  • 60 (a)
F01F1.12a 36
  • 59 (a)
F01F1.12b 36
  • 59 (a)
aldo-1 35
  • 59 (a)
T05D4.1 36
  • 58 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.13172 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11039 35
  • 64 (a)
Species where no ortholog for ALDOB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ALDOB Gene

Gene Tree for ALDOB (if available)
Gene Tree for ALDOB (if available)

Paralogs for ALDOB Gene

Paralogs for ALDOB Gene

(2) SIMAP similar genes for ALDOB Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ALDOB: view

Variants for ALDOB Gene

Sequence variations from dbSNP and Humsavar for ALDOB Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs145078268 Hereditary fructose intolerance (HFI) [MIM:229600] 101,424,931(+) GGGCC(C/G/T)GTCCA reference, missense
rs1800546 Pathogenic, Hereditary fructose intolerance (HFI) [MIM:229600] 101,427,574(-) GGCGT(C/G)CTGTG reference, missense
rs369586696 Hereditary fructose intolerance (HFI) [MIM:229600], Pathogenic 101,421,877(+) AACAT(A/G)CTGTC reference, missense
rs41281039 Hereditary fructose intolerance (HFI) [MIM:229600], Pathogenic 101,429,943(+) GATCC(A/T)CTGCA reference, missense
rs555935217 Hereditary fructose intolerance (HFI) [MIM:229600] 101,424,932(+) GGCCC(A/G)TCCAT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ALDOB Gene

Variant ID Type Subtype PubMed ID
esv3404834 CNV insertion 20981092
nsv523287 CNV loss 19592680

Variation tolerance for ALDOB Gene

Residual Variation Intolerance Score: 46.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.66; 45.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ALDOB Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ALDOB Gene

Disorders for ALDOB Gene

MalaCards: The human disease database

(11) MalaCards diseases for ALDOB Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
fructose intolerance
  • fructose intolerance, hereditary
posterior myocardial infarction
  • posterior myocardial infarction nos
fructose-1,6-bisphosphatase deficiency
  • fructose 1 phosphate aldolase deficiency
tropical sprue
  • sprue - tropical
lactose intolerance
  • lm - lactose malabsorption
- elite association - COSMIC cancer census association via MalaCards
Search ALDOB in MalaCards View complete list of genes associated with diseases


  • Hereditary fructose intolerance (HFI) [MIM:229600]: Autosomal recessive disease that results in an inability to metabolize fructose and related sugars. Complete exclusion of fructose results in dramatic recovery; however, if not treated properly, HFI subjects suffer episodes of hypoglycemia, general ill condition, and risk of death the remainder of life. {ECO:0000269 PubMed:10024431, ECO:0000269 PubMed:10970798, ECO:0000269 PubMed:12205126, ECO:0000269 PubMed:15532022, ECO:0000269 PubMed:15880727, ECO:0000269 PubMed:1967768, ECO:0000269 PubMed:20848650, ECO:0000269 PubMed:2336380, ECO:0000269 PubMed:3383242, ECO:0000269 PubMed:8162030, ECO:0000269 PubMed:8299883}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Genatlas disease for ALDOB Gene

fructose intolerance,hereditary,characterized by vomiting,nausea,sweating associated with hypoglycemia and metabolic acidosis after exposure ef dietary fructose after weaning,leading to chronic toxicity and cirrhosis of liver in case of persistent intake

Relevant External Links for ALDOB

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ALDOB: view

Publications for ALDOB Gene

  1. Increased prevalence of mutant null alleles that cause hereditary fructose intolerance in the American population. (PMID: 20033295) Coffee E.M. … Tolan D.R. (J. Inherit. Metab. Dis. 2010) 3 22 46 64
  2. Aldolase B mutations and prevalence of hereditary fructose intolerance in a Polish population. (PMID: 16406649) Gruchota J. … PA8oski R. (Mol. Genet. Metab. 2006) 3 22 46 64
  3. The spectrum of aldolase B (ALDOB) mutations and the prevalence of hereditary fructose intolerance in Central Europe. (PMID: 15880727) Santer R. … Schneppenheim R. (Hum. Mutat. 2005) 3 4 22 64
  4. Six novel alleles identified in Italian hereditary fructose intolerance patients enlarge the mutation spectrum of the aldolase B gene. (PMID: 15532022) Esposito G. … Salvatore F. (Hum. Mutat. 2004) 3 4 22 64
  5. The structure of human liver fructose-1,6-bisphosphate aldolase. (PMID: 11679716) Dalby A.R. … Littlechild J.A. (Acta Crystallogr. D 2001) 3 4 22 64

Products for ALDOB Gene

Sources for ALDOB Gene

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