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ALDOA Gene

protein-coding GIFtS: 71

GC16P029971

aldolase A, fructose-bisphosphate
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
ALDA ^², ³
EC 4.1.2.13 ^³
MGC10942 ^²
MGC17716 ^²
MGC17767 ^²

Descriptions
Lung cancer antigen NY-LU-1 ^³
Muscle-type aldolase ^³
aldolase A, fructose-bisphosphate ^²
fructose-1,6-bisphosphate triosephosphate-lyase ^²
fructose-bisphosphate aldolase A ^²

External Ids
HGNC: 414¹
Entrez Gene: 226²
UniProtKB: P04075³
Ensembl: ENSG00000149925⁷

Search outside databases for aliases for ALDOA gene

Previous GC identifers: GC16M029079 GC16P030386 GC16P030062 GC16P030102

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ALDOA:

This gene product, Aldolase A (fructose-bisphosphate aldolase) is a glycolytic enzyme that

catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and

dihydroxyacetone phosphate. Three aldolase isozymes (A, B, and C), encoded by three different

genes, are differentially expressed during development. Aldolase A is found in the developing

embryo and is produced in even greater amounts in adult muscle. Aldolase A expression is repressed

in adult liver, kidney and intestine and similar to aldolase C levels in brain and other nervous

tissue. Aldolase A deficiency has been associated with myopathy and hemolytic anemia. Alternative

splicing of this gene results in multiple transcript variants which encode the same protein.

[provided by RefSeq]

Gene Wiki entry for ALDOA (Aldolase_A)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ALDOA gene

Entrez Gene cytogenetic band: 16p11.2 Ensembl cytogenetic band: 16p11.2 HGNC cytogenetic band: 16p11.2

ALDOA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16P029971: (about GC identifiers)

Start:	29,971,945 bp from pter
End:	29,989,242 bp from pter
Size:	17,298 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000016.8 NT_010393.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: ALDOA_HUMAN, P04075 (See protein sequence)

Recommended Name: Fructose-bisphosphate aldolase A

Size: 364 amino acids; 39420 Da

Subunit: Homotetramer

Miscellaneous: In vertebrates, three forms of this ubiquitous glycolytic enzyme are found, aldolase

A in muscle, aldolase B in liver and aldolase C in brain

PDB structures from and Proteopedia :

1ALD (3D)

2ALD (3D)

4ALD (3D)

Secondary accessions: B4DXI7 Q6FH76 Q6FI10 Q96B15 Q9BWD9 Q9UCN2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (4 alternative transcripts):

NP_000025.1 NP_001121089.1 NP_908930.1 NP_908932.1

ENSEMBL proteins:

ENSP00000336927 ENSP00000378669 ENSP00000378661

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Aldolase)
	Human Recombinant Proteins from Abnova (ALDOA)

OriGene Purified Recombinant Human Proteins (see all 2): ALDOA

5 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	18029348
GO:0005737	cytoplasm	IDA	18029348
GO:0015629	actin cytoskeleton	IDA	9244396
GO:0031674	I band	TAS	1008835
GO:0070062	extracellular vesicular exosome	IDA	17641064

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Antibodies for ALDOA:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for ALDOA
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for ALDOA (Fructose, Aldolase)
	Antibodies from Abcam (Aldolase), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ALDOA)
	Novus Biologicals Antibodies for ALDOA

Assays for ALDOA:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P04075

ProtoNet protein and cluster: P04075

1 Blocks protein family: IPB000741 Fructose-bisphosphate aldolase

UniProtKB/Swiss-Prot: ALDOA_HUMAN, P04075

Similarity: Belongs to the class I fructose-bisphosphate aldolase family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ALDOA)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ALDOA)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_001127617

Applied Biosystems Silencer® siRNAs for ALDOA

Sigma-Aldrich siRNA and siRNA Panels for ALDOA

Sigma-Aldrich shRNA for ALDOA

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ALDOA
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_000034
Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_000034
untagged cDNA clones in CMV expression vector (see all 8): BC010568

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_184041

UniProtKB/Swiss-Prot: ALDOA_HUMAN, P04075

Catalytic activity: D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde

3-phosphate

Biophysicochemical properties: Kinetic parameters: KM=52 uM for fructose 1,6-bisphosphate (at 30

degrees Celsius); Temperature dependence: Thermal denaturation midpoint (Tm) is 54.4 degrees

Celsius;

Enzyme Number (IUBMB): EC 4.1.2.13

Genatlas biochemistry entry for ALDOA:

aldolase A,fructose-bisphosphate,expressed in muscle (M type),and in most other tissues,(N and H

types),overexpressed in most lung cancers,homotetramer,fructose metabolism,energy pathway,more

affinity for F-1-P than for F-1,6-P

5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003779	actin binding	TAS	1008835
GO:0004332	fructose-bisphosphate aldolase activity	IEA	--
GO:0015631	tubulin binding	TAS	17329259
GO:0016829	lyase activity	IEA	--
GO:0042802	identical protein binding	TAS	14766013

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

4 Sigma-Aldrich "Your Favorite Gene" Pathways for ALDOA (Your Favorite Gene powered by Ingenuity)

Fructose and Mannose Metabolism
Glycolysis/Gluconeogenesis
Inositol Metabolism
Pentose Phosphate Pathway

GeneDecks ALDOA for the pathways selected above

About GeneDecksing

UniProtKB/Swiss-Prot: ALDOA_HUMAN, P04075

Pathway: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate

from D-glucose: step 4/4

Gene Network Central^TM Interacting Genes and Proteins Network for ALDOA

5/42 Interacting proteins for ALDOA (P04075^{1, 2} ENSP00000336927³) via UniProtKB, MINT, and/or STRING (see all 42 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
XRN1	Q8IZH2¹	EBI-709613, EBI-372406
HSP90AB1	P08238²	MINT-72651
YWHAZ	P63104²	MINT-3304695
DERA	ENSP00000025429³	STRING (score=.977)
GAPDHL6	ENSP00000229239³	STRING (score=.974)

About this table

5/8 Gene Ontology (GO) biological process terms (links to tree view) (see all 8 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006096	glycolysis	IEA	--
GO:0006754	ATP biosynthetic process	IMP	14615364
GO:0006941	striated muscle contraction	IMP	14615364
GO:0007015	actin filament organization	TAS	1008835
GO:0008152	metabolic process	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ALDOA
10/13 Novoseek chemical compound relationships for ALDOA gene (see all 13 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
fructose 1-phosphate	82.08	1	9244396 (1)
glyceraldehyde	69.50	2	18855937 (1)
glyceraldehyde 3-phosphate	67.27	12	16342241 (1), 16429459 (1), 17522440 (1), 12416718 (1) (see all 10)
dhap	56.79	1	14615364 (1)
fructose	43.27	3	15554702 (1), 8213611 (1)
pyruvate	33.07	4	12923786 (1), 15199064 (1), 8089148 (1), 18097564 (1)
ethanol	25.84	8	11102439 (3), 16531087 (1), 2245474 (1), 10096079 (1) (see all 5)
glycogen	23.87	1	17614033 (1)
nadh	16.93	1	17614033 (1)
atp	0.00	2	16637010 (1), 17614033 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ALDOA)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ALDOA)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_001127617

Sigma-Aldrich siRNA and siRNA Panels for ALDOA

Sigma-Aldrich shRNA for ALDOA

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000034 NM_001127617 NM_184041 NM_184043

REFSEQ mRNAs for ALDOA gene (4 alternative transcripts):

NM_000034.2 NM_001127617.1 NM_184041.1 NM_184043.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000034 NM_001127617 NM_184041 NM_184043

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_000034
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_000034
                                 untagged cDNA clones in CMV expression vector (see all 8): BC010568

Additional cDNA sequence:

AK026577.1 AK098778.1 AK301993.1 AK308495.1 AK308748.1 BC000367.2 BC004333.1 BC010660.1

BC012880.1 BC013614.1 BC015888.2 BC016170.1 BC016800.1 BX647566.1 CR536528.1 CR541880.1

CR590144.1 CR590693.1 CR591029.1 CR591040.1 CR591114.1 CR591320.1 CR592194.1 CR592372.1

CR592901.1 CR593461.1 CR593844.1 CR595043.1 CR595415.1 CR596108.1 CR596168.1 CR597349.1

CR598401.1 CR598685.1 CR599451.1 CR600065.1 CR600430.1 CR600497.1 CR601483.1 CR601868.1

CR602606.1 CR603228.1 CR603376.1 CR603458.1 CR604016.1 CR604188.1 CR604579.1 CR604738.1

CR604987.1 CR605203.1 CR605889.1 CR606828.1 CR607636.1 CR608182.1 CR608270.1 CR609612.1

CR609790.1 CR609848.1 CR610297.1 CR610948.1 CR612423.1 CR613285.1 CR614159.1 CR614487.1

CR615267.1 CR615451.1 CR615901.1 CR616711.1 CR617387.1 CR618398.1 CR619926.1 CR620269.1

CR620329.1 CR620452.1 CR620834.1 CR620913.1 CR621054.1 CR621249.1 CR622016.1 CR622195.1

CR622303.1 CR622309.1 CR622931.1 CR623675.1 CR624362.1 CR624465.1 CR624525.1 CR625362.1

CR625748.1 D28356.1 EF036496.1 EF036497.1 M11560.1 M21190.1 X05236.1

24/175 DOTS entries (see all 175 ):

DT.91982597 DT.95190480 DT.451923 DT.100060541 DT.95342631 DT.91852443 DT.95369199 DT.120698216

DT.120697488 DT.100893618 DT.102841900 DT.100893625 DT.120695238 DT.91981958 DT.120696645 DT.95349096

DT.100893576 DT.120697916 DT.100698523 DT.91678286 DT.95130849 DT.102841954 DT.95320363 DT.120696674

24/4189 AceView cDNA sequences (see all 4189 ):

CB107574 BQ437635 BQ949569 BQ431698 CB143217 F20860 BQ002458 BM460400

BM756130 BI762682 CR620452 CA391094 BQ645150 BU172970 BU735131 BE313232

BE887534 BQ674936 BU902123 BM823430 CA418995 BQ061096 BU189088 BE397037

highest scoring ESTs for ALDOA:

X05236 AA012908 AA017259 AA019579 AA021267 AA054148 AA055263 AA063476 AA079530 AA086052

Unigene Cluster for ALDOA:

Aldolase A, fructose-bisphosphate

Hs.513490 [show with all ESTs]

Unigene Representative Sequence: AK098778

GeneLoc Exon Structure

5/24 Alternative Splicing Database (ASD) splice patterns (SP) for ALDOA (see all 24 )

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	^	2a	·	2b	^	3a	·	3b	^	4a	·	4b	^	5a	·	5b	·	5c	^	6a	·	6b	·	6c	^	7a	·	7b	·	7c	^	8a	·	8b	^	9a	·	9b	·	9c	·	9d	·
SP1:											-				-																				-						-		-		-		-		-		-
SP2:															-		-																		-						-		-		-		-		-		-
SP3:																																									-		-		-		-		-		-
SP4:																																											-		-		-		-		-
SP5:

ExUns:	9e	^	10	^	11a	·	11b	·	11c	^	12a	·	12b	·	12c	^	13	^	14a	·	14b	·	14c	^	15a	·	15b	·	15c	^	16	^	17a	·	17b	^	18a	·	18b	^	19a	·	19b
SP1:	-		-												-														-
SP2:	-		-												-														-
SP3:	-		-												-														-
SP4:	-		-												-														-
SP5:			-												-														-

About this scheme

ECgene alternative splicing isoforms for ALDOA

3 Ensembl transcripts including schematic representations:

ENST00000338110 ENST00000395248 ENST00000395240

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ALDOA expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ALDOA

¹ / ² / ³

8 probe-sets matching ALDOA gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
32336_at²^{, 3}	U95-A	3	1.00	0.90	0.98	0.94	X05236	1.00	1.00	1.00	1
86570_f_at²^{, 3}	U95-E	1	0.85	1.00	0.98	1.06	AI921586	0.80	1.00	0.91	1
200966_x_at²^{, 3}	U133-A	2	1.00	0.86	--	--	NM_000034	0.60	1.00	0.82	1
214687_x_at²^{, 3}	U133-A	3	1.00	0.76	--	--	AK026577	0.80	1.00	0.91	1
238996_x_at²^{, 3}	U133-B	1	0.82	1.00	--	--	AI921586	0.80	1.00	0.91	1
200966_x_at²	U133Plus2	2	1.00	0.86	--	--	--	--	--	--	--
214687_x_at²	U133Plus2	3	1.00	0.76	--	--	--	--	--	--	--
238996_x_at²	U133Plus2	1	0.82	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GCGACCGTCA

SOURCE GeneReport for Unigene cluster: Hs.513490
Expression variation in blood from EXPOLDB for ALDOA

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ALDOA gene from 5/16 species (see all 16 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ALDOA¹	--	aldolase A, fructose-bisphosphate	92.77(n) 98.63(a)	479787 XM_536914.2 XP_536914.2
cow (Bos taurus)	ALDOA¹	--	aldolase A, fructose-bisphosphate	92.03(n) 97.8(a)	509566 XM_868071.2 XP_873164.2
rat (Rattus norvegicus)	Aldoa¹	--	aldolase A, fructose-bisphosphate	89.19(n) 96.98(a)	24189 NM_012495.1 NP_036627.1
mouse (Mus musculus)	Aldoa^{1, 5}	7⁵	aldolase A, fructose-bisphosphate^{1, 5}	90.38(n)¹ 97.8(a)¹	11674¹ NM_007438.3¹ NP_031464.1¹ AI323970⁵ AK002561⁵ (see all 22)
zebrafish (Danio rerio)	AY394966.1²	--	--	79.58(n)	336425 AY394966.1

About this table Species with no ortholog for ALDOA

ENSEMBL Gene Tree for ALDOA

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ALDOA gene

ALDOC² ALDOB²

Pseudogenes

1 related pseudogene

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/108 NCBI SNPs in ALDOA are shown (see all 108 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 38)

AB	SNP ID	Valid	Chr 16 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs3112557^1,2	C,H	29988174(+)	`TGGGGA/CCCATG`	4	D/A	mis¹ ese³		4		EU EA WA	420
--	rs4788220^1,2	A,C	29971281(+)	`tgggaA/Ggctga`	1	--	ng5¹		0	--	--	--	--
--	rs4788219^1,2	A,C	29971147(+)	`atcacA/Gccatt`	1	--	ng5¹		0	--	--	--	--
--	rs3134626^1,2	H	29988386(+)	`CTGAAG/TCCCAA`	4	K/N	mis¹		4		EU EA WA	384
--	rs3098412^1,2	H	29986376(+)	`ACCCCT/GGCATT`	4	G/C	mis¹ ese³		4		EU EA WA	362
	rs3134622^1,2	H	29982267(+)	`GGACCC/TAGGGC`	2	--	int¹ ng5¹		4		EU EA WA	416
	rs3098416^1,2	H	29988690(+)	`AGGAGG/TCGTCC`	4	A/S	mis¹ ese³ trp³		4		EU EA WA	420
--	rs11553107^1,2	H	29986403(+)	`TCCATG/CAGACA`	4	Q/E	mis¹		4		EU EA WA	406
--	rs11553108^1,2	H	29987685(+)	`GGACGG/TAGCTG`	4	G/V	mis¹ ese³		4		EU EA WA	402
	rs3098418^1,2	H	29989204(+)	`TCCGGC/GACACT`	4	--	ut3¹ ese³		4		EU EA WA	416

About this table

HapMap Linkage Disequilibrium images for ALDOA (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 103850 disorders: 611881

UniProtKB/Swiss-Prot: ALDOA_HUMAN, P04075

Defects in ALDOA are the cause of aldolase A deficiency [MIM:611881]; also known as aldoA

deficiency or red cell aldolase deficiency. Aldolase A deficiency is an autosomal recessive

disorder associated with hereditary hemolytic anemia

10/13 Novoseek disease relationships for ALDOA gene (see all 13 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
anemia hemolytic	56.10	6	2229018 (2), 14766013 (1), 1433940 (1), 15632214 (1)
urinary tract diseases	33.10	2	1509638 (1), 8486529 (1)
rhabdomyolysis	32.20	1	15632214 (1)
myopathy	28.88	4	11797371 (1), 9847997 (1), 8999331 (1), 8598869 (1)
carcinoma renal cell	17.93	3	8486529 (2), 1509638 (1)
hemolysis	16.29	2	8999331 (1), 8598869 (1)
myeloid leukemia chronic	3.55	1	1433940 (1)
cancer	2.01	7	2366323 (2), 8046542 (1), 16313824 (1), 1316419 (1) (see all 5)
cancer lung	0.13	9	2004336 (3), 14516129 (2), 1316419 (2), 9500467 (1)
tumors	0.00	5	15041719 (1), 1509638 (1), 14516129 (1), 2366323 (1) (see all 5)

About this table

Genatlas disease: ALDOA

hemolytic anemia

Human Gene Mutation Database: ALDOA
Genetic Association Database: ALDOA
Human Genome Epidemiology Navigator: ALDOA (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/164 PubMed articles for ALDOA gene (see all 164 ):

Hemolytic anemia and severe rhabdomyolysis caused by compound heterozygous mutations of the gene for erythrocyte/muscle isozyme of aldolase, ALDOA(Arg303X/Cys338Tyr). (PubMed id 14615364)^{1, 3, 4, 6} Yao D.C....Neufeld E.J. (2004)
Human aldolase A natural mutants: relationship between flexibility of the C-terminal region and enzyme function. (PubMed id 14766013)^{1, 3, 4} Esposito G.... Salvatore F. (2004)
Human aldolase A of a hemolytic anemia patient with Asp-128-->Gly substitution: characteristics of an enzyme generated in E. coli transfected with the expression plasmid pHAAD128G. (PubMed id 2229018)^{1, 3, 4} Takasaki Y.... Hori K. (1990)
The crystal structure of human muscle aldolase at 3.0-A resolution. (PubMed id 2335208)^{1, 3, 4} Gamblin S.J....Watson H.C. (1990)
Crystal structure of human muscle aldolase complexed with fructose 1,6-bisphosphate: mechanistic implications. (PubMed id 10048322)^{1, 3, 4} Dalby A.... Littlechild J.A. (1999)
Brief report: inherited metabolic myopathy and hemolysis due to a mutation in aldolase A. (PubMed id 8598869)^{1, 3, 4} Kreuder J....Lampert F. (1996)
Identification of transglutaminase substrates in HT29 colon cancer cells: use of 5-(biotinamido)pentylamine as a transglutaminase- specific probe. (PubMed id 1353685)^{1, 3, 4} Lee K.N....Conway E. (1992)
Substrate and functional diversity of lysine acetylation revealed by a proteomics survey. (PubMed id 16916647)^{3, 4} Kim S.C.... Zhao Y. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)
Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)^{3, 4} Rush J.... Comb M.J. (2005)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 226	HGNC: 414	AceView: ALDOA	Ensembl:ENSG00000149925	euGenes: HUgn226
ECgene: ALDOA	H-InvDB: ALDOA

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
GeneReviews	http://www.genetests.org/query?gene=ALDOA

Licensable Technologies for ALDOA
(Available from WIS Yeda, Salk, Tufts)

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Licensable Technologies for ALDOA gene:

Weizmann Institute:

Diagnosis and Treatment of Alzheimer Directed Against Aldolase

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for ALDOA:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ALDOA-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ALDOA		Antibodies for ALDOA
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ALDOA		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (ALDOA)
	Antibodies (ALDOA)
	Chimera RNAi (ALDOA)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for ALDOA (Fructose, Aldolase)

	Recombinant Proteins (Aldolase)
	Antibodies (Aldolase)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for ALDOA

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for ALDOA

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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ALDOA Gene

protein-coding GIFtS: 71

Aliases &
Descriptions
for ALDOA

Summaries
for ALDOA

Genomic Location
for ALDOA

Proteins
for ALDOA

Protein Domains/
Families
for ALDOA

Gene Function
for ALDOA

Pathways & Interactions
for ALDOA

Drugs & Compounds
for ALDOA

Transcripts
for ALDOA

Expression
for ALDOA

Orthologs
for ALDOA

Paralogs
for ALDOA

SNPs/Variants
for ALDOA

Disorders & Mutations
for ALDOA

Medical News
for ALDOA

Publications
for ALDOA

Search for ALDOA

Genome Databases showing ALDOA

Other Databases showing ALDOA

Specialized Databases showing ALDOA

Licensable Technologies
for ALDOA

Services
for ALDOA

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ALDOA Gene

protein-coding GIFtS: 71

Aliases & Descriptionsfor ALDOA

Summariesfor ALDOA

Genomic Locationfor ALDOA

Proteinsfor ALDOA

Protein Domains/Familiesfor ALDOA

Gene Functionfor ALDOA

Pathways & Interactionsfor ALDOA

Drugs & Compoundsfor ALDOA

Transcriptsfor ALDOA

Expression for ALDOA

Orthologsfor ALDOA

Paralogsfor ALDOA

SNPs/Variantsfor ALDOA

Disorders & Mutationsfor ALDOA

Medical Newsfor ALDOA

Publicationsfor ALDOA

Search for ALDOA

Genome Databases showing ALDOA

Other Databases showing ALDOA

Specialized Databases showing ALDOA

Licensable Technologiesfor ALDOA

Servicesfor ALDOA

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ALDOA

Summaries
for ALDOA

Genomic Location
for ALDOA

Proteins
for ALDOA

Protein Domains/
Families
for ALDOA

Gene Function
for ALDOA

Pathways & Interactions
for ALDOA

Drugs & Compounds
for ALDOA

Transcripts
for ALDOA

Expression
for ALDOA

Orthologs
for ALDOA

Paralogs
for ALDOA

SNPs/Variants
for ALDOA

Disorders & Mutations
for ALDOA

Medical News
for ALDOA

Publications
for ALDOA

Licensable Technologies
for ALDOA

Services
for ALDOA