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Aliases for ALDH9A1 Gene

Aliases for ALDH9A1 Gene

  • Aldehyde Dehydrogenase 9 Family, Member A1 2 3
  • ALDH9 3 4 6
  • Aldehyde Dehydrogenase Family 9 Member A1 3 4
  • Gamma-Aminobutyraldehyde Dehydrogenase 3 4
  • R-Aminobutyraldehyde Dehydrogenase 3 4
  • Aldehyde Dehydrogenase E3 Isozyme 3 4
  • TMABADH 3 4
  • ALDH4 3 4
  • ALDH7 3 4
  • E3 3 6
  • 4-Trimethylaminobutyraldehyde Dehydrogenase 3
  • Aldehyde Dehydrogenase (NAD+) 3
  • EC 4
  • EC 4
  • EC 63
  • EC 4
  • EC 1.2.1 63

External Ids for ALDH9A1 Gene

Previous HGNC Symbols for ALDH9A1 Gene

  • ALDH7
  • ALDH4
  • ALDH9

Previous GeneCards Identifiers for ALDH9A1 Gene

  • GC01M163266
  • GC01M161282
  • GC01M162327
  • GC01M162818
  • GC01M162363
  • GC01M163899
  • GC01M136878

Summaries for ALDH9A1 Gene

Entrez Gene Summary for ALDH9A1 Gene

  • This protein belongs to the aldehyde dehydrogenase family of proteins. It has a high activity for oxidation of gamma-aminobutyraldehyde and other amino aldehydes. The enzyme catalyzes the dehydrogenation of gamma-aminobutyraldehyde to gamma-aminobutyric acid (GABA). This isozyme is a tetramer of identical 54-kD subunits. [provided by RefSeq, Jul 2008]

GeneCards Summary for ALDH9A1 Gene

ALDH9A1 (Aldehyde Dehydrogenase 9 Family, Member A1) is a Protein Coding gene. Diseases associated with ALDH9A1 include fetal alcohol spectrum disorder and alcohol dependence. Among its related pathways are Metabolism and Arginine and proline metabolism. GO annotations related to this gene include aldehyde dehydrogenase (NAD) activity and aminobutyraldehyde dehydrogenase activity. An important paralog of this gene is ALDH1A2.

UniProtKB/Swiss-Prot for ALDH9A1 Gene

  • Converts gamma-trimethylaminobutyraldehyde into gamma-butyrobetaine. Catalyzes the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction.

Gene Wiki entry for ALDH9A1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ALDH9A1 Gene

Genomics for ALDH9A1 Gene

Regulatory Elements for ALDH9A1 Gene

Genomic Location for ALDH9A1 Gene

165,662,212 bp from pter
165,698,863 bp from pter
36,652 bases
Minus strand

Genomic View for ALDH9A1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ALDH9A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ALDH9A1 Gene

Proteins for ALDH9A1 Gene

  • Protein details for ALDH9A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    4-trimethylaminobutyraldehyde dehydrogenase
    Protein Accession:
    Secondary Accessions:
    • B2R6X1
    • B4DXY7
    • Q5VV90
    • Q6LCL1
    • Q9NZT7

    Protein attributes for ALDH9A1 Gene

    494 amino acids
    Molecular mass:
    53802 Da
    Quaternary structure:
    • Homotetramer
    • Sequence=CAH74061.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for ALDH9A1 Gene


neXtProt entry for ALDH9A1 Gene

Proteomics data for ALDH9A1 Gene at MOPED

Selected DME Specific Peptides for ALDH9A1 Gene

Post-translational modifications for ALDH9A1 Gene

  • Ubiquitination at Lys30 and Lys68
  • Modification sites at PhosphoSitePlus

Other Protein References for ALDH9A1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

Domains for ALDH9A1 Gene

Gene Families for ALDH9A1 Gene

Protein Domains for ALDH9A1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the aldehyde dehydrogenase family.
  • Belongs to the aldehyde dehydrogenase family.
genes like me logo Genes that share domains with ALDH9A1: view

Function for ALDH9A1 Gene

Molecular function for ALDH9A1 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=11 uM for 4-aminobutyraldehyde; pH dependence: Optimum pH is about 9.4 with propionaldehyde as substrate, and 7.5 with 4-aminobutyraldehyde as substrate.;
UniProtKB/Swiss-Prot CatalyticActivity:
4-trimethylammoniobutanal + NAD(+) + H(2)O = 4-trimethylammoniobutanoate + NADH
UniProtKB/Swiss-Prot CatalyticActivity:
An aldehyde + NAD(+) + H(2)O = a carboxylate + NADH
UniProtKB/Swiss-Prot CatalyticActivity:
4-aminobutanal + NAD(+) + H(2)O = 4-aminobutanoate + NADH
UniProtKB/Swiss-Prot Function:
Converts gamma-trimethylaminobutyraldehyde into gamma-butyrobetaine. Catalyzes the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction.

Enzyme Numbers (IUBMB) for ALDH9A1 Gene

Gene Ontology (GO) - Molecular Function for ALDH9A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004028 3-chloroallyl aldehyde dehydrogenase activity TAS --
GO:0004029 aldehyde dehydrogenase (NAD) activity IDA 2925663
GO:0016491 oxidoreductase activity --
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor --
GO:0019145 aminobutyraldehyde dehydrogenase activity IDA 2925663
genes like me logo Genes that share ontologies with ALDH9A1: view

Phenotypes for ALDH9A1 Gene

GenomeRNAi human phenotypes for ALDH9A1:
genes like me logo Genes that share phenotypes with ALDH9A1: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ALDH9A1

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for ALDH9A1 Gene

Localization for ALDH9A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ALDH9A1 Gene


Subcellular locations from

Jensen Localization Image for ALDH9A1 Gene COMPARTMENTS Subcellular localization image for ALDH9A1 gene
Compartment Confidence
cytosol 4
plasma membrane 4
mitochondrion 3
peroxisome 1

Gene Ontology (GO) - Cellular Components for ALDH9A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 2925663
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with ALDH9A1: view

Pathways for ALDH9A1 Gene

genes like me logo Genes that share pathways with ALDH9A1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot P49189-AL9A1_HUMAN

  • Pathway: Amine and polyamine biosynthesis; carnitine biosynthesis

Gene Ontology (GO) - Biological Process for ALDH9A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001822 kidney development IEA --
GO:0001889 liver development IEA --
GO:0006081 cellular aldehyde metabolic process IDA 8645224
GO:0008152 metabolic process --
GO:0009437 carnitine metabolic process --
genes like me logo Genes that share ontologies with ALDH9A1: view

Drugs for ALDH9A1 Gene

(1) Drugbank Compounds for ALDH9A1 Gene

Compound Status Synonyms Cas Number PubChem ID Type Actions PubMed IDs
  • 1,4-dihydronicotinamide adenine dinucleotide
606-68-8 439153 Target nutraceutical

(40) HMDB Compounds for ALDH9A1 Gene

Compound Synonyms Cas Number PubMed IDs
(S)-Methylmalonic acid semialdehyde
  • (2S)-2-methyl-3-oxopropanoate
  • 3alpha,7alpha-dihydroxy-5beta-cholestan-27-al
  • 17,20a-Dihydroxy-4-pregnen-3-one
  • 3-Aminopropanal

(120) Novoseek inferred chemical compound relationships for ALDH9A1 Gene

Compound -log(P) Hits PubMed IDs
acetaldehyde 92.6 91
gamma-aminobutyraldehyde 87.5 14
aldophosphamide 85.9 5
3,4-dihydroxyphenylacetaldehyde 85.5 3
propionaldehyde 82.3 5
genes like me logo Genes that share compounds with ALDH9A1: view

Transcripts for ALDH9A1 Gene

Unigene Clusters for ALDH9A1 Gene

Aldehyde dehydrogenase 9 family, member A1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ALDH9A1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ALDH9A1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1: - -
SP3: -

Relevant External Links for ALDH9A1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ALDH9A1 Gene

mRNA expression in normal human tissues for ALDH9A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ALDH9A1 Gene

SOURCE GeneReport for Unigene cluster for ALDH9A1 Gene Hs.2533

mRNA Expression by UniProt/SwissProt for ALDH9A1 Gene

Tissue specificity: High expression in adult liver, skeletal muscle, and kidney. Low levels in heart, pancreas, lung and brain. Expressed in all regions of the brain. Expression levels are variable in the different brain areas, with the highest levels in the spinal cord and the lowest in the occipital pole.
genes like me logo Genes that share expressions with ALDH9A1: view

Expression partners for ALDH9A1 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein differential expression in normal tissues for ALDH9A1 Gene

Orthologs for ALDH9A1 Gene

This gene was present in the common ancestor of animals.

Orthologs for ALDH9A1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ALDH9A1 35
  • 91.36 (n)
  • 96.15 (a)
ALDH9A1 36
  • 96 (a)
(Canis familiaris)
Mammalia ALDH9A1 35
  • 87.58 (n)
  • 92.71 (a)
ALDH9A1 36
  • 93 (a)
(Mus musculus)
Mammalia Aldh9a1 35
  • 84.62 (n)
  • 88.61 (a)
Aldh9a1 16
Aldh9a1 36
  • 89 (a)
(Pan troglodytes)
Mammalia ALDH9A1 35
  • 99.61 (n)
  • 99.61 (a)
ALDH9A1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Aldh9a1 35
  • 86.03 (n)
  • 90.49 (a)
(Monodelphis domestica)
Mammalia ALDH9A1 36
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia ALDH9A1 36
  • 83 (a)
(Gallus gallus)
Aves ALDH9A1 35
  • 76.11 (n)
  • 81.84 (a)
ALDH9A1 36
  • 69 (a)
(Anolis carolinensis)
Reptilia ALDH9A1 36
  • 82 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia aldh9a1 35
  • 71.04 (n)
  • 79.8 (a)
Str.4269 35
African clawed frog
(Xenopus laevis)
Amphibia MGC52697 35
(Danio rerio)
Actinopterygii aldh9a1a.1 35
  • 70.91 (n)
  • 74.95 (a)
Dr.1904 35
aldh9a1a.1 36
  • 73 (a)
aldh9a1a.2 36
  • 71 (a)
aldh9a1b 36
  • 65 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8954 35
(Caenorhabditis elegans)
Secernentea alh-12 35
  • 56.9 (n)
  • 51.08 (a)
alh-11 36
  • 35 (a)
alh-12 36
  • 49 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13430 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10696 36
  • 51 (a)
Species with no ortholog for ALDH9A1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ALDH9A1 Gene

Gene Tree for ALDH9A1 (if available)
Gene Tree for ALDH9A1 (if available)

Paralogs for ALDH9A1 Gene

(12) SIMAP similar genes for ALDH9A1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ALDH9A1: view

Variants for ALDH9A1 Gene

Sequence variations from dbSNP and Humsavar for ALDH9A1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs9164 -- 165,662,487(-) AAGCT(A/G)TATCC utr-variant-3-prime
rs11506 -- 165,662,269(-) AATTA(C/T)TTGTA utr-variant-3-prime
rs12670 -- 165,662,433(-) GGATT(A/C)GATAA utr-variant-3-prime
rs884121 -- 165,670,941(-) tgtgc(A/G)ccacc intron-variant
rs1065756 -- 165,680,614(-) CTACA(C/G)TGAGG missense, reference

Structural Variations from Database of Genomic Variants (DGV) for ALDH9A1 Gene

Variant ID Type Subtype PubMed ID
esv33662 CNV Gain 17666407
esv33411 CNV Loss 17666407
esv33567 CNV Loss 17666407
esv2555363 CNV Insertion 19546169
esv1624307 CNV Insertion 17803354

Relevant External Links for ALDH9A1 Gene

HapMap Linkage Disequilibrium report
Locus Specific Mutation Databases (LSDB)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ALDH9A1 Gene

Disorders for ALDH9A1 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for ALDH9A1 Gene in MalaCards »

(2) Diseases for ALDH9A1 Gene

(42) Novoseek inferred disease relationships for ALDH9A1 Gene

Disease -log(P) Hits PubMed IDs
alcoholism 78.5 54
liver diseases alcoholic 54.8 1
alcohol abuse 51.3 4
pancreatitis alcoholic 41.1 1
cancer 35.9 21

Relevant External Links for ALDH9A1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with ALDH9A1: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for ALDH9A1 Gene

Publications for ALDH9A1 Gene

  1. Human gamma-aminobutyraldehyde dehydrogenase (ALDH9): cDNA sequence, genomic organization, polymorphism, chromosomal localization, and tissue expression. (PMID: 8786138) Lin S.W. … Yoshida A. (Genomics 1996) 2 3 4 23
  2. Human aldehyde dehydrogenase. cDNA cloning and primary structure of the enzyme that catalyzes dehydrogenation of 4-aminobutyraldehyde. (PMID: 8269919) Kurys G. … Pietruszko R. (Eur. J. Biochem. 1993) 3 4 23
  3. Human aldehyde dehydrogenase: chromosomal assignment of the gene for the isozyme that metabolizes gamma-aminobutyraldehyde. (PMID: 8112751) McPherson J.D. … Pietruszko R. (Hum. Genet. 1994) 2 3 23
  4. Aldehyde dehydrogenase from adult human brain that dehydrogenates gamma-aminobutyraldehyde: purification, characterization, cloning and distribution. (PMID: 8645224) Kikonyogo A. … Pietruszko R. (Biochem. J. 1996) 3 4 23
  5. Human aldehyde dehydrogenase catalytic activity and structural interactions with coenzyme analogs. (PMID: 11790142) Izaguirre G. … MacKerell A. (J. Biomol. Struct. Dyn. 2001) 3 23

Products for ALDH9A1 Gene

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