Aliases for ALDH8A1 Gene
External Ids for ALDH8A1 Gene
This protein belongs to the aldehyde dehydrogenases family of proteins. It plays a role in a pathway of 9-cis-retinoic acid biosynthesis in vivo. This enzyme converts 9-cis-retinal into the retinoid X receptor ligand 9-cis-retinoic acid, and has approximately 40-fold higher activity with 9-cis-retinal than with all-trans-retinal. Therefore, it is the first known aldehyde dehydrogenase to show a preference for 9-cis-retinal relative to all-trans-retinal. Three transcript variants encoding distinct protein isoforms have been identified for this gene. [provided by RefSeq, Jul 2010]
GeneCards Summary for ALDH8A1 Gene
ALDH8A1 (Aldehyde Dehydrogenase 8 Family, Member A1) is a Protein Coding gene. GO annotations related to this gene include retinal dehydrogenase activity. An important paralog of this gene is ALDH1A2.
UniProtKB/Swiss-Prot for ALDH8A1 Gene
Converts 9-cis-retinal to 9-cis-retinoic acid. Has lower activity towards 13-cis-retinal. Has much lower activity towards all-trans-retinal. Has highest activity with benzaldehyde and decanal (in vitro). Has a preference for NAD, but shows considerable activity with NADP (in vitro).