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ALDH8A1 Gene

protein-coding   GIFtS: 51
GCID: GC06M135238

Aldehyde Dehydrogenase 8 Family, Member A1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Aldehyde Dehydrogenase 8 Family, Member A11 2     Aldehyde Dehydrogenase Family Protein2
ALDH122 3 5     EC 1.2.1.-3
Aldehyde Dehydrogenase 122 3     EC 1.2.18
DJ352A20.22     EC 1.2.1.38
Aldehyde Dehydrogenase Family 8 Member A12     

External Ids:    HGNC: 154711   Entrez Gene: 645772   Ensembl: ENSG000001185147   OMIM: 6064675   UniProtKB: Q9H2A23   

Export aliases for ALDH8A1 gene to outside databases

Previous GC identifers: GC06M134861 GC06M135085 GC06M135219 GC06M135280 GC06M132802


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ALDH8A1 Gene:
This protein belongs to the aldehyde dehydrogenases family of proteins. It plays a role in a pathway of
9-cis-retinoic acid biosynthesis in vivo. This enzyme converts 9-cis-retinal into the retinoid X receptor ligand
9-cis-retinoic acid, and has approximately 40-fold higher activity with 9-cis-retinal than with
all-trans-retinal. Therefore, it is the first known aldehyde dehydrogenase to show a preference for 9-cis-retinal
relative to all-trans-retinal. Three transcript variants encoding distinct protein isoforms have been identified
for this gene. (provided by RefSeq, Jul 2010)

GeneCards Summary for ALDH8A1 Gene:
ALDH8A1 (aldehyde dehydrogenase 8 family, member A1) is a protein-coding gene. Diseases associated with ALDH8A1 include sjogren-larsson syndrome, and retinitis. GO annotations related to this gene include retinal dehydrogenase activity. An important paralog of this gene is ALDH1L2.

UniProtKB/Swiss-Prot: AL8A1_HUMAN, Q9H2A2
Function: Converts 9-cis-retinal to 9-cis-retinoic acid. Has lower activity towards 13-cis-retinal. Has much lower
activity towards all-trans-retinal. Has highest activity with benzaldehyde and decanal (in vitro). Has a
preference for NAD, but shows considerable activity with NADP (in vitro)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000006.12  NT_025741.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ALDH8A1 gene promoter:
         TBP   Lmo2   Tal-1beta   Evi-1   YY1   E47   POU2F1   POU2F1a   TFIID   FOXO4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidALDH8A1 promoter sequence
   Search Chromatin IP Primers for ALDH8A1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ALDH8A1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q23.2   Ensembl cytogenetic band:  6q23.3   HGNC cytogenetic band: 6q24.1-q25.1

ALDH8A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ALDH8A1 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M135238:  view genomic region     (about GC identifiers)

Start:
135,238,528 bp from pter      End:
135,271,260 bp from pter
Size:
32,733 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: AL8A1_HUMAN, Q9H2A2 (See protein sequence)
Recommended Name: Aldehyde dehydrogenase family 8 member A1  
Size: 487 amino acids; 53401 Da
Sequence caution: Sequence=AAI14474.1; Type=Erroneous translation; Note=Wrong choice of CDS;
Secondary accessions: B7Z521 O60793 Q24JS9 Q53GT3 Q5TI80
Alternative splicing: 4 isoforms:  Q9H2A2-1   Q9H2A2-2   Q9H2A2-3   Q9H2A2-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ALDH8A1: NX_Q9H2A2

Explore proteomics data for ALDH8A1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 4 DME Specific Peptides for ALDH8A1 (Q9H2A2)
     NFRFFASS  GLVWTNCWL  EEIFGPVTCV  NQGEICLCTSRIFV 


    See ALDH8A1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001180409.1  NP_072090.1  NP_739577.1  

    ENSEMBL proteins: 
     ENSP00000265605   ENSP00000356819   ENSP00000325473   ENSP00000356821   ENSP00000437161  
     ENSP00000435297  

    ALDH8A1 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ALDH: Aldehyde dehydrogenases

    5 InterPro protein domains:
     IPR016163 Ald_DH_C
     IPR016162 Ald_DH_N
     IPR016161 Ald_DH/histidinol_DH
     IPR015590 Aldehyde_DH_dom
     IPR016160 Ald_DH_CS

    Graphical View of Domain Structure for InterPro Entry Q9H2A2

    ProtoNet protein and cluster: Q9H2A2

    1 Blocks protein domain: IPB002086 Aldehyde dehydrogenase

    UniProtKB/Swiss-Prot: AL8A1_HUMAN, Q9H2A2
    Similarity: Belongs to the aldehyde dehydrogenase family


    ALDH8A1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AL8A1_HUMAN, Q9H2A2
    Function: Converts 9-cis-retinal to 9-cis-retinoic acid. Has lower activity towards 13-cis-retinal. Has much lower
    activity towards all-trans-retinal. Has highest activity with benzaldehyde and decanal (in vitro). Has a
    preference for NAD, but shows considerable activity with NADP (in vitro)
    Biophysicochemical properties: Kinetic parameters: KM=17.5 uM for benzaldehyde; KM=3.15 uM for 9-cis-retinal; pH
    dependence: Optimum pH is 9;

         Enzyme Numbers (IUBMB): EC 1.2.12 EC 1.2.1.32 EC 1.2.1.-1

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001758retinal dehydrogenase activity IDA11007799
    GO:0016491oxidoreductase activity ----
    GO:0016620oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor ----
         
    ALDH8A1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ALDH8A1
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    miRNA
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    miRTarBase miRNAs that target ALDH8A1:
    hsa-mir-335-5p (MIRT018613)

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    6 qRT-PCR Assays for microRNAs that regulate ALDH8A1:
    hsa-miR-7-1* hsa-miR-7-2* hsa-let-7g* hsa-miR-3143 hsa-let-7a-2* hsa-miR-543
    SwitchGear 3'UTR luciferase reporter plasmidALDH8A1 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALDH8A1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    AL8A1_HUMAN, Q9H2A2: Cytoplasm (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IDA11007799
    GO:0005737cytoplasm IEA--
    GO:0070062extracellular vesicular exosome IDA19056867

    ALDH8A1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including ALDH8A1: 
              Drug Metabolism: Phase I Enzymes in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for ALDH8A1

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for ALDH8A1 (ENSP000002656054) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ZC3H14ENSP000002510384STRING: ENSP00000251038
    PRODHENSP000003495774STRING: ENSP00000349577
    G6PDENSP000003771924STRING: ENSP00000377192
    H6PDENSP000003666204STRING: ENSP00000366620
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008152metabolic process ----
    GO:0042573retinoic acid metabolic process IDA11007799
    GO:0042574retinal metabolic process IDA11007799
    GO:00429049-cis-retinoic acid biosynthetic process IEA--
    GO:0055114oxidation-reduction process ----

    ALDH8A1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ALDH8A1 (AL8A1)

    5 HMDB Compounds for ALDH8A1    About this table
    CompoundSynonyms CAS #PubMed Ids
    9-cis-Retinal9-cis-Retinal (see all 5)514-85-2--
    BenzaldehydeAlmond artificial essential oil (see all 30)100-52-7--
    DecanalN-decaldehyde (see all 18)112-31-2--
    NAD3-Carbamoyl-1-D-ribofuranosylpyridinium hydroxide 5'-ester with adenosine 5'-pyrophosphate (see all 28)53-84-9--
    NADPAdenine-nicotinamide dinucleotide phosphate (see all 18)53-59-8--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ALDH8A1 gene (3 alternative transcripts): 
    NM_001193480.1  NM_022568.3  NM_170771.2  

    Unigene Cluster for ALDH8A1:

    Aldehyde dehydrogenase 8 family, member A1
    Hs.486520  [show with all ESTs]
    Unigene Representative Sequence: NM_022568
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000265605(uc003qew.3 uc011ecx.2 uc003qex.3 uc010kgh.3)
    ENST00000367845 ENST00000349305 ENST00000367847 ENST00000460753 ENST00000534012

    miRNA
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    6 qRT-PCR Assays for microRNAs that regulate ALDH8A1:
    hsa-miR-7-1* hsa-miR-7-2* hsa-let-7g* hsa-miR-3143 hsa-let-7a-2* hsa-miR-543
    SwitchGear 3'UTR luciferase reporter plasmidALDH8A1 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat ALDH8A1

    Additional mRNA sequence: 

    AF303134.1 AK074266.1 AK222848.1 AK290784.1 AK298325.1 BC020849.1 BC113862.1 BC114473.1 
    BX647324.1 

    7 DOTS entries:

    DT.95256695  DT.308608  DT.101963494  DT.100751611  DT.91844195  DT.92418204  DT.40226263 

    Selected AceView cDNA sequences (see all 251):

    BC001465 BC040849 CA430319 AL137664 AJ459826 AB028961 AI333572 NM_170771 
    CR607684 AW270941 BQ232346 CB163504 CB215036 BF590919 AI624626 AI467869 
    CB162038 AW299988 BE463937 AW339594 Z41800 BG284613 BX647324 AW117894 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ALDH8A1    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c · 8d
    SP1:              -                                                     -                           
    SP2:              -                                   -     -     -     -                           
    SP3:                                                              -     -                           
    SP4:                                                                                                
    SP5:                                                                                                


    ECgene alternative splicing isoforms for ALDH8A1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ALDH8A1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ALDH8A1 Expression
    About this image

    ALDH8A1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ALDH8A1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.486520

    UniProtKB/Swiss-Prot: AL8A1_HUMAN, Q9H2A2
    Tissue specificity: Highly expressed in adult kidney and liver. Detected at lower levels in fetal liver and kidney

        Pathway & Disease-focused RT2 Profiler PCR Array including ALDH8A1: 
              Drug Metabolism: Phase I Enzymes in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALDH8A1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ALDH8A1 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Aldh8a11 , 5 aldehyde dehydrogenase 8 family, member A11, 5 85.42(n)1
    89.94(a)1
      10 (9.75 cM)5
    2373201  NM_178713.41  NP_848828.11 
     213772915 
    chicken
    (Gallus gallus)
    Aves ALDH8A11 aldehyde dehydrogenase 8 family, member A1 74.61(n)
    79.47(a)
      421695  XM_419732.3  XP_419732.1 
    lizard
    (Anolis carolinensis)
    Reptilia ALDH8A16
    aldehyde dehydrogenase 8 family, member A1
    78(a)
    1 ↔ 1
    GL343200.1(3239606-3268517)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.138562 Transcribed sequence with moderate similarity to protein more 74.02(n)    BX740972.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufi34g052 Transcribed sequence with moderate similarity to protein more 75.34(n)    CK027547.1 
    worm
    (Caenorhabditis elegans)
    Secernentea alh-101 alh-10 54.07(n)
    52.02(a)
      180979  NM_076802.4  NP_509203.1 
    rice
    (Oryza sativa)
    Liliopsida BU673735.12   -- 68.7(n)    BU673735.1 


    ENSEMBL Gene Tree for ALDH8A1 (if available)
    TreeFam Gene Tree for ALDH8A1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ALDH8A1 gene
    ALDH1L22  ALDH1A12  ENSG000002577672  ALDH1A22  ALDH1B12  ALDH7A12  ALDH6A12  ALDH22  
    ALDH9A12  ALDH1A32  ALDH1L12  
    11 SIMAP similar genes for ALDH8A1 using alignment to 3 protein entries:     AL8A1_HUMAN (see all proteins):
    ALDH9A1    ALDH1A1    ALDH1B1    ALDH2    ALDH1A2    ALDH1A3
    DKFZp686G1675    ALDH5A1    ALDH6A1    ALDH1L2    ALDH16A1

    ALDH8A1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ALDH8A1 (see all 792)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2007960571,2
    C--132823924(+) TTATTA/TTATTA 3 -- int10--------
    rs723866611,2
    C--132829386(+) TCATT-/TTTTG 
            
    TTTGT
    3 -- int10--------
    rs791472631,2
    C--132829408(+) GTTTT-/G/    
       GTTTT
    TTAGA
    3 -- int10--------
    rs1140226011,2
    C,F--135238129(+) GCTTTG/CGACAC 3 -- ds50011Minor allele frequency- C:0.23WA 118
    rs1139313161,2
    C,F--135238139(+) CTCCTG/ATCCAG 3 -- ds50013Minor allele frequency- A:0.05CSA WA 122
    rs1178838991,2
    F--135238160(+) AGACAT/GGCAAA 3 -- ds50011Minor allele frequency- G:0.03NA 120
    rs1419620221,2
    --135238222(+) TGCTCC/GGCCAC 3 -- ds50010--------
    rs1146494361,2
    C,F--135238253(+) GAGGTG/AGGTAG 3 -- ds50011Minor allele frequency- A:0.08WA 118
    rs717431681,2
    C--135238422(+) AAAAA-/AAAA  
            
    GCATT
    3 -- ds50010--------
    rs94941161,2
    C,F,H--135238428(+) ACCCTG/ACCTCT 3 -- ds50017Minor allele frequency- A:0.09NS EA NA CSA WA 542

    HapMap Linkage Disequilibrium report for ALDH8A1 (135238528 - 135271260 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ALDH8A1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv5489CNV Loss18451855
    nsv886683CNV Loss21882294
    nsv464063CNV Gain19166990

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606467    OMIM disorders: --

    4 diseases for ALDH8A1:    
    About MalaCards
    sjogren-larsson syndrome    retinitis    beta thalassemia    thalassemia


    ALDH8A1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ALDH8A1
    Human Genome Epidemiology (HuGE) Navigator: ALDH8A1 (1 document)

    Export disorders for ALDH8A1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ALDH8A1 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with ALDH8A1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning and expression of a human aldehyde dehydrogenase (ALDH) active with 9-cis-retinal and identification of a rat ortholog, ALDH12. (PubMed id 11007799)1, 2, 3, 9 Lin M. and Napoli J.L. (J. Biol. Chem. 2000)
    2. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PubMed id 19343046)1, 4 Saito A....Kamatani N. (J. Hum. Genet. 2009)
    3. Genetics of coronary artery calcification among African Americans, a meta-analysis. (PubMed id 23870195)1 Wojczynski M.K....Reilly M.P. (BMC Med. Genet. 2013)
    4. A whole genome screen for HIV restriction factors. (PubMed id 22082156)1 Liu L....McKnight A. (Retrovirology 2011)
    5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    6. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PubMed id 19056867)1 Gonzales P.A....Knepper M.A. (J. Am. Soc. Nephrol. 2009)
    7. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)2 Mungall A.J.... Beck S. (Nature 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 64577 HGNC: 15471 AceView: HBS1LandALDH8A1 Ensembl:ENSG00000118514 euGenes: HUgn64577
    ECgene: ALDH8A1 H-InvDB: ALDH8A1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ALDH8A1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ALDH8A1 gene:
    Search GeneIP for patents involving ALDH8A1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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