Aliases for ALDH8A1 Gene
External Ids for ALDH8A1 Gene
Previous GeneCards Identifiers for ALDH8A1 Gene
This protein belongs to the aldehyde dehydrogenases family of proteins. It plays a role in a pathway of 9-cis-retinoic acid biosynthesis in vivo. This enzyme converts 9-cis-retinal into the retinoid X receptor ligand 9-cis-retinoic acid, and has approximately 40-fold higher activity with 9-cis-retinal than with all-trans-retinal. Therefore, it is the first known aldehyde dehydrogenase to show a preference for 9-cis-retinal relative to all-trans-retinal. Three transcript variants encoding distinct protein isoforms have been identified for this gene. [provided by RefSeq, Jul 2010]
GeneCards Summary for ALDH8A1 Gene
ALDH8A1 (Aldehyde Dehydrogenase 8 Family, Member A1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by Retinoic Acid. GO annotations related to this gene include oxidoreductase activity and oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor. An important paralog of this gene is ALDH1A2.
UniProtKB/Swiss-Prot for ALDH8A1 Gene
Converts 9-cis-retinal to 9-cis-retinoic acid. Has lower activity towards 13-cis-retinal. Has much lower activity towards all-trans-retinal. Has highest activity with benzaldehyde and decanal (in vitro). Has a preference for NAD, but shows considerable activity with NADP (in vitro).