ALDH4A1 Gene
protein-coding GIFtS: 64
GCID: GC01M019197
|
|
aldehyde dehydrogenase 4 family, member A1
(Previous symbol: ALDH4)
| |
Aliases
for ALDH4A1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Aldehyde Dehydrogenase 4 Family, Member A11 2 | | EC 1.5.1.123 8 | | ALDH41 2 3 5 | | P5CDH3 5 | | P5CDh1 2 | | P5CD2 | | Aldehyde Dehydrogenase Family 4 Member A12 3 | | Delta-1-Pyrroline-5-Carboxylate Dehydrogenase, Mitochondrial2 | | P5C Dehydrogenase2 3 | | Mitochondrial Delta-1-Pyrroline 5-Carboxylate Dehydrogenase2 |
Export aliases for ALDH4A1 gene to outside databasesPrevious GC identifers: GC01U990216 GC01M018343 GC01M018667 GC01M018943 GC01M019070 GC01M019181 GC01M017442 |
Summaries
for ALDH4A1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ALDH4A1:
This protein belongs to the aldehyde dehydrogenase family of proteins. This enzyme is a mitochondrial matrixNAD-dependent dehydrogenase which catalyzes the second step of the proline degradation pathway, convertingpyrroline-5-carboxylate to glutamate. Deficiency of this enzyme is associated with type II hyperprolinemia, anautosomal recessive disorder characterized by accumulation of delta-1-pyrroline-5-carboxylate (P5C) and proline.Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. (provided byRefSeq, Jun 2009)
UniProtKB/Swiss-Prot: AL4A1_HUMAN, P30038Function: Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine,to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. Thepreferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipicsemialdehydes
Gene Wiki entry for ALDH4A1 (Aldehyde dehydrogenase 4 family, member A1)
|
Genomic Views
for ALDH4A1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004610.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ALDH4A1 gene promoter:
HOXA9B HOXA9 TBP Brachyury AREB6 c-Rel TFIID Meis-1a Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for ALDH4A1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ALDH4A1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p36 Ensembl cytogenetic band: 1p36.13 HGNC cytogenetic band: 1p36ALDH4A1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M019197: view genomic region
(about GC identifiers)
Start:
|
19,197,924 bp from pter |
End:
|
19,229,293 bp from pter |
Size:
|
31,370 bases |
Orientation:
|
minus strand |
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Proteins
for ALDH4A1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: AL4A1_HUMAN, P30038 (See
protein sequence)Recommended Name: Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial precursor Size: 563 amino acids; 61719 Da
Subunit: Homodimer
Subcellular location: Mitochondrion matrix
3 PDB 3D structures from  and Proteopedia  for ALDH4A1:3V9G (3D)
3V9H (3D)
3V9I (3D)
Secondary accessions: A8K1Q7 B4DGE4 Q16882 Q53HU4 Q5JNV6 Q8IZ38 Q96IF0 Q9UDI6Alternative splicing: 2 isoforms: P30038-1 P30038-2 Explore the universe of human proteins at neXtProt for ALDH4A1: NX_P30038
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P30038
4/17 DME Specific Peptides for ALDH4A1 (P30038) (see all 17)
ALDH4A1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001154976.1 NP_003739.2 NP_733844.1
ENSEMBL proteins: ENSP00000290597 ENSP00000364490 ENSP00000393209 ENSP00000446071 ENSP00000442988 Reactome Protein details: P30038
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005739 | mitochondrion |
-- | -- | | GO:0005759 | mitochondrial matrix |
TAS | -- |
ALDH4A1 for ontologies About GeneDecksing
ALDH4A1 Antibody Products:
Assay Products for ALDH4A1: |
Protein
Domains /
Families
for ALDH4A1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ALDH4A1 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry P30038ProtoNet protein and cluster: P30038 1 Blocks protein family: IPB002086 Aldehyde dehydrogenase
UniProtKB/Swiss-Prot: AL4A1_HUMAN, P30038Similarity: Belongs to the aldehyde dehydrogenase family |
Function
for ALDH4A1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: AL4A1_HUMAN, P30038Function: Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine,to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. Thepreferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipicsemialdehydesCatalytic activity: (S)-1-pyrroline-5-carboxylate + NAD(P)(+) + 2 H(2)O = L-glutamate + NAD(P)HBiophysicochemical properties: Kinetic parameters: KM=100 uM for NAD; KM=32 uM for L-pyrroline-5-carboxylate;Enzyme Number (IUBMB): EC 1.5.1.121 2
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ALDH4A1 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ALDH4A1 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): ALDH4A1 (NM_003748) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ALDH4A1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALDH4A1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALDH4A1 |
Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003842 | 1-pyrroline-5-carboxylate dehydrogenase activity |
EXP | -- | | GO:0004029 | aldehyde dehydrogenase (NAD) activity |
TAS | 8621661 | | GO:0009055 | electron carrier activity |
TAS | 8621661 | | GO:0016491 | oxidoreductase activity |
-- | -- | | GO:0016620 | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
-- | -- |
ALDH4A1 for ontologies About GeneDecksing
4 GenomeRNAi human phenotypes for ALDH4A1:
|
Pathways & Interactions
for ALDH4A1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | proline degradation | | | 2 | Metabolism | | | 3 | Metabolism of amino acids and derivatives | | | 4 | Arginine and proline metabolism | | | 5 | Alanine, aspartate and glutamate metabolism | |
Pathway sources
See GeneCards unified pathways
Show all pathways
3  BioSystems Pathways for ALDH4A1
3 
Reactome Pathways for ALDH4A1
3 
Kegg Pathways (Kegg details for ALDH4A1):
UniProtKB/Swiss-Prot: AL4A1_HUMAN, P30038Pathway: Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 2/2
ALDH4A1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ALDH4A1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/51 Interacting proteins for ALDH4A1 (P300381, 3 ENSP000002905974) via UniProtKB, MINT, STRING, and/or I2D (see all 51)
About this table
Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table
ALDH4A1 for ontologies About GeneDecksing
|
Drugs & Compounds
for ALDH4A1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
ALDH4A1 for compounds About GeneDecksing
 Browse Tocris compounds for ALDH4A1
10/12 HMDB Compounds for ALDH4A1 (see all 12) About this table
1 DrugBank Compound for ALDH4A1 About this table
4 Novoseek chemical compound relationships for ALDH4A1 gene About this table
Search CenterWatch for drugs/clinical trials and news about ALDH4A1 / AL4A1
|
Transcripts
for ALDH4A1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ALDH4A1 gene (3 alternative transcripts): NM_001161504.1 NM_003748.3 NM_170726.2 Unigene Cluster for ALDH4A1: Aldehyde dehydrogenase 4 family, member A1 Hs.77448 [show with all ESTs]Unigene Representative Sequence: NM_0037486 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000290597 ENST00000375341(uc001bbb.3 uc001bbc.3 uc021ohl.1)
ENST00000454547 ENST00000432718 ENST00000538839 ENST00000538309(uc010ocu.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ALDH4A1 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ALDH4A1 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): ALDH4A1 (NM_003748) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ALDH4A1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALDH4A1 |
Additional cDNA sequence: AK222486.1 AK289972.1 AK294552.1 BC007581.1 BC023600.2 FJ462711.1 U24266.1 U24267.1 12 DOTS entries: DT.447304 DT.100684300 DT.101984174 DT.100780395 DT.95277958 DT.121335877 DT.100679216 DT.100843318 DT.100722280 DT.100742055 DT.100780393 DT.121335857 24/206 AceView cDNA sequences (see all 206): BX397598 BM827731 BM666786 CD617447 AA937730 AI346540 CA397801 BC007581 BQ083021 BM663173 BG769561 BM834527 BM767132 BQ053821 CA433992 AI268983 CD617448 AW571937 BQ954843 BC023600 BU509005 BM664288 AA679563 BM857316
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for ALDH4A1 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ALDH4A1
|
Expression
for ALDH4A1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ALDH4A1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGGGGCCGGG
About this image
See ALDH4A1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ALDH4A1
SOURCE GeneReport for Unigene cluster: Hs.77448
UniProtKB/Swiss-Prot: AL4A1_HUMAN, P30038Tissue specificity: Highest expression is found in liver followed by skeletal muscle, kidney, heart, brain, placenta,lung and pancreas
SABiosciences Expression via Pathway-Focused PCR Arrays including ALDH4A1:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ALDH4A1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ALDH4A1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ALDH4A1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ALDH4A1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALDH4A1 |
Orthologs
for ALDH4A1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals and fungi.
Orthologs for ALDH4A1 gene from 5/28 species (see all 28) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
ALDH4A11 |
aldehyde dehydrogenase 4 family, member A1 |
78.38(n)
79.96(a) |
|
419467 NM_001252104.1 NP_001239033.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc635922 |
similar to aldehyde dehydrogenase 4 family, member more |
75.19(n) |
|
394133 BC055155.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG71453
P5CDh11 |
1-pyrroline-5-carboxylate dehydrogenase3
delta-1-Pyrroline-5-carboxylate dehydrogenase 11 |
61(a)3
64.4(n)1
61.89(a)1 |
|
78F43
404341 NM_168945.41 NP_730698.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
alh-61 |
Protein ALH-6 |
57.83(n)
56.2(a) |
|
173510 NM_061545.5 NP_493946.1 |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
PUT2(YHR037W)4
PUT21 |
Delta-1-pyrroline-5-carboxylate dehydrogenase, nuclear-encoded more4
Put2p1 |
46.28(n)1
43.94(a)1 |
|
8(181977-183704)4
8564321, 4 NP_011902.11, 4 |
ENSEMBL Gene Tree for ALDH4A1 (if available)
TreeFam Gene Tree for ALDH4A1 (if available) |
Paralogs
for ALDH4A1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for ALDH4A1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ALDH4A1 (19197924 - 19229293 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ALDH4A1: --
Human Gene Mutation Database (HGMD): ALDH4A1
Locus Specific Mutation Databases (LSDB): ALDH4A1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ALDH4A1 |
|
Disorders
/ Diseases
for ALDH4A1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ALDH4A1 for disorders About GeneDecksing
OMIM gene information: 606811
OMIM disorders: 239510
UniProtKB/Swiss-Prot: AL4A1_HUMAN, P30038
Defects in ALDH4A1 are the cause of hyperprolinemia type 2 (HP-2) [MIM:239510]. HP-2 is characterized by theaccumulation of delta-1-pyrroline-5-carboxylate (P5C) and proline. The disorder may be causally related to neurologicmanifestations, including seizures and mental retardation
8  diseases for ALDH4A1: About MalaCardshyperprolinemia hyperprolinemia type 2 hearing loss acne
esophagitis tuberculosis adenocarcinoma mycobacterium tuberculosis
1 disease from the University of Copenhagen DISEASES database for ALDH4A1:Succinic semialdehyde dehydrogenase deficiency 1 Novoseek disease relationship for ALDH4A1 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| hyperprolinemia, type ii |
97 |
1 |
16934832 (1) |
Human Genome Epidemiology (HuGE) Navigator: ALDH4A1 (3 documents)
Export disorders for ALDH4A1 gene to outside databases
|
Publications
for ALDH4A1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ALDH4A1 gene, integrated from 9 sources (see all 32):
(articles sorted by number of sources associating them with ALDH4A1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning, characterization, and expression of cDNAs encoding human delta 1-pyrroline-5-carboxylate dehydrogenase. (PubMed id 8621661)1, 2, 3, 9 Hu C.-A.... Valle D. (1996)
- The three-dimensional structural basis of type II hype rprolinemia. (PubMed id 22516612)1, 2 Srivastava D....Tanner J.J. (2012)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Mutations in the Delta1-pyrroline 5-carboxylate dehydrogenase gene cause type II hyperprolinemia. (PubMed id 9700195)1, 2 Geraghty M.T.... Hu C.-A.A. (1998)
- Human liver protein map: a reference database established by microsequencing and gel comparison. (PubMed id 1286669)1, 2 Hochstrasser D.F.... Hughes G.J. (1992)
- Identification of ALDH4 as a p53-inducible gene and its protective role in cellular stresses. (PubMed id 14986171)1, 9 Yoon K.A....Arakawa H. (2004)
- Crystal structure of Thermus thermophilus Delta1-pyrroline-5-carboxylate dehydrogenase. (PubMed id 16934832)7, 9 Inagaki E....Tahirov T.H. (2006)
- Human liver high Km aldehyde dehydrogenase (ALDH4): properties and structural relationship to the glutamic gamma-semialdehyde dehydrogenase. (PubMed id 8493898)2, 9 Agarwal D.P.... Goedde H.W. (1993)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
|
External Searches for ALDH4A1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ALDH4A1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ALDH4A1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ALDH4A1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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| Name | Description |
| PharmGKB entry for ALDH4A1 | Pharmacogenomics, SNPs, Pathways | | GeneReviews | http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/ALDH4A1 |
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About This Section
| Patent Information for ALDH4A1 gene:
Search GeneIP for patents involving ALDH4A1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for ALDH4A1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ALDH4A1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ALDH4A1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ALDH4A1 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ALDH4A1 | | OriGene 3'-UTR Clone for ALDH4A1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ALDH4A1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ALDH4A1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for ALDH4A1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ALDH4A1 | | OriGene Custom Protein Services for ALDH4A1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ALDH4A1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ALDH4A1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ALDH4A1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ALDH4A1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ALDH4A1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ALDH4A1 |
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| | | | Search Tocris compounds for ALDH4A1 |
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 | | | ALDH4A1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALDH4A1 |
|  |  |  | | | | ThermoFisher Antibodies for ALDH4A1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALDH4A1 |
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