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Aliases for ALDH3B2 Gene

Aliases for ALDH3B2 Gene

  • Aldehyde Dehydrogenase 3 Family Member B2 2 3 5
  • Aldehyde Dehydrogenase 8 2 3 4
  • Acetaldehyde Dehydrogenase 8 2 3
  • EC 1.2.1.5 4 61
  • ALDH8 3 4
  • Aldehyde Dehydrogenase 3 Family, Member B2 2
  • Aldehyde Dehydrogenase Family 3 Member B2 3
  • EC 1.2.1 61

External Ids for ALDH3B2 Gene

Previous HGNC Symbols for ALDH3B2 Gene

  • ALDH8

Previous GeneCards Identifiers for ALDH3B2 Gene

  • GC11M069952
  • GC11M069125
  • GC11M067679
  • GC11M067204
  • GC11M067186
  • GC11M067429
  • GC11M063759

Summaries for ALDH3B2 Gene

Entrez Gene Summary for ALDH3B2 Gene

  • This gene encodes a member of the aldehyde dehydrogenase family, a group of isozymes that may play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. The gene of this particular family member is over 10 kb in length. The expression of these transcripts is restricted to the salivary gland among the human tissues examined. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for ALDH3B2 Gene

ALDH3B2 (Aldehyde Dehydrogenase 3 Family Member B2) is a Protein Coding gene. Among its related pathways are 2-deoxy-alpha-D-ribose 1-phosphate degradation and beta-Alanine metabolism (KEGG). GO annotations related to this gene include oxidoreductase activity and 3-chloroallyl aldehyde dehydrogenase activity. An important paralog of this gene is ALDH3B1.

UniProtKB/Swiss-Prot for ALDH3B2 Gene

  • Oxidizes medium and long chain aldehydes into non-toxic fatty acids.

Gene Wiki entry for ALDH3B2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ALDH3B2 Gene

Genomics for ALDH3B2 Gene

Regulatory Elements for ALDH3B2 Gene

Enhancers for ALDH3B2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around ALDH3B2 on UCSC Golden Path with GeneCards custom track

Genomic Location for ALDH3B2 Gene

Chromosome:
11
Start:
67,662,155 bp from pter
End:
67,681,214 bp from pter
Size:
19,060 bases
Orientation:
Minus strand

Genomic View for ALDH3B2 Gene

Genes around ALDH3B2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ALDH3B2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ALDH3B2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ALDH3B2 Gene

Proteins for ALDH3B2 Gene

  • Protein details for ALDH3B2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P48448-AL3B2_HUMAN
    Recommended name:
    Aldehyde dehydrogenase family 3 member B2
    Protein Accession:
    P48448
    Secondary Accessions:
    • Q53Y98
    • Q8NAL5
    • Q96IB2

    Protein attributes for ALDH3B2 Gene

    Size:
    385 amino acids
    Molecular mass:
    42635 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ALDH3B2 Gene

Selected DME Specific Peptides for ALDH3B2 Gene

Post-translational modifications for ALDH3B2 Gene

  • Geranylgeranylation is important for localization to lipid droplets and enzyme activity.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ALDH3B2 Gene

Domains & Families for ALDH3B2 Gene

Gene Families for ALDH3B2 Gene

Protein Domains for ALDH3B2 Gene

Suggested Antigen Peptide Sequences for ALDH3B2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P48448

UniProtKB/Swiss-Prot:

AL3B2_HUMAN :
  • Belongs to the aldehyde dehydrogenase family.
Family:
  • Belongs to the aldehyde dehydrogenase family.
genes like me logo Genes that share domains with ALDH3B2: view

Function for ALDH3B2 Gene

Molecular function for ALDH3B2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
An aldehyde + NAD(P)(+) + H(2)O = a carboxylate + NAD(P)H.
UniProtKB/Swiss-Prot Function:
Oxidizes medium and long chain aldehydes into non-toxic fatty acids.

Enzyme Numbers (IUBMB) for ALDH3B2 Gene

Gene Ontology (GO) - Molecular Function for ALDH3B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004028 3-chloroallyl aldehyde dehydrogenase activity TAS 8890755
GO:0004029 aldehyde dehydrogenase (NAD) activity IBA --
GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity EXP 25286108
genes like me logo Genes that share ontologies with ALDH3B2: view
genes like me logo Genes that share phenotypes with ALDH3B2: view

Animal Model Products

CRISPR Products

miRNA for ALDH3B2 Gene

miRTarBase miRNAs that target ALDH3B2

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ALDH3B2 Gene

Localization for ALDH3B2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ALDH3B2 Gene

Lipid droplet.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ALDH3B2 Gene COMPARTMENTS Subcellular localization image for ALDH3B2 gene
Compartment Confidence
extracellular 2
plasma membrane 2
chloroplast 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for ALDH3B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005811 lipid particle TAS --
genes like me logo Genes that share ontologies with ALDH3B2: view

Pathways & Interactions for ALDH3B2 Gene

genes like me logo Genes that share pathways with ALDH3B2: view

UniProtKB/Swiss-Prot P48448-AL3B2_HUMAN

  • Pathway: Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2.

Interacting Proteins for ALDH3B2 Gene

Gene Ontology (GO) - Biological Process for ALDH3B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006066 alcohol metabolic process TAS 8890755
GO:0006068 ethanol catabolic process IEA --
GO:0006629 lipid metabolic process TAS 8890755
GO:0030148 sphingolipid biosynthetic process TAS --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with ALDH3B2: view

No data available for SIGNOR curated interactions for ALDH3B2 Gene

Drugs & Compounds for ALDH3B2 Gene

(10) Drugs for ALDH3B2 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Chloral hydrate Approved, Illicit, Vet_approved Pharma 14
phenylacetic acid Approved Pharma 11
Water Approved Pharma 0
acetic acid Approved Nutra Full agonist, Agonist 101
3,4-Dihydroxybenzeneacetic acid Experimental Pharma 0

(20) Additional Compounds for ALDH3B2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
3,4-Dihydroxymandelaldehyde
  • 3,4-Dihydroxyphenylglycolaldehyde
  • 3,4-Dihydroxyphenylglycolic aldehyde
  • a,3,4-Trihydroxy-Benzeneacetaldehyde
  • alpha,3,4-Trihydroxy-Benzeneacetaldehyde
13023-73-9
3,4-Dihydroxymandelic acid
  • 3,4 Dihydroxymandelate
  • 3,4 Dihydroxymandelic acid
  • 3,4-Dihydroxymandelate
  • 3,4-Dihydroxyphenylglycolate
  • 3,4-Dihydroxyphenylglycolic acid
775-01-9
3,4-Dihydroxyphenylacetaldehyde
  • 3,4-Dihydroxy-Benzeneacetaldehyde
  • Protocatechuatealdehyde
5707-55-1
3-Aminopropionaldehyde
  • 3-Aminopropanal
  • 3-Aminopropionaldehyde
  • beta-Aminopropion aldehyde
352-92-1
3-Carbamoyl-2-phenylpropionaldehyde
genes like me logo Genes that share compounds with ALDH3B2: view

Transcripts for ALDH3B2 Gene

Unigene Clusters for ALDH3B2 Gene

Aldehyde dehydrogenase 3 family, member B2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ALDH3B2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13
SP1: - - - -
SP2:
SP3: -
SP4: - - -
SP5:

Relevant External Links for ALDH3B2 Gene

GeneLoc Exon Structure for
ALDH3B2
ECgene alternative splicing isoforms for
ALDH3B2

Expression for ALDH3B2 Gene

mRNA expression in normal human tissues for ALDH3B2 Gene

mRNA differential expression in normal tissues according to GTEx for ALDH3B2 Gene

This gene is overexpressed in Esophagus - Mucosa (x16.8), Skin - Sun Exposed (Lower leg) (x12.4), and Skin - Not Sun Exposed (Suprapubic) (x12.0).

Protein differential expression in normal tissues from HIPED for ALDH3B2 Gene

This gene is overexpressed in Lung (53.5) and Heart (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ALDH3B2 Gene



Protein tissue co-expression partners for ALDH3B2 Gene

NURSA nuclear receptor signaling pathways regulating expression of ALDH3B2 Gene:

ALDH3B2

SOURCE GeneReport for Unigene cluster for ALDH3B2 Gene:

Hs.87539

mRNA Expression by UniProt/SwissProt for ALDH3B2 Gene:

P48448-AL3B2_HUMAN
Tissue specificity: Salivary gland.
genes like me logo Genes that share expression patterns with ALDH3B2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for ALDH3B2 Gene

Orthologs for ALDH3B2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ALDH3B2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ALDH3B2 35
  • 66 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ALDH3B2 35
  • 55 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 36 (a)
OneToMany
mouse
(Mus musculus)
Mammalia 1700055N04Rik 35
  • 63 (a)
OneToMany
Aldh3b2 35
  • 65 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia ALDH3B2 35
  • 96 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 35
  • 48 (a)
ManyToMany
-- 35
  • 48 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 46 (a)
ManyToMany
-- 35
  • 46 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii -- 34
aldh3b1 35
  • 44 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Aldh-III 36
  • 53 (a)
Aldh-III 35
  • 35 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea alh-4 35
  • 34 (a)
ManyToMany
alh-5 35
  • 35 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HFD1 35
  • 25 (a)
OneToMany
corn
(Zea mays)
Liliopsida Zm.17294 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6683 35
  • 34 (a)
ManyToMany
CSA.9635 35
  • 33 (a)
ManyToMany
Species where no ortholog for ALDH3B2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ALDH3B2 Gene

ENSEMBL:
Gene Tree for ALDH3B2 (if available)
TreeFam:
Gene Tree for ALDH3B2 (if available)

Paralogs for ALDH3B2 Gene

Paralogs for ALDH3B2 Gene

(5) SIMAP similar genes for ALDH3B2 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for ALDH3B2 Gene

genes like me logo Genes that share paralogs with ALDH3B2: view

Variants for ALDH3B2 Gene

Sequence variations from dbSNP and Humsavar for ALDH3B2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs3741178 - 67,666,577(+) ACCTG(C/T)GGCGA reference, missense
rs4646826 - 67,663,729(-) AGCAG(A/C/T)GGCAG intron-variant, reference, missense
rs1551888 - 67,666,398(+) CGCAA(C/T)TCCCT reference, missense
rs6591270 - 67,665,383(+) TGATG(C/T)GGCCC reference, missense
rs2447571 - 67,665,333(+) GCGGC(C/T)GCAGC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ALDH3B2 Gene

Variant ID Type Subtype PubMed ID
dgv1214n100 CNV gain 25217958
dgv142e201 CNV deletion 23290073
dgv154n27 CNV loss 19166990
dgv1981n54 CNV gain 21841781
dgv1982n54 CNV loss 21841781
esv1206079 CNV deletion 17803354
esv2179266 CNV deletion 18987734
esv2422195 CNV duplication 17116639
esv2662033 CNV deletion 23128226
esv27185 CNV loss 19812545
esv2744645 CNV deletion 23290073
esv2744646 CNV deletion 23290073
esv2744648 CNV deletion 23290073
esv2744649 CNV deletion 23290073
esv3626717 CNV loss 21293372
nsv1078326 CNV duplication 25765185
nsv1141197 CNV duplication 24896259
nsv468606 CNV gain 19166990
nsv468609 CNV loss 19166990
nsv469963 CNV loss 18288195
nsv555273 CNV loss 21841781
nsv555274 CNV gain 21841781
nsv951024 CNV deletion 24416366

Variation tolerance for ALDH3B2 Gene

Residual Variation Intolerance Score: 99.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.59; 78.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ALDH3B2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ALDH3B2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ALDH3B2 Gene

Disorders for ALDH3B2 Gene

Relevant External Links for ALDH3B2

Genetic Association Database (GAD)
ALDH3B2
Human Genome Epidemiology (HuGE) Navigator
ALDH3B2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ALDH3B2

No disorders were found for ALDH3B2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ALDH3B2 Gene

Publications for ALDH3B2 Gene

  1. Sequencing and expression of the human ALDH8 encoding a new member of the aldehyde dehydrogenase family. (PMID: 8890755) Hsu L.C. … Chang W.-C. (Gene 1996) 2 3 4 65
  2. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PMID: 19343046) Saito A. … Kamatani N. (J. Hum. Genet. 2009) 3 46 65
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  5. Human aldehyde dehydrogenase genes, ALDH7 and ALDH8: genomic organization and gene structure comparison. (PMID: 9161417) Hsu L.C. … Yoshida A. (Gene 1997) 2 3 65

Products for ALDH3B2 Gene

Sources for ALDH3B2 Gene

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