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Aliases for ALDH3B2 Gene

Aliases for ALDH3B2 Gene

  • Aldehyde Dehydrogenase 3 Family, Member B2 2 3
  • Aldehyde Dehydrogenase 8 2 3 4
  • Acetaldehyde Dehydrogenase 8 2 3
  • EC 1.2.1.5 4 63
  • ALDH8 3 4
  • EC 1.2.1 63

External Ids for ALDH3B2 Gene

Previous HGNC Symbols for ALDH3B2 Gene

  • ALDH8

Previous GeneCards Identifiers for ALDH3B2 Gene

  • GC11M069952
  • GC11M069125
  • GC11M067679
  • GC11M067204
  • GC11M067186
  • GC11M067429
  • GC11M063759

Summaries for ALDH3B2 Gene

Entrez Gene Summary for ALDH3B2 Gene

  • This gene encodes a member of the aldehyde dehydrogenase family, a group of isozymes that may play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. The gene of this particular family member is over 10 kb in length. The expression of these transcripts is restricted to the salivary gland among the human tissues examined. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for ALDH3B2 Gene

ALDH3B2 (Aldehyde Dehydrogenase 3 Family, Member B2) is a Protein Coding gene. Among its related pathways are Metabolism and Chemical carcinogenesis. GO annotations related to this gene include oxidoreductase activity and 3-chloroallyl aldehyde dehydrogenase activity. An important paralog of this gene is ALDH3A1.

Gene Wiki entry for ALDH3B2 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ALDH3B2 Gene

Genomics for ALDH3B2 Gene

Regulatory Elements for ALDH3B2 Gene

Genomic Location for ALDH3B2 Gene

Chromosome:
11
Start:
67,662,155 bp from pter
End:
67,681,214 bp from pter
Size:
19,060 bases
Orientation:
Minus strand

Genomic View for ALDH3B2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ALDH3B2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ALDH3B2 Gene

Proteins for ALDH3B2 Gene

  • Protein details for ALDH3B2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P48448-AL3B2_HUMAN
    Recommended name:
    Aldehyde dehydrogenase family 3 member B2
    Protein Accession:
    P48448
    Secondary Accessions:
    • Q53Y98
    • Q8NAL5
    • Q96IB2

    Protein attributes for ALDH3B2 Gene

    Size:
    385 amino acids
    Molecular mass:
    42635 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ALDH3B2 Gene

Proteomics data for ALDH3B2 Gene at MOPED

Selected DME Specific Peptides for ALDH3B2 Gene

Post-translational modifications for ALDH3B2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ALDH3B2 Gene

Domains & Families for ALDH3B2 Gene

Gene Families for ALDH3B2 Gene

Protein Domains for ALDH3B2 Gene

Suggested Antigen Peptide Sequences for ALDH3B2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P48448

UniProtKB/Swiss-Prot:

AL3B2_HUMAN :
  • Belongs to the aldehyde dehydrogenase family.
Family:
  • Belongs to the aldehyde dehydrogenase family.
genes like me logo Genes that share domains with ALDH3B2: view

Function for ALDH3B2 Gene

Molecular function for ALDH3B2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
An aldehyde + NAD(P)(+) + H(2)O = a carboxylate + NAD(P)H

Enzyme Numbers (IUBMB) for ALDH3B2 Gene

Gene Ontology (GO) - Molecular Function for ALDH3B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004028 3-chloroallyl aldehyde dehydrogenase activity TAS 8890755
GO:0004029 aldehyde dehydrogenase (NAD) activity IBA --
GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity IEA --
GO:0016491 oxidoreductase activity --
genes like me logo Genes that share ontologies with ALDH3B2: view
genes like me logo Genes that share phenotypes with ALDH3B2: view

Animal Model Products

CRISPR Products

miRNA for ALDH3B2 Gene

miRTarBase miRNAs that target ALDH3B2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ALDH3B2

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for ALDH3B2 Gene

Localization for ALDH3B2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ALDH3B2 Gene COMPARTMENTS Subcellular localization image for ALDH3B2 gene
Compartment Confidence
chloroplast 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ALDH3B2 Gene

Pathways & Interactions for ALDH3B2 Gene

genes like me logo Genes that share pathways with ALDH3B2: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Drug Metabolism: Phase I Enzymes in human,mouse,rat

UniProtKB/Swiss-Prot P48448-AL3B2_HUMAN

  • Pathway: Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2

Interacting Proteins for ALDH3B2 Gene

Gene Ontology (GO) - Biological Process for ALDH3B2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006066 alcohol metabolic process TAS 8890755
GO:0006068 ethanol catabolic process IEA --
GO:0006629 lipid metabolic process TAS 8890755
GO:0008152 metabolic process --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with ALDH3B2: view

No data available for SIGNOR curated interactions for ALDH3B2 Gene

Drugs & Compounds for ALDH3B2 Gene

(9) Drugs for ALDH3B2 Gene - From: HMDB and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
acetic acid Approved Nutra Full agonist, Agonist 80
3,4-Dihydroxybenzeneacetic acid Experimental Pharma 0
beta-Alanine Experimental Pharma Full agonist, Agonist Endogenous glycine agonist, more selective than taurine (Cat. No. 0209) 0
Chloral hydrate Experimental, Illicit Pharma 14
Phenylacetaldehyde Experimental Pharma 0

(21) Additional Compounds for ALDH3B2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
3,4-Dihydroxymandelaldehyde
  • 3,4-Dihydroxyphenylglycolaldehyde
  • 3,4-Dihydroxyphenylglycolic aldehyde
  • a,3,4-Trihydroxy-Benzeneacetaldehyde
  • alpha,3,4-Trihydroxy-Benzeneacetaldehyde
13023-73-9
3,4-Dihydroxymandelic acid
  • 3,4 Dihydroxymandelate
  • 3,4 Dihydroxymandelic acid
  • 3,4-Dihydroxymandelate
  • 3,4-Dihydroxyphenylglycolate
  • 3,4-Dihydroxyphenylglycolic acid
775-01-9
3,4-Dihydroxyphenylacetaldehyde
  • 3,4-Dihydroxy-Benzeneacetaldehyde
  • Protocatechuatealdehyde
5707-55-1
3-Aminopropionaldehyde
  • 3-Aminopropanal
  • 3-Aminopropionaldehyde
  • beta-Aminopropion aldehyde
352-92-1
3-Carbamoyl-2-phenylpropionaldehyde
genes like me logo Genes that share compounds with ALDH3B2: view

Transcripts for ALDH3B2 Gene

Unigene Clusters for ALDH3B2 Gene

Aldehyde dehydrogenase 3 family, member B2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ALDH3B2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ALDH3B2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13
SP1: - - - -
SP2:
SP3: -
SP4: - - -
SP5:

Relevant External Links for ALDH3B2 Gene

GeneLoc Exon Structure for
ALDH3B2
ECgene alternative splicing isoforms for
ALDH3B2

Expression for ALDH3B2 Gene

mRNA expression in normal human tissues for ALDH3B2 Gene

mRNA differential expression in normal tissues according to GTEx for ALDH3B2 Gene

This gene is overexpressed in Esophagus - Mucosa (x16.8), Skin - Sun Exposed (Lower leg) (x12.4), and Skin - Not Sun Exposed (Suprapubic) (x12.0).

Protein differential expression in normal tissues from HIPED for ALDH3B2 Gene

This gene is overexpressed in Lung (53.5) and Heart (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ALDH3B2 Gene



SOURCE GeneReport for Unigene cluster for ALDH3B2 Gene Hs.87539

mRNA Expression by UniProt/SwissProt for ALDH3B2 Gene

P48448-AL3B2_HUMAN
Tissue specificity: Salivary gland
genes like me logo Genes that share expression patterns with ALDH3B2: view

Protein tissue co-expression partners for ALDH3B2 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for ALDH3B2 Gene

Orthologs for ALDH3B2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ALDH3B2 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Aldh3b2 16
1700055N04Rik 36
  • 63 (a)
OneToMany
Aldh3b2 36
  • 65 (a)
OneToMany
cow
(Bos Taurus)
Mammalia ALDH3B2 36
  • 66 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ALDH3B2 36
  • 55 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 36 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia ALDH3B2 36
  • 96 (a)
OneToOne
chicken
(Gallus gallus)
Aves -- 36
  • 48 (a)
ManyToMany
-- 36
  • 48 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 46 (a)
ManyToMany
-- 36
  • 46 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii -- 35
aldh3b1 36
  • 44 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Aldh-III 37
  • 53 (a)
Aldh-III 36
  • 35 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea alh-4 36
  • 34 (a)
ManyToMany
alh-5 36
  • 35 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HFD1 36
  • 25 (a)
OneToMany
corn
(Zea mays)
Liliopsida Zm.17294 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6683 36
  • 34 (a)
ManyToMany
CSA.9635 36
  • 33 (a)
ManyToMany
Species with no ortholog for ALDH3B2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ALDH3B2 Gene

ENSEMBL:
Gene Tree for ALDH3B2 (if available)
TreeFam:
Gene Tree for ALDH3B2 (if available)

Paralogs for ALDH3B2 Gene

Paralogs for ALDH3B2 Gene

(5) SIMAP similar genes for ALDH3B2 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for ALDH3B2 Gene

genes like me logo Genes that share paralogs with ALDH3B2: view

Variants for ALDH3B2 Gene

Sequence variations from dbSNP and Humsavar for ALDH3B2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs111593447 -- 67,677,224(+) ACCGA(A/T)TTCAA intron-variant
rs111571810 -- 67,682,541(+) GGCTC(A/G)TTCTG upstream-variant-2KB
rs111570903 -- 67,665,145(+) GTGGC(A/G)CCAGA intron-variant
rs111503561 -- 67,664,532(+) GCTCC(A/G)TCTCC reference, missense
rs111332700 -- 67,671,673(+) TCCCG(A/G)GTAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ALDH3B2 Gene

Variant ID Type Subtype PubMed ID
nsv897801 CNV Loss 21882294
esv2422195 CNV Duplication 17116639
dgv1196n71 CNV Loss 21882294
nsv468606 CNV Gain 19166990
dgv154n27 CNV Loss 19166990
dgv1198n71 CNV Loss 21882294
dgv1199n71 CNV Loss 21882294
nsv468609 CNV Loss 19166990
nsv469963 CNV Loss 18288195
nsv897826 CNV Loss 21882294
esv27185 CNV Loss 19812545
esv2744645 CNV Deletion 23290073
esv2179266 CNV Deletion 18987734
esv2744646 CNV Deletion 23290073
esv1206079 CNV Deletion 17803354
dgv161e201 CNV Deletion 23290073
esv2744648 CNV Deletion 23290073
esv2744649 CNV Deletion 23290073
esv2662033 CNV Deletion 23128226

Variation tolerance for ALDH3B2 Gene

Residual Variation Intolerance Score: 99.55% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.59; 78.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ALDH3B2 Gene

HapMap Linkage Disequilibrium report
ALDH3B2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ALDH3B2 Gene

Disorders for ALDH3B2 Gene

Relevant External Links for ALDH3B2

Genetic Association Database (GAD)
ALDH3B2
Human Genome Epidemiology (HuGE) Navigator
ALDH3B2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ALDH3B2
genes like me logo Genes that share disorders with ALDH3B2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ALDH3B2 Gene

Publications for ALDH3B2 Gene

  1. Human aldehyde dehydrogenase genes, ALDH7 and ALDH8: genomic organization and gene structure comparison. (PMID: 9161417) Hsu L.C. … Yoshida A. (Gene 1997) 2 67
  2. Sequencing and expression of the human ALDH8 encoding a new member of the aldehyde dehydrogenase family. (PMID: 8890755) Hsu L.C. … Chang W.-C. (Gene 1996) 2 67
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  4. New genetic associations detected in a host response study to hepatitis B vaccine. (PMID: 20237496) Davila S. … Seielstad M. (Genes Immun. 2010) 67
  5. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PMID: 19343046) Saito A. … Kamatani N. (J. Hum. Genet. 2009) 67

Products for ALDH3B2 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Drug Metabolism: Phase I Enzymes in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate ALDH3B2
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for ALDH3B2
    • Block miRNA regulation of ALDH3B2 using miScript Target Protectors

    Sources for ALDH3B2 Gene

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