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Aliases for ALDH3B1 Gene

Aliases for ALDH3B1 Gene

  • Aldehyde Dehydrogenase 3 Family, Member B1 2 3
  • Aldehyde Dehydrogenase 7 2 3 4
  • ALDH7 3 4 6
  • Aldehyde Dehydrogenase 3B1 2 3
  • EC 1.2.1.5 4 63
  • Aldehyde Dehydrogenase Family 3 Member B1 3
  • EC 1.2.1 63
  • ALDH4 3

External Ids for ALDH3B1 Gene

Previous Symbols for ALDH3B1 Gene

  • ALDH7

Summaries for ALDH3B1 Gene

Entrez Gene Summary for ALDH3B1 Gene

  • This gene encodes a member of the aldehyde dehydrogenase protein family. Aldehyde dehydrogenases are a family of isozymes that may play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. The encoded protein is able to oxidize long-chain fatty aldehydes in vitro, and may play a role in protection from oxidative stress. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

GeneCards Summary for ALDH3B1 Gene

ALDH3B1 (Aldehyde Dehydrogenase 3 Family, Member B1) is a Protein Coding gene. Diseases associated with ALDH3B1 include schizophrenia. Among its related pathways are Metabolism and Chemical carcinogenesis. GO annotations related to this gene include aldehyde dehydrogenase [NAD(P)+] activity and 3-chloroallyl aldehyde dehydrogenase activity. An important paralog of this gene is ALDH3A1.

UniProtKB/Swiss-Prot for ALDH3B1 Gene

  • Oxidizes medium and long chain saturated and unsaturated aldehydes. Metabolizes also benzaldehyde. Low activity towards acetaldehyde and 3,4-dihydroxyphenylacetaldehyde. May not metabolize short chain aldehydes. May use both NADP(+) and NAD(+) as cofactors. May have a protective role against the cytotoxicity induced by lipid peroxidation.

Gene Wiki entry for ALDH3B1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ALDH3B1 Gene

Genomics for ALDH3B1 Gene

Genomic Location for ALDH3B1 Gene

Start:
68,008,578 bp from pter
End:
68,029,282 bp from pter
Size:
20,705 bases
Orientation:
Plus strand

Genomic View for ALDH3B1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ALDH3B1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ALDH3B1 Gene

Regulatory Elements for ALDH3B1 Gene

Proteins for ALDH3B1 Gene

  • Protein details for ALDH3B1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P43353-AL3B1_HUMAN
    Recommended name:
    Aldehyde dehydrogenase family 3 member B1
    Protein Accession:
    P43353
    Secondary Accessions:
    • A3FMP9
    • Q53XL5
    • Q8N515
    • Q96CK8

    Protein attributes for ALDH3B1 Gene

    Size:
    468 amino acids
    Molecular mass:
    51840 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ALDH3B1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ALDH3B1 Gene

Proteomics data for ALDH3B1 Gene at MOPED

Selected DME Specific Peptides for ALDH3B1 Gene

Post-translational modifications for ALDH3B1 Gene

  • Dually lipadated in the C-terminus; prenylation occurs prior, and is a prerequisite for palmitoylation, it is also required for activity towards long-chain substrates.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys41, Lys89, Lys375, and Lys437

Domains for ALDH3B1 Gene

Gene Families for ALDH3B1 Gene

HGNC:
  • ALDH :Aldehyde dehydrogenases

Suggested Antigen Peptide Sequences for ALDH3B1 Gene

Graphical View of Domain Structure for InterPro Entry

P43353

UniProtKB/Swiss-Prot:

AL3B1_HUMAN
Family:
  • Belongs to the aldehyde dehydrogenase family.:
    • P43353
genes like me logo Genes that share domains with ALDH3B1: view

Function for ALDH3B1 Gene

Molecular function for ALDH3B1 Gene

UniProtKB/Swiss-Prot CatalyticActivity: An aldehyde + NAD(P)(+) + H(2)O = a carboxylate + NAD(P)H
UniProtKB/Swiss-Prot Function: Oxidizes medium and long chain saturated and unsaturated aldehydes. Metabolizes also benzaldehyde. Low activity towards acetaldehyde and 3,4-dihydroxyphenylacetaldehyde. May not metabolize short chain aldehydes. May use both NADP(+) and NAD(+) as cofactors. May have a protective role against the cytotoxicity induced by lipid peroxidation.

Enzyme Numbers (IUBMB) for ALDH3B1 Gene

Gene Ontology (GO) - Molecular Function for ALDH3B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003995 acyl-CoA dehydrogenase activity --
GO:0004028 3-chloroallyl aldehyde dehydrogenase activity TAS 7828891
GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity IDA 20699116
GO:0005515 protein binding IPI 25416956
GO:0016491 oxidoreductase activity --
genes like me logo Genes that share ontologies with ALDH3B1: view

Phenotypes for ALDH3B1 Gene

GenomeRNAi human phenotypes for ALDH3B1:
genes like me logo Genes that share phenotypes with ALDH3B1: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ALDH3B1 Gene

Localization for ALDH3B1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ALDH3B1 Gene

Cell membrane; Lipid-anchor. Note=Primarily in the plasma membrane as well as in some punctate structures in the cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ALDH3B1 Gene COMPARTMENTS Subcellular localization image for ALDH3B1 gene
Compartment Confidence
cytosol 3
chloroplast 2
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ALDH3B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 20699116
GO:0005829 cytosol IEA --
GO:0005886 plasma membrane IEA --
GO:0031982 vesicle IDA 19190083
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with ALDH3B1: view

Pathways for ALDH3B1 Gene

genes like me logo Genes that share pathways with ALDH3B1: view

Pathways by source for ALDH3B1 Gene

UniProtKB/Swiss-Prot P43353-AL3B1_HUMAN

  • Pathway: Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2

Gene Ontology (GO) - Biological Process for ALDH3B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006066 alcohol metabolic process TAS 7828891
GO:0006068 ethanol catabolic process IEA --
GO:0006081 cellular aldehyde metabolic process --
GO:0006629 lipid metabolic process TAS 7828891
GO:0008152 metabolic process --
genes like me logo Genes that share ontologies with ALDH3B1: view

Compounds for ALDH3B1 Gene

(20) HMDB Compounds for ALDH3B1 Gene

Compound Synonyms Cas Number PubMed IDs
3,4-Dihydroxybenzeneacetic acid
  • (3,4-Dihydroxyphenyl)acetate
102-32-9
3,4-Dihydroxymandelaldehyde
  • 3,4-Dihydroxyphenylglycolaldehyde
13023-73-9
3,4-Dihydroxyphenylacetaldehyde
  • Protocatechuatealdehyde
5707-55-1
3-Methoxy-4-hydroxyphenylglycolaldehyde
  • a,4-dihydroxy-3-methoxy-Benzeneacetaldehyde
17592-23-3
Acetaldehyde
  • acetaldehyde
75-07-0

(1) Drugbank Compounds for ALDH3B1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
NADH
  • beta-DPNH
606-68-8 target
genes like me logo Genes that share compounds with ALDH3B1: view

Transcripts for ALDH3B1 Gene

Unigene Clusters for ALDH3B1 Gene

Aldehyde dehydrogenase 3 family, member B1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ALDH3B1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b
SP1: - - - -
SP2: -
SP3: - -
SP4:
SP5: - - -
SP6:

Relevant External Links for ALDH3B1 Gene

GeneLoc Exon Structure for
ALDH3B1
ECgene alternative splicing isoforms for
ALDH3B1

Expression for ALDH3B1 Gene

mRNA expression in normal human tissues for ALDH3B1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ALDH3B1 Gene

This gene is overexpressed in Whole Blood (9.2) and Lung (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for ALDH3B1 Gene

SOURCE GeneReport for Unigene cluster for ALDH3B1 Gene Hs.523841

mRNA Expression by UniProt/SwissProt for ALDH3B1 Gene

P43353-AL3B1_HUMAN
Tissue specificity: Highest expression in kidney and lung
genes like me logo Genes that share expressions with ALDH3B1: view

Orthologs for ALDH3B1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ALDH3B1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ALDH3B1 35
  • 86.35 (n)
  • 82.54 (a)
cow
(Bos Taurus)
Mammalia ALDH3B1 35
  • 87.46 (n)
  • 85.47 (a)
ALDH3B1 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ALDH3B1 35
  • 87.54 (n)
  • 87.18 (a)
ALDH3B1 36
  • 52 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Aldh3b1 35
  • 83.4 (n)
  • 83.76 (a)
Aldh3b1 16
Aldh3b1 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 46 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Aldh3b1 35
  • 83.69 (n)
  • 85.26 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 58 (a)
ManyToMany
-- 36
  • 59 (a)
ManyToMany
ALDH3B1 35
  • 71.16 (n)
  • 63.7 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 59 (a)
ManyToMany
-- 36
  • 62 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia aldh3b1 35
  • 64.53 (n)
  • 63.81 (a)
zebrafish
(Danio rerio)
Actinopterygii aldh3b1 35
  • 57.11 (n)
  • 53.88 (a)
aldh3b1 36
  • 52 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005124 35
  • 56.25 (n)
  • 49.45 (a)
fruit fly
(Drosophila melanogaster)
Insecta Aldh-III 35
  • 58.15 (n)
  • 51.54 (a)
Aldh-III 36
  • 41 (a)
OneToMany
Aldh-III 37
  • 50 (a)
worm
(Caenorhabditis elegans)
Secernentea alh-4 36
  • 43 (a)
ManyToMany
alh-5 36
  • 45 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HFD1 35
  • 42.65 (n)
  • 35.23 (a)
HFD1 36
  • 29 (a)
OneToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B12540g 35
  • 42.61 (n)
  • 34.25 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7577 35
rice
(Oryza sativa)
Liliopsida Os.18249 35
wheat
(Triticum aestivum)
Liliopsida Ta.1546 35
bread mold
(Neurospora crassa)
Ascomycetes NCU04013 35
  • 52.38 (n)
  • 40.14 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6683 36
  • 42 (a)
ManyToMany
CSA.9635 36
  • 40 (a)
ManyToMany
Species with no ortholog for ALDH3B1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for ALDH3B1 Gene

ENSEMBL:
Gene Tree for ALDH3B1 (if available)
TreeFam:
Gene Tree for ALDH3B1 (if available)

Paralogs for ALDH3B1 Gene

Paralogs for ALDH3B1 Gene

Selected SIMAP similar genes for ALDH3B1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ALDH3B1: view

Variants for ALDH3B1 Gene

Sequence variations from dbSNP and Humsavar for ALDH3B1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs105147 -- 68,025,546(-) TGTGA(A/G)CACAG intron-variant
rs172620 -- 68,014,099(-) AGCTA(A/G)TGATG intron-variant
rs177812 -- 68,025,382(-) CTGCA(C/G)AAAAA intron-variant
rs191064 -- 68,007,784(-) TCTCA(G/T)CACCT upstream-variant-2KB
rs191065 -- 68,007,710(-) accta(G/T)gttag upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ALDH3B1 Gene

Variant ID Type Subtype PubMed ID
nsv468606 CNV Gain 19166990
dgv394e1 CNV Complex 17122850
dgv395e1 CNV Complex 17122850
nsv428260 CNV Gain 18775914
nsv469856 CNV Gain 16826518
nsv8836 CNV Gain 18304495
dgv1203n71 CNV Loss 21882294
dgv1204n71 CNV Loss 21882294
nsv825963 CNV Gain 20364138
nsv897839 CNV Loss 21882294
dgv156n27 CNV Loss 19166990
dgv1205n71 CNV Loss 21882294
nsv468615 CNV Loss 19166990
nsv469964 CNV Loss 18288195
dgv1206n71 CNV Loss 21882294
dgv1207n71 CNV Loss 21882294
nsv897850 CNV Loss 21882294
nsv897852 CNV Gain 21882294

Relevant External Links for ALDH3B1 Gene

HapMap Linkage Disequilibrium report
ALDH3B1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ALDH3B1 Gene

Disorders for ALDH3B1 Gene

(1) MalaCards Diseases for ALDH3B1 Gene

Search for ALDH3B1 Gene in MalaCards »

Relevant External Links for ALDH3B1

Genetic Association Database (GAD)
ALDH3B1
Human Genome Epidemiology (HuGE) Navigator
ALDH3B1
genes like me logo Genes that share disorders with ALDH3B1: view

No data available for UniProtKB/Swiss-Prot for ALDH3B1 Gene

Publications for ALDH3B1 Gene

  1. Cloning of a cDNA encoding human ALDH7, a new member of the aldehyde dehydrogenase family. (PMID: 7828891) Hsu L.C. … Yoshida A. (Gene 1994) 2 3 4 23
  2. Evidence of epistasis between the catechol-O-methyltransferase and aldehyde dehydrogenase 3B1 genes in paranoid schizophrenia. (PMID: 19159868) Wang Y. … Shen Y. (Biol. Psychiatry 2009) 3 23 48
  3. Human aldehyde dehydrogenase genes, ALDH7 and ALDH8: genomic organization and gene structure comparison. (PMID: 9161417) Hsu L.C. … Yoshida A. (Gene 1997) 2 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for ALDH3B1 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
  • QIAGEN qRT-PCR Assays for microRNAs that regulate ALDH3B1
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for ALDH3B1
    • Block miRNA regulation of ALDH3B1 using miScript Target Protectors

    Sources for ALDH3B1 Gene

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