Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ALDH3B1 Gene

Aliases for ALDH3B1 Gene

  • Aldehyde Dehydrogenase 3 Family Member B1 2 3 5
  • Aldehyde Dehydrogenase 7 2 3 4
  • Aldehyde Dehydrogenase 3B1 2 3
  • EC 1.2.1.5 4 61
  • ALDH7 3 4
  • Aldehyde Dehydrogenase 3 Family, Member B1 2
  • Aldehyde Dehydrogenase Family 3 Member B1 3
  • EC 1.2.1 61
  • ALDH4 3

External Ids for ALDH3B1 Gene

Previous HGNC Symbols for ALDH3B1 Gene

  • ALDH7

Previous GeneCards Identifiers for ALDH3B1 Gene

  • GC11P070300
  • GC11P069474
  • GC11P067553
  • GC11P067534
  • GC11P067776
  • GC11P064111

Summaries for ALDH3B1 Gene

Entrez Gene Summary for ALDH3B1 Gene

  • This gene encodes a member of the aldehyde dehydrogenase protein family. Aldehyde dehydrogenases are a family of isozymes that may play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. The encoded protein is able to oxidize long-chain fatty aldehydes in vitro, and may play a role in protection from oxidative stress. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

GeneCards Summary for ALDH3B1 Gene

ALDH3B1 (Aldehyde Dehydrogenase 3 Family Member B1) is a Protein Coding gene. Among its related pathways are Histidine metabolism and Innate Immune System. GO annotations related to this gene include oxidoreductase activity and 3-chloroallyl aldehyde dehydrogenase activity. An important paralog of this gene is ALDH3B2.

UniProtKB/Swiss-Prot for ALDH3B1 Gene

  • Oxidizes medium and long chain saturated and unsaturated aldehydes. Metabolizes also benzaldehyde. Low activity towards acetaldehyde and 3,4-dihydroxyphenylacetaldehyde. May not metabolize short chain aldehydes. May use both NADP(+) and NAD(+) as cofactors. May have a protective role against the cytotoxicity induced by lipid peroxidation.

Gene Wiki entry for ALDH3B1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ALDH3B1 Gene

Genomics for ALDH3B1 Gene

Regulatory Elements for ALDH3B1 Gene

Enhancers for ALDH3B1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G068016 1.5 Ensembl ENCODE dbSUPER 27 +8.8 8775 2.3 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF48 SP5 NFYC PPARG SMARCB1 ALDH3B1 LOC105369361 ENSG00000255031 GC11M068005
GH11G068008 1.4 ENCODE dbSUPER 24.3 +3.3 3284 7.7 HDGF PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF766 ALDH3B1 LOC105369361 NDUFS8 ENSG00000255031 UNC93B1 FAM86C2P GC11M068005
GH11G068026 1.3 ENCODE dbSUPER 24.7 +21.9 21939 7.6 HDGF PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ALDH3B1 LOC105369361 LOC105369362 NDUFS8 TCIRG1 GC11M068005
GH11G068002 1 ENCODE 8.6 -4.9 -4877 3.1 HDGF PKNOX1 ATF1 FOXA2 CREB3L1 ARID4B SIN3A ZNF48 GTF3C2 GLIS2 ENSG00000260808 RAD9A UNC93B1 NDUFS8 CORO1B ENSG00000255031 ALDH3B1 MRPL21 OR7E1P
GH11G067993 0.7 ENCODE 8.3 -14.5 -14483 0.2 CTCF MAX RAD21 SMC3 ZNF143 ZNF687 ZNF654 L3MBTL2 NR2F1 BHLHE40 ALDH3B1 UNC93B1 OR7E1P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ALDH3B1 on UCSC Golden Path with GeneCards custom track

Promoters for ALDH3B1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000041171 1953 601 HDGF ZFP64 ARID4B SIN3A DMAP1 ZNF48 YY1 GLIS2 ZNF263 SP3

Genomic Location for ALDH3B1 Gene

Chromosome:
11
Start:
68,008,547 bp from pter
End:
68,029,282 bp from pter
Size:
20,736 bases
Orientation:
Plus strand

Genomic View for ALDH3B1 Gene

Genes around ALDH3B1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ALDH3B1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ALDH3B1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ALDH3B1 Gene

Proteins for ALDH3B1 Gene

  • Protein details for ALDH3B1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P43353-AL3B1_HUMAN
    Recommended name:
    Aldehyde dehydrogenase family 3 member B1
    Protein Accession:
    P43353
    Secondary Accessions:
    • A3FMP9
    • Q53XL5
    • Q8N515
    • Q96CK8

    Protein attributes for ALDH3B1 Gene

    Size:
    468 amino acids
    Molecular mass:
    51840 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ALDH3B1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ALDH3B1 Gene

Selected DME Specific Peptides for ALDH3B1 Gene

P43353:
  • NAGQTCV
  • VTLELGG
  • VVLKPSE
  • TLELGGKNPCYVDDNCDPQ
  • TLELGGK
  • IAPWNYP
  • GQTCVAPDY
  • SGMGRYHGKF
  • EKPLALY

Post-translational modifications for ALDH3B1 Gene

  • Dually lipidated in the C-terminus; prenylation occurs prior to, and is a prerequisite for palmitoylation. It is also required for activity towards long-chain substrates.
  • Ubiquitination at Lys41, posLast=8989, posLast=375375, and Lys437
  • Modification sites at PhosphoSitePlus

Domains & Families for ALDH3B1 Gene

Gene Families for ALDH3B1 Gene

Suggested Antigen Peptide Sequences for ALDH3B1 Gene

Graphical View of Domain Structure for InterPro Entry

P43353

UniProtKB/Swiss-Prot:

AL3B1_HUMAN :
  • Belongs to the aldehyde dehydrogenase family.
Family:
  • Belongs to the aldehyde dehydrogenase family.
genes like me logo Genes that share domains with ALDH3B1: view

Function for ALDH3B1 Gene

Molecular function for ALDH3B1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
An aldehyde + NAD(P)(+) + H(2)O = a carboxylate + NAD(P)H.
UniProtKB/Swiss-Prot Function:
Oxidizes medium and long chain saturated and unsaturated aldehydes. Metabolizes also benzaldehyde. Low activity towards acetaldehyde and 3,4-dihydroxyphenylacetaldehyde. May not metabolize short chain aldehydes. May use both NADP(+) and NAD(+) as cofactors. May have a protective role against the cytotoxicity induced by lipid peroxidation.

Enzyme Numbers (IUBMB) for ALDH3B1 Gene

Gene Ontology (GO) - Molecular Function for ALDH3B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004028 3-chloroallyl aldehyde dehydrogenase activity TAS 7828891
GO:0004029 aldehyde dehydrogenase (NAD) activity IEA --
GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity TAS --
GO:0005515 protein binding IPI 25416956
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with ALDH3B1: view
genes like me logo Genes that share phenotypes with ALDH3B1: view

Animal Models for ALDH3B1 Gene

MGI Knock Outs for ALDH3B1:

Animal Model Products

  • Taconic Biosciences Mouse Models for ALDH3B1

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ALDH3B1 Gene

Localization for ALDH3B1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ALDH3B1 Gene

Cell membrane; Lipid-anchor. Note=Primarily in the plasma membrane as well as in some punctate structures in the cytoplasm.

Gene Ontology (GO) - Cellular Components for ALDH3B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 20699116
GO:0005829 cytosol IEA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0030667 secretory granule membrane TAS --
genes like me logo Genes that share ontologies with ALDH3B1: view

No data available for Subcellular locations from COMPARTMENTS for ALDH3B1 Gene

Pathways & Interactions for ALDH3B1 Gene

genes like me logo Genes that share pathways with ALDH3B1: view

UniProtKB/Swiss-Prot P43353-AL3B1_HUMAN

  • Pathway: Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2.

Gene Ontology (GO) - Biological Process for ALDH3B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006066 alcohol metabolic process TAS 7828891
GO:0006068 ethanol catabolic process IEA --
GO:0006081 cellular aldehyde metabolic process IEA --
GO:0006629 lipid metabolic process TAS 7828891
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with ALDH3B1: view

No data available for SIGNOR curated interactions for ALDH3B1 Gene

Drugs & Compounds for ALDH3B1 Gene

(10) Drugs for ALDH3B1 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Chloral hydrate Approved, Illicit, Vet_approved Pharma 16
Phenylacetic acid Approved Pharma 12
Water Approved Pharma 0
acetic acid Approved Nutra Full agonist, Agonist 112
3,4-Dihydroxybenzeneacetic acid Experimental Pharma 0

(20) Additional Compounds for ALDH3B1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
3,4-Dihydroxymandelaldehyde
  • 3,4-Dihydroxyphenylglycolaldehyde
  • 3,4-Dihydroxyphenylglycolic aldehyde
  • a,3,4-Trihydroxy-Benzeneacetaldehyde
  • alpha,3,4-Trihydroxy-Benzeneacetaldehyde
13023-73-9
3,4-Dihydroxymandelic acid
  • 3,4 Dihydroxymandelate
  • 3,4 Dihydroxymandelic acid
  • 3,4-Dihydroxymandelate
  • 3,4-Dihydroxyphenylglycolate
  • 3,4-Dihydroxyphenylglycolic acid
775-01-9
3,4-Dihydroxyphenylacetaldehyde
  • 3,4-Dihydroxy-Benzeneacetaldehyde
  • Protocatechuatealdehyde
5707-55-1
3-Aminopropionaldehyde
  • 3-Aminopropanal
  • 3-Aminopropionaldehyde
  • beta-Aminopropion aldehyde
352-92-1
3-Carbamoyl-2-phenylpropionaldehyde
genes like me logo Genes that share compounds with ALDH3B1: view

Transcripts for ALDH3B1 Gene

Unigene Clusters for ALDH3B1 Gene

Aldehyde dehydrogenase 3 family, member B1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ALDH3B1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b
SP1: - - - -
SP2: -
SP3: - -
SP4:
SP5: - - -
SP6:

Relevant External Links for ALDH3B1 Gene

GeneLoc Exon Structure for
ALDH3B1
ECgene alternative splicing isoforms for
ALDH3B1

Expression for ALDH3B1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ALDH3B1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ALDH3B1 Gene

This gene is overexpressed in Whole Blood (x9.2) and Lung (x4.2).

Protein differential expression in normal tissues from HIPED for ALDH3B1 Gene

This gene is overexpressed in Nasal epithelium (60.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ALDH3B1 Gene



NURSA nuclear receptor signaling pathways regulating expression of ALDH3B1 Gene:

ALDH3B1

SOURCE GeneReport for Unigene cluster for ALDH3B1 Gene:

Hs.523841

mRNA Expression by UniProt/SwissProt for ALDH3B1 Gene:

P43353-AL3B1_HUMAN
Tissue specificity: Highest expression in kidney and lung.
genes like me logo Genes that share expression patterns with ALDH3B1: view

Primer Products

No data available for Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ALDH3B1 Gene

Orthologs for ALDH3B1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ALDH3B1 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia ALDH3B1 34 35
  • 87.54 (n)
cow
(Bos Taurus)
Mammalia ALDH3B1 34 35
  • 87.46 (n)
chimpanzee
(Pan troglodytes)
Mammalia ALDH3B1 34
  • 86.35 (n)
rat
(Rattus norvegicus)
Mammalia Aldh3b1 34
  • 83.69 (n)
mouse
(Mus musculus)
Mammalia Aldh3b1 34 16 35
  • 83.4 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 46 (a)
OneToMany
chicken
(Gallus gallus)
Aves ALDH3B1 34
  • 71.16 (n)
-- 35
  • 59 (a)
ManyToMany
-- 35
  • 58 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 62 (a)
ManyToMany
-- 35
  • 59 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia aldh3b1 34
  • 64.53 (n)
zebrafish
(Danio rerio)
Actinopterygii aldh3b1 34 35
  • 57.11 (n)
fruit fly
(Drosophila melanogaster)
Insecta Aldh-III 36 34 35
  • 58.15 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005124 34
  • 56.25 (n)
worm
(Caenorhabditis elegans)
Secernentea alh-5 35
  • 45 (a)
ManyToMany
alh-4 35
  • 43 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HFD1 34 35
  • 42.65 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B12540g 34
  • 42.61 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7577 34
rice
(Oryza sativa)
Liliopsida Os.18249 34
wheat
(Triticum aestivum)
Liliopsida Ta.1546 34
bread mold
(Neurospora crassa)
Ascomycetes NCU04013 34
  • 52.38 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6683 35
  • 42 (a)
ManyToMany
CSA.9635 35
  • 40 (a)
ManyToMany
Species where no ortholog for ALDH3B1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for ALDH3B1 Gene

ENSEMBL:
Gene Tree for ALDH3B1 (if available)
TreeFam:
Gene Tree for ALDH3B1 (if available)

Paralogs for ALDH3B1 Gene

Paralogs for ALDH3B1 Gene

(4) SIMAP similar genes for ALDH3B1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ALDH3B1: view

Variants for ALDH3B1 Gene

Sequence variations from dbSNP and Humsavar for ALDH3B1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000024444 -- 68,026,585(+) CACCC(C/T)CCAGA intron-variant
rs1000242508 -- 68,028,733(+) GGATT(G/T)AGGGA intron-variant, upstream-variant-2KB, utr-variant-3-prime
rs1000334507 -- 68,014,878(+) GCTGC(A/C)CCGCC intron-variant
rs1000442220 -- 68,009,469(+) CTGGG(A/G)GCATC intron-variant, upstream-variant-2KB
rs1000474865 -- 68,009,745(+) GGTGG(C/T)GCCAA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ALDH3B1 Gene

Variant ID Type Subtype PubMed ID
dgv1221n100 CNV gain 25217958
dgv156n27 CNV loss 19166990
dgv1981n54 CNV gain 21841781
dgv1983n54 CNV loss 21841781
esv2759835 CNV gain+loss 17122850
nsv1038960 CNV loss 25217958
nsv428260 CNV gain 18775914
nsv468606 CNV gain 19166990
nsv468615 CNV loss 19166990
nsv469856 CNV gain 16826518
nsv469964 CNV loss 18288195
nsv475863 CNV novel sequence insertion 20440878
nsv555277 CNV loss 21841781
nsv555278 CNV loss 21841781
nsv825963 CNV gain 20364138
nsv8836 CNV gain 18304495
nsv951026 CNV deletion 24416366
nsv983037 CNV duplication 23825009

Variation tolerance for ALDH3B1 Gene

Gene Damage Index Score: 2.86; 48.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ALDH3B1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ALDH3B1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ALDH3B1 Gene

Disorders for ALDH3B1 Gene

Relevant External Links for ALDH3B1

Genetic Association Database (GAD)
ALDH3B1
Human Genome Epidemiology (HuGE) Navigator
ALDH3B1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ALDH3B1

No disorders were found for ALDH3B1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ALDH3B1 Gene

Publications for ALDH3B1 Gene

  1. Cloning of a cDNA encoding human ALDH7, a new member of the aldehyde dehydrogenase family. (PMID: 7828891) Hsu L.C. … Yoshida A. (Gene 1994) 2 3 4 22 64
  2. Evidence of epistasis between the catechol-O-methyltransferase and aldehyde dehydrogenase 3B1 genes in paranoid schizophrenia. (PMID: 19159868) Wang Y. … Shen Y. (Biol. Psychiatry 2009) 3 22 46 64
  3. Substrate specificity, plasma membrane localization, and lipid modification of the aldehyde dehydrogenase ALDH3B1. (PMID: 23721920) Kitamura T. … Kihara A. (Biochim. Biophys. Acta 2013) 3 4 64
  4. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PMID: 19343046) Saito A. … Kamatani N. (J. Hum. Genet. 2009) 3 46 64
  5. Expression and initial characterization of human ALDH3B1. (PMID: 17382292) Marchitti S.A. … Vasiliou V. (Biochem. Biophys. Res. Commun. 2007) 3 4 64

Products for ALDH3B1 Gene

Sources for ALDH3B1 Gene

Content
Loading form....