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Aliases for ALDH3B1 Gene

Aliases for ALDH3B1 Gene

  • Aldehyde Dehydrogenase 3 Family Member B1 2 3 5
  • Aldehyde Dehydrogenase 7 2 3 4
  • Aldehyde Dehydrogenase 3 Family, Member B1 2 3
  • Aldehyde Dehydrogenase 3B1 2 3
  • EC 1.2.1.5 4 63
  • ALDH7 3 4
  • EC 1.2.1 63
  • ALDH4 3

External Ids for ALDH3B1 Gene

Previous HGNC Symbols for ALDH3B1 Gene

  • ALDH7

Previous GeneCards Identifiers for ALDH3B1 Gene

  • GC11P070300
  • GC11P069474
  • GC11P067553
  • GC11P067534
  • GC11P067776
  • GC11P064111

Summaries for ALDH3B1 Gene

Entrez Gene Summary for ALDH3B1 Gene

  • This gene encodes a member of the aldehyde dehydrogenase protein family. Aldehyde dehydrogenases are a family of isozymes that may play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. The encoded protein is able to oxidize long-chain fatty aldehydes in vitro, and may play a role in protection from oxidative stress. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

GeneCards Summary for ALDH3B1 Gene

ALDH3B1 (Aldehyde Dehydrogenase 3 Family Member B1) is a Protein Coding gene. Among its related pathways are Metabolism and beta-Alanine metabolism (KEGG). GO annotations related to this gene include oxidoreductase activity and 3-chloroallyl aldehyde dehydrogenase activity. An important paralog of this gene is ALDH3A1.

UniProtKB/Swiss-Prot for ALDH3B1 Gene

  • Oxidizes medium and long chain saturated and unsaturated aldehydes. Metabolizes also benzaldehyde. Low activity towards acetaldehyde and 3,4-dihydroxyphenylacetaldehyde. May not metabolize short chain aldehydes. May use both NADP(+) and NAD(+) as cofactors. May have a protective role against the cytotoxicity induced by lipid peroxidation.

Gene Wiki entry for ALDH3B1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ALDH3B1 Gene

Genomics for ALDH3B1 Gene

Regulatory Elements for ALDH3B1 Gene

Genomic Location for ALDH3B1 Gene

Chromosome:
11
Start:
68,008,547 bp from pter
End:
68,029,282 bp from pter
Size:
20,736 bases
Orientation:
Plus strand

Genomic View for ALDH3B1 Gene

Genes around ALDH3B1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ALDH3B1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ALDH3B1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ALDH3B1 Gene

Proteins for ALDH3B1 Gene

  • Protein details for ALDH3B1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P43353-AL3B1_HUMAN
    Recommended name:
    Aldehyde dehydrogenase family 3 member B1
    Protein Accession:
    P43353
    Secondary Accessions:
    • A3FMP9
    • Q53XL5
    • Q8N515
    • Q96CK8

    Protein attributes for ALDH3B1 Gene

    Size:
    468 amino acids
    Molecular mass:
    51840 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ALDH3B1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ALDH3B1 Gene

Proteomics data for ALDH3B1 Gene at MOPED

Selected DME Specific Peptides for ALDH3B1 Gene

Post-translational modifications for ALDH3B1 Gene

  • Dually lipadated in the C-terminus; prenylation occurs prior, and is a prerequisite for palmitoylation, it is also required for activity towards long-chain substrates.
  • Ubiquitination at Lys 41, Lys 89, Lys 375, and Lys 437
  • Modification sites at PhosphoSitePlus

Antibody Products

Domains & Families for ALDH3B1 Gene

Gene Families for ALDH3B1 Gene

Suggested Antigen Peptide Sequences for ALDH3B1 Gene

Graphical View of Domain Structure for InterPro Entry

P43353

UniProtKB/Swiss-Prot:

AL3B1_HUMAN :
  • Belongs to the aldehyde dehydrogenase family.
Family:
  • Belongs to the aldehyde dehydrogenase family.
genes like me logo Genes that share domains with ALDH3B1: view

Function for ALDH3B1 Gene

Molecular function for ALDH3B1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
An aldehyde + NAD(P)(+) + H(2)O = a carboxylate + NAD(P)H.
UniProtKB/Swiss-Prot Function:
Oxidizes medium and long chain saturated and unsaturated aldehydes. Metabolizes also benzaldehyde. Low activity towards acetaldehyde and 3,4-dihydroxyphenylacetaldehyde. May not metabolize short chain aldehydes. May use both NADP(+) and NAD(+) as cofactors. May have a protective role against the cytotoxicity induced by lipid peroxidation.

Enzyme Numbers (IUBMB) for ALDH3B1 Gene

Gene Ontology (GO) - Molecular Function for ALDH3B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity IEA,TAS --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with ALDH3B1: view
genes like me logo Genes that share phenotypes with ALDH3B1: view

Animal Models for ALDH3B1 Gene

MGI Knock Outs for ALDH3B1:

Animal Model Products

  • Taconic Biosciences Mouse Models for ALDH3B1

CRISPR Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ALDH3B1 Gene

Localization for ALDH3B1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ALDH3B1 Gene

Cell membrane; Lipid-anchor. Note=Primarily in the plasma membrane as well as in some punctate structures in the cytoplasm.

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for ALDH3B1 Gene

Pathways & Interactions for ALDH3B1 Gene

genes like me logo Genes that share pathways with ALDH3B1: view

UniProtKB/Swiss-Prot P43353-AL3B1_HUMAN

  • Pathway: Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2.

Gene Ontology (GO) - Biological Process for ALDH3B1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process TAS 7828891
GO:0006665 sphingolipid metabolic process TAS --
GO:0008152 metabolic process IEA --
GO:0030148 sphingolipid biosynthetic process TAS --
GO:0034599 cellular response to oxidative stress IDA 20699116
genes like me logo Genes that share ontologies with ALDH3B1: view

No data available for SIGNOR curated interactions for ALDH3B1 Gene

Drugs & Compounds for ALDH3B1 Gene

(9) Drugs for ALDH3B1 Gene - From: HMDB and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
acetic acid Approved Nutra Full agonist, Agonist 89
3,4-Dihydroxybenzeneacetic acid Experimental Pharma 0
beta-Alanine Experimental Pharma Full agonist, Agonist Endogenous glycine agonist, more selective than taurine (Cat. No. 0209) 0
Chloral hydrate Experimental, Illicit Pharma 14
Phenylacetaldehyde Experimental Pharma 0

(21) Additional Compounds for ALDH3B1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
3,4-Dihydroxymandelaldehyde
  • 3,4-Dihydroxyphenylglycolaldehyde
  • 3,4-Dihydroxyphenylglycolic aldehyde
  • a,3,4-Trihydroxy-Benzeneacetaldehyde
  • alpha,3,4-Trihydroxy-Benzeneacetaldehyde
13023-73-9
3,4-Dihydroxymandelic acid
  • 3,4 Dihydroxymandelate
  • 3,4 Dihydroxymandelic acid
  • 3,4-Dihydroxymandelate
  • 3,4-Dihydroxyphenylglycolate
  • 3,4-Dihydroxyphenylglycolic acid
775-01-9
3,4-Dihydroxyphenylacetaldehyde
  • 3,4-Dihydroxy-Benzeneacetaldehyde
  • Protocatechuatealdehyde
5707-55-1
3-Aminopropionaldehyde
  • 3-Aminopropanal
  • 3-Aminopropionaldehyde
  • beta-Aminopropion aldehyde
352-92-1
3-Carbamoyl-2-phenylpropionaldehyde
genes like me logo Genes that share compounds with ALDH3B1: view

Transcripts for ALDH3B1 Gene

Unigene Clusters for ALDH3B1 Gene

Aldehyde dehydrogenase 3 family, member B1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ALDH3B1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b
SP1: - - - -
SP2: -
SP3: - -
SP4:
SP5: - - -
SP6:

Relevant External Links for ALDH3B1 Gene

GeneLoc Exon Structure for
ALDH3B1
ECgene alternative splicing isoforms for
ALDH3B1

Expression for ALDH3B1 Gene

mRNA expression in normal human tissues for ALDH3B1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ALDH3B1 Gene

This gene is overexpressed in Whole Blood (x9.2) and Lung (x4.2).

Protein differential expression in normal tissues from HIPED for ALDH3B1 Gene

This gene is overexpressed in Nasal epithelium (60.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for ALDH3B1 Gene



SOURCE GeneReport for Unigene cluster for ALDH3B1 Gene Hs.523841

mRNA Expression by UniProt/SwissProt for ALDH3B1 Gene

P43353-AL3B1_HUMAN
Tissue specificity: Highest expression in kidney and lung.
genes like me logo Genes that share expression patterns with ALDH3B1: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for ALDH3B1 Gene

Orthologs for ALDH3B1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ALDH3B1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ALDH3B1 35
  • 86.35 (n)
  • 82.54 (a)
cow
(Bos Taurus)
Mammalia ALDH3B1 36
  • 85 (a)
OneToOne
ALDH3B1 35
  • 87.46 (n)
  • 85.47 (a)
dog
(Canis familiaris)
Mammalia ALDH3B1 35
  • 87.54 (n)
  • 87.18 (a)
ALDH3B1 36
  • 52 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Aldh3b1 16
Aldh3b1 36
  • 83 (a)
OneToOne
Aldh3b1 35
  • 83.4 (n)
  • 83.76 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 46 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Aldh3b1 35
  • 83.69 (n)
  • 85.26 (a)
chicken
(Gallus gallus)
Aves ALDH3B1 35
  • 71.16 (n)
  • 63.7 (a)
-- 36
  • 58 (a)
ManyToMany
-- 36
  • 59 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 59 (a)
ManyToMany
-- 36
  • 62 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia aldh3b1 35
  • 64.53 (n)
  • 63.81 (a)
zebrafish
(Danio rerio)
Actinopterygii aldh3b1 36
  • 52 (a)
OneToMany
aldh3b1 35
  • 57.11 (n)
  • 53.88 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005124 35
  • 56.25 (n)
  • 49.45 (a)
fruit fly
(Drosophila melanogaster)
Insecta Aldh-III 37
  • 50 (a)
Aldh-III 36
  • 41 (a)
OneToMany
Aldh-III 35
  • 58.15 (n)
  • 51.54 (a)
worm
(Caenorhabditis elegans)
Secernentea alh-4 36
  • 43 (a)
ManyToMany
alh-5 36
  • 45 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HFD1 36
  • 29 (a)
OneToMany
HFD1 35
  • 42.65 (n)
  • 35.23 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B12540g 35
  • 42.61 (n)
  • 34.25 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7577 35
rice
(Oryza sativa)
Liliopsida Os.18249 35
wheat
(Triticum aestivum)
Liliopsida Ta.1546 35
bread mold
(Neurospora crassa)
Ascomycetes NCU04013 35
  • 52.38 (n)
  • 40.14 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6683 36
  • 42 (a)
ManyToMany
CSA.9635 36
  • 40 (a)
ManyToMany
Species with no ortholog for ALDH3B1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for ALDH3B1 Gene

ENSEMBL:
Gene Tree for ALDH3B1 (if available)
TreeFam:
Gene Tree for ALDH3B1 (if available)

Paralogs for ALDH3B1 Gene

Paralogs for ALDH3B1 Gene

(4) SIMAP similar genes for ALDH3B1 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ALDH3B1: view

Variants for ALDH3B1 Gene

Sequence variations from dbSNP and Humsavar for ALDH3B1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs308333 -- 68,009,556(-) tttca(C/T)gtgga intron-variant, upstream-variant-2KB
rs308334 -- 68,009,382(-) AGACT(C/G)AGTTT intron-variant, upstream-variant-2KB
rs308335 -- 68,009,216(+) TCTGC(A/G)GAAAG intron-variant, upstream-variant-2KB
rs308336 -- 68,008,850(-) TGTGG(A/G)GGAAG intron-variant, upstream-variant-2KB
rs308337 -- 68,008,822(+) AGGCC(A/C)AGGAA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ALDH3B1 Gene

Variant ID Type Subtype PubMed ID
nsv468606 CNV Gain 19166990
dgv394e1 CNV Complex 17122850
dgv395e1 CNV Complex 17122850
nsv428260 CNV Gain 18775914
nsv469856 CNV Gain 16826518
nsv8836 CNV Gain 18304495
dgv1203n71 CNV Loss 21882294
dgv1204n71 CNV Loss 21882294
nsv825963 CNV Gain 20364138
nsv897839 CNV Loss 21882294
dgv156n27 CNV Loss 19166990
dgv1205n71 CNV Loss 21882294
nsv468615 CNV Loss 19166990
nsv469964 CNV Loss 18288195
dgv1206n71 CNV Loss 21882294
dgv1207n71 CNV Loss 21882294
nsv897850 CNV Loss 21882294
nsv897852 CNV Gain 21882294

Variation tolerance for ALDH3B1 Gene

Gene Damage Index Score: 2.86; 48.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ALDH3B1 Gene

HapMap Linkage Disequilibrium report
ALDH3B1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ALDH3B1 Gene

Disorders for ALDH3B1 Gene

Relevant External Links for ALDH3B1

Genetic Association Database (GAD)
ALDH3B1
Human Genome Epidemiology (HuGE) Navigator
ALDH3B1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ALDH3B1

No disorders were found for ALDH3B1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ALDH3B1 Gene

Publications for ALDH3B1 Gene

  1. Cloning of a cDNA encoding human ALDH7, a new member of the aldehyde dehydrogenase family. (PMID: 7828891) Hsu L.C. … Yoshida A. (Gene 1994) 2 3 4 23 67
  2. Evidence of epistasis between the catechol-O-methyltransferase and aldehyde dehydrogenase 3B1 genes in paranoid schizophrenia. (PMID: 19159868) Wang Y. … Shen Y. (Biol. Psychiatry 2009) 3 23
  3. Human aldehyde dehydrogenase genes, ALDH7 and ALDH8: genomic organization and gene structure comparison. (PMID: 9161417) Hsu L.C. … Yoshida A. (Gene 1997) 2 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for ALDH3B1 Gene

Sources for ALDH3B1 Gene

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