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ALDH3B1 Gene

protein-coding   GIFtS: 60
GCID: GC11P067776

Aldehyde Dehydrogenase 3 Family, Member B1


(Previous symbol: ALDH7)
  See ALDH3B1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Aldehyde Dehydrogenase 3 Family, Member B11 2     EC 1.2.1.53 8
ALDH71 2 3 5     ALDH42
Aldehyde Dehydrogenase 71 2 3     Aldehyde Dehydrogenase Family 3 Member B12
Aldehyde Dehydrogenase 3B11 2     EC 1.2.18

External Ids:    HGNC: 4101   Entrez Gene: 2212   Ensembl: ENSG000000065347   OMIM: 6004665   UniProtKB: P433533   

Export aliases for ALDH3B1 gene to outside databases

Previous GC identifers: GC11P070300 GC11P069474 GC11P068027 GC11P067553 GC11P067534 GC11P064111


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ALDH3B1 Gene:
This gene encodes a member of the aldehyde dehydrogenase protein family. Aldehyde dehydrogenases are a family of
isozymes that may play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid
peroxidation. The encoded protein is able to oxidize long-chain fatty aldehydes in vitro, and may play a role in
protection from oxidative stress. Alternative splicing results in multiple transcript variants. (provided by
RefSeq, Feb 2014)

GeneCards Summary for ALDH3B1 Gene:
ALDH3B1 (aldehyde dehydrogenase 3 family, member B1) is a protein-coding gene. Diseases associated with ALDH3B1 include schizophrenia. GO annotations related to this gene include 3-chloroallyl aldehyde dehydrogenase activity and aldehyde dehydrogenase [NAD(P)+] activity. An important paralog of this gene is ALDH3A1.

UniProtKB/Swiss-Prot: AL3B1_HUMAN, P43353
Function: Oxidizes medium and long chain saturated and unsaturated aldehydes. Metabolizes also benzaldehyde. Low
activity towards acetaldehyde and 3,4-dihydroxyphenylacetaldehyde. May not metabolize short chain aldehydes. May
use both NADP(+) and NAD(+) as cofactors. May have a protective role against the cytotoxicity induced by lipid
peroxidation

Gene Wiki entry for ALDH3B1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_167190.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ALDH3B1 gene promoter:
         AML1a   Pax-5   MIF-1   E47   Egr-2   AREB6   POU2F1   POU2F1a   HOXA5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidALDH3B1 promoter sequence
   Search Chromatin IP Primers for ALDH3B1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ALDH3B1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13   Ensembl cytogenetic band:  11q13.2   HGNC cytogenetic band: 11q13

ALDH3B1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ALDH3B1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P067776:  view genomic region     (about GC identifiers)

Start:
67,776,048 bp from pter      End:
67,796,744 bp from pter
Size:
20,697 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: AL3B1_HUMAN, P43353 (See protein sequence)
Recommended Name: Aldehyde dehydrogenase family 3 member B1 precursor  
Size: 468 amino acids; 51840 Da
Secondary accessions: A3FMP9 Q53XL5 Q8N515 Q96CK8
Alternative splicing: 2 isoforms:  P43353-1   P43353-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ALDH3B1: NX_P43353

Explore proteomics data for ALDH3B1 at MOPED

Post-translational modifications: 

  • Dually lipadated in the C-terminus; prenylation occurs prior, and is a prerequisite for palmitoylation, it is also
    required for activity towards long-chain substrates1
  • Ubiquitination2 at Lys41, Lys89, Lys375, Lys437
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for ALDH3B1 (P43353) (see all 9)
     EKPLALY  TLELGGK  VTLELGG  NAGQTCV 


    See ALDH3B1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_000685.1  NP_001025181.1  NP_001154945.1  NP_001276987.1  NP_001276988.1  

    ENSEMBL proteins: 
     ENSP00000474202   ENSP00000474034   ENSP00000474644   ENSP00000473990  

    ALDH3B1 Human Recombinant Protein Products:

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    antibodies-online peptides for ALDH3B1

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ALDH: Aldehyde dehydrogenases

    Selected InterPro protein domains (see all 6):
     IPR016163 Ald_DH_C
     IPR016162 Ald_DH_N
     IPR012394 Aldehyde_DH_NAD(P)
     IPR016161 Ald_DH/histidinol_DH
     IPR015590 Aldehyde_DH_dom

    Graphical View of Domain Structure for InterPro Entry P43353

    ProtoNet protein and cluster: P43353

    1 Blocks protein domain: IPB002086 Aldehyde dehydrogenase

    UniProtKB/Swiss-Prot: AL3B1_HUMAN, P43353
    Similarity: Belongs to the aldehyde dehydrogenase family


    Find genes that share domains with ALDH3B1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AL3B1_HUMAN, P43353
    Function: Oxidizes medium and long chain saturated and unsaturated aldehydes. Metabolizes also benzaldehyde. Low
    activity towards acetaldehyde and 3,4-dihydroxyphenylacetaldehyde. May not metabolize short chain aldehydes. May
    use both NADP(+) and NAD(+) as cofactors. May have a protective role against the cytotoxicity induced by lipid
    peroxidation
    Catalytic activity: An aldehyde + NAD(P)(+) + H(2)O = a carboxylate + NAD(P)H

         Enzyme Numbers (IUBMB): EC 1.2.1.51 2 EC 1.2.12

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003995acyl-CoA dehydrogenase activity ----
    GO:00040283-chloroallyl aldehyde dehydrogenase activity TAS7828891
    GO:0004030aldehyde dehydrogenase [NAD(P)+] activity IDA--
    GO:0016491oxidoreductase activity ----
         
    Find genes that share ontologies with ALDH3B1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ALDH3B1:
     Upregulation of Wnt/beta-caten 

         1 MGI phenotypic allele for Aldh3b1 (no phenotypes)

    Find genes that share phenotypes with ALDH3B1           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ALDH3B1

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    AL3B1_HUMAN, P43353: Cell membrane; Lipid-anchor. Note=Primarily in the plasma membrane as well as in some
    punctate structures in the cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    chloroplast2
    extracellular1
    mitochondrion1
    nucleus1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol IEA--
    GO:0005886plasma membrane IEA--
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with ALDH3B1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ALDH3B1 About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1Chemical carcinogenesis
    Chemical carcinogenesis0.71
    Drug metabolism - cytochrome P4500.69
    Metabolism of xenobiotics by cytochrome P4500.71
    2Phenylalanine metabolism
    Phenylalanine metabolism0.36
    Tyrosine metabolism0.36
    3Glycolysis and gluconeogenesis short map
    Glycolysis / Gluconeogenesis0.46
    4Metabolism
    Metabolic pathways0.38
    5putrescine degradation III
    putrescine degradation III


    Find genes that share SuperPaths with ALDH3B1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for ALDH3B1
        putrescine degradation III



    Selected Kegg Pathways  (Kegg details for ALDH3B1) (see all 9):
        Glycolysis / Gluconeogenesis
    Histidine metabolism
    Tyrosine metabolism
    Phenylalanine metabolism
    beta-Alanine metabolism

    UniProtKB/Swiss-Prot: AL3B1_HUMAN, P43353
    Pathway: Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ALDH3B1: 

              Amino Acid Metabolism II in human mouse rat
              Drug Metabolism: Phase I Enzymes in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for ALDH3B1

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006066alcohol metabolic process TAS7828891
    GO:0006068ethanol catabolic process IEA--
    GO:0006081cellular aldehyde metabolic process ----
    GO:0006629lipid metabolic process TAS7828891
    GO:0008152metabolic process ----

    Find genes that share ontologies with ALDH3B1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Tocris compounds for ALDH3B1 (AL3B1)

    Selected HMDB Compounds for ALDH3B1 (see all 20)    About this table
    CompoundSynonyms CAS #PubMed Ids
    3,4-Dihydroxybenzeneacetic acid(3,4-Dihydroxyphenyl)acetate (see all 23)102-32-9--
    3,4-Dihydroxymandelaldehyde3,4-Dihydroxyphenylglycolaldehyde (see all 4)13023-73-9--
    3,4-DihydroxyphenylacetaldehydeProtocatechuatealdehyde (see all 2)5707-55-1--
    3-Methoxy-4-hydroxyphenylglycolaldehydea,4-dihydroxy-3-methoxy-Benzeneacetaldehyde (see all 4)17592-23-3--
    Acetaldehydeacetaldehyde (see all 5)75-07-0--
    Acetic acidAcetate (see all 12)64-19-7--
    Ethanol1-Hydroxyethane (see all 57)64-17-5--
    Homovanillic acid(4-Hydroxy-3-methoxyphenyl)acetate (see all 14)306-08-1--
    Homovanillin(4-Hydroxy-3-methoxyphenyl)acetaldehyde (see all 5)5703-24-2--
    Methylimidazole acetaldehyde1-Methylimidazole-4-acetaldehyde (see all 2)19639-03-3--

    1 DrugBank Compound for ALDH3B1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    NADHbeta-DPNH (see all 18)606-68-8target--17139284 17016423



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ALDH3B1 gene (5 alternative transcripts): 
    NM_000694.3  NM_001030010.2  NM_001161473.2  NM_001290058.1  NM_001290059.1  

    Unigene Cluster for ALDH3B1:

    Aldehyde dehydrogenase 3 family, member B1
    Hs.523841  [show with all ESTs]
    Unigene Representative Sequence: NM_001161473
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000433100 ENST00000529232(uc001omy.1 uc001onb.3) ENST00000531459
    ENST00000434449 ENST00000530046 ENST00000525518 ENST00000527179 ENST00000526609
    ENST00000527514 ENST00000316367 ENST00000539229(uc010rpy.2) ENST00000007633(uc001omz.3)
    ENST00000342456(uc001ona.3)
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    Additional mRNA sequence: 

    AK291505.1 BC002553.2 BC013584.2 BC014168.2 BC033099.1 BT009832.1 EF411198.1 U10868.1 
    X75688.1 

    11 DOTS entries:

    DT.86994362  DT.95285234  DT.100778771  DT.100834382  DT.102824711  DT.100031448  DT.101984822  DT.100834381 
    DT.92442872  DT.99969472  DT.95072622 

    Selected AceView cDNA sequences (see all 168):

    BM990586 BU541159 BQ927085 BF725348 T51743 BQ944633 BC033099 BU632191 
    BQ896809 BU552605 AI335963 AA626293 BU542769 AA601588 CA313550 BM991067 
    BQ960848 AI961920 CD678744 BU686212 AI191644 BM561843 BM819950 BQ224935 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ALDH3B1 (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b
    SP1:                                                  -     -     -     -                                 
    SP2:                    -                                                                                 
    SP3:                    -           -                                                                     
    SP4:                                                                                                      
    SP5:        -     -     -                                                                                 


    ECgene alternative splicing isoforms for ALDH3B1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ALDH3B1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGCTCATCC
    ALDH3B1 Expression
    About this image


    ALDH3B1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Lung (Respiratory System)
             Alveolar type II cells
     
     Epithelial Cells
             Mature Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
     
     Ovary (Reproductive System)
             Mature follicles
     
     Eye (Sensory Organs)
             Mature Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
     
     Brain (Nervous System)
             Myelinating Oligodendrocyte Cells Forebrain White Matter
    ALDH3B1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ALDH3B1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.523841

    UniProtKB/Swiss-Prot: AL3B1_HUMAN, P43353
    Tissue specificity: Highest expression in kidney and lung

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ALDH3B1: 
              Amino Acid Metabolism II in human mouse rat
              Drug Metabolism: Phase I Enzymes in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ALDH3B1 gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Aldh3b11 , 5 aldehyde dehydrogenase 3 family, member B11, 5 83.4(n)1
    83.76(a)1
      19 (3.63 cM)5
    676891  NM_026316.21  NP_080592.21 
     39134915 
    chicken
    (Gallus gallus)
    Aves ALDH3B11 aldehyde dehydrogenase 3 family, member B1 71.16(n)
    63.7(a)
      428813  XM_426371.4  XP_426371.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Aldehyde dehydrogenase
    62(a)
    59(a)
    many ↔ many
    many ↔ many
    1(93474583-93478804)
    1(93468360-93510336)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia aldh3b11 aldehyde dehydrogenase 3 family, member B1 64.53(n)
    63.81(a)
      100145787  NM_001127150.1  NP_001120622.1 
    zebrafish
    (Danio rerio)
    Actinopterygii aldh3b11 aldehyde dehydrogenase 3 family, member B1 57.11(n)
    53.88(a)
      282559  NM_173221.2  NP_775328.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Aldh-III1 , 3 aldehyde dehydrogenase3
    Aldehyde dehydrogenase type III1
    50(a)3
    58.15(n)1
    51.54(a)1
      43C53
    453981  NM_165528.31  NP_724562.21 
    worm
    (Caenorhabditis elegans)
    Secernentea alh-56
    alh-46
    Protein ALH-4, isoform a
    45(a)
    43(a)
    many ↔ many
    many ↔ many
    V(1996109-1999581) WBGene00000111
    V(6427211-6429927) WBGene00000110
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HFD11 HFD1 42.65(n)
    35.23(a)
      855137   NP_013828.1 
    Alicante grape
    (Vitis vinifera)
    eudicotyledons Vvi.75772 Vitis vinifera transcribed sequence with weak similarity more 76.5(n)    CF512188.1 
    rice
    (Oryza sativa)
    Liliopsida Os.182492 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 72.04(n)    AF464932.1 


    ENSEMBL Gene Tree for ALDH3B1 (if available)
    TreeFam Gene Tree for ALDH3B1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ALDH3B1 gene
    ALDH3A12  ALDH3A22  ALDH3B22  
    4 SIMAP similar genes for ALDH3B1 using alignment to 4 protein entries:     AL3B1_HUMAN (see all proteins):
    ALDH3B2    DKFZp686E23276    ALDH3A2    ALDH3A1

    Find genes that share paralogs with ALDH3B1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for ALDH3B1 (see all 566)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1875762061,2
    --67695693(+) CACAAC/TATTTT 1 -- us2k10--------
    rs22861721,2
    C,F,H--67695757(-) GGGGAC/TCTCCC 1 -- us2k15Minor allele frequency- T:0.00EA NS 1918
    rs124187741,2
    C,F,H--67695854(+) CTGAGA/GGTTGG 1 -- us2k117Minor allele frequency- G:0.06NS EA NA WA 2340
    rs1154514111,2
    C,F--67696055(+) GTCTGC/TACACA 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs770404721,2
    C,F--67696149(+) CTGGGC/TCCTGG 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1469886371,2
    --67696427(+) TTACAA/GCTGGG 1 -- us2k10--------
    rs1920247511,2
    C--67696457(+) GGGACA/GTTTCT 1 -- us2k10--------
    rs1380771961,2
    C--67696498(+) GTGAGA/CTGCTC 1 -- us2k10--------
    rs1436099681,2
    C--67696505(+) GCTCTC/TGGGCA 1 -- us2k10--------
    rs1432015101,2
    C--67696524(+) GCCCTA/GTGAGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ALDH3B1 (67776048 - 67796744 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ALDH3B1 (see all 18):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv1205n71CNV Loss21882294
    nsv469964CNV Loss18288195
    dgv1206n71CNV Loss21882294
    dgv1203n71CNV Loss21882294
    dgv156n27CNV Loss19166990
    dgv1204n71CNV Loss21882294
    nsv897839CNV Loss21882294
    dgv1207n71CNV Loss21882294
    nsv897850CNV Loss21882294
    nsv468615CNV Loss19166990

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing ALDH3B1
    DNA2.0 Custom Variant and Variant Library Synthesis for ALDH3B1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600466    OMIM disorders: --

    1 disease for ALDH3B1:    
    About MalaCards
    schizophrenia


    Find genes that share disorders with ALDH3B1           About GenesLikeMe

    Genetic Association Database (GAD): ALDH3B1
    Human Genome Epidemiology (HuGE) Navigator: ALDH3B1 (4 documents)

    Export disorders for ALDH3B1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ALDH3B1 gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with ALDH3B1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of a cDNA encoding human ALDH7, a new member of the aldehyde dehydrogenase family. (PubMed id 7828891)1, 2, 3, 9 Hsu L.C.... Yoshida A. (Gene 1994)
    2. Evidence of epistasis between the catechol-O-methyltransferase and aldehyde dehydrogenase 3B1 genes in paranoid schizophrenia. (PubMed id 19159868)1, 4, 9 Wang Y....Shen Y. (Biol. Psychiatry 2009)
    3. Substrate specificity, plasma membrane localization, and lipid modification of the aldehyde dehydrogenase ALDH3B1. (PubMed id 23721920)1, 2 Kitamura T....Kihara A. (Biochim. Biophys. Acta 2013)
    4. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PubMed id 19343046)1, 4 Saito A....Kamatani N. (J. Hum. Genet. 2009)
    5. Expression and initial characterization of human ALDH3B1. (PubMed id 17382292)1, 2 Marchitti S.A.... Vasiliou V. (Biochem. Biophys. Res. Commun. 2007)
    6. Multi-locus association study of schizophrenia susceptibility genes with a posterior probability method. (PubMed id 16092759)1, 4 Sun X....Li Y. (Sci. China, C, Life Sci. 2005)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. Human aldehyde dehydrogenase genes, ALDH7 and ALDH8: genomic organization and gene structure comparison. (PubMed id 9161417)1, 3 Hsu L.C....Yoshida A. (Gene 1997)
    10. Proteomic analysis of the NOS2 interactome in human airway epithelial cells. (PubMed id 23438482)1 Foster M.W....Marshall H.E. (Nitric Oxide 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 221 HGNC: 410 AceView: ALDH3B1 Ensembl:ENSG00000006534 euGenes: HUgn221
    ECgene: ALDH3B1 Kegg: 221 H-InvDB: ALDH3B1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ALDH3B1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for ALDH3B1 gene:
    Search GeneIP for patents involving ALDH3B1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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