Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



ALDH3A2 Gene

protein-coding   GIFtS: 64
GCID: GC17P019551

Aldehyde Dehydrogenase 3 Family, Member A2


(Previous symbols: SLS, ALDH10)
  See ALDH3A2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Aldehyde Dehydrogenase 3 Family, Member A21 2     Aldehyde Dehydrogenase 102 3
ALDH101 2 3 5     Aldehyde Dehydrogenase Family 3 Member A22 3
SLS1 2 5     Microsomal Aldehyde Dehydrogenase2 3
FALDH2 3 5     EC 1.2.1.33 8
Fatty Aldehyde Dehydrogenase1 2     EC 1.2.18

External Ids:    HGNC: 4031   Entrez Gene: 2242   Ensembl: ENSG000000722107   OMIM: 6095235   UniProtKB: P516483   

Export aliases for ALDH3A2 gene to outside databases

Previous GC identifers: GC17P019722 GC17P021188 GC17P019455 GC17P019714 GC17P019492 GC17P018931


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for ALDH3A2 Gene:
Aldehyde dehydrogenase isozymes are thought to play a major role in the detoxification of aldehydes generated by
alcohol metabolism and lipid peroxidation. This gene product catalyzes the oxidation of long-chain aliphatic
aldehydes to fatty acid. Mutations in the gene cause Sjogren-Larsson syndrome. Alternatively spliced transcript
variants encoding different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for ALDH3A2 Gene:
ALDH3A2 (aldehyde dehydrogenase 3 family, member A2) is a protein-coding gene. Diseases associated with ALDH3A2 include sjogren-larsson syndrome, and spastic diplegia. GO annotations related to this gene include long-chain-alcohol oxidase activity and aldehyde dehydrogenase (NAD) activity. An important paralog of this gene is ALDH3A1.

UniProtKB/Swiss-Prot: AL3A2_HUMAN, P51648
Function: Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Active on a variety of
saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length. Responsible for conversion of
the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010718.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the ALDH3A2 gene promoter:
         AP-1   ATF-2   c-Jun   IRF-1   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidALDH3A2 promoter sequence
   Search Chromatin IP Primers for ALDH3A2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ALDH3A2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p11.2   Ensembl cytogenetic band:  17p11.2   HGNC cytogenetic band: 17p11.2

ALDH3A2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ALDH3A2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P019551:  view genomic region     (about GC identifiers)

Start:
19,551,449 bp from pter      End:
19,580,911 bp from pter
Size:
29,463 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: AL3A2_HUMAN, P51648 (See protein sequence)
Recommended Name: Fatty aldehyde dehydrogenase  
Size: 485 amino acids; 54848 Da
Secondary accessions: Q6I9T3 Q93011 Q96J37
Alternative splicing: 2 isoforms:  P51648-1   P51648-2   

Explore the universe of human proteins at neXtProt for ALDH3A2: NX_P51648

Explore proteomics data for ALDH3A2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys266, Lys452
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for ALDH3A2 (P51648) (see all 15)
     EKPLALY  TLELGGK  VTLELGG  GMGAYHG 


    See ALDH3A2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_000373.1  NP_001026976.1  

    ENSEMBL proteins: 
     ENSP00000395845   ENSP00000462964   ENSP00000176643   ENSP00000464153   ENSP00000461916  
     ENSP00000378942   ENSP00000466814   ENSP00000345774   ENSP00000463637   ENSP00000463128  
     ENSP00000458397   ENSP00000458942   ENSP00000464453   ENSP00000459977   ENSP00000462933  
     ENSP00000461235   ENSP00000463924  

    ALDH3A2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for ALDH3A2
    OriGene Protein Over-expression Lysate for ALDH3A2
    OriGene MassSpec for ALDH3A2
    OriGene Custom Protein Services for ALDH3A2
    GenScript Custom Purified and Recombinant Proteins Services for ALDH3A2
    Novus Biologicals ALDH3A2 Proteins
    Novus Biologicals ALDH3A2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ALDH3A2

     
    Search eBioscience for Proteins for ALDH3A2 

    ALDH3A2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for ALDH3A2
    OriGene Custom Antibody Services for ALDH3A2
    Novus Biologicals ALDH3A2 Antibodies
    Abcam antibodies for ALDH3A2
    Cloud-Clone Corp. Antibodies for ALDH3A2
    ThermoFisher Antibodies for ALDH3A2
    LSBio Antibodies in human, mouse, rat for ALDH3A2

    ALDH3A2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ALDH3A2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ALDH3A2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ALDH3A2
    Cloud-Clone Corp. CLIAs for ALDH3A2
    Search eBioscience for ELISAs for ALDH3A2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    ALDH: Aldehyde dehydrogenases

    Selected InterPro protein domains (see all 6):
     IPR016163 Ald_DH_C
     IPR016162 Ald_DH_N
     IPR012394 Aldehyde_DH_NAD(P)
     IPR016161 Ald_DH/histidinol_DH
     IPR015590 Aldehyde_DH_dom

    Graphical View of Domain Structure for InterPro Entry P51648

    ProtoNet protein and cluster: P51648

    UniProtKB/Swiss-Prot: AL3A2_HUMAN, P51648
    Similarity: Belongs to the aldehyde dehydrogenase family


    Find genes that share domains with ALDH3A2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AL3A2_HUMAN, P51648
    Function: Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Active on a variety of
    saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length. Responsible for conversion of
    the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid
    Catalytic activity: An aldehyde + NAD(+) + H(2)O = a carboxylate + NADH

         Enzyme Numbers (IUBMB): EC 1.2.1.31 2 EC 1.2.12

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003995acyl-CoA dehydrogenase activity ----
    GO:0004029aldehyde dehydrogenase (NAD) activity IMP15110319
    GO:0004030aldehyde dehydrogenase [NAD(P)+] activity IEA--
    GO:0016491oxidoreductase activity ----
    GO:0046577long-chain-alcohol oxidase activity IDA18035827
         
    Find genes that share ontologies with ALDH3A2           About GenesLikeMe


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Aldh3a2):
     behavior/neurological  nervous system  vision/eye 

    Find genes that share phenotypes with ALDH3A2           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ALDH3A2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ALDH3A2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ALDH3A2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ALDH3A2

    miRNA
    Products:
        
    miRTarBase miRNAs that target ALDH3A2:
    hsa-mir-193b-3p (MIRT041373), hsa-mir-7-5p (MIRT025933), hsa-mir-155-5p (MIRT020947)

    Block miRNA regulation of human, mouse, rat ALDH3A2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ALDH3A2 (see all 10):
    hsa-miR-3200-5p hsa-miR-4254 hsa-miR-448 hsa-miR-222* hsa-miR-7-2* hsa-miR-4272 hsa-miR-1324 hsa-miR-659
    SwitchGear 3'UTR luciferase reporter plasmidALDH3A2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ALDH3A2
    Predesigned siRNA for gene silencing in human, mouse, rat ALDH3A2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ALDH3A2

    Clone
    Products:
         
    OriGene clones in human, mouse for ALDH3A2 (see all 10)
    OriGene ORF clones in mouse, rat for ALDH3A2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ALDH3A2 (NM_001031806)
    Sino Biological Human cDNA Clone for ALDH3A2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ALDH3A2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALDH3A2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ALDH3A2
    Browse ESI BIO Cell Lines and PureStem Progenitors for ALDH3A2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALDH3A2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    AL3A2_HUMAN, P51648: Endoplasmic reticulum membrane; Single-pass membrane protein; Cytoplasmic side
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    peroxisome5
    cytosol2
    mitochondrion2
    extracellular1
    nucleus1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion ----
    GO:0005743mitochondrial inner membrane IEA--
    GO:0005777peroxisome IDA17510064
    GO:0005783endoplasmic reticulum ----
    GO:0005789endoplasmic reticulum membrane IEA--

    Find genes that share ontologies with ALDH3A2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for ALDH3A2 About   (see all 18)  
    See pathways by source

    SuperPathContained pathways About
    1Tryptophan metabolism
    Tryptophan metabolism0.46
    Tryptophan metabolism0.46
    2beta-Alanine metabolism
    beta-Alanine metabolism
    phenylethylamine degradation I0.00
    3tryptophan utilization II
    tryptophan utilization II0.71
    tryptophan degradation X (mammalian, via tryptamine)0.00
    tryptophan utilization I0.71
    serotonin degradation0.00
    4ethanol degradation II
    ethanol degradation II0.57
    oxidative ethanol degradation III0.57
    ethanol degradation IV0.57
    5Phenylalanine metabolism
    phenylalanine utilization0.33
    phenylalanine degradation IV0.00
    noradrenaline and adrenaline degradation0.31


    Find genes that share SuperPaths with ALDH3A2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    Selected BioSystems Pathways for ALDH3A2 (see all 17)
        dopamine degradation
    oxidative ethanol degradation III
    ethanol degradation II
    ethanol degradation IV
    serotonin degradation



    Selected Kegg Pathways  (Kegg details for ALDH3A2) (see all 14):
        Glycolysis / Gluconeogenesis
    Pentose and glucuronate interconversions
    Ascorbate and aldarate metabolism
    Fatty acid degradation
    Valine, leucine and isoleucine degradation

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ALDH3A2: 
              NFKB Signaling Targets in human mouse rat
              Drug Metabolism: Phase I Enzymes in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for ALDH3A2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ALDH3A2 (P516483 ENSP000003457744) via UniProtKB, MINT, STRING, and/or I2D (see all 75)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GABARAPL1Q9H0R83I2D: score=2 
    MAP1LC3AQ9H4923I2D: score=2 
    MAP3K10Q027793I2D: score=2 
    MAXP612443I2D: score=2 
    MMEP084733I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006081cellular aldehyde metabolic process NAS8528251
    GO:0006714sesquiterpenoid metabolic process IDA18035827
    GO:0007417central nervous system development IMP8528251
    GO:0007422peripheral nervous system development IMP8528251
    GO:0008152metabolic process ----

    Find genes that share ontologies with ALDH3A2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ALDH3A2 (AL3A2)

    Selected HMDB Compounds for ALDH3A2 (see all 34)    About this table
    CompoundSynonyms CAS #PubMed Ids
    (S)-Methylmalonic acid semialdehyde(S)-Methylmalonate semialdehyde (see all 3)99043-16-0--
    2-Propyn-1-al ----
    20-Oxo-leukotriene E420-oxo-LTE(,4) (see all 3)----
    20-oxo-leukotriene B420-carboxyleukotriene B4 ----
    3-Butyn-1-al 52844-23-2--
    3a,7a-Dihydroxy-5b-cholestan-26-al3a,7a-Dihydroxy-5b-cholestan-26-al;3alpha,7alpha-dihydroxy-5beta-cholestan-27-al;5beta-cholestane-3alpha,7alpha-diol-27-al;5beta-cholestan-27-al-3alpha,7alpha-diol ----
    4-Acetamidobutanoic acidN-Acetyl-4-aminobutanoate (see all 11)3025-96-5--
    4-Aminobutyraldehyde4-amino-butanal (see all 5)4390-05-0--
    4-Trimethylammoniobutanal4-Trimethylammoniobutanal (see all 5)64595-66-0--
    4-Trimethylammoniobutanoic acid4-(N-Trimethylamino)butyrate (see all 8)407-64-7--

    1 DrugBank Compound for ALDH3A2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    NADHbeta-DPNH (see all 18)606-68-8target--17139284 17016423 6603890

    Selected Novoseek inferred chemical compound relationships for ALDH3A2 gene (see all 15)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    octadecanal 93.7 4 1939650 (3), 1583866 (1)
    phytenic acid 93.5 2 16435189 (2)
    stearyl alcohol 83.5 2 1583866 (1), 1939650 (1)
    phytanic acid 82.4 9 11306053 (1), 15110319 (1), 11341778 (1), 17510064 (1)
    phytol 78.1 5 15110319 (2), 16435189 (2)
    pristanic acid 71.8 2 9662422 (2)
    propionaldehyde 59.9 1 1939650 (1)
    nad+ 52.6 2 16435189 (1), 19124283 (1)
    leukotriene b4 52.3 8 10774987 (1), 11166796 (1), 11306053 (1), 16996289 (1)
    fatty acid 40.4 16 17302612 (1), 15834613 (1), 17510064 (1), 16996289 (1) (see all 5)



    Find genes that share compounds with ALDH3A2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for ALDH3A2 gene (2 alternative transcripts): 
    NM_000382.2  NM_001031806.1  

    Unigene Cluster for ALDH3A2:

    Aldehyde dehydrogenase 3 family, member A2
    Hs.499886  [show with all ESTs]
    Unigene Representative Sequence: U46689
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 23):
    ENST00000446398 ENST00000467473 ENST00000580550 ENST00000176643(uc002gwb.1)
    ENST00000582991 ENST00000581518 ENST00000395575 ENST00000584332 ENST00000339618(uc002gwa.1)
    ENST00000579855(uc002gwd.1) ENST00000578614 ENST00000472059(uc010cqr.1)
    ENST00000579403 ENST00000476965 ENST00000571537 ENST00000578696 ENST00000574078
    ENST00000571163
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ALDH3A2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ALDH3A2 (see all 10):
    hsa-miR-3200-5p hsa-miR-4254 hsa-miR-448 hsa-miR-222* hsa-miR-7-2* hsa-miR-4272 hsa-miR-1324 hsa-miR-659
    SwitchGear 3'UTR luciferase reporter plasmidALDH3A2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ALDH3A2
    Predesigned siRNA for gene silencing in human, mouse, rat ALDH3A2
    Clone
    Products:
         
    OriGene clones in human, mouse for ALDH3A2 (see all 10)
    OriGene ORF clones in mouse, rat for ALDH3A2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ALDH3A2 (NM_001031806)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ALDH3A2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALDH3A2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ALDH3A2
    OriGene qSTAR qPCR primer pairs in human, mouse for ALDH3A2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ALDH3A2
      QuantiTect SYBR Green Assays in human, mouse, rat ALDH3A2
      QuantiFast Probe-based Assays in human, mouse, rat ALDH3A2

    Additional mRNA sequence: 

    AB208894.1 AK000858.1 AK025677.1 AK123877.1 AK292381.1 AK315096.1 BC002430.2 CR457422.1 
    CR749559.1 L47162.1 U46689.1 

    22 DOTS entries:

    DT.100029567  DT.95297244  DT.95172382  DT.80101547  DT.101981203  DT.100797901  DT.95107048  DT.86849479 
    DT.121006099  DT.100665133  DT.95172383  DT.100797904  DT.100684882  DT.121006144  DT.86855488  DT.100676371 
    DT.95172379  DT.100694705  DT.121006095  DT.121006140  DT.95172381  DT.100830900 

    Selected AceView cDNA sequences (see all 83):

    BP355469 BU542523 AV702571 BI761089 BP349491 BQ942723 BG680118 BM819268 
    BQ639043 CD722389 BM907389 BM834439 BE408899 BQ431853 BU166075 AU280530 
    BI759428 BG256645 BQ878051 BG397046 AW772171 AV653292 AV704668 AV724938 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ALDH3A2 (see all 12)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^
    SP1:                                                                                            -     -                                                         
    SP2:                                                                                            -     -                                                         
    SP3:                                      -                                                     -     -                                                         
    SP4:              -     -     -     -     -                                                                                                                     
    SP5:              -     -     -     -     -     -                                                                                                               

    ExUns: 12a · 12b ^ 13 ^ 14a · 14b ^ 15a · 15b · 15c · 15d
    SP1:              -     -     -                           
    SP2:              -                                       
    SP3:                                                      
    SP4:                                                      
    SP5:                                                      


    ECgene alternative splicing isoforms for ALDH3A2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    ALDH3A2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTCACAACCT
    ALDH3A2 Expression
    About this image


    ALDH3A2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Neural Crest (Gastrulation Derivatives)
             PureStem MEL2, NCr-fac Progenitor
     
     Kidney (Urinary System)
     
     Thyroid (Endocrine System)
     
     Lung (Respiratory System)
     
     Adipose (Muscoskeletal System)
    ALDH3A2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ALDH3A2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.499886
        Pathway & Disease-focused RT2 Profiler PCR Arrays including ALDH3A2: 
              NFKB Signaling Targets in human mouse rat
              Drug Metabolism: Phase I Enzymes in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for ALDH3A2
    OriGene qSTAR qPCR primer pairs in human, mouse for ALDH3A2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ALDH3A2
    QuantiTect SYBR Green Assays in human, mouse, rat ALDH3A2
    QuantiFast Probe-based Assays in human, mouse, rat ALDH3A2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALDH3A2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ALDH3A2 gene from Selected species (see all 19)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Aldh3a21 , 5 aldehyde dehydrogenase family 3, subfamily A21, 5 83.78(n)1
    84.62(a)1
      11 (37.96 cM)5
    116711  NM_007437.41  NP_031463.21 
     612234175 
    chicken
    (Gallus gallus)
    Aves ALDH3A21 aldehyde dehydrogenase 3 family, member A2 68.34(n)
    72.33(a)
      417615  NM_001006223.1  NP_001006223.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Aldehyde dehydrogenase
    62(a)
    1 → many
    GL344046.1(99700-107492)
    African clawed frog
    (Xenopus laevis)
    Amphibia BQ384267.12   -- 75.5(n)    BQ384267.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.55332 Danio rerio aldehyde dehydrogenase mRNA, complete cds 74.08(n)    AF254954.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Aldh-III3 aldehyde dehydrogenase 50(a)   43C5   --
    worm
    (Caenorhabditis elegans)
    Secernentea alh-51 alh-5 53.4(n)
    49.88(a)
      178680  NM_071144.5  NP_503545.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes HFD16
    Putative fatty aldehyde dehydrogenase, located in ...
    30(a)
    1 → many
    XIII(490394-491992) YMR110C
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ALDH3I11 ALDH3I1 50.87(n)
    44.7(a)
      829573  NM_119588.5  NP_567962.1 


    ENSEMBL Gene Tree for ALDH3A2 (if available)
    TreeFam Gene Tree for ALDH3A2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for ALDH3A2 gene
    ALDH3A12  ALDH3B12  ALDH3B22  
    4 SIMAP similar genes for ALDH3A2 using alignment to 13 protein entries:     AL3A2_HUMAN (see all proteins):
    DKFZp686E23276    ALDH3A1    ALDH3B2    ALDH3B1

    Find genes that share paralogs with ALDH3A2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for ALDH3A2 (see all 715)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs725475661,2,,4
    CSjoegren-Larsson syndrome (SLS)4 --19549707(+) TCAGAC/TGCATA 4 R C mis10--------
    rs679391141,2,,4
    C,FSjoegren-Larsson syndrome (SLS)4 --19563816(+) AGTCAA/GAGGTG 4 K E mis14Minor allele frequency- G:0.00MN WA EA 832
    VAR_0175194
    Sjoegren-Larsson syndrome (SLS)4--see VAR_0175192 K N mis40--------
    VAR_0175264
    Sjoegren-Larsson syndrome (SLS)4--see VAR_0175262 F S mis40--------
    VAR_0175214
    Sjoegren-Larsson syndrome (SLS)4--see VAR_0175212 M I mis40--------
    VAR_0022554
    Sjoegren-Larsson syndrome (SLS)4--see VAR_0022552 S L mis40--------
    VAR_0175104
    Sjoegren-Larsson syndrome (SLS)4--see VAR_0175102 I F mis40--------
    VAR_0022544
    Sjoegren-Larsson syndrome (SLS)4--see VAR_0022542 P S mis40--------
    VAR_0175184
    Sjoegren-Larsson syndrome (SLS)4--see VAR_0175182 C Y mis40--------
    VAR_0022494
    Sjoegren-Larsson syndrome (SLS)4--see VAR_0022492 L R mis40--------

    HapMap Linkage Disequilibrium report for ALDH3A2 (19551449 - 19580911 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for ALDH3A2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2659432CNV Deletion23128226
    esv2715735CNV Deletion23290073
    esv4947CNV Deletion18987735
    nsv907865CNV Loss21882294
    nsv428337CNV Loss18775914
    dgv934e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): ALDH3A2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ALDH3A2
    DNA2.0 Custom Variant and Variant Library Synthesis for ALDH3A2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 609523   
    OMIM disorders: 270200  
    UniProtKB/Swiss-Prot: AL3A2_HUMAN, P51648
  • Sjoegren-Larsson syndrome (SLS) [MIM:270200]: An autosomal recessive neurocutaneous disorder
    characterized by a combination of severe mental retardation, spastic di- or tetraplegia and congenital
    ichthyosis. Ichthyosis is usually evident at birth with varying degrees of erythema and scaling, neurologic
    symptoms appear in the first or second year of life. Most patients have an IQ of less than 60. Additional
    clinical features include glistening white spots on the retina, seizures, short stature and speech defects.
    Note=The disease is caused by mutations affecting the gene represented in this entry

  • 4 diseases for ALDH3A2:    
    About MalaCards
    sjogren-larsson syndrome    spastic diplegia    quadriplegia    genital herpes

    3 diseases from the University of Copenhagen DISEASES database for ALDH3A2:
    Quadriplegia     Intellectual disability     Cerebral palsy

    Find genes that share disorders with ALDH3A2           About GenesLikeMe

    8 Novoseek inferred disease relationships for ALDH3A2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sjogren-larsson syndrome 98.9 36 11306053 (2), 11124298 (2), 9829906 (2), 9254849 (1) (see all 25)
    congenital ichthyosis 95.2 7 8884139 (1), 9027499 (1), 16525484 (1), 19197545 (1) (see all 5)
    ichthyosis 93.2 14 11073717 (1), 11306053 (1), 16476818 (1), 10577908 (1) (see all 9)
    phakomatosis 88.7 19 10774987 (1), 11166796 (1), 8884139 (1), 17971613 (1) (see all 9)
    spastic diplegia 88 3 15834613 (1), 19197545 (1)
    mental retardation 81 18 11073717 (1), 11306053 (1), 16476818 (1), 8884139 (1) (see all 11)
    tetraplegias 78.3 4 8884139 (1), 15834613 (1), 19197545 (1)
    genetic disorder 24.6 2 11073717 (1), 9133646 (1)

    Genetic Association Database (GAD): ALDH3A2
    Human Genome Epidemiology (HuGE) Navigator: ALDH3A2 (6 documents)

    Export disorders for ALDH3A2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for ALDH3A2 gene, integrated from 10 sources (see all 104):
    (articles sorted by number of sources associating them with ALDH3A2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The SjAPgren-Larsson syndrome gene is close to D17S805 as determined by linkage analysis and allelic association. (PubMed id 7894487)1, 3, 4 Pigg M....Wadelius C. (Nat. Genet. 1994)
    2. Genomic organization and expression of the human fatty aldehyde dehydrogenase gene (FALDH). (PubMed id 9027499)1, 2, 9 Rogers G.R.... Compton J.G. (Genomics 1997)
    3. The molecular basis of Sjoegren-Larsson syndrome: mutation analysis of the fatty aldehyde dehydrogenase gene. (PubMed id 10577908)1, 2, 9 Rizzo W.B.... Lin Z. (Am. J. Hum. Genet. 1999)
    4. Spectrum of mutations and sequence variants in the FALDH gene in patients with Sjoegren-Larsson syndrome. (PubMed id 9829906)1, 2, 9 Sillen A.... Wadelius C. (Hum. Mutat. 1998)
    5. Human fatty aldehyde dehydrogenase gene (ALDH10): organization and tissue-dependent expression. (PubMed id 9070922)1, 2, 9 Chang C. and Yoshida A. (Genomics 1997)
    6. A missense mutation in the FALDH gene identified in Sjogren-Larsson syndrome patients originating from the northern part of Sweden. (PubMed id 9254849)1, 2, 9 Sillen A.... Wadelius C. (Hum. Genet. 1997)
    7. Sjogren-Larsson syndrome is caused by mutations in the fatty aldehyde dehydrogenase gene. (PubMed id 8528251)1, 2, 9 de Laurenzi V.... Rizzo W.B. (Nat. Genet. 1996)
    8. A novel point mutation of the FALDH gene in a Japanese family with Sjoegren-Larsson syndrome. (PubMed id 10792573)1, 2, 9 Aoki N.... Ito M. (J. Invest. Dermatol. 2000)
    9. The Sjogren-Larsson syndrome gene encodes a hexadecenal dehydrogenase of the sphingosine 1-phosphate degradation pathway. (PubMed id 22633490)1, 2 Nakahara K.... Kihara A. (Mol. Cell 2012)
    10. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 224 HGNC: 403 AceView: ALDH3A2.1 Ensembl:ENSG00000072210 euGenes: HUgn224
    ECgene: ALDH3A2 Kegg: 224 H-InvDB: ALDH3A2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for ALDH3A2 Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=ALDH3A2[genesymbol]

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for ALDH3A2 gene:
    Search GeneIP for patents involving ALDH3A2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for ALDH3A2   OriGene RNAi products in human, mouse, rat for ALDH3A2  
     OriGene qPCR primer pairs and template standards for ALDH3A2   OriGene Protein Over-expression Lysate for ALDH3A2  
     OriGene MassSpec something-or-other for ALDH3A2   OriGene clones in human, mouse for ALDH3A2  
     OriGene qSTAR qPCR primer pairs in human, mouse for ALDH3A2   OriGene Purified Protein for ALDH3A2  
     OriGene ORF clones in mouse, rat for ALDH3A2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ALDH3A2   OriGene Custom Protein Services for ALDH3A2  

     
     
     Block miRNA regulation of human, mouse, rat ALDH3A2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing ALDH3A2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ALDH3A2 Predesigned siRNA for gene silencing in human, mouse, rat ALDH3A2
     QuantiFast Probe-based Assays in human, mouse, rat ALDH3A2 QuantiTect SYBR Green Assays in human, mouse, rat ALDH3A2
     PCR Arrays including human, mouse, rat ALDH3A2 Search Chromatin IP Primers for ALDH3A2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ALDH3A2  Search GeneGlobe Interaction Network for ALDH3A2
     Regulatory tfbs in ALDH3A2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for ALDH3A2 GenScript cDNA clones with any tag delivered in your preferred vector for ALDH3A2
     GenScript Custom Assay Services for ALDH3A2 GenScript Custom overexpressing Cell Line Services for ALDH3A2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for ALDH3A2 (AL3A2)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for ALDH3A2
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     ALDH3A2 antibodies
     ALDH3A2 proteins
     ALDH3A2 lysates
     Antibodies for ALDH3A2
     See all of Abcam's Antibodies, Kits and Proteins for ALDH3A2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for ALDH3A2
     Antibodies for ALDH3A2
     ELISAs for ALDH3A2
     CLIAs for ALDH3A2



     Browse ESI BIO Cell Lines and PureStem Progenitors for ALDH3A2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALDH3A2
     SwitchGear 3'UTR luciferase reporter plasmids for ALDH3A2
     SwitchGear Promoter luciferase reporter plasmids for ALDH3A2
     ThermoFisher Antibodies for ALDH3A2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALDH3A2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ALDH3A2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ALDH3A2
     LSBio Antibodies in human, mouse, rat for ALDH3A2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for ALDH3A2
      Search eBioscience for proteins for ALDH3A2
      Search eBioscience for elisas for ALDH3A2
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ALDH3A2 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4