V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

ALDH3A2 Gene

protein-coding GIFtS: 59

GC17P019492

aldehyde dehydrogenase 3 family, member A2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: SLS, ALDH10)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
ALDH10 ^², ³, ⁵
DKFZp686E23276 ^²
EC 1.2.1.3 ^³
FALDH ^¹, ², ³, ⁵
FLJ20851 ^²
OTTHUMP00000065801 ^²
SLS ^², ⁵

Descriptions
Aldehyde dehydrogenase 10 ^², ³
Aldehyde dehydrogenase family 3 member A2 ^³
Microsomal aldehyde dehydrogenase ^³
aldehyde dehydrogenase 3 family, member A2 ^²
aldehyde dehydrogenase 3A2 ^²
fatty aldehyde dehydrogenase ^²

External Ids
HGNC: 403¹
Entrez Gene: 224²
UniProtKB: P51648³
Ensembl: ENSG00000072210⁷

Search outside databases for aliases for ALDH3A2 gene

Previous GC identifers: GC17P019722 GC17P021188 GC17P019455 GC17P019714

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ALDH3A2:

Aldehyde dehydrogenase isozymes are thought to play a major role in the detoxification of aldehydes

generated by alcohol metabolism and lipid peroxidation. This gene product catalyzes the oxidation

of long-chain aliphatic aldehydes to fatty acid. Mutations in the gene cause Sjogren-Larsson

syndrome. Alternatively spliced transcript variants encoding different isoforms have been found

for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: AL3A2_HUMAN, P51648

Function: Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Active on a

variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ALDH3A2 gene

Entrez Gene cytogenetic band: 17p11.2 Ensembl cytogenetic band: 17p11.2 HGNC cytogenetic band: 17p11.2

ALDH3A2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P019492: (about GC identifiers)

Start:	19,492,641 bp from pter
End:	19,521,501 bp from pter
Size:	28,861 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000017.9 NT_010718.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: AL3A2_HUMAN, P51648 (See protein sequence)

Recommended Name: Fatty aldehyde dehydrogenase

Size: 485 amino acids; 54848 Da

Subcellular location: Endoplasmic reticulum membrane; Single-pass membrane protein; Cytoplasmic

side

Secondary accessions: Q93011 Q96J37

Alternative splicing: 2 isoforms: P51648-1 P51648-2

REFSEQ proteins (2 alternative transcripts):

NP_000373.1 NP_001026976.1

ENSEMBL proteins:

ENSP00000385699 ENSP00000378942 ENSP00000345774 ENSP00000176643

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Aldehyde dehydrogenase 10)
	Human Recombinant Proteins from Abnova (ALDH3A2)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005783	endoplasmic reticulum	IEA	--
GO:0005789	endoplasmic reticulum membrane	IEA	--
GO:0016020	membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

About this table

Antibodies for ALDH3A2:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for ALDH3A2
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Aldehyde dehydrogenase 10), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ALDH3A2)
	Novus Biologicals Antibody for ALDH3A2

Assays for ALDH3A2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P51648

ProtoNet protein and cluster: P51648

UniProtKB/Swiss-Prot: AL3A2_HUMAN, P51648

Similarity: Belongs to the aldehyde dehydrogenase family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ALDH3A2)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001031806

Applied Biosystems Silencer® siRNAs for ALDH3A2

Sigma-Aldrich siRNA and siRNA Panels for ALDH3A2

Sigma-Aldrich shRNA for ALDH3A2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ALDH3A2
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_000382
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_000382
untagged cDNA clones in CMV expression vector (see all 3): NM_000382

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001031806

UniProtKB/Swiss-Prot: AL3A2_HUMAN, P51648

Function: Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Active on a

variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length

Catalytic activity: An aldehyde + NAD(+) + H(2)O = an acid + NADH

Enzyme Number (IUBMB): EC 1.2.1.3

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004028	3-chloroallyl aldehyde dehydrogenase activity	TAS	8528251
GO:0004029	aldehyde dehydrogenase (NAD) activity	IEA	--
GO:0004030	aldehyde dehydrogenase [NAD(P)+] activity	IEA	--
GO:0016491	oxidoreductase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/18 Sigma-Aldrich "Your Favorite Gene" Pathways for ALDH3A2 (Your Favorite Gene powered by Ingenuity) (see all 18 )

Tryptophan Metabolism
Aryl Hydrocarbon Receptor Signaling
Propanoate Metabolism
Xenobiotic Metabolism Signaling
Bile Acid Biosynthesis

GeneDecks ALDH3A2 for the pathways selected above

About GeneDecksing

5/84 Interacting proteins for ALDH3A2 (ENSP00000345774³) via UniProtKB, MINT, and/or STRING (see all 84 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ADHFE1	ENSP00000276576³	STRING (score=.98)
ADH1B	ENSP00000306606³	STRING (score=.942)
ADH1C	ENSP00000209668³	STRING (score=.942)
ADH5	ENSP00000296412³	STRING (score=.931)
ADH4	ENSP00000265512³	STRING (score=.93)

About this table

5/6 Gene Ontology (GO) biological process terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006081	cellular aldehyde metabolic process	IEA	--
GO:0006629	lipid metabolic process	TAS	8528251
GO:0007417	central nervous system development	TAS	8528251
GO:0007422	peripheral nervous system development	TAS	8528251
GO:0008544	epidermis development	TAS	8528251

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ALDH3A2
10/12 Novoseek chemical compound relationships for ALDH3A2 gene (see all 12 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
octadecanal	93.77	4	1939650 (3), 1583866 (1)
phytenic acid	93.54	2	16435189 (2)
phytanic acid	82.79	9	11306053 (1), 15110319 (1), 11341778 (1), 17510064 (1)
phytol	79.03	5	15110319 (2), 16435189 (2)
pristanic acid	72.23	2	9662422 (2)
propionaldehyde	60.70	1	1939650 (1)
nad+	53.60	2	16435189 (1), 19124283 (1)
leukotriene b4	52.82	8	10774987 (1), 11166796 (1), 11306053 (1), 16996289 (1)
fatty acid	41.66	16	17302612 (1), 15834613 (1), 17510064 (1), 16996289 (1) (see all 5)
lipid	32.08	12	18174527 (2), 15931689 (1), 15241804 (1), 15452860 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ALDH3A2)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001031806

Sigma-Aldrich siRNA and siRNA Panels for ALDH3A2

Sigma-Aldrich shRNA for ALDH3A2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000382 NM_001031806

REFSEQ mRNAs for ALDH3A2 gene (2 alternative transcripts):

NM_000382.2 NM_001031806.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000382 NM_001031806

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_000382
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_000382
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_000382

Additional cDNA sequence:

AB208894.1 AK000858.1 AK025677.1 AK123877.1 AK292381.1 AK315096.1 BC002430.2 CR457422.1

CR591336.1 CR749559.1 L47162.1 U46689.1

22 DOTS entries:

DT.100029567 DT.95297244 DT.95172382 DT.101981203 DT.80101547 DT.100797901 DT.95107048 DT.86849479

DT.121006099 DT.100665133 DT.95172383 DT.100797904 DT.100676371 DT.100684882 DT.121006144 DT.86855488

DT.95172379 DT.100694705 DT.121006095 DT.121006140 DT.95172381 DT.100830900

24/83 AceView cDNA sequences (see all 83 ):

BU542523 CD722389 BQ942723 BQ431853 BM819268 BI759428 BP355469 BI761089

AV702571 BQ639043 AU280530 BP349491 BE408899 BM834439 BG680118 BU166075

BM907389 BM834982 AV653292 BG574230 BG035908 AV704609 BI546174 BG031358

highest scoring ESTs for ALDH3A2:

U46689 AA004841 AA005035 AA018851 AA019244 AA019245 AA019525 AA029447 AA029512 AA164606

Unigene Cluster for ALDH3A2:

Aldehyde dehydrogenase 3 family, member A2

Hs.499886 [show with all ESTs]

Unigene Representative Sequence: U46689

GeneLoc Exon Structure

5/12 Alternative Splicing Database (ASD) splice patterns (SP) for ALDH3A2 (see all 12 )

ExUns:	1a	·	1b	^	2a	·	2b	·	2c	·	2d	·	2e	^	3a	·	3b	·	3c	^	4a	·	4b	·	4c	^	5a	·	5b	^	6	^	7a	·	7b	·	7c	·	7d	^	8a	·	8b	^	9	^	10a	·	10b	^	11	^
SP1:																															-		-
SP2:																															-		-
SP3:													-																		-		-
SP4:					-		-		-		-		-
SP5:					-		-		-		-		-		-

ExUns:	12a	·	12b	^	13	^	14a	·	14b	^	15a	·	15b	·	15c	·	15d
SP1:					-		-		-
SP2:					-
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for ALDH3A2

4 Ensembl transcripts including schematic representations:

ENST00000404114 ENST00000395575 ENST00000339618 ENST00000176643

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ALDH3A2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ALDH3A2

¹ / ² / ³

7 probe-sets matching ALDH3A2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
40409_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	U46689	1.00	0.90	0.95	1
202054_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000382	0.60	1.00	0.82	1
202053_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	L47162	0.80	0.88	0.84	1
210544_s_at²^{, 3}	U133-A	2	1.00	0.95	--	--	BC002430	0.80	0.88	0.84	1
202054_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
202053_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
210544_s_at²	U133Plus2	2	1.00	0.95	--	--	--	--	--	--	--

GeneDecks ALDH3A2 for binary patterns associated with the probe-sets selected above

About GeneDecksing

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GTCACAACCT

SOURCE GeneReport for Unigene cluster: Hs.499886
Expression variation in blood from EXPOLDB for ALDH3A2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ALDH3A2 gene from 5/17 species (see all 17 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ALDH3A2¹	--	aldehyde dehydrogenase 3 family, member A2	86.25(n) 88.25(a)	479518 XM_536656.2 XP_536656.2
chimpanzee (Pan troglodytes)	ALDH3A2¹	--	aldehyde dehydrogenase 3 family, member A2	99.04(n) 98.56(a)	454505 XM_511337.2 XP_511337.2
cow (Bos taurus)	ALDH3A2¹	--	aldehyde dehydrogenase 3 family, member A2	83.37(n) 85.57(a)	513967 XM_866959.2 XP_872052.2
rat (Rattus norvegicus)	Aldh3a2¹	--	aldehyde dehydrogenase 3 family, member A2	83.23(n) 85.03(a)	65183 NM_031731.1 NP_113919.1
mouse (Mus musculus)	Aldh3a2^{1, 5}	11 (34.30 cM)⁵	aldehyde dehydrogenase family 3, subfamily A2^{1, 5}	83.78(n)¹ 84.62(a)¹	11671¹ NM_007437.3¹ NP_031463.2¹ AF289804⁵ AF289805⁵ (see all 37)

About this table Species with no ortholog for ALDH3A2

ENSEMBL Gene Tree for ALDH3A2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ALDH3A2 gene

ALDH3A1² ALDH3B1² ALDH3B2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/162 NCBI SNPs in ALDH3A2 are shown (see all 162 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 53)

AB	SNP ID	Valid	Chr 17 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs7216^1,2	A,C,F,H,O	19519465(+)	`CAGGCT/AGAATA`	2	A/A	syn¹ ut3¹		14	NS MN EU EA WA NA	882
	rs3760489^1,2	A,C,F,H	19521601(-)	`GCTACC/TAACCA`	2	--	ng3¹		5	EA EU WA	1890
	rs7215^1,2	A,C,F,H	19521086(+)	`ACTCAG/AAAAGA`	2	--	ut3¹		9	MN EU EA WA NA	956
	rs4621031^1,2	C,F,H	19490862(+)	`ccagaT/Cgaaat`	2	--	ng5¹		8	EU EA WA	834
	rs3888642^1,2	C,F,H	19491818(-)	`tttttA/Ggctca`	2	--	ng5¹		7	EA NA EU WA	464
--	rs16420^1,2	F	19521353(+)	`CTAATAC/-ACATC`	2	--	ut3¹		4	EU NA EA	342
	rs962801^1,2	A,C,F,H,O	19499687(-)	`TTCACG/ATAGCT`	2	--	int¹		17	NS EU EA WA NA	2554
	rs1034897^1,2	A,C,F,H,O	19501444(-)	`TTACAT/CAGCAG`	2	--	int¹		14	EA NA EU WA	962
	rs2072331^1,2	A,C,F,H,O	19516313(-)	`GTTCTT/CGCCTT`	2	--	int¹		10	EA NA EU WA	2060
	rs1004490^1,2	A,C,F,H,O	19496317(+)	`TGCTAA/TTTATG`	2	--	int¹		11	EA EU WA NA	2250

About this table

HapMap Linkage Disequilibrium images for ALDH3A2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 609523 disorders: 270200

UniProtKB/Swiss-Prot: AL3A2_HUMAN, P51648

Defects in ALDH3A2 are the cause of Sjoegren-Larsson syndrome (SLS) [MIM:270200]. SLS is

an autosomal recessive neurocutaneous disorder characterized by a combination of severe mental

retardation, spastic di- or tetraplegia and congenital ichthyosis (increased keratinization).

Ichthyosis is usually evident at birth, neurologic symptoms appear in the first or second year of

life. Most patients have an IQ of less than 60. Additional clinical features include glistening

white spots on the retina, seizures, short stature and speech defects

8 Novoseek disease relationships for ALDH3A2 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
sjogren-larsson syndrome	98.93	36	11306053 (2), 11124298 (2), 9829906 (2), 9254849 (1) (see all 25)
congenital ichthyosis	95.41	7	8884139 (1), 9027499 (1), 16525484 (1), 19197545 (1) (see all 5)
ichthyosis	93.27	14	11073717 (1), 11306053 (1), 16476818 (1), 10577908 (1) (see all 9)
phakomatosis	89.06	19	10774987 (1), 11166796 (1), 8884139 (1), 17971613 (1) (see all 9)
spastic diplegia	88.55	3	15834613 (1), 19197545 (1)
mental retardation	81.17	18	11073717 (1), 11306053 (1), 16476818 (1), 8884139 (1) (see all 11)
tetraplegias	78.91	4	8884139 (1), 15834613 (1), 19197545 (1)
genetic disorder	26.00	2	11073717 (1), 9133646 (1)

About this table

Human Gene Mutation Database: ALDH3A2
Genetic Association Database: ALDH3A2
Human Genome Epidemiology Navigator: ALDH3A2 (2 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/74 PubMed articles for ALDH3A2 gene (see all 74 ):

The Sjogren-Larsson syndrome gene is close to D17S805 as determined by linkage analysis and allelic association. (PubMed id 7894487)^{2, 3, 6} Pigg M....Wadelius C. (1994)
Genomic organization and expression of the human fatty aldehyde dehydrogenase gene (FALDH). (PubMed id 9027499)^{1, 3, 4} Rogers G.R.... Compton J.G. (1997)
The molecular basis of Sjoegren-Larsson syndrome: mutation analysis of the fatty aldehyde dehydrogenase gene. (PubMed id 10577908)^{1, 3, 4} Rizzo W.B.... Lin Z. (1999)
Spectrum of mutations and sequence variants in the FALDH gene in patients with Sjogren-Larsson syndrome. (PubMed id 9829906)^{1, 3, 4} Sillen A.... Wadelius C. (1998)
Human fatty aldehyde dehydrogenase gene (ALDH10): organization and tissue-dependent expression. (PubMed id 9070922)^{1, 3, 4} Chang C. and Yoshida A. (1997)
A missense mutation in the FALDH gene identified in Sjogren-Larsson syndrome patients originating from the northern part of Sweden. (PubMed id 9254849)^{1, 3, 4} Sillen A.... Wadelius C. (1997)
Sjogren-Larsson syndrome is caused by mutations in the fatty aldehyde dehydrogenase gene. (PubMed id 8528251)^{1, 3, 4} de Laurenzi V.... Rizzo W.B. (1996)
A novel point mutation of the FALDH gene in a Japanese family with Sjoegren-Larsson syndrome. (PubMed id 10792573)^{1, 3, 4} Aoki N.... Ito M. (2000)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Sjogren-Larsson syndrome: diversity of mutations and polymorphisms in the fatty aldehyde dehydrogenase gene (ALDH3A2). (PubMed id 15931689)^{1, 3} Rizzo W.B. and Carney G. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 224	HGNC: 403	AceView: ALDH3A2.1	Ensembl:ENSG00000072210	euGenes: HUgn224
ECgene: ALDH3A2	H-InvDB: ALDH3A2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
GeneReviews	http://www.genetests.org/query?gene=ALDH3A2

Licensable Technologies for ALDH3A2
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ALDH3A2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ALDH3A2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ALDH3A2		Antibodies for ALDH3A2
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ALDH3A2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (ALDH3A2)
	Antibodies (ALDH3A2)
	Search for Chimera RNAi
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (Aldehyde dehydrogenase 10)
	Antibodies (Aldehyde dehydrogenase 10)

Search OriGene for ALDH3A2

Search Tocris compounds for ALDH3A2

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for ALDH3A2

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
ALDH3A2 Gene at Home site.
Version 2.41.1
server5.xennexinc.com

ALDH3A2 Gene

protein-coding GIFtS: 59

Aliases &
Descriptions
for ALDH3A2

Summaries
for ALDH3A2

Genomic Location
for ALDH3A2

Proteins
for ALDH3A2

Protein Domains/
Families
for ALDH3A2

Gene Function
for ALDH3A2

Pathways & Interactions
for ALDH3A2

Drugs & Compounds
for ALDH3A2

Transcripts
for ALDH3A2

Expression
for ALDH3A2

Orthologs
for ALDH3A2

Paralogs
for ALDH3A2

SNPs/Variants
for ALDH3A2

Disorders & Mutations
for ALDH3A2

Medical News
for ALDH3A2

Publications
for ALDH3A2

Search for ALDH3A2

Genome Databases showing ALDH3A2

Other Databases showing ALDH3A2

Specialized Databases showing ALDH3A2

Licensable Technologies
for ALDH3A2

Services
for ALDH3A2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ALDH3A2 Gene

protein-coding GIFtS: 59

Aliases & Descriptionsfor ALDH3A2

Summariesfor ALDH3A2

Genomic Locationfor ALDH3A2

Proteinsfor ALDH3A2

Protein Domains/Familiesfor ALDH3A2

Gene Functionfor ALDH3A2

Pathways & Interactionsfor ALDH3A2

Drugs & Compoundsfor ALDH3A2

Transcriptsfor ALDH3A2

Expression for ALDH3A2

Orthologsfor ALDH3A2

Paralogsfor ALDH3A2

SNPs/Variantsfor ALDH3A2

Disorders & Mutationsfor ALDH3A2

Medical Newsfor ALDH3A2

Publicationsfor ALDH3A2

Search for ALDH3A2

Genome Databases showing ALDH3A2

Other Databases showing ALDH3A2

Specialized Databases showing ALDH3A2

Licensable Technologiesfor ALDH3A2

Servicesfor ALDH3A2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ALDH3A2

Summaries
for ALDH3A2

Genomic Location
for ALDH3A2

Proteins
for ALDH3A2

Protein Domains/
Families
for ALDH3A2

Gene Function
for ALDH3A2

Pathways & Interactions
for ALDH3A2

Drugs & Compounds
for ALDH3A2

Transcripts
for ALDH3A2

Expression
for ALDH3A2

Orthologs
for ALDH3A2

Paralogs
for ALDH3A2

SNPs/Variants
for ALDH3A2

Disorders & Mutations
for ALDH3A2

Medical News
for ALDH3A2

Publications
for ALDH3A2

Licensable Technologies
for ALDH3A2

Services
for ALDH3A2