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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ALDH3A1 Gene

protein-coding GIFtS: 68
GCID: GC17M019641

aldehyde dehydrogenase 3 family, member A1

(Previous symbol: ALDH3)

Explore 35 diseases affiliated with
ALDH3A1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Aldehyde Dehydrogenase 3 Family, Member A1¹ ²		Aldehyde Dehydrogenase, Dimeric NADP-Preferring²
ALDH3¹ ² ³ ⁵		Stomach Aldehyde Dehydrogenase²
ALDHIII² ³		Aldehyde Dehydrogenase 3³
EC 1.2.1.5³ ⁸		Aldehyde Dehydrogenase Family 3 Member A1³
Aldehyde Dehydrogenase Isozyme 3²		EC 1.2.1⁸
Aldehyde Dehydrogenase Type III²

External Ids:	HGNC: 405¹	Entrez Gene: 218²	Ensembl: ENSG00000108602⁷	OMIM: 100660⁵	UniProtKB: P30838³

Export aliases for ALDH3A1 gene to outside databases

Previous GC identifers: GC17M019747 GC17M021277 GC17M019545 GC17M019803 GC17M019581 GC17M019020

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ALDH3A1:

Aldehyde dehydrogenases oxidize various aldehydes to the corresponding acids. They are involved in the detoxification

of alcohol-derived acetaldehyde and in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and

lipid peroxidation. The enzyme encoded by this gene forms a cytoplasmic homodimer that preferentially oxidizes

aromatic and medium-chain (6 carbons or more) saturated and unsaturated aldehyde substrates. It is thought to promote

resistance to UV and 4-hydroxy-2-nonenal-induced oxidative damage in the cornea. The gene is located within the

Smith-Magenis syndrome region on chromosome 17. Multiple alternatively spliced variants, encoding the same protein,

have been identified. (provided by RefSeq, Sep 2008)

UniProtKB/Swiss-Prot: AL3A1_HUMAN, P30838

Function: ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the

metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. This protein preferentially

oxidizes aromatic aldehyde substrates. It may play a role in the oxidation of toxic aldehydes

Gene Wiki entry for ALDH3A1 (Aldehyde dehydrogenase 3 family, member A1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000017.10 NC_018928.1 NT_010718.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ALDH3A1 gene promoter:
AML1a
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ALDH3A1 promoter sequence

Search SABiosciences Chromatin IP Primers for ALDH3A1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ALDH3A1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p11.2 Ensembl cytogenetic band: 17p11.2 HGNC cytogenetic band: 17p11.2

ALDH3A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ALDH3A1 gene location

GeneLoc information about chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17M019641: view genomic region (about GC identifiers)

Start:	19,641,297 bp from pter	End:	19,652,256 bp from pter
Size:	10,960 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: AL3A1_HUMAN, P30838 (See protein sequence)

Recommended Name: Aldehyde dehydrogenase, dimeric NADP-preferring

Size: 453 amino acids; 50395 Da

Subunit: Homodimer

Subcellular location: Cytoplasm

2 PDB 3D structures from and Proteopedia for ALDH3A1:

3SZA (3D)

3SZB (3D)

Secondary accessions: A8K828 Q9BT37

Explore the universe of human proteins at neXtProt for ALDH3A1: NX_P30838

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P30838

4/10 DME Specific Peptides for ALDH3A1 (P30838) (see all 10)

EKPLALY

TLELGGK

VTLELGG

VVLKPSE

ALDH3A1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_000682.3 NP_001128639.1 NP_001128640.1

ENSEMBL proteins:

ENSP00000434685 ENSP00000378923 ENSP00000460482 ENSP00000225740 ENSP00000411821

ENSP00000389766 ENSP00000388369 ENSP00000458841 ENSP00000461189 ENSP00000460792

ENSP00000388469

Human Recombinant Protein Products:

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	Novus Biologicals ALDH3A1 Proteins Novus Biologicals ALDH3A1 Lysates
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	ProSpec Recombinant Protein for ALDH3A1
	Uscn Proteins for ALDH3A1

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	--	--
GO:0005783	endoplasmic reticulum	IDA	--
GO:0005829	cytosol	ISS	--

ALDH3A1 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for ALDH3A1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ALDH3A1 for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR016162 Ald_DH_N

IPR012394 Aldehyde_DH_NAD(P)

IPR016163 Ald_DH_C

IPR016161 Ald_DH/histidinol_DH

IPR015590 Aldehyde_DH_dom

Graphical View of Domain Structure for InterPro Entry P30838

ProtoNet protein and cluster: P30838

UniProtKB/Swiss-Prot: AL3A1_HUMAN, P30838

Similarity: Belongs to the aldehyde dehydrogenase family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: AL3A1_HUMAN, P30838

Function: ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the

metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. This protein preferentially

oxidizes aromatic aldehyde substrates. It may play a role in the oxidation of toxic aldehydes

Catalytic activity: An aldehyde + NAD(P)(+) + H(2)O = a carboxylate + NAD(P)H

Biophysicochemical properties: Kinetic parameters: Note=Has a high Km for acetaldehyde;

Enzyme Numbers (IUBMB): EC 1.2.1.5¹ ² EC 1.2.1²

miRNA Products:		OriGene 3'-UTR Clone (see all 3): ALDH3A1 Browse MicroRNA Expression Plasmids
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Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Gene Editing
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALDH3A1

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004028	3-chloroallyl aldehyde dehydrogenase activity	IEA	--
GO:0004029	aldehyde dehydrogenase (NAD) activity	IDA	1737758
GO:0004030	aldehyde dehydrogenase [NAD(P)+] activity	IEA	--
GO:0008106	alcohol dehydrogenase (NADP+) activity	IDA	1737758

ALDH3A1 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for ALDH3A1:

Increased viability after born

Animal Models:
Mouse knock-out Aldh3a1^tm1Jpi for ALDH3A1
1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Aldh3a1):

normal

ALDH3A1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Tyrosine metabolism

	Tyrosine metabolism	1.00			Tyrosine metabolism p.1 (dopamine)	0.28
	Phenylalanine metabolism	0.35			Tyrosine metabolism p.1 (dopamine)	0.28

Drug metabolism - cytochrome P450

Drug metabolism - cytochrome P450

1.00

Metabolism of xenobiotics by cytochrome P450

0.73

beta-Alanine metabolism

beta-Alanine metabolism

1.00

Histidine metabolism

Histidine metabolism

1.00

Ethanol oxidation

Cyclophosphamide Pathway, Pharmacodynamics

0.42

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for ALDH3A1

Tyrosine metabolism p.1 (dopamine)

1 GeneGo (Thomson Reuters) Pathway for ALDH3A1

Tyrosine metabolism p.1 (dopamine)

1 BioSystems Pathway for ALDH3A1

putrescine degradation III

1 PharmGKB Pathway for ALDH3A1

Cyclophosphamide Pathway, Pharmacodynamics

5/8 Kegg Pathways (Kegg details for ALDH3A1) (see all 8):

	Glycolysis / Gluconeogenesis
	Histidine metabolism
	Tyrosine metabolism
	Phenylalanine metabolism
	beta-Alanine metabolism

ALDH3A1 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ALDH3A1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/66 Interacting proteins for ALDH3A1 (P30838³ ENSP00000225740⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 66)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MARCH6	O60337³	I2D: score=3
NAP1L4	Q99733³	I2D: score=3
PRPF40A	O75400³	I2D: score=3
PIGM	Q9H3S5³	I2D: score=2
PTPLB	Q6Y1H2³	I2D: score=2

About this table

Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001666	response to hypoxia	IEA	--
GO:0006081	cellular aldehyde metabolic process	IDA	1737758
GO:0007568	aging	IEA	--
GO:0007584	response to nutrient	IEA	--
GO:0008284	positive regulation of cell proliferation	IEA	--

ALDH3A1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

ALDH3A1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ALDH3A1

10/17 HMDB Compounds for ALDH3A1 (see all 17) About this table

Compound	Synonyms	CAS #	PubMed Ids
3,4-Dihydroxybenzeneacetic acid	(3,4-Dihydroxyphenyl)acetate (see all 23)	102-32-9	--
3,4-Dihydroxymandelaldehyde	3,4-Dihydroxyphenylglycolaldehyde (see all 4)	13023-73-9	--
3,4-Dihydroxymandelic acid	3,4 Dihydroxymandelate (see all 7)	775-01-9	--
3,4-Dihydroxyphenylacetaldehyde	Protocatechuatealdehyde (see all 2)	5707-55-1	--
3-Methoxy-4-hydroxyphenylglycolaldehyde	a,4-dihydroxy-3-methoxy-Benzeneacetaldehyde (see all 4)	17592-23-3	--
Acetaldehyde	acetaldehyde (see all 5)	75-07-0	--
Acetic acid	Acetate (see all 12)	64-19-7	--
Homovanillic acid	(4-Hydroxy-3-methoxyphenyl)acetate (see all 14)	306-08-1	--
Homovanillin	(4-Hydroxy-3-methoxyphenyl)acetaldehyde (see all 5)	5703-24-2	--
Methylimidazole acetaldehyde	1-Methylimidazole-4-acetaldehyde (see all 2)	19639-03-3	--

2 DrugBank Compounds for ALDH3A1 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
NADH	beta-DPNH (see all 18)	606-68-8	target	--	17139284 17016423 16583981
Nicotinamide-Adenine-Dinucleotide	--	53-84-9	target	--	10592235

10/30 Novoseek chemical compound relationships for ALDH3A1 gene (see all 30) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
4-hydroxy-2-oxovalerate	92.1	6	7496535 (2), 10080921 (2), 12764229 (1), 8026764 (1)
acetaldehyde	88.2	61	7496535 (2), 9795248 (2), 8375345 (2), 10080921 (2) (see all 39)
aldophosphamide	87.2	6	8654195 (2), 8124665 (1)
mafosfamide	84	6	8662659 (1), 8124665 (1), 11306049 (1), 9514081 (1) (see all 5)
carboxyphosphamide	80.6	2	8654195 (1)
4-hydroperoxycyclophosphamide	75.2	5	11306049 (2), 16614850 (1), 11749781 (1)
benzaldehyde	73.9	7	15390260 (2), 8662659 (1), 8654195 (1), 8937651 (1)
disulfiram	68.7	5	16462115 (1), 18281128 (1), 20082270 (1), 7907815 (1) (see all 5)
propionaldehyde	63.8	1	12943535 (1)
cyclophosphamide	59.4	24	11914911 (5), 18496131 (3), 9815579 (2), 8662659 (1) (see all 13)

Search CenterWatch for drugs/clinical trials and news about ALDH3A1 / AL3A1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ALDH3A1 gene (3 alternative transcripts):

NM_000691.4 NM_001135167.1 NM_001135168.1

Unigene Cluster for ALDH3A1:

Aldehyde dehydrogenase 3 family, member A1

Hs.531682 [show with all ESTs]

Unigene Representative Sequence: NM_001135168

17 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000468746 ENST00000395555 ENST00000479677(uc002gwk.3) ENST00000494157(uc002gwl.1)

ENST00000225740(uc002gwj.3 uc010cqv.3) ENST00000457500(uc010cqu.3)

ENST00000439102 ENST00000487650 ENST00000485472 ENST00000426645 ENST00000485231

ENST00000575860 ENST00000574162 ENST00000573368 ENST00000570414 ENST00000575103

ENST00000444455(uc010vzd.2)

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Additional cDNA sequence:

AK225505.1 AK225513.1 AK292193.1 AK314584.1 BC004102.2 BC004370.1 BC008892.2 BC021194.2

BT007102.1 M74542.1 M77477.1 S61044.1

16 DOTS entries:

DT.210467 DT.97810270 DT.92448591 DT.100791291 DT.100791293 DT.120934469 DT.95215654 DT.100791286

DT.95215655 DT.120934495 DT.97860716 DT.97860723 DT.100031684 DT.92448589 DT.92448593 DT.97817544

24/377 AceView cDNA sequences (see all 377):

AA315161 BE672958 BM765770 BM695327 BM838769 BM664979 CB104583 CB104617

BE615879 AI652557 BM979497 BM791283 AI206189 BU676804 AW593416 BM771969

AI638819 BM819555 CD014085 BM767910 BU728339 BM836078 BM672965 BM765762

GeneLoc Exon Structure

5/20 Alternative Splicing Database (ASD) splice patterns (SP) for ALDH3A1 (see all 20) About this scheme

ExUns:	1	^	2a	·	2b	·	2c	^	3a	·	3b	^	4a	·	4b	^	5	^	6a	·	6b	·	6c	·	6d	^	7	^	8a	·	8b	·	8c	·	8d	·	8e	^	9a	·	9b	^	10	^	11a	·	11b	·	11c	·	11d	^
SP1:									-		-		-		-		-		-						-		-										-		-
SP2:									-		-		-		-		-		-						-		-										-		-
SP3:									-		-		-		-		-		-						-		-										-		-
SP4:									-		-		-		-		-		-		-		-		-		-										-		-
SP5:									-		-		-		-		-		-		-		-		-		-

ExUns:	12a	·	12b	·	12c	^	13a	·	13b	·	13c	^	14a	·	14b	^	15	^	16	^	17a	·	17b
SP1:	-		-								-
SP2:	-		-								-						-
SP3:	-		-				-		-		-		-
SP4:	-		-								-
SP5:	-		-								-

ECgene alternative splicing isoforms for ALDH3A1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ALDH3A1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGCCCAGGCC

About this image

ALDH3A1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ mesenchymal progenitor MEL2 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ALDH3A1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ALDH3A1

SOURCE GeneReport for Unigene cluster: Hs.531682

UniProtKB/Swiss-Prot: AL3A1_HUMAN, P30838

Tissue specificity: High levels in stomach, esophagus and lung; low level in the liver and kidney

SABiosciences Expression via Pathway-Focused PCR Array including ALDH3A1:

Drug Metabolism: Phase I Enzymes in human mouse rat

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of eukaryotes.

Orthologs for ALDH3A1 gene from 6/26 species (see all 26) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	F1NH33_CHICK⁶	aldehyde dehydrogenase 3 family, member A2	61(a)	1 → many	19(6791277-6797362)
lizard (Anolis carolinensis)	Reptilia	ALDH3A1⁶	--	59(a)	1 → many	GL344046.1(100277-107069)
zebrafish (Danio rerio)	Actinopterygii	aldh16a1⁶ zgc:103715⁶ (see all 4)	zgc:103715 (see all 4)	9(a) 54(a) (see all 4)	possible ortholog many ↔ many (see all 4)	3(32217379-32235491) 21(37864576-37893353)
worm (Caenorhabditis elegans)	Secernentea	alh-5⁶ alh-4⁶	ALdehyde deHydrogenase family member (alh-4)	49(a) 45(a)	many ↔ many many ↔ many	V(1996108-1999580) V(6427194-6429910)
thale cress (Arabidopsis thaliana)	eudicotyledons	ALDH3I1¹	aldehyde dehydrogenase 3I1	47.65(n) 45.68(a)		829573 NM_119588.5 NP_567962.1
rice (Oryza sativa)	Liliopsida	Os.5577²	Oryza sativa (japonica cultivar-group) cDNA clone0 more	72.44(n)		AK068297.1

ENSEMBL Gene Tree for ALDH3A1 (if available)
TreeFam Gene Tree for ALDH3A1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for ALDH3A1 gene

ALDH3A2² ALDH3B2²

5 SIMAP similar genes for ALDH3A1 using alignment to 10 protein entries: AL3A1_HUMAN (see all proteins):

DKFZp686E23276 ALDH3A2 ALDH3B2 ALDH3B1 ALDH2

ALDH3A1 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for ALDH3A1
PGOHUM00000250406

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 17 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs76390606^1,2		--	19019755(+)	`ATCGTC/TTCACA`	3	--	ds500¹		1		NA	120
rs60750445^1,2	C,	--	19019898(+)	`GACCTC/TCCCAA`	3	--	ds500¹		2		WA	120
rs28552545^1,2	C,F,	--	19019926(+)	`GTGTCA/CCCCTG`	3	--	ds500¹		1		WA	118
rs111501205^1,2	F	--	19020231(+)	`GAGCGT/ATTCTC`	3	--	ut3¹		2		CSA	4
rs115563042^1,2	C,F,	--	19020260(+)	`GTGAGG/TGTGGT`	3	--	ut3¹		1		WA	118
rs79434246^1,2	C,	--	19020617(+)	`NNNNAC/TCTTGT`	3	--	int¹		1		NA	120
rs112831562^1,2		--	19020989(+)	`GGGAGG/CCTGCC`	3	--	int¹		1		CSA	2
rs74780319^1,2		--	19021380(+)	`TGACAG/ACAGCC`	3	--	int¹		1		EA	120
rs72841925^1,2	C,	--	19022122(+)	`ACTGGC/GGGCCC`	3	--	int¹		0	--	--	--	--
rs3744693^1,2	C,F,H,	--	19022328(-)	`ACCTCG/CGGATG`	3	--	int¹		4		NS EA	414

HapMap Linkage Disequilibrium report for ALDH3A1 (19641297 - 19652256 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ALDH3A1
1 CNV: 30022
Locus Specific Mutation Databases (LSDB): ALDH3A1

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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ALDH3A1 for disorders           About GeneDecksing

OMIM gene information: 100660    OMIM disorders: --

20/35 diseases for ALDH3A1 (see all 35):    About MalaCards

smith-magenis syndrome acyl-coa dehydrogenase sjogren-larsson syndrome alcoholism

autism spectrum disorder paranoid schizophrenia alcohol dependence mucoepidermoid carcinoma

pterygium alcoholic hepatitis keratoconus hepatocellular carcinoma

breast cancer hepatitis b duodenitis oral cancer

liver disease cataract breast adenocarcinoma adenocarcinoma

7 Novoseek disease relationships for ALDH3A1 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
breast cancer metastatic	26.9	8	11320670 (3), 9815579 (2)
hepatocellular carcinoma	20.8	4	7791543 (2), 1306115 (1)
adenocarcinoma	19.9	6	11306049 (2), 7887982 (1), 9059607 (1), 8068047 (1) (see all 5)
cancer	10.4	5	10469894 (1), 17543846 (1), 18536178 (1), 17590990 (1)
breast cancer	0	4	11914911 (2), 11320670 (1)
tumors	0	31	11320670 (5), 11914911 (4), 10469894 (2), 8654195 (2) (see all 10)
carcinoma	0	1	8124665 (1)

Genetic Association Database (GAD): ALDH3A1
Human Genome Epidemiology (HuGE) Navigator: ALDH3A1 (12 documents)

Export disorders for ALDH3A1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for ALDH3A1 gene, integrated from 9 sources (see all 145):
(articles sorted by number of sources associating them with ALDH3A1)

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Human stomach aldehyde dehydrogenase cDNA and genomic cloning, primary structure, and expression in Escherichia coli. (PubMed id 1737758)^{1, 2, 3, 9} Hsu L.C.... Yoshida A. (1992)
Mutations associated with Sjogren-Larsson syndrome. (PubMed id 9250352)^{1, 2, 9} Tsukamoto N.... Yoshida A. (1997)
Human stomach aldehyde dehydrogenase, ALDH3. (PubMed id 8493892)^{1, 2, 9} Hsu L.C. and Yoshida A. (1993)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Association study of an SNP combination pattern in the dopaminergic pathway in paranoid schizophrenia: a novel strategy for complex disorders. (PubMed id 14745454)^{1, 4} Xu Q....Ju G.Z. (2004)
Assignment of ALDH3 to human chromosome 17p11.2 and ALDH5 to human chromosome 9p13. (PubMed id 7774944)^{1, 3} Hiraoka L.R....Hsieh C.L. (1995)
Structural features of stomach aldehyde dehydrogenase distinguish dimeric aldehyde dehydrogenase as a 'variable' enzyme. 'Variable' and 'constant' enzymes within the alcohol and aldehyde dehydrogenase families. (PubMed id 2037078)^{1, 2} Yin S.-J.... Joernvall H. (1991)
Biochemical, immunological, and molecular characterization of a 'high Km' aldehyde dehydrogenase. (PubMed id 1905102)^{1, 2} Eckey R.... Goedde H.W. (1991)
Human aldehyde dehydrogenase 3A1 (ALDH3A1): biochemical characterization and immunohistochemical localization in the cornea. (PubMed id 12943535)^{1, 9} Pappa A....Vasiliou V. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
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Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 218	HGNC: 405	AceView: ALDH3A1	Ensembl:ENSG00000108602	euGenes: HUgn218
ECgene: ALDH3A1	Kegg: 218	H-InvDB: ALDH3A1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for ALDH3A1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for ALDH3A1	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for ALDH3A1 gene
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Patent Information for ALDH3A1 gene:
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ALDH3A1 Gene

aldehyde dehydrogenase 3 family, member A1

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ALDH3A1 Gene

aldehyde dehydrogenase 3 family, member A1

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