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ALDH2 Gene

protein-coding GIFtS: 74
GCID: GC12P112205

Aldehyde Dehydrogenase 2 Family (Mitochondrial)

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Aliases
Aldehyde Dehydrogenase 2 Family (Mitochondrial)¹ ²		Acetaldehyde Dehydrogenase 2²
ALDH-E2² ³		Aldehyde Dehydrogenase, Mitochondrial²
ALDHI² ³		Liver Mitochondrial ALDH²
ALDM² ³		Nucleus-Encoded Mitochondrial Aldehyde Dehydrogenase 2²
ALDH Class 2² ³		EC 1.2.1⁸
EC 1.2.1.3³ ⁸

External Ids:	HGNC: 404¹	Entrez Gene: 217²	Ensembl: ENSG00000111275⁷	OMIM: 100650⁵	UniProtKB: P05091³

Export aliases for ALDH2 gene to outside databases

Previous GC identifers: GC12P111101 GC12P111726 GC12P111987 GC12P110616 GC12P110667 GC12P109217

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ALDH2 Gene:

This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme

of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase,

cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and

subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Orientals have the

cytosolic isozyme but not the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication

among Orientals than among Caucasians could be related to the absence of a catalytically active form of the

mitochondrial isozyme. The increased exposure to acetaldehyde in individuals with the catalytically inactive form

may also confer greater susceptibility to many types of cancer. This gene encodes a mitochondrial isoform, which

has a low Km for acetaldehydes, and is localized in mitochondrial matrix. Alternative splicing results in

multiple transcript variants encoding distinct isoforms.(provided by RefSeq, Mar 2011)

GeneCards Summary for ALDH2 Gene:

ALDH2 (aldehyde dehydrogenase 2 family (mitochondrial)) is a protein-coding gene. Diseases associated with ALDH2 include sublingual nitroglycerin poor response to, and esophageal cancer, alcohol-related. GO annotations related to this gene include electron carrier activity and aldehyde dehydrogenase [NAD(P)+] activity. An important paralog of this gene is ALDH1L2.

summary for ALDH2 Gene:

Aldehyde dehydrogenase enzymes oxidize aldehydes to generate carboxylic acids for use in the muscle and

heart. Numerous aldehyde dehydrogenase genes exist, of which ALDH2 is best known for its role in alcohol

oxidation. Over 550 aldehyde genes have been identified across different species, which can be split into

numerous families. There are 19 known human aldehyde dehydrogenase genes. ALDH2, a human mitochondrial

enzyme belonging to family 2, is responsible for breaking down acetaldehyde produced by ethanol. Inhibition

of aldehyde dehydrogenase therefore results in the build-up of acetaldehyde, a toxic metabolite which is

thought to be responsible for 'hangover' symptoms.

Gene Wiki entry for ALDH2 Gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:

NC_000012.12 NC_018923.2 NT_029419.13

Regulatory elements:

Regulatory transcription factor binding sites in the ALDH2 gene promoter:
PPAR-alpha PPAR-gamma1 Sp1 p53 FOXJ2 (long isoform) FOXJ2 PPAR-gamma2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ALDH2 promoter sequence

Search Chromatin IP Primers for ALDH2

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ALDH2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.2 Ensembl cytogenetic band: 12q24.12 HGNC cytogenetic band: 12q24.12

ALDH2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ALDH2 gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12P112205: view genomic region (about GC identifiers)

Start:	112,204,691 bp from pter	End:	112,247,789 bp from pter
Size:	43,099 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ALDH2_HUMAN, P05091 (See protein sequence)

Recommended Name: Aldehyde dehydrogenase, mitochondrial precursor

Size: 517 amino acids; 56381 Da

Subunit: Homotetramer

Sequence caution: Sequence=AAA62825.1; Type=Frameshift; Positions=424, 444, 448, 461; Sequence=CAA68290.1;

Type=Frameshift; Positions=Several; Sequence=CAA68290.1; Type=Miscellaneous discrepancy;

Selected PDB 3D structures from and Proteopedia for ALDH2 (see all 24):

1CW3 (3D)

1NZW (3D)

1NZX (3D)

1NZZ (3D)

1O00 (3D)

1O01 (3D)

Secondary accessions: B4DW54 E7EUE5 Q03639 Q6IB13 Q6IV71

Alternative splicing: 2 isoforms: P05091-1 P05091-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ALDH2: NX_P05091

Explore proteomics data for ALDH2 at MOPED

Post-translational modifications:

Modification sites at neXtProt

Modification sites at PhosphoSitePlus

Selected DME Specific Peptides for ALDH2 (P05091) (see all 36)

TLELGGK

WKLGPAL

AGSRTFV

VTLELGG

See ALDH2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts):

NP_000681.2 NP_001191818.1

ENSEMBL proteins:

ENSP00000403349 ENSP00000261733 ENSP00000448179 ENSP00000474669

Reactome Protein details: P05091

ALDH2 Human Recombinant Protein Products:

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	Novus Biologicals ALDH2 Proteins Novus Biologicals ALDH2 Lysates
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	ProSpec Recombinant Protein for ALDH2
	Browse Proteins at Cloud-Clone Corp.

ALDH2 Antibody Products:

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	Abcam antibodies for ALDH2
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	ThermoFisher Antibody for ALDH2
	LSBio Antibodies in human, mouse, rat for ALDH2

ALDH2 Assay Products:

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	Browse ELISAs at Cloud-Clone Corp. Browse CLIAs at Cloud-Clone Corp.

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:

ALDH: Aldehyde dehydrogenases

5 InterPro protein domains:

IPR016163 Ald_DH_C

IPR016162 Ald_DH_N

IPR016161 Ald_DH/histidinol_DH

IPR015590 Aldehyde_DH_dom

IPR016160 Ald_DH_CS

Graphical View of Domain Structure for InterPro Entry P05091

ProtoNet protein and cluster: P05091

2 Blocks protein domains:

IPB001484 Pyrokinin

IPB002086 Aldehyde dehydrogenase

UniProtKB/Swiss-Prot: ALDH2_HUMAN, P05091

Similarity: Belongs to the aldehyde dehydrogenase family

ALDH2 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

UniProtKB/Swiss-Prot Summary: ALDH2_HUMAN, P05091

Catalytic activity: An aldehyde + NAD(+) + H(2)O = a carboxylate + NADH

Genatlas biochemistry entry for ALDH2:

aldehyde dehydrogenase 2,mitochondrial,E2 isoform

Enzyme Numbers (IUBMB): EC 1.2.1.3¹ ² EC 1.2.1²

Gene Ontology (GO): 4 molecular function terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004029	aldehyde dehydrogenase (NAD) activity	EXP	--
GO:0004030	aldehyde dehydrogenase [NAD(P)+] activity	TAS	8903321
GO:0009055	electron carrier activity	TAS	8903321
GO:0016491	oxidoreductase activity	--	--

ALDH2 for ontologies About GeneDecksing

Phenotypes:
15 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Aldh2):

behavior/neurological	cellular	growth/size/body	hematopoietic system	homeostasis/metabolism
immune system	integument	limbs/digits/tail	mortality/aging	nervous system
other	reproductive system	skeleton	tumorigenesis	vision/eye

ALDH2 for phenotypes About GeneDecksing

Animal Models:
MGI mouse knock-out Aldh2^tm1Kaw for ALDH2

inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ALDH2

inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ALDH2

genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ALDH2

genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ALDH2

miRNA Products:		miRTarBase miRNAs that target ALDH2: hsa-mir-615-3p (MIRT039939), hsa-mir-16-5p (MIRT031438), hsa-mir-1 (MIRT023536), hsa-mir-335-5p (MIRT016754)

		Block miRNA regulation of human, mouse, rat ALDH2 using miScript Target Protectors
		Search for qRT-PCR Assays for microRNAs that regulate ALDH2
		SwitchGear 3'UTR luciferase reporter plasmid: ALDH2 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for ALDH2
		Predesigned siRNA for gene silencing in human, mouse, rat ALDH2

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for ALDH2

Clone Products:		OriGene clones in human, mouse for ALDH2 (see all 7) OriGene ORF clones in mouse, rat for ALDH2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): ALDH2 (NM_000690)
		Sino Biological Human cDNA Clone for ALDH2
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ALDH2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALDH2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ALDH2
		Browse ESI BIO Cell Lines and PureStem Progenitors for ALDH2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALDH2

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot

ALDH2_HUMAN, P05091: Mitochondrion matrix

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
mitochondrion	5
cytosol	2
nucleus	1

About this image

Gene Ontology (GO): 2 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005759	mitochondrial matrix	TAS	--
GO:0070062	extracellular vesicular exosome	IDA	19056867

ALDH2 for ontologies About GeneDecksing

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for ALDH2 About (see all 22)

See pathways by source

SuperPath

Contained pathways About

Cytochrome P450 - arranged by substrate type

	Phase 1 - Functionalization of compounds	0.75			Fatty Acid Omega Oxidation	0.00
	Ethanol oxidation	0.00

Tryptophan metabolism

Tryptophan metabolism

0.46

Tryptophan metabolism

0.46

Metabolism

Metabolism

0.38

Metabolic pathways

0.38

beta-Alanine metabolism

beta-Alanine metabolism

phenylethylamine degradation I

0.00

Transmission across Chemical Synapses

	Transmission across Chemical Synapses	0.72			Neurotransmitter Clearance In The Synaptic Cleft	0.00
	Neuronal System	0.68

Pathways by source See SuperPaths
Show all pathways

1 GeneGo (Thomson Reuters) Pathway for ALDH2

Retinol metabolism

Selected BioSystems Pathways for ALDH2 (see all 13)

	oxidative ethanol degradation III
	ethanol degradation II
	ethanol degradation IV
	serotonin degradation
	noradrenaline and adrenaline degradation

2 Reactome Pathways for ALDH2

	Metabolism of serotonin
	Ethanol oxidation

2 PharmGKB Pathways for ALDH2

	Cyclophosphamide Pathway, Pharmacodynamics
	Ifosfamide Pathway, Pharmacodynamics

Selected Kegg Pathways (Kegg details for ALDH2) (see all 14):

	Glycolysis / Gluconeogenesis
	Pentose and glucuronate interconversions
	Ascorbate and aldarate metabolism
	Fatty acid degradation
	Valine, leucine and isoleucine degradation

UniProtKB/Swiss-Prot: ALDH2_HUMAN, P05091

Pathway: Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2

ALDH2 for pathways About GeneDecksing

Pathway & Disease-focused RT² Profiler PCR Arrays including ALDH2:

Fatty Acid Metabolism in human mouse rat

Amino Acid Metabolism II in human mouse rat

Drug Metabolism: Phase I Enzymes in human mouse rat

Stem Cells in human mouse rat

Molecular Toxicology PathwayFinder 384HT in human mouse rat

Interactions:

GeneGlobe Interaction Network for ALDH2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for ALDH2 (P05091^{2, 3} ENSP00000261733⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 331)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
C14orf1	Q9UKR5²^,³	MINT-63389 I2D: score=5
SLC35F6	Q8N357²^,³	MINT-63388 I2D: score=5
UNC119	Q13432²^,³	MINT-63385 I2D: score=5
CRMP1	Q14194²^,³	MINT-63386 I2D: score=4
IGSF21	Q96ID5²^,³	MINT-63387 I2D: score=4

About this table

Gene Ontology (GO): Selected biological process terms (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005975	carbohydrate metabolic process	TAS	8903321
GO:0006066	alcohol metabolic process	TAS	1306115
GO:0006068	ethanol catabolic process	IEA	--
GO:0006069	ethanol oxidation	TAS	--
GO:0006805	xenobiotic metabolic process	TAS	--

ALDH2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse compounds at ApexBio

Compounds for ALDH2 available from Tocris Bioscience About this table

Compound	Action	CAS #
WIN 18446	ALDH1a2 inhibitor	[1477-57-2]
Alda 1	ALDH2 activator; cardioprotective	[349438-38-6]

Selected HMDB Compounds for ALDH2 (see all 43) About this table

Compound	Synonyms	CAS #	PubMed Ids
(S)-Methylmalonic acid semialdehyde	(S)-Methylmalonate semialdehyde (see all 3)	99043-16-0	--
2-Methyl-3-oxopropanoic acid	2-Methyl-3-oxopropanoate (see all 7)	6236-08-4	--
2-Propyn-1-al		--	--
20-Oxo-leukotriene E4	20-oxo-LTE(,4) (see all 3)	--	--
20-oxo-leukotriene B4	20-carboxyleukotriene B4	--	--
3-Aminopropionaldehyde	3-Aminopropanal (see all 3)	352-92-1	--
3-Butyn-1-al		52844-23-2	--
3a,7a-Dihydroxy-5b-cholestan-26-al	3a,7a-Dihydroxy-5b-cholestan-26-al;3alpha,7alpha-dihydroxy-5beta-cholestan-27-al;5beta-cholestane-3alpha,7alpha-diol-27-al;5beta-cholestan-27-al-3alpha,7alpha-diol	--	--
3a,7a-Dihydroxycoprostanic acid	3a,7a-Dihydroxy-5b-cholestan-26-oate (see all 14)	17974-66-2	--
4-Acetamidobutanoic acid	N-Acetyl-4-aminobutanoate (see all 11)	3025-96-5	--

10 DrugBank Compounds for ALDH2 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Daidzin	4',7-Dihydroxyisoflavone (see all 8)	552-66-9	target	--	17139284 17016423 10592235
Nicotinamide-Adenine-Dinucleotide	--	53-84-9	target	--	17139284 17016423 10592235
Crotonaldehyde	--	--	target	--	17139284 17016423
Disulfiram	Disulfuram (see all 16)	97-77-8	target	inhibitor	17220694 16051882
Guanidine	Aminomethanamidine (see all 9)	113-00-8	target	--	17139284 17016423
NADH	beta-DPNH (see all 18)	606-68-8	target	--	17488809 16961761
Amyl Nitrite	Amyl nitrosum (see all 6)	110-46-3	enzyme	substrate	20543077
Benzyl alcohol	(Hydroxymethyl)benzene (see all 10)	100-51-6	enzyme	substrate	7645026
Nitric Oxide	--	10102-43-9	enzyme	inhibitor	16242127
Nitroglycerin	Glyceryl trinitrate (see all 7)	55-63-0	enzyme	substrate	20543077

Selected Novoseek inferred chemical compound relationships for ALDH2 gene (see all 61) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
acetaldehyde	93.7	268	16365683 (5), 18616675 (4), 16403513 (4), 14722101 (4) (see all 99)
daidzin	75.3	28	8433985 (3), 11563931 (3), 9050837 (3), 18613661 (3) (see all 9)
ethanol	75.2	116	19144977 (4), 16316071 (3), 10826103 (3), 8512495 (3) (see all 58)
propionaldehyde	67.3	2	15703303 (1), 17655326 (1)
nitroglycerin	63.4	83	17585900 (5), 16051882 (5), 18272654 (3), 16440063 (3) (see all 21)
retinaldehyde	62	1	10559215 (1)
aldophosphamide	61.2	2	1610409 (2)
rsai	58.1	2	15318112 (1), 11696658 (1)
disulfiram	56.1	8	17980785 (2), 9605433 (2), 9354647 (2), 16051882 (1) (see all 5)
betaine aldehyde	54.7	1	1527093 (1)

ALDH2 for compounds About GeneDecksing

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for ALDH2 gene (2 alternative transcripts):

NM_000690.3 NM_001204889.1

Unigene Cluster for ALDH2:

Aldehyde dehydrogenase 2 family (mitochondrial)

Hs.604551 [show with all ESTs]

Unigene Representative Sequence: NM_000690

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000416293 ENST00000261733(uc001tst.3 uc010syi.2) ENST00000548536

ENST00000549106

miRNA Products:		Block miRNA regulation of human, mouse, rat ALDH2 using miScript Target Protectors
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		Predesigned siRNA for gene silencing in human, mouse, rat ALDH2

Clone Products:		OriGene clones in human, mouse for ALDH2 (see all 7) OriGene ORF clones in mouse, rat for ALDH2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): ALDH2 (NM_000690)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ALDH2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALDH2

Primer Products:		OriGene qPCR primer pairs and template standards for ALDH2 OriGene qSTAR qPCR primer pairs in human, mouse for ALDH2
		Pre-validated RT² qPCR Primer Assay in human, mouse, rat ALDH2
		QuantiTect SYBR Green Assays in human, mouse, rat ALDH2
		QuantiFast Probe-based Assays in human, mouse, rat ALDH2

Additional mRNA sequence:

AK223373.1 AK301375.1 AK314856.1 AY621070.1 BC002967.1 BC071839.1 CR456991.1 K03001.1

M26760.1 M54931.1 S80262.1 X05409.1 Y00109.1

24 DOTS entries:

DT.100825560 DT.219231 DT.100825566 DT.100825563 DT.100030509 DT.100825574 DT.92458180 DT.95159151

DT.100825577 DT.121177828 DT.92458189 DT.95159142 DT.95159145 DT.100825568 DT.121177818 DT.121177839

DT.92458178 DT.95159116 DT.100825562 DT.121177767 DT.121177793 DT.95159148 DT.92018440 DT.92458173

651 AceView cDNA sequences (see top 24):

BC015056 BG696274 AI056873 AI460073 AA969786 AW188884 AV650553 AI186384

AA419072 T08954 AA243179 BI834562 BQ631709 BP871792 CA424936 BG056829

BM765982 CR617194 AI632521 BM784372 BM664828 BU151478 BU849300 BQ362166

AW020236 AV647139 BQ881103 AI261830 BM765605 AI865937 AA995393 BU626457

BX488932 BM760986 AI160133 BM853466 CD014082 AI272886 CN479669 BU171977

AL522212 BM702187 AI751738 AI870910 CB851098 BI771112 BM982203 AA350809

AI276955 AA973381 BU607893 CD368410 CR609508 AI354279 AA316218 AA830815

AW102979 AW105496 AL043850 AV653398 BM740979 AA677335 AI632626 NM_025247

AI499010 CD515435 BC003698 AL531568 BI491284 BM746224 BE502351 CF456426

AA862149 BQ925300 BM765615 BM993788 BM784026 AV651965 BM772876 CR591627

AA548678 BQ347284 AA715095 BM765860 AA826948 BM702136 AI564125 AL564795

CR620819 CA397701 BP430017 AV650270 F37029 K03001 AI568300 AI090447

AY323912 BX089391 AW300041 AL522848 AA341219 BQ071238 BU186773 AI017596

BM695868 AL043849 CN478497 AL538754 R53433 BM986820 BM784297 BF725614

BX420523 AY621070 T72070 AL532964 AI350206 BQ648251 BU732519 CB997156

BM852361 NM_000690 AV647132 BQ933288 AA332335 BM782514 CD721913 AV655407

AK097425 BM511646 BM980181 BE463837 AA350808 BI517895 BX448088 BM992703

BM773382 BM739192 AA649842 BC071839 BM919125 BQ013909 AL548084 BU174018

M26760 W17229 BM766085 AI146792 BM783506 BE272838 AA923050 BE887478

CB991970 BG743241 BQ651870 BQ648302 AV650275 BU687348 AW473980 BQ083488

CR618953 BP430561 CN484903 BQ643713 BU552540 AL529224 BF808561 BG564228

CB851683 AV655305 AA687978 AI627757 AW768305 BF311303 N74351 BU156710

CD609389 W90656 AA806909 AA857126 AA936763 AA830692 T28511 BE396883

AW295020 CR456991 CB269884 BQ648143 AA828220 BQ879981 AI950247 R07565

BG428456 BX453759 BI599786 AW851241 BX957030 W67184 AI942236 AV657228

AA076429 AW270045 AA351250 CB162312 BM754970 AV693735 BG705866 BM562957

BG703709 AI338644 AI884933 AV706424 AI184077 BQ362168 CD609387 CD250420

AI766057 BE259405 BE512931 AI052517 AW452861 BI668144 AI857571 CB161783

AA017217 BG105703 CF272524 AW081518 BQ315616 BU177658 BQ339093 AA628643

BG744459 F25106 AV721915 AL532910 BQ678707 BM853139 BU617708 BX383653

CB241032 AL534034 AW514959 AA701647 AA360052 BQ653982 BE268288 AA489164

AV659530 BC002967 BM694407 AV723394 BI598385 BI818497 AL553428 BQ708964

AI366145 N35960 AW149663 BM741106 BQ646098 BE269992 AA334335 CB269953

AV662302 BX448087 H81440 CB163633 AA789204 BG721446 BF793170 C04917

AI745184 BQ649410 AI984337 CD609386 BG745105 CB991534 AW089862 AV659144

AA548866 BM817637 BQ632009 AL576537 AL540170 BC054886 BI597143 AV690920

AI862132 AW021522 AL545580 AL545610 AI348381 AA305818 AI889135 BE562170

CB267416 AA419133 BG740760 AV701585 AI346161 D25565 CD609388 CB268218

AW295074 BG706187 AI183979 AK092356 BG696292 AW851378 CB144887 BQ433381

BU732011 AA191502 BM826605 AA565719 BI914151 BG386210 BG341751 BP346797

AI339715 AA765002 AW002529 BM769438 AA322407 BQ002641 BI226360 BX473078

BU689240 BI668048 BQ643884 AA700657 CF994941 N27870 CB990195 AI379712

BM708164 AL564722 BI259438 AV703977 BE048742 BI667488 BM991609 AI245370

BM760214 CA444245 BM817955 AI279282 AI190867 AA581431 BI463093 BP347555

CB955700 BF313441 AI268380 AW589506 BI599195 AI992012 CA419108 BG332061

BM851430 BQ694149 CD368353 AV653686 T74869 BF569767 BI599642 BG700585

AV650644 BM981746 BI770469 CA336043 CA390961 BI913330 BQ721037 BQ027202

BM677229 BM739814 AI268376 AL530994 AV653329 AI309739 CB128990 AI127324

AW243409 X05409 BQ083810 BF570286 AL563391 BM747449 AA435546 BE544889

BI917012 AA669031 BE049504 AL521490 BG328130 AL832043 BU682550 AW594477

AA384097 CD632609 BM818632 AI672769 AI418190 BQ373341 AI763276 Y00109

BM786119 AL559753 AX747497 AV701855 AI890849 AV646244 AV646965 BF115704

M54931 AA410613 BG980589 BG490346 AI815475 BG984725 AA037614 AV704569

AA012947 BQ693976 AL518832 BQ927465 BF968248 F27665 N40645 AV720989

AV653327 AA758787 AA319913 AV691479 BG900019 AW079838 N74405 AV721790

AW954725 BF826694 AV685898 W67378 T74921 BF314378 AV684856 BQ648530

BQ339092 AW264657 AA341546 AI131041 AA026147 BF114908 AI491735 AK021975

BG490305 BU623183 AA788867 BQ373340 AI092061 BQ718952 AV660163 CO245288

BM664881 AA404250 BE893574 AI951757 CB962070 BG707081 BI548184 BI497015

BM721621 AV693532 BQ324900 AW589517 CA394715 BG707510 AA345444 AW026717

BU570603 AV650656 BM544143 AA326036 CK823916 BE857218 BM981965 AW884076

AV707850 AV686137 AU120197 AI765605 BM744361 AI367322 AV652430 AI050927

R53432 BI765606 BG740249 AV687009 AL521592 BM012188 W67240 BQ353001

BP349729 AA738185 N89731 BM745881 BF206393 CB048182 AI004249 AI634926

W84741 AA496388 BQ315615 AV684344 H75881 AA705896 AV693007 BF314445

BF344529 AW821725 AA434407 BM906563 AA394012 AW294795 AV646976 BM729983

BQ353667 AW269253 AL045357 N92748 AV659016 AA017310 H75747 AA862409

BQ352997 AV694283 AW664614 BG370163 AL521489 BM144813 AA341892 W84766

BM011561 BM477788 AA977930 AL565353 CD102576 AL045358 CB267160 AL568263

BG705999 AW966987 AV691637 AV684039 AV684238 AA336569 W67263 T03708

BG899576 W19404 AA618520 AV687674 AW977100 AA604066 AI547271 AA669174

AA027226 BQ324100 AI907063 AI632515 BF335423 AW874009 AL531567 CD695889

BE049508 BQ339279 BI919205 BI226597 BI601649 AI351723 AW900642 R07512

T60310 AL548048 AV683922 AW136569 AA805610 AA243240 C75356 AA037613

R35319 AA404700 BG950099 AA568841 BM047696 T26508 BX410187 AA434505

AI610783 AV726621 CD357303 BQ352998 BQ353737 AL538753 BF035140 H42315

BQ679489 BQ682187 H41079 AL522211 BE786079 T95776 BQ324098 AV689772

AL521593 BI518173 AV658732 AA316472 AA013041 AV749998 BF754711 AW438690

BQ364637 C21226 BQ319167 BQ324097 AL581304 BX422479 BQ350772 N85268

BF854738 AW367449 BG538384 BF947255 T39905 AW953291 T55826 AL522847

BE259963 AW960865 T64759 BQ350990 BG370158 BG315393 H43081 H67138

T95777 BE168955 AL518833

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for ALDH2 About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4a	·	4b	^	5	^	6a	·	6b	^	7	^	8	^	9	^	10a	·	10b	^	11	^	12	^	13	^	14a	·	14b	·	14c
SP1:
SP2:					-
SP3:					-						-		-		-
SP4:																															-

ECgene alternative splicing isoforms for ALDH2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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ALDH2 expression in normal human tissues (normalized intensities) ALDH2 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: GTGGGTTGGC

About this image

ALDH2 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database
selected tissues (see all 17) fully expand


Brain (Nervous System) fully expand to see all 7 entries
Adult Endothelial Cells Blood Brain Barrier
Cerebral Cortex

Neural Tube (Nervous System) fully expand to see all 3 entries
Metencephalon

Blood (Hematopoietic System) fully expand to see all 2 entries
Monocytes Peripheral Blood

NULL (Uncategorized)
Adipose-derived stromal vascular fraction and adipocytes (HiQCell)

Testis (Reproductive System)
Leydig Cells Testis Interstitium

ALDH2 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

ALDH2 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.604551

Pathway & Disease-focused RT² Profiler PCR Arrays including ALDH2:

Fatty Acid Metabolism in human mouse rat

Amino Acid Metabolism II in human mouse rat

Drug Metabolism: Phase I Enzymes in human mouse rat

Stem Cells in human mouse rat

Molecular Toxicology PathwayFinder 384HT in human mouse rat

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of eukaryotes.

Orthologs for ALDH2 gene from Selected species (see all 24) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Aldh2^{1 , 5}	aldehyde dehydrogenase 2, mitochondrial^{1, 5}	86.82(n)¹ 95.54(a)¹		5 (61.86 cM)⁵ 11669¹ NM_009656.3¹ NP_033786.1¹ 121566027⁵
chicken (Gallus gallus)	Aves	ALDH2¹	aldehyde dehydrogenase 2 family (mitochondrial)	76.55(n) 85.85(a)		416880 XM_415171.4 XP_415171.3
lizard (Anolis carolinensis)	Reptilia	--	Uncharacterized protein	81(a)	1 → many	GL343282.1(19269-33915)
tropical clawed frog (Xenopus tropicalis)	Amphibia	aldh2¹	aldehyde dehydrogenase 2 family (mitochondrial)	72.81(n) 83(a)		448267 NM_001004907.1 NP_001004907.1
zebrafish (Danio rerio)	Actinopterygii	AY398308.1²	--	76.43(n)		AY398308.1
fruit fly (Drosophila melanogaster)	Insecta	CG3752³ Aldh¹	aldehyde dehydrogenase (NAD+)³ Aldehyde dehydrogenase¹	68(a)³ 68.27(n)¹ 71.54(a)¹		30B3³ 34256¹ NM_135441.2¹ NP_609285.1¹
worm (Caenorhabditis elegans)	Secernentea	alh-1¹	alh-1	61.75(n) 67.91(a)		175691 NM_065680.5 NP_498081.2
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	ALD5(YER073W)⁴ ALD5¹	Mitochondrial aldehyde dehydrogenase, involved in regulation more⁴ ALD5¹	52.01(n)¹ 47.52(a)¹		5(304030-305592)⁴ 856804^{1, 4} NP_010996.2¹ NP_010996.1⁴
thale cress (Arabidopsis thaliana)	eudicotyledons	ALDH2B4¹	ALDH2B4	58.88(n) 61.88(a)		823955 NM_114669.3 NP_190383.1
corn (Zea mays)	Liliopsida	AY106673.1²	--	73.81(n)		AY106673.1

ENSEMBL Gene Tree for ALDH2 (if available)
TreeFam Gene Tree for ALDH2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for ALDH2 gene

ALDH1L2² ALDH1A1² ENSG00000257767² ALDH1A2² ALDH1B1² ALDH7A1² ALDH6A1² ALDH8A1²

ALDH9A1² ALDH1A3² ALDH1L1²

13 SIMAP similar genes for ALDH2 using alignment to 8 protein entries: ALDH2_HUMAN (see all proteins):

ALDH1A2 ALDH1A1 ALDH1B1 ALDH1A3 DKFZp686G1675 ALDH1L1

ALDH9A1 ALDH1L2 ALDH8A1 ALDH5A1 ALDH6A1 ALDH7A1

ALDH3A1

ALDH2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Polymorphic Variants from UniProtKB/Swiss-Prot

ALDH2_HUMAN, P05091: Genetic variation in ALDH2 is responsible for individual differences in responses to drinking

alcohol [MIM:610251]. Allele ALDH2*2 is associated with a very high incidence of acute alcohol intoxication in

Orientals and South American Indians, as compared to Caucasians

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs671^1,2,,4	C,F,H	drug-response¹	112037845(+)	`ACACTG/AAAGTG`	4	/K /E	mis¹ ese³		26		MN CA NS EA NA	2426
rs55737128^1,2	C,F	--	111998816(+)	`GCCTCA/GCCTTC`	2	--	us2k¹		2		WA	120
rs149653753^1,2		--	111998866(+)	`CTAAT-/TGTG TGTGT`	2	--	us2k¹		0	--	--	--	--
rs60879478^1,2	C	--	111998867(+)	`TAATT-/G/GTGTGTGT GTGTGTGTGTGTGTGTGT`	4	--	us2k¹ cds¹		0	--	--	--	--
rs143259494^1,2		--	111998962(+)	`GGTCTC/TGAACT`	2	--	us2k¹		0	--	--	--	--
rs188946187^1,2		--	111998987(+)	`ATCTAA/CCCGCC`	2	--	us2k¹		0	--	--	--	--
rs147513328^1,2		--	111998990(+)	`TACCCA/GCCTCA`	2	--	us2k¹		0	--	--	--	--
rs193056481^1,2		--	111999047(+)	`AGCCTA/CATTTC`	2	--	us2k¹		0	--	--	--	--
rs185042017^1,2		--	111999278(+)	`TGGCAC/TGGTGG`	2	--	us2k¹		0	--	--	--	--
rs188250257^1,2		--	111999335(+)	`CACCTA/GAGGTC`	2	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ALDH2 (112204691 - 112247789 bp)

Structural Variations
Database of Genomic Variants (DGV) 4 variations for ALDH2: About this table

Variant ID	Type	Subtype	PubMed ID
nsv515716	CNV	Gain	19592680
nsv470317	CNV	Gain	18288195
dgv1492n71	CNV	Gain	21882294
nsv455715	CNV	Gain	19166990

Human Gene Mutation Database (HGMD): ALDH2
Locus Specific Mutation Databases (LSDB): ALDH2

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing ALDH2

DNA2.0 Custom Variant and Variant Library Synthesis for ALDH2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 100650
OMIM disorders: 610251
Selected diseases for ALDH2 (see all 91):    About MalaCards

sublingual nitroglycerin poor response to esophageal cancer, alcohol-related hangover alcohol sensitivity, acute

alcoholic neuropathy alcoholic liver cirrhosis alcoholic cardiomyopathy oral cavity cancer

alcohol abuse fetal alcohol syndrome gout esophageal squamous cell carcinoma

alcohol dependence antisocial personality disorder liver cirrhosis atrophic gastritis

retinopathy of prematurity stomach cancer cardiovascular disease risk factor gastroduodenitis

5 diseases from the University of Copenhagen DISEASES database for ALDH2:

Alcohol dependence Esophageal cancer Substance abuse Liver disease

Squamous cell carcinoma

ALDH2 for disorders About GeneDecksing

Congresses - knowledge worth sharing:
Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

Selected Novoseek inferred disease relationships for ALDH2 gene (see all 56) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
alcoholism	83.4	127	7625477 (5), 10803776 (4), 1492799 (4), 7573775 (3) (see all 59)
liver diseases alcoholic	66.3	20	11410736 (5), 15519646 (2), 8986242 (1), 8591846 (1) (see all 10)
pancreatitis alcoholic	60.7	7	11117576 (2), 8985275 (1), 8986224 (1), 10235286 (1) (see all 5)
alcohol abuse	56.6	2	19251111 (1)
alcoholic cirrhosis	54.8	7	12824748 (1), 15220553 (1), 8845660 (1), 11748356 (1) (see all 5)
alcoholic neuropathy	52.6	3	15182962 (2), 15542751 (1)
macrocytosis	51.1	2	16759795 (1), 17295873 (1)
smoking habit	47.2	9	15714130 (3), 18216179 (2), 8903472 (2), 17207821 (1)
carcinoma squamous cell	43.5	18	16759795 (2), 16639733 (2), 16499490 (2), 18322963 (2) (see all 12)
genetic susceptibility	41.6	1	19449376 (1)

Genatlas disease: ALDH2

facial flushing reaction to alcohol

Genetic Association Database (GAD): ALDH2
Human Genome Epidemiology (HuGE) Navigator: ALDH2 (303 documents)

Export disorders for ALDH2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for ALDH2 gene, integrated from 10 sources (see all 699):
(articles sorted by number of sources associating them with ALDH2)

Utopia: connect your pdf to the dynamic
world of online information

Cloning of cDNAs for human aldehyde dehydrogenases 1 and 2. (PubMed id 2987944)^{1, 2, 3} Hsu L.C.... Yoshida A. (Proc. Natl. Acad. Sci. U.S.A. 1985)
Molecular abnormality and cDNA cloning of human aldehyde dehydrogenases. (PubMed id 4015823)^{1, 2, 3} Yoshida A.... Tani K. (Alcohol 1985)
Meta-analysis of three diabetes population studies: association of inactive ALDH2 genotype with maternal inheritance of diabetes. (PubMed id 15563966)^{1, 4, 9} Murata C....Suzuki Y. (Diabetes Res. Clin. Pract. 2004)
Association between personality traits and ALDH2 polymorphism in Japanese male alcoholics. (PubMed id 19298328)^{1, 4, 9} Kimura M....Kashima H. (Alcohol. Clin. Exp. Res. 2009)
Genetic association between aldehyde dehydrogenase 2 (ALDH2) variation and high-density lipoprotein cholesterol (HDL-C) among non-drinkers in two large population samples in Japan. (PubMed id 18776700)^{1, 4, 9} Wada M....Kato T. (J. Atheroscler. Thromb. 2008)
Aldehyde dehydrogenase-2 genotypes and HLA haplotypes in Japanese patients with esophageal cancer. (PubMed id 12168074)^{1, 4, 9} Watanabe S....Kuriyama S. (Oncol. Rep. 2002)
Salivary acetaldehyde concentration according to alcoholic beverage consumed and aldehyde dehydrogenase-2 genotype. (PubMed id 18616675)^{1, 4, 9} Yokoyama A....Yokoyama T. (Alcohol. Clin. Exp. Res. 2008)
Aldehyde dehydrogenase 2 and beta3-adrenergic receptor gene polymorphisms: their association with elevated liver enzymes and metabolic syndrome. (PubMed id 14506613)^{1, 4, 9} Murata C....Okazaki I. (Metab. Clin. Exp. 2003)
Genetic polymorphisms in cytochrome P4502E1, alcohol and aldehyde dehydrogenases and the risk of esophageal squamous cell carcinoma in Gansu Chinese males. (PubMed id 18322963)^{1, 4, 9} Guo Y.M....Guo Q.H. (World J. Gastroenterol. 2008)
Interactive effects of lifetime alcohol consumption and alcohol and aldehyde dehydrogenase polymorphisms on esophageal cancer risks. (PubMed id 17036331)^{1, 4, 9} Chen Y.J....Wu M.T. (Int. J. Cancer 2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 217	HGNC: 404	AceView: ALDH2andACAD10	Ensembl:ENSG00000111275	euGenes: HUgn217
ECgene: ALDH2	Kegg: 217	H-InvDB: ALDH2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for ALDH2	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for ALDH2	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for ALDH2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for ALDH2 gene:
Search GeneIP for patents involving ALDH2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALDH2

	SwitchGear 3'UTR luciferase reporter plasmids for ALDH2
	SwitchGear Promoter luciferase reporter plasmids for ALDH2

ThermoFisher Antibody for ALDH2

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALDH2

	inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ALDH2
	inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ALDH2

LSBio Antibodies in human, mouse, rat for ALDH2

Customized transgenic rodents for:

	Humanization
	Biomarker expression
	Off-target effect monitoring
	Translational medicine
	Tissue-specific gene expresssion
	Time-controlled gene expresssion

Browse compounds at ApexBio

GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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Hot genes Disease genes ALDH2 gene at Home site.

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ALDH2 Gene

Aldehyde Dehydrogenase 2 Family (Mitochondrial)

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ALDH2 Human Recombinant Protein Products:

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ALDH2 Gene

Aldehyde Dehydrogenase 2 Family (Mitochondrial)

Aliasesfor ALDH2 gene

Summariesfor ALDH2 gene

Genomic Viewsfor ALDH2 gene

Proteinsfor ALDH2 gene

ALDH2 Human Recombinant Protein Products:

ALDH2 Antibody Products:

ALDH2 Assay Products:

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Functionfor ALDH2 gene

Localizationfor ALDH2 gene

Pathways & Interactionsfor ALDH2 gene

Drugs & Compoundsfor ALDH2 gene

Transcriptsfor ALDH2 gene

Expression for ALDH2 gene

Orthologsfor ALDH2 gene

Paralogsfor ALDH2 gene

Genomic Variantsfor ALDH2 gene

Disorders / Diseasesfor ALDH2 gene

Publicationsfor ALDH2 gene

External Searches for ALDH2 gene

Genome Databases showing ALDH2 gene

Other Databases showing ALDH2 gene

Specialized Databases showing ALDH2 gene

Intellectual Propertyfor ALDH2 gene

Productsfor ALDH2 gene

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Aliases
for ALDH2 gene

Summaries
for ALDH2 gene

Genomic Views
for ALDH2 gene

Proteins
for ALDH2 gene

Domains /
Families
for ALDH2 gene

Function
for ALDH2 gene

Localization
for ALDH2 gene

Pathways & Interactions
for ALDH2 gene

Drugs & Compounds
for ALDH2 gene

Transcripts
for ALDH2 gene

Expression
for ALDH2 gene

Orthologs
for ALDH2 gene

Paralogs
for ALDH2 gene

Genomic Variants
for ALDH2 gene

Disorders / Diseases
for ALDH2 gene

Publications
for ALDH2 gene

Intellectual Property
for ALDH2 gene

Products
for ALDH2 gene