Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



ALDH2 Gene

protein-coding   GIFtS: 74
GCID: GC12P112205

Aldehyde Dehydrogenase 2 Family (Mitochondrial)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Aldehyde Dehydrogenase 2 Family (Mitochondrial)1 2     Acetaldehyde Dehydrogenase 22
ALDH-E22 3     Aldehyde Dehydrogenase, Mitochondrial2
ALDHI2 3     Liver Mitochondrial ALDH2
ALDM2 3     Nucleus-Encoded Mitochondrial Aldehyde Dehydrogenase 22
ALDH Class 22 3     EC 1.2.18
EC 1.2.1.33 8     

External Ids:    HGNC: 4041   Entrez Gene: 2172   Ensembl: ENSG000001112757   OMIM: 1006505   UniProtKB: P050913   

Export aliases for ALDH2 gene to outside databases

Previous GC identifers: GC12P111101 GC12P111726 GC12P111987 GC12P110616 GC12P110667 GC12P109217


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for ALDH2 Gene:
This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme
of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase,
cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and
subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Orientals have the
cytosolic isozyme but not the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication
among Orientals than among Caucasians could be related to the absence of a catalytically active form of the
mitochondrial isozyme. The increased exposure to acetaldehyde in individuals with the catalytically inactive form
may also confer greater susceptibility to many types of cancer. This gene encodes a mitochondrial isoform, which
has a low Km for acetaldehydes, and is localized in mitochondrial matrix. Alternative splicing results in
multiple transcript variants encoding distinct isoforms.(provided by RefSeq, Mar 2011)

GeneCards Summary for ALDH2 Gene:
ALDH2 (aldehyde dehydrogenase 2 family (mitochondrial)) is a protein-coding gene. Diseases associated with ALDH2 include sublingual nitroglycerin poor response to, and esophageal cancer, alcohol-related. GO annotations related to this gene include electron carrier activity and aldehyde dehydrogenase [NAD(P)+] activity. An important paralog of this gene is ALDH1L2.

summary for ALDH2 Gene:
Aldehyde dehydrogenase enzymes oxidize aldehydes to generate carboxylic acids for use in the muscle and
heart. Numerous aldehyde dehydrogenase genes exist, of which ALDH2 is best known for its role in alcohol
oxidation. Over 550 aldehyde genes have been identified across different species, which can be split into
numerous families. There are 19 known human aldehyde dehydrogenase genes. ALDH2, a human mitochondrial
enzyme belonging to family 2, is responsible for breaking down acetaldehyde produced by ethanol. Inhibition
of aldehyde dehydrogenase therefore results in the build-up of acetaldehyde, a toxic metabolite which is
thought to be responsible for 'hangover' symptoms.

Gene Wiki entry for ALDH2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000012.12  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the ALDH2 gene promoter:
         PPAR-alpha   PPAR-gamma1   Sp1   p53   FOXJ2 (long isoform)   FOXJ2   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ALDH2 promoter sequence
   Search Chromatin IP Primers for ALDH2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ALDH2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24.2   Ensembl cytogenetic band:  12q24.12   HGNC cytogenetic band: 12q24.12

ALDH2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ALDH2 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P112205:  view genomic region     (about GC identifiers)

Start:
112,204,691 bp from pter      End:
112,247,789 bp from pter
Size:
43,099 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: ALDH2_HUMAN, P05091 (See protein sequence)
Recommended Name: Aldehyde dehydrogenase, mitochondrial precursor  
Size: 517 amino acids; 56381 Da
Subunit: Homotetramer
Sequence caution: Sequence=AAA62825.1; Type=Frameshift; Positions=424, 444, 448, 461; Sequence=CAA68290.1;
Type=Frameshift; Positions=Several; Sequence=CAA68290.1; Type=Miscellaneous discrepancy;
Selected PDB 3D structures from and Proteopedia for ALDH2 (see all 24):
1CW3 (3D)        1NZW (3D)        1NZX (3D)        1NZZ (3D)        1O00 (3D)        1O01 (3D)    
Secondary accessions: B4DW54 E7EUE5 Q03639 Q6IB13 Q6IV71
Alternative splicing: 2 isoforms:  P05091-1   P05091-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ALDH2: NX_P05091

Explore proteomics data for ALDH2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for ALDH2 (P05091) (see all 36)
     TLELGGK  WKLGPAL  AGSRTFV  VTLELGG 


    See ALDH2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_000681.2  NP_001191818.1  

    ENSEMBL proteins: 
     ENSP00000403349   ENSP00000261733   ENSP00000448179   ENSP00000474669  
    Reactome Protein details: P05091

    ALDH2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for ALDH2
    OriGene Protein Over-expression Lysate for ALDH2
    OriGene MassSpec for ALDH2
    OriGene Custom Protein Services for ALDH2
    GenScript Custom Purified and Recombinant Proteins Services for ALDH2
    Novus Biologicals ALDH2 Proteins
    Novus Biologicals ALDH2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for ALDH2
    Browse Proteins at Cloud-Clone Corp.

    ALDH2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for ALDH2
    OriGene Custom Antibody Services for ALDH2
    Novus Biologicals ALDH2 Antibodies
    Abcam antibodies for ALDH2
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for ALDH2
    LSBio Antibodies in human, mouse, rat for ALDH2

    ALDH2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ALDH2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ALDH2
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    ALDH: Aldehyde dehydrogenases

    5 InterPro protein domains:
     IPR016163 Ald_DH_C
     IPR016162 Ald_DH_N
     IPR016161 Ald_DH/histidinol_DH
     IPR015590 Aldehyde_DH_dom
     IPR016160 Ald_DH_CS

    Graphical View of Domain Structure for InterPro Entry P05091

    ProtoNet protein and cluster: P05091

    2 Blocks protein domains:
    IPB001484 Pyrokinin
    IPB002086 Aldehyde dehydrogenase


    UniProtKB/Swiss-Prot: ALDH2_HUMAN, P05091
    Similarity: Belongs to the aldehyde dehydrogenase family


    ALDH2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ALDH2_HUMAN, P05091
    Catalytic activity: An aldehyde + NAD(+) + H(2)O = a carboxylate + NADH

         Genatlas biochemistry entry for ALDH2:
    aldehyde dehydrogenase 2,mitochondrial,E2 isoform

         Enzyme Numbers (IUBMB): EC 1.2.1.31 2 EC 1.2.12

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004029aldehyde dehydrogenase (NAD) activity EXP--
    GO:0004030aldehyde dehydrogenase [NAD(P)+] activity TAS8903321
    GO:0009055electron carrier activity TAS8903321
    GO:0016491oxidoreductase activity ----
         
    ALDH2 for ontologies           About GeneDecksing


    Phenotypes:
         15 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Aldh2):
     behavior/neurological  cellular  growth/size/body  hematopoietic system  homeostasis/metabolism 
     immune system  integument  limbs/digits/tail  mortality/aging  nervous system 
     other  reproductive system  skeleton  tumorigenesis  vision/eye 

    ALDH2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Aldh2tm1Kaw for ALDH2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ALDH2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ALDH2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ALDH2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ALDH2

    miRNA
    Products:
        
    miRTarBase miRNAs that target ALDH2:
    hsa-mir-615-3p (MIRT039939), hsa-mir-16-5p (MIRT031438), hsa-mir-1 (MIRT023536), hsa-mir-335-5p (MIRT016754)

    Block miRNA regulation of human, mouse, rat ALDH2 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate ALDH2
    SwitchGear 3'UTR luciferase reporter plasmidALDH2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ALDH2
    Predesigned siRNA for gene silencing in human, mouse, rat ALDH2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ALDH2

    Clone
    Products:
         
    OriGene clones in human, mouse for ALDH2 (see all 7)
    OriGene ORF clones in mouse, rat for ALDH2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ALDH2 (NM_000690)
    Sino Biological Human cDNA Clone for ALDH2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ALDH2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALDH2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ALDH2
    Browse ESI BIO Cell Lines and PureStem Progenitors for ALDH2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALDH2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    ALDH2_HUMAN, P05091: Mitochondrion matrix
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    cytosol2
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005759mitochondrial matrix TAS--
    GO:0070062extracellular vesicular exosome IDA19056867

    ALDH2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for ALDH2 About   (see all 22)  
    See pathways by source

    SuperPathContained pathways About
    1Cytochrome P450 - arranged by substrate type
    Phase 1 - Functionalization of compounds0.75
    Fatty Acid Omega Oxidation0.00
    Ethanol oxidation0.00
    2Tryptophan metabolism
    Tryptophan metabolism0.46
    Tryptophan metabolism0.46
    3Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    4beta-Alanine metabolism
    beta-Alanine metabolism
    phenylethylamine degradation I0.00
    5Transmission across Chemical Synapses
    Transmission across Chemical Synapses0.72
    Neurotransmitter Clearance In The Synaptic Cleft0.00
    Neuronal System0.68

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for ALDH2
        Retinol metabolism

    Selected BioSystems Pathways for ALDH2 (see all 13)
        oxidative ethanol degradation III
    ethanol degradation II
    ethanol degradation IV
    serotonin degradation
    noradrenaline and adrenaline degradation


    2 Reactome Pathways for ALDH2
        Metabolism of serotonin
    Ethanol oxidation

    2 PharmGKB Pathways for ALDH2
        Cyclophosphamide Pathway, Pharmacodynamics
    Ifosfamide Pathway, Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for ALDH2) (see all 14):
        Glycolysis / Gluconeogenesis
    Pentose and glucuronate interconversions
    Ascorbate and aldarate metabolism
    Fatty acid degradation
    Valine, leucine and isoleucine degradation

    UniProtKB/Swiss-Prot: ALDH2_HUMAN, P05091
    Pathway: Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2


    ALDH2 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ALDH2: 

              Fatty Acid Metabolism in human mouse rat
              Amino Acid Metabolism II in human mouse rat
              Drug Metabolism: Phase I Enzymes in human mouse rat
              Stem Cells in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ALDH2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ALDH2 (P050912, 3 ENSP000002617334) via UniProtKB, MINT, STRING, and/or I2D (see all 331)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    C14orf1Q9UKR52, 3MINT-63389 I2D: score=5 
    SLC35F6Q8N3572, 3MINT-63388 I2D: score=5 
    UNC119Q134322, 3MINT-63385 I2D: score=5 
    CRMP1Q141942, 3MINT-63386 I2D: score=4 
    IGSF21Q96ID52, 3MINT-63387 I2D: score=4 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS8903321
    GO:0006066alcohol metabolic process TAS1306115
    GO:0006068ethanol catabolic process IEA--
    GO:0006069ethanol oxidation TAS--
    GO:0006805xenobiotic metabolic process TAS--

    ALDH2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for ALDH2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    WIN 18446ALDH1a2 inhibitor[1477-57-2]
    Alda 1ALDH2 activator; cardioprotective[349438-38-6]

    Selected HMDB Compounds for ALDH2 (see all 43)    About this table
    CompoundSynonyms CAS #PubMed Ids
    (S)-Methylmalonic acid semialdehyde(S)-Methylmalonate semialdehyde (see all 3)99043-16-0--
    2-Methyl-3-oxopropanoic acid2-Methyl-3-oxopropanoate (see all 7)6236-08-4--
    2-Propyn-1-al ----
    20-Oxo-leukotriene E420-oxo-LTE(,4) (see all 3)----
    20-oxo-leukotriene B420-carboxyleukotriene B4 ----
    3-Aminopropionaldehyde3-Aminopropanal (see all 3)352-92-1--
    3-Butyn-1-al 52844-23-2--
    3a,7a-Dihydroxy-5b-cholestan-26-al3a,7a-Dihydroxy-5b-cholestan-26-al;3alpha,7alpha-dihydroxy-5beta-cholestan-27-al;5beta-cholestane-3alpha,7alpha-diol-27-al;5beta-cholestan-27-al-3alpha,7alpha-diol ----
    3a,7a-Dihydroxycoprostanic acid3a,7a-Dihydroxy-5b-cholestan-26-oate (see all 14)17974-66-2--
    4-Acetamidobutanoic acidN-Acetyl-4-aminobutanoate (see all 11)3025-96-5--

    10 DrugBank Compounds for ALDH2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Daidzin4',7-Dihydroxyisoflavone (see all 8)552-66-9target--17139284 17016423 10592235
    Nicotinamide-Adenine-Dinucleotide-- 53-84-9target--17139284 17016423 10592235
    Crotonaldehyde-- --target--17139284 17016423
    DisulfiramDisulfuram (see all 16)97-77-8targetinhibitor17220694 16051882
    GuanidineAminomethanamidine (see all 9)113-00-8target--17139284 17016423
    NADHbeta-DPNH (see all 18)606-68-8target--17488809 16961761
    Amyl NitriteAmyl nitrosum (see all 6)110-46-3enzymesubstrate20543077
    Benzyl alcohol(Hydroxymethyl)benzene (see all 10)100-51-6enzymesubstrate7645026
    Nitric Oxide-- 10102-43-9enzymeinhibitor16242127
    NitroglycerinGlyceryl trinitrate (see all 7)55-63-0enzymesubstrate20543077

    Selected Novoseek inferred chemical compound relationships for ALDH2 gene (see all 61)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    acetaldehyde 93.7 268 16365683 (5), 18616675 (4), 16403513 (4), 14722101 (4) (see all 99)
    daidzin 75.3 28 8433985 (3), 11563931 (3), 9050837 (3), 18613661 (3) (see all 9)
    ethanol 75.2 116 19144977 (4), 16316071 (3), 10826103 (3), 8512495 (3) (see all 58)
    propionaldehyde 67.3 2 15703303 (1), 17655326 (1)
    nitroglycerin 63.4 83 17585900 (5), 16051882 (5), 18272654 (3), 16440063 (3) (see all 21)
    retinaldehyde 62 1 10559215 (1)
    aldophosphamide 61.2 2 1610409 (2)
    rsai 58.1 2 15318112 (1), 11696658 (1)
    disulfiram 56.1 8 17980785 (2), 9605433 (2), 9354647 (2), 16051882 (1) (see all 5)
    betaine aldehyde 54.7 1 1527093 (1)



    ALDH2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for ALDH2 gene (2 alternative transcripts): 
    NM_000690.3  NM_001204889.1  

    Unigene Cluster for ALDH2:

    Aldehyde dehydrogenase 2 family (mitochondrial)
    Hs.604551  [show with all ESTs]
    Unigene Representative Sequence: NM_000690
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000416293 ENST00000261733(uc001tst.3 uc010syi.2) ENST00000548536
    ENST00000549106
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ALDH2 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate ALDH2
    SwitchGear 3'UTR luciferase reporter plasmidALDH2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ALDH2
    Predesigned siRNA for gene silencing in human, mouse, rat ALDH2
    Clone
    Products:
         
    OriGene clones in human, mouse for ALDH2 (see all 7)
    OriGene ORF clones in mouse, rat for ALDH2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ALDH2 (NM_000690)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ALDH2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALDH2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ALDH2
    OriGene qSTAR qPCR primer pairs in human, mouse for ALDH2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ALDH2
      QuantiTect SYBR Green Assays in human, mouse, rat ALDH2
      QuantiFast Probe-based Assays in human, mouse, rat ALDH2

    Additional mRNA sequence: 

    AK223373.1 AK301375.1 AK314856.1 AY621070.1 BC002967.1 BC071839.1 CR456991.1 K03001.1 
    M26760.1 M54931.1 S80262.1 X05409.1 Y00109.1 

    24 DOTS entries:

    DT.100825560  DT.219231  DT.100825566  DT.100825563  DT.100030509  DT.100825574  DT.92458180  DT.95159151 
    DT.100825577  DT.121177828  DT.92458189  DT.95159142  DT.95159145  DT.100825568  DT.121177818  DT.121177839 
    DT.92458178  DT.95159116  DT.100825562  DT.121177767  DT.121177793  DT.95159148  DT.92018440  DT.92458173 

    Selected AceView cDNA sequences (see all 651):

    BC015056 BG696274 AI056873 AI460073 AA969786 AW188884 AV650553 AI186384 
    AA419072 T08954 AA243179 BI834562 BQ631709 BP871792 CA424936 BG056829 
    BM765982 CR617194 AI632521 BM784372 BM664828 BU151478 BU849300 BQ362166 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ALDH2    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14a · 14b · 14c
    SP1:                                                                                                                        
    SP2:              -                                                                                                         
    SP3:              -                 -     -     -                                                                           
    SP4:                                                                                            -                           


    ECgene alternative splicing isoforms for ALDH2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    ALDH2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGGGTTGGC
    ALDH2 Expression
    About this image


    ALDH2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 17) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Adult Endothelial Cells Blood Brain Barrier
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Monocytes Peripheral Blood
     
     NULL (Uncategorized)
             Adipose-derived stromal vascular fraction and adipocytes (HiQCell)
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    ALDH2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ALDH2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.604551
        Pathway & Disease-focused RT2 Profiler PCR Arrays including ALDH2: 
              Fatty Acid Metabolism in human mouse rat
              Amino Acid Metabolism II in human mouse rat
              Drug Metabolism: Phase I Enzymes in human mouse rat
              Stem Cells in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for ALDH2
    OriGene qSTAR qPCR primer pairs in human, mouse for ALDH2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ALDH2
    QuantiTect SYBR Green Assays in human, mouse, rat ALDH2
    QuantiFast Probe-based Assays in human, mouse, rat ALDH2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALDH2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ALDH2 gene from Selected species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Aldh21 , 5 aldehyde dehydrogenase 2, mitochondrial1, 5 86.82(n)1
    95.54(a)1
      5 (61.86 cM)5
    116691  NM_009656.31  NP_033786.11 
     1215660275 
    chicken
    (Gallus gallus)
    Aves ALDH21 aldehyde dehydrogenase 2 family (mitochondrial) 76.55(n)
    85.85(a)
      416880  XM_415171.4  XP_415171.3 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    81(a)
    1 → many
    GL343282.1(19269-33915)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia aldh21 aldehyde dehydrogenase 2 family (mitochondrial) 72.81(n)
    83(a)
      448267  NM_001004907.1  NP_001004907.1 
    zebrafish
    (Danio rerio)
    Actinopterygii AY398308.12   -- 76.43(n)    AY398308.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG37523
    Aldh1
    aldehyde dehydrogenase (NAD+)3
    Aldehyde dehydrogenase1
    68(a)3
    68.27(n)1
    71.54(a)1
      30B33
    342561  NM_135441.21  NP_609285.11 
    worm
    (Caenorhabditis elegans)
    Secernentea alh-11 alh-1 61.75(n)
    67.91(a)
      175691  NM_065680.5  NP_498081.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ALD5(YER073W)4
    ALD51
    Mitochondrial aldehyde dehydrogenase, involved in regulation more4
    ALD51
    52.01(n)1
    47.52(a)1
      5(304030-305592)4
    8568041, 4  NP_010996.21  NP_010996.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ALDH2B41 ALDH2B4 58.88(n)
    61.88(a)
      823955  NM_114669.3  NP_190383.1 
    corn
    (Zea mays)
    Liliopsida AY106673.12   -- 73.81(n)    AY106673.1 


    ENSEMBL Gene Tree for ALDH2 (if available)
    TreeFam Gene Tree for ALDH2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for ALDH2 gene
    ALDH1L22  ALDH1A12  ENSG000002577672  ALDH1A22  ALDH1B12  ALDH7A12  ALDH6A12  ALDH8A12  
    ALDH9A12  ALDH1A32  ALDH1L12  
    13 SIMAP similar genes for ALDH2 using alignment to 8 protein entries:     ALDH2_HUMAN (see all proteins):
    ALDH1A2    ALDH1A1    ALDH1B1    ALDH1A3    DKFZp686G1675    ALDH1L1
    ALDH9A1    ALDH1L2    ALDH8A1    ALDH5A1    ALDH6A1    ALDH7A1
    ALDH3A1

    ALDH2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Polymorphic Variants from UniProtKB/Swiss-Prot
    ALDH2_HUMAN, P05091: Genetic variation in ALDH2 is responsible for individual differences in responses to drinking
    alcohol [MIM:610251]. Allele ALDH2*2 is associated with a very high incidence of acute alcohol intoxication in
    Orientals and South American Indians, as compared to Caucasians


    Selected SNPs for ALDH2 (see all 840)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs6711,2,,4
    C,F,Hdrug-response1112037845(+) ACACTG/AAAGTG 4 /K /E mis1 ese326Minor allele frequency- A:0.12MN CA NS EA NA 2426
    rs557371281,2
    C,F--111998816(+) GCCTCA/GCCTTC 2 -- us2k12Minor allele frequency- G:0.09WA 120
    rs1496537531,2
    --111998866(+) CTAAT-/TGTG  
            
    TGTGT
    2 -- us2k10--------
    rs608794781,2
    C--111998867(+) TAATT-/G/GTGTGTGT
    GTGTGTGTGTGTG
    TGTGT
    4 -- us2k1 cds10--------
    rs1432594941,2
    --111998962(+) GGTCTC/TGAACT 2 -- us2k10--------
    rs1889461871,2
    --111998987(+) ATCTAA/CCCGCC 2 -- us2k10--------
    rs1475133281,2
    --111998990(+) TACCCA/GCCTCA 2 -- us2k10--------
    rs1930564811,2
    --111999047(+) AGCCTA/CATTTC 2 -- us2k10--------
    rs1850420171,2
    --111999278(+) TGGCAC/TGGTGG 2 -- us2k10--------
    rs1882502571,2
    --111999335(+) CACCTA/GAGGTC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for ALDH2 (112204691 - 112247789 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ALDH2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv515716CNV Gain19592680
    nsv470317CNV Gain18288195
    dgv1492n71CNV Gain21882294
    nsv455715CNV Gain19166990

    Human Gene Mutation Database (HGMD): ALDH2
    Locus Specific Mutation Databases (LSDB): ALDH2

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ALDH2
    DNA2.0 Custom Variant and Variant Library Synthesis for ALDH2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 100650   
    OMIM disorders: 610251  
    Selected diseases for ALDH2 (see all 91):    
    About MalaCards
    sublingual nitroglycerin poor response to    esophageal cancer, alcohol-related    hangover    alcohol sensitivity, acute
    alcoholic neuropathy    alcoholic liver cirrhosis    alcoholic cardiomyopathy    oral cavity cancer
    alcohol abuse    fetal alcohol syndrome    gout    esophageal squamous cell carcinoma
    alcohol dependence    antisocial personality disorder    liver cirrhosis    atrophic gastritis
    retinopathy of prematurity    stomach cancer    cardiovascular disease risk factor    gastroduodenitis

    5 diseases from the University of Copenhagen DISEASES database for ALDH2:
    Alcohol dependence     Esophageal cancer     Substance abuse     Liver disease
    Squamous cell carcinoma

    ALDH2 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for ALDH2 gene (see all 56)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    alcoholism 83.4 127 7625477 (5), 10803776 (4), 1492799 (4), 7573775 (3) (see all 59)
    liver diseases alcoholic 66.3 20 11410736 (5), 15519646 (2), 8986242 (1), 8591846 (1) (see all 10)
    pancreatitis alcoholic 60.7 7 11117576 (2), 8985275 (1), 8986224 (1), 10235286 (1) (see all 5)
    alcohol abuse 56.6 2 19251111 (1)
    alcoholic cirrhosis 54.8 7 12824748 (1), 15220553 (1), 8845660 (1), 11748356 (1) (see all 5)
    alcoholic neuropathy 52.6 3 15182962 (2), 15542751 (1)
    macrocytosis 51.1 2 16759795 (1), 17295873 (1)
    smoking habit 47.2 9 15714130 (3), 18216179 (2), 8903472 (2), 17207821 (1)
    carcinoma squamous cell 43.5 18 16759795 (2), 16639733 (2), 16499490 (2), 18322963 (2) (see all 12)
    genetic susceptibility 41.6 1 19449376 (1)

    Genatlas disease: ALDH2
    facial flushing reaction to alcohol

    Genetic Association Database (GAD): ALDH2
    Human Genome Epidemiology (HuGE) Navigator: ALDH2 (303 documents)

    Export disorders for ALDH2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for ALDH2 gene, integrated from 10 sources (see all 699) (see top 10):
    (articles sorted by number of sources associating them with ALDH2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of cDNAs for human aldehyde dehydrogenases 1 and 2. (PubMed id 2987944)1, 2, 3 Hsu L.C.... Yoshida A. (Proc. Natl. Acad. Sci. U.S.A. 1985)
    2. Molecular abnormality and cDNA cloning of human aldehyde dehydrogenases. (PubMed id 4015823)1, 2, 3 Yoshida A.... Tani K. (Alcohol 1985)
    3. Meta-analysis of three diabetes population studies: association of inactive ALDH2 genotype with maternal inheritance of diabetes. (PubMed id 15563966)1, 4, 9 Murata C....Suzuki Y. (Diabetes Res. Clin. Pract. 2004)
    4. Association between personality traits and ALDH2 polymorphism in Japanese male alcoholics. (PubMed id 19298328)1, 4, 9 Kimura M....Kashima H. (Alcohol. Clin. Exp. Res. 2009)
    5. Genetic association between aldehyde dehydrogenase 2 (ALDH2) variation and high-density lipoprotein cholesterol (HDL-C) among non-drinkers in two large population samples in Japan. (PubMed id 18776700)1, 4, 9 Wada M....Kato T. (J. Atheroscler. Thromb. 2008)
    6. Aldehyde dehydrogenase-2 genotypes and HLA haplotypes in Japanese patients with esophageal cancer. (PubMed id 12168074)1, 4, 9 Watanabe S....Kuriyama S. (Oncol. Rep. 2002)
    7. Salivary acetaldehyde concentration according to alcoholic beverage consumed and aldehyde dehydrogenase-2 genotype. (PubMed id 18616675)1, 4, 9 Yokoyama A....Yokoyama T. (Alcohol. Clin. Exp. Res. 2008)
    8. Aldehyde dehydrogenase 2 and beta3-adrenergic receptor gene polymorphisms: their association with elevated liver enzymes and metabolic syndrome. (PubMed id 14506613)1, 4, 9 Murata C....Okazaki I. (Metab. Clin. Exp. 2003)
    9. Genetic polymorphisms in cytochrome P4502E1, alcohol and aldehyde dehydrogenases and the risk of esophageal squamous cell carcinoma in Gansu Chinese males. (PubMed id 18322963)1, 4, 9 Guo Y.M....Guo Q.H. (World J. Gastroenterol. 2008)
    10. Interactive effects of lifetime alcohol consumption and alcohol and aldehyde dehydrogenase polymorphisms on esophageal cancer risks. (PubMed id 17036331)1, 4, 9 Chen Y.J....Wu M.T. (Int. J. Cancer 2006)
    11. Esophageal squamous cell carcinoma and aldehyde dehydrogenase-2 genotypes in Japanese females. (PubMed id 16499490)1, 4, 9 Yokoyama A....Watanabe H. (Alcohol. Clin. Exp. Res. 2006)
    12. ALDH2 and CYP2E1 genotypes, urinary acetaldehyde excretion and the health consequences in moderate alcohol consumers. (PubMed id 16365683)1, 4, 9 Yamada Y....Honda R. (J. Hum. Genet. 2006)
    13. Gene-environment interaction between an aldehyde dehydrogenase-2 (ALDH2) polymorphism and alcohol consumption for the risk of esophageal cancer. (PubMed id 11375898)1, 4, 9 Matsuo K....Tajima K. (Carcinogenesis 2001)
    14. Absence of association on aldehyde dehydrogenase 2 (ALDH2) polymorphism with Mongolian Alzheimer patients. (PubMed id 19914339)1, 4, 9 Zhou S....Ma X. (Neurosci. Lett. 2010)
    15. MAOA-uVNTR polymorphism may modify the protective effect of ALDH2 gene against alcohol dependence in antisocial personality disorder. (PubMed id 19302089)1, 4, 9 Lee S.Y....Lu R.B. (Alcohol. Clin. Exp. Res. 2009)
    16. Associations of ALDH2 and ADH1B genotypes with alcohol-related phenotypes in Asian young adults. (PubMed id 19298323)1, 4, 9 Hendershot C.S....Larimer M.E. (Alcohol. Clin. Exp. Res. 2009)
    17. Association of ALDH2 polymorphism with sensitivity to acetaldehyde-induced micronuclei and facial flushing after alcohol intake. (PubMed id 15840430)1, 4, 9 Kim J.S....Chung H.W. (Toxicology 2005)
    18. ALDH2/ADH2 polymorphism associated with vasculopathy and neuropathy in type 2 diabetes. (PubMed id 15318096)1, 4, 9 Suzuki Y....Matsuoka K. (Alcohol. Clin. Exp. Res. 2004)
    19. Influence of NQO1, ALDH2, and CYP2E1 genetic polymorphisms, smoking, and alcohol drinking on the risk of lung cancer in Koreans. (PubMed id 18798003)1, 4, 9 Eom S.Y....Kim H. (amp 2009)
    20. [Genetic polymorphisms of alcohol dehydrogenase-2 and aldehyde dehydrogenase-2 associated with the susceptibility on esophageal cancer]. (PubMed id 19799139)1, 4, 9 Ding J.H....Yao G.H. (Zhonghua Liu Xing Bing Xue Za Zhi 2009)
    21. Genetic modulation of ADH1B and ALDH2 polymorphisms with regard to alcohol and tobacco consumption for younger aged esophageal squamous cell carcinoma diagnosis. (PubMed id 19449376)1, 4, 9 Lee C.H....Wu M.T. (Int. J. Cancer 2009)
    22. Carcinogenetic impact of ADH1B and ALDH2 genes on squamous cell carcinoma risk of the esophagus with regard to the consumption of alcohol, tobacco and betel quid. (PubMed id 18033686)1, 4, 9 Lee C.H....Wu M.T. (Int. J. Cancer 2008)
    23. Ethnic differences in level of response to alcohol between Chinese Americans and Korean Americans. (PubMed id 18299763)1, 4, 9 Duranceaux N.C....Wall T.L. (J Stud Alcohol Drugs 2008)
    24. Influence of ALDH2 genetic polymorphisms on aciclovir pharmacokinetics following oral administration of valaciclovir in Japanese end-stage renal disease patients. (PubMed id 18974607)1, 4, 9 Hara K....Nagashima S. (Drug Metab. Pharmacokinet. 2008)
    25. Association of alcohol dehydrogenase 2 and aldehyde dehydrogenase 2 genotypes with fasting plasma glucose levels in Japanese male and female workers. (PubMed id 18216179)1, 4, 9 Dakeishi M....Iwata T. (Alcohol Alcohol. 2008)
    26. Alcohol dehydrogenase-2 and aldehyde dehydrogenase-2 genotypes, alcohol drinking and the risk of primary hepatocellular carcinoma in a Chinese population. (PubMed id 18439068)1, 4, 9 Ding J....Chang J. (Asian Pac. J. Cancer Prev. 2008)
    27. Effects of variation at the ALDH2 locus on alcohol metabolism, sensitivity, consumption, and dependence in Europeans. (PubMed id 16792555)1, 4, 9 Dickson P.A....Birley A.J. (Alcohol. Clin. Exp. Res. 2006)
    28. Gene-environmental interactions between alcohol-drinking behavior and ALDH2 and CYP2E1 polymorphisms and their impact on micronuclei frequency in human lymphocytes. (PubMed id 16126235)1, 4, 9 Ishikawa H....Yokoyama K. (Mutat. Res. 2006)
    29. Relationship between genetic polymorphisms of alcohol and aldehyde dehydrogenases and esophageal squamous cell carcinoma risk in males. (PubMed id 16127737)1, 4, 9 Wu C.F....Wu M.T. (World J. Gastroenterol. 2005)
    30. [Effects of genetic polymorphisms of ethanol-metabolizing enzymes on alcohol drinking behaviors]. (PubMed id 12824748)1, 4, 9 Kee J.Y....Chae H.B. (Taehan Kan Hakhoe Chi 2003)
    31. Multiple cancers associated with esophageal and oropharyngolaryngeal squamous cell carcinoma and the aldehyde dehydrogenase-2 genotype in male Japanese drinkers. (PubMed id 12223435)1, 4, 9 Yokoyama A....Tachimori Y. (amp 2002)
    32. Genetic polymorphisms of alcohol and aldehyde dehydrogenases and glutathione S-transferase M1 and drinking, smoking, and diet in Japanese men with esophageal squamous cell carcinoma. (PubMed id 12419833)1, 4, 9 Yokoyama A....Yoshimizu H. (Carcinogenesis 2002)
    33. ALDH2 genetic polymorphism and the risk of type II diabetes mellitus in CAD patients. (PubMed id 19876063)1, 4, 9 Xu F....Zhang Y. (Hypertens. Res. 2010)
    34. [Relationship between susceptibility of formaldehyde metabolism and genetic polymorphisms of ALDH2 and cytochrome P4502E1]. (PubMed id 19115622)1, 4, 9 Cheng X.M....Shao H. (Zhonghua Yu Fang Yi Xue Za Zhi 2008)
    35. Polymorphisms of alcohol dehydrogenase 2 and aldehyde dehydrogenase 2 and colorectal cancer risk in Chinese males. (PubMed id 18763293)1, 4, 9 Gao C.M....Tajima K. (World J. Gastroenterol. 2008)
    36. Roles of the genetic variation of alcohol-metabolizing enzymes on biomarkers in trauma patients with excessive alcohol intake at emergency department. (PubMed id 18078815)1, 4, 9 Tseng Y.M....Lee J.H. ( international journal of clinical chemistry 2008)
    37. Susceptibility to lung cancer and genetic polymorphisms in the alcohol metabolite-related enzymes alcohol dehydrogenase 3, aldehyde dehydrogenase 2, and cytochrome P450 2E1 in the Japanese population. (PubMed id 17559142)1, 4, 9 Minegishi Y....Esumi H. (Cancer 2007)
    38. Genetic polymorphisms of ADH2 and ALDH2 association with esophageal cancer risk in southwest China. (PubMed id 17963305)1, 4, 9 Yang S.J....Yang C.X. (World J. Gastroenterol. 2007)
    39. Single nucleotide polymorphisms of the ALDH2 gene in six Indian populations. (PubMed id 17952709)1, 4, 9 Bhaskar L.V....Rao V.R. (Ann. Hum. Biol. 2007)
    40. A Glu487Lys polymorphism in the gene for mitochondrial aldehyde dehydrogenase 2 is associated with myocardial infarction in elderly Korean men. (PubMed id 17459359)1, 4, 9 Jo S.A....Jo I. ( international journal of clinical chemistry 2007)
    41. Dietary selenium intake, aldehyde dehydrogenase-2 and X-ray repair cross-complementing 1 genetic polymorphisms, and the risk of esophageal squamous cell carcinoma. (PubMed id 16639733)1, 4, 9 Cai L....Zhang Z.F. (Cancer 2006)
    42. Esophageal cancer risk by ALDH2 and ADH2 polymorphisms and alcohol consumption: exploration of gene-environment and gene-gene interactions. (PubMed id 16235983)1, 4, 9 Yang C.X....Tajima K. (Asian Pac. J. Cancer Prev. 2005)
    43. [Polymorphism of alcohol metabolizing-related enzyme genes and its correlation with drinking-behaviors in 201 cases of Chinese Han healthy population]. (PubMed id 15842823)1, 4, 9 Cao X.R. and Wu D.S. (Zhonghua Yu Fang Yi Xue Za Zhi 2005)
    44. Genetic polymorphisms of aldehyde dehydrogenase 2, cytochrome p450 2E1 for liver cancer risk in HCV antibody-positive japanese patients and the variations of CYP2E1 mRNA expression levels in the liver due to its polymorphism. (PubMed id 12940444)1, 4, 9 Kato S....Naito Z. (Scand. J. Gastroenterol. 2003)
    45. Mean corpuscular volume and the aldehyde dehydrogenase-2 genotype in male Japanese workers. (PubMed id 14506399)1, 4, 9 Yokoyama M....Nakamura H. (Alcohol. Clin. Exp. Res. 2003)
    46. XRCC1, CYP2E1 and ALDH2 genetic polymorphisms and sister chromatid exchange frequency alterations amongst vinyl chloride monomer-exposed polyvinyl chloride workers. (PubMed id 12739102)1, 4, 9 Wong R.H....Cheng T.J. (Arch. Toxicol. 2003)
    47. Effects of ALDH2 gene polymorphisms and alcohol-drinking behavior on micronuclei frequency in non-smokers. (PubMed id 14568296)1, 4, 9 Ishikawa H....Yokoyama K. (Mutat. Res. 2003)
    48. Relationships between cigarette smoking, alcohol drinking, the ALDH2 genotype and adenomatous types of colorectal polyps in male self-defense force officials. (PubMed id 11210104)1, 4, 9 Takeshita T....Kono S. (J Epidemiol 2000)
    49. Alcohol dehydrogenase-2 and aldehyde dehydrogenase-2 genotypes, alcohol drinking and the risk for esophageal cancer in a Chinese population. (PubMed id 20010786)1, 4, 9 Ding J.H....Yao G.H. (J. Hum. Genet. 2010)
    50. A novel polymorphism rs1329149 of CYP2E1 and a known polymorphism rs671 of ALDH2 of alcohol metabolizing enzymes are associated with colorectal cancer in a southwestern Chinese population. (PubMed id 19706845)1, 4, 9 Yang H....Cao J. (amp 2009)
    51. Polymorphisms of alcohol dehydrogenase-2 and aldehyde dehydrogenase-2 and esophageal cancer risk in Southeast Chinese males. (PubMed id 19452585)1, 4, 9 Ding J.H....Yao G.H. (World J. Gastroenterol. 2009)
    52. ALDH2 promoter polymorphism has no effect on the risk for alcoholism. (PubMed id 16624836)1, 4, 9 Kimura M....Higuchi S. (Alcohol Alcohol. 2006)
    53. Influence of alcohol consumption and gene polymorphisms of ADH2 and ALDH2 on hepatocellular carcinoma in a Japanese population. (PubMed id 16187278)1, 4, 9 Sakamoto T....Tanaka K. (Int. J. Cancer 2006)
    54. Mitochondrial aldehyde dehydrogenase-2 (ALDH2) Glu504Lys polymorphism contributes to the variation in efficacy of sublingual nitroglycerin. (PubMed id 16440063)1, 4, 9 Li Y....Jin L. (J. Clin. Invest. 2006)
    55. Effects of dietary intake and genetic factors on hypermethylation of the hMLH1 gene promoter in gastric cancer. (PubMed id 15991278)1, 4, 9 Nan H.M....Kim H. (World J. Gastroenterol. 2005)
    56. Assessment of association between mitochondrial aldehyde dehydrogenase polymorphism and Alzheimer's disease in an older Korean population. (PubMed id 15123334)1, 4, 9 Kim J.M....Yoon J.S. (Neurobiol. Aging 2004)
    57. Do the ethanol metabolizing enzymes modify the relationship between alcohol consumption and blood pressure? (PubMed id 12777946)1, 4, 9 Saito K....Tanaka H. (J. Hypertens. 2003)
    58. Protective association of genetic variation in alcohol dehydrogenase with alcohol dependence in Native American Mission Indians. (PubMed id 12505800)1, 4, 9 Wall T.L....Ehlers C.L. (Am J Psychiatry 2003)
    59. An investigation of associations between alcohol use disorder and polymorphisms on ALDH2, BDNF, 5-HTTLPR, and MTHFR genes in older Korean men. (PubMed id 19637400)1, 4, 9 Shin S....Yoon J.S. (Int J Geriatr Psychiatry 2010)
    60. Alcohol dehydrogenase 1B and Aldehyde dehydrogenase 2 Polymorphisms in Uzbekistan. (PubMed id 19469618)1, 4, 9 Ahn K.S....Hamajima N. (Asian Pac. J. Cancer Prev. 2009)
    61. SPINK1, ADH2, and ALDH2 gene variants and alcoholic chronic pancreatitis in Japan. (PubMed id 18336671)1, 4, 9 Shimosegawa T....Masamune A. (J. Gastroenterol. Hepatol. 2008)
    62. Evidence for involvement of calcitonin gene-related peptide in nitroglycerin response and association with mitochondrial aldehyde dehydrogenase-2 (ALDH2) Glu504Lys polymorphism. (PubMed id 18772068)1, 4, 9 Guo R....Li Y.J. (J. Am. Coll. Cardiol. 2008)
    63. The effect of genetic polymorphisms in the vinyl chloride metabolic pathway on mutagenic risk. (PubMed id 17384900)1, 4, 9 Schindler J....Brandt-Rauf P.W. (J. Hum. Genet. 2007)
    64. Diplotype trend regression analysis of the ADH gene cluster and the ALDH2 gene: multiple significant associations with alcohol dependence. (PubMed id 16685648)1, 4, 9 Luo X....Gelernter J. (Am. J. Hum. Genet. 2006)
    65. Meta-analyses of ALDH2 and ADH1B with alcohol dependence in Asians. (PubMed id 16822169)1, 4, 9 Luczak S.E....Wall T.L. (Psychol Bull 2006)
    66. Associations of ALDH2 and ADH1B genotypes with response to alcohol in Asian Americans. (PubMed id 15957670)1, 4, 9 Cook T.A....Wall T.L. (J. Stud. Alcohol 2005)
    67. Mitochondrial aldehyde dehydrogenase polymorphism is not associated with incidence of Alzheimer's disease. (PubMed id 16250071)1, 4, 9 Shin I.S....Yoon J.S. (Int J Geriatr Psychiatry 2005)
    68. Alcohol and aldehyde dehydrogenase polymorphisms in men with type I and Type II alcoholism. (PubMed id 15863807)1, 4, 9 Chai Y.G....Choi I.G. (Am J Psychiatry 2005)
    69. Association of aldehyde dehydrogenase-2 polymorphism with alcoholic polyneuropathy in humans. (PubMed id 15182962)1, 4, 9 Masaki T....Higuchi S. (Neurosci. Lett. 2004)
    70. Role of alcohol and genetic polymorphisms of CYP2E1 and ALDH2 in breast cancer development. (PubMed id 12563175)1, 4, 9 Choi J.Y....Kang D. (Pharmacogenetics 2003)
    71. Alcohol dehydrogenase-2 and aldehyde dehydrogenase-2 genotypes and male alcohol use disorders in Khon Kaen, north-east Thailand. (PubMed id 12519453)1, 4, 9 Osaka R....Fukuda K. (Psychiatry Clin. Neurosci. 2003)
    72. Polymorphisms for vinyl chloride metabolism in French vinyl chloride workers. (PubMed id 12705718)1, 4, 9 Li Y....Brandt-Rauf P.W. (Int J Occup Med Environ Health 2003)
    73. A case-control study of association between life-style, alcohol dehydrogenase 2 and aldehyde dehydrogenase 2 genotype and idiopathic osteonecrosis of the femoral head. (PubMed id 14768474)1, 4, 9 Sakata R. (Kurume Med J 2003)
    74. Genotype of ethanol metabolizing enzyme genes by oligonucleotide microarray in alcoholic liver disease in Chinese people. (PubMed id 12173598)1, 4, 9 Yu C....Yue M. (Chin. Med. J. 2002)
    75. [Compare of distributions of gene polymorphisms about alcohol metabolizing-related enzymes in five Chinese nationalities]. (PubMed id 12545748)1, 4, 9 Cao X. and Wu D. (Wei Sheng Yan Jiu 2002)
    76. Chinese alcoholic patients with esophageal cancer are genetically different from alcoholics with acute pancreatitis and liver cirrhosis. (PubMed id 11051375)1, 4, 9 Chao Y.C....Chu H.C. (Am. J. Gastroenterol. 2000)
    77. Alcohol and aldehyde dehydrogenase polymorphisms in Japanese patients with alcohol-induced chronic pancreatitis. (PubMed id 11117576)1, 4, 9 Kimura S....Kasuga M. (Dig. Dis. Sci. 2000)
    78. Genetic determinants of both ethanol and acetaldehyde metabolism influence alcohol hypersensitivity and drinking behaviour among Scandinavians. (PubMed id 20205700)1, 4, 9 Linneberg A....Husemoen L.L. (Clin. Exp. Allergy 2010)
    79. The polymorphism in aldehyde dehydrogenase-2 gene is associated with elevated plasma levels of high-sensitivity C-reactive protein in the early phase of myocardial infarction. (PubMed id 20467232)1, 4, 9 Bian Y....Zhang Y. (Tohoku J. Exp. Med. 2010)
    80. Alcohol and aldehyde dehydrogenase polymorphisms in Chinese and Indian populations. (PubMed id 20025435)1, 4, 9 Tan E.C....Winslow M. (amp 2010)
    81. Association of ALDH2 genotypes with periodontitis progression. (PubMed id 20042735)1, 4, 9 Nishida N....Shizukuishi S. (J. Dent. Res. 2010)
    82. Origin and dispersal of atypical aldehyde dehydrogenase ALDH2487Lys. (PubMed id 19393179)1, 4, 9 Luo H.R....Zhang Y.P. (Gene 2009)
    83. Association of ADH1B and ALDH2 gene polymorphisms with alcohol dependence: a pilot study from India. (PubMed id 19403456)1, 4, 9 Vaswani M....Kapur S. (Hum. Genomics 2009)
    84. Comparison of genetic polymorphisms of CYP2E1, ADH2, and ALDH2 genes involved in alcohol metabolism in Koreans and four other ethnic groups. (PubMed id 19250143)1, 4, 9 Kang T.S....Roh J. (J Clin Pharm Ther 2009)
    85. Impact of multiple alcohol dehydrogenase gene polymorphisms on risk of upper aerodigestive tract cancers in a Japanese population. (PubMed id 19861527)1, 4, 9 Oze I....Tanaka H. (amp 2009)
    86. Interaction of the effects of alcohol drinking and polymorphisms in alcohol-metabolizing enzymes on the risk of female breast cancer in Japan. (PubMed id 19667493)1, 4, 9 Kawase T....Tajima K. (J Epidemiol 2009)
    87. Aldehyde dehydrogenase 2 and head and neck cancer: a meta-analysis implementing a Mendelian randomization approach. (PubMed id 19124505)1, 4, 9 Boccia S....Boffetta P. (amp 2009)
    88. Pharmacokinetic and pharmacodynamic basis for overcoming acetaldehyde-induced adverse reaction in Asian alcoholics, heterozygous for the variant ALDH2*2 gene allele. (PubMed id 19584771)1, 4, 9 Chen Y.C....Yin S.J. (Pharmacogenet. Genomics 2009)
    89. Gender differences in the genetic risk for alcohol dependence--the results of a pharmacogenetic study in Korean alcoholics. (PubMed id 20077761)1, 4, 9 Kim S.G. (amp 2009)
    90. Genetic polymorphisms of alcohol metabolising enzymes: their role in susceptibility to oesophageal cancer. (PubMed id 18254707)1, 4, 9 Li D.P....Parker M.I. (Clin. Chem. Lab. Med. 2008)
    91. Microsatellite scan identifies new candidate genes for susceptibility to alcoholic chronic pancreatitis in Japanese patients. (PubMed id 19096130)1, 4, 9 Kitahara K....Ota M. (Dis. Markers 2008)
    92. [Correlation analyses of ALDH2 and CYP2E1 genetic polymorphism with personality]. (PubMed id 19230487)1, 4, 9 Ohtsuka Y....Iwahashi K. (amp 2008)
    93. Alcohol-metabolizing enzyme gene polymorphisms and alcohol chronic pancreatitis among Polish individuals. (PubMed id 18773092)1, 4, 9 Cichoz-Lach H....SA8omka M. (HPB (Oxford) 2008)
    94. Association of ADH and ALDH genes with alcohol dependence in the Irish Affected Sib Pair Study of alcohol dependence (IASPSAD) sample. (PubMed id 18331377)1, 4, 9 Kuo P.H....Riley B.P. (Alcohol. Clin. Exp. Res. 2008)
    95. Risk of metachronous squamous cell carcinoma in the upper aerodigestive tract of Japanese alcoholic men with esophageal squamous cell carcinoma: a long-term endoscopic follow-up study. (PubMed id 18429959)1, 4, 9 Yokoyama A....Maruyama K. (Cancer Sci. 2008)
    96. The association of mitochondrial aldehyde dehydrogenase gene (ALDH2) polymorphism with susceptibility to late-onset Alzheimer's disease in Chinese. (PubMed id 18201725)1, 4, 9 Wang B....Ma X. (J. Neurol. Sci. 2008)
    97. Common single nucleotide polymorphisms in Japanese patients with essential hypertension: aldehyde dehydrogenase 2 gene as a risk factor independent of alcohol consumption. (PubMed id 17785925)1, 4, 9 Hui P....Cheng Z. (Hypertens. Res. 2007)
    98. Genetic polymorphisms in alcohol metabolism, alcohol intake and the risk of stomach cancer in Warsaw, Poland. (PubMed id 17631643)1, 4, 9 Zhang F.F....Chow W.H. (Int. J. Cancer 2007)
    99. Genetic polymorphisms of alcohol and aldehyde dehydrogenases, and drinking, smoking and diet in Japanese men with oral and pharyngeal squamous cell carcinoma. (PubMed id 17071628)1, 4, 9 Asakage T....Watanabe H. (Carcinogenesis 2007)
    100. p53 Protein accumulation, cancer multiplicity, and aldehyde dehydrogenase-2 genotype in Japanese alcoholic men with early esophageal squamous cell carcinoma. (PubMed id 16759795)1, 4, 9 Yokoyama A....Hibi T. (Cancer Lett. 2007)
    101. Alcohol dehydrogenase and aldehyde dehydrogenase polymorphisms and colorectal cancer: the Fukuoka Colorectal Cancer Study. (PubMed id 17517051)1, 4, 9 Yin G....Imaizumi N. (Cancer Sci. 2007)
    102. Alcohol dehydrogenase and aldehyde dehydrogenase gene polymorphism in alcohol liver cirrhosis and alcohol chronic pancreatitis among Polish individuals. (PubMed id 17454860)1, 4, 9 Cichoz-Lach H....Wojcierowski J. (Scand. J. Gastroenterol. 2007)
    103. Impact of the alcohol-dehydrogenase (ADH) 1C and ADH1B polymorphisms on drinking behavior in nonalcoholic Japanese. (PubMed id 17285601)1, 4, 9 Matsuo K....Tajima K. (Hum. Mutat. 2007)
    104. Effect of the CYP2E1 genotype on vinyl chloride monomer-induced liver fibrosis among polyvinyl chloride workers. (PubMed id 17659824)1, 4, 9 Hsieh H.I....Cheng T.J. (Toxicology 2007)
    105. The polymorphism in acetaldehyde dehydrogenase 2 gene, causing a substitution of Glu &gt; Lys(504), is not associated with coronary atherosclerosis severity in Han Chinese. (PubMed id 17984618)1, 4, 9 Xu F....Zhang Y. (Tohoku J. Exp. Med. 2007)
    106. Contribution of the alcohol dehydrogenase-1B genotype and oral microorganisms to high salivary acetaldehyde concentrations in Japanese alcoholic men. (PubMed id 17471563)1, 4, 9 Yokoyama A....Yokoyama T. (Int. J. Cancer 2007)
    107. Association of mu-opioid receptor gene polymorphism A118G with alcohol dependence in a Japanese population. (PubMed id 16679777)1, 4, 9 Nishizawa D....Ikeda K. (Neuropsychobiology 2006)
    108. A gene-gene interaction between ALDH2 Glu487Lys and ADH2 His47Arg polymorphisms regarding the risk of colorectal cancer in Japan. (PubMed id 16332725)1, 4, 9 Matsuo K....Tajima K. (Carcinogenesis 2006)
    109. Genetic polymorphisms of alcohol and aldehyde dehydrogenase, dopamine and serotonin transporters in familial and non-familial alcoholism. (PubMed id 16125912)1, 4, 9 Choi I.G....Shin H.D. (Eur Neuropsychopharmacol 2006)
    110. ALDH2 1510 G/A (Glu487Lys) polymorphism interaction with age in head and neck squamous cell carcinoma. (PubMed id 17033202)1, 4, 9 Hashimoto T....Hinoda Y. (Tumour Biol. 2006)
    111. Clinical and genetic characteristics of Korean male alcoholics with and without attention deficit hyperactivity disorder. (PubMed id 16679343)1, 4, 9 Kim J.W....Kim B.N. (Alcohol Alcohol. 2006)
    112. Alcohol dehydrogenase 2 His47Arg polymorphism influences drinking habit independently of aldehyde dehydrogenase 2 Glu487Lys polymorphism: analysis of 2,299 Japanese subjects. (PubMed id 16702384)1, 4, 9 Matsuo K....Tajima K. (amp 2006)
    113. SPINK1 gene mutations and pancreatitis in Japan. (PubMed id 16958672)1, 4, 9 Shimosegawa T....Masamune A. (J. Gastroenterol. Hepatol. 2006)
    114. [Genetic susceptibility to the development of acute alcoholic hepatitis: role of genetic mutations in dehydrogenase alcohol, aldehyde dehydrogenase and cytochrome P450 2E1]. (PubMed id 16324524)1, 4, 9 Segado Soriano A....GA^mez-Gallego F. (Rev Clin Esp 2005)
    115. Genetic polymorphisms of methylenetetrahydrofolate reductase and aldehyde dehydrogenase 2, alcohol use and risk of colorectal adenomas: Self-Defense Forces Health Study. (PubMed id 16108833)1, 4, 9 Hirose M....Ikeda N. (Cancer Sci. 2005)
    116. Change of components of the metabolic syndrome in a workers' health checkup after five years--relation with elevated liver enzymes, gene polymorphisms for ALDH 2, beta3-AR and lifestyle. (PubMed id 16408483)1, 4, 9 Ishikawa N....Watanabe T. (Nihon Koshu Eisei Zasshi 2005)
    117. Relation of the CD36 gene A52C polymorphism to the risk of colorectal cancer among Japanese, with reference to with the aldehyde dehydrogenase 2 gene Glu487Lys polymorphism and drinking habit. (PubMed id 15780035)1, 4, 9 Kuriki K....Tajima K. (Asian Pac. J. Cancer Prev. 2005)
    118. [Alcohol-induced arterial hypertension and genetic polymorphism of alcohol-metabolizing enzymes]. (PubMed id 16078602)1, 4, 9 Moiseev V.S....Shipulin G.A. (Ter. Arkh. 2005)
    119. Association of habitual smoking and drinking with single nucleotide polymorphism (SNP) in 40 candidate genes: data from random population-based Japanese samples. (PubMed id 15654505)1, 4, 9 Liu Y....Tsugane S. (J. Hum. Genet. 2005)
    120. A comprehensive analysis of phase I and phase II metabolism gene polymorphisms and risk of colorectal cancer. (PubMed id 16006997)1, 4, 9 Landi S....Canzian F. (Pharmacogenet. Genomics 2005)
    121. Esophageal melanosis, an endoscopic finding associated with squamous cell neoplasms of the upper aerodigestive tract, and inactive aldehyde dehydrogenase-2 in alcoholic Japanese men. (PubMed id 16082583)1, 4, 9 Yokoyama A....Hibi T. (J. Gastroenterol. 2005)
    122. [Genetic polymorphisms of alcohol-metabolizing enzymes and cytokines in patients with alcohol induced pancreatitis and alcoholic liver cirrhosis]. (PubMed id 15220553)1, 4, 9 Kim M.S....Lee M.S. (Korean J Gastroenterol 2004)
    123. Influence of genetic variations of ethanol-metabolizing enzymes on phenotypes of alcohol-related disorders. (PubMed id 15542751)1, 4, 9 Higuchi S....Mochizuki H. (Ann. N. Y. Acad. Sci. 2004)
    124. ADH1B*1, ADH1C*2, DRD2 (-141C Ins), and 5-HTTLPR are associated with alcoholism in Mexican American men living in Los Angeles. (PubMed id 15318112)1, 4, 9 Konishi T....Wan Y.J. (Alcohol. Clin. Exp. Res. 2004)
    125. Possible interaction of alcohol dehydrogenase and aldehyde dehydrogenase genes with the dopamine D2 receptor gene in anxiety-depressive alcohol dependence. (PubMed id 15084894)1, 4, 9 Huang S.Y....Lu R.B. (Alcohol. Clin. Exp. Res. 2004)
    126. Genotype announcement in a genetic polymorphism study for health checkup examinees at Nagoya University Hospital. (PubMed id 15279067)1, 4, 9 Nishio K....Hamajima N. (Nagoya J Med Sci 2004)
    127. Genetic polymorphisms of tobacco- and alcohol-related metabolizing enzymes and the risk of hepatocellular carcinoma. (PubMed id 12759747)1, 4, 9 Munaka M....Katoh T. (J. Cancer Res. Clin. Oncol. 2003)
    128. [Gene-environmental interactions in alcohol-related health problems--contributions of molecular biology to behavior modifications]. (PubMed id 12806963)1, 4, 9 Takeshita T. (Nihon Eiseigaku Zasshi 2003)
    129. Investigation of alcohol metabolizing enzyme genes in Chinese alcoholics with avascular necrosis of hip joint, pancreatitis and cirrhosis of the liver. (PubMed id 12915519)1, 4, 9 Chao Y.C....Hsieh T.Y. (Alcohol Alcohol. 2003)
    130. Allele frequencies of single nucleotide polymorphisms (SNPs) in 40 candidate genes for gene-environment studies on cancer: data from population-based Japanese random samples. (PubMed id 14634838)1, 4, 9 Yoshimura K....Tsugane S. (J. Hum. Genet. 2003)
    131. Effects of aldehyde dehydrogenase genotypes on carotid atherosclerosis. (PubMed id 14597338)1, 4, 9 Narita M....Hori M. (amp 2003)
    132. [Studies of genetic polymorphisms of ADH2 and ALDH2 among the Han population in Luoyang China]. (PubMed id 16135443)1, 4, 9 Zhang Z.M....Shen F.M. (Yi Chuan 2002)
    133. Alcohol sensitivity in Taiwanese men with different alcohol and aldehyde dehydrogenase genotypes. (PubMed id 12517056)1, 4, 9 Peng G.S....Yin S.J. (J. Formos. Med. Assoc. 2002)
    134. Association between aldehyde dehydrogenase gene polymorphisms and the phenomenon of field cancerization in patients with head and neck cancer. (PubMed id 12376487)1, 4, 9 Muto M....Esumi H. (Carcinogenesis 2002)
    135. Polymorphism in alcohol-metabolizing enzymes, glutathione S-transferases and apolipoprotein E and susceptibility to alcohol-induced cirrhosis and chronic pancreatitis. (PubMed id 11966948)1, 4, 9 Frenzer A....Roberts-Thomson I.C. (J. Gastroenterol. Hepatol. 2002)
    136. The genetics of alcoholism in Polynesians: alcohol and aldehyde dehydrogenase genotypes in young men. (PubMed id 12170102)1, 4, 9 Chambers G.K....Chong N.L. (Alcohol. Clin. Exp. Res. 2002)
    137. Aldehyde dehydrogenase 2 gene is a risk factor for myocardial infarction in Japanese men. (PubMed id 12452318)1, 4, 9 Takagi S....Goto Y. (Hypertens. Res. 2002)
    138. Epidemiologic study of the association of low-Km mitochondrial acetaldehyde dehydrogenase genotypes with blood pressure level and the prevalence of hypertension in a general population. (PubMed id 12484509)1, 4, 9 Amamoto K....Ueshima H. (Hypertens. Res. 2002)
    139. Genotype frequencies of 50 polymorphisms for 241 Japanese non-cancer patients. (PubMed id 12164325)1, 4, 9 Hamajima N....Tajima K. (J Epidemiol 2002)
    140. Association between polymorphisms of ethanol-metabolizing enzymes and susceptibility to alcoholic cirrhosis in a Korean male population. (PubMed id 11748356)1, 4, 9 Lee H.C....Kim C.Y. (J. Korean Med. Sci. 2001)
    141. Association of polymorphism in the alcohol dehydrogenase 2 gene with alcohol-induced testicular atrophy. (PubMed id 11410735)1, 4, 9 Yamauchi M....Toda G. (Alcohol. Clin. Exp. Res. 2001)
    142. Molecular epidemiology of preterm delivery: methodology and challenges. (PubMed id 11520401)1, 4, 9 Wang X....Xu X. (Paediatr Perinat Epidemiol 2001)
    143. Alcoholism, ALDH2*2 allele and the A1 allele of the dopamine D2 receptor gene: an association study. (PubMed id 11600186)1, 4, 9 Matsushita S....Higuchi S. (Psychiatry Res 2001)
    144. Testing genetic susceptibility loci for alcoholic heart muscle disease. (PubMed id 11696658)1, 4, 9 Kajander O.A....Karhunen P.J. (Alcohol. Clin. Exp. Res. 2001)
    145. Screening for acetaldehyde dehydrogenase 2 genotype in alcohol-induced asthma by using the ethanol patch test. (PubMed id 11692094)1, 4, 9 Matsuse H....Kohno S. (J. Allergy Clin. Immunol. 2001)
    146. Association of the ADH2 genotypes with skin responses after ethanol exposure in Japanese male university students. (PubMed id 11584144)1, 4, 9 Takeshita T....Morimoto K. (Alcohol. Clin. Exp. Res. 2001)
    147. Alcohol and aldehyde dehydrogenase gene polymorphisms and oropharyngolaryngeal, esophageal and stomach cancers in Japanese alcoholics. (PubMed id 11238183)1, 4, 9 Yokoyama A....Ishii H. (Carcinogenesis 2001)
    148. Binge drinking in Chinese, Korean, and White college students: genetic and ethnic group differences. (PubMed id 11767261)1, 4, 9 Luczak S.E....Carr L.G. (Psychol Addict Behav 2001)
    149. Genome-wide association study for intracranial aneurysm in the Japanese population identifies three candidate susceptible loci and a functional genetic variant at EDNRA. (PubMed id 22286173)1, 4 Low S.K....Nakamura Y. (Hum. Mol. Genet. 2012)
    150. A genome-wide association and gene-environment interaction study for serum triglycerides levels in a healthy Chinese male population. (PubMed id 22171074)1, 4 Tan A....Xu J. (Hum. Mol. Genet. 2012)
    151. Genome-wide association study of coronary artery disease in the Japanese. (PubMed id 21971053)1, 4 Takeuchi F....Kato N. (Eur. J. Hum. Genet. 2012)
    152. Confirmation of ALDH2 as a Major locus of drinking behavior and of its variants regulating multiple metabolic phenotypes in a Japanese population. (PubMed id 21372407)1, 4 Takeuchi F....Kato N. (Circ. J. 2011)
    153. A genome-wide association study of hypertension-related phenotypes in a Japanese population. (PubMed id 20877124)1, 4 Hiura Y....Iwai N. (Circ. J. 2010)
    154. Genetic polymorphisms in folate and alcohol metabolism and breast cancer risk: a case-control study in Thai women. (PubMed id 20180013)1, 4 Sangrajrang S....Yoshida T. (Breast Cancer Res. Treat. 2010)
    155. Strong interaction between the effects of alcohol consumption and smoking on oesophageal squamous cell carcinoma among individuals with ADH1B and/or ALDH2 risk alleles. (PubMed id 20833657)1, 4 Tanaka F....Mori M. (Gut 2010)
    156. Alcohol and aldehyde dehydrogenase polymorphisms and risk for suicide: a preliminary observation in the Japanese male population. (PubMed id 20180859)1, 4 Hishimoto A....Shirakawa O. (Genes Brain Behav. 2010)
    157. The ALDH2 Glu504Lys polymorphism is associated with coronary artery disease in Han Chinese: Relation with endothelial ADMA levels. (PubMed id 20417517)1, 4 Guo Y.J....Chen X.P. (Atherosclerosis 2010)
    158. Impact of smoking on lung cancer risk is stronger in those with the homozygous aldehyde dehydrogenase 2 null allele in a Japanese population. (PubMed id 20093384)1, 4 Park J.Y....Tanaka H. (Carcinogenesis 2010)
    159. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    160. Genome-wide association study of hematological and biochemical traits in a Japanese population. (PubMed id 20139978)1, 4 Kamatani Y....Kamatani N. (Nat. Genet. 2010)
    161. Prevalence and persistence of chromosomal damage and susceptible genotypes of metabolic and DNA repair genes in Chinese vinyl chloride-exposed workers. (PubMed id 20100738)1, 4 Ji F....Christiani D.C. (Carcinogenesis 2010)
    162. Relationship between genetic polymorphisms of ALDH2 and ADH1B and esophageal cancer risk: a meta-analysis. (PubMed id 20806441)1, 4 Yang S.J....Yang C.X. (World J. Gastroenterol. 2010)
    163. Association of aldehyde dehydrogenase 2 gene polymorphism with pancreatic cancer but not colon cancer. (PubMed id 20590827)1, 4 Miyasaka K....Funakoshi A. (amp 2010)
    164. Genetic susceptibility to distinct bladder cancer subphenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (Eur. Urol. 2010)
    165. Interaction among genes influencing ethanol metabolism and sex is association with alcohol use disorders in a Tibet population. (PubMed id 19655364)1, 4 Guo W....Hu X. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    166. Alcohol, tobacco and genetic susceptibility in relation to cancers of the upper aerodigestive tract in northern Italy. (PubMed id 20437850)1, 4 Canova C....Simonato L. (Tumori 2010)
    167. Effects of alcohol-drinking behaviour and ADH1B and ALDH2 polymorphisms on basal DNA damage in human mononuclear cells as determined by the comet assay. (PubMed id 20685249)1, 4 Weng H....Morimoto K. (Mutat. Res. 2010)
    168. The association of alcohol and alcohol metabolizing gene variants with diabetes and coronary heart disease risk factors in a white population. (PubMed id 20700531)1, 4 Husemoen L.L....Linneberg A. (PLoS ONE 2010)
    169. Polymorphisms of alcohol metabolizing enzymes in indigenous Mexican population: unusual high frequency of CYP2E1*c2 allele. (PubMed id 19860798)1, 4 Gordillo-Bastidas E....Bastidas-RamA-rez B.E. (Alcohol. Clin. Exp. Res. 2010)
    170. Evaluation of a brief web-based genetic feedback intervention for reducing alcohol-related health risks associated with ALDH2. (PubMed id 20652463)1, 4 Hendershot C.S....Wall T.L. (Ann Behav Med 2010)
    171. Association of genetic polymorphisms of aldehyde dehydrogenase-2 with esophageal squamous cell dysplasia. (PubMed id 20632450)1, 4 Zhou Y.Z....Cui J. (World J. Gastroenterol. 2010)
    172. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    173. Meta-analysis of ADH1B and ALDH2 polymorphisms and esophageal cancer risk in China. (PubMed id 21157980)1, 4 Zhang G.H....Huang B. (World J. Gastroenterol. 2010)
    174. Association between aldehyde dehydrogenase 2 genetic polymorphism and serum lipids or lipoproteins: a meta-analysis of seven East Asian populations. (PubMed id 20541757)1, 4 Hao P.P....Zhang Y. (Atherosclerosis 2010)
    175. Comparison between self-reported facial flushing after alcohol consumption and ALDH2 Glu504Lys polymorphism for risk of upper aerodigestive tract cancer in a Japanese population. (PubMed id 20518787)1, 4 Oze I....Tanaka H. (Cancer Sci. 2010)
    176. Gene-environmental interaction regarding alcohol-metabolizing enzymes in the Japanese general population. (PubMed id 19262484)1, 4 Tsuchihashi-Makaya M....Kato N. (Hypertens. Res. 2009)
    177. Determination of genetic predisposition to patent ductus arteriosus in preterm infants. (PubMed id 19336370)1, 4 Dagle J.M....Murray J.C. (Pediatrics 2009)
    178. Integrative predictive model of coronary artery calcification in atherosclerosis. (PubMed id 19948975)1, 4 McGeachie M....Ramoni M.F. (Circulation 2009)
    179. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PubMed id 19343046)1, 4 Saito A....Kamatani N. (J. Hum. Genet. 2009)
    180. ALDH2, ADH1B and alcohol expectancies: integrating genetic and learning perspectives. (PubMed id 19769429)1, 4 Hendershot C.S....Larimer M.E. (Psychol Addict Behav 2009)
    181. Genetic associations of 115 polymorphisms with cancers of the upper aerodigestive tract across 10 European countries: the ARCAGE project. (PubMed id 19339270)1, 4 Canova C....Brennan P. (Cancer Res. 2009)
    182. Effects of polymorphisms in untranslated regions of the class I alcohol dehydrogenase (ADH) genes on alcohol metabolism in Japanese subjects and transcriptional activity in HepG2 cells. (PubMed id 19618839)1, 4 Nishimura F.T....Saijoh K. (amp 2009)
    183. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PubMed id 19170196)1, 4 Shen M....Lan Q. (Environ. Mol. Mutagen. 2009)
    184. Genetical genomic determinants of alcohol consumption in rats and humans. (PubMed id 19874574)1, 4 Tabakoff B....Hoffman P.L. (BMC Biol. 2009)
    185. Refined geographic distribution of the oriental ALDH2*504Lys (nee 487Lys) variant. (PubMed id 19456322)1, 4 Li H....Kidd K.K. (Ann. Hum. Genet. 2009)
    186. Is habitual alcohol drinking associated with reduced electrophoretic DNA migration in peripheral blood leukocytes from ALDH2-deficient male Japanese? (PubMed id 19286920)1, 4 Lu Y. and Morimoto K. (Mutagenesis 2009)
    187. Impact of alcohol consumption with polymorphisms in alcohol-metabolizing enzymes on pancreatic cancer risk in Japanese. (PubMed id 19068087)1, 4 Kanda J....Tanaka H. (Cancer Sci. 2009)
    188. PTEN identified as important risk factor of chronic obstructive pulmonary disease. (PubMed id 19625176)1, 4 Hosgood H.D....Lan Q. (Respir Med 2009)
    189. Polymorphisms in the promoter region of the human class II alcohol dehydrogenase (ADH4) gene affect both transcriptional activity and ethanol metabolism in Japanese subjects. (PubMed id 19182438)1, 4 Kimura Y....Saijoh K. (J Toxicol Sci 2009)
    190. Candidate gene association study of esophageal squamous cell carcinoma in a high-risk region in Iran. (PubMed id 19826048)1, 4 Akbari M.R....Narod S.A. (Cancer Res. 2009)
    191. Genetic contributions to the development of retinopathy of prematurity. (PubMed id 18787502)1, 4 Mohamed S....Dagle J.M. (Pediatr. Res. 2009)
    192. Functional variants in ADH1B and ALDH2 coupled with alcohol and smoking synergistically enhance esophageal cancer risk. (PubMed id 19698717)1, 4 Cui R....Matsuda K. (Gastroenterology 2009)
    193. Associations of ADH and ALDH2 gene variation with self report alcohol reactions, consumption and dependence: an integrated analysis. (PubMed id 18996923)1, 4 Macgregor S....Whitfield J.B. (Hum. Mol. Genet. 2009)
    194. Risk of malignant pleural mesothelioma and polymorphisms in genes involved in the genome stability and xenobiotics metabolism. (PubMed id 19751749)1, 4 Gemignani F....Landi S. (Mutat. Res. 2009)
    195. Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. (PubMed id 18676680)1, 4 Hosgood H.D....Lan Q. (Carcinogenesis 2008)
    196. Effects of functional polymorphisms related to catecholaminergic systems on changes in blood catecholamine and cardiovascular measures after alcohol ingestion in the Japanese population. (PubMed id 18715275)1, 4 Nishimura F.T....Saijoh K. (Alcohol. Clin. Exp. Res. 2008)
    197. The association between DRD2/ANKK1, 5-HTTLPR gene, and specific personality trait on antisocial alcoholism among Han Chinese in Taiwan. (PubMed id 17948892)1, 4 Wu C.Y....Lu R.B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008)
    198. Polymorphisms in mitochondrial genes and prostate cancer risk. (PubMed id 19064571)1, 4 Wang L....Thibodeau S.N. (amp 2008)
    199. Screening of 214 single nucleotide polymorphisms in 44 candidate cancer susceptibility genes: a case-control study on gastric and colorectal cancers in the Japanese population. (PubMed id 18510611)1, 4 Ikeda S....Tsugane S. (Am. J. Gastroenterol. 2008)
    200. Prevalence and risk factors of atrophic gastritis and intestinal metaplasia in a Korean population without significant gastroduodenal disease. (PubMed id 18665932)1, 4 Kim N....Song I.S. (Helicobacter 2008)
    201. Major genetic components underlying alcoholism in Korean population. (PubMed id 18056758)1, 4 Kim D.J....Shin H.D. (Hum. Mol. Genet. 2008)
    202. Sex differences in environmental and genetic factors for hypertension. (PubMed id 18724972)1, 4 Ruixing Y....Yuming C. (Am. J. Med. 2008)
    203. A comprehensive analysis of phase I and phase II metabolism gene polymorphisms and risk of non-small cell lung cancer in smokers. (PubMed id 18258609)1, 4 Zienolddiny S....Haugen A. (Carcinogenesis 2008)
    204. Alcohol intake and blood pressure: a systematic review implementing a Mendelian randomization approach. (PubMed id 18318597)1, 4 Chen L....Lewis S.J. (PLoS Med. 2008)
    205. Pharmacokinetic and pharmacodynamic basis for partial protection against alcoholism in Asians, heterozygous for the variant ALDH2*2 gene allele. (PubMed id 17885622)1, 4 Peng G.S....Yin S.J. (Pharmacogenet. Genomics 2007)
    206. A polymorphism of the aldehyde dehydrogenase 2 gene is a risk factor for multiple lacunar infarcts in Japanese men: the Takahata Study. (PubMed id 17388993)1, 4 Nagasawa H....Kato T. (Eur. J. Neurol. 2007)
    207. Gene-gene and gene-environment interactions between alcohol drinking habit and polymorphisms in alcohol-metabolizing enzyme genes and the risk of head and neck cancer in Japan. (PubMed id 17489985)1, 4 Hiraki A....Tajima K. (Cancer Sci. 2007)
    208. Association analysis of the dopamine receptor D2 (DRD2) SNP rs1076560 in alcoholic patients. (PubMed id 17196743)1, 4 Sasabe T....Ishiura S. (Neurosci. Lett. 2007)
    209. ALDH2 polymorphisms and bone mineral density in an elderly Japanese population. (PubMed id 16520888)1, 4 Yamaguchi J....Hamajima N. (Osteoporos Int 2006)
    210. Do alcohol-metabolizing enzyme gene polymorphisms increase the risk of alcoholism and alcoholic liver disease? (PubMed id 16440362)1, 4 Zintzaras E....Vidal F. (Hepatology 2006)
    211. Association of alcohol-metabolizing genes with alcoholism in a Mexican Indian (Otomi) population. (PubMed id 17134659)1, 4 Montano Loza A.J....Gutierrez Reyes G. (Alcohol 2006)
    212. Association of V227A PPARalpha polymorphism with altered serum biochemistry and alcohol drinking in Japanese men. (PubMed id 16847426)1, 4 Naito H....Nakajima T. (Pharmacogenet. Genomics 2006)
    213. Polymorphisms of alcohol-metabolizing enzymes and the risk for alcoholism and alcoholic liver disease in Caucasian Spanish women. (PubMed id 16600530)1, 4 Lorenzo A....Richart C. (Drug Alcohol Depend 2006)
    214. [Polymorphisms of aldehyde and alcohol dehydrogenase genes associated with susceptibility to trichloroethylene-induced medicamentosa-like dermatitis]. (PubMed id 16758956)1, 4 Li H.S....Sun Y.F. (Wei Sheng Yan Jiu 2006)
    215. ALDH2*2 is associated with a decreased likelihood of alcohol-induced blackouts in Asian American college students. (PubMed id 16608143)1, 4 Luczak S.E....Wall T.L. (J. Stud. Alcohol 2006)
    216. Psychosocial, cultural and genetic influences on alcohol use in Asian American youth. (PubMed id 15957669)1, 4 Hendershot C.S....Wall T.L. (J. Stud. Alcohol 2005)
    217. Alcohol, ALDH2, and esophageal cancer: a meta-analysis which illustrates the potentials and limitations of a Mendelian randomization approach. (PubMed id 16103445)1, 4 Lewis S.J. and Smith G.D. (amp 2005)
    218. Hangover susceptibility in relation to aldehyde dehydrogenase-2 genotype, alcohol flushing, and mean corpuscular volume in Japanese workers. (PubMed id 16046871)1, 4 Yokoyama M....Nakamura H. (Alcohol. Clin. Exp. Res. 2005)
    219. Folate, vitamin B6, vitamin B12, and vitamin B2 intake, genetic polymorphisms of related enzymes, and risk of colorectal cancer in a hospital-based case-control study in Japan. (PubMed id 16351505)1, 4 Otani T....Tsugane S. (Nutr Cancer 2005)
    220. No alcoholism-protection effects of ADH1B*2 allele in antisocial alcoholics among Han Chinese in Taiwan. (PubMed id 16385179)1, 4 Lu R.B....Chou Y.H. (Alcohol. Clin. Exp. Res. 2005)
    221. Alcohol drinking frequency is more directly associated with alcohol use disorder than alcohol metabolizing enzymes among male Japanese. (PubMed id 15679538)1, 4 Nishiyori A....Fukuda K. (Psychiatry Clin. Neurosci. 2005)
    222. Genetic polymorphisms of CYP2E1, GSTT1, GSTP1, GSTM1, ALDH2, and ODC and the risk of advanced precancerous gastric lesions in a Chinese population. (PubMed id 15734972)1, 4 You W.C....Gail M.H. (amp 2005)
    223. Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes. (PubMed id 15242332)1, 2 Aboulaich N.... Vener A.V. (Biochem. J. 2004)
    224. Association of ALDH(2) genotypes and alcohol consumption with periodontitis. (PubMed id 14742656)1, 4 Nishida N....Shizukuishi S. (J. Dent. Res. 2004)
    225. Pooled analysis of alcohol dehydrogenase genotypes and head and neck cancer: a HuGE review. (PubMed id 14693654)1, 4 Brennan P....Benhamou S. (Am. J. Epidemiol. 2004)
    226. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    227. Genetic polymorphisms in three Iranian populations with different risks of esophageal cancer, an ecologic comparison. (PubMed id 15327835)1, 4 Sepehr A....Dawsey S.M. (Cancer Lett. 2004)
    228. Genetic analysis of 22 candidate genes for hypertension in the Japanese population. (PubMed id 15167446)1, 4 Iwai N....Shioji K. (J. Hypertens. 2004)
    229. Relation of genotypes of alcohol metabolizing enzymes and mortality of liver diseases in patients with alcohol dependence. (PubMed id 15511718)1, 4 Chen C.C....Yin S.J. (Addict Biol 2004)
    230. Alcohol flushing, alcohol and aldehyde dehydrogenase genotypes, and risk for esophageal squamous cell carcinoma in Japanese men. (PubMed id 14652286)1, 4 Yokoyama T....Yoshimizu H. (amp 2003)
    231. Allelic variation at alcohol metabolism genes ( ADH1B, ADH1C, ALDH2) and alcohol dependence in an American Indian population. (PubMed id 12884000)1, 4 Mulligan C.J....Long J.C. (Hum. Genet. 2003)
    232. [Relationship between ALDH gene polymorphism and alcoholic liver diseases]. (PubMed id 14636437)1, 4 Yan M....Wu M.L. (Zhonghua Gan Zang Bing Za Zhi 2003)
    233. Age-dependent changes in electroencephalographic responses to alcohol consumption in subjects with aldehyde dehydrogenase-2 genetic variations. (PubMed id 12766630)1, 4 Nishimura F.T....Nishijo H. (Alcohol. Clin. Exp. Res. 2003)
    234. Aldehyde dehydrogenase 2 genotypes, alcohol flushing symptoms and drinking patterns in Thai men. (PubMed id 12759156)1, 4 Assanangkornchai S....Ratanachaiyavong S. (Psychiatry Res 2003)
    235. Alcohol dependence symptoms and alcohol dehydrogenase 2 polymorphism: Israeli Ashkenazis, Sephardics, and recent Russian immigrants. (PubMed id 12351924)1, 4 Hasin D....Li T.K. (Alcohol. Clin. Exp. Res. 2002)
    236. Allele Frequencies of 25 Polymorphisms Pertaining to Cancer Risk for Japanese, Koreans and Chinese. (PubMed id 12718576)1, 4 Hamajima N....Tajima K. (Asian Pac. J. Cancer Prev. 2002)
    237. Lifestyle habits and genetic susceptibility and the risk of esophageal cancer in the Thai population. (PubMed id 12213289)1, 4 Boonyaphiphat P....Puttawibul P. (Cancer Lett. 2002)
    238. Effects of aldehyde dehydrogenase-2 genetic polymorphisms on metabolism of structurally different aldehydes in human liver. (PubMed id 11744614)1, 4 Wang R.S....Honma T. (Drug Metab. Dispos. 2002)
    239. Interaction between alcohol dehydrogenase II gene, alcohol consumption, and risk for breast cancer. (PubMed id 12189549)1, 4 StA1rmer T....Brenner H. (Br. J. Cancer 2002)
    240. Assessment of a difference in ALDH2 heterozygotes and alcoholic liver injury. (PubMed id 12198368)1, 4 Nagata N....Matsuzaki S. (Alcohol. Clin. Exp. Res. 2002)
    241. Aldehyde dehydrogenase 2 (ALDH2) genotype affects rectal cancer susceptibility due to alcohol consumption. (PubMed id 12033531)1, 4 Matsuo K....Tajima K. (J Epidemiol 2002)
    242. Genetic risk for alcoholism relates to level of response to alcohol in Asian-American men and women. (PubMed id 11925062)1, 4 Luczak S.E....Wall T.L. (J. Stud. Alcohol 2002)
    243. Genetic differences in ethanol metabolizing enzymes and blood pressure in Japanese alcohol consumers. (PubMed id 12080432)1, 4 Yamada Y....Honda R. (J Hum Hypertens 2002)
    244. Contribution of genetic polymorphisms in ethanol-metabolizing enzymes to problem drinking behavior in middle-aged Japanese men. (PubMed id 12211622)1, 4 Sun F....Yamada Y. (Behav. Genet. 2002)
    245. Relationship between genetic polymorphisms of alcohol-metabolizing enzymes and changes in risk factors for coronary heart disease associated with alcohol consumption. (PubMed id 12089173)1, 4 Hashimoto Y....Nakahara K. (Clin. Chem. 2002)
    246. The aldehyde dehydrogenase 2 gene is a risk factor for hypertension in Japanese but does not alter the sensitivity to pressor effects of alcohol: the Suita study. (PubMed id 11510748)1, 4 Takagi S....Ogihara T. (Hypertens. Res. 2001)
    247. Polymorphism of the neuropeptide Y gene: an association study with alcohol withdrawal. (PubMed id 11410744)1, 4 Okubo T. and Harada S. (Alcohol. Clin. Exp. Res. 2001)
    248. Human liver mitochondrial aldehyde dehydrogenase: three-dimensional structure and the restoration of solubility and activity of chimeric forms. (PubMed id 10631996)1, 2 Ni L.... Weiner H. (Protein Sci. 1999)
    249. Mitochondrial aldehyde dehydrogenase polymorphism in Asian and American Indian populations: detection of new ALDH2 alleles. (PubMed id 8561277)1, 2 Novoradovsky A....Goldman D. (Alcohol. Clin. Exp. Res. 1995)
    250. Genomic structure of the human mitochondrial aldehyde dehydrogenase gene. (PubMed id 2838413)1, 2 Hsu L.C.... Yoshida A. (Genomics 1988)
    251. Mitochondrial aldehyde dehydrogenase. Homology of putative targeting sequence to that of carbamyl phosphate synthetase I revealed by correlation of cDNA and protein data. (PubMed id 3653404)1, 2 Hempel J.... Joernvall H. (FEBS Lett. 1987)
    252. Human aldehyde dehydrogenase isozymes and alcohol sensitivity. (PubMed id 3610592)1, 2 Agarwal D.P. and Goedde H.W. (Isozymes Curr. Top. Biol. Med. Res. 1987)
    253. Evidence for a signal peptide at the amino-terminal end of human mitochondrial aldehyde dehydrogenase. (PubMed id 3582651)1, 2 Braun T.... Goedde H.W. (FEBS Lett. 1987)
    254. Isolation and sequence analysis of a full length cDNA clone coding for human mitochondrial aldehyde dehydrogenase. (PubMed id 3562250)1, 2 Braun T.... Goedde H.W. (Nucleic Acids Res. 1987)
    255. Mitochondrial aldehyde dehydrogenase from human liver. Primary structure, differences in relation to the cytosolic enzyme, and functional correlations. (PubMed id 4065146)1, 2 Hempel J.... Joernvall H. (Eur. J. Biochem. 1985)
    256. Molecular abnormality of an inactive aldehyde dehydrogenase variant commonly found in Orientals. (PubMed id 6582480)1, 2 Yoshida A.... Ikawa M. (Proc. Natl. Acad. Sci. U.S.A. 1984)
    257. Aldehyde dehydrogenase 2 in cardiac protection: a new therapeutic target? (PubMed id 20005475)1, 9 Budas G.R....Mochly-Rosen D. (Trends Cardiovasc. Med. 2009)
    258. Chaperonin GroESL mediates the protein folding of human liver mitochondrial aldehyde dehydrogenase in Escherichia coli. (PubMed id 12387818)1, 9 Lee K.H....Lee Y.S. (Biochem. Biophys. Res. Commun. 2002)
    259. [Aldehyde dehydrogenase 2(ALDH2) gene polymorphism in NIDDM patients with chronic renal failure]. (PubMed id 9752691)4, 9 Kuriyama S....Hosoya T. (Nihon Jinzo Gakkai Shi 1998)
    260. Dominance of the mutant ALDH2(2) allele in the expression of human stomach aldehyde dehydrogenase-2 activity. (PubMed id 8290656)1, 9 Chao Y.C....Yin S.J. (Proc. Natl. Sci. Counc. Repub. China B 1993)
    261. [Association between aldehyde dehydrogenase-2/cytochrome P450 2E1 genetic polymorphism and habit of alcohol drinking and the susceptibility of hepatocellular carcinoma]. (PubMed id 20364586)1, 9 Ye X....Li L. (Wei Sheng Yan Jiu 2010)
    262. Inactive aldehyde dehydrogenase-2 increased the risk of pancreatic cancer among smokers in a Japanese male population. (PubMed id 15714130)1, 9 Miyasaka K....Funakoshi A. (Pancreas 2005)
    263. Aldehyde dehydrogenase 2 plays a role in the bioactivation of nitroglycerin in humans. (PubMed id 16051882)7, 9 Mackenzie I.S....Wilkinson I.B. (Arterioscler. Thromb. Vasc. Biol. 2005)
    264. Mitochondrial ALDH2 deficiency as an oxidative stress. (PubMed id 15126281)1, 9 Ohta S....Shimokata H. (Ann. N. Y. Acad. Sci. 2004)
    265. A promoter polymorphism in the ALDH2 gene affects its basal and acetaldehyde/ethanol-induced gene expression in human peripheral blood leukocytes and HepG2 cells. (PubMed id 19144977)1, 9 Kimura Y....Saijoh K. (Alcohol Alcohol. 2009)
    266. Effect of aldehyde dehydrogenase-2 genotype on cardiac autonomic nervous responses to moderate alcohol ingestion. (PubMed id 18540919)1, 9 Akamatsu Y....Moritani T. (Alcohol. Clin. Exp. Res. 2008)
    267. Application of aldehyde dehydrogenase 2 (ALDH2) genetic diagnosis in support of decreasing alcohol intake. (PubMed id 16788276)1, 9 Komiya Y....Katoh T. (J Occup Health 2006)
    268. Contribution of aldehyde dehydrogenase to mitochondrial bioactivation of nitroglycerin: evidence for the activation of purified soluble guanylate cyclase through direct formation of nitric oxide. (PubMed id 15377279)1, 9 Kollau A....Mayer B. (Biochem. J. 2005)
    269. Molecular cloning, baculovirus expression, and tissue distribution of the zebrafish aldehyde dehydrogenase 2. (PubMed id 15703303)1, 9 Lassen N....Vasiliou V. (Drug Metab. Dispos. 2005)
    270. [Distribution of genotypes of alcohol dehydrogenase 2 and aldehyde dehydrogenase 2 in Japanese twin children]. (PubMed id 11864460)4, 9 Qu W....Zhang Y. (Zhonghua Yu Fang Yi Xue Za Zhi 1999)
    271. Effects of ALDH2, CYP1A1, and CYP2E1 genetic polymorphisms and smoking and drinking habits on toluene metabolism in humans. (PubMed id 7645026)7, 9 Kawamoto T....Kodama Y. (Toxicol. Appl. Pharmacol. 1995)
    272. Role of the general base Glu-268 in nitroglycerin bioactivation and superoxide formation by aldehyde dehydrogenase-2. (PubMed id 19506075)1, 9 Wenzl M.V....Mayer B. (J. Biol. Chem. 2009)
    273. Efficient expression of codon-adapted human acetaldehyde dehydrogenase 2 cDNA with 6xHis tag in Pichia pastoris. (PubMed id 19911129)1, 9 Zhao Y....Wang C. (Sci. China, C, Life Sci. 2009)
    274. Inhibition of aldehyde dehydrogenase type 2 attenuates vasodilatory action of nitroglycerin in human veins. (PubMed id 18272654)1, 9 Huellner M.W....Rau T. (FASEB J. 2008)
    275. Distribution of alcohol-metabolizing enzyme genotypes in trauma patients with excessive alcohol consumption in the emergency department. (PubMed id 17292341)1, 9 Tseng Y.M....Tsai L.Y. (Clin. Biochem. 2007)
    276. Genotoxic effects of alcohol in human peripheral lymphocytes modulated by ADH1B and ALDH2 gene polymorphisms. (PubMed id 17207821)1, 9 Ishikawa H....Yokoyama K. (Mutat. Res. 2007)
    277. Tissue-distribution of aldehyde dehydrogenase 2 and effects of the ALDH2 gene-disruption on the expression of enzymes involved in alcohol metabolism. (PubMed id 15569633)1, 9 Oyama T....Kawamoto T. (Front. Biosci. 2005)
    278. A PBPK model for evaluating the impact of aldehyde dehydrogenase polymorphisms on comparative rat and human nasal tissue acetaldehyde dosimetry. (PubMed id 18302046)1, 9 Teeguarden J.G....Jarabek A.M. (Inhal Toxicol 2008)
    279. Rapid, accurate genotyping of alcohol dehydrogenase-1B and aldehyde dehydrogenase-2 based on the use of denaturing HPLC. (PubMed id 16309369)1, 9 Li L....Xu X.M. (Clin. Chem. Lab. Med. 2005)
    280. Genetic polymorphisms of ADH2, ADH3, CYP4502E1 Dra-I and Pst-I, and ALDH2 in Spanish men: lack of association with alcoholism and alcoholic liver disease. (PubMed id 15519646)1, 9 Vidal F....Richart C. (J. Hepatol. 2004)
    281. Partially irreversible inactivation of mitochondrial aldehyde dehydrogenase by nitroglycerin. (PubMed id 18786921)1, 9 Beretta M....Gorren A.C. (J. Biol. Chem. 2008)
    282. [The relationship between aldehyde dehydrogenase-2 gene polymorphisms and efficacy of nitroglycerin]. (PubMed id 17967228)4, 9 Zhang H....Zhang Y. (Zhonghua Nei Ke Za Zhi 2007)
    283. Increased DNA damage in ALDH2-deficient alcoholics. (PubMed id 17040107)1, 9 Matsuda T....Yokoyama A. (Chem. Res. Toxicol. 2006)
    284. Genetic associations of alcohol and aldehyde dehydrogenase with alcohol dependence and their mechanisms of action. (PubMed id 16404797)1, 9 Wall T.L. (Ther Drug Monit 2005)
    285. Association of polymorphisms in nicotinic acetylcholine receptor alpha 4 subunit gene (CHRNA4), mu-opioid receptor gene (OPRM1), and ethanol-metabolizing enzyme genes with alcoholism in Korean patients. (PubMed id 15902904)1, 9 Kim S.A....Chung J.H. (Alcohol 2004)
    286. Duplex polymerase chain reaction with confronting two-pair primers (PCR-CTPP) for genotyping alcohol dehydrogenase beta subunit (ADH2) and aldehyde dehydrogenase 2 (ALDH2). (PubMed id 12915514)1, 9 Tamakoshi A....Tajima K. (Alcohol Alcohol. 2003)
    287. Association of restriction fragment-length polymorphisms in the alcohol dehydrogenase 2 gene with alcoholic brain atrophy. (PubMed id 8659684)4, 9 Maezawa Y....Sakurai S. (Alcohol. Clin. Exp. Res. 1996)
    288. Variability in ethanol biodisposition in whites is modulated by polymorphisms in the ADH1B and ADH1C genes. (PubMed id 20101753)1, 9 MartA-nez C....AgA_ndez J.A. (Hepatology 2010)
    289. Alda-1 is an agonist and chemical chaperone for the common human aldehyde dehydrogenase 2 variant. (PubMed id 20062057)1, 9 Perez-Miller S....Hurley T.D. (amp 2010)
    290. DNA polymorphism and risk of esophageal squamous cell carcinoma in a population of North Xinjiang, China. (PubMed id 20128036)4, 9 Ma W.J....Lu X.M. (World J. Gastroenterol. 2010)
    291. Characterization of the East Asian variant of aldehyde dehydrogenase-2: bioactivation of nitroglycerin and effects of Alda-1. (PubMed id 19906643)1, 9 Beretta M....Mayer B. (J. Biol. Chem. 2010)
    292. 5HTT polymorphisms are associated with job stress in Japanese workers. (PubMed id 19251454)1, 9 Katsuyama H....Saijoh K. (Leg Med (Tokyo) 2009)
    293. Lipid hydroperoxides in human plasma after ethanol consumption. (PubMed id 19261511)1, 9 Asano M....Ueno Y. (Leg Med (Tokyo) 2009)
    294. Alcohol and genetic polymorphisms: effect on risk of alcohol-related cancer. (PubMed id 19185835)1, 9 Druesne-Pecollo N....Latino-Martel P. (Lancet Oncol. 2009)
    295. Detoxification of promutagenic aldehydes derived from methylpyrenes by human aldehyde dehydrogenases ALDH2 and ALDH3A1. (PubMed id 18621017)1, 9 Glatt H....Kollock R. (Arch. Biochem. Biophys. 2008)
    296. Association of the aldehyde dehydrogenase 2 promoter polymorphism with alcohol consumption and reactions in an American Jewish population. (PubMed id 17850643)1, 9 Fischer M....Crabb D.W. (Alcohol. Clin. Exp. Res. 2007)
    297. Effect of -361 G/A polymorphism of aldehyde dehydrogenase-2 gene on alcohol metabolism and its expression in human peripheral blood leukocytes. (PubMed id 16734278)1, 9 Nishimura F.T....Saijoh K. (amp 2006)
    298. Disruption of the coenzyme binding site and dimer interface revealed in the crystal structure of mitochondrial aldehyde dehydrogenase &quot;Asian&quot; variant. (PubMed id 15983043)1, 9 Larson H.N....Hurley T.D. (J. Biol. Chem. 2005)
    299. Influence of genetic admixture on polymorphisms of alcohol-metabolizing enzymes: analyses of mutations on the CYP2E1, ADH2, ADH3 and ALDH2 genes in a Mexican-American population living in the Los Angeles area. (PubMed id 12554615)1, 9 Konishi T....Wan Y.J. (Alcohol Alcohol. 2003)
    300. Relation among alcohol dehydrogenase 2 polymorphism, alcohol consumption, and levels of gamma-glutamyltransferase. (PubMed id 12798968)1, 9 Loew M....Brenner H. (Alcohol 2003)
    301. Identification of a retinoid receptor response element in the human aldehyde dehydrogenase-2 promoter. (PubMed id 14691372)1, 9 Pinaire J....Crabb D. (Alcohol. Clin. Exp. Res. 2003)
    302. Tandem repeat polymorphism of the CYP2E1 gene: an association study with esophageal cancer and lung cancer. (PubMed id 12198369)1, 9 Itoga S....Harada S. (Alcohol. Clin. Exp. Res. 2002)
    303. XRCC1 and CYP2E1 polymorphisms as susceptibility factors of plasma mutant p53 protein and anti-p53 antibody expression in vinyl chloride monomer-exposed polyvinyl chloride workers. (PubMed id 12010862)1, 9 Wong R.H....Cheng T.J. (amp 2002)
    304. Detection of usual and atypical aldehyde dehydrogenase alleles by mismatch amplification mutation assay. (PubMed id 11798074)1, 9 Luo H.R....Zhang Y.P. (Clin. Chem. Lab. Med. 2001)
    305. Association of aldehyde dehydrogenase 2 gene polymorphism with multiple oesophageal dysplasia in head and neck cancer patients. (PubMed id 10896918)4, 9 Muto M....Esumi H. (Gut 2000)
    306. A novel polymorphism (-357 G/A) of the ALDH2 gene: linkage disequilibrium and an association with alcoholism. (PubMed id 10397278)4, 9 Harada S....Tsutsumi M. (Alcohol. Clin. Exp. Res. 1999)
    307. Correlation between alcohol-induced asthma and acetaldehyde dehydrogenase-2 genotype. (PubMed id 9600491)4, 9 Takao A....Harda S. (J. Allergy Clin. Immunol. 1998)
    308. Binding and activation of the human aldehyde dehydrogenase 2 promoter by hepatocyte nuclear factor 4. (PubMed id 9765594)1, 9 Stewart M.J....Crabb D.W. (Biochim. Biophys. Acta 1998)
    309. Genetic polymorphism of cytochrome P-4502E1 and mitochondrial aldehyde dehydrogenase in a Korean population. (PubMed id 9309300)1, 9 Lee K.H.... Jeong H.S. (Alcohol. Clin. Exp. Res. 1997)
    310. Molecular genetics of human aldehyde dehydrogenase. (PubMed id 1306115)1, 9 Yoshida A. (Pharmacogenetics 1992)
    311. Targeting aldehyde dehydrogenase 2: new therapeutic opportunities. (PubMed id 24382882)1 Chen C.H....Mochly-Rosen D. (Physiol. Rev. 2014)
    312. Common variants of the ALDH2 and DHDH genes and the risk of Dupuytren's disease. (PubMed id 23303836)1 Zyluk A....Puchalski P. (J Hand Surg Eur Vol 2013)
    313. Aldehyde dehydrogenase-2 inhibition blocks remote preconditioning in experimental and human models. (PubMed id 23525499)1 Contractor H....Kharbanda R.K. (Basic Res. Cardiol. 2013)
    314. Effect of alcohol and aldehyde dehydrogenase gene polymorphisms on alcohol-associated hypertension: the Guangzhou Biobank Cohort Study. (PubMed id 23615284)1 Zhang W.S....Lam T.H. (Hypertens. Res. 2013)
    315. Comparative genomics, molecular evolution and computational modeling of ALDH1B1 and ALDH2. (PubMed id 23247008)1 Jackson B.C....Vasiliou V. (Chem. Biol. Interact. 2013)
    316. Mitochondrial aldehyde dehydrogenase-2 activation prevents I^-amyloid-induced endothelial cell dysfunction and restores angiogenesis. (PubMed id 23447675)1 Solito R....Donnini S. (J. Cell. Sci. 2013)
    317. Alpha-lipoic acid ameliorates oxidative stress by increasing aldehyde dehydrogenase-2 activity in patients with acute coronary syndrome. (PubMed id 23238616)1 Li R.J....Zhang Y. (Tohoku J. Exp. Med. 2013)
    318. Single nucleotide polymorphisms of ADH1B, ADH1C and ALDH2 genes and esophageal cancer: a population-based case-control study in China. (PubMed id 22930414)1 Wu M....Zhang Z.F. (Int. J. Cancer 2013)
    319. The aldehyde dehydrogenase 2 (ALDH2) Glu504Lys polymorphism interacts with alcohol drinking in the risk of stomach cancer. (PubMed id 23455379)1 Matsuo K....Tanaka H. (Carcinogenesis 2013)
    320. Variant ALDH2 is associated with accelerated progression of bone marrow failure in Japanese Fanconi anemia patients. (PubMed id 24037726)1 Hira A....Yabe M. (Blood 2013)
    321. Telomere shortening in the esophagus of Japanese alcoholics: relationships with chromoendoscopic findings, ALDH2 and ADH1B genotypes and smoking history. (PubMed id 23667679)1 Aida J....Takubo K. (PLoS ONE 2013)
    322. Association between DRD2, 5-HTTLPR, and ALDH2 genes and specific personality traits in alcohol- and opiate-dependent patients. (PubMed id 23685324)1 Wang T.Y....Lu R.B. (Behav. Brain Res. 2013)
    323. Common variants at 12q24 are associated with drinking behavior in Han Chinese. (PubMed id 23364009)1 Yang X....Gu D. (Am. J. Clin. Nutr. 2013)
    324. ALDH2 rs671 Polymorphism and coronary heart disease risk among Asian populations: a meta-analysis and meta-regression. (PubMed id 23697560)1 Wang Q....Jin Y. (DNA Cell Biol. 2013)
    325. Trends in gastrectomy and ADH1B and ALDH2 genotypes in Japanese alcoholic men and their gene-gastrectomy, gene-gene and gene-age interactions for risk of alcoholism. (PubMed id 23296215)1 Yokoyama A....Maruyama K. (Alcohol Alcohol. 2013)
    326. Genetic polymorphisms of alcohol dehydrogenase-1B and aldehyde dehydrogenase-2 and liver cirrhosis, chronic calcific pancreatitis, diabetes mellitus, and hypertension among Japanese alcoholic men. (PubMed id 23550892)1 Yokoyama A....Maruyama K. (Alcohol. Clin. Exp. Res. 2013)
    327. MicroRNA-34a promotes cardiomyocyte apoptosis post myocardial infarction through down-regulating aldehyde dehydrogenase 2. (PubMed id 23323620)1 Fan F....Ge J. (Curr. Pharm. Des. 2013)
    328. Mitochondrial aldehyde dehydrogenase obliterates endoplasmic reticulum stress-induced cardiac contractile dysfunction via correction of autophagy. (PubMed id 23354068)1 Zhang B....Ren J. (Biochim. Biophys. Acta 2013)
    329. Association of a functional single-nucleotide polymorphism in the ALDH2 gene with essential hypertension depends on drinking behavior in a Chinese Han population. (PubMed id 22551939)1 Wang Y....Zhu D. (J Hum Hypertens 2013)
    330. Association of genetic polymorphisms in ADH and ALDH2 with risk of coronary artery disease and myocardial infarction: a meta-analysis. (PubMed id 23685282)1 Han H....Han J. (Gene 2013)
    331. [Dose effect of alcohol on sex differences in blood alcohol metabolism--cases where healthy subjects with ALDH2*1/1 genotype drunk beer with meal]. (PubMed id 23986996)1 Oshima S....Ohno Y. (amp 2013)
    332. Interaction between novelty seeking and the aldehyde dehydrogenase 2 gene in heroin-dependent patients. (PubMed id 23609397)1 Lee S.Y....Lu R.B. (J Clin Psychopharmacol 2013)
    333. The ADH1B and DRD2 gene polymorphism may modify the protective effect of the ALDH2 gene against heroin dependence. (PubMed id 23266708)1 Wang T.Y....Lu R.B. (amp 2013)
    334. Catalytic contribution of threonine 244 in human ALDH2. (PubMed id 23295226)1 GonzA!lez-Segura L....Hurley T.D. (Chem. Biol. Interact. 2013)
    335. Mitochondrial NAD dependent aldehyde dehydrogenase either from yeast or human replaces yeast cytoplasmic NADP dependent aldehyde dehydrogenase for the aerobic growth of yeast on ethanol. (PubMed id 23454351)1 Mukhopadhyay A....Weiner H. (Biochim. Biophys. Acta 2013)
    336. The combination of mitochondrial low enzyme-activity aldehyde dehydrogenase 2 allele and superoxide dismutase 2 genotypes increases the risk of hypertension in relation to alcohol consumption. (PubMed id 23111423)1 Nakagawa T....Nakagawa K. (Pharmacogenet. Genomics 2013)
    337. A genome-wide association study of a coronary artery disease risk variant. (PubMed id 23364394)1 Lee J.Y....Lee J.Y. (J. Hum. Genet. 2013)
    338. Association of the ALDH1A1*2 promoter polymorphism with alcohol phenotypes in young adults with or without ALDH2*2. (PubMed id 22591209)1 Otto J.M....Wall T.L. (Alcohol. Clin. Exp. Res. 2013)
    339. ALDH, CA I, and CD2AP: novel, diagnostically useful immunohistochemical markers to identify erythroid precursors in bone marrow biopsy specimens. (PubMed id 22180476)1 Rollins-Raval M.A....Roth C.G. (Am. J. Clin. Pathol. 2012)
    340. Strong protective effect of the aldehyde dehydrogenase gene (ALDH2) 504lys (*2) allele against alcoholism and alcohol-induced medical diseases in Asians. (PubMed id 22102315)1 Li D....Gelernter J. (Hum. Genet. 2012)
    341. Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies. (PubMed id 23041239)1 Traylor M....Markus H.S. (Lancet Neurol 2012)
    342. Genetic risk of hepatocellular carcinoma in patients with hepatitis C virus: a case control study. (PubMed id 22004425)1 Tomoda T....Shimizu K. (J. Gastroenterol. Hepatol. 2012)
    343. SET overexpression decreases cell detoxification efficiency: ALDH2 and GSTP1 are downregulated, DDR is impaired and DNA damage accumulates. (PubMed id 23106910)1 Almeida L.O....Leopoldino A.M. (FEBS J. 2012)
    344. COMT and ALDH2 polymorphisms moderate associations of implicit drinking motives with alcohol use. (PubMed id 21309949)1 Hendershot C.S....Hutchison K.E. (Addict Biol 2012)
    345. Combination of ADH1B*2/ALDH2*2 polymorphisms alters acetaldehyde-derived DNA damage in the blood of Japanese alcoholics. (PubMed id 22703580)1 Yukawa Y....Matsuda T. (Cancer Sci. 2012)
    346. Folate, alcohol, and aldehyde dehydrogenase 2 polymorphism and the risk of oral and pharyngeal cancer in Japanese. (PubMed id 21946912)1 Matsuo K....La Vecchia C. (Eur. J. Cancer Prev. 2012)
    347. Acetylation-dependent regulation of mitochondrial ALDH2 activation by SIRT3 mediates acute ethanol-induced eNOS activation. (PubMed id 22155639)1 Xue L....Chen Y. (FEBS Lett. 2012)
    348. Breath alcohol elimination rate and Widmark factor derived from breath alcohol concentration in Chinese and Indians in Singapore. (PubMed id 22287615)1 Limenta L.M....Lee E.J. (Alcohol Alcohol. 2012)
    349. Association of genetic polymorphisms of aldehyde dehydrogenase-2 and cytochrome P450 2E1-RsaI and alcohol consumption with oral squamous cell carcinoma. (PubMed id 22954124)1 Guo L.K....Guo X.F. (Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2012)
    350. The acute effects of ethanol and acetaldehyde on physiological responses after ethanol ingestion in young healthy men with different ALDH2 genotypes. (PubMed id 22455355)1 Bae K.Y....Yoon J.S. (Clin Toxicol (Phila) 2012)
    351. Alcohol dehydrogenase and aldehyde dehydrogenase gene polymorphisms, alcohol intake and the risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition study. (PubMed id 23149980)1 Ferrari P....Riboli E. (Eur J Clin Nutr 2012)
    352. Association of an aldehyde dehydrogenase 2 (ALDH2) gene polymorphism with hyper-low-density lipoprotein cholesterolemia in a Japanese population. (PubMed id 22870576)1 Kotani K....Yamada T. (amp 2012)
    353. Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations. (PubMed id 22797727)1 Okada Y....Tanaka T. (Nat. Genet. 2012)
    354. Developmental trajectory and environmental moderation of the effect of ALDH2 polymorphism on alcohol use. (PubMed id 22563891)1 Irons D.E....McGue M. (Alcohol. Clin. Exp. Res. 2012)
    355. Vascular bioactivation of nitroglycerin by aldehyde dehydrogenase-2: reaction intermediates revealed by crystallography and mass spectrometry. (PubMed id 22988236)1 Lang B.S....Gruber K. (J. Biol. Chem. 2012)
    356. Genetic variation in alcohol dehydrogenase (ADH1A, ADH1B, ADH1C, ADH7) and aldehyde dehydrogenase (ALDH2), alcohol consumption and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. (PubMed id 22144473)1 Duell E.J....GonzA!lez C.A. (Carcinogenesis 2012)
    357. Genetic polymorphisms of ALDH2 and ADH2 are not associated with risk of hepatocellular carcinoma among East Asians. (PubMed id 22231434)1 Zhou D....Yang Y. (Tumour Biol. 2012)
    358. The aldehyde dehydrogenase 2 gene is associated with heroin dependence. (PubMed id 21723677)1 Wang T.Y....Lu R.B. (Drug Alcohol Depend 2012)
    359. Evaluation of moderate alcohol use and cognitive function among men using a Mendelian randomization design in the Guangzhou biobank cohort study. (PubMed id 22302076)1 Au Yeung S.L....Schooling C.M. (Am. J. Epidemiol. 2012)
    360. [ALDH2 polymorphisms and clinical medicine]. (PubMed id 22708399)1 Yoshihara T. and Sasaguri T. (Fukuoka Igaku Zasshi 2012)
    361. Genome-wide association analyses of esophageal squamous cell carcinoma in Chinese identify multiple susceptibility loci and gene-environment interactions. (PubMed id 22960999)1 Wu C....Lin D. (Nat. Genet. 2012)
    362. Interaction between ALDH2*1*1 and DRD2/ANKK1 TaqI A1A1 genes may be associated with antisocial personality disorder not co-morbid with alcoholism. (PubMed id 21070510)1 Lu R.B....Ko H.C. (Addict Biol 2012)
    363. Influence of ALDH2 Glu504Lys polymorphism on nitroglycerin response in chronic heart failure and involvement of Calcitonin Gene Related Peptide (CGRP). (PubMed id 22909898)1 Peng L.M....Li C.C. (Int J Clin Pharmacol Ther 2012)
    364. ADH and ALDH polymorphisms and alcohol dependence in Mexican and Native Americans. (PubMed id 22931071)1 Ehlers C.L....Gizer I.R. (Am J Drug Alcohol Abuse 2012)
    365. Dysplastic lesions in inflammatory bowel disease show increased positivity for the stem cell marker aldehyde dehydrogenase. (PubMed id 21820149)1 Toll A.D....Palazzo J.P. (Hum. Pathol. 2012)
    366. Aldehyde-stress resulting from Aldh2 mutation promotes osteoporosis due to impaired osteoblastogenesis. (PubMed id 22508505)1 Hoshi H....Miyamoto T. (J. Bone Miner. Res. 2012)
    367. Effect of mitochondrial aldehyde dehydrogenase-2 genotype on cardioprotection in patients with congenital heart disease. (PubMed id 22507973)1 Zhang H....Hu S. (Eur. Heart J. 2012)
    368. Heavy binge drinking may increase risk of stroke in nonalcoholic hypertensives carrying variant ALDH2*2 gene allele. (PubMed id 22879089)1 Lai C.L....Peng G.S. (Acta Neurol Taiwan 2012)
    369. Alcohol drinking, mean corpuscular volume of erythrocytes, and alcohol metabolic genotypes in drunk drivers. (PubMed id 21917409)1 Pavanello S....Montisci M. (Alcohol 2012)
    370. Common ALDH2 genetic variants predict development of hypertension in the SAPPHIRe prospective cohort: gene-environmental interaction with alcohol consumption. (PubMed id 22839215)1 Chang Y.C....Chuang L.M. (BMC Cardiovasc Disord 2012)
    371. The ALDH2 and 5-HT2A genes interacted in bipolar-I but not bipolar-II disorder. (PubMed id 22564712)1 Lee S.Y....Lu R.B. (amp 2012)
    372. [Alcohol metabolism at moderate drinking in healthy men. Comparison between differences of alcohol beverages, with and without meal, and genetic polymorphism]. (PubMed id 21861333)1 Oshima S....Ohno Y. (amp 2011)
    373. Esophageal squamous cell carcinoma and ALDH2 and ADH1B polymorphisms in Chinese females. (PubMed id 22292652)1 Wang Y....Xia S. (Asian Pac. J. Cancer Prev. 2011)
    374. Meta-analysis of aldehyde dehydrogenase 2 gene polymorphism and Alzheimer's disease in East Asians. (PubMed id 21515512)1 Hao P.P....Zhang Y. (Can J Neurol Sci 2011)
    375. ALDH2 and ADH1B interactions in retrospective reports of low-dose reactions and initial sensitivity to alcohol in Asian American college students. (PubMed id 21355870)1 Luczak S.E....Wall T.L. (Alcohol. Clin. Exp. Res. 2011)
    376. Modification of the relationship between urinary 8-OHdG and hippuric acid concentration by GSTM1, GSTT1, and ALDH2 genotypes. (PubMed id 20488846)1 Kim Y.D....Kim H. (amp 2011)
    377. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    378. Genetic testing for aldehyde dehydrogenase 2 deficiency in young adults. (PubMed id 21321583)1 Hendershot C.S. (Pharmacogenomics J. 2011)
    379. p53 protein accumulation, iodine-unstained lesions, and alcohol dehydrogenase-1B and aldehyde dehydrogenase-2 genotypes in Japanese alcoholic men with esophageal dysplasia. (PubMed id 21601984)1 Yokoyama A....Omori T. (Cancer Lett. 2011)
    380. Association between alcohol intake and risk for gastric cancer with regard to ALDH2 genotype in the Korean population. (PubMed id 21507992)1 Shin C.M....Song I.S. (Int J Epidemiol 2011)
    381. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    382. Alcohol ingestion and colorectal neoplasia: a meta-analysis based on a Mendelian randomization approach. (PubMed id 21114754)1 Wang J....Zhang Y. (Colorectal Dis 2011)
    383. [Genetic polymorphism of ADH3 and ALDH2 among Tibetan population in Qinghai and its relationship with drinking behavior]. (PubMed id 22279680)1 Liu Y....Zhang B. (Wei Sheng Yan Jiu 2011)
    384. The role of ALDH2 and ADH1B polymorphism in alcohol consumption and stroke in Han Chinese. (PubMed id 22155604)1 Yao C.T....Peng G.S. (Hum. Genomics 2011)
    385. Gender differences in the effects of ADH1B and ALDH2 polymorphisms on alcoholism. (PubMed id 21848961)1 Kimura M....Higuchi S. (Alcohol. Clin. Exp. Res. 2011)
    386. Deficiency of insulin-like growth factor 1 reduces vulnerability to chronic alcohol intake-induced cardiomyocyte mechanical dysfunction: role of AMPK. (PubMed id 20731752)1 Ge W....Ren J. (J. Cell. Mol. Med. 2011)
    387. Genome-wide association studies identify genetic loci related to alcohol consumption in Korean men. (PubMed id 21270382)1 Baik I....Shin C. (Am. J. Clin. Nutr. 2011)
    388. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    389. A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium. (PubMed id 21437268)1 McKay J.D....Brennan P. (PLoS Genet. 2011)
    390. Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians. (PubMed id 21572416)1 Kato N....He J. (Nat. Genet. 2011)
    391. Evaluating a cognitive model of ALDH2 and drinking behavior. (PubMed id 21039630)1 Hendershot C.S....Larimer M.E. (Alcohol. Clin. Exp. Res. 2011)
    392. Regulation of human mitochondrial aldehyde dehydrogenase (ALDH-2) activity by electrophiles in vitro. (PubMed id 21252222)1 Oelze M....Daiber A. (J. Biol. Chem. 2011)
    393. ADH1B and ALDH2 polymorphisms and their associations with increased risk of squamous cell carcinoma of the head and neck in the Korean population. (PubMed id 21576033)1 Ji Y.B....Shin H.D. (Oral Oncol. 2011)
    394. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    395. ALDH2 in alcoholic heart diseases: molecular mechanism and clinical implications. (PubMed id 21664374)1 Zhang Y. and Ren J. (amp 2011)
    396. Acetaldehyde dehydrogenase 2 SNP rs671 and susceptibility to essential hypertension in Mongolians: a case control study. (PubMed id 21476199)1 Hasi T....Su X.L. (Genet. Mol. Res. 2011)
    397. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    398. Site-directed mutagenesis of aldehyde dehydrogenase-2 suggests three distinct pathways of nitroglycerin biotransformation. (PubMed id 21536753)1 Wenzl M.V....Gorren A.C. (Mol. Pharmacol. 2011)
    399. Multi-susceptibility genes associated with the risk of the development stages of esophageal squamous cell cancer in Feicheng County. (PubMed id 21672255)1 Li Q.D....Li Q.H. (BMC Gastroenterol 2011)
    400. Role of aldehyde dehydrogenase 2 Glu504lys polymorphism in acute coronary syndrome. (PubMed id 21958412)1 Xu F....Zhang Y. (J. Cell. Mol. Med. 2011)
    401. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (Cell 2010)
    402. Alcohol dehydrogenase 2 genotype and risk for migraine. (PubMed id 19486361)1 GarcA-a-MartA-n E....JimAcnez-JimAcnez F.J. (Headache 2010)
    403. Sex-specific proteome differences in the anterior cingulate cortex of schizophrenia. (PubMed id 20381070)1 Martins-de-Souza D....Turck C.W. (J Psychiatr Res 2010)
    404. Mitochondrial aldehyde dehydrogenase mediates vasodilator responses of glyceryl trinitrate and sodium nitrite in the pulmonary vascular bed of the rat. (PubMed id 20543077)7 Badejo A.M....Kadowitz P.J. (Am. J. Physiol. Heart Circ. Physiol. 2010)
    405. Network organization of the human autophagy system. (PubMed id 20562859)1 Behrends C....Harper J.W. (Nature 2010)
    406. Polymorphisms of alcohol dehydrogenase-1B and aldehyde dehydrogenase-2 and the blood and salivary ethanol and acetaldehyde concentrations of Japanese alcoholic men. (PubMed id 20477767)1 Yokoyama A....Yokoyama T. (Alcohol. Clin. Exp. Res. 2010)
    407. A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome. (PubMed id 20186120)1 Richter R....Chrzanowska-Lightowlers Z.M. (EMBO J. 2010)
    408. Alcohol dehydrogenase-2 and aldehyde dehydrogenase-2 genotypes, alcohol drinking and the risk for stomach cancer in Chinese males. (PubMed id 21133627)1 Cao H.X....Ding J.H. (Asian Pac. J. Cancer Prev. 2010)
    409. Evaluation of the use of self-reported facial flushing and ethanol patch test for ALDH2 genotypes. (PubMed id 21222353)4 Ishibashi T....Harada S. (amp 2010)
    410. High ALDH activity identifies chemotherapy-resistant Ewing's sarcoma stem cells that retain sensitivity to EWS-FLI1 inhibition. (PubMed id 21085683)1 Awad O....Loeb D.M. (PLoS ONE 2010)
    411. MAOA interacts with the ALDH2 gene in anxiety-depression alcohol dependence. (PubMed id 20477771)1 Lee S.Y....Lu R.B. (Alcohol. Clin. Exp. Res. 2010)
    412. The ALDH2 and DRD2/ANKK1 genes interacted in bipolar II but not bipolar I disorder. (PubMed id 20577142)1 Lee S.Y....Lu R.B. (Pharmacogenet. Genomics 2010)
    413. Deficient aldehyde dehydrogenase 2 is associated with increased risk for esophageal squamous cell carcinoma in the presence of gastric hypochlorhydria. (PubMed id 20521872)1 Oikawa T....Shimosegawa T. (Scand. J. Gastroenterol. 2010)
    414. Single-nucleotide polymorphisms, acute rejection, and severity of tubulitis in kidney transplantation, accounting for center-to-center variation. (PubMed id 21085059)4 Israni A....Oetting W.S. (Transplantation 2010)
    415. Genetic variation in 3-hydroxy-3-methylglutaryl CoA reductase modifies the chemopreventive activity of statins for colorectal cancer. (PubMed id 20403997)1 Lipkin S.M....Gruber S.B. (Cancer Prev Res (Phila) 2010)
    416. Distribution of ADH1B, ALDH2, CYP2E1 *6, and CYP2E1 *7B genotypes in Turkish population. (PubMed id 20598484)1 KayaaltA+ Z. and SAPylemezoA9lu T. (Alcohol 2010)
    417. Candidate gene polymorphisms for diabetes mellitus, cardiovascular disease and cancer are associated with longevity in Koreans. (PubMed id 19641380)1 Park J.W....Park J. (amp 2009)
    418. Transgenic overexpression of aldehyde dehydrogenase-2 rescues chronic alcohol intake-induced myocardial hypertrophy and contractile dysfunction. (PubMed id 19332462)1 Doser T.A....Ren J. (Circulation 2009)
    419. Effect of the allelic variants of aldehyde dehydrogenase ALDH2*2 and alcohol dehydrogenase ADH1B*2 on blood acetaldehyde concentrations. (PubMed id 19164089)1 Peng G.S. and Yin S.J. (Hum. Genomics 2009)
    420. Aldehyde dehydrogenase activity among primary leukemia cells is associated with stem cell features and correlates with adverse clinical outcomes. (PubMed id 19819294)1 Ran D....Ho A.D. (Exp. Hematol. 2009)
    421. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)
    422. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PubMed id 19056867)1 Gonzales P.A....Knepper M.A. (J. Am. Soc. Nephrol. 2009)
    423. [Molecular genetics of alcohol dependence]. (PubMed id 18516948)1 Ujike H. (amp 2008)
    424. Statistical analysis of the associations between polymorphisms within aldehyde dehydrogenase 2 (ALDH2), and quantitative and qualitative traits extracted from a large-scale database of Japanese single-nucleotide polymorphisms (SNPs). (PubMed id 18317873)1 Nose J....Kamatani N. (J. Hum. Genet. 2008)
    425. Bioactivation of nitroglycerin by purified mitochondrial and cytosolic aldehyde dehydrogenases. (PubMed id 18450747)1 Beretta M....Mayer B. (J. Biol. Chem. 2008)
    426. Estimation of single-nucleotide polymorphism allele frequency by alternately binding probe competitive polymerase chain reaction. (PubMed id 18215653)1 Noda N....Sekiguchi Y. (Anal. Chim. Acta 2008)
    427. The association of ADH and ALDH gene variants with alcohol drinking habits and cardiovascular disease risk factors. (PubMed id 18782342)1 Husemoen L.L....Linneberg A. (Alcohol. Clin. Exp. Res. 2008)
    428. Health risk appraisal models for mass screening of esophageal cancer in Japanese men. (PubMed id 18843030)4 Yokoyama T....Watanabe H. (amp 2008)
    429. Real-time PCR genotyping of aldehyde dehydrogenase-2 using displacing probes. (PubMed id 17854793)1 Gu Y. and Li Q. (Clin. Biochem. 2007)
    430. The activity of class I, II, III, and IV of alcohol dehydrogenase isoenzymes and aldehyde dehydrogenase in pancreatic cancer. (PubMed id 17632320)1 Jelski W....Szmitkowski M. (Pancreas 2007)
    431. The role of acetaldehyde in upper digestive tract cancer in alcoholics. (PubMed id 17543846)1 Seitz H.K. and Meier P. (Transl Res 2007)
    432. Sex differences, alcohol dehydrogenase, acetaldehyde burst, and aversion to ethanol in the rat: a systems perspective. (PubMed id 17488809)7 Quintanilla M.E....Israel Y. (Am. J. Physiol. Endocrinol. Metab. 2007)
    433. Refractive hypotension in a patient with disulfiram-ethanol reaction. (PubMed id 17220694)7 Ho M.P....Lee C.C. (Am. J. Med. Sci. 2007)
    434. How many drug targets are there? (PubMed id 17139284)7 Overington J.P....Hopkins A.L. (Nat Rev Drug Discov 2006)
    435. Drugs, their targets and the nature and number of drug targets. (PubMed id 17016423)7 Imming P....Meyer A. (Nat Rev Drug Discov 2006)
    436. Mitochondrial aldehyde dehydrogenase attenuates hyperoxia-induced cell death through activation of ERK/MAPK and PI3K-Akt pathways in lung epithelial cells. (PubMed id 16782756)1 Xu D....Truog W.E. (Am. J. Physiol. Lung Cell Mol. Physiol. 2006)
    437. ALDH2 genotype-associated differences in the acute effects of alcohol on P300, psychomotor performance, and subjective response in healthy young Korean men: a double-blind placebo-controlled crossover study. (PubMed id 16565959)1 Shin H.Y....Yoon J.S. (Hum Psychopharmacol 2006)
    438. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)2 Scherer S.E.... Gibbs R.A. (Nature 2006)
    439. The UChA and UChB rat lines: metabolic and genetic differences influencing ethanol intake. (PubMed id 16961761)7 Quintanilla M.E....Tampier L. (Addict Biol 2006)
    440. Certain background factors exhibit an association with an increased risk for pancreatic calcification among Japanese male alcoholics. (PubMed id 16163053)1 Nakamura Y....Maruyama K. (Pancreas 2005)
    441. Inhibition of mitochondrial aldehyde dehydrogenase by nitric oxide-mediated S-nitrosylation. (PubMed id 16242127)7 Moon K.H....Song B.J. (FEBS Lett. 2005)
    442. ALDH2 genotype is associated in the relation between alcohol intake and periodontitis. (PubMed id 17138329)1 Merchant A.T. (J Evid Based Dent Pract 2005)
    443. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (Cell 2005)
    444. Comparative analyses of four different methods of genotyping ALDH2. (PubMed id 15318097)1 Itoga S....Nomura F. (Alcohol. Clin. Exp. Res. 2004)
    445. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    446. The evolution and population genetics of the ALDH2 locus: random genetic drift, selection, and low levels of recombination. (PubMed id 15008789)1 Oota H....Kidd K.K. (Ann. Hum. Genet. 2004)
    447. ALDH2 status and conduct disorder mediate the relationship between ethnicity and alcohol dependence in Chinese, Korean, and White American college students. (PubMed id 15122947)1 Luczak S.E....Carr L.G. (J Abnorm Psychol 2004)
    448. Aldehyde dehydrogenase 2 genotype in type 1 diabetes mellitus. (PubMed id 12706323)1 Suzuki Y....Matsuoka K. (Diabetes Res. Clin. Pract. 2003)
    449. Candidate genes for alcohol dependence: a review of genetic evidence from human studies. (PubMed id 12766633)4 Dick D.M. and Foroud T. (Alcohol. Clin. Exp. Res. 2003)
    450. Maternal inheritance of diabetes is associated with inactive ALDH2 genotype in diabetics with renal failure in Japanese. (PubMed id 12706324)1 Suzuki Y....Ohta S. (Diabetes Res. Clin. Pract. 2003)
    451. Coenzyme isomerization is integral to catalysis in aldehyde dehydrogenase. (PubMed id 12795606)1 Perez-Miller S.J. and Hurley T.D. (Biochemistry 2003)
    452. Low-penetrance genes and their involvement in colorectal cancer susceptibility. (PubMed id 12433710)4 de Jong M.M....Kleibeuker J.H. (amp 2002)
    453. Effects of alcohol intake on ambulatory blood pressure, heart rate, and heart rate variability in Japanese men with different ALDH2 genotypes. (PubMed id 12082496)1 Minami J....Matsuoka H. (J Hum Hypertens 2002)
    454. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    455. Genetic variation in aldehyde dehydrogenase 2 and the effect of alcohol consumption on cholesterol levels. (PubMed id 12119207)1 Nakamura Y....Ueshima H. (Atherosclerosis 2002)
    456. Effects of aldehyde dehydrogenase-2 genotype on cardiovascular and endocrine responses to alcohol in young Japanese subjects. (PubMed id 12492137)1 Nishimura F.T....Nishijo H. (amp 2002)
    457. Alcohol dehydrogenase-2*2 allele is associated with decreased prevalence of fetal alcohol syndrome in the mixed-ancestry population of the Western Cape Province, South Africa. (PubMed id 11781503)4 Viljoen D.L....Li T.K. (Alcohol. Clin. Exp. Res. 2001)
    458. The N-terminal portion of mature aldehyde dehydrogenase affects protein folding and assembly. (PubMed id 11468345)1 Zhou J. and Weiner H. (Protein Sci. 2001)
    459. The Protein Data Bank. (PubMed id 10592235)7 Berman H.M....Bourne P.E. (Nucleic Acids Res. 2000)
    460. Allele association studies with SSR and SNP markers at known physical distances within a 1 Mb region embracing the ALDH2 locus in the Japanese, demonstrates linkage disequilibrium extending up to 400 kb. (PubMed id 11115843)1 Koch H.G....Craig I.W. (Hum. Mol. Genet. 2000)
    461. HBV/HCV Infection, Alcohol, Tobacco and Genetic Polymorphisms for Hepatocellular Carcinoma in Nagoya, Japan. (PubMed id 12718671)1 Koide T....Tokudome S. (Asian Pac. J. Cancer Prev. 2000)
    462. Structure of mitochondrial aldehyde dehydrogenase: the genetic component of ethanol aversion. (PubMed id 9195888)1 Steinmetz C.G....Hurley T.D. (Structure 1997)
    463. The mutation in the mitochondrial aldehyde dehydrogenase (ALDH2) gene responsible for alcohol-induced flushing increases turnover of the enzyme tetramers in a dominant fashion. (PubMed id 8903321)1 Xiao Q....Crabb D.W. (J. Clin. Invest. 1996)
    464. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (Genome Res. 1996)
    465. The aldehyde dehydrogenase ALDH2*2 allele exhibits dominance over ALDH2*1 in transduced HeLa cells. (PubMed id 7593603)1 Xiao Q....Crabb D.W. (J. Clin. Invest. 1995)
    466. Association of a restriction fragment length polymorphism in the alcohol dehydrogenase 2 gene with Japanese alcoholic liver cirrhosis. (PubMed id 8583138)4 Yamauchi M....Sakurai S. (J. Hepatol. 1995)
    467. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (Gene 1994)
    468. Genotypes for aldehyde dehydrogenase deficiency and alcohol sensitivity. The inactive ALDH2(2) allele is dominant. (PubMed id 2562960)1 Crabb D.W....Li T.K. (J. Clin. Invest. 1989)
    469. Genotypes of alcohol-metabolizing enzymes in Japanese with alcohol liver diseases: a strong association of the usual Caucasian-type aldehyde dehydrogenase gene (ALDH1(2)) with the disease. (PubMed id 3189338)4 Shibuya A. and Yoshida A. (Am. J. Hum. Genet. 1988)
    470. The structural gene for the mitochondrial aldehyde dehydrogenase maps to human chromosome 12. (PubMed id 3017845)1 Braun T....Goedde H.W. (Hum. Genet. 1986)
    471. Expression of aldehyde dehydrogenase 2 in the normal esophageal epithelium and alcohol consumption in patients with esophageal cancer. (PubMed id 15970497)9 Morita M....Yasumoto K. (Front. Biosci. 2005)
    472. Inactive aldehyde dehydrogenase 2 worsens glycemic control in patients with type 2 diabetes mellitus who drink low to moderate amounts of alcohol. (PubMed id 10803771)9 Murata C....Okazaki I. (Alcohol. Clin. Exp. Res. 2000)
    473. Genotyping of the aldehyde dehydrogenase 2 (ALDH2) gene using the polymerase chain reaction: evidence for single point mutation in the ALDH2 gene of ALDH2-deficiency. (PubMed id 1916152)9 Enomoto N....Date T. (Gastroenterol. Jpn. 1991)
    474. Association of aldehyde dehydrogenase with inheritance of NIDDM. (PubMed id 8877297)9 Suzuki Y....Matsuoka K. (Diabetologia 1996)
    475. Effect of ALDH2 and CYP2E1 gene polymorphisms on drinking behavior and alcoholic liver disease in Japanese male workers. (PubMed id 11410736)9 Okamoto K....Kawasaki H. (Alcohol. Clin. Exp. Res. 2001)
    476. Suppression of heavy drinking and alcohol seeking by a selective ALDH-2 inhibitor. (PubMed id 19673742)9 Arolfo M.P....Diamond I. (Alcohol. Clin. Exp. Res. 2009)
    477. RNA interference against aldehyde dehydrogenase-2: development of tools for alcohol research. (PubMed id 19251111)9 CortA-nez G....Israel Y. (Alcohol 2009)
    478. Attenuation of acetaldehyde-induced cell injury by overexpression of aldehyde dehydrogenase-2 (ALDH2) transgene in human cardiac myocytes: role of MAP kinase signaling. (PubMed id 16403513)9 Li S.Y....Ren J. (J. Mol. Cell. Cardiol. 2006)
    479. Simultaneous genotyping of alcohol dehydrogenase 2 (ADH2) and aldehyde dehydrogenase 2 (ALDH2) loci by amplified product length polymorphism (APLP) analysis. (PubMed id 9629893)9 Aoshima T....Suzuki T. (Electrophoresis 1998)
    480. [Application of polymerase chain reaction with confronting two-pair primers in aldehyde dehydrogenase-2 typing]. (PubMed id 18642666)9 Ye X.P....Li L.Q. (Zhonghua Yu Fang Yi Xue Za Zhi 2008)
    481. Decrease in endogenous CGRP release in nitroglycerin tolerance: role of ALDH-2. (PubMed id 17585900)9 Chen Y.R....Li Y.J. (Eur. J. Pharmacol. 2007)
    482. [Effects of ethanol ingestion on glucose tolerance in people with different genotypes of ALDH2]. (PubMed id 16316071)9 Negoro M....Wakabayashi I. (amp 2005)
    483. Overexpression of aldehyde dehydrogenase-2 (ALDH2) transgene prevents acetaldehyde-induced cell injury in human umbilical vein endothelial cells: role of ERK and p38 mitogen-activated protein kinase. (PubMed id 14722101)9 Li S.Y....Ren J. (J. Biol. Chem. 2004)
    484. Nucleotide sequence diversity in non-coding regions of ALDH2 as revealed by restriction enzyme and SSCP analysis. (PubMed id 10190330)9 Peterson R.J....Long J.C. (Hum. Genet. 1999)
    485. Multiple primary esophageal and concurrent upper aerodigestive tract cancer and the aldehyde dehydrogenase-2 genotype of Japanese alcoholics. (PubMed id 8640660)9 Yokoyama A....Ishii H. (Cancer 1996)
    486. Polymorphisms of ethanol-oxidizing enzymes in alcoholics with inactive ALDH2. (PubMed id 8834237)9 Higuchi S....Hayashida M. (Hum. Genet. 1996)
    487. Apparent monomorphism of ALDH2 in seven American Indian populations. (PubMed id 7772269)9 Novoradovsky A.G....Goldman D. (Alcohol 1995)
    488. Acetaldehyde metabolism in different aldehyde dehydrogenase-2 genotypes. (PubMed id 2024727)9 Enomoto N....Takada A. (Alcohol. Clin. Exp. Res. 1991)
    489. Substrate specificity of human and yeast aldehyde dehydrogenases. (PubMed id 18983993)9 Wang M.F....Yin S.J. (Chem. Biol. Interact. 2009)
    490. Single nucleotide polymorphism detection in aldehyde dehydrogenase 2 (ALDH2) gene using bacterial magnetic particles based on dissociation curve analysis. (PubMed id 15329927)9 Maruyama K....Matsunaga T. (Biotechnol. Bioeng. 2004)
    491. Hepatitis B and C viruses infection, lifestyle and genetic polymorphisms as risk factors for hepatocellular carcinoma in Haimen, China. (PubMed id 12495467)9 Yu S.Z....Tokudome S. (Jpn. J. Cancer Res. 2002)
    492. [Classification of alcohol metabolizing enzymes and polymorphisms--specificity in Japanese]. (PubMed id 11398342)9 Harada S. (amp 2001)
    493. Alcohol-related cancers and aldehyde dehydrogenase-2 in Japanese alcoholics. (PubMed id 9744533)9 Yokoyama A....Ishii H. (Carcinogenesis 1998)
    494. Inhibition of recombinant human mitochondrial and cytosolic aldehyde dehydrogenases by two candidates for the active metabolites of disulfiram. (PubMed id 9354647)9 Lam J.P....Lipsky J.J. (Biochemistry 1997)
    495. Distribution of messenger RNAs for aldehyde dehydrogenase 1, aldehyde dehydrogenase 2, and aldehyde dehydrogenase 5 in human tissues. (PubMed id 8689400)9 Stewart M.J....Crabb D.W. (J. Investig. Med. 1996)
    496. Mitochondrial aldehyde dehydrogenase in diabetes associated with mitochondrial tRNA(Leu(UUR)) mutation at position 3243. (PubMed id 8941476)9 Suzuki Y....Matsuoka K. (Diabetes Care 1996)
    497. CYP2E1 and ALDH2 genotypes and alcohol dependence in Japanese. (PubMed id 7573775)9 Iwahashi K....Ichikawa Y. (Alcohol. Clin. Exp. Res. 1995)
    498. Alcohol and aldehyde dehydrogenase polymorphisms and the risk for alcoholism. (PubMed id 7625477)9 Higuchi S....Hayashida M. (Am J Psychiatry 1995)
    499. Distribution of urinary hippuric acid concentrations by ALDH2 genotype. (PubMed id 7849865)9 Kawamoto T....Kodama Y. (Occup Environ Med 1994)
    500. Low-Km aldehyde dehydrogenase deficiency does not influence the elevation of blood pressure by alcohol. (PubMed id 8006921)9 Okayama A....Kita Y. (J Hum Hypertens 1994)
    501. [Contribution of the ALDH2 and CYP2E1 genes to flushing response and drinking patterns in Japanese healthy volunteers]. (PubMed id 8267522)9 Iwahashi K....Orino K. (amp 1993)
    502. Activation of aldehyde dehydrogenase-2 reduces ischemic damage to the heart. (PubMed id 18787169)9 Chen C.H....Mochly-Rosen D. (Science 2008)
    503. Prolonged central sensory conduction time in alcoholics with hypoactive aldehyde dehydrogenase-2. (PubMed id 15380331)9 Mochizuki H....Higuchi S. (Neurosci. Res. 2004)
    504. Genetic deficiency of a mitochondrial aldehyde dehydrogenase increases serum lipid peroxides in community-dwelling females. (PubMed id 12905081)9 Ohsawa I....Ohta S. (J. Hum. Genet. 2003)
    505. ALDH2 status, alcohol expectancies, and alcohol response: preliminary evidence for a mediation model. (PubMed id 11707629)9 McCarthy D.M....Wall T.L. (Alcohol. Clin. Exp. Res. 2001)
    506. Biological markers of alcoholism with respect to genotypes of low-Km aldehyde dehydrogenase (ALDH2) in Japanese subjects. (PubMed id 10803776)9 Nomura F....Nakai T. (Alcohol. Clin. Exp. Res. 2000)
    507. Aldehyde dehydrogenase (ALDH) 2 associates with oxidation of methoxyacetaldehyde; in vitro analysis with liver subcellular fraction derived from human and Aldh2 gene targeting mouse. (PubMed id 10913633)9 Kitagawa K....Nakayama K. (FEBS Lett. 2000)
    508. The role of alcohol dehydrogenase 2 and aldehyde dehydrogenase 2 genotypes in alcohol-induced vasospastic angina. (PubMed id 10503603)9 Seki T....Kasahara S. (Tohoku J. Exp. Med. 1999)
    509. Self-reported alcohol-associated symptoms and drinking behavior in three ALDH2 genotypes among Japanese university students. (PubMed id 10397292)9 Takeshita T. and Morimoto K. (Alcohol. Clin. Exp. Res. 1999)
    510. Inhibition of recombinant human mitochondrial aldehyde dehydrogenase by two intermediate metabolites of disulfiram. (PubMed id 9605433)9 Mays D.C....Lipsky J.J. (Biochem. Pharmacol. 1998)
    511. Short-term follow-up after endoscopic mucosectomy of early esophageal cancer and aldehyde dehydrogenase-2 genotype in Japanese alcoholics. (PubMed id 9641490)9 Yokoyama A....Ishii H. (amp 1998)
    512. Study on Parkinson's disease and alcohol drinking. (PubMed id 10028826)9 Fujii C....Yoshizawa K. (amp 1998)
    513. Simple and rapid determination of the acetaldehyde dehydrogenase (ALDH2) genotypes by nonradioactive single-strand conformation polymorphism analysis. (PubMed id 9420148)9 Yuasa I....Irizawa Y. (Electrophoresis 1997)
    514. Reliability of a flushing questionnaire and the ethanol patch test in screening for inactive aldehyde dehydrogenase-2 and alcohol-related cancer risk. (PubMed id 9419411)9 Yokoyama A....Ishii H. (amp 1997)
    515. Kinetics and specificity of human liver aldehyde dehydrogenases toward aliphatic, aromatic, and fused polycyclic aldehydes. (PubMed id 8605195)9 Klyosov A.A. (Biochemistry 1996)
    516. ALDH2 polymorphism and biological monitoring of toluene. (PubMed id 7944563)9 Kawamoto T....Matsuda S. (Arch. Environ. Health 1994)
    517. The relationship between low Km aldehyde dehydrogenase phenotype and drinking behavior in Japanese. (PubMed id 1560668)9 Higuchi S....Harford T.C. (J. Stud. Alcohol 1992)
    518. The oxidative stress concept of nitrate tolerance and the antioxidant properties of hydralazine. (PubMed id 16226933)9 Daiber A....MA1nzel T. (Am. J. Cardiol. 2005)
    519. Simultaneous genotyping of alcohol dehydrogenase 2 and aldehyde dehydrogenase 2 by single-strand conformation polymorphism analysis. (PubMed id 14743955)9 Sakata R....Fukuda K. (Scand. J. Clin. Lab. Invest. 2003)
    520. Transcriptional control of the human aldehyde dehydrogenase 2 promoter by hepatocyte nuclear factor 4: inhibition by cyclic AMP and COUP transcription factors. (PubMed id 11811951)9 You M....Crabb D. (Arch. Biochem. Biophys. 2002)
    521. Synthesis of potential antidipsotropic isoflavones: inhibitors of the mitochondrial monoamine oxidase-aldehyde dehydrogenase pathway. (PubMed id 11563931)9 Gao G.Y....Keung W.M. (J. Med. Chem. 2001)
    522. The effects of the ALDH2*1/2, CYP2E1 C1/C2 and C/D genotypes on blood ethanol elimination. (PubMed id 10826103)9 Yoshihara E....Iwahashi K. (Drug Chem Toxicol 2000)
    523. Genetic polymorphisms of tobacco- and alcohol-related metabolizing enzymes and human esophageal squamous cell carcinoma susceptibility. (PubMed id 9451664)9 Hori H....Yuasa Y. (J. Clin. Gastroenterol. 1997)
    524. Alcoholism and alcoholic organ damage and genetic polymorphisms of alcohol metabolizing enzymes in Chinese patients. (PubMed id 8985275)9 Chao Y.C....Hsu C.T. (Hepatology 1997)
    525. Alcohol-metabolising genes and alcoholism among Taiwanese Han men: independent effect of ADH2, ADH3 and ALDH2. (PubMed id 8773821)9 Chen W.J....Cheng A.T. (Br J Psychiatry 1996)
    526. Characteristics of Japanese alcoholics with the atypical aldehyde dehydrogenase 2*2. I. A comparison of the genotypes of ALDH2, ADH2, ADH3, and cytochrome P-4502E1 between alcoholics and nonalcoholics. (PubMed id 8651462)9 Nakamura K....Suwaki H. (Alcohol. Clin. Exp. Res. 1996)
    527. Genetic polymorphism of alcohol and aldehyde dehydrogenase and the effects on alcohol metabolism. (PubMed id 8512495)9 Yamamoto K....Tatsuno Y. (amp 1993)
    528. Cloning and characterization of a new functional human aldehyde dehydrogenase gene. (PubMed id 2061311)9 Hsu L.C. and Chang W.-C. (J. Biol. Chem. 1991)
    529. Alcohol drinking, cigarette smoking, and the development of squamous cell carcinoma of the esophagus: epidemiology, clinical findings, and prevention. (PubMed id 20224884)9 Morita M....Maehara Y. (Int. J. Clin. Oncol. 2010)
    530. Effects of acetaldehyde inhalation in mitochondrial aldehyde dehydrogenase deficient mice (Aldh2-/-). (PubMed id 20515806)9 Oyama T....Kawamoto T. (Front Biosci (Elite Ed) 2010)
    531. Acetaldehyde as a common denominator and cumulative carcinogen in digestive tract cancers. (PubMed id 19396661)9 Salaspuro M. (Scand. J. Gastroenterol. 2009)
    532. Aldehyde dehydrogenase (ALDH) 3A1 expression by the human keratocyte and its repair phenotypes. (PubMed id 16822507)9 Pei Y....McDermott A.M. (Exp. Eye Res. 2006)
    533. Bioelectronic sniffers for ethanol and acetaldehyde in breath air after drinking. (PubMed id 15626611)9 Mitsubayashi K....Nakanishi Y. (amp 2005)
    534. Paired acute inhalation test reveals that acetaldehyde toxicity is higher in aldehyde dehydrogenase 2 knockout mice than in wild-type mice. (PubMed id 16404141)9 Isse T....Kawamoto T. (J Toxicol Sci 2005)
    535. Risk of multiple squamous cell carcinomas both in the esophagus and the head and neck region. (PubMed id 15718256)9 Muto M....Esumi H. (Carcinogenesis 2005)
    536. Kimchi and soybean pastes are risk factors of gastric cancer. (PubMed id 15929164)9 Nan H.M....Kim H. (World J. Gastroenterol. 2005)
    537. Genetic polymorphisms of alcohol and aldehyde dehydrogenases and risk for esophageal and head and neck cancers. (PubMed id 12672787)9 Yokoyama A. and Omori T. (Jpn. J. Clin. Oncol. 2003)
    538. Anti-dipsotropic isoflavones: the potential therapeutic agents for alcohol dependence. (PubMed id 12939789)9 Keung W.M. (Med Res Rev 2003)
    539. Association of a polymorphism of the serotonin 1B receptor gene and alcohol dependence with inactive aldehyde dehydrogenase-2. (PubMed id 11956970)9 Hasegawa Y....Miyaoka H. (J Neural Transm 2002)
    540. Proteomic alterations of the variants of human aldehyde dehydrogenase isozymes correlate with hepatocellular carcinoma. (PubMed id 11774273)9 Park K.S....Paik Y.K. (Int. J. Cancer 2002)
    541. Association between smoking, acetaldehyde dehydrogenase-2 1-1 status, and alcohol drinking among Taiwanese polyvinyl chloride workers. (PubMed id 11515253)9 Lin Y.P....Cheng T.J. (J. Occup. Environ. Med. 2001)
    542. [Alcohol and oropharyngolaryngeal and digestive tract cancer]. (PubMed id 11828713)9 Yokoyama A. and Omori T. (amp 2001)
    543. Relationship between alcohol drinking, ADH2 and ALDH2 genotypes, and risk for hepatocellular carcinoma in Japanese. (PubMed id 10737710)9 Takeshita T....Morimoto K. (Cancer Lett. 2000)
    544. Hangover symptoms in Asian Americans with variations in the aldehyde dehydrogenase (ALDH2) gene. (PubMed id 10627091)9 Wall T.L....Carr L.G. (J. Stud. Alcohol 2000)
    545. Association of genetic polymorphisms of alcohol-metabolizing enzymes with excessive alcohol consumption in Japanese men. (PubMed id 10543395)9 Sun F....Yamada Y. (Hum. Genet. 1999)
    546. Genetic polymorphism of aldehyde dehydrogenase 2 in patients with upper aerodigestive tract cancer. (PubMed id 10235272)9 Tanabe H....Kohgo Y. (Alcohol. Clin. Exp. Res. 1999)
    547. Alcohol and aldehyde dehydrogenase gene polymorphisms influence susceptibility to esophageal cancer in Japanese alcoholics. (PubMed id 10591585)9 Yokoyama A....Ishii H. (Alcohol. Clin. Exp. Res. 1999)
    548. No association between DRD2 locus and alcoholism after controlling the ADH and ALDH genotypes in Chinese Han population. (PubMed id 10235293)9 Lee J.F....Kidd K.K. (Alcohol. Clin. Exp. Res. 1999)
    549. Effects of genetic polymorphism of metabolic enzymes, nutrition, and lifestyle factors on DNA adduct formation in lymphocytes. (PubMed id 9810147)9 Wang Y....Tomokuni K. (Ind Health 1998)
    550. Allele frequency of ADH2 and ALDH2 among Brazilians of different ethnic groups. (PubMed id 9160796)9 Santos B.R....Thomasson H.R. (Alcohol 1997)
    551. Genotypes of aldehyde dehydrogenase and alcohol dehydrogenase polymorphisms in patients with Leber's hereditary optic neuropathy. (PubMed id 9183998)9 Isashiki Y....Ohba N. (Jpn. J. Hum. Genet. 1997)
    552. Polymorphism of alcohol-metabolizing genes affects drinking behavior and alcoholic liver disease in Japanese men. (PubMed id 9194910)9 Tanaka F....Omata M. (Alcohol. Clin. Exp. Res. 1997)
    553. Daidzin inhibits mitochondrial aldehyde dehydrogenase and suppresses ethanol intake of Syrian golden hamsters. (PubMed id 9050837)9 Keung W.M....Vallee B.L. (Proc. Natl. Acad. Sci. U.S.A. 1997)
    554. Ethanol and acetaldehyde metabolism in chinese with different aldehyde dehydrogenase-2 genotypes. (PubMed id 7480358)9 Luu S.U....Yin S.J. (Proc. Natl. Sci. Counc. Repub. China B 1995)
    555. A study on ADH2 and ALDH2 genotyping by PCR-RFLP and SSCP analyses with description of allele and genotype frequencies in Japanese, Finn and Lapp populations. (PubMed id 9063814)9 Suzuki K....Fukunaga T. (Alcohol Alcohol Suppl 1994)
    556. Polymorphisms of ethanol metabolizing enzyme genes and alcoholism. (PubMed id 8974313)9 Higuchi S. (Alcohol Alcohol Suppl 1994)
    557. [Relationship between alcoholism and genotypes of acetaldehyde-metabolizing enzymes]. (PubMed id 8135667)9 Iwahashi K....Orino K. (amp 1994)
    558. Involvement of genetic polymorphism of alcohol and aldehyde dehydrogenases in individual variation of alcohol metabolism. (PubMed id 7695788)9 Mizoi Y....Harada S. (Alcohol Alcohol. 1994)
    559. Biological monitoring of toluene and DNA polymorphism in humans. (PubMed id 8406909)9 Kawamoto T....Kodama Y. (Int Arch Occup Environ Health 1993)
    560. [Genetic and epidemiologic studies on alcoholic liver diseases]. (PubMed id 8267523)9 Harada S....Takada A. (amp 1993)
    561. [Aldehyde dehydrogenase activity of blood serum exposed to different concentrations of acetaldehyde]. (PubMed id 8160299)9 Kharchenko N.K. and SinitskiA- V.N. (Ukr. Biokhim. Zh. 1993)
    562. Identification of human liver aldehyde dehydrogenases that catalyze the oxidation of aldophosphamide and retinaldehyde. (PubMed id 1610409)9 Dockham P.A....Sladek N.E. (Biochem. Pharmacol. 1992)
    563. Distribution of ADH2 and ALDH2 genotypes in different populations. (PubMed id 1733836)9 Goedde H.W....Lisker R. (Hum. Genet. 1992)
    564. Investigation of the role of polymorphisms at the alcohol and aldehyde dehydrogenase loci in genetic predisposition to alcohol-related end-organ damage. (PubMed id 1937384)9 Day C.P....Edenberg H.J. (Hepatology 1991)
    565. Nitrate reductase activity of mitochondrial aldehyde dehydrogenase (ALDH-2) as a redox sensor for cardiovascular oxidative stress. (PubMed id 20072908)9 Daiber A. and MA1nzel T. (Methods Mol. Biol. 2010)
    566. Primate-accelerated evolutionary genes: novel routes to drug discovery in psychiatric disorders. (PubMed id 20166940)9 Moalic J.M....Simonneau M. (Curr. Med. Chem. 2010)
    567. The influence of genetic polymorphisms on population variability in six xenobiotic-metabolizing enzymes. (PubMed id 20183525)9 Ginsberg G....Sonawane B. (J Toxicol Environ Health B Crit Rev 2009)
    568. Nitrate tolerance as a model of vascular dysfunction: roles for mitochondrial aldehyde dehydrogenase and mitochondrial oxidative stress. (PubMed id 19307691)9 Daiber A....MA1nzel T. (Pharmacol Rep 2009)
    569. Mendelian randomization: how it can--and cannot--help confirm causal relations between nutrition and cancer. (PubMed id 19174578)9 Schatzkin A....Davey-Smith G. (Cancer Prev Res (Phila) 2009)
    570. Single-tube genotyping from a human hair root by direct PCR. (PubMed id 20009340)9 Hayashida M....Kinoshita K. (Anal Sci 2009)
    571. Effect of a small dose of alcohol on driving-related behavior of Japanese who self-reported facial flush and nonflushing. (PubMed id 20178264)9 Fujita G. and Nishida Y. (Percept Mot Skills 2009)
    572. Effect of pentachlorophenol and 2,6-dichloro-4-nitrophenol on the activity of cDNA-expressed human alcohol and aldehyde dehydrogenases. (PubMed id 19822198)9 Kollock R....Glatt H. (Toxicol. Lett. 2009)
    573. Demethylbellidifolin prevents nitroglycerin tolerance via improved aldehyde dehydrogenase 2 activity. (PubMed id 19533580)9 Shi R.Z....Zhang G.G. (Planta Med. 2009)
    574. Chronic atrophic gastritis and metachronous gastric cancer in Japanese alcoholic men with esophageal squamous cell carcinoma. (PubMed id 19320631)9 Yokoyama A....Maruyama K. (Alcohol. Clin. Exp. Res. 2009)
    575. Mitochondrial aldehyde dehydrogenase (ALDH-2)--maker of and marker for nitrate tolerance in response to nitroglycerin treatment. (PubMed id 18834868)9 Daiber A....MA1nzel T. (Chem. Biol. Interact. 2009)
    576. Mitochondrial nitrite reduction coupled to soluble guanylate cyclase activation: lack of evidence for a role in the bioactivation of nitroglycerin. (PubMed id 18951990)9 Kollau A....Mayer B. (Nitric Oxide 2009)
    577. Human aldehyde dehydrogenase-catalyzed oxidation of ethylene glycol ether aldehydes. (PubMed id 18940187)9 Gross A....Sreerama L. (Chem. Biol. Interact. 2009)
    578. Role of aldehyde dehydrogenase-2 in alcoholic liver disease. (PubMed id 19215230)9 Youtz D.J. and Wold L.E. (amp 2009)
    579. Involvement of the endothelial DDAH/ADMA pathway in nitroglycerin tolerance: the role of ALDH-2. (PubMed id 18289604)9 Zhang G.G....Li Y.J. (Life Sci. 2008)
    580. The enigma of nitroglycerin bioactivation and nitrate tolerance: news, views and troubles. (PubMed id 18574453)9 Mayer B. and Beretta M. (Br. J. Pharmacol. 2008)
    581. ALDH-2 deficiency increases cardiovascular oxidative stress--evidence for indirect antioxidative properties. (PubMed id 18157936)9 Wenzel P....Daiber A. (Biochem. Biophys. Res. Commun. 2008)
    582. Prohibitin identified by proteomic analysis of prostate biopsies distinguishes hyperplasia and cancer. (PubMed id 18384941)9 Ummanni R....Walther R. (Cancer Lett. 2008)
    583. Association between serotonin transporter gene polymorphisms and depressed mood caused by job stress in Japanese workers. (PubMed id 18360696)9 Katsuyama H....Sunami S. (Int. J. Mol. Med. 2008)
    584. New insights into bioactivation of organic nitrates, nitrate tolerance and cross-tolerance. (PubMed id 17938848)9 Daiber A....MA1nzel T. (Clin Res Cardiol 2008)
    585. [Recent findings on nitrates: their action, bioactivation and development of tolerance]. (PubMed id 18946854)9 MA1nzel T. (Dtsch. Med. Wochenschr. 2008)
    586. Structure of daidzin, a naturally occurring anti-alcohol-addiction agent, in complex with human mitochondrial aldehyde dehydrogenase. (PubMed id 18613661)9 Lowe E.D....Keung W.M. (J. Med. Chem. 2008)
    587. Pueraria lobata (Kudzu root) hangover remedies and acetaldehyde-associated neoplasm risk. (PubMed id 17980785)9 McGregor N.R. (Alcohol 2007)
    588. Inhibition of the oxidative metabolism of 3,4-dihydroxyphenylacetaldehyde, a reactive intermediate of dopamine metabolism, by 4-hydroxy-2-nonenal. (PubMed id 16956664)9 Florang V.R....Doorn J.A. (Neurotoxicology 2007)
    589. Acetaldehyde, polymorphisms and the cardiovascular system. (PubMed id 17590986)9 Yin S.J. and Peng G.S. (Novartis Found. Symp. 2007)
    590. Alcohol and airways function in health and disease. (PubMed id 17764883)9 Sisson J.H. (Alcohol 2007)
    591. Mechanistic implications of the cysteine-nicotinamide adduct in aldehyde dehydrogenase based on quantum mechanical/molecular mechanical simulations. (PubMed id 17655326)9 Wymore T....Hempel J. (Biochemistry 2007)
    592. Ascertainment bias and the pattern of nucleotide diversity at the human ALDH2 locus in a Japanese population. (PubMed id 17225965)9 Brown B.T....Wilder J.A. (J. Mol. Evol. 2007)
    593. Removal of acetaldehyde from the body. (PubMed id 17590985)9 Deitrich R.A....Vasiliou V. (Novartis Found. Symp. 2007)
    594. Oxidative inhibition of the mitochondrial aldehyde dehydrogenase promotes nitroglycerin tolerance in human blood vessels. (PubMed id 18061070)9 Hink U....Munzel T. (J. Am. Coll. Cardiol. 2007)
    595. ALDH2, ADH1B, and ADH1C genotypes in Asians: a literature review. (PubMed id 17718397)9 Eng M.Y....Wall T.L. (amp 2007)
    596. Genetic polymorphisms and esophageal cancer risk. (PubMed id 17674367)9 Hiyama T....Chayama K. (Int. J. Cancer 2007)
    597. Structural and functional consequences of coenzyme binding to the inactive asian variant of mitochondrial aldehyde dehydrogenase: roles of residues 475 and 487. (PubMed id 17327228)9 Larson H.N....Hurley T.D. (J. Biol. Chem. 2007)
    598. Helicobacter pylori, chronic atrophic gastritis, inactive aldehyde dehydrogenase-2, macrocytosis and multiple upper aerodigestive tract cancers and the risk for gastric cancer in alcoholic Japanese men. (PubMed id 17295873)9 Yokoyama A....Hibi T. (J. Gastroenterol. Hepatol. 2007)
    599. Effects of acetaldehyde on human airway constriction and inflammation. (PubMed id 17590989)9 Matsuse H....Kohno S. (Novartis Found. Symp. 2007)
    600. The determination of acetaldehyde in exhaled breath. (PubMed id 17590991)9 Tardif R. (Novartis Found. Symp. 2007)
    601. The genetics of alcohol metabolism: role of alcohol dehydrogenase and aldehyde dehydrogenase variants. (PubMed id 17718394)9 Edenberg H.J. (amp 2007)
    602. Differential actions of the proneural genes encoding Mash1 and neurogenins in Nurr1-induced dopamine neuron differentiation. (PubMed id 16723737)9 Park C.H....Lee S.H. (J. Cell. Sci. 2006)
    603. Dysfunction of mitochondria and oxidative stress in the pathogenesis of Alzheimer's disease: on defects in the cytochrome c oxidase complex and aldehyde detoxification. (PubMed id 16873963)9 Ohta S. and Ohsawa I. (J. Alzheimers Dis. 2006)
    604. Mechanisms of alcohol-induced hepatic fibrosis: a summary of the Ron Thurman Symposium. (PubMed id 16502397)9 Purohit V. and Brenner D.A. (Hepatology 2006)
    605. Complex I dysfunction and tolerance to nitroglycerin: an approach based on mitochondrial-targeted antioxidants. (PubMed id 17053193)9 Esplugues J.V....Victor V.M. (Circ. Res. 2006)
    606. Inhibition of human mitochondrial aldehyde dehydrogenase by 4-hydroxynon-2-enal and 4-oxonon-2-enal. (PubMed id 16411662)9 Doorn J.A....Petersen D.R. (Chem. Res. Toxicol. 2006)
    607. Identification of human liver mitochondrial aldehyde dehydrogenase as a potential target for microcystin-LR. (PubMed id 16413648)9 Chen T....Shen P. (Toxicology 2006)
    608. Evaluation in vinyl chloride monomer-exposed workers and the relationship between liver lesions and gene polymorphisms of metabolic enzymes. (PubMed id 16270392)9 Zhu S.M....Xia Z.L. (World J. Gastroenterol. 2005)
    609. Hydralazine is a powerful inhibitor of peroxynitrite formation as a possible explanation for its beneficial effects on prognosis in patients with congestive heart failure. (PubMed id 16289107)9 Daiber A....Tsilimingas N. (Biochem. Biophys. Res. Commun. 2005)
    610. Differential effects of Mg2+ ions on the individual kinetic steps of human cytosolic and mitochondrial aldehyde dehydrogenases. (PubMed id 15924421)9 Ho K.K....Weiner H. (Biochemistry 2005)
    611. Epidemiological evidence that acetaldehyde plays a significant role in the development of decreased serum folate concentration and elevated mean corpuscular volume in alcohol drinkers. (PubMed id 15834228)9 Yokoyama T....Tanaka H. (Alcohol. Clin. Exp. Res. 2005)
    612. Ebrii gignunt ebrios--One drunkard begets another: the genetics of alcohol dependence. (PubMed id 15802091)9 Ball D. (Curr Psychiatry Rep 2005)
    613. Overview of the role of alcohol dehydrogenase and aldehyde dehydrogenase and their variants in the genesis of alcohol-related pathology. (PubMed id 15099407)9 Crabb D.W....You M. (Proc Nutr Soc 2004)
    614. Biological and behavioral markers of alcohol sensitivity. (PubMed id 15112932)9 Fromme K....Goldman D. (Alcohol. Clin. Exp. Res. 2004)
    615. [Aldehyde dehydrogenase (ALDH2) polymorphism and drinking behavior]. (PubMed id 15639999)9 Luo H.R. and Zhang Y.P. (Yi Chuan 2004)
    616. Differential responses of serum gamma-glutamyltransferase to alcohol intake in Japanese males. (PubMed id 14627068)9 Matsuka Y....Kira S. (Acta Med. Okayama 2003)
    617. Evaluation of a microarray for genotyping polymorphisms related to xenobiotic metabolism and DNA repair. (PubMed id 14579748)9 Landi S....Canzian F. (BioTechniques 2003)
    618. Purification and characterization of two distinct aldehyde-oxidizing enzymes from the liver of black seabream. (PubMed id 12604200)9 Fong W.P....Tang W.K. (Chem. Biol. Interact. 2003)
    619. Inactivation of betaine aldehyde dehydrogenase from Pseudomonas aeruginosa and Amaranthus hypochondriacus L. leaves by disulfiram. (PubMed id 12604199)9 Velasco-GarcA-a R....MuA+oz-Clares R.A. (Chem. Biol. Interact. 2003)
    620. Species variations in cutaneous alcohol dehydrogenases and aldehyde dehydrogenases may impact on toxicological assessments of alcohols and aldehydes. (PubMed id 12499113)9 Cheung C....Smith Pease C.K. (Toxicology 2003)
    621. The ADH3*2 and CYP2E1 c2 alleles increase the risk of alcoholism in Mexican American men. (PubMed id 12710951)9 Konishi T....Wan Y.J. (Exp. Mol. Pathol. 2003)
    622. Synthesis of daidzin analogues as potential agents for alcohol abuse. (PubMed id 12927869)9 Gao G.Y....Keung W.M. (amp 2003)
    623. Population distribution of aldehyde dehydrogenase-2 genetic polymorphism: implications for risk assessment. (PubMed id 12473414)9 Ginsberg G....Sonawane B. (Regul. Toxicol. Pharmacol. 2002)
    624. Why can't Chinese Han drink alcohol? Hepatitis B virus infection and the evolution of acetaldehyde dehydrogenase deficiency. (PubMed id 12208210)9 Lin Y.P. and Cheng T.J. (Med. Hypotheses 2002)
    625. The effects of low Km aldehyde dehydrogenase (ALDH2) phenotype on drinking behavior in Japanese university students. (PubMed id 12380847)9 Sobue I....Morimoto K. (J. Stud. Alcohol 2002)
    626. Alcohol and retinoids. (PubMed id 11391073)9 Crabb D.W....Bode C. (Alcohol. Clin. Exp. Res. 2001)
    627. ADH2 and alcohol-related phenotypes in Ashkenazic Jewish American college students. (PubMed id 11545539)9 Shea S.H....Li T.K. (Behav. Genet. 2001)
    628. Genetic dissection of retinoid dehydrogenases. (PubMed id 11306068)9 Duester G. (Chem. Biol. Interact. 2001)
    629. Order and disorder in mitochondrial aldehyde dehydrogenase. (PubMed id 11306026)9 Hurley T.D....Breen H. (Chem. Biol. Interact. 2001)
    630. Alcohol and cancer. (PubMed id 11391063)9 Seitz H.K....Wang X.D. (Alcohol. Clin. Exp. Res. 2001)
    631. The ALDH2 genotype, alcohol intake, and liver-function biomarkers among Japanese male workers. (PubMed id 10942105)9 Takeshita T....Morimoto K. (Hum. Genet. 2000)
    632. Polymorphisms of human aldehyde dehydrogenases. Consequences for drug metabolism and disease. (PubMed id 10971205)9 Vasiliou V. and Pappa A. (Pharmacology 2000)
    633. Deficiency in mitochondrial aldehyde dehydrogenase increases the risk for late-onset Alzheimer's disease in the Japanese population. (PubMed id 10873585)9 Kamino K....Ohta S. (Biochem. Biophys. Res. Commun. 2000)
    634. Genetic polymorphism of enzymes involved in xenobiotic metabolism and the risk of colorectal cancer. (PubMed id 11059519)9 Kiyohara C. (J Epidemiol 2000)
    635. Accumulation of hemoglobin-associated acetaldehyde with habitual alcohol drinking in the atypical ALDH2 genotype. (PubMed id 10656185)9 Takeshita T. and Morimoto K. (Alcohol. Clin. Exp. Res. 2000)
    636. Cooperativity in nicotinamide adenine dinucleotide binding induced by mutations of arginine 475 located at the subunit interface in the human liver mitochondrial class 2 aldehyde dehydrogenase. (PubMed id 10819999)9 Wei B....Weiner H. (Biochemistry 2000)
    637. [Biomarkers of gentotoxic risk and metabolic polymorphism]. (PubMed id 11189784)9 Pavanello S. and Clonfero E. (Med Lav 2000)
    638. Metabolism of retinaldehyde and other aldehydes in soluble extracts of human liver and kidney. (PubMed id 10559215)9 Ambroziak W....Pietruszko R. (J. Biol. Chem. 1999)
    639. Blood and urinary levels of ethanol, acetaldehyde, and C4 compounds such as diacetyl, acetoin, and 2,3-butanediol in normal male students after ethanol ingestion. (PubMed id 10064379)9 Otsuka M....Ohmori S. (Alcohol 1999)
    640. Evidence for ethanol oxidation by Kupffer cells. (PubMed id 10235287)9 Nakamura Y....Ishii H. (Alcohol. Clin. Exp. Res. 1999)
    641. An examination of ALDH2 genotypes, alcohol metabolism and the flushing response in Native Americans. (PubMed id 10091951)9 Gill K....Deitrich R.A. (J. Stud. Alcohol 1999)
    642. Evaluation of the self-rating of the effects of alcohol form in Asian Americans with aldehyde dehydrogenase polymorphisms. (PubMed id 10606490)9 Wall T.L....Schuckit M.A. (J. Stud. Alcohol 1999)
    643. Activity of the human aldehyde dehydrogenase 2 promoter is influenced by the balance between activation by hepatocyte nuclear factor 4 and repression by perosixome proliferator activated receptor delta, chicken ovalbumin upstream promoter-transcription factor, and apolipoprotein regulatory protein-1. (PubMed id 10352676)9 Pinaire J....Crabb D. (Adv. Exp. Med. Biol. 1999)
    644. Genetic polymorphisms of tobacco- and alcohol-related metabolizing enzymes and oral cavity cancer. (PubMed id 10521794)9 Katoh T....Kawamoto T. (Int. J. Cancer 1999)
    645. Genotype difference of aldehyde dehydrogenase 2 gene in alcohol drinkers influences the incidence of Japanese colorectal cancer patients. (PubMed id 10470282)9 Murata M....Morimoto K. (Jpn. J. Cancer Res. 1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 217 HGNC: 404 AceView: ALDH2andACAD10 Ensembl:ENSG00000111275 euGenes: HUgn217
    ECgene: ALDH2 Kegg: 217 H-InvDB: ALDH2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for ALDH2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ALDH2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for ALDH2 gene:
    Search GeneIP for patents involving ALDH2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for ALDH2   OriGene RNAi products in human, mouse, rat for ALDH2  
     OriGene qPCR primer pairs and template standards for ALDH2   OriGene Protein Over-expression Lysate for ALDH2  
     OriGene MassSpec something-or-other for ALDH2   OriGene clones in human, mouse for ALDH2  
     OriGene qSTAR qPCR primer pairs in human, mouse for ALDH2   OriGene Purified Protein for ALDH2  
     OriGene ORF clones in mouse, rat for ALDH2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ALDH2   OriGene Custom Protein Services for ALDH2  

     
     
     Block miRNA regulation of human, mouse, rat ALDH2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing ALDH2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ALDH2 Predesigned siRNA for gene silencing in human, mouse, rat ALDH2
     QuantiFast Probe-based Assays in human, mouse, rat ALDH2 QuantiTect SYBR Green Assays in human, mouse, rat ALDH2
     PCR Arrays including human, mouse, rat ALDH2 Search Chromatin IP Primers for ALDH2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ALDH2  GeneGlobe Interaction Network for ALDH2
     Regulatory tfbs in ALDH2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for ALDH2 GenScript cDNA clones with any tag delivered in your preferred vector for ALDH2
     GenScript Custom Assay Services for ALDH2 GenScript Custom overexpressing Cell Line Services for ALDH2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Tocris compounds for ALDH2
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for ALDH2
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     ALDH2 antibodies
     ALDH2 proteins
     ALDH2 lysates
     Antibodies for ALDH2
     See all of Abcam's Antibodies, Kits and Proteins for ALDH2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for ALDH2
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for ALDH2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALDH2
     SwitchGear 3'UTR luciferase reporter plasmids for ALDH2
     SwitchGear Promoter luciferase reporter plasmids for ALDH2
     ThermoFisher Antibody for ALDH2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALDH2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ALDH2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ALDH2
     LSBio Antibodies in human, mouse, rat for ALDH2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ALDH2 gene at Home site.
    Version: 3.12.166 28 Aug 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4