ALDH2 Gene

Aliases
for ALDH2 gene

Previous GC identifers: GC12P111101 GC12P111726 GC12P111987 GC12P110616 GC12P110667 GC12P109217

Summaries
for ALDH2 gene

Genomic Views
for ALDH2 gene

RefSeq DNA sequence:

NC_000012.11  NC_018923.1  NT_009775.17  

SwitchGear Promoter luciferase reporter plasmids (see all 2): ALDH2 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ALDH2

ALDH2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P112205:  view genomic region     (about GC identifiers)

Proteins
for ALDH2 gene

6/24 PDB 3D structures from and Proteopedia for ALDH2 (see all 24):

1CW3 (3D)        1NZW (3D)        1NZX (3D)        1NZZ (3D)        1O00 (3D)        1O01 (3D)    

Explore the universe of human proteins at neXtProt for ALDH2: NX_P05091

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	OriGene Purified Protein: ALDH2 OriGene Protein Over-expression Lysate: ALDH2 OriGene Custom Protein Services for ALDH2
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	Novus Biologicals ALDH2 Proteins Novus Biologicals ALDH2 Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for ALDH2
	Uscn Proteins for ALDH2

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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	OriGene Antibodies (see all 5): ALDH2 OriGene Custom Antibody Services for ALDH2
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	ThermoFisher Antibodies for ALDH2

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	Uscn ELISAs and CLIAs for ALDH2

Protein Domains /
Families
for ALDH2 gene

ProtoNet protein and cluster: P05091

Function
for ALDH2 gene

     Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

(inferred from 3 alleles) (MGI details for Aldh2)

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ALDH2

miRNA Products:		OriGene 3'-UTR Clone: ALDH2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ALDH2
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		SwitchGear 3'UTR luciferase reporter plasmid: ALDH2 3' UTR sequence

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		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ALDH2 (see all 7) OriGene shRNA RFP: ALDH2 OriGene siRNA: ALDH2
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			Sirion Biotech Customized adenovirus for overexpression of ALDH2  Sirion Biotech Customized adenovirus for potent knockdown of ALDH2

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		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ALDH2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ALDH2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALDH2

Pathways & Interactions
for ALDH2 gene

	Super-pathway	contained gene-specific pathways
1	Monoamines are oxidized to aldehydes by MAOA and MAOB, producing NH3 and H2O2	Serotonin clearance from the synaptic cleft 0.33 putrescine degradation III 0.20 Metabolism of serotonin 0.33 Ifosfamide Pathway, Pharmacodynamics 0.00 phenylalanine degradation IV (mammalian, via side chain) 0.29
2	Ethanol oxidation	Ethanol oxidation 1.00 Cyclophosphamide Pathway, Pharmacodynamics 0.42 Fatty Acid Omega Oxidation 0.47
3	ethanol degradation II	ethanol degradation II 1.00 ethanol degradation IV 0.57 oxidative ethanol degradation III 0.57
4	Retinol metabolism	Retinol metabolism 1.00 Retinol metabolism 0.95
5	Transmission across Chemical Synapses	Transmission across Chemical Synapses 1.00 Neuronal System 0.67

1 EMD Millipore Pathway for ALDH2

Retinol metabolism

1 GeneGo (Thomson Reuters) Pathway for ALDH2

Retinol metabolism

5/10 BioSystems Pathways for ALDH2

	phenylalanine degradation IV (mammalian, via side chain)
	ethanol degradation IV
	serotonin degradation
	putrescine degradation III
	ethanol degradation II

5/9        Reactome Pathways for ALDH2

	Metabolism of serotonin
	Serotonin clearance from the synaptic cleft
	Transmission across Chemical Synapses
	Metabolism
	Neuronal System

2 PharmGKB Pathways for ALDH2

	Cyclophosphamide Pathway, Pharmacodynamics
	Ifosfamide Pathway, Pharmacodynamics

5/14         Kegg Pathways  (Kegg details for ALDH2)

	Glycolysis / Gluconeogenesis
	Pentose and glucuronate interconversions
	Ascorbate and aldarate metabolism
	Fatty acid metabolism
	Valine, leucine and isoleucine degradation

ALDH2 for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for ALDH2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/305 Interacting proteins for ALDH2 (P05091^{2, 3} ENSP00000261733⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 305)

Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

Drugs & Compounds
for ALDH2 gene

Transcripts
for ALDH2 gene

Expression
for ALDH2 gene

ALDH2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGGGTTGGC

About this image

ALDH2 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells
	Tissue Anatomical Compartment Cell			Category (developmental path)
	BrainBlood Brain BarrierAdult Endothelial Cells			Blood Brain Barrier, Endothelium
	Head MesenchymeBranchial Arch 1Cranial Neural Crest Cells			Neural Crest
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 1 LifeMap Cell
	Name			Category
	N2/LSB induced-cells (Generation of midbra...)

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ALDH2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ALDH2
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In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALDH2

Orthologs
for ALDH2 gene

Paralogs
for ALDH2 gene

Paralogs for ALDH2 gene

ALDH1L2²  ALDH1A1²  ENSG00000257767²  ALDH1A2²  ALDH1B1²  ALDH7A1²  ALDH16A1²  ALDH8A1²  

ALDH9A1²  ALDH1L1²  ALDH1A3²  

13 SIMAP similar genes for ALDH2 using alignment to 10 protein entries:     ALDH2_HUMAN (see all proteins):

ALDH1A2    ALDH1B1    ALDH1A1    ALDH1A3    DKFZp686G1675    ALDH1L2

ALDH1L1    ALDH9A1    ALDH8A1    ALDH5A1    ALDH6A1    ALDH7A1

ALDH3A1

ALDH2 for paralogs           About GeneDecksing

Genomic Variants
for ALDH2 gene

10/678 NCBI SNPs in ALDH2 are shown (see all 678)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs6711,2	C,F,H	drug-response	109255106(+)	ACACTG/AAAGTG	4	/K /E	mis1 ese3		26		MN CA NS EA NA	2426
rs557371281,2	C	--	109216340(+)	GCCTCA/GCCTTC	2	--	us2k1		2		WA	120
rs779807651,2	C,F	--	109217096(+)	GAAGTG/AGGGCC	2	--	us2k1		1		WA	118
rs71368901,2	A	--	109217542(+)	gcaggC/Tgcctg	2	--	us2k1		0	--	--	--	--
rs758120271,2	C	--	109217847(+)	CCTGGC/TCTTTG	2	--	us2k1		2		WA	120
rs64903011,2	C,A	--	109218393(+)	TTGCGC/TGCTGC	4	R	syn1 ese3		0	--	--	--	--
rs120995901,2	C	--	109219142(+)	GTGGTC/GCATTT	2	--	int1		2		WA	120
rs778191451,2	C	--	109219239(+)	AATTGG/ATTATG	2	--	int1		2		WA	120
rs1168188401,2	C,F	--	109219401(+)	CTGCAC/TAGCCT	2	--	int1		1		WA	118
rs751620231,2	C,F	--	109219657(+)	ACCACC/TGATCC	2	--	int1		1		EA	120

HapMap Linkage Disequilibrium report for ALDH2 (112204346 - 112247784 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for ALDH2: --
Human Gene Mutation Database (HGMD): ALDH2

Locus Specific Mutation Databases (LSDB): ALDH2

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ALDH2

DNA2.0 Custom Variant and Variant Library Synthesis for ALDH2

Disorders / Diseases
for ALDH2 gene

20/87 diseases for ALDH2

10/56 Novoseek disease relationships for ALDH2 gene (see all 56)    About this table

Publications
for ALDH2 gene

PubMed articles for ALDH2 gene, integrated from 9 sources (see all 658) (see top 10): (articles sorted by number of sources associating them with ALDH2)

Utopia: connect your pdf to the dynamic world of online information

1. Cloning of cDNAs for human aldehyde dehydrogenases 1 and 2. (PubMed id 2987944)^{1, 2, 3} Hsu L.C.... Yoshida A. (1985)
2. Molecular abnormality and cDNA cloning of human aldehyde dehydrogenases. (PubMed id 4015823)^{1, 2, 3} Yoshida A.... Tani K. (1985)
3. Aldehyde dehydrogenase 2 and beta3-adrenergic receptor gene polymorphisms: their association with elevated liver enzymes and metabolic syndrome. (PubMed id 14506613)^{1, 4, 9} Murata C....Okazaki I. (2003)
4. ALDH2 and CYP2E1 genotypes, urinary acetaldehyde excretion and the health consequences in moderate alcohol consumers. (PubMed id 16365683)^{1, 4, 9} Yamada Y....Honda R. (2006)
5. [Effects of genetic polymorphisms of ethanol-metabolizing enzymes on alcohol drinking behaviors] (PubMed id 12824748)^{1, 4, 9} Kee J.Y....Chae H.B. (2003)
6. [Polymorphism of alcohol metabolizing-related enzyme genes and its correlation with drinking-behaviors in 201 cases of Chinese Han healthy population.] (PubMed id 15842823)^{1, 4, 9} Cao X.R. and Wu D.S. (2005)
7. Genetic polymorphisms of aldehyde dehydrogenase 2, cytochrome p450 2E1 for liver cancer risk in HCV antibody-positive japanese patients and the variations of CYP2E1 mRNA expression levels in the liver due to its polymorphism. (PubMed id 12940444)^{1, 4, 9} Kato S....Naito Z. (2003)
8. Effects of ALDH2 gene polymorphisms and alcohol-drinking behavior on micronuclei frequency in non-smokers. (PubMed id 14568296)^{1, 4, 9} Ishikawa H....Yokoyama K. (2003)
9. Effects of dietary intake and genetic factors on hypermethylation of the hMLH1 gene promoter in gastric cancer. (PubMed id 15991278)^{1, 4, 9} Nan H.M....Kim H. (2005)
10. Alcohol and aldehyde dehydrogenase polymorphisms in men with type I and Type II alcoholism. (PubMed id 15863807)^{1, 4, 9} Chai Y.G....Choi I.G. (2005)
11. Alcohol dehydrogenase-2 and aldehyde dehydrogenase-2 genotypes and male alcohol use disorders in Khon Kaen, north-east Thailand. (PubMed id 12519453)^{1, 4, 9} Osaka R....Fukuda K. (2003)
12. A case-control study of association between life-style, alcohol dehydrogenase 2 and aldehyde dehydrogenase 2 genotype and idiopathic osteonecrosis of the femoral head. (PubMed id 14768474)^{1, 4, 9} Sakata R. (2003)
13. [Compare of distributions of gene polymorphisms about alcohol metabolizing-related enzymes in five Chinese nationalities] (PubMed id 12545748)^{1, 4, 9} Cao X. and Wu D. (2002)
14. Chinese alcoholic patients with esophageal cancer are genetically different from alcoholics with acute pancreatitis and liver cirrhosis. (PubMed id 11051375)^{1, 4, 9} Chao Y.C....Chu H.C. (2000)
15. Alcohol and aldehyde dehydrogenase polymorphisms in Japanese patients with alcohol-induced chronic pancreatitis. (PubMed id 11117576)^{1, 4, 9} Kimura S....Kasuga M. (2000)
16. A gene-gene interaction between ALDH2 Glu487Lys and ADH2 His47Arg polymorphisms regarding the risk of colorectal cancer in Japan. (PubMed id 16332725)^{1, 4, 9} Matsuo K....Tajima K. (2006)
17. Genetic polymorphisms of alcohol and aldehyde dehydrogenase, dopamine and serotonin transporters in familial and non-familial alcoholism. (PubMed id 16125912)^{1, 4, 9} Choi I.G....Shin H.D. (2006)
18. [Genetic susceptibility to the development of acute alcoholic hepatitis: role of genetic mutations in dehydrogenase alcohol, aldehyde dehydrogenase and cytochrome P450 2E1] (PubMed id 16324524)^{1, 4, 9} Segado Soriano A....Gomez-Gallego F. (2005)
19. Relation of the CD36 gene A52C polymorphism to the risk of colorectal cancer among Japanese, with reference to with the aldehyde dehydrogenase 2 gene Glu487Lys polymorphism and drinking habit. (PubMed id 15780035)^{1, 4, 9} Kuriki K....Tajima K. (2005)
20. [Alcohol-induced arterial hypertension and genetic polymorphism of alcohol-metabolizing enzymes] (PubMed id 16078602)^{1, 4, 9} Moiseev V.S....Shipulin G.A. (2005)
21. Association of habitual smoking and drinking with single nucleotide polymorphism (SNP) in 40 candidate genes: data from random population-based Japanese samples. (PubMed id 15654505)^{1, 4, 9} Liu Y....Tsugane S. (2005)
22. A comprehensive analysis of phase I and phase II metabolism gene polymorphisms and risk of colorectal cancer. (PubMed id 16006997)^{1, 4, 9} Landi S....Canzian F. (2005)
23. [Genetic polymorphisms of alcohol-metabolizing enzymes and cytokines in patients with alcohol induced pancreatitis and alcoholic liver cirrhosis] (PubMed id 15220553)^{1, 4, 9} Kim M.S....Lee M.S. (2004)
24. ADH1B*1, ADH1C*2, DRD2 (-141C Ins), and 5-HTTLPR are associated with alcoholism in Mexican American men living in Los Angeles. (PubMed id 15318112)^{1, 4, 9} Konishi T....Wan Y.J. (2004)
25. Possible interaction of alcohol dehydrogenase and aldehyde dehydrogenase genes with the dopamine D2 receptor gene in anxiety-depressive alcohol dependence. (PubMed id 15084894)^{1, 4, 9} Huang S.Y....Lu R.B. (2004)
26. Genotype announcement in a genetic polymorphism study for health checkup examinees at Nagoya University Hospital. (PubMed id 15279067)^{1, 4, 9} Nishio K....Hamajima N. (2004)
27. [Gene-environmental interactions in alcohol-related health problems--contributions of molecular biology to behavior modifications] (PubMed id 12806963)^{1, 4, 9} Takeshita T. (2003)
28. [Studies of genetic polymorphisms of ADH2 and ALDH2 among the Han population in Luoyang China] (PubMed id 16135443)^{1, 4, 9} Zhang Z.M....Shen F.M. (2002)
29. Alcohol sensitivity in Taiwanese men with different alcohol and aldehyde dehydrogenase genotypes. (PubMed id 12517056)^{1, 4, 9} Peng G.S....Yin S.J. (2002)
30. Association between aldehyde dehydrogenase gene polymorphisms and the phenomenon of field cancerization in patients with head and neck cancer. (PubMed id 12376487)^{1, 4, 9} Muto M....Esumi H. (2002)
31. Association between polymorphisms of ethanol-metabolizing enzymes and susceptibility to alcoholic cirrhosis in a Korean male population. (PubMed id 11748356)^{1, 4, 9} Lee H.C....Kim C.Y. (2001)
32. Association of polymorphism in the alcohol dehydrogenase 2 gene with alcohol-induced testicular atrophy. (PubMed id 11410735)^{1, 4, 9} Yamauchi M....Toda G. (2001)
33. Molecular epidemiology of preterm delivery: methodology and challenges. (PubMed id 11520401)^{1, 4, 9} Wang X....Xu X. (2001)
34. Alcoholism, ALDH2*2 allele and the A1 allele of the dopamine D2 receptor gene: an association study. (PubMed id 11600186)^{1, 4, 9} Matsushita S....Higuchi S. (2001)
35. Testing genetic susceptibility loci for alcoholic heart muscle disease. (PubMed id 11696658)^{1, 4, 9} Kajander O.A....Karhunen P.J. (2001)
36. Alcohol and aldehyde dehydrogenase gene polymorphisms and oropharyngolaryngeal, esophageal and stomach cancers in Japanese alcoholics. (PubMed id 11238183)^{1, 4, 9} Yokoyama A....Ishii H. (2001)
37. Alcohol, ALDH2, and esophageal cancer: a meta-analysis which illustrates the potentials and limitations of a Mendelian randomization approach. (PubMed id 16103445)^{1, 4} Lewis S.J. and Smith G.D. (2005)
38. Folate, vitamin B6, vitamin B12, and vitamin B2 intake, genetic polymorphisms of related enzymes, and risk of colorectal cancer in a hospital-based case-control study in Japan. (PubMed id 16351505)^{1, 4} Otani T....Tsugane S. (2005)
39. Alcohol drinking frequency is more directly associated with alcohol use disorder than alcohol metabolizing enzymes among male Japanese. (PubMed id 15679538)^{1, 4} Nishiyori A....Fukuda K. (2005)
40. Genetic polymorphisms of CYP2E1, GSTT1, GSTP1, GSTM1, ALDH2, and ODC and the risk of advanced precancerous gastric lesions in a Chinese population. (PubMed id 15734972)^{1, 4} You W.C....Gail M.H. (2005)
41. Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes. (PubMed id 15242332)^{1, 2} Aboulaich N.... Vener A.V. (2004)
42. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
43. Genetic polymorphisms in three Iranian populations with different risks of esophageal cancer, an ecologic comparison. (PubMed id 15327835)^{1, 4} Sepehr A....Dawsey S.M. (2004)
44. Genetic analysis of 22 candidate genes for hypertension in the Japanese population. (PubMed id 15167446)^{1, 4} Iwai N....Shioji K. (2004)
45. Alcohol flushing, alcohol and aldehyde dehydrogenase genotypes, and risk for esophageal squamous cell carcinoma in Japanese men. (PubMed id 14652286)^{1, 4} Yokoyama T....Yoshimizu H. (2003)
46. Allelic variation at alcohol metabolism genes ( ADH1B, ADH1C, ALDH2) and alcohol dependence in an American Indian population. (PubMed id 12884000)^{1, 4} Mulligan C.J....Long J.C. (2003)
47. [Relationship between ALDH gene polymorphism and alcoholic liver diseases] (PubMed id 14636437)^{1, 4} Yan M....Wu M.L. (2003)
48. Age-dependent changes in electroencephalographic responses to alcohol consumption in subjects with aldehyde dehydrogenase-2 genetic variations. (PubMed id 12766630)^{1, 4} Nishimura F.T....Nishijo H. (2003)
49. Alcohol dependence symptoms and alcohol dehydrogenase 2 polymorphism: Israeli Ashkenazis, Sephardics, and recent Russian immigrants. (PubMed id 12351924)^{1, 4} Hasin D....Li T.K. (2002)
50. Polymorphism of the neuropeptide Y gene: an association study with alcohol withdrawal. (PubMed id 11410744)^{1, 4} Okubo T. and Harada S. (2001)
51. Human liver mitochondrial aldehyde dehydrogenase: three-dimensional structure and the restoration of solubility and activity of chimeric forms. (PubMed id 10631996)^{1, 2} Ni L.... Weiner H. (1999)
52. Mitochondrial aldehyde dehydrogenase polymorphism in Asian and American Indian populations: detection of new ALDH2 alleles. (PubMed id 8561277)^{1, 2} Novoradovsky A....Goldman D. (1995)
53. Genomic structure of the human mitochondrial aldehyde dehydrogenase gene. (PubMed id 2838413)^{1, 2} Hsu L.C.... Yoshida A. (1988)
54. Mitochondrial aldehyde dehydrogenase. Homology of putative targeting sequence to that of carbamyl phosphate synthetase I revealed by correlation of cDNA and protein data. (PubMed id 3653404)^{1, 2} Hempel J.... Joernvall H. (1987)
55. Human aldehyde dehydrogenase isozymes and alcohol sensitivity. (PubMed id 3610592)^{1, 2} Agarwal D.P. and Goedde H.W. (1987)
56. Evidence for a signal peptide at the amino-terminal end of human mitochondrial aldehyde dehydrogenase. (PubMed id 3582651)^{1, 2} Braun T.... Goedde H.W. (1987)
57. Isolation and sequence analysis of a full length cDNA clone coding for human mitochondrial aldehyde dehydrogenase. (PubMed id 3562250)^{1, 2} Braun T.... Goedde H.W. (1987)
58. Mitochondrial aldehyde dehydrogenase from human liver. Primary structure, differences in relation to the cytosolic enzyme, and functional correlations. (PubMed id 4065146)^{1, 2} Hempel J.... Joernvall H. (1985)
59. Molecular abnormality of an inactive aldehyde dehydrogenase variant commonly found in Orientals. (PubMed id 6582480)^{1, 2} Yoshida A.... Ikawa M. (1984)
60. Meta-analysis of three diabetes population studies: association of inactive ALDH2 genotype with maternal inheritance of diabetes. (PubMed id 15563966)^{1, 9} Murata C....Suzuki Y. (2004)
61. Association between personality traits and ALDH2 polymorphism in Japanese male alcoholics. (PubMed id 19298328)^{1, 9} Kimura M....Kashima H. (2009)
62. Genetic association between aldehyde dehydrogenase 2 (ALDH2) variation and high-density lipoprotein cholesterol (HDL-C) among non-drinkers in two large population samples in Japan. (PubMed id 18776700)^{1, 9} Wada M....Kato T. (2008)
63. Aldehyde dehydrogenase-2 genotypes and HLA haplotypes in Japanese patients with esophageal cancer. (PubMed id 12168074)^{1, 9} Watanabe S....Kuriyama S. (2002)
64. Salivary Acetaldehyde Concentration According to Alcoholic Beverage Consumed and Aldehyde Dehydrogenase-2 Genotype. (PubMed id 18616675)^{1, 9} Yokoyama A....Yokoyama T. (2008)
65. Aldehyde dehydrogenase 2 in cardiac protection: a new therapeutic target? (PubMed id 20005475)^{1, 9} Budas G.R....Mochly-Rosen D. (2009)
66. Genetic polymorphisms in cytochrome P4502E1, alcohol and aldehyde dehydrogenases and the risk of esophageal squamous cell carcinoma in Gansu Chinese males. (PubMed id 18322963)^{1, 9} Guo Y.M....Guo Q.H. (2008)
67. Interactive effects of lifetime alcohol consumption and alcohol and aldehyde dehydrogenase polymorphisms on esophageal cancer risks. (PubMed id 17036331)^{1, 9} Chen Y.J....Wu M.T. (2006)
68. Esophageal squamous cell carcinoma and aldehyde dehydrogenase-2 genotypes in Japanese females. (PubMed id 16499490)^{1, 9} Yokoyama A....Watanabe H. (2006)
69. Chaperonin GroESL mediates the protein folding of human liver mitochondrial aldehyde dehydrogenase in Escherichia coli. (PubMed id 12387818)^{1, 9} Lee K.H....Lee Y.S. (2002)
70. Gene-environment interaction between an aldehyde dehydrogenase-2 (ALDH2) polymorphism and alcohol consumption for the risk of esophageal cancer. (PubMed id 11375898)^{1, 9} Matsuo K....Tajima K. (2001)
71. [Aldehyde dehydrogenase 2(ALDH2) gene polymorphism in NIDDM patients with chronic renal failure] (PubMed id 9752691)^{4, 9} Kuriyama S....Hosoya T. (1998)
72. Dominance of the mutant ALDH2(2) allele in the expression of human stomach aldehyde dehydrogenase-2 activity. (PubMed id 8290656)^{1, 9} Chao Y.C....Yin S.J. (1993)
73. Absence of association on aldehyde dehydrogenase 2 (A LDH2) polymorphism with Mongolian Alzheimer patients. (PubMed id 19914339)^{1, 9} Zhou S....Ma X. (2010)
74. [Association between aldehyde dehydrogenase-2/cytochr ome P450 2E1 genetic polymorphism and habit of alcohol drinking and the suscept ibility of hepatocellular carcinoma] (PubMed id 20364586)^{1, 9} Ye X....Li L. (2010)
75. MAOA-uVNTR polymorphism may modify the protective effect of ALDH2 gene against alcohol dependence in antisocial personality disorder. (PubMed id 19302089)^{1, 9} Lee S.Y....Lu R.B. (2009)
76. Associations of ALDH2 and ADH1B genotypes with alcohol-related phenotypes in Asian young adults. (PubMed id 19298323)^{1, 9} Hendershot C.S....Larimer M.E. (2009)
77. Association of ALDH2 polymorphism with sensitivity to acetaldehyde-induced micronuclei and facial flushing after alcohol intake. (PubMed id 15840430)^{1, 9} Kim J.S....Chung H.W. (2005)
78. Inactive aldehyde dehydrogenase-2 increased the risk of pancreatic cancer among smokers in a Japanese male population. (PubMed id 15714130)^{1, 9} Miyasaka K....Funakoshi A. (2005)
79. Aldehyde dehydrogenase 2 plays a role in the bioactivation of nitroglycerin in humans. (PubMed id 16051882)^{7, 9} Mackenzie I.S....Wilkinson I.B. (2005)
80. Mitochondrial ALDH2 deficiency as an oxidative stress. (PubMed id 15126281)^{1, 9} Ohta S....Shimokata H. (2004)
81. ALDH2/ADH2 polymorphism associated with vasculopathy and neuropathy in type 2 diabetes. (PubMed id 15318096)^{1, 9} Suzuki Y....Matsuoka K. (2004)
82. [Genetic polymorphisms of alcohol dehydrogenase-2 and aldehyde dehydrogenase-2 associated with the susceptibility on esophageal canc er] (PubMed id 19799139)^{1, 9} Ding J.H....Yao G.H. (2009)
83. Genetic modulation of ADH1B and ALDH2 polymorphisms w ith regard to alcohol and tobacco consumption for younger aged esophageal squam ous cell carcinoma diagnosis. (PubMed id 19449376)^{1, 9} Lee C.H....Wu M.T. (2009)
84. A promoter polymorphism in the ALDH2 gene affects its basal and acetaldehyde/ethanol-induced gene expression in human peripheral blood leukocytes and HepG2 cells. (PubMed id 19144977)^{1, 9} Kimura Y....Saijoh K. (2009)
85. Influence of NQO1, ALDH2, and CYP2E1 genetic polymorphisms, smoking, and alcohol drinking on the risk of lung cancer in Koreans. (PubMed id 18798003)^{1, 9} Eom S.Y....Kim H. (2008)
86. Carcinogenetic impact of ADH1B and ALDH2 genes on squamous cell carcinoma risk of the esophagus with regard to the consumption of alcohol, tobacco and betel quid. (PubMed id 18033686)^{1, 9} Lee C.H....Wu M.T. (2008)
87. Effect of aldehyde dehydrogenase-2 genotype on cardiac autonomic nervous responses to moderate alcohol ingestion. (PubMed id 18540919)^{1, 9} Akamatsu Y....Moritani T. (2008)
88. Ethnic differences in level of response to alcohol between Chinese Americans and Korean Americans. (PubMed id 18299763)^{1, 9} Duranceaux N.C....Wall T.L. (2008)
89. Influence of ALDH2 genetic polymorphisms on aciclovir pharmacokinetics following oral administration of valaciclovir in Japanese end-stage renal disease patients. (PubMed id 18974607)^{1, 9} Hara K....Nagashima S. (2008)
90. Association of alcohol dehydrogenase 2 and aldehyde dehydrogenase 2 genotypes with fasting plasma glucose levels in Japanese male and female workers. (PubMed id 18216179)^{1, 9} Dakeishi M....Iwata T. (2008)
91. Alcohol dehydrogenase-2 and aldehyde dehydrogenase-2 genotypes, alcohol drinking and the risk of primary hepatocellular carcinoma in a chinese population. (PubMed id 18439068)^{1, 9} Ding J....Chang J. (2008)
92. Effects of variation at the ALDH2 locus on alcohol me tabolism, sensitivity, consumption, and dependence in Europeans. (PubMed id 16792555)^{1, 9} Dickson P.A....Birley A.J. (2006)
93. Gene-environmental interactions between alcohol-drinking behavior and ALDH2 and CYP2E1 polymorphisms and their impact on micronuclei frequency in human lymphocytes. (PubMed id 16126235)^{1, 9} Ishikawa H....Yokoyama K. (2006)
94. Application of aldehyde dehydrogenase 2 (ALDH2) genetic diagnosis in support of decreasing alcohol intake. (PubMed id 16788276)^{1, 9} Komiya Y....Katoh T. (2006)
95. Contribution of aldehyde dehydrogenase to mitochondrial bioactivation of nitroglycerin: evidence for the activation of purified soluble guanylate cyclase through direct formation of nitric oxide. (PubMed id 15377279)^{1, 9} Kollau A....Mayer B. (2005)
96. Molecular cloning, baculovirus expression, and tissue distribution of the zebrafish aldehyde dehydrogenase 2. (PubMed id 15703303)^{1, 9} Lassen N....Vasiliou V. (2005)
97. Relationship between genetic polymorphisms of alcohol and aldehyde dehydrogenases and esophageal squamous cell carcinoma risk in males. (PubMed id 16127737)^{1, 9} Wu C.F....Wu M.T. (2005)
98. Multiple cancers associated with esophageal and oropharyngolaryngeal squamous cell carcinoma and the aldehyde dehydrogenase-2 genotype in male Japanese drinkers. (PubMed id 12223435)^{1, 9} Yokoyama A....Tachimori Y. (2002)
99. Genetic polymorphisms of alcohol and aldehyde dehydrogenases and glutathione S-transferase M1 and drinking, smoking, and diet in Japanese men with esophageal squamous cell carcinoma. (PubMed id 12419833)^{1, 9} Yokoyama A....Yoshimizu H. (2002)
100. [Distribution of genotypes of alcohol dehydrogenase 2 and aldehyde dehydrogenase 2 in Japanese twin children] (PubMed id 11864460)^{4, 9} Qu W....Zhang Y. (1999)
101. ALDH2 genetic polymorphism and the risk of type II di abetes mellitus in CAD patients. (PubMed id 19876063)^{1, 9} Xu F....Zhang Y. (2010)
102. Role of the general base Glu-268 in nitroglycerin bio activation and superoxide formation by aldehyde dehydrogenase-2. (PubMed id 19506075)^{1, 9} Wenzl M.V....Mayer B. (2009)
103. Efficient expression of codon-adapted human acetaldeh yde dehydrogenase 2 cDNA with 6xHis tag in Pichia pastoris. (PubMed id 19911129)^{1, 9} Zhao Y....Wang C. (2009)
104. [Relationship between susceptibility of formaldehyde metabolism and genetic polymorphisms of ALDH2 and cytochrome P4502E1] (PubMed id 19115622)^{1, 9} Cheng X.M....Shao H. (2008)
105. Inhibition of aldehyde dehydrogenase type 2 attenuates vasodilatory action of nitroglycerin in human veins. (PubMed id 18272654)^{1, 9} Huellner M.W....Rau T. (2008)
106. Polymorphisms of alcohol dehydrogenase 2 and aldehyde dehydrogenase 2 and colorectal cancer risk in Chinese males. (PubMed id 18763293)^{1, 9} Gao C.M....Tajima K. (2008)
107. Roles of the genetic variation of alcohol-metabolizing enzymes on biomarkers in trauma patients with excessive alcohol intake at emergency department. (PubMed id 18078815)^{1, 9} Tseng Y.M....Lee J.H. (2008)
108. Distribution of alcohol-metabolizing enzyme genotypes in trauma patients with excessive alcohol consumption in the emergency department. (PubMed id 17292341)^{1, 9} Tseng Y.M....Tsai L.Y. (2007)
109. Susceptibility to lung cancer and genetic polymorphisms in the alcohol metabolite-related enzymes alcohol dehydrogenase 3, aldehyde dehydrogenase 2, and cytochrome P450 2E1 in the Japanese population. (PubMed id 17559142)^{1, 9} Minegishi Y....Esumi H. (2007)
110. Genetic polymorphisms of ADH2 and ALDH2 association with esophageal cancer risk in southwest China. (PubMed id 17963305)^{1, 9} Yang S.J....Yang C.X. (2007)
111. Genotoxic effects of alcohol in human peripheral lymphocytes modulated by ADH1B and ALDH2 gene polymorphisms. (PubMed id 17207821)^{1, 9} Ishikawa H....Yokoyama K. (2007)
112. Single nucleotide polymorphisms of the ALDH2 gene in six Indian populations. (PubMed id 17952709)^{1, 9} Bhaskar L.V....Rao V.R. (2007)
113. A Glu487Lys polymorphism in the gene for mitochondrial aldehyde dehydrogenase 2 is associated with myocardial infarction in elderly Korean men. (PubMed id 17459359)^{1, 9} Jo S.A....Jo I. (2007)
114. Dietary selenium intake, aldehyde dehydrogenase-2 and X-ray repair cross-complementing 1 genetic polymorphisms, and the risk of esophageal squamous cell carcinoma. (PubMed id 16639733)^{1, 9} Cai L....Zhang Z.F. (2006)
115. Esophageal cancer risk by ALDH2 and ADH2 polymorphisms and alcohol consumption: exploration of gene-environment and gene-gene interactions. (PubMed id 16235983)^{1, 9} Yang C.X....Tajima K. (2005)
116. Tissue-distribution of aldehyde dehydrogenase 2 and effects of the ALDH2 gene-disruption on the expression of enzymes involved in alcohol metabolism. (PubMed id 15569633)^{1, 9} Oyama T....Kawamoto T. (2005)
117. Mean corpuscular volume and the aldehyde dehydrogenase-2 genotype in male Japanese workers. (PubMed id 14506399)^{1, 9} Yokoyama M....Nakamura H. (2003)
118. XRCC1, CYP2E1 and ALDH2 genetic polymorphisms and sister chromatid exchange frequency alterations amongst vinyl chloride monomer-exposed polyvinyl chloride workers. (PubMed id 12739102)^{1, 9} Wong R.H....Cheng T.J. (2003)
119. Relationships between cigarette smoking, alcohol drinking, the ALDH2 genotype and adenomatous types of colorectal polyps in male self-defense force officials. (PubMed id 11210104)^{1, 9} Takeshita T....Kono S. (2000)
120. Alcohol dehydrogenase-2 and aldehyde dehydrogenase-2 genotypes, alcohol drinking and the risk for esophageal cancer in a Chinese pop ulation. (PubMed id 20010786)^{1, 9} Ding J.H....Yao G.H. (2010)
121. A novel polymorphism rs1329149 of CYP2E1 and a known polymorphism rs671 of ALDH2 of alcohol metabolizing enzymes are associated with colorectal cancer in a southwestern Chinese population. (PubMed id 19706845)^{1, 9} Yang H....Cao J. (2009)
122. Polymorphisms of alcohol dehydrogenase-2 and aldehyde dehydrogenase-2 and esophageal cancer risk in Southeast Chinese males. (PubMed id 19452585)^{1, 9} Ding J.H....Yao G.H. (2009)
123. A PBPK model for evaluating the impact of aldehyde dehydrogenase polymorphisms on comparative rat and human nasal tissue acetaldehyde dosimetry. (PubMed id 18302046)^{1, 9} Teeguarden J.G....Jarabek A.M. (2008)
124. ALDH2 promoter polymorphism has no effect on the risk for alcoholism. (PubMed id 16624836)^{1, 9} Kimura M....Higuchi S. (2006)
125. Influence of alcohol consumption and gene polymorphisms of ADH2 and ALDH2 on hepatocellular carcinoma in a Japanese population. (PubMed id 16187278)^{1, 9} Sakamoto T....Tanaka K. (2006)
126. Mitochondrial aldehyde dehydrogenase-2 (ALDH2) Glu504Lys polymorphism contributes to the variation in efficacy of sublingual nitroglycerin. (PubMed id 16440063)^{1, 9} Li Y....Jin L. (2006)
127. Rapid, accurate genotyping of alcohol dehydrogenase-1B and aldehyde dehydrogenase-2 based on the use of denaturing HPLC. (PubMed id 16309369)^{1, 9} Li L....Xu X.M. (2005)
128. Assessment of association between mitochondrial aldehyde dehydrogenase polymorphism and Alzheimer's disease in an older Korean population. (PubMed id 15123334)^{1, 9} Kim J.M....Yoon J.S. (2004)
129. Genetic polymorphisms of ADH2, ADH3, CYP4502E1 Dra-I and Pst-I, and ALDH2 in Spanish men: lack of association with alcoholism and alcoholic liver disease. (PubMed id 15519646)^{1, 9} Vidal F....Richart C. (2004)
130. Do the ethanol metabolizing enzymes modify the relationship between alcohol consumption and blood pressure? (PubMed id 12777946)^{1, 9} Saito K....Tanaka H. (2003)
131. Protective association of genetic variation in alcohol dehydrogenase with alcohol dependence in Native American Mission Indians. (PubMed id 12505800)^{1, 9} Wall T.L....Ehlers C.L. (2003)
132. An investigation of associations between alcohol use disorder and polymorphisms on ALDH2, BDNF, 5-HTTLPR, and MTHFR genes in older K orean men. (PubMed id 19637400)^{1, 9} Shin S....Yoon J.S. (2009)
133. Alcohol dehydrogenase 1B and Aldehyde dehydrogenase 2 Polymorphisms in Uzbekistan. (PubMed id 19469618)^{1, 9} Ahn K.S....Hamajima N. (2009)
134. SPINK1, ADH2, and ALDH2 gene variants and alcoholic chronic pancreatitis in Japan. (PubMed id 18336671)^{1, 9} Shimosegawa T....Masamune A. (2008)
135. Partially irreversible inactivation of mitochondrial aldehyde dehydrogenase by nitroglycerin. (PubMed id 18786921)^{1, 9} Beretta M....Gorren A.C. (2008)
136. Evidence for involvement of calcitonin gene-related peptide in nitroglycerin response and association with mitochondrial aldehyde dehydrogenase-2 (ALDH2) Glu504Lys polymorphism. (PubMed id 18772068)^{1, 9} Guo R....Li Y.J. (2008)
137. The effect of genetic polymorphisms in the vinyl chloride metabolic pathway on mutagenic risk. (PubMed id 17384900)^{1, 9} Schindler J....Brandt-Rauf P.W. (2007)
138. Diplotype trend regression analysis of the ADH gene cluster and the ALDH2 gene: multiple significant associations with alcohol dependence. (PubMed id 16685648)^{1, 9} Luo X....Gelernter J. (2006)
139. Increased DNA damage in ALDH2-deficient alcoholics. (PubMed id 17040107)^{1, 9} Matsuda T....Yokoyama A. (2006)
140. Meta-analyses of ALDH2 and ADH1B with alcohol dependence in Asians. (PubMed id 16822169)^{1, 9} Luczak S.E....Wall T.L. (2006)
141. Associations of ALDH2 and ADH1B genotypes with response to alcohol in Asian Americans. (PubMed id 15957670)^{1, 9} Cook T.A....Wall T.L. (2005)
142. Mitochondrial aldehyde dehydrogenase polymorphism is not associated with incidence of Alzheimer's disease. (PubMed id 16250071)^{1, 9} Shin I.S....Yoon J.S. (2005)
143. Genetic associations of alcohol and aldehyde dehydrogenase with alcohol dependence and their mechanisms of action. (PubMed id 16404797)^{1, 9} Wall T.L. (2005)
144. Association of aldehyde dehydrogenase-2 polymorphism with alcoholic polyneuropathy in humans. (PubMed id 15182962)^{1, 9} Masaki T....Higuchi S. (2004)
145. Association of polymorphisms in nicotinic acetylcholine receptor alpha 4 subunit gene (CHRNA4), mu-opioid receptor gene (OPRM1), and ethanol-metabolizing enzyme genes with alcoholism in Korean patients. (PubMed id 15902904)^{1, 9} Kim S.A....Chung J.H. (2004)
146. Role of alcohol and genetic polymorphisms of CYP2E1 and ALDH2 in breast cancer development. (PubMed id 12563175)^{1, 9} Choi J.Y....Kang D. (2003)
147. Polymorphisms for vinyl chloride metabolism in French vinyl chloride workers. (PubMed id 12705718)^{1, 9} Li Y....Brandt-Rauf P.W. (2003)
148. Duplex polymerase chain reaction with confronting two-pair primers (PCR-CTPP) for genotyping alcohol dehydrogenase beta subunit (ADH2) and aldehyde dehydrogenase 2 (ALDH2). (PubMed id 12915514)^{1, 9} Tamakoshi A....Tajima K. (2003)
149. Genotype of ethanol metabolizing enzyme genes by oligonucleotide microarray in alcoholic liver disease in Chinese people. (PubMed id 12173598)^{1, 9} Yu C....Yue M. (2002)
150. Association of restriction fragment-length polymorphisms in the alcohol dehydrogenase 2 gene with alcoholic brain atrophy. (PubMed id 8659684)^{4, 9} Maezawa Y....Sakurai S. (1996)
151. Genetic determinants of both ethanol and acetaldehyde metabolism influence alcohol hypersensitivity and drinking behaviour among Sca ndinavians. (PubMed id 20205700)^{1, 9} Linneberg A....Husemoen L.L. (2010)
152. Variability in ethanol biodisposition in whites is mo dulated by polymorphisms in the ADH1B and ADH1C genes. (PubMed id 20101753)^{1, 9} MartA-nez C....AgA_ndez J.A. (2010)
153. The polymorphism in aldehyde dehydrogenase-2 gene is associated with elevated plasma levels of high-sensitivity C-reactive protein i n the early phase of myocardial infarction. (PubMed id 20467232)^{1, 9} Bian Y....Zhang Y. (2010)
154. Alda-1 is an agonist and chemical chaperone for the c ommon human aldehyde dehydrogenase 2 variant. (PubMed id 20062057)^{1, 9} Perez-Miller S....Hurley T.D. (2010)
155. Alcohol and aldehyde dehydrogenase polymorphisms in C hinese and Indian populations. (PubMed id 20025435)^{1, 9} Tan E.C....Winslow M. (2010)
156. Characterization of the East Asian variant of aldehyd e dehydrogenase-2: bioactivation of nitroglycerin and effects of Alda-1. (PubMed id 19906643)^{1, 9} Beretta M....Mayer B. (2010)
157. Association of ALDH2 genotypes with periodontitis pro gression. (PubMed id 20042735)^{1, 9} Nishida N....Shizukuishi S. (2010)
158. Origin and dispersal of atypical aldehyde dehydrogenase ALDH2487Lys. (PubMed id 19393179)^{1, 9} Luo H.R....Zhang Y.P. (2009)
159. Association of ADH1B and ALDH2 gene polymorphisms with alcohol dependence: a pilot study from India. (PubMed id 19403456)^{1, 9} Vaswani M....Kapur S. (2009)
160. 5HTT polymorphisms are associated with job stress in Japanese workers. (PubMed id 19251454)^{1, 9} Katsuyama H....Saijoh K. (2009)
161. Comparison of genetic polymorphisms of CYP2E1, ADH2, and ALDH2 genes involved in alcohol metabolism in Koreans and four other ethnic groups. (PubMed id 19250143)^{1, 9} Kang T.S....Roh J. (2009)
162. Impact of multiple alcohol dehydrogenase gene polymor phisms on risk of upper aerodigestive tract cancers in a Japanese population. (PubMed id 19861527)^{1, 9} Oze I....Tanaka H. (2009)
163. Interaction of the effects of alcohol drinking and po lymorphisms in alcohol-metabolizing enzymes on the risk of female breast cancer in Japan. (PubMed id 19667493)^{1, 9} Kawase T....Tajima K. (2009)
164. Lipid hydroperoxides in human plasma after ethanol co nsumption. (PubMed id 19261511)^{1, 9} Asano M....Ueno Y. (2009)
165. Aldehyde dehydrogenase 2 and head and neck cancer: a meta-analysis implementing a Mendelian randomization approach. (PubMed id 19124505)^{1, 9} Boccia S....Boffetta P. (2009)
166. Alcohol and genetic polymorphisms: effect on risk of alcohol-related cancer. (PubMed id 19185835)^{1, 9} Druesne-Pecollo N....Latino-Martel P. (2009)
167. Pharmacokinetic and pharmacodynamic basis for overcom ing acetaldehyde-induced adverse reaction in Asian alcoholics, heterozygous for the variant ALDH2*2 gene allele. (PubMed id 19584771)^{1, 9} Chen Y.C....Yin S.J. (2009)
168. Gender differences in the genetic risk for alcohol de pendence--the results of a pharmacogenetic study in Korean alcoholics. (PubMed id 20077761)^{1, 9} Kim S.G. (2009)
169. Genetic polymorphisms of alcohol metabolising enzymes: their role in susceptibility to oesophageal cancer. (PubMed id 18254707)^{1, 9} Li D.P....Parker M.I. (2008)
170. Microsatellite scan identifies new candidate genes for susceptibility to alcoholic chronic pancreatitis in Japanese patients. (PubMed id 19096130)^{1, 9} Kitahara K....Ota M. (2008)
171. [Correlation analyses of ALDH2 and CYP2E1 genetic polymorphism with personality] (PubMed id 19230487)^{1, 9} Ohtsuka Y....Iwahashi K. (2008)
172. Alcohol-metabolizing enzyme gene polymorphisms and alcohol chronic pancreatitis among Polish individuals. (PubMed id 18773092)^{1, 9} Cichoz-Lach H....Sl/omka M. (2008)
173. Association of ADH and ALDH genes with alcohol dependence in the Irish Affected Sib Pair Study of alcohol dependence (IASPSAD) sample. (PubMed id 18331377)^{1, 9} Kuo P.H....Riley B.P. (2008)
174. Risk of metachronous squamous cell carcinoma in the upper aerodigestive tract of Japanese alcoholic men with esophageal squamous cell carcinoma: a long-term endoscopic follow-up study. (PubMed id 18429959)^{1, 9} Yokoyama A....Maruyama K. (2008)
175. The association of mitochondrial aldehyde dehydrogenase gene (ALDH2) polymorphism with susceptibility to late-onset Alzheimer's disease in Chinese. (PubMed id 18201725)^{1, 9} Wang B....Ma X. (2008)
176. Detoxification of promutagenic aldehydes derived from methylpyrenes by human aldehyde dehydrogenases ALDH2 and ALDH3A1. (PubMed id 18621017)^{1, 9} Glatt H....Kollock R. (2008)
177. Common single nucleotide polymorphisms in Japanese patients with essential hypertension: aldehyde dehydrogenase 2 gene as a risk factor independent of alcohol consumption. (PubMed id 17785925)^{1, 9} Hui P....Cheng Z. (2007)
178. Genetic polymorphisms in alcohol metabolism, alcohol intake and the risk of stomach cancer in Warsaw, Poland. (PubMed id 17631643)^{1, 9} Zhang F.F....Chow W.H. (2007)
179. Genetic polymorphisms of alcohol and aldehyde dehydrogenases, and drinking, smoking and diet in Japanese men with oral and pharyngeal squamous cell carcinoma. (PubMed id 17071628)^{1, 9} Asakage T....Watanabe H. (2007)
180. p53 Protein accumulation, cancer multiplicity, and aldehyde dehydrogenase-2 genotype in Japanese alcoholic men with early esophageal squamous cell carcinoma. (PubMed id 16759795)^{1, 9} Yokoyama A....Hibi T. (2007)
181. Alcohol dehydrogenase and aldehyde dehydrogenase polymorphisms and colorectal cancer: the Fukuoka Colorectal Cancer Study. (PubMed id 17517051)^{1, 9} Yin G....Imaizumi N. (2007)
182. Association of the aldehyde dehydrogenase 2 promoter polymorphism with alcohol consumption and reactions in an American Jewish population. (PubMed id 17850643)^{1, 9} Fischer M....Crabb D.W. (2007)
183. Alcohol dehydrogenase and aldehyde dehydrogenase gene polymorphism in alcohol liver cirrhosis and alcohol chronic pancreatitis among Polish individuals. (PubMed id 17454860)^{1, 9} Cichoz-Lach H....Wojcierowski J. (2007)
184. Impact of the alcohol-dehydrogenase (ADH) 1C and ADH1B polymorphisms on drinking behavior in nonalcoholic Japanese. (PubMed id 17285601)^{1, 9} Matsuo K....Tajima K. (2007)
185. Effect of the CYP2E1 genotype on vinyl chloride monomer-induced liver fibrosis among polyvinyl chloride workers. (PubMed id 17659824)^{1, 9} Hsieh H.I....Cheng T.J. (2007)
186. The polymorphism in acetaldehyde dehydrogenase 2 gene, causing a substitution of Glu > Lys(504), is not associated with coronary atherosclerosis severity in Han Chinese. (PubMed id 17984618)^{1, 9} Xu F....Zhang Y. (2007)
187. Contribution of the alcohol dehydrogenase-1B genotype and oral microorganisms to high salivary acetaldehyde concentrations in Japanese alcoholic men. (PubMed id 17471563)^{1, 9} Yokoyama A....Yokoyama T. (2007)
188. Association of micro-opioid receptor gene polymorphism A118G with alcohol dependence in a Japanese population. (PubMed id 16679777)^{1, 9} Nishizawa D....Ikeda K. (2006)
189. ALDH2 1510 G/A (Glu487Lys) polymorphism interaction with age in head and neck squamous cell carcinoma. (PubMed id 17033202)^{1, 9} Hashimoto T....Hinoda Y. (2006)
190. Clinical and genetic characteristics of Korean male alcoholics with and without attention deficit hyperactivity disorder. (PubMed id 16679343)^{1, 9} Kim J.W....Kim B.N. (2006)
191. Effect of -361 G/A polymorphism of aldehyde dehydrogenase-2 gene on alcohol metabolism and its expression in human peripheral blood leukocytes. (PubMed id 16734278)^{1, 9} Nishimura F.T....Saijoh K. (2006)
192. Alcohol dehydrogenase 2 His47Arg polymorphism influences drinking habit independently of aldehyde dehydrogenase 2 Glu487Lys polymorphism: analysis of 2,299 Japanese subjects. (PubMed id 16702384)^{1, 9} Matsuo K....Tajima K. (2006)
193. SPINK1 gene mutations and pancreatitis in Japan. (PubMed id 16958672)^{1, 9} Shimosegawa T....Masamune A. (2006)
194. Genetic polymorphisms of methylenetetrahydrofolate reductase and aldehyde dehydrogenase 2, alcohol use and risk of colorectal adenomas: Self-Defense Forces Health Study. (PubMed id 16108833)^{1, 9} Hirose M....Ikeda N. (2005)
195. Change of components of the metabolic syndrome in a workers' health checkup after five years--relation with elevated liver enzymes, gene polymorphisms for ALDH 2, beta3-AR and lifestyle. (PubMed id 16408483)^{1, 9} Ishikawa N....Watanabe T. (2005)
196. Disruption of the coenzyme binding site and dimer interface revealed in the crystal structure of mitochondrial aldehyde dehydrogenase 'Asian' variant. (PubMed id 15983043)^{1, 9} Larson H.N....Hurley T.D. (2005)
197. Esophageal melanosis, an endoscopic finding associated with squamous cell neoplasms of the upper aerodigestive tract, and inactive aldehyde dehydrogenase-2 in alcoholic Japanese men. (PubMed id 16082583)^{1, 9} Yokoyama A....Hibi T. (2005)
198. Influence of genetic variations of ethanol-metabolizing enzymes on phenotypes of alcohol-related disorders. (PubMed id 15542751)^{1, 9} Higuchi S....Mochizuki H. (2004)
199. Genetic polymorphisms of tobacco- and alcohol-related metabolizing enzymes and the risk of hepatocellular carcinoma. (PubMed id 12759747)^{1, 9} Munaka M....Katoh T. (2003)
200. Influence of genetic admixture on polymorphisms of alcohol-metabolizing enzymes: analyses of mutations on the CYP2E1, ADH2, ADH3 and ALDH2 genes in a Mexican-American population living in the Los Angeles area. (PubMed id 12554615)^{1, 9} Konishi T....Wan Y.J. (2003)
201. Relation among alcohol dehydrogenase 2 polymorphism, alcohol consumption, and levels of gamma-glutamyltransferase. (PubMed id 12798968)^{1, 9} Loew M....Brenner H. (2003)
202. Investigation of alcohol metabolizing enzyme genes in Chinese alcoholics with avascular necrosis of hip joint, pancreatitis and cirrhosis of the liver. (PubMed id 12915519)^{1, 9} Chao Y.C....Hsieh T.Y. (2003)
203. Allele frequencies of single nucleotide polymorphisms (SNPs) in 40 candidate genes for gene-environment studies on cancer: data from population-based Japanese random samples. (PubMed id 14634838)^{1, 9} Yoshimura K....Tsugane S. (2003)
204. Identification of a retinoid receptor response element in the human aldehyde dehydrogenase-2 promoter. (PubMed id 14691372)^{1, 9} Pinaire J....Crabb D. (2003)
205. Effects of aldehyde dehydrogenase genotypes on carotid atherosclerosis. (PubMed id 14597338)^{1, 9} Narita M....Hori M. (2003)
206. Polymorphism in alcohol-metabolizing enzymes, glutathione S-transferases and apolipoprotein E and susceptibility to alcohol-induced cirrhosis and chronic pancreatitis. (PubMed id 11966948)^{1, 9} Frenzer A....Roberts-Thomson I.C. (2002)
207. Tandem repeat polymorphism of the CYP2E1 gene: an association study with esophageal cancer and lung cancer. (PubMed id 12198369)^{1, 9} Itoga S....Harada S. (2002)
208. The genetics of alcoholism in Polynesians: alcohol and aldehyde dehydrogenase genotypes in young men. (PubMed id 12170102)^{1, 9} Chambers G.K....Chong N.L. (2002)
209. Aldehyde dehydrogenase 2 gene is a risk factor for myocardial infarction in Japanese men. (PubMed id 12452318)^{1, 9} Takagi S....Goto Y. (2002)
210. XRCC1 and CYP2E1 polymorphisms as susceptibility factors of plasma mutant p53 protein and anti-p53 antibody expression in vinyl chloride monomer-exposed polyvinyl chloride workers. (PubMed id 12010862)^{1, 9} Wong R.H....Cheng T.J. (2002)
211. Epidemiologic study of the association of low-Km mitochondrial acetaldehyde dehydrogenase genotypes with blood pressure level and the prevalence of hypertension in a general population. (PubMed id 12484509)^{1, 9} Amamoto K....Ueshima H. (2002)
212. Genotype frequencies of 50 polymorphisms for 241 Japanese non-cancer patients. (PubMed id 12164325)^{1, 9} Hamajima N....Tajima K. (2002)
213. Screening for acetaldehyde dehydrogenase 2 genotype in alcohol-induced asthma by using the ethanol patch test. (PubMed id 11692094)^{1, 9} Matsuse H....Kohno S. (2001)
214. Association of the ADH2 genotypes with skin responses after ethanol exposure in Japanese male university students. (PubMed id 11584144)^{1, 9} Takeshita T....Morimoto K. (2001)
215. Binge drinking in Chinese, Korean, and White college students: genetic and ethnic group differences. (PubMed id 11767261)^{1, 9} Luczak S.E....Carr L.G. (2001)
216. Detection of usual and atypical aldehyde dehydrogenase alleles by mismatch amplification mutation assay. (PubMed id 11798074)^{1, 9} Luo H.R....Zhang Y.P. (2001)
217. Association of aldehyde dehydrogenase 2 gene polymorphism with multiple oesophageal dysplasia in head and neck cancer patients. (PubMed id 10896918)^{4, 9} Muto M....Esumi H. (2000)
218. A novel polymorphism (-357 G/A) of the ALDH2 gene: linkage disequilibrium and an association with alcoholism. (PubMed id 10397278)^{4, 9} Harada S....Tsutsumi M. (1999)
219. Correlation between alcohol-induced asthma and acetaldehyde dehydrogenase-2 genotype. (PubMed id 9600491)^{4, 9} Takao A....Harda S. (1998)
220. Binding and activation of the human aldehyde dehydrogenase 2 promoter by hepatocyte nuclear factor 4. (PubMed id 9765594)^{1, 9} Stewart M.J....Crabb D.W. (1998)
221. Genetic polymorphism of cytochrome P-4502E1 and mitochondrial aldehyde dehydrogenase in a Korean population. (PubMed id 9309300)^{1, 9} Lee K.H.... Jeong H.S. (1997)
222. Molecular genetics of human aldehyde dehydrogenase. (PubMed id 1306115)^{1, 9} Yoshida A. (1992)
223. ALDH, CA I, and CD2AP: novel, diagnostically useful i mmunohistochemical markers to identify erythroid precursors in bone marrow biop sy specimens. (PubMed id 22180476)¹ Rollins-Raval M.A....Roth C.G. (2012)
224. Strong protective effect of the aldehyde dehydrogenase gene (ALDH2) 504lys (*2) allele against alcoholism and alcohol-induced medical diseases in Asians. (PubMed id 22102315)¹ Li D....Gelernter J. (2012)
225. Genetic risk of hepatocellular carcinoma in patients w ith hepatitis C virus: a case control study. (PubMed id 22004425)¹ Tomoda T....Shimizu K. (2012)
226. SET overexpression decreases cell detoxification effic iency: ALDH2 and GSTP1 are downregulated, DDR is impaired and DNA damage accumul ates. (PubMed id 23106910)¹ Almeida L.O....Leopoldino A.M. (2012)
227. COMT and ALDH2 polymorphisms moderate associations of implicit drinking motives with alcohol use. (PubMed id 21309949)¹ Hendershot C.S....Hutchison K.E. (2012)
228. Combination of ADH1B*2/ALDH2*2 polymorphisms alters ac etaldehyde-derived DNA damage in the blood of Japanese alcoholics. (PubMed id 22703580)¹ Yukawa Y....Matsuda T. (2012)
229. Folate, alcohol, and aldehyde dehydrogenase 2 polymorp hism and the risk of oral and pharyngeal cancer in Japanese. (PubMed id 21946912)¹ Matsuo K....La Vecchia C. (2012)
230. Acetylation-dependent regulation of mitochondrial ALDH 2 activation by SIRT3 mediates acute ethanol-induced eNOS activation. (PubMed id 22155639)¹ Xue L....Chen Y. (2012)
231. Breath alcohol elimination rate and Widmark factor der ived from breath alcohol concentration in Chinese and Indians in Singapore. (PubMed id 22287615)¹ Limenta L.M....Lee E.J. (2012)
232. The acute effects of ethanol and acetaldehyde on physi ological responses after ethanol ingestion in young healthy men with different A LDH2 genotypes. (PubMed id 22455355)¹ Bae K.Y....Yoon J.S. (2012)
233. Genome-wide association study for intracranial aneurys m in the Japanese population identifies three candidate susceptible loci and a f unctional genetic variant at EDNRA. (PubMed id 22286173)¹ Low S.K....Nakamura Y. (2012)
234. Association of an aldehyde dehydrogenase 2 (ALDH2) gen e polymorphism with hyper-low-density lipoprotein cholesterolemia in a Japanese population. (PubMed id 22870576)¹ Kotani K....Yamada T. (2012)
235. Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations. (PubMed id 22797727)¹ Okada Y....Tanaka T. (2012)
236. Vascular bioactivation of nitroglycerin by aldehyde de hydrogenase-2: reaction intermediates revealed by crystallography and mass spect rometry. (PubMed id 22988236)¹ Lang B.S....Gruber K. (2012)
237. Genetic variation in alcohol dehydrogenase (ADH1A, ADH 1B, ADH1C, ADH7) and aldehyde dehydrogenase (ALDH2), alcohol consumption and gas tric cancer risk in the European Prospective Investigation into Cancer and Nutri tion (EPIC) cohort. (PubMed id 22144473)¹ Duell E.J....Gonzalez C.A. (2012)
238. Genetic polymorphisms of ALDH2 and ADH2 are not associ ated with risk of hepatocellular carcinoma among East Asians. (PubMed id 22231434)¹ Zhou D....Yang Y. (2012)
239. The aldehyde dehydrogenase 2 gene is associated with h eroin dependence. (PubMed id 21723677)¹ Wang T.Y....Lu R.B. (2012)
240. A genome-wide association and gene-environment interac tion study for serum triglycerides levels in a healthy Chinese male population. (PubMed id 22171074)¹ Tan A....Xu J. (2012)
241. Evaluation of moderate alcohol use and cognitive funct ion among men using a Mendelian randomization design in the Guangzhou biobank co hort study. (PubMed id 22302076)¹ Au Yeung S.L....Schooling C.M. (2012)
242. [ALDH2 polymorphisms and clinical medicine]. (PubMed id 22708399)¹ Yoshihara T. and Sasaguri T. (2012)
243. Genome-wide association study of coronary artery disea se in the Japanese. (PubMed id 21971053)¹ Takeuchi F....Kato N. (2012)
244. Genome-wide association analyses of esophageal squamou s cell carcinoma in Chinese identify multiple susceptibility loci and gene-envir onment interactions. (PubMed id 22960999)¹ Wu C....Lin D. (2012)
245. Influence of ALDH2 Glu504Lys polymorphism on nitroglyc erin response in chronic heart failure and involvement of Calcitonin Gene Relate d Peptide (CGRP). (PubMed id 22909898)¹ Peng L.M....Li C.C. (2012)
246. ADH and ALDH polymorphisms and alcohol dependence in M exican and Native Americans. (PubMed id 22931071)¹ Ehlers C.L....Gizer I.R. (2012)
247. Dysplastic lesions in inflammatory bowel disease show increased positivity for the stem cell marker aldehyde dehydrogenase. (PubMed id 21820149)¹ Toll A.D....Palazzo J.P. (2012)
248. Aldehyde-stress resulting from Aldh2 mutation promotes osteoporosis due to impaired osteoblastogenesis. (PubMed id 22508505)¹ Hoshi H....Miyamoto T. (2012)
249. Effect of mitochondrial aldehyde dehydrogenase-2 genot ype on cardioprotection in patients with congenital heart disease. (PubMed id 22507973)¹ Zhang H....Hu S. (2012)
250. Alcohol drinking, mean corpuscular volume of erythrocy tes, and alcohol metabolic genotypes in drunk drivers. (PubMed id 21917409)¹ Pavanello S....Montisci M. (2012)
251. Common ALDH2 genetic variants predict development of h ypertension in the SAPPHIRe prospective cohort: gene-environmental interaction w ith alcohol consumption. (PubMed id 22839215)¹ Chang Y.C....Chuang L.M. (2012)
252. The ALDH2 and 5-HT2A genes interacted in bipolar-I but not bipolar-II disorder. (PubMed id 22564712)¹ Lee S.Y....Lu R.B. (2012)
253. [Alcohol metabolism at moderate drinking in healthy m en. Comparison between differences of alcohol beverages, with and without meal, and genetic polymorphism]. (PubMed id 21861333)¹ Oshima S....Ohno Y. (2011)
254. Esophageal squamous cell carcinoma and ALDH2 and ADH1B polymorphisms in Chinese females. (PubMed id 22292652)¹ Wang Y....Xia S. (2011)
255. Meta-analysis of aldehyde dehydrogenase 2 gene polymo rphism and Alzheimer's disease in East Asians. (PubMed id 21515512)¹ Hao P.P....Zhang Y. (2011)
256. ALDH2 and ADH1B interactions in retrospective reports of low-dose reactions and initial sensitivity to alcohol in Asian American colle ge students. (PubMed id 21355870)¹ Luczak S.E....Wall T.L. (2011)
257. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)
258. Genetic testing for aldehyde dehydrogenase 2 deficien cy in young adults. (PubMed id 21321583)¹ Hendershot C.S. (2011)
259. p53 protein accumulation, iodine-unstained lesions, a nd alcohol dehydrogenase-1B and aldehyde dehydrogenase-2 genotypes in Japanese alcoholic men with esophageal dysplasia. (PubMed id 21601984)¹ Yokoyama A....Omori T. (2011)
260. Association between alcohol intake and risk for gastr ic cancer with regard to ALDH2 genotype in the Korean population. (PubMed id 21507992)¹ Shin C.M....Song I.S. (2011)
261. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)¹ OlA!h J....OvA!di J. (2011)
262. Alcohol ingestion and colorectal neoplasia: a meta-an alysis based on a Mendelian randomization approach. (PubMed id 21114754)¹ Wang J....Zhang Y. (2011)
263. The role of ALDH2 and ADH1B polymorphism in alcohol co nsumption and stroke in Han Chinese. (PubMed id 22155604)¹ Yao C.T....Peng G.S. (2011)
264. Gender differences in the effects of ADH1B and ALDH2 p olymorphisms on alcoholism. (PubMed id 21848961)¹ Kimura M....Higuchi S. (2011)
265. Deficiency of insulin-like growth factor 1 reduces vu lnerability to chronic alcohol intake-induced cardiomyocyte mechanical dysfunct ion: role of AMPK. (PubMed id 20731752)¹ Ge W....Ren J. (2011)
266. Genome-wide association studies identify genetic loci related to alcohol consumption in Korean men. (PubMed id 21270382)¹ Baik I....Shin C. (2011)
267. Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
268. A genome-wide association study of upper aerodigestiv e tract cancers conducted within the INHANCE consortium. (PubMed id 21437268)¹ McKay J.D....Brennan P. (2011)
269. Meta-analysis of genome-wide association studies iden tifies common variants associated with blood pressure variation in east Asians. (PubMed id 21572416)¹ Kato N....He J. (2011)
270. Evaluating a Cognitive Model of ALDH2 and Drinking Be havior. (PubMed id 21039630)¹ Hendershot C.S....Larimer M.E. (2011)
271. Regulation of human mitochondrial aldehyde dehydrogen ase (ALDH-2) activity by electrophiles in vitro. (PubMed id 21252222)¹ Oelze M....Daiber A. (2011)
272. ADH1B and ALDH2 polymorphisms and their associations with increased risk of squamous cell carcinoma of the head and neck in the Kore an population. (PubMed id 21576033)¹ Ji Y.B....Shin H.D. (2011)
273. Confirmation of ALDH2 as a Major locus of drinking be havior and of its variants regulating multiple metabolic phenotypes in a Japane se population. (PubMed id 21372407)¹ Takeuchi F....Kato N. (2011)
274. ALDH2 in alcoholic heart diseases: molecular mechanis m and clinical implications. (PubMed id 21664374)¹ Zhang Y. and Ren J. (2011)
275. Acetaldehyde dehydrogenase 2 SNP rs671 and susceptibi lity to essential hypertension in Mongolians: a case control study. (PubMed id 21476199)¹ Hasi T....Su X.L. (2011)
276. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
277. Site-directed mutagenesis of aldehyde dehydrogenase-2 suggests three distinct pathways of nitroglycerin biotransformation. (PubMed id 21536753)¹ Wenzl M.V....Gorren A.C. (2011)
278. Multi-susceptibility genes associated with the risk o f the development stages of esophageal squamous cell cancer in Feicheng County. (PubMed id 21672255)¹ Li Q.D....Li Q.H. (2011)
279. Role of aldehyde dehydrogenase 2 Glu504lys polymorphi sm in acute coronary syndrome. (PubMed id 21958412)¹ Xu F....Zhang Y. (2011)
280. A genome-wide association study of hypertension-relat ed phenotypes in a Japanese population. (PubMed id 20877124)¹ Hiura Y....Iwai N. (2010)
281. Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)¹ Bennett E.J....Harper J.W. (2010)
282. Alcohol dehydrogenase 2 genotype and risk for migrain e. (PubMed id 19486361)¹ GarcA-a-MartA-n E....JimAcnez-JimAcnez F.J. (2010)
283. Genetic polymorphisms in folate and alcohol metabolis m and breast cancer risk: a case-control study in Thai women. (PubMed id 20180013)¹ Sangrajrang S....Yoshida T. (2010)
284. Strong interaction between the effects of alcohol con sumption and smoking on oesophageal squamous cell carcinoma among individuals w ith ADH1B and/or ALDH2 risk alleles. (PubMed id 20833657)¹ Tanaka F....Mori M. (2010)
285. Modification of the relationship between urinary 8-OH dG and hippuric acid concentration by GSTM1, GSTT1, and ALDH2 genotypes. (PubMed id 20488846)¹ Kim Y.D....Kim H. (2010)
286. Sex-specific proteome differences in the anterior cin gulate cortex of schizophrenia. (PubMed id 20381070)¹ Martins-de-Souza D....Turck C.W. (2010)
287. Alcohol and aldehyde dehydrogenase polymorphisms and risk for suicide: a preliminary observation in the Japanese male population. (PubMed id 20180859)¹ Hishimoto A....Shirakawa O. (2010)
288. Mitochondrial aldehyde dehydrogenase mediates vasodil ator responses of glyceryl trinitrate and sodium nitrite in the pulmonary vascu lar bed of the rat. (PubMed id 20543077)⁷ Badejo A.M....Kadowitz P.J. (2010)
289. The ALDH2 Glu504Lys polymorphism is associated with c oronary artery disease in Han Chinese: Relation with endothelial ADMA levels. (PubMed id 20417517)¹ Guo Y.J....Chen X.P. (2010)
290. Network organization of the human autophagy system. (PubMed id 20562859)¹ Behrends C....Harper J.W. (2010)
291. Impact of smoking on lung cancer risk is stronger in those with the homozygous aldehyde dehydrogenase 2 null allele in a Japanese po pulation. (PubMed id 20093384)¹ Park J.Y....Tanaka H. (2010)
292. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)¹ Hendrickson S.L....O'Brien S.J. (2010)
293. Genome-wide association study of hematological and bi ochemical traits in a Japanese population. (PubMed id 20139978)¹ Kamatani Y....Kamatani N. (2010)
294. Polymorphisms of alcohol dehydrogenase-1B and aldehyd e dehydrogenase-2 and the blood and salivary ethanol and acetaldehyde concentra tions of Japanese alcoholic men. (PubMed id 20477767)¹ Yokoyama A....Yokoyama T. (2010)
295. Prevalence and persistence of chromosomal damage and susceptible genotypes of metabolic and DNA repair genes in Chinese vinyl chlori de-exposed workers. (PubMed id 20100738)¹ Ji F....Christiani D.C. (2010)
296. Relationship between genetic polymorphisms of ALDH2 a nd ADH1B and esophageal cancer risk: a meta-analysis. (PubMed id 20806441)¹ Yang S.J....Yang C.X. (2010)
297. A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome. (PubMed id 20186120)¹ Richter R....Chrzanowska-Lightowlers Z.M. (2010)
298. Alcohol dehydrogenase-2 and aldehyde dehydrogenase-2 genotypes, alcohol drinking and the risk for stomach cancer in Chinese males. (PubMed id 21133627)¹ Cao H.X....Ding J.H. (2010)
299. Association of aldehyde dehydrogenase 2 gene polymorp hism with pancreatic cancer but not colon cancer. (PubMed id 20590827)¹ Miyasaka K....Funakoshi A. (2010)
300. High ALDH activity identifies chemotherapy-resistant Ewing's sarcoma stem cells that retain sensitivity to EWS-FLI1 inhibition. (PubMed id 21085683)¹ Awad O....Loeb D.M. (2010)
301. MAOA interacts with the ALDH2 gene in anxiety-depress ion alcohol dependence. (PubMed id 20477771)¹ Lee S.Y....Lu R.B. (2010)
302. The ALDH2 and DRD2/ANKK1 genes interacted in bipolar II but not bipolar I disorder. (PubMed id 20577142)¹ Lee S.Y....Lu R.B. (2010)
303. Genetic susceptibility to distinct bladder cancer sub phenotypes. (PubMed id 19692168)¹ Guey L.T....Malats N. (2010)
304. Deficient aldehyde dehydrogenase 2 is associated with increased risk for esophageal squamous cell carcinoma in the presence of gastr ic hypochlorhydria. (PubMed id 20521872)¹ Oikawa T....Shimosegawa T. (2010)
305. Interaction among genes influencing ethanol metabolis m and sex is association with alcohol use disorders in a Tibet population. (PubMed id 19655364)¹ Guo W....Hu X. (2010)
306. Alcohol, tobacco and genetic susceptibility in relati on to cancers of the upper aerodigestive tract in northern Italy. (PubMed id 20437850)¹ Canova C....Simonato L. (2010)
307. Effects of alcohol-drinking behaviour and ADH1B and A LDH2 polymorphisms on basal DNA damage in human mononuclear cells as determined by the comet assay. (PubMed id 20685249)¹ Weng H....Morimoto K. (2010)
308. Interaction between ALDH2*1*1 and DRD2/ANKK1 TaqI A1A 1 genes may be associated with antisocial personality disorder not co-morbid wi th alcoholism. (PubMed id 21070510)¹ Lu R.B....Ko H.C. (2010)
309. The association of alcohol and alcohol metabolizing g ene variants with diabetes and coronary heart disease risk factors in a white p opulation. (PubMed id 20700531)¹ Husemoen L.L....Linneberg A. (2010)
310. Genetic variation in 3-hydroxy-3-methylglutaryl CoA r eductase modifies the chemopreventive activity of statins for colorectal cancer . (PubMed id 20403997)¹ Lipkin S.M....Gruber S.B. (2010)
311. Polymorphisms of alcohol metabolizing enzymes in indi genous Mexican population: unusual high frequency of CYP2E1*c2 allele. (PubMed id 19860798)¹ Gordillo-Bastidas E....Bastidas-RamA-rez B.E. (2010)
312. Evaluation of a brief web-based genetic feedback inte rvention for reducing alcohol-related health risks associated with ALDH2. (PubMed id 20652463)¹ Hendershot C.S....Wall T.L. (2010)
313. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)¹ Bailey S.D....Anand S. (2010)
314. Association of genetic polymorphisms of aldehyde dehy drogenase-2 with esophageal squamous cell dysplasia. (PubMed id 20632450)¹ Zhou Y.Z....Cui J. (2010)
315. Meta-analysis of ADH1B and ALDH2 polymorphisms and es ophageal cancer risk in China. (PubMed id 21157980)¹ Zhang G.H....Huang B. (2010)
316. Distribution of ADH1B, ALDH2, CYP2E1 *6, and CYP2E1 * 7B genotypes in Turkish population. (PubMed id 20598484)¹ KayaaltA+ Z. and SAPylemezoA9lu T. (2010)
317. Association between aldehyde dehydrogenase 2 genetic polymorphism and serum lipids or lipoproteins: a meta-analysis of seven East As ian populations. (PubMed id 20541757)¹ Hao P.P....Zhang Y. (2010)
318. Comparison between self-reported facial flushing afte r alcohol consumption and ALDH2 Glu504Lys polymorphism for risk of upper aerodi gestive tract cancer in a Japanese population. (PubMed id 20518787)¹ Oze I....Tanaka H. (2010)
319. Gene-environmental interaction regarding alcohol-metabolizing enzymes in the Japanese general population. (PubMed id 19262484)¹ Tsuchihashi-Makaya M....Kato N. (2009)
320. Determination of genetic predisposition to patent ductus arteriosus in preterm infants. (PubMed id 19336370)¹ Dagle J.M....Murray J.C. (2009)
321. Integrative predictive model of coronary artery calci fication in atherosclerosis. (PubMed id 19948975)¹ McGeachie M....Ramoni M.F. (2009)
322. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PubMed id 19343046)¹ Saito A....Kamatani N. (2009)
323. ALDH2, ADH1B and alcohol expectancies: integrating ge netic and learning perspectives. (PubMed id 19769429)¹ Hendershot C.S....Larimer M.E. (2009)
324. Candidate gene polymorphisms for diabetes mellitus, c ardiovascular disease and cancer are associated with longevity in Koreans. (PubMed id 19641380)¹ Park J.W....Park J. (2009)
325. Genetic associations of 115 polymorphisms with cancers of the upper aerodigestive tract across 10 European countries: the ARCAGE project. (PubMed id 19339270)¹ Canova C....Brennan P. (2009)
326. Effects of polymorphisms in untranslated regions of t he class I alcohol dehydrogenase (ADH) genes on alcohol metabolism in Japanese subjects and transcriptional activity in HepG2 cells. (PubMed id 19618839)¹ Nishimura F.T....Saijoh K. (2009)
327. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PubMed id 19170196)¹ Shen M....Lan Q. (2009)
328. Transgenic overexpression of aldehyde dehydrogenase-2 rescues chronic alcohol intake-induced myocardial hypertrophy and contractile dysfunction. (PubMed id 19332462)¹ Doser T.A....Ren J. (2009)
329. Effect of the allelic variants of aldehyde dehydrogenase ALDH2*2 and alcohol dehydrogenase ADH1B*2 on blood acetaldehyde concentrations. (PubMed id 19164089)¹ Peng G.S. and Yin S.J. (2009)
330. Genetical genomic determinants of alcohol consumption in rats and humans. (PubMed id 19874574)¹ Tabakoff B....Hoffman P.L. (2009)
331. Refined geographic distribution of the oriental ALDH2 *504Lys (nee 487Lys) variant. (PubMed id 19456322)¹ Li H....Kidd K.K. (2009)
332. Aldehyde dehydrogenase activity among primary leukemi a cells is associated with stem cell features and correlates with adverse clini cal outcomes. (PubMed id 19819294)¹ Ran D....Ho A.D. (2009)
333. Is habitual alcohol drinking associated with reduced electrophoretic DNA migration in peripheral blood leukocytes from ALDH2-deficient male Japanese? (PubMed id 19286920)¹ Lu Y. and Morimoto K. (2009)
334. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)¹ Talmud P.J.... . (2009)
335. PTEN identified as important risk factor of chronic o bstructive pulmonary disease. (PubMed id 19625176)¹ Hosgood H.D....Lan Q. (2009)
336. Polymorphisms in the promoter region of the human class II alcohol dehydrogenase (ADH4) gene affect both transcriptional activity and ethanol metabolism in Japanese subjects. (PubMed id 19182438)¹ Kimura Y....Saijoh K. (2009)
337. Candidate gene association study of esophageal squamo us cell carcinoma in a high-risk region in Iran. (PubMed id 19826048)¹ Akbari M.R....Narod S.A. (2009)
338. Functional variants in ADH1B and ALDH2 coupled with a lcohol and smoking synergistically enhance esophageal cancer risk. (PubMed id 19698717)¹ Cui R....Matsuda K. (2009)
339. Risk of malignant pleural mesothelioma and polymorphi sms in genes involved in the genome stability and xenobiotics metabolism. (PubMed id 19751749)¹ Gemignani F....Landi S. (2009)
340. [Molecular genetics of alcohol dependence] (PubMed id 18516948)¹ Ujike H. (2008)
341. Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. (PubMed id 18676680)¹ Hosgood H.D....Lan Q. (2008)
342. Effects of functional polymorphisms related to catecholaminergic systems on changes in blood catecholamine and cardiovascular measures after alcohol ingestion in the Japanese population. (PubMed id 18715275)¹ Nishimura F.T....Saijoh K. (2008)
343. The association between DRD2/ANKK1, 5-HTTLPR gene, and specific personality trait on antisocial alcoholism among Han Chinese in Taiwan. (PubMed id 17948892)¹ Wu C.Y....Lu R.B. (2008)
344. Statistical analysis of the associations between polymorphisms within aldehyde dehydrogenase 2 (ALDH2), and quantitative and qualitative traits extracted from a large-scale database of Japanese single-nucleotide polymorphisms (SNPs). (PubMed id 18317873)¹ Nose J....Kamatani N. (2008)
345. Polymorphisms in mitochondrial genes and prostate can cer risk. (PubMed id 19064571)¹ Wang L....Thibodeau S.N. (2008)
346. Screening of 214 single nucleotide polymorphisms in 44 candidate cancer susceptibility genes: a case-control study on gastric and colorectal cancers in the Japanese population. (PubMed id 18510611)¹ Ikeda S....Tsugane S. (2008)
347. Prevalence and risk factors of atrophic gastritis and intestinal metaplasia in a Korean population without significant gastroduodenal disease. (PubMed id 18665932)¹ Kim N....Song I.S. (2008)
348. Bioactivation of nitroglycerin by purified mitochondrial and cytosolic aldehyde dehydrogenases. (PubMed id 18450747)¹ Beretta M....Mayer B. (2008)
349. Major genetic components underlying alcoholism in Korean population. (PubMed id 18056758)¹ Kim D.J....Shin H.D. (2008)
350. Estimation of single-nucleotide polymorphism allele frequency by alternately binding probe competitive polymerase chain reaction. (PubMed id 18215653)¹ Noda N....Sekiguchi Y. (2008)
351. Sex differences in environmental and genetic factors for hypertension. (PubMed id 18724972)¹ Ruixing Y....Yuming C. (2008)
352. A comprehensive analysis of phase I and phase II metabolism gene polymorphisms and risk of non-small cell lung cancer in smokers. (PubMed id 18258609)¹ Zienolddiny S....Haugen A. (2008)
353. Impact of alcohol consumption with polymorphisms in alcohol-metabolizing enzymes on pancreatic cancer risk in Japanese. (PubMed id 19068087)¹ Kanda J....Tanaka H. (2008)
354. Alcohol intake and blood pressure: a systematic review implementing a Mendelian randomization approach. (PubMed id 18318597)¹ Chen L....Lewis S.J. (2008)
355. The association of ADH and ALDH gene variants with alcohol drinking habits and cardiovascular disease risk factors. (PubMed id 18782342)¹ Husemoen L.L....Linneberg A. (2008)
356. Genetic Contributions to the Development of Retinopathy of Prematurity. (PubMed id 18787502)¹ Mohamed S....Dagle J.M. (2008)
357. Associations of ADH and ALDH2 gene variation with self report alcohol reactions, consumption and dependence: an integrated analysis. (PubMed id 18996923)¹ Macgregor S....Whitfield J.B. (2008)
358. Pharmacokinetic and pharmacodynamic basis for partial protection against alcoholism in Asians, heterozygous for the variant ALDH2*2 gene allele. (PubMed id 17885622)¹ Peng G.S....Yin S.J. (2007)
359. Real-time PCR genotyping of aldehyde dehydrogenase-2 using displacing probes. (PubMed id 17854793)¹ Gu Y. and Li Q. (2007)
360. The activity of class I, II, III, and IV of alcohol dehydrogenase isoenzymes and aldehyde dehydrogenase in pancreatic cancer. (PubMed id 17632320)¹ Jelski W....Szmitkowski M. (2007)
361. A polymorphism of the aldehyde dehydrogenase 2 gene is a risk factor for multiple lacunar infarcts in Japanese men: the Takahata Study. (PubMed id 17388993)¹ Nagasawa H....Kato T. (2007)
362. The role of acetaldehyde in upper digestive tract cancer in alcoholics. (PubMed id 17543846)¹ Seitz H.K. and Meier P. (2007)
363. Sex differences, alcohol dehydrogenase, acetaldehyde burst, and aversion to ethanol in the rat: a systems perspective. (PubMed id 17488809)⁷ Quintanilla M.E....Israel Y. (2007)
364. Refractive hypotension in a patient with disulfiram-e thanol reaction. (PubMed id 17220694)⁷ Ho M.P....Lee C.C. (2007)
365. Gene-gene and gene-environment interactions between alcohol drinking habit and polymorphisms in alcohol-metabolizing enzyme genes and the risk of head and neck cancer in Japan. (PubMed id 17489985)¹ Hiraki A....Tajima K. (2007)
366. Association analysis of the dopamine receptor D2 (DRD2) SNP rs1076560 in alcoholic patients. (PubMed id 17196743)¹ Sasabe T....Ishiura S. (2007)
367. ALDH2 polymorphisms and bone mineral density in an elderly Japanese population. (PubMed id 16520888)¹ Yamaguchi J....Hamajima N. (2006)
368. Do alcohol-metabolizing enzyme gene polymorphisms increase the risk of alcoholism and alcoholic liver disease? (PubMed id 16440362)¹ Zintzaras E....Vidal F. (2006)
369. How many drug targets are there? (PubMed id 17139284)⁷ Overington J.P....Hopkins A.L. (2006)
370. Drugs, their targets and the nature and number of dru g targets. (PubMed id 17016423)⁷ Imming P....Meyer A. (2006)
371. Mitochondrial aldehyde dehydrogenase attenuates hyperoxia-induced cell death through activation of ERK/MAPK and PI3K-Akt pathways in lung epithelial cells. (PubMed id 16782756)¹ Xu D....Truog W.E. (2006)
372. Association of alcohol-metabolizing genes with alcoholism in a Mexican Indian (Otomi) population. (PubMed id 17134659)¹ Montano Loza A.J....Gutierrez Reyes G. (2006)
373. Association of V227A PPARalpha polymorphism with altered serum biochemistry and alcohol drinking in Japanese men. (PubMed id 16847426)¹ Naito H....Nakajima T. (2006)
374. ALDH2 genotype-associated differences in the acute effects of alcohol on P300, psychomotor performance, and subjective response in healthy young Korean men: a double-blind placebo-controlled crossover study. (PubMed id 16565959)¹ Shin H.Y....Yoon J.S. (2006)
375. Polymorphisms of alcohol-metabolizing enzymes and the risk for alcoholism and alcoholic liver disease in Caucasian Spanish women. (PubMed id 16600530)¹ Lorenzo A....Richart C. (2006)
376. [Polymorphisms of aldehyde and alcohol dehydrogenase genes associated with susceptibility to trichloroethylene-induced medicamentosa-like dermatitis] (PubMed id 16758956)¹ Li H.S....Sun Y.F. (2006)
377. ALDH2*2 is associated with a decreased likelihood of alcohol-induced blackouts in Asian American college students. (PubMed id 16608143)¹ Luczak S.E....Wall T.L. (2006)
378. The UChA and UChB rat lines: metabolic and genetic di fferences influencing ethanol intake. (PubMed id 16961761)⁷ Quintanilla M.E....Tampier L. (2006)
379. Certain background factors exhibit an association with an increased risk for pancreatic calcification among Japanese male alcoholics. (PubMed id 16163053)¹ Nakamura Y....Maruyama K. (2005)
380. Psychosocial, cultural and genetic influences on alcohol use in Asian American youth. (PubMed id 15957669)¹ Hendershot C.S....Wall T.L. (2005)
381. Inhibition of mitochondrial aldehyde dehydrogenase by nitric oxide-mediated S-nitrosylation. (PubMed id 16242127)⁷ Moon K.H....Song B.J. (2005)
382. Hangover susceptibility in relation to aldehyde dehydrogenase-2 genotype, alcohol flushing, and mean corpuscular volume in Japanese workers. (PubMed id 16046871)¹ Yokoyama M....Nakamura H. (2005)
383. ALDH2 genotype is associated in the relation between alcohol intake and periodontitis. (PubMed id 17138329)¹ Merchant A.T. (2005)
384. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)¹ Stelzl U.... Wanker E.E. (2005)
385. No alcoholism-protection effects of ADH1B*2 allele in antisocial alcoholics among Han Chinese in Taiwan. (PubMed id 16385179)¹ Lu R.B....Chou Y.H. (2005)
386. Comparative analyses of four different methods of genotyping ALDH2. (PubMed id 15318097)¹ Itoga S....Nomura F. (2004)
387. Association of ALDH(2) genotypes and alcohol consumption with periodontitis. (PubMed id 14742656)¹ Nishida N....Shizukuishi S. (2004)
388. Pooled analysis of alcohol dehydrogenase genotypes and head and neck cancer: a HuGE review. (PubMed id 14693654)¹ Brennan P....Benhamou S. (2004)
389. The evolution and population genetics of the ALDH2 locus: random genetic drift, selection, and low levels of recombination. (PubMed id 15008789)¹ Oota H....Kidd K.K. (2004)
390. ALDH2 status and conduct disorder mediate the relationship between ethnicity and alcohol dependence in Chinese, Korean, and White American college students. (PubMed id 15122947)¹ Luczak S.E....Carr L.G. (2004)
391. Relation of genotypes of alcohol metabolizing enzymes and mortality of liver diseases in patients with alcohol dependence. (PubMed id 15511718)¹ Chen C.C....Yin S.J. (2004)
392. Aldehyde dehydrogenase 2 genotype in type 1 diabetes mellitus. (PubMed id 12706323)¹ Suzuki Y....Matsuoka K. (2003)
393. Aldehyde dehydrogenase 2 genotypes, alcohol flushing symptoms and drinking patterns in Thai men. (PubMed id 12759156)¹ Assanangkornchai S....Ratanachaiyavong S. (2003)
394. Candidate genes for alcohol dependence: a review of genetic evidence from human studies. (PubMed id 12766633)⁴ Dick D.M. and Foroud T. (2003)
395. Maternal inheritance of diabetes is associated with inactive ALDH2 genotype in diabetics with renal failure in Japanese. (PubMed id 12706324)¹ Suzuki Y....Ohta S. (2003)
396. Coenzyme isomerization is integral to catalysis in al dehyde dehydrogenase. (PubMed id 12795606)¹ Perez-Miller S.J. and Hurley T.D. (2003)
397. Low-penetrance genes and their involvement in colorectal cancer susceptibility. (PubMed id 12433710)⁴ de Jong M.M....Kleibeuker J.H. (2002)
398. Allele Frequencies of 25 Polymorphisms Pertaining to Cancer Risk for Japanese, Koreans and Chinese. (PubMed id 12718576)¹ Hamajima N....Tajima K. (2002)
399. Lifestyle habits and genetic susceptibility and the risk of esophageal cancer in the Thai population. (PubMed id 12213289)¹ Boonyaphiphat P....Puttawibul P. (2002)
400. Effects of aldehyde dehydrogenase-2 genetic polymorphisms on metabolism of structurally different aldehydes in human liver. (PubMed id 11744614)¹ Wang R.S....Honma T. (2002)
401. Interaction between alcohol dehydrogenase II gene, alcohol consumption, and risk for breast cancer. (PubMed id 12189549)¹ Sturmer T....Brenner H. (2002)
402. Effects of alcohol intake on ambulatory blood pressure, heart rate, and heart rate variability in Japanese men with different ALDH2 genotypes. (PubMed id 12082496)¹ Minami J....Matsuoka H. (2002)
403. Assessment of a difference in ALDH2 heterozygotes and alcoholic liver injury. (PubMed id 12198368)¹ Nagata N....Matsuzaki S. (2002)
404. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
405. Genetic variation in aldehyde dehydrogenase 2 and the effect of alcohol consumption on cholesterol levels. (PubMed id 12119207)¹ Nakamura Y....Ueshima H. (2002)
406. Aldehyde dehydrogenase 2 (ALDH2) genotype affects rectal cancer susceptibility due to alcohol consumption. (PubMed id 12033531)¹ Matsuo K....Tajima K. (2002)
407. Effects of aldehyde dehydrogenase-2 genotype on cardiovascular and endocrine responses to alcohol in young Japanese subjects. (PubMed id 12492137)¹ Nishimura F.T....Nishijo H. (2002)
408. Genetic risk for alcoholism relates to level of response to alcohol in Asian-American men and women. (PubMed id 11925062)¹ Luczak S.E....Wall T.L. (2002)
409. Genetic differences in ethanol metabolizing enzymes and blood pressure in Japanese alcohol consumers. (PubMed id 12080432)¹ Yamada Y....Honda R. (2002)
410. Contribution of genetic polymorphisms in ethanol-metabolizing enzymes to problem drinking behavior in middle-aged Japanese men. (PubMed id 12211622)¹ Sun F....Yamada Y. (2002)
411. Relationship between genetic polymorphisms of alcohol-metabolizing enzymes and changes in risk factors for coronary heart disease associated with alcohol consumption. (PubMed id 12089173)¹ Hashimoto Y....Nakahara K. (2002)
412. The aldehyde dehydrogenase 2 gene is a risk factor for hypertension in Japanese but does not alter the sensitivity to pressor effects of alcohol: the Suita study. (PubMed id 11510748)¹ Takagi S....Ogihara T. (2001)
413. Alcohol dehydrogenase-2*2 allele is associated with decreased prevalence of fetal alcohol syndrome in the mixed-ancestry population of the Western Cape Province, South Africa. (PubMed id 11781503)⁴ Viljoen D.L....Li T.K. (2001)
414. The N-terminal portion of mature aldehyde dehydrogenase affects protein folding and assembly. (PubMed id 11468345)¹ Zhou J. and Weiner H. (2001)
415. The Protein Data Bank. (PubMed id 10592235)⁷ Berman H.M....Bourne P.E. (2000)
416. Allele association studies with SSR and SNP markers at known physical distances within a 1 Mb region embracing the ALDH2 locus in the Japanese, demonstrates linkage disequilibrium extending up to 400 kb. (PubMed id 11115843)¹ Koch H.G....Craig I.W. (2000)
417. HBV/HCV Infection, Alcohol, Tobacco and Genetic Polymorphisms for Hepatocellular Carcinoma in Nagoya, Japan. (PubMed id 12718671)¹ Koide T....Tokudome S. (2000)
418. Structure of mitochondrial aldehyde dehydrogenase: th e genetic component of ethanol aversion. (PubMed id 9195888)¹ Steinmetz C.G....Hurley T.D. (1997)
419. The mutation in the mitochondrial aldehyde dehydrogenase (ALDH2) gene responsible for alcohol-induced flushing increases turnover of the enzyme tetramers in a dominant fashion. (PubMed id 8903321)¹ Xiao Q....Crabb D.W. (1996)
420. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)¹ Bonaldo M.F.... Soares M.B. (1996)
421. The aldehyde dehydrogenase ALDH2*2 allele exhibits dominance over ALDH2*1 in transduced HeLa cells. (PubMed id 7593603)¹ Xiao Q....Crabb D.W. (1995)
422. Association of a restriction fragment length polymorphism in the alcohol dehydrogenase 2 gene with Japanese alcoholic liver cirrhosis. (PubMed id 8583138)⁴ Yamauchi M....Sakurai S. (1995)
423. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)¹ Maruyama K. and Sugano S. (1994)
424. Genotypes for aldehyde dehydrogenase deficiency and alcohol sensitivity. The inactive ALDH2(2) allele is dominant. (PubMed id 2562960)¹ Crabb D.W....Li T.K. (1989)
425. Genotypes of alcohol-metabolizing enzymes in Japanese with alcohol liver diseases: a strong association of the usual Caucasian-type aldehyde dehydrogenase gene (ALDH1(2)) with the disease. (PubMed id 3189338)⁴ Shibuya A. and Yoshida A. (1988)
426. The structural gene for the mitochondrial aldehyde dehydrogenase maps to human chromosome 12. (PubMed id 3017845)¹ Braun T....Goedde H.W. (1986)
427. Expression of aldehyde dehydrogenase 2 in the normal esophageal epithelium and alcohol consumption in patients with esophageal cancer. (PubMed id 15970497)⁹ Morita M....Yasumoto K. (2005)
428. Inactive aldehyde dehydrogenase 2 worsens glycemic control in patients with type 2 diabetes mellitus who drink low to moderate amounts of alcohol. (PubMed id 10803771)⁹ Murata C....Okazaki I. (2000)
429. Genotyping of the aldehyde dehydrogenase 2 (ALDH2) gene using the polymerase chain reaction: evidence for single point mutation in the ALDH2 gene of ALDH2-deficiency. (PubMed id 1916152)⁹ Enomoto N....Date T. (1991)
430. Association of aldehyde dehydrogenase with inheritance of NIDDM. (PubMed id 8877297)⁹ Suzuki Y....Matsuoka K. (1996)
431. Effect of ALDH2 and CYP2E1 gene polymorphisms on drinking behavior and alcoholic liver disease in Japanese male workers. (PubMed id 11410736)⁹ Okamoto K....Kawasaki H. (2001)
432. Suppression of heavy drinking and alcohol seeking by a selective ALDH-2 inhibitor. (PubMed id 19673742)⁹ Arolfo M.P....Diamond I. (2009)
433. RNA interference against aldehyde dehydrogenase-2: development of tools for alcohol research. (PubMed id 19251111)⁹ CortA-nez G....Israel Y. (2009)
434. Attenuation of acetaldehyde-induced cell injury by overexpression of aldehyde dehydrogenase-2 (ALDH2) transgene in human cardiac myocytes: role of MAP kinase signaling. (PubMed id 16403513)⁹ Li S.Y....Ren J. (2006)
435. Simultaneous genotyping of alcohol dehydrogenase 2 (ADH2) and aldehyde dehydrogenase 2 (ALDH2) loci by amplified product length polymorphism (APLP) analysis. (PubMed id 9629893)⁹ Aoshima T....Suzuki T. (1998)
436. [Application of polymerase chain reaction with confronting two-pair primers in aldehyde dehydrogenase-2 typing] (PubMed id 18642666)⁹ Ye X.P....Li L.Q. (2008)
437. Decrease in endogenous CGRP release in nitroglycerin tolerance: role of ALDH-2. (PubMed id 17585900)⁹ Chen Y.R....Li Y.J. (2007)
438. [Effects of ethanol ingestion on glucose tolerance in people with different genotypes of ALDH2] (PubMed id 16316071)⁹ Negoro M....Wakabayashi I. (2005)
439. Overexpression of aldehyde dehydrogenase-2 (ALDH2) transgene prevents acetaldehyde-induced cell injury in human umbilical vein endothelial cells: role of ERK and p38 mitogen-activated protein kinase. (PubMed id 14722101)⁹ Li S.Y....Ren J. (2004)
440. Nucleotide sequence diversity in non-coding regions of ALDH2 as revealed by restriction enzyme and SSCP analysis. (PubMed id 10190330)⁹ Peterson R.J....Long J.C. (1999)
441. Multiple primary esophageal and concurrent upper aerodigestive tract cancer and the aldehyde dehydrogenase-2 genotype of Japanese alcoholics. (PubMed id 8640660)⁹ Yokoyama A....Ishii H. (1996)
442. Polymorphisms of ethanol-oxidizing enzymes in alcoholics with inactive ALDH2. (PubMed id 8834237)⁹ Higuchi S....Hayashida M. (1996)
443. Apparent monomorphism of ALDH2 in seven American Indi an populations. (PubMed id 7772269)⁹ Novoradovsky A.G....Goldman D. (1995)
444. Acetaldehyde metabolism in different aldehyde dehydrogenase-2 genotypes. (PubMed id 2024727)⁹ Enomoto N....Takada A. (1991)
445. Substrate specificity of human and yeast aldehyde dehydrogenases. (PubMed id 18983993)⁹ Wang M.F....Yin S.J. (2009)
446. Single nucleotide polymorphism detection in aldehyde dehydrogenase 2 (ALDH2) gene using bacterial magnetic particles based on dissociation curve analysis. (PubMed id 15329927)⁹ Maruyama K....Matsunaga T. (2004)
447. Hepatitis B and C viruses infection, lifestyle and genetic polymorphisms as risk factors for hepatocellular carcinoma in Haimen, China. (PubMed id 12495467)⁹ Yu S.Z....Tokudome S. (2002)
448. [Classification of alcohol metabolizing enzymes and polymorphisms--specificity in Japanese] (PubMed id 11398342)⁹ Harada S. (2001)
449. Alcohol-related cancers and aldehyde dehydrogenase-2 in Japanese alcoholics. (PubMed id 9744533)⁹ Yokoyama A....Ishii H. (1998)
450. Inhibition of recombinant human mitochondrial and cytosolic aldehyde dehydrogenases by two candidates for the active metabolites of disulfiram. (PubMed id 9354647)⁹ Lam J.P....Lipsky J.J. (1997)
451. Distribution of messenger RNAs for aldehyde dehydrogenase 1, aldehyde dehydrogenase 2, and aldehyde dehydrogenase 5 in human tissues. (PubMed id 8689400)⁹ Stewart M.J....Crabb D.W. (1996)
452. Mitochondrial aldehyde dehydrogenase in diabetes associated with mitochondrial tRNA(Leu(UUR)) mutation at position 3243. (PubMed id 8941476)⁹ Suzuki Y....Matsuoka K. (1996)
453. CYP2E1 and ALDH2 genotypes and alcohol dependence in Japanese. (PubMed id 7573775)⁹ Iwahashi K....Ichikawa Y. (1995)
454. Alcohol and aldehyde dehydrogenase polymorphisms and the risk for alcoholism. (PubMed id 7625477)⁹ Higuchi S....Hayashida M. (1995)
455. Effects of ALDH2, CYP1A1, and CYP2E1 genetic polymorphisms and smoking and drinking habits on toluene metabolism in humans. (PubMed id 7645026)⁹ Kawamoto T....Kodama Y. (1995)
456. Distribution of urinary hippuric acid concentrations by ALDH2 genotype. (PubMed id 7849865)⁹ Kawamoto T....Kodama Y. (1994)
457. Low-Km aldehyde dehydrogenase deficiency does not influence the elevation of blood pressure by alcohol. (PubMed id 8006921)⁹ Okayama A....Kita Y. (1994)
458. [Contribution of the ALDH2 and CYP2E1 genes to flushing response and drinking patterns in Japanese healthy volunteers] (PubMed id 8267522)⁹ Iwahashi K....Orino K. (1993)
459. Activation of aldehyde dehydrogenase-2 reduces ischemic damage to the heart. (PubMed id 18787169)⁹ Chen C.H....Mochly-Rosen D. (2008)
460. Prolonged central sensory conduction time in alcoholics with hypoactive aldehyde dehydrogenase-2. (PubMed id 15380331)⁹ Mochizuki H....Higuchi S. (2004)
461. Genetic deficiency of a mitochondrial aldehyde dehydrogenase increases serum lipid peroxides in community-dwelling females. (PubMed id 12905081)⁹ Ohsawa I....Ohta S. (2003)
462. ALDH2 status, alcohol expectancies, and alcohol respo nse: preliminary evidence for a mediation model. (PubMed id 11707629)⁹ McCarthy D.M....Wall T.L. (2001)
463. Biological markers of alcoholism with respect to genotypes of low-Km aldehyde dehydrogenase (ALDH2) in Japanese subjects. (PubMed id 10803776)⁹ Nomura F....Nakai T. (2000)
464. Aldehyde dehydrogenase (ALDH) 2 associates with oxidation of methoxyacetaldehyde; in vitro analysis with liver subcellular fraction derived from human and Aldh2 gene targeting mouse. (PubMed id 10913633)⁹ Kitagawa K....Nakayama K. (2000)
465. The role of alcohol dehydrogenase 2 and aldehyde dehydrogenase 2 genotypes in alcohol-induced vasospastic angina. (PubMed id 10503603)⁹ Seki T....Kasahara S. (1999)
466. Self-reported alcohol-associated symptoms and drinking behavior in three ALDH2 genotypes among Japanese university students. (PubMed id 10397292)⁹ Takeshita T. and Morimoto K. (1999)
467. Inhibition of recombinant human mitochondrial aldehyde dehydrogenase by two intermediate metabolites of disulfiram. (PubMed id 9605433)⁹ Mays D.C....Lipsky J.J. (1998)
468. Short-term follow-up after endoscopic mucosectomy of early esophageal cancer and aldehyde dehydrogenase-2 genotype in Japanese alcoholics. (PubMed id 9641490)⁹ Yokoyama A....Ishii H. (1998)
469. Study on Parkinson's disease and alcohol drinking. (PubMed id 10028826)⁹ Fujii C....Yoshizawa K. (1998)
470. Simple and rapid determination of the acetaldehyde dehydrogenase (ALDH2) genotypes by nonradioactive single-strand conformation polymorphism analysis. (PubMed id 9420148)⁹ Yuasa I....Irizawa Y. (1997)
471. Reliability of a flushing questionnaire and the ethanol patch test in screening for inactive aldehyde dehydrogenase-2 and alcohol-related cancer risk. (PubMed id 9419411)⁹ Yokoyama A....Ishii H. (1997)
472. Kinetics and specificity of human liver aldehyde dehydrogenases toward aliphatic, aromatic, and fused polycyclic aldehydes. (PubMed id 8605195)⁹ Klyosov A.A. (1996)
473. ALDH2 polymorphism and biological monitoring of toluene. (PubMed id 7944563)⁹ Kawamoto T....Matsuda S. (1994)
474. The relationship between low Km aldehyde dehydrogenase phenotype and drinking behavior in Japanese. (PubMed id 1560668)⁹ Higuchi S....Harford T.C. (1992)
475. The oxidative stress concept of nitrate tolerance and the antioxidant properties of hydralazine. (PubMed id 16226933)⁹ Daiber A....MA1nzel T. (2005)
476. Simultaneous genotyping of alcohol dehydrogenase 2 and aldehyde dehydrogenase 2 by single-strand conformation polymorphism analysis. (PubMed id 14743955)⁹ Sakata R....Fukuda K. (2003)
477. Transcriptional control of the human aldehyde dehydrogenase 2 promoter by hepatocyte nuclear factor 4: inhibition by cyclic AMP and COUP transcription factors. (PubMed id 11811951)⁹ You M....Crabb D. (2002)
478. Synthesis of potential antidipsotropic isoflavones: inhibitors of the mitochondrial monoamine oxidase-aldehyde dehydrogenase pathway. (PubMed id 11563931)⁹ Gao G.Y....Keung W.M. (2001)
479. The effects of the ALDH2*1/2, CYP2E1 C1/C2 and C/D genotypes on blood ethanol elimination. (PubMed id 10826103)⁹ Yoshihara E....Iwahashi K. (2000)
480. Genetic polymorphisms of tobacco- and alcohol-related metabolizing enzymes and human esophageal squamous cell carcinoma susceptibility. (PubMed id 9451664)⁹ Hori H....Yuasa Y. (1997)
481. Alcoholism and alcoholic organ damage and genetic polymorphisms of alcohol metabolizing enzymes in Chinese patients. (PubMed id 8985275)⁹ Chao Y.C....Hsu C.T. (1997)
482. Alcohol-metabolising genes and alcoholism among Taiwanese Han men: independent effect of ADH2, ADH3 and ALDH2. (PubMed id 8773821)⁹ Chen W.J....Cheng A.T. (1996)
483. Characteristics of Japanese alcoholics with the atypical aldehyde dehydrogenase 2*2. I. A comparison of the genotypes of ALDH2, ADH2, ADH3, and cytochrome P-4502E1 between alcoholics and nonalcoholics. (PubMed id 8651462)⁹ Nakamura K....Suwaki H. (1996)
484. Genetic polymorphism of alcohol and aldehyde dehydrogenase and the effects on alcohol metabolism. (PubMed id 8512495)⁹ Yamamoto K....Tatsuno Y. (1993)
485. Cloning and characterization of a new functional human aldehyde dehydrogenase gene. (PubMed id 2061311)⁹ Hsu L.C. and Chang W.-C. (1991)
486. Alcohol drinking, cigarette smoking, and the developm ent of squamous cell carcinoma of the esophagus: epidemiology, clinical finding s, and prevention. (PubMed id 20224884)⁹ Morita M....Maehara Y. (2010)
487. Effects of acetaldehyde inhalation in mitochondrial a ldehyde dehydrogenase deficient mice (Aldh2-/-). (PubMed id 20515806)⁹ Oyama T....Kawamoto T. (2010)
488. Acetaldehyde as a common denominator and cumulative c arcinogen in digestive tract cancers. (PubMed id 19396661)⁹ Salaspuro M. (2009)
489. [The relationship between aldehyde dehydrogenase-2 ge ne polymorphisms and efficacy of nitroglycerin] (PubMed id 17967228)⁹ Zhang H....Zhang Y. (2007)
490. Aldehyde dehydrogenase (ALDH) 3A1 expression by the human keratocyte and its repair phenotypes. (PubMed id 16822507)⁹ Pei Y....McDermott A.M. (2006)
491. Bioelectronic sniffers for ethanol and acetaldehyde in breath air after drinking. (PubMed id 15626611)⁹ Mitsubayashi K....Nakanishi Y. (2005)
492. Paired acute inhalation test reveals that acetaldehyd e toxicity is higher in aldehyde dehydrogenase 2 knockout mice than in wild-typ e mice. (PubMed id 16404141)⁹ Isse T....Kawamoto T. (2005)
493. Risk of multiple squamous cell carcinomas both in the esophagus and the head and neck region. (PubMed id 15718256)⁹ Muto M....Esumi H. (2005)
494. Kimchi and soybean pastes are risk factors of gastric cancer. (PubMed id 15929164)⁹ Nan H.M....Kim H. (2005)
495. Genetic polymorphisms of alcohol and aldehyde dehydrogenases and risk for esophageal and head and neck cancers. (PubMed id 12672787)⁹ Yokoyama A. and Omori T. (2003)
496. Anti-dipsotropic isoflavones: the potential therapeutic agents for alcohol dependence. (PubMed id 12939789)⁹ Keung W.M. (2003)
497. Association of a polymorphism of the serotonin 1B receptor gene and alcohol dependence with inactive aldehyde dehydrogenase-2. (PubMed id 11956970)⁹ Hasegawa Y....Miyaoka H. (2002)
498. Proteomic alterations of the variants of human aldehyde dehydrogenase isozymes correlate with hepatocellular carcinoma. (PubMed id 11774273)⁹ Park K.S....Paik Y.K. (2002)
499. Association between smoking, acetaldehyde dehydrogenase-2 1-1 status, and alcohol drinking among Taiwanese polyvinyl chloride workers. (PubMed id 11515253)⁹ Lin Y.P....Cheng T.J. (2001)
500. [Alcohol and oropharyngolaryngeal and digestive tract cancer] (PubMed id 11828713)⁹ Yokoyama A. and Omori T. (2001)
501. Relationship between alcohol drinking, ADH2 and ALDH2 genotypes, and risk for hepatocellular carcinoma in Japanese. (PubMed id 10737710)⁹ Takeshita T....Morimoto K. (2000)
502. Hangover symptoms in Asian Americans with variations in the aldehyde dehydrogenase (ALDH2) gene. (PubMed id 10627091)⁹ Wall T.L....Carr L.G. (2000)
503. Association of genetic polymorphisms of alcohol-metabolizing enzymes with excessive alcohol consumption in Japanese men. (PubMed id 10543395)⁹ Sun F....Yamada Y. (1999)
504. Genetic polymorphism of aldehyde dehydrogenase 2 in patients with upper aerodigestive tract cancer. (PubMed id 10235272)⁹ Tanabe H....Kohgo Y. (1999)
505. Alcohol and aldehyde dehydrogenase gene polymorphisms influence susceptibility to esophageal cancer in Japanese alcoholics. (PubMed id 10591585)⁹ Yokoyama A....Ishii H. (1999)
506. No association between DRD2 locus and alcoholism after controlling the ADH and ALDH genotypes in Chinese Han population. (PubMed id 10235293)⁹ Lee J.F....Kidd K.K. (1999)
507. Effects of genetic polymorphism of metabolic enzymes, nutrition, and lifestyle factors on DNA adduct formation in lymphocytes. (PubMed id 9810147)⁹ Wang Y....Tomokuni K. (1998)
508. Allele frequency of ADH2 and ALDH2 among Brazilians of different ethnic groups. (PubMed id 9160796)⁹ Santos B.R....Thomasson H.R. (1997)
509. Genotypes of aldehyde dehydrogenase and alcohol dehydrogenase polymorphisms in patients with Leber's hereditary optic neuropathy. (PubMed id 9183998)⁹ Isashiki Y....Ohba N. (1997)
510. Polymorphism of alcohol-metabolizing genes affects drinking behavior and alcoholic liver disease in Japanese men. (PubMed id 9194910)⁹ Tanaka F....Omata M. (1997)
511. Daidzin inhibits mitochondrial aldehyde dehydrogenase and suppresses ethanol intake of Syrian golden hamsters. (PubMed id 9050837)⁹ Keung W.M....Vallee B.L. (1997)
512. Ethanol and acetaldehyde metabolism in chinese with different aldehyde dehydrogenase-2 genotypes. (PubMed id 7480358)⁹ Luu S.U....Yin S.J. (1995)
513. A study on ADH2 and ALDH2 genotyping by PCR-RFLP and SSCP analyses with description of allele and genotype frequencies in Japanese, Finn and Lapp populations. (PubMed id 9063814)⁹ Suzuki K....Fukunaga T. (1994)
514. Polymorphisms of ethanol metabolizing enzyme genes and alcoholism. (PubMed id 8974313)⁹ Higuchi S. (1994)
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516. Involvement of genetic polymorphism of alcohol and aldehyde dehydrogenases in individual variation of alcohol metabolism. (PubMed id 7695788)⁹ Mizoi Y....Harada S. (1994)
517. Biological monitoring of toluene and DNA polymorphism in humans. (PubMed id 8406909)⁹ Kawamoto T....Kodama Y. (1993)
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519. [Aldehyde dehydrogenase activity of blood serum exposed to different concentrations of acetaldehyde] (PubMed id 8160299)⁹ Kharchenko N.K. and Sinitskii V.N. (1993)
520. Identification of human liver aldehyde dehydrogenases that catalyze the oxidation of aldophosphamide and retinaldehyde. (PubMed id 1610409)⁹ Dockham P.A....Sladek N.E. (1992)
521. Distribution of ADH2 and ALDH2 genotypes in different populations. (PubMed id 1733836)⁹ Goedde H.W....Lisker R. (1992)
522. Investigation of the role of polymorphisms at the alcohol and aldehyde dehydrogenase loci in genetic predisposition to alcohol-related end-organ damage. (PubMed id 1937384)⁹ Day C.P....Edenberg H.J. (1991)
523. Nitrate reductase activity of mitochondrial aldehyde dehydrogenase (ALDH-2) as a redox sensor for cardiovascular oxidative stress. (PubMed id 20072908)⁹ Daiber A. and MA1nzel T. (2010)
524. Primate-accelerated evolutionary genes: novel routes to drug discovery in psychiatric disorders. (PubMed id 20166940)⁹ Moalic J.M....Simonneau M. (2010)
525. DNA polymorphism and risk of esophageal squamous cell carcinoma in a population of North Xinjiang, China. (PubMed id 20128036)⁹ Ma W.J....Lu X.M. (2010)
526. The influence of genetic polymorphisms on population variability in six xenobiotic-metabolizing enzymes. (PubMed id 20183525)⁹ Ginsberg G....Sonawane B. (2009)
527. Nitrate tolerance as a model of vascular dysfunction: Roles for mitochondrial aldehyde dehydrogenase and mitochondrial oxidative stress. (PubMed id 19307691)⁹ Daiber A....MA1nzel T. (2009)
528. Mendelian randomization: how it can--and cannot--help confirm causal relations between nutrition and cancer. (PubMed id 19174578)⁹ Schatzkin A....Davey-Smith G. (2009)
529. Single-tube genotyping from a human hair root by dire ct PCR. (PubMed id 20009340)⁹ Hayashida M....Kinoshita K. (2009)
530. Effect of a small dose of alcohol on driving-related behavior of Japanese who self-reported facial flush and nonflushing. (PubMed id 20178264)⁹ Fujita G. and Nishida Y. (2009)
531. Effect of pentachlorophenol and 2,6-dichloro-4-nitrop henol on the activity of cDNA-expressed human alcohol and aldehyde dehydrogenas es. (PubMed id 19822198)⁹ Kollock R....Glatt H. (2009)
532. Demethylbellidifolin prevents nitroglycerin tolerance via improved aldehyde dehydrogenase 2 activity. (PubMed id 19533580)⁹ Shi R.Z....Zhang G.G. (2009)
533. Chronic atrophic gastritis and metachronous gastric cancer in Japanese alcoholic men with esophageal squamous cell carcinoma. (PubMed id 19320631)⁹ Yokoyama A....Maruyama K. (2009)
534. Mitochondrial aldehyde dehydrogenase (ALDH-2)--maker of and marker for nitrate tolerance in response to nitroglycerin treatment. (PubMed id 18834868)⁹ Daiber A....MA1nzel T. (2009)
535. Mitochondrial nitrite reduction coupled to soluble guanylate cyclase activation: lack of evidence for a role in the bioactivation of nitroglycerin. (PubMed id 18951990)⁹ Kollau A....Mayer B. (2009)
536. Human aldehyde dehydrogenase-catalyzed oxidation of ethylene glycol ether aldehydes. (PubMed id 18940187)⁹ Gross A....Sreerama L. (2009)
537. Role of aldehyde dehydrogenase-2 in alcoholic liver disease. (PubMed id 19215230)⁹ Youtz D.J. and Wold L.E. (2009)
538. Involvement of the endothelial DDAH/ADMA pathway in nitroglycerin tolerance: the role of ALDH-2. (PubMed id 18289604)⁹ Zhang G.G....Li Y.J. (2008)
539. The enigma of nitroglycerin bioactivation and nitrate tolerance: news, views and troubles. (PubMed id 18574453)⁹ Mayer B. and Beretta M. (2008)
540. ALDH-2 deficiency increases cardiovascular oxidative stress--evidence for indirect antioxidative properties. (PubMed id 18157936)⁹ Wenzel P....Daiber A. (2008)
541. Prohibitin identified by proteomic analysis of prostate biopsies distinguishes hyperplasia and cancer. (PubMed id 18384941)⁹ Ummanni R....Walther R. (2008)
542. Association between serotonin transporter gene polymorphisms and depressed mood caused by job stress in Japanese workers. (PubMed id 18360696)⁹ Katsuyama H....Sunami S. (2008)
543. New insights into bioactivation of organic nitrates, nitrate tolerance and cross-tolerance. (PubMed id 17938848)⁹ Daiber A....MA1nzel T. (2008)
544. [Recent findings on nitrates: their action, bioactiva tion and development of tolerance] (PubMed id 18946854)⁹ MA1nzel T. (2008)
545. Structure of daidzin, a naturally occurring anti-alcohol-addiction agent, in complex with human mitochondrial aldehyde dehydrogenase. (PubMed id 18613661)⁹ Lowe E.D....Keung W.M. (2008)
546. Pueraria lobata (Kudzu root) hangover remedies and ac etaldehyde-associated neoplasm risk. (PubMed id 17980785)⁹ McGregor N.R. (2007)
547. Inhibition of the oxidative metabolism of 3,4-dihydroxyphenylacetaldehyde, a reactive intermediate of dopamine metabolism, by 4-hydroxy-2-nonenal. (PubMed id 16956664)⁹ Florang V.R....Doorn J.A. (2007)
548. Acetaldehyde, polymorphisms and the cardiovascular system. (PubMed id 17590986)⁹ Yin S.J. and Peng G.S. (2007)
549. Alcohol and airways function in health and disease. (PubMed id 17764883)⁹ Sisson J.H. (2007)
550. Mechanistic implications of the cysteine-nicotinamide adduct in aldehyde dehydrogenase based on quantum mechanical/molecular mechanical simulations. (PubMed id 17655326)⁹ Wymore T....Hempel J. (2007)
551. Ascertainment bias and the pattern of nucleotide diversity at the human ALDH2 locus in a Japanese population. (PubMed id 17225965)⁹ Brown B.T....Wilder J.A. (2007)
552. Removal of acetaldehyde from the body. (PubMed id 17590985)⁹ Deitrich R.A....Vasiliou V. (2007)
553. Oxidative inhibition of the mitochondrial aldehyde dehydrogenase promotes nitroglycerin tolerance in human blood vessels. (PubMed id 18061070)⁹ Hink U....Munzel T. (2007)
554. ALDH2, ADH1B, and ADH1C genotypes in Asians: a literature review. (PubMed id 17718397)⁹ Eng M.Y....Wall T.L. (2007)
555. Genetic polymorphisms and esophageal cancer risk. (PubMed id 17674367)⁹ Hiyama T....Chayama K. (2007)
556. Structural and functional consequences of coenzyme binding to the inactive asian variant of mitochondrial aldehyde dehydrogenase: roles of residues 475 and 487. (PubMed id 17327228)⁹ Larson H.N....Hurley T.D. (2007)
557. Helicobacter pylori, chronic atrophic gastritis, inactive aldehyde dehydrogenase-2, macrocytosis and multiple upper aerodigestive tract cancers and the risk for gastric cancer in alcoholic Japanese men. (PubMed id 17295873)⁹ Yokoyama A....Hibi T. (2007)
558. Effects of acetaldehyde on human airway constriction and inflammation. (PubMed id 17590989)⁹ Matsuse H....Kohno S. (2007)
559. The determination of acetaldehyde in exhaled breath. (PubMed id 17590991)⁹ Tardif R. (2007)
560. The genetics of alcohol metabolism: role of alcohol dehydrogenase and aldehyde dehydrogenase variants. (PubMed id 17718394)⁹ Edenberg H.J. (2007)
561. Differential actions of the proneural genes encoding Mash1 and neurogenins in Nurr1-induced dopamine neuron differentiation. (PubMed id 16723737)⁹ Park C.H....Lee S.H. (2006)
562. Dysfunction of mitochondria and oxidative stress in the pathogenesis of Alzheimer's disease: on defects in the cytochrome c oxidase complex and aldehyde detoxification. (PubMed id 16873963)⁹ Ohta S. and Ohsawa I. (2006)
563. Mechanisms of alcohol-induced hepatic fibrosis: a summary of the Ron Thurman Symposium. (PubMed id 16502397)⁹ Purohit V. and Brenner D.A. (2006)
564. Complex I dysfunction and tolerance to nitroglycerin: an approach based on mitochondrial-targeted antioxidants. (PubMed id 17053193)⁹ Esplugues J.V....Victor V.M. (2006)
565. Inhibition of human mitochondrial aldehyde dehydrogenase by 4-hydroxynon-2-enal and 4-oxonon-2-enal. (PubMed id 16411662)⁹ Doorn J.A....Petersen D.R. (2006)
566. Identification of human liver mitochondrial aldehyde dehydrogenase as a potential target for microcystin-LR. (PubMed id 16413648)⁹ Chen T....Shen P. (2006)
567. Evaluation in vinyl chloride monomer-exposed workers and the relationship between liver lesions and gene polymorphisms of metabolic enzymes. (PubMed id 16270392)⁹ Zhu S.M....Xia Z.L. (2005)
568. Hydralazine is a powerful inhibitor of peroxynitrite formation as a possible explanation for its beneficial effects on prognosis in patients with congestive heart failure. (PubMed id 16289107)⁹ Daiber A....Tsilimingas N. (2005)
569. Differential effects of Mg2+ ions on the individual kinetic steps of human cytosolic and mitochondrial aldehyde dehydrogenases. (PubMed id 15924421)⁹ Ho K.K....Weiner H. (2005)
570. Epidemiological evidence that acetaldehyde plays a si gnificant role in the development of decreased serum folate concentration and e levated mean corpuscular volume in alcohol drinkers. (PubMed id 15834228)⁹ Yokoyama T....Tanaka H. (2005)
571. Ebrii gignunt ebrios--One drunkard begets another: the genetics of alcohol dependence. (PubMed id 15802091)⁹ Ball D. (2005)
572. Overview of the role of alcohol dehydrogenase and aldehyde dehydrogenase and their variants in the genesis of alcohol-related pathology. (PubMed id 15099407)⁹ Crabb D.W....You M. (2004)
573. Biological and behavioral markers of alcohol sensitivity. (PubMed id 15112932)⁹ Fromme K....Goldman D. (2004)
574. [Aldehyde dehydrogenase (ALDH2) polymorphism and drinking behavior.] (PubMed id 15639999)⁹ Luo H.R. and Zhang Y.P. (2004)
575. Differential responses of serum gamma-glutamyltransferase to alcohol intake in Japanese males. (PubMed id 14627068)⁹ Matsuka Y....Kira S. (2003)
576. Evaluation of a microarray for genotyping polymorphisms related to xenobiotic metabolism and DNA repair. (PubMed id 14579748)⁹ Landi S....Canzian F. (2003)
577. Purification and characterization of two distinct aldehyde-oxidizing enzymes from the liver of black seabream. (PubMed id 12604200)⁹ Fong W.P....Tang W.K. (2003)
578. Inactivation of betaine aldehyde dehydrogenase from Pseudomonas aeruginosa and Amaranthus hypochondriacus L. leaves by disulfiram. (PubMed id 12604199)⁹ Velasco-GarcA-a R....MuA+oz-Clares R.A. (2003)
579. Species variations in cutaneous alcohol dehydrogenases and aldehyde dehydrogenases may impact on toxicological assessments of alcohols and aldehydes. (PubMed id 12499113)⁹ Cheung C....Smith Pease C.K. (2003)
580. The ADH3*2 and CYP2E1 c2 alleles increase the risk of alcoholism in Mexican American men. (PubMed id 12710951)⁹ Konishi T....Wan Y.J. (2003)
581. Synthesis of daidzin analogues as potential agents for alcohol abuse. (PubMed id 12927869)⁹ Gao G.Y....Keung W.M. (2003)
582. Population distribution of aldehyde dehydrogenase-2 genetic polymorphism: implications for risk assessment. (PubMed id 12473414)⁹ Ginsberg G....Sonawane B. (2002)
583. Why can't Chinese Han drink alcohol? Hepatitis B virus infection and the evolution of acetaldehyde dehydrogenase deficiency. (PubMed id 12208210)⁹ Lin Y.P. and Cheng T.J. (2002)
584. The effects of low Km aldehyde dehydrogenase (ALDH2) phenotype on drinking behavior in Japanese university students. (PubMed id 12380847)⁹ Sobue I....Morimoto K. (2002)
585. Alcohol and retinoids. (PubMed id 11391073)⁹ Crabb D.W....Bode C. (2001)
586. ADH2 and alcohol-related phenotypes in Ashkenazic Jewish American college students. (PubMed id 11545539)⁹ Shea S.H....Li T.K. (2001)
587. Genetic dissection of retinoid dehydrogenases. (PubMed id 11306068)⁹ Duester G. (2001)
588. Order and disorder in mitochondrial aldehyde dehydrogenase. (PubMed id 11306026)⁹ Hurley T.D....Breen H. (2001)
589. Alcohol and cancer. (PubMed id 11391063)⁹ Seitz H.K....Wang X.D. (2001)
590. The ALDH2 genotype, alcohol intake, and liver-function biomarkers among Japanese male workers. (PubMed id 10942105)⁹ Takeshita T....Morimoto K. (2000)
591. Polymorphisms of human aldehyde dehydrogenases. Consequences for drug metabolism and disease. (PubMed id 10971205)⁹ Vasiliou V. and Pappa A. (2000)
592. Deficiency in mitochondrial aldehyde dehydrogenase increases the risk for late-onset Alzheimer's disease in the Japanese population. (PubMed id 10873585)⁹ Kamino K....Ohta S. (2000)
593. Genetic polymorphism of enzymes involved in xenobiotic metabolism and the risk of colorectal cancer. (PubMed id 11059519)⁹ Kiyohara C. (2000)
594. Accumulation of hemoglobin-associated acetaldehyde with habitual alcohol drinking in the atypical ALDH2 genotype. (PubMed id 10656185)⁹ Takeshita T. and Morimoto K. (2000)
595. Cooperativity in nicotinamide adenine dinucleotide binding induced by mutations of arginine 475 located at the subunit interface in the human liver mitochondrial class 2 aldehyde dehydrogenase. (PubMed id 10819999)⁹ Wei B....Weiner H. (2000)
596. [Biomarkers of gentotoxic risk and metabolic polymorphism] (PubMed id 11189784)⁹ Pavanello S. and Clonfero E. (2000)
597. Metabolism of retinaldehyde and other aldehydes in soluble extracts of human liver and kidney. (PubMed id 10559215)⁹ Ambroziak W....Pietruszko R. (1999)
598. Blood and urinary levels of ethanol, acetaldehyde, an d C4 compounds such as diacetyl, acetoin, and 2,3-butanediol in normal male stu dents after ethanol ingestion. (PubMed id 10064379)⁹ Otsuka M....Ohmori S. (1999)
599. Evidence for ethanol oxidation by Kupffer cells. (PubMed id 10235287)⁹ Nakamura Y....Ishii H. (1999)
600. An examination of ALDH2 genotypes, alcohol metabolism and the flushing response in Native Americans. (PubMed id 10091951)⁹ Gill K....Deitrich R.A. (1999)
601. Evaluation of the self-rating of the effects of alcohol form in Asian Americans with aldehyde dehydrogenase polymorphisms. (PubMed id 10606490)⁹ Wall T.L....Schuckit M.A. (1999)
602. Activity of the human aldehyde dehydrogenase 2 promoter is influenced by the balance between activation by hepatocyte nuclear factor 4 and repression by perosixome proliferator activated receptor delta, chicken ovalbumin upstream promoter-transcription factor, and apolipoprotein regulatory protein-1. (PubMed id 10352676)⁹ Pinaire J....Crabb D. (1999)
603. Genetic polymorphisms of tobacco- and alcohol-related metabolizing enzymes and oral cavity cancer. (PubMed id 10521794)⁹ Katoh T....Kawamoto T. (1999)
604. Genotype difference of aldehyde dehydrogenase 2 gene in alcohol drinkers influences the incidence of Japanese colorectal cancer patients. (PubMed id 10470282)⁹ Murata M....Morimoto K. (1999)
605. Genotypes of alcohol-metabolizing enzymes in relation to alcoholic chronic pancreatitis in Japan. (PubMed id 10235286)⁹ Maruyama K....Matsuno M. (1999)
606. Differences in the roles of conserved glutamic acid residues in the active site of human class 3 and class 2 aldehyde dehydrogenases. (PubMed id 10548037)⁹ Mann C.J. and Weiner H. (1999)
607. Human aldehyde dehydrogenase gene family. (PubMed id 9490025)⁹ Yoshida A....Chang C. (1998)
608. Clinical characteristics and disease course of alcoholics with inactive aldehyde dehydrogenase-2. (PubMed id 9581663)⁹ Murayama M....Higuchi S. (1998)
609. Genetic polymorphism of CYP2E1, ADH2, and ALDH2 in Mexican-Americans. (PubMed id 10464602)⁹ Wan Y.J....Lin K.M. (1998)
610. Effects on sister chromatid exchange frequency of aldehyde dehydrogenase 2 genotype and smoking in vinyl chloride workers. (PubMed id 9838066)⁹ Wong R.H....Cheng T.J. (1998)
611. Studies on the enzymology of aldehyde dehydrogenase-2 in genetically modified HeLa cells. (PubMed id 9660300)⁹ Crabb D. and Xiao Q. (1998)
612. Development of a questionnaire method to discriminate between typical and atypical genotypes of low Km aldehyde dehydrogenase in a Japanese population. (PubMed id 9802521)⁹ Takeshita T. and Morimoto K. (1998)
613. [Analysis of flushing response to alcohol and drinking behavior in Japanese male students] (PubMed id 9102476)⁹ Sobue I....Morimoto K. (1997)
614. Alcohol dehydrogenase and aldehyde dehydrogenase genotypes and alcoholism among Taiwanese aborigines. (PubMed id 9066994)⁹ Chen W.J....Cheng A.T. (1997)
615. Involvement of glutamate 399 and lysine 192 in the mechanism of human liver mitochondrial aldehyde dehydrogenase. (PubMed id 9228057)⁹ Ni L....Weiner H. (1997)
616. Genetic characterization of the bovine leukaemia inhibitory factor (LIF) gene: isolation and sequencing, chromosome assignment and microsatellite analysis. (PubMed id 9124702)⁹ Piedrahita J.A....Womack J.E. (1997)
617. Elevated levels of hemoglobin-associated acetaldehyde related to alcohol drinking in the atypical genotype of low Km aldehyde dehydrogenase. (PubMed id 9102206)⁹ Takeshita T....Morimoto K. (1997)
618. Heterotetramers of human liver mitochondrial (class 2) aldehyde dehydrogenase expressed in Escherichia coli. A model to study the heterotetramers expected to be found in Oriental people. (PubMed id 8940116)⁹ Wang X....Weiner H. (1996)
619. Hepatocellular carcinoma associated with alcoholic liver disease: a clinicopathological study and genetic polymorphism of aldehyde dehydrogenase 2. (PubMed id 8986242)⁹ Ohhira M....Kohgo Y. (1996)
620. High incidence of ADH2*1/ALDH2*1 genes among Japanese alcohol dependents and patients with alcoholic liver disease. (PubMed id 8591846)⁹ Tanaka F....Omata M. (1996)
621. Cancer screening of upper aerodigestive tract in Japanese alcoholics with reference to drinking and smoking habits and aldehyde dehydrogenase-2 genotype. (PubMed id 8903472)⁹ Yokoyama A....Ishii H. (1996)
622. Genotypes of alcohol-metabolizing enzymes and the risk for alcoholic chronic pancreatitis in Japanese alcoholics. (PubMed id 8986224)⁹ Matsumoto M....Ishii H. (1996)
623. Low Km aldehyde dehydrogenase (ALDH2) polymorphism, alcohol-drinking behavior, and chromosome alterations in peripheral lymphocytes. (PubMed id 8781384)⁹ Morimoto K. and Takeshita T. (1996)
624. No evidence of association between structural polymorphism at the dopamine D3 receptor locus and alcoholism in the Japanese. (PubMed id 8837712)⁹ Higuchi S....Murayama M. (1996)
625. Esophageal cancer and aldehyde dehydrogenase-2 genoty pes in Japanese males. (PubMed id 8850269)⁹ Yokoyama A....Ishii H. (1996)
626. Alcohol and aldehyde dehydrogenase genotypes and drinking behavior in Japanese. (PubMed id 8727242)⁹ Higuchi S....Hayashida M. (1996)
627. Habitual and genetic factors that affect urinary background levels of biomarkers for organic solvent exposure. (PubMed id 8579380)⁹ Kawamoto T....Kodama Y. (1996)
628. Involvement of glutamate 268 in the active site of human liver mitochondrial (class 2) aldehyde dehydrogenase as probed by site-directed mutagenesis. (PubMed id 7819202)⁹ Wang X. and Weiner H. (1995)
629. Genotypes of alcohol-metabolizing enzymes in Mexicans with alcoholic liver cirrhosis. (PubMed id 8845660)⁹ Lisker-Yourkowitzky R....Mutchinick-Baringoltz O. (1995)
630. Acute effects of alcohol on P300 in Asians with different ALDH2 genotypes. (PubMed id 7573783)⁹ Wall T.L. and Ehlers C.L. (1995)
631. The novel aldehyde dehydrogenase gene, ALDH5, encodes an active aldehyde dehydrogenase enzyme. (PubMed id 7779080)⁹ Stewart M.J....Crabb D.W. (1995)
632. Polymorphisms in alcohol metabolizing enzyme genes and alcoholic cirrhosis in Japanese patients: a multivariate analysis. (PubMed id 7557863)⁹ Yamauchi M....Toda G. (1995)
633. Dopamine transporter gene polymorphism and alcoholism. (PubMed id 7779096)⁹ Muramatsu T. and Higuchi S. (1995)
634. Alcohol-metabolizing enzyme polymorphisms and alcoholism in Japan. (PubMed id 7485844)⁹ Maezawa Y....Sakurai S. (1995)
635. Polymorphism in ALDH2-genotype in Japanese men and the alcohol-blood pressure relationship. (PubMed id 8554727)⁹ Tsuritani I....Yamada Y. (1995)
636. Measuring and reporting the concentration of acetaldehyde in human breath. (PubMed id 7545981)⁹ Jones A.W. (1995)
637. CYP2E1 genotypes and serum LAP in Japanese alcoholics. (PubMed id 9001446)⁹ Miyatake R....Iwahashi K. (1995)
638. Polymorphism of a class 3 aldehyde dehydrogenase present in human saliva and in hair roots. (PubMed id 7625577)⁹ Dyck L.E. (1995)
639. Therapeutic lessons from traditional Oriental medicine to contemporary Occidental pharmacology. (PubMed id 8032168)⁹ Keung W.M. and Vallee B.L. (1994)
640. Cloning and characterization of the gene encoding mouse mitochondrial aldehyde dehydrogenase. (PubMed id 7958964)⁹ Chang C. and Yoshida A. (1994)
641. Analysis of the genotypes for aldehyde dehydrogenase 2 in Japanese patients with primary gout. (PubMed id 7660963)⁹ Yamanaka H....Kashiwazaki S. (1994)
642. Characterization of the three genotypes of low Km aldehyde dehydrogenase in a Japanese population. (PubMed id 8076934)⁹ Takeshita T....Furuyama J. (1994)
643. [Rationale for alcohol consumption and mitochondrial aldehyde dehydrogenase genotype in the native male population of Chukotka] (PubMed id 7513575)⁹ Kurilovich S.A....Daffi L. (1994)
644. Low frequency of the ADH2*2 allele among Atayal natives of Taiwan with alcohol use disorders. (PubMed id 7943668)⁹ Thomasson H.R....Yin S.J. (1994)
645. Genotypes of ALDH2 related to liver and pulmonary diseases and other genetic factors related to alcoholic liver disease. (PubMed id 7695791)⁹ Takada A....Kobayashi Y. (1994)