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ALDH2 Gene

protein-coding GIFtS: 72

GC12P110667

aldehyde dehydrogenase 2 family (mitochondrial)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
ALDH-E2 ^², ³
ALDHI ^², ³
ALDM ^², ³
EC 1.2.1.3 ^³
MGC1806 ^²

Descriptions
ALDH class 2 ^², ³
acetaldehyde dehydrogenase 2 ^²
aldehyde dehydrogenase 2 family (mitochondrial) ^²
liver mitochondrial ALDH ^²
mitochondrial aldehyde dehydrogenase 2 ^²
nucleus-encoded mitochondrial aldehyde dehydrogenase 2 ^²

External Ids
HGNC: 404¹
Entrez Gene: 217²
UniProtKB: P05091³
Ensembl: ENSG00000111275⁷

Search outside databases for aliases for ALDH2 gene

Previous GC identifers: GC12P111101 GC12P111726 GC12P111987 GC12P110616

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ALDH2:

This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is

the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms

of this enzyme, cytosolic and mitochondrial, can be distinguished by their electrophoretic

mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major

isozymes, while approximately 50% of Orientals have only the cytosolic isozyme, missing the

mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals

than among Caucasians could be related to the absence of the mitochondrial isozyme. This gene

encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in

mitochondrial matrix. [provided by RefSeq]

Gene Wiki entry for ALDH2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ALDH2 gene

Entrez Gene cytogenetic band: 12q24.2 Ensembl cytogenetic band: 12q24.12 HGNC cytogenetic band: 12q24.12

ALDH2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12P110667: (about GC identifiers)

Start:	110,688,729 bp from pter
End:	110,732,167 bp from pter
Size:	43,439 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000012.10 NT_009775.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: ALDH2_HUMAN, P05091 (See protein sequence)

Recommended Name: Aldehyde dehydrogenase, mitochondrial precursor

Size: 517 amino acids; 56381 Da

Subunit: Homotetramer

Subcellular location: Mitochondrion matrix

Sequence caution: Sequence=AAA62825.1; Type=Frameshift; Positions=424, 444, 448, 461;

Sequence=CAA68290.1; Type=Frameshift; Positions=Several; Sequence=CAA68290.1; Type=Miscellaneous

discrepancy;

PDB structures from and Proteopedia :

1CW3 (3D)

1NZW (3D)

1NZX (3D)

1NZZ (3D)

1O00 (3D)

1O01 (3D)

1O02 (3D)

1O04 (3D)

1O05 (3D)

1ZUM (3D)

2ONM (3D)

2ONN (3D)

2ONO (3D)

2ONP (3D)

2VLE (3D)

Secondary accessions: Q03639 Q6IB13 Q6IV71

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_000681.2

ENSEMBL proteins:

ENSP00000261733

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (ALDH2)
	Human Recombinant Proteins from Abnova (ALDH3)

OriGene Purified Recombinant Human Protein: ALDH2

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005739	mitochondrion	IEA	--
GO:0005759	mitochondrial matrix	IEA	--

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Antibodies for ALDH2:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for ALDH2
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (ALDH2), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ALDH3)
	Novus Biologicals Antibodies for ALDH2

Assays for ALDH2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P05091

ProtoNet protein and cluster: P05091

2 Blocks protein families:

IPB001484 Pyrokinin

IPB002086 Aldehyde dehydrogenase

UniProtKB/Swiss-Prot: ALDH2_HUMAN, P05091

Similarity: Belongs to the aldehyde dehydrogenase family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ALDH2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ALDH3)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000690

Applied Biosystems Silencer® siRNAs for ALDH2

Sigma-Aldrich siRNA and siRNA Panels for ALDH2

Sigma-Aldrich shRNA for ALDH2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ALDH2
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000690
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000690
untagged cDNA clone in CMV expression vector: NM_000690

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000690

UniProtKB/Swiss-Prot: ALDH2_HUMAN, P05091

Catalytic activity: An aldehyde + NAD(+) + H(2)O = an acid + NADH

Enzyme Number (IUBMB): EC 1.2.1.3

Genatlas biochemistry entry for ALDH2:

aldehyde dehydrogenase 2,mitochondrial,E2 isoform

2 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Aldh2):

cellular

homeostasis/metabolism

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004029	aldehyde dehydrogenase (NAD) activity	TAS	1306115
GO:0004030	aldehyde dehydrogenase [NAD(P)+] activity	TAS	8903321
GO:0009055	electron carrier activity	TAS	8903321
GO:0016491	oxidoreductase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/17 Sigma-Aldrich "Your Favorite Gene" Pathways for ALDH2 (Your Favorite Gene powered by Ingenuity) (see all 17 )

Tyrosine Metabolism
Glycolysis/Gluconeogenesis
Propanoate Metabolism
Ascorbate and Aldarate Metabolism
&beta

GeneDecks ALDH2 for the pathways selected above

About GeneDecksing

UniProtKB/Swiss-Prot: ALDH2_HUMAN, P05091

Pathway: Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2

Gene Network Central^TM Interacting Genes and Proteins Network for ALDH2

5/100 Interacting proteins for ALDH2 (ENSP00000261733³ P05091²) via UniProtKB, MINT, and/or STRING (see all 100 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
C14orf1	Q9UKR5²	MINT-63389
CRMP1	Q14194²	MINT-63386
IGSF21	Q96ID5²	MINT-63387
UNC119	Q13432²	MINT-63385
ADH1B	ENSP00000306606³	STRING (score=.996)

About this table

3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005975	carbohydrate metabolic process	TAS	8903321
GO:0006066	cellular alcohol metabolic process	TAS	1306115
GO:0055114	oxidation reduction	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Sigma-Aldrich Small Molecules for ALDH2:

Blocker

Browse Tocris compounds for ALDH2
10/33 Novoseek chemical compound relationships for ALDH2 gene (see all 33 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
ethanol	75.23	112	19144977 (4), 16316071 (3), 10826103 (3), 8512495 (3) (see all 54)
propionaldehyde	68.62	2	15703303 (1), 17655326 (1)
retinaldehyde	63.29	1	10559215 (1)
aldophosphamide	62.01	2	1610409 (2)
rsai	59.54	2	15318112 (1), 11696658 (1)
betaine aldehyde	56.53	1	1527093 (1)
vinylchloride	55.12	19	12739102 (4), 17384900 (2), 12705718 (2), 17659824 (1) (see all 5)
nad+	50.69	7	8433985 (1), 11306026 (1), 17327228 (1), 18983993 (1) (see all 6)
benzaldehyde	48.08	1	18061070 (1)
decanal	46.82	1	8605195 (1)

About this table

2 PharmGKB drug compound relationships for ALDH2 gene

Drug compound	PharmGKB Relations	PubMed IDs for articles supporting these relationships
ethanol	PD GN	9194910
vinyl chloride	PD GN	9838066

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ALDH2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ALDH3)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000690

Sigma-Aldrich siRNA and siRNA Panels for ALDH2

Sigma-Aldrich shRNA for ALDH2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000690

REFSEQ mRNAs for ALDH2 gene:

NM_000690.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000690

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000690
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000690
                                 untagged cDNA clone in CMV expression vector: NM_000690

Additional cDNA sequence:

AK223373.1 AK301375.1 AK314856.1 AY621070.1 BC002967.1 BC071839.1 BC127796.1 CR456991.1

CR609508.1 CR617194.1 CR618953.1 CR620819.1 K03001.1 M26760.1 M54931.1 S80262.1

X05409.1 Y00109.1

24 DOTS entries:

DT.100825560 DT.219231 DT.100825566 DT.100825563 DT.100030509 DT.100825574 DT.92458180 DT.95159151

DT.100825577 DT.121177828 DT.92458189 DT.95159142 DT.95159145 DT.100825568 DT.121177818 DT.121177839

DT.92458178 DT.95159116 DT.100825562 DT.121177767 DT.121177793 DT.95159148 DT.92018440 DT.92458173

24/651 AceView cDNA sequences (see all 651 ):

AL043850 AA715095 W17229 AI751738 AA923050 BU151478 BU849300 AL043849

BM782514 BM980181 AK097425 BU186773 AV650553 CF456426 AA419072 BM765605

BQ933288 AA316218 AL532964 BU607893 BI491284 M26760 BM784297 BU174018

highest scoring ESTs for ALDH2:

X05409 AA012947 AA017217 AA021588 AA191502 AA322407 AA384097 AA394012 AA410613 AA419072

Unigene Cluster for ALDH2:

Aldehyde dehydrogenase 2 family (mitochondrial)

Hs.632733 [show with all ESTs]

Unigene Representative Sequence: NM_000690

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for ALDH2

ExUns:	1a	·	1b	^	2	^	3	^	4a	·	4b	^	5	^	6a	·	6b	^	7	^	8	^	9	^	10a	·	10b	^	11	^	12	^	13	^	14a	·	14b	·	14c
SP1:
SP2:					-
SP3:					-						-		-		-
SP4:																															-

About this scheme

ECgene alternative splicing isoforms for ALDH2

1 Ensembl transcript including schematic representation:

ENST00000261733

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ALDH2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ALDH2

¹ / ² / ³

3 probe-sets matching ALDH2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
32747_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	X05409	1.00	0.90	0.95	1
201425_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000690	0.60	0.83	0.73	1
201425_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GTGGGTTGGC

SOURCE GeneReport for Unigene cluster: Hs.632733
Expression variation in blood from EXPOLDB for ALDH2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ALDH2 gene from 5/17 species (see all 17 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ALDH2¹	--	aldehyde dehydrogenase 2 family (mitochondrial)	88.91(n) 94.16(a)	610941 XM_848535.1 XP_853628.1
chimpanzee (Pan troglodytes)	ALDH2¹	--	aldehyde dehydrogenase 2 family (mitochondrial)	98.78(n) 98.86(a)	452252 XM_509379.2 XP_509379.2
cow (Bos taurus)	ALDH2¹	--	aldehyde dehydrogenase 2 family (mitochondrial)	89.47(n) 93.96(a)	508629 NM_001075367.1 NP_001068835.1
rat (Rattus norvegicus)	Aldh2¹	--	aldehyde dehydrogenase 2 family (mitochondrial)	88.24(n) 96.12(a)	29539 NM_032416.1 NP_115792.1
mouse (Mus musculus)	Aldh2^{1, 5}	5⁵	aldehyde dehydrogenase 2, mitochondrial^{1, 5}	86.82(n)¹ 95.54(a)¹	11669¹ NM_009656.3¹ NP_033786.1¹ AK035145⁵ AK042326⁵ (see all 38)

About this table Species with no ortholog for ALDH2

ENSEMBL Gene Tree for ALDH2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ALDH2 gene

ALDH1B1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

UniProtKB/Swiss-Prot: ALDH2_HUMAN, P05091

Polymorphism: Allele ALDH2*2 is associated with a very high incidence of acute alcohol intoxication

in Orientals and South American Indians, as compared to Caucasians

10/181 NCBI SNPs in ALDH2 are shown (see all 181 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 44)

AB	SNP ID	Valid	Chr 12 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs886205^1,2	A,C,F,H	110688810(-)	`GACCTT/CCCCGG`	1	--	ut5¹		20		MN EU CSAM EA NA WA	2010
	rs671^1,2	C,F,H	110726149(+)	`ACACTG/AAAGTG`	1	K/E	mis¹ ese³		18		MN CSAM EA CA EU WA NA	1524
	rs1062136^1,2	F,H	110714896(+)	`TGTGGA/TGCGGA`	1	E/V	mis¹ ese³		5		MN EU EA WA	596
--	rs7136890^1,2	A	110688328(+)	`gcaggC/Tgcctg`	1	--	ng5¹		0	--	--	--	--
	rs13306164^1,2	F,H	110705438(+)	`GGCTGC/TTGAAC`	1	L/L	syn¹ ese³		4		EU EA WA	420
--	rs6490301^1,2	A,C	110689178(+)	`TTGCGC/TGCTGC`	1	R/R	syn¹ ese³		0	--	--	--	--
	rs2238151^1,2	A,C,F,H,O	110696216(+)	`CTGGCC/TCAGGG`	1	--	int¹		19		EA EU NA WA MN CSAM	3120
	rs968529^1,2	A,C,F,H	110718751(+)	`TCCATC/TGGTAA`	1	--	int¹		7		EU EA WA NA	562
	rs7296651^1,2	A,C,F,H	110731337(+)	`TAACTG/CTTCAT`	1	--	int¹		11		EU EA WA NA	974
	rs10744777^1,2	A,C,F,H	110717401(+)	`TTTTCC/TATTAA`	1	--	int¹		8		EU EA WA	834

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HapMap Linkage Disequilibrium images for ALDH2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 100650

UniProtKB/Swiss-Prot: ALDH2_HUMAN, P05091

Defects in ALDH2 are a cause of acute alcohol sensitivity [MIM:610251]. There are wide

individual differences in responses to drinking alcohol. Recent estimates claim that subjective

effects (how people feel when they drink) vary from 200%-300% in the adult population, and ethanol

metabolism (how quickly alcohol is absorbed into the bloodstream and metabolized by the liver)

varies by approximately 200%. Unfortunately, alcohol researchers know very little about why such

drastic differences occur between individuals and how individual differences in alcohol

sensitivity might link drinking behavior with problematic alcohol-related outcomes

10/54 Novoseek disease relationships for ALDH2 gene (see all 54 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
alcoholism	82.96	113	7625477 (5), 10803776 (4), 1492799 (4), 7573775 (3) (see all 53)
liver diseases alcoholic	66.51	20	11410736 (5), 15519646 (2), 8986242 (1), 8591846 (1) (see all 10)
pancreatitis alcoholic	61.90	7	11117576 (2), 8985275 (1), 8986224 (1), 10235286 (1) (see all 5)
alcohol abuse	58.21	2	19251111 (1)
alcoholic cirrhosis	56.31	7	12824748 (1), 15220553 (1), 8845660 (1), 11748356 (1) (see all 5)
alcoholic neuropathy	53.47	3	15182962 (2), 15542751 (1)
macrocytosis	52.25	2	16759795 (1), 17295873 (1)
smoking habit	44.14	9	15714130 (3), 18216179 (2), 8903472 (2), 17207821 (1)
carcinoma squamous cell	40.82	17	16759795 (2), 16639733 (2), 12223435 (2), 18322963 (2) (see all 11)
chronic pancreatitis	40.53	8	17454860 (2), 18773092 (1), 19096130 (1), 11966948 (1) (see all 6)

About this table

2 PharmGKB disease relationships for ALDH2 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Liver Diseases, Alcoholic	PD GN	9194910
Neoplasms	PD GN	9838066

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Genatlas disease: ALDH2

facial flushing reaction to alcohol

Human Gene Mutation Database: ALDH2
Genetic Association Database: ALDH2
Human Genome Epidemiology Navigator: ALDH2 (226 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/491 PubMed articles for ALDH2 gene (see all 491 ):

Cloning of cDNAs for human aldehyde dehydrogenases 1 and 2. (PubMed id 2987944)^{2, 3, 4} Hsu L.C....Yoshida A. (1985)
Molecular abnormality and cDNA cloning of human aldehyde dehydrogenases. (PubMed id 4015823)^{2, 3, 4} Yoshida A.... Tani K. (1985)
Aldehyde dehydrogenase 2 and beta3-adrenergic receptor gene polymorphisms: their association with elevated liver enzymes and metabolic syndrome. (PubMed id 14506613)^{1, 3, 6} Murata C....Okazaki I. (2003)
[Effects of genetic polymorphisms of ethanol-metabolizing enzymes on alcohol drinking behaviors] (PubMed id 12824748)^{1, 3, 6} Kee J.Y....Chae H.B. (2003)
[Polymorphism of alcohol metabolizing-related enzyme genes and its correlation with drinking-behaviors in 201 cases of Chinese Han healthy population.] (PubMed id 15842823)^{1, 3, 6} Cao X.R. and Wu D.S. (2005)
Effects of ALDH2 gene polymorphisms and alcohol-drinking behavior on micronuclei frequency in non-smokers. (PubMed id 14568296)^{1, 3, 6} Ishikawa H....Yokoyama K. (2003)
Genetic polymorphisms of aldehyde dehydrogenase 2, cytochrome p450 2E1 for liver cancer risk in HCV antibody-positive japanese patients and the variations of CYP2E1 mRNA expression levels in the liver due to its polymorphism. (PubMed id 12940444)^{1, 3, 6} Kato S....Naito Z. (2003)
Alcoholism, ALDH2*2 allele and the A1 allele of the dopamine D2 receptor gene: an association study. (PubMed id 11600186)^{1, 3, 6} Matsushita S....Higuchi S. (2001)
ALDH2 and CYP2E1 genotypes, urinary acetaldehyde excretion and the health consequences in moderate alcohol consumers. (PubMed id 16365683)^{1, 3, 6} Yamada Y....Honda R. (2006)
Effects of dietary intake and genetic factors on hypermethylation of the hMLH1 gene promoter in gastric cancer. (PubMed id 15991278)^{1, 3, 6} Nan H.M....Kim H. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 217	HGNC: 404	AceView: ALDH2andACAD10	Ensembl:ENSG00000111275	euGenes: HUgn217
ECgene: ALDH2	H-InvDB: ALDH2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for ALDH2	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for ALDH2
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ALDH2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ALDH2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ALDH2		Antibodies for ALDH2
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ALDH2		Small molecules for ALDH2
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (ALDH3)
	Antibodies (ALDH3)
	Chimera RNAi (ALDH3)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (ALDH2)
	Antibodies (ALDH2)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for ALDH2

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for ALDH2

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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ALDH2 Gene at Home site.
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ALDH2 Gene

protein-coding GIFtS: 72

Aliases &
Descriptions
for ALDH2

Summaries
for ALDH2

Genomic Location
for ALDH2

Proteins
for ALDH2

Protein Domains/
Families
for ALDH2

Gene Function
for ALDH2

Pathways & Interactions
for ALDH2

Drugs & Compounds
for ALDH2

Transcripts
for ALDH2

Expression
for ALDH2

Orthologs
for ALDH2

Paralogs
for ALDH2

SNPs/Variants
for ALDH2

Disorders & Mutations
for ALDH2

Medical News
for ALDH2

Publications
for ALDH2

Search for ALDH2

Genome Databases showing ALDH2

Other Databases showing ALDH2

Specialized Databases showing ALDH2

Licensable Technologies
for ALDH2

Services
for ALDH2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ALDH2 Gene

protein-coding GIFtS: 72

Aliases & Descriptionsfor ALDH2

Summariesfor ALDH2

Genomic Locationfor ALDH2

Proteinsfor ALDH2

Protein Domains/Familiesfor ALDH2

Gene Functionfor ALDH2

Pathways & Interactionsfor ALDH2

Drugs & Compoundsfor ALDH2

Transcriptsfor ALDH2

Expression for ALDH2

Orthologsfor ALDH2

Paralogsfor ALDH2

SNPs/Variantsfor ALDH2

Disorders & Mutationsfor ALDH2

Medical Newsfor ALDH2

Publicationsfor ALDH2

Search for ALDH2

Genome Databases showing ALDH2

Other Databases showing ALDH2

Specialized Databases showing ALDH2

Licensable Technologiesfor ALDH2

Servicesfor ALDH2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ALDH2

Summaries
for ALDH2

Genomic Location
for ALDH2

Proteins
for ALDH2

Protein Domains/
Families
for ALDH2

Gene Function
for ALDH2

Pathways & Interactions
for ALDH2

Drugs & Compounds
for ALDH2

Transcripts
for ALDH2

Expression
for ALDH2

Orthologs
for ALDH2

Paralogs
for ALDH2

SNPs/Variants
for ALDH2

Disorders & Mutations
for ALDH2

Medical News
for ALDH2

Publications
for ALDH2

Licensable Technologies
for ALDH2

Services
for ALDH2