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ALDH1L2 Gene

protein-coding   GIFtS: 56
GCID: GC12M105417

Aldehyde Dehydrogenase 1 Family, Member L2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Aldehyde Dehydrogenase 1 Family, Member L21 2     10-Formyltetrahydrofolate Dehydrogenase ALDH1L22
Mitochondrial 10-Formyltetrahydrofolate Dehydrogenase1 2     Aldehyde Dehydrogenase Family 1 Member L2, Mitochondrial2
Mitochondrial 10-FTHFDH2 3     Probable 10-Formyltetrahydrofolate Dehydrogenase ALDH1L22
mtFDH2 3     Aldehyde Dehydrogenase Family 1 Member L23
EC 1.5.1.63 8     

External Ids:    HGNC: 267771   Entrez Gene: 1604282   Ensembl: ENSG000001360107   OMIM: 6135845   UniProtKB: Q3SY693   

Export aliases for ALDH1L2 gene to outside databases

Previous GC identifers: GC12M103921 GC12M102472


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ALDH1L2 Gene:
This gene encodes a member of both the aldehyde dehydrogenase superfamily and the formyl transferase superfamily.
This member is the mitochondrial form of 10-formyltetrahydrofolate dehydrogenase (FDH), which converts
10-formyltetrahydrofolate to tetrahydrofolate and CO2 in an NADP(+)-dependent reaction, and plays an essential
role in the distribution of one-carbon groups between the cytosolic and mitochondrial compartments of the cell.
Alternatively spliced transcript variants have been found for this gene.(provided by RefSeq, Oct 2010)

GeneCards Summary for ALDH1L2 Gene:
ALDH1L2 (aldehyde dehydrogenase 1 family, member L2) is a protein-coding gene. Diseases associated with ALDH1L2 include bronchiolitis, and tuberculosis. GO annotations related to this gene include formyltetrahydrofolate dehydrogenase activity and methyltransferase activity. An important paralog of this gene is ALDH1A1.

Gene Wiki entry for ALDH1L2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the ALDH1L2 gene promoter:
         Bach1   AhR   Sp1   Ik-2   CUTL1   Arnt   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidALDH1L2 promoter sequence
   Search Chromatin IP Primers for ALDH1L2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ALDH1L2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q23.3   Ensembl cytogenetic band:  12q23.3   HGNC cytogenetic band: 12q23.3

ALDH1L2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ALDH1L2 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M105417:  view genomic region     (about GC identifiers)

Start:
105,413,562 bp from pter      End:
105,478,355 bp from pter
Size:
64,794 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: AL1L2_HUMAN, Q3SY69 (See protein sequence)
Recommended Name: Mitochondrial 10-formyltetrahydrofolate dehydrogenase  
Size: 923 amino acids; 101746 Da
Sequence caution: Sequence=AAI03936.1; Type=Erroneous translation; Note=Wrong choice of CDS;
Secondary accessions: Q3SY68 Q68D62 Q6AI55 Q8N922
Alternative splicing: 3 isoforms:  Q3SY69-1   Q3SY69-2   Q3SY69-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ALDH1L2: NX_Q3SY69

Explore proteomics data for ALDH1L2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for ALDH1L2 (Q3SY69) (see all 14)
     TINPTDG  NEDVYMA  EDSTDFFK  YNRFLFPEG 


    See ALDH1L2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001029345.2  
    ENSEMBL proteins: 
     ENSP00000258494   ENSP00000447538   ENSP00000447464   ENSP00000389608  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ALDH: Aldehyde dehydrogenases

    Selected InterPro protein domains (see all 12):
     IPR005793 Formyl_trans_C
     IPR016163 Ald_DH_C
     IPR011034 Formyl_transferase_C-like
     IPR002376 Formyl_transf_N
     IPR001555 GART_AS

    Graphical View of Domain Structure for InterPro Entry Q3SY69

    ProtoNet protein and cluster: Q3SY69

    1 Blocks protein domain: IPB005793 Formyl transferase

    UniProtKB/Swiss-Prot: AL1L2_HUMAN, Q3SY69
    Similarity: In the N-terminal section; belongs to the GART family
    Similarity: In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily
    Similarity: Contains 1 acyl carrier domain


    ALDH1L2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AL1L2_HUMAN, Q3SY69
    Catalytic activity: 10-formyltetrahydrofolate + NADP(+) + H(2)O = tetrahydrofolate + CO(2) + NADPH

         Enzyme Number (IUBMB): EC 1.5.1.61 2

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0008168methyltransferase activity IEA--
    GO:0016155formyltetrahydrofolate dehydrogenase activity IEA--
    GO:0016491oxidoreductase activity ----
    GO:0016620oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEA--
         
    ALDH1L2 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for ALDH1L2:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e 

    Animal Models:
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    hsa-miR-194* hsa-miR-361-5p hsa-miR-607 hsa-miR-376b hsa-miR-128 hsa-miR-3921 hsa-miR-3171 hsa-miR-10b*
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    AL1L2_HUMAN, Q3SY69: Mitochondrion
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005739mitochondrion IDA--

    ALDH1L2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ALDH1L2 About    
    See pathways by source

    SuperPathContained pathways About
    1One carbon pool by folate
    One carbon pool by folate0.53

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1 Kegg Pathway  (Kegg details for ALDH1L2):
        One carbon pool by folate


    ALDH1L2 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ALDH1L2
    Interactions:

        Search GeneGlobe Interaction Network for ALDH1L2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    Selected Interacting proteins for ALDH1L2 (Q3SY692, 3 ENSP000002584944) via UniProtKB, MINT, STRING, and/or I2D (see all 260)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ICT1Q141972, 3, ENSP000003015854MINT-8079030 I2D: score=1 STRING: ENSP00000301585
    SHMT2P348972, ENSP000003336674MINT-8079030 STRING: ENSP00000333667
    ATG101Q9BSB43I2D: score=1 
    CAMKK2Q96RR43I2D: score=1 
    WIPI2Q9Y4P83I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006730one-carbon metabolic process IEA--
    GO:0008152metabolic process ----
    GO:0009058biosynthetic process IEA--
    GO:000925810-formyltetrahydrofolate catabolic process IEA--
    GO:0055114oxidation-reduction process ----

    ALDH1L2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for ALDH1L2 (AL1L2)

    3 HMDB Compounds for ALDH1L2    About this table
    CompoundSynonyms CAS #PubMed Ids
    NADPAdenine-nicotinamide dinucleotide phosphate (see all 18)53-59-8--
    NADPH2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23)53-57-6--
    Pantetheine 4'-phosphate4'-Phosphopantetheine (see all 8)2226-71-3--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ALDH1L2 gene: 
    NM_001034173.3  

    Unigene Cluster for ALDH1L2:

    Aldehyde dehydrogenase 1 family, member L2
    Hs.42572  [show with all ESTs]
    Unigene Representative Sequence: NM_001034173
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000549335(uc009zuo.3) ENST00000258494(uc009zup.3 uc001tlc.3)
    ENST00000552270 ENST00000548418 ENST00000552427 ENST00000424857
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    hsa-miR-194* hsa-miR-361-5p hsa-miR-607 hsa-miR-376b hsa-miR-128 hsa-miR-3921 hsa-miR-3171 hsa-miR-10b*
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    Additional mRNA sequence: 

    AF086109.1 AK094088.1 AK095827.1 AK300373.1 BC103934.1 BX537599.1 CR749561.1 NR_027752.1 

    4 DOTS entries:

    DT.308648  DT.95196886  DT.121210699  DT.121210712 

    2 AceView cDNA sequences:

    BX497818 CN483502 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for ALDH1L2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b
    SP1:                                                                                                                              
    SP2:                                                                                                                    -         


    ECgene alternative splicing isoforms for ALDH1L2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ALDH1L2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ALDH1L2 Expression
    About this image


    ALDH1L2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 4 entries
             Line H9 (Naive)
     
     Lung (Respiratory System)
             Basal Cells Respiratory Bronchioles
     
     Fibroblasts
             Detroit 551
     
     Epidermis (Integumentary System)
             Detroit 551
    ALDH1L2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ALDH1L2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.42572

    UniProtKB/Swiss-Prot: AL1L2_HUMAN, Q3SY69
    Tissue specificity: Highly expressed in pancreas, heart, brain and skeletal muscle

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ALDH1L2 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Aldh1l21 , 5 aldehyde dehydrogenase 1 family, member L21, 5 86.13(n)1
    92.31(a)1
      10 (41.27 cM)5
    2161881  NM_153543.21  NP_705771.21 
     834874505 
    chicken
    (Gallus gallus)
    Aves LOC1008573601 mitochondrial 10-formyltetrahydrofolate dehydrogenase-like 78.05(n)
    83.84(a)
      100857360  XM_003640425.2  XP_003640473.1 
    lizard
    (Anolis carolinensis)
    Reptilia ALDH1L26
    aldehyde dehydrogenase 1 family, member L2
    84(a)
    1 ↔ 1
    5(18708372-18740392)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.26042 Transcribed sequence with moderate similarity to protein more 75.13(n)    142001957 
    zebrafish
    (Danio rerio)
    Actinopterygii aldh1l21 aldehyde dehydrogenase 1 family, member L2 72.81(n)
    80.61(a)
      100333269  XM_002661372.3  XP_002661418.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG86651 CG8665 58.71(n)
    59.2(a)
      35407  NM_136263.2  NP_610107.1 
    worm
    (Caenorhabditis elegans)
    Secernentea alh-36
    Protein ALH-3 (alh-3) mRNA, complete cds
    59(a)
    1 → many
    IV(11022603-11025872) WBGene00000109
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ALD56
    ALD46
    (see all 3)
    Mitochondrial aldehyde dehydrogenase, involved in ...
    Mitochondrial aldehyde dehydrogenase, required for...
    (see all 3)
    44(a)
    42(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    V(304030-305592) YER073W
    XV(1039840-1041399) YOR374W


    ENSEMBL Gene Tree for ALDH1L2 (if available)
    TreeFam Gene Tree for ALDH1L2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ALDH1L2 gene
    ALDH1A12  ENSG000002577672  ALDH1A22  ALDH1B12  ALDH7A12  ALDH6A12  ALDH22  ALDH8A12  
    ALDH9A12  ALDH1A32  ALDH1L12  
    11 SIMAP similar genes for ALDH1L2 using alignment to 2 protein entries:     AL1L2_HUMAN (see all proteins):
    ALDH1L1    ALDH1A1    ALDH1A2    ALDH1B1    ALDH2    ALDH1A3
    ALDH5A1    ALDH7A1    ALDH9A1    ALDH6A1    ALDH8A1

    ALDH1L2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ALDH1L2
    PGOHUM00000239380


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ALDH1L2 (see all 1670)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs757596831,2
    C--102496011(+) ATGAA-/GMMAAT 2 -- int10--------
    rs2013556581,2
    C--102499598(+) CTCTC-/TCTCTCTCTCTCT
    CTCTCTATATATATA
    TATAT
    2 -- int10--------
    rs108613201,2
    A--102499640(+) tatatA/TtTttt 2 -- int10--------
    rs116110371,2
    A,H--102499642(+) tatatA/Tttttt 2 -- int1 trp30--------
    rs111123391,2
    C,A--102499669(+) TTTTTC/TTGTGA 2 -- int1 trp31Minor allele frequency- T:0.50CSA 2
    rs1824988701,2
    C--102499695(+) TTGTTC/GCCCAG 2 -- int10--------
    rs108613211,2
    C,F,A--102499716(+) AGTGGC/TACGAT 2 -- int15Minor allele frequency- T:0.35NA WA CSA 130
    rs108613221,2
    C,F,A--102499719(+) GGCACG/AATCTC 2 -- int15Minor allele frequency- A:0.35NA WA CSA 130
    rs354277641,2
    C--102514259(+) AAAAA-/A/A   
      A
    /AAAA
    GATGA
    2 -- int11NA 2
    rs2011434441,2
    C--102524796(+) AGGGG-/CTTTGG 2 -- int10--------

    HapMap Linkage Disequilibrium report for ALDH1L2 (105413562 - 105478355 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for ALDH1L2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1010041CNV Deletion20482838
    esv274115CNV Insertion20981092
    esv270837CNV Insertion20981092
    esv1002429CNV Insertion20482838
    nsv899498CNV Gain21882294
    nsv832506CNV Gain17160897
    nsv832505CNV Gain17160897
    nsv899495CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613584    OMIM disorders: --

    3 diseases for ALDH1L2:    
    About MalaCards
    bronchiolitis    tuberculosis    malaria


    ALDH1L2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ALDH1L2
    Human Genome Epidemiology (HuGE) Navigator: ALDH1L2 (2 documents)

    Export disorders for ALDH1L2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ALDH1L2 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with ALDH1L2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. ALDH1L2 is the mitochondrial homolog of 10-formyltetrahydrofolate dehydrogenase. (PubMed id 20498374)1, 2, 3 Krupenko N.I.... Krupenko S.A. (J. Biol. Chem. 2010)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. (PubMed id 23382691)1 Lauc G....Rudan I. (PLoS Genet. 2013)
    6. Identification and analysis of intermediate size noncoding RNAs in the human fetal brain. (PubMed id 21789175)1 Yan D....Chen R. (PLoS ONE 2011)
    7. Enzymatic properties of ALDH1L2, a mitochondrial 10-formyltetrahydrofolate dehydrogenase. (PubMed id 21238436)1 Strickland K.C....Krupenko S.A. (Chem. Biol. Interact. 2011)
    8. A whole genome screen for HIV restriction factors. (PubMed id 22082156)1 Liu L....McKnight A. (Retrovirology 2011)
    9. Acyl carrier protein-specific 4'-phosphopantetheinyl transferase activates 10-formyltetrahydrofolate dehydrogenase. (PubMed id 19933275)1 Strickland K.C....Krupenko S.A. (J. Biol. Chem. 2010)
    10. A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome. (PubMed id 20186120)1 Richter R....Chrzanowska-Lightowlers Z.M. (EMBO J. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 160428 HGNC: 26777 AceView: FLJ38508.1 Ensembl:ENSG00000136010 euGenes: HUgn160428
    ECgene: ALDH1L2 Kegg: 160428 H-InvDB: ALDH1L2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ALDH1L2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for ALDH1L2 gene:
    Search GeneIP for patents involving ALDH1L2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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