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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ALDH1L2 Gene

protein-coding GIFtS: 55
GCID: GC12M105417

aldehyde dehydrogenase 1 family, member L2

Explore 3 diseases affiliated with
ALDH1L2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Aldehyde Dehydrogenase 1 Family, Member L2¹ ²		10-Formyltetrahydrofolate Dehydrogenase ALDH1L2²
MtFDH¹		Aldehyde Dehydrogenase Family 1 Member L2, Mitochondrial²
Mitochondrial 10-FTHFDH² ³		Mitochondrial 10-Formyltetrahydrofolate Dehydrogenase²
EC 1.5.1.6³ ⁸		Probable 10-Formyltetrahydrofolate Dehydrogenase ALDH1L2²
FLJ38508¹		Aldehyde Dehydrogenase Family 1 Member L2³

External Ids:	HGNC: 26777¹	Entrez Gene: 160428²	Ensembl: ENSG00000136010⁷	OMIM: 613584⁵	UniProtKB: Q3SY69³

ORGUL members:
	NONCODE:n407999

Export aliases for ALDH1L2 gene to outside databases

Previous GC identifers: GC12M103921 GC12M102472

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ALDH1L2:

This gene encodes a member of both the aldehyde dehydrogenase superfamily and the formyl transferase superfamily. This

member is the mitochondrial form of 10-formyltetrahydrofolate dehydrogenase (FDH), which converts

10-formyltetrahydrofolate to tetrahydrofolate and CO2 in an NADP(+)-dependent reaction, and plays an essential role in

the distribution of one-carbon groups between the cytosolic and mitochondrial compartments of the cell. Alternatively

spliced transcript variants have been found for this gene.(provided by RefSeq, Oct 2010)

Gene Wiki entry for ALDH1L2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_029419.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ALDH1L2 gene promoter:
Bach1 AhR Sp1 Ik-2 CUTL1 Arnt
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ALDH1L2 promoter sequence

Search SABiosciences Chromatin IP Primers for ALDH1L2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ALDH1L2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q23.3 Ensembl cytogenetic band: 12q23.3 HGNC cytogenetic band: 12q23.3

ALDH1L2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ALDH1L2 gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12M105417: view genomic region (about GC identifiers)

Start:	105,413,562 bp from pter	End:	105,478,355 bp from pter
Size:	64,794 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: AL1L2_HUMAN, Q3SY69 (See protein sequence)

Recommended Name: Mitochondrial 10-formyltetrahydrofolate dehydrogenase

Size: 923 amino acids; 101746 Da

Subcellular location: Mitochondrion

Sequence caution: Sequence=AAI03936.1; Type=Erroneous translation; Note=Wrong choice of CDS;

Secondary accessions: Q3SY68 Q68D62 Q6AI55 Q8N922

Alternative splicing: 3 isoforms: Q3SY69-1 Q3SY69-2 Q3SY69-3 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ALDH1L2: NX_Q3SY69

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q3SY69

4/14 DME Specific Peptides for ALDH1L2 (Q3SY69) (see all 14)

TINPTDG

NEDVYMA

EDSTDFFK

YNRFLFPEG

ALDH1L2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001029345.2

ENSEMBL proteins:

ENSP00000258494 ENSP00000447538 ENSP00000447464 ENSP00000389608

Human Recombinant Protein Products for ALDH1L2:

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	Uscn Proteins for ALDH1L2

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005739	mitochondrion	IDA	--

ALDH1L2 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ALDH1L2 for domains About GeneDecksing

5/12 InterPro domains/families (see all 12):

IPR001555 GART_AS

IPR005793 Formyl_trans_C

IPR016162 Ald_DH_N

IPR006162 PPantetheine_attach_site

IPR016163 Ald_DH_C

Graphical View of Domain Structure for InterPro Entry Q3SY69

ProtoNet protein and cluster: Q3SY69

1 Blocks protein family: IPB005793 Formyl transferase

UniProtKB/Swiss-Prot: AL1L2_HUMAN, Q3SY69

Similarity: In the N-terminal section; belongs to the GART family

Similarity: In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily

Similarity: Contains 1 acyl carrier domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: AL1L2_HUMAN, Q3SY69

Catalytic activity: 10-formyltetrahydrofolate + NADP(+) + H(2)O = tetrahydrofolate + CO(2) + NADPH

Enzyme Number (IUBMB): EC 1.5.1.6¹ ²

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008168	methyltransferase activity	IEA	--
GO:0016155	formyltetrahydrofolate dehydrogenase activity	IEA	--
GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	IEA	--
GO:0016742	hydroxymethyl-, formyl- and related transferase activity	IEA	--
GO:0031177	phosphopantetheine binding	--	--

ALDH1L2 for ontologies About GeneDecksing

Phenotypes:
3 GenomeRNAi human phenotypes for ALDH1L2:

Decreased NANOG protein expres

Decreased OCT4 protein express

Decreased POU5F1-GFP protein e

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for ALDH1L2

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALDH1L2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

One Carbon Metabolism

One carbon pool by folate

0.52

Pathway sources
See GeneCards unified pathways
Show all pathways

1 Kegg Pathway (Kegg details for ALDH1L2):

One carbon pool by folate

ALDH1L2 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ALDH1L2

STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

5/242 Interacting proteins for ALDH1L2 (Q3SY69^{2, 3} ENSP00000258494⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 242)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ICT1	Q14197²^,³, ENSP00000301585⁴	MINT-8079030 I2D: score=1 STRING: ENSP00000301585
SHMT2	P34897², ENSP00000333667⁴	MINT-8079030 STRING: ENSP00000333667
C12orf44	Q9BSB4³	I2D: score=1
CAMKK2	Q96RR4³	I2D: score=1
WIPI2	Q9Y4P8³	I2D: score=1

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006730	one-carbon metabolic process	IEA	--
GO:0009058	biosynthetic process	IEA	--
GO:0009258	10-formyltetrahydrofolate catabolic process	IEA	--

ALDH1L2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ALDH1L2

3 HMDB Compounds for ALDH1L2 About this table

Compound	Synonyms	CAS #	PubMed Ids
NADP	Adenine-nicotinamide dinucleotide phosphate (see all 18)	53-59-8	--
NADPH	2'-(dihydrogen phosphate) 5'-(trihydrogen pyrophosphate) Adenosine 5'-ester with 1,4-dihydro-1-b-D-ribofuranosylnicotinamide (see all 23)	53-57-6	--
Pantetheine 4'-phosphate	4'-Phosphopantetheine (see all 8)	2226-71-3	--

Search CenterWatch for drugs/clinical trials and news about ALDH1L2 / AL1L2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ALDH1L2 gene:

NM_001034173.3

Unigene Cluster for ALDH1L2:

Aldehyde dehydrogenase 1 family, member L2

Hs.42572 [show with all ESTs]

Unigene Representative Sequence: NM_001034173

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000549335(uc009zuo.3) ENST00000258494(uc009zup.3 uc001tlc.3)

ENST00000552270 ENST00000548418 ENST00000552427 ENST00000424857

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		hsa-miR-194* hsa-miR-361-5p hsa-miR-607 hsa-miR-376b hsa-miR-128 hsa-miR-3921 hsa-miR-3171 hsa-miR-10b*

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Additional cDNA sequence:

AF086109.1 AK094088.1 AK095827.1 AK300373.1 BC103934.1 BX537599.1 CR749561.1 NR_027752.1

4 DOTS entries:

DT.308648 DT.95196886 DT.121210699 DT.121210712

2 AceView cDNA sequences:

BX497818 CN483502

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for ALDH1L2 About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19	^	20a	·	20b
SP1:
SP2:																																							-

ECgene alternative splicing isoforms for ALDH1L2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ALDH1L2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

ALDH1L2 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Lung

Respiratory Bronchioles

Basal Cells

Lung

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 3 LifeMap Cells

Name

Category

PureStem™ mesenchymal Progenitor SK11 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

PureStem™ mesenchymal progenitor 7SMOO32 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

Line H9 (WA09) (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

See ALDH1L2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ALDH1L2

SOURCE GeneReport for Unigene cluster: Hs.42572

UniProtKB/Swiss-Prot: AL1L2_HUMAN, Q3SY69

Tissue specificity: Highly expressed in pancreas, heart, brain and skeletal muscle

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the last universal common ancestor (LUCA).

Orthologs for ALDH1L2 gene from 9/28 species (see all 28) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	LOC100857360¹	mitochondrial 10-formyltetrahydrofolate dehydrogenase-like	78.09(n) 83.84(a)		100857360 XM_003640425.1 XP_003640473.1
lizard (Anolis carolinensis)	Reptilia	ALDH1L2⁶	--	84(a)	1 ↔ 1	5(18710017-18740392)
tropical clawed frog (Xenopus tropicalis)	Amphibia	Str.2604²	Transcribed sequence with moderate similarity to protein more	75.13(n)		142001957
zebrafish (Danio rerio)	Actinopterygii	aldh1l2¹	aldehyde dehydrogenase 1 family, member L2	72.81(n) 80.61(a)		100333269 XM_002661372.2 XP_002661418.2
fruit fly (Drosophila melanogaster)	Insecta	CG8665¹	CG8665	58.75(n) 59.2(a)		35407 NM_136263.1 NP_610107.1
worm (Caenorhabditis elegans)	Secernentea	alh-3⁶	ALdehyde deHydrogenase family member (alh-3)	59(a)	1 → many	IV(11022580-11025851)
thale cress (Arabidopsis thaliana)	eudicotyledons	ALDH10A9⁶ ALDH10A8⁶	betaine aldehyde dehydrogenase 1	36(a) 36(a)	possible ortholog possible ortholog	3(17786140-17790008) 1(28139009-28142744)
rice (Oryza sativa)	Liliopsida	-- SK2⁶	aldehyde dehydrogenase, putative, expressed	36(a) 35(a)	possible ortholog possible ortholog	4(22986281-22991224) 8(20377081-20383348)
E. coli (Escherichia coli)	Gamma proteobacteria	aldB⁶	aldehyde dehydrogenase B	34(a)	possible ortholog	Chromosome(3752996-3754534)

ENSEMBL Gene Tree for ALDH1L2 (if available)
TreeFam Gene Tree for ALDH1L2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ALDH1L2 gene

ALDH1A1² ALDH1A2² ENSG00000257767² ALDH1B1² ALDH7A1² ALDH2² ALDH16A1² ALDH8A1²

ALDH9A1² ALDH1A3² ALDH1L1²

11 SIMAP similar genes for ALDH1L2 using alignment to 2 protein entries: AL1L2_HUMAN (see all proteins):

ALDH1L1 ALDH1A2 ALDH1A1 ALDH1B1 ALDH2 ALDH1A3

ALDH5A1 ALDH7A1 ALDH9A1 ALDH6A1 ALDH8A1

ALDH1L2 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for ALDH1L2
PGOHUM00000239380

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs76570019^1,2		--	102472585(+)	`TTTTGT/AGACAT`	2	--	ds500¹		2		CSA WA	119
rs79397244^1,2		--	102472802(+)	`AGATAC/TCATCT`	2	--	ut3¹ nc-transcript-variant		0	--	--	--	--
rs1129559^1,2	C,F,H	--	102473123(-)	`NNNNTG/AGAAAT`	2	--	ut3¹ nc-transcript-variant		7		MN NS EA NA	598
rs7316290^1,2	C,F,H	--	102473170(+)	`TTAGTT/CTAACC`	2	--	ut3¹ nc-transcript-variant		6		NS EA CSA WA	536
rs11835812^1,2	C,F,H	--	102473424(+)	`acattC/Ataatg`	2	--	ut3¹ nc-transcript-variant		5		NS EA NA	406
rs76040926^1,2		--	102473560(+)	`AAGCAG/TAGTCA`	2	--	ut3¹ nc-transcript-variant		0	--	--	--	--
rs76560134^1,2	F	--	102473587(+)	`TCAGAT/CGATAT`	2	--	ut3¹ nc-transcript-variant		1		WA	118
rs1801070^1,2	C	--	102473768(-)	`CTCTCA/TTCAAG`	2	--	ut3¹ nc-transcript-variant		3		NA WA	240
rs16891^1,2	C,F,H	--	102473884(-)	`CTGTCC/ATTATT`	2	--	ut3¹ nc-transcript-variant		9		NS EA NA WA	782
rs11112312^1,2		--	102474416(+)	`CACTGC/TACTGC`	2	--	ut3¹ nc-transcript-variant		0	--	--	--	--

HapMap Linkage Disequilibrium report for ALDH1L2 (105413562 - 105478355 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ALDH1L2: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ALDH1L2 for disorders           About GeneDecksing

OMIM gene information: 613584    OMIM disorders: --

3 diseases for ALDH1L2:    About MalaCards

retinitis tuberculosis mycobacterium tuberculosis

Human Genome Epidemiology (HuGE) Navigator: ALDH1L2 (2 documents)

Export disorders for ALDH1L2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ALDH1L2 gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with ALDH1L2)

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ALDH1L2 is the mitochondrial homolog of 10-formyltetr ahydrofolate dehydrogenase. (PubMed id 20498374)^{1, 2, 3} Krupenko N.I....Krupenko S.A. (2010)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Identification and analysis of intermediate size nonc oding RNAs in the human fetal brain. (PubMed id 21789175)¹ Yan D....Chen R. (2011)
Enzymatic properties of ALDH1L2, a mitochondrial 10-f ormyltetrahydrofolate dehydrogenase. (PubMed id 21238436)¹ Strickland K.C....Krupenko S.A. (2011)
Acyl carrier protein-specific 4'-phosphopantetheinyl transferase activates 10-formyltetrahydrofolate dehydrogenase. (PubMed id 19933275)¹ Strickland K.C....Krupenko S.A. (2010)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome. (PubMed id 20186120)¹ Richter R....Chrzanowska-Lightowlers Z.M. (2010)
Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)¹ Hendrickson S.L....O'Brien S.J. (2010)
Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)² Choudhary C.... Mann M. (2009)
Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)¹ Barbe L....Andersson-Svahn H. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 160428	HGNC: 26777	AceView: FLJ38508.1	Ensembl:ENSG00000136010	euGenes: HUgn160428
ECgene: ALDH1L2	Kegg: 160428	H-InvDB: ALDH1L2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ALDH1L2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ALDH1L2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for ALDH1L2 gene:
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ALDH1L2 Gene

aldehyde dehydrogenase 1 family, member L2

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ALDH1L2 Gene

aldehyde dehydrogenase 1 family, member L2

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