Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ALDH1B1 Gene

protein-coding   GIFtS: 67
GCID: GC09P038392

aldehyde dehydrogenase 1 family, member B1


(Previous symbol: ALDH5)
 Explore 5 diseases affiliated with
ALDH1B1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ALDH1B1    

Aliases
for ALDH1B1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Aldehyde Dehydrogenase 1 Family, Member B11 2     Acetaldehyde Dehydrogenase 52
ALDH51 2 3 5     Aldehyde Dehydrogenase X, Mitochondrial2
ALDHX1 2 3     ALDH Class 22
Aldehyde Dehydrogenase 52 3     Aldehyde Dehydrogenase Family 1 Member B13
EC 1.2.1.33 8     EC 1.2.18

External Ids:    HGNC: 4071   Entrez Gene: 2192   Ensembl: ENSG000001371247   OMIM: 1006705   UniProtKB: P308373   

Export aliases for ALDH1B1 gene to outside databases

Previous GC identifers: GC09P038704 GC09P038562 GC09P038382 GC09P038345


Summaries
for ALDH1B1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ALDH1B1:
This protein belongs to the aldehyde dehydrogenases family of proteins. Aldehyde dehydrogenase is the second enzyme of
the major oxidative pathway of alcohol metabolism. This gene does not contain introns in the coding sequence. The
variation of this locus may affect the development of alcohol-related problems. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: AL1B1_HUMAN, P30837
Function: ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the
metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation

Gene Wiki entry for ALDH1B1


Genomic Views
for ALDH1B1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.1  NT_008413.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ALDH1B1 gene promoter:
         USF1   USF2   USF-1:USF-2   NF-AT   NF-AT4   E2F-1   NF-AT2   USF-1   NF-AT3   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ALDH1B1 promoter sequence
   Search SABiosciences Chromatin IP Primers for ALDH1B1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ALDH1B1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p11.1   Ensembl cytogenetic band:  9p13.2   HGNC cytogenetic band: 9p13

ALDH1B1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ALDH1B1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P038392:  view genomic region     (about GC identifiers)

Start:
 38,392,661 bp from pter      End:
 38,398,658 bp from pter
Size:
 5,998 bases      Orientation:
 plus strand

Proteins
for ALDH1B1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: AL1B1_HUMAN, P30837 (See protein sequence)
Recommended Name: Aldehyde dehydrogenase X, mitochondrial precursor  
Size: 517 amino acids; 57206 Da
Subunit: Homotetramer (By similarity)
Subcellular location: Mitochondrion matrix
Secondary accessions: B2R8F0 Q8WX76 Q9BV45

Explore the universe of human proteins at neXtProt for ALDH1B1: NX_P30837

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P30837

    • 4/30 DME Specific Peptides for ALDH1B1 (P30837) (see all 30)
     TLELGGK  AGSRTFV  FVEESIY  VTLELGG 

    ALDH1B1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_000683.3  
    ENSEMBL proteins: 
     ENSP00000366927  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: ALDH1B1
    OriGene Protein Over-expression Lysate: ALDH1B1
    OriGene Custom Protein Services for ALDH1B1 
    GenScript Custom Purified and Recombinant Proteins Services for ALDH1B1
    Novus Biologicals ALDH1B1 Protein
    Novus Biologicals ALDH1B1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ALDH1B1

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005739mitochondrion IDA--
    GO:0005759mitochondrial matrix IEA--
    GO:0043231intracellular membrane-bounded organelle IDA--


    ALDH1B1 for ontologies           About GeneDecksing



    ALDH1B1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for ALDH1B1 
    GenScript Custom Superior Antibodies Services for ALDH1B1
    Novus Biologicals ALDH1B1 Antibodies
    Abcam antibodies for ALDH1B1 
    Uscn Antibodies for ALDH1B1
    ThermoFisher Antibodies for ALDH1B1

    Assay Products for ALDH1B1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ALDH1B1
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for ALDH1B1

    Protein Domains /
    Families
    for ALDH1B1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ALDH1B1 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR016162 Ald_DH_N
     IPR016163 Ald_DH_C
     IPR016161 Ald_DH/histidinol_DH
     IPR015590 Aldehyde_DH_dom
     IPR016160 Ald_DH_CS

    Graphical View of Domain Structure for InterPro Entry P30837

    ProtoNet protein and cluster: P30837

    1 Blocks protein family: IPB002086 Aldehyde dehydrogenase

    UniProtKB/Swiss-Prot: AL1B1_HUMAN, P30837
    Similarity: Belongs to the aldehyde dehydrogenase family


    Function
    for ALDH1B1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: AL1B1_HUMAN, P30837
    Function: ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the
    metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation
    Catalytic activity: An aldehyde + NAD(+) + H(2)O = a carboxylate + NADH

    Enzyme Numbers (IUBMB): EC 1.2.1.31 2 EC 1.2.12

    miRNA
    Products:            		 OriGene 3'-UTR Clone: ALDH1B1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ALDH1B1
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate ALDH1B1:
    hsa-miR-221* hsa-miR-548p hsa-miR-876-3p
    SwitchGear 3'UTR luciferase reporter plasmid: ALDH1B1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ALDH1B1 (see all 7)
    OriGene shRNA RFP: ALDH1B1
    OriGene siRNA: ALDH1B1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ALDH1B1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ALDH1B1

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ALDH1B1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ALDH1B1
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: ALDH1B1 (NM_000692)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ALDH1B1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALDH1B1 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for ALDH1B1
    Search LifeMap BioReagents cell lines for ALDH1B1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALDH1B1

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004029aldehyde dehydrogenase (NAD) activity IEA--
    GO:0016620oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor ----


    ALDH1B1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for ALDH1B1:
     Upregulation of Wnt/beta-caten 


    Pathways & Interactions
    for ALDH1B1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/14 super-pathways (see all 14) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Pentose and glucuronate interconversions
    		Pentose and glucuronate interconversions1.00
    		Ascorbate and aldarate metabolism0.62
    2Tyrosine metabolism
    		Tyrosine metabolism p.1 (dopamine) 0.28
    		Tyrosine metabolism p.1 (dopamine)0.28
    3Branched-chain amino acid catabolism
    		Valine, leucine and isoleucine degradation0.39
    		Propanoate metabolism0.07
    4Pyruvate metabolism
    		Pyruvate metabolism1.00
    5Glycerolipid metabolism
    		Glycerolipid metabolism1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for ALDH1B1
        Tyrosine metabolism p.1 (dopamine)


    1 GeneGo (Thomson Reuters) Pathway for ALDH1B1
        Tyrosine metabolism p.1 (dopamine)

    1 BioSystems Pathway for ALDH1B1 
        putrescine degradation III


    5/14         Kegg Pathways  (Kegg details for ALDH1B1) (see all 14):
        Glycolysis / Gluconeogenesis
    Pentose and glucuronate interconversions
    Ascorbate and aldarate metabolism
    Fatty acid metabolism
    Valine, leucine and isoleucine degradation

    UniProtKB/Swiss-Prot: AL1B1_HUMAN, P30837
    Pathway: Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2


    ALDH1B1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ALDH1B1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/314 Interacting proteins for ALDH1B1 (P308372, 3 ENSP000003669274) via UniProtKB, MINT, STRING, and/or I2D (see all 314)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYCP011063, ENSP000003672074I2D: score=3 STRING: ENSP00000367207
    ENSG00000258947Q135093I2D: score=1 
    TUBB3Q135093I2D: score=1 
    CADP277083, ENSP000002647054I2D: score=1 STRING: ENSP00000264705
    ICT1Q141972, ENSP000003015854MINT-8079030 STRING: ENSP00000301585
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process NAS1306115
    GO:0006068ethanol catabolic process IEA--


    ALDH1B1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ALDH1B1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ALDH1B1

    10/41 HMDB Compounds for ALDH1B1 (see all 41)    About this table
    CompoundSynonyms CAS #PubMed Ids
    (S)-Methylmalonic acid semialdehyde(S)-Methylmalonate semialdehyde (see all 3)99043-16-0--
    1-Butanol1-Butanol (see all 10)71-36-3--
    1-Hexanol1-Hexyl alcohol (see all 30)111-27-3--
    1-Pentanol1-Pentol (see all 34)71-41-0--
    2-Propyn-1-al ----
    20-Oxo-leukotriene E420-oxo-LTE(,4) (see all 3)----
    20-oxo-leukotriene B420-carboxyleukotriene B4 ----
    3-Butyn-1-al 52844-23-2--
    3a,7a-Dihydroxy-5b-cholestan-26-al3a,7a-Dihydroxy-5b-cholestan-26-al;3alpha,7alpha-dihydroxy-5beta-cholestan-27-al;5beta-cholestane-3alpha,7alpha-diol-27-al;5beta-cholestan-27-al-3alpha,7alpha-diol ----
    4-Acetamidobutanoic acidN-Acetyl-4-aminobutanoate (see all 11)3025-96-5--

    1 DrugBank Compound for ALDH1B1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    NADHbeta-DPNH (see all 18)606-68-8target--17139284 17016423

    Search CenterWatch for drugs/clinical trials and news about ALDH1B1 / AL1B1 

    Transcripts
    for ALDH1B1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ALDH1B1 gene: 
    NM_000692.4  

    Unigene Clusters for ALDH1B1:

    Aldehyde dehydrogenase 1 family, member B1
    Hs.436219  [show with all ESTs], Hs.743532  [show with all ESTs]
    Unigene Representative Sequences: NM_000692, BT007418
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000377698(uc004aay.3)

    miRNA
    Products:             		 OriGene 3'-UTR Clone: ALDH1B1
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ALDH1B1
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate ALDH1B1:
    hsa-miR-221* hsa-miR-548p hsa-miR-876-3p
    SwitchGear 3'UTR luciferase reporter plasmid: ALDH1B1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ALDH1B1 (see all 7)
    OriGene shRNA RFP: ALDH1B1
    OriGene siRNA: ALDH1B1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ALDH1B1
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ALDH1B1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ALDH1B1
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: ALDH1B1 (NM_000692)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ALDH1B1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALDH1B1 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ALDH1B1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ALDH1B1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ALDH1B1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ALDH1B1

    Additional cDNA sequence: 

    BC127734.1 BT007418.1 

    4 DOTS entries:

    DT.443359  DT.97848183  DT.75103462  DT.121167274 

    24/149 AceView cDNA sequences (see all 149):

    AA305312 AL135209 AI520967 BI850371 BM917091 BU194396 BU074303 NM_000692 
    CA429736 AI476617 BQ072352 AA313769 AA702358 BM558810 BG325887 BQ953419 
    BX419182 BM835087 BM972125 BQ921383 AA314712 BG334863 BM749166 AA918488 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for ALDH1B1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b
    SP1:                              
    SP2:              -               


    ECgene alternative splicing isoforms for ALDH1B1

    Expression
    for ALDH1B1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ALDH1B1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AATTAACTCC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ALDH1B1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LiverLiver LobulePeriportal HepatocytesLiver
    LiverLiver LobulePerivenous HepatocytesLiver
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ALDH1B1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ALDH1B1

    SOURCE GeneReport for Unigene clusters: Hs.436219 Hs.743532

    UniProtKB/Swiss-Prot: AL1B1_HUMAN, P30837
    Tissue specificity: Liver, testis and to a lesser extent in brain

        SABiosciences Expression via Pathway-Focused PCR Array including ALDH1B1: 
              Drug Metabolism: Phase I Enzymes in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ALDH1B1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ALDH1B1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ALDH1B1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ALDH1B1
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALDH1B1

    Orthologs
    for ALDH1B1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for ALDH1B1 gene from 6/25 species (see all 25)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG37523 aldehyde dehydrogenase (NAD+) 66(a)   30B3   --
    worm
    (Caenorhabditis elegans)    		 Secernentea alh-16
    alh-26
    		 ALdehyde deHydrogenase family member (alh-2)
    		 64(a)
    63(a)
    		 many ↔ many
    many ↔ many
    		 III(5077725-5080636)
    V(1644169-1647728)
    A. gossypii yeast
    (Ashbya gossypii)    		 Saccharomycetes AGOS_ADR417W1 ADR417Wp 57.32(n)
    50.41(a)    		   4620677  NM_209865.1  NP_984512.1 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons ALDH2B71 aldehyde dehydrogenase 2B7 58.12(n)
    57.52(a)    		   838991  NM_102228.3  NP_564204.1 
    rice
    (Oryza sativa)    		 Liliopsida Os.24472 Oryza sativa (japonica cultivar-group) mRNA for aldehyde more 72.98(n)    AB044537.1 
    E. coli
    (Escherichia coli)    		 Gamma proteobacteria aldB6
    		 aldehyde dehydrogenase B
    		 39(a)
    		 possible ortholog
    		 Chromosome(3752996-3754534)


    ENSEMBL Gene Tree for ALDH1B1 (if available)
    TreeFam Gene Tree for ALDH1B1 (if available) 

    Paralogs
    for ALDH1B1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ALDH1B1 gene
    ALDH1L22  ALDH1A12  ENSG000002577672  ALDH1A22  ALDH7A12  ALDH22  ALDH16A12  ALDH8A12  
    ALDH9A12  ALDH1L12  ALDH1A32  
    12 SIMAP similar genes for ALDH1B1 using alignment to 1 protein entry:     AL1B1_HUMAN:
    ALDH1A2    ALDH1A1    ALDH2    ALDH1A3    ALDH1L1    ALDH1L2
    ALDH9A1    ALDH8A1    DKFZp686G1675    ALDH5A1    ALDH6A1    ALDH7A1

    ALDH1B1 for paralogs           About GeneDecksing



    Genomic Variants
    for ALDH1B1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/188 NCBI SNPs in ALDH1B1 are shown (see all 188)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 9 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs123432711,2
    		F,H,--38343292(+) GTTTCC/TAATGC 1 -- us2k15Minor allele frequency- T:0.01NS EA CSA 414
    rs588235741,2
    		F,--38343457(+) GGAGGC/TAGGAG 1 -- us2k11Minor allele frequency- T:0.06WA 118
    rs1122202201,2
    		C,--38343907(+) ACAGCG/AGCCGG 1 -- us2k12Minor allele frequency- A:0.17CSA WA 120
    rs608137841,2
    		--38344363(+) CAGCAA/CAACAG 1 -- us2k10--------
    rs754917241,2
    		F,--38344376(+) GTTACT/CATATG 1 -- us2k11Minor allele frequency- C:0.06NA 120
    rs1134502241,2
    		--38344670(+) AAAAGC/TGAGGG 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs101208201,2
    		C,F,--38344941(+) GCCGGG/CGGTAG 1 -- us2k11Minor allele frequency- C:0.16WA 118
    rs568157301,2
    		--38345108(+) TGTGGA/GCAGAG 1 -- ut510--------
    rs109737781,2
    		--38345608(+) AAAGCC/TAGGTT 1 -- int10--------
    rs1139159451,2
    		--38345649(+) TTCTTG/CCTGTG 1 -- int11Minor allele frequency- C:0.50CSA 2

    HapMap Linkage Disequilibrium report for ALDH1B1 (38392661 - 38398658 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for ALDH1B1
         1 CNV: 47939

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ALDH1B1
    DNA2.0 Custom Variant and Variant Library Synthesis for ALDH1B1

    Disorders / Diseases
    for ALDH1B1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ALDH1B1 for disorders           About GeneDecksing

    OMIM gene information: 100670    OMIM disorders: --

    5 diseases for ALDH1B1:    About MalaCards
    alcoholism    coronary heart disease    colon cancer    tuberculosis
    mycobacterium tuberculosis

    1 disease from the University of Copenhagen DISEASES database for ALDH1B1:
    Succinic semialdehyde dehydrogenase deficiency
    Human Genome Epidemiology (HuGE) Navigator: ALDH1B1 (7 documents)

    Export disorders for ALDH1B1 gene to outside databases

    Publications
    for ALDH1B1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ALDH1B1 gene, integrated from 9 sources (see all 38):
    (articles sorted by number of sources associating them with ALDH1B1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of a new functional human aldehyde dehydrogenase gene. (PubMed id 2061311)1, 2, 3, 9 Hsu L.C. and Chang W.-C. (1991)
    2. Diverse polymorphism within a short coding region of the human aldehyde dehydrogenase-5 (ALDH5) gene. (PubMed id 8244338)1, 2, 9 Sherman D.... Yoshida A. (1993)
    3. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Distribution of messenger RNAs for aldehyde dehydrogenase 1, aldehyde dehydrogenase 2, and aldehyde dehydrogenase 5 in human tissues. (PubMed id 8689400)1, 9 Stewart M.J....Crabb D.W. (1996)
    6. The novel aldehyde dehydrogenase gene, ALDH5, encodes an active aldehyde dehydrogenase enzyme. (PubMed id 7779080)1, 9 Stewart M.J....Crabb D.W. (1995)
    7. Molecular genetics of human aldehyde dehydrogenase. (PubMed id 1306115)1, 9 Yoshida A. (1992)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    9. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
    10. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)

    External Searches for ALDH1B1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ALDH1B1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 219 HGNC: 407 AceView: ALDH1B1 Ensembl:ENSG00000137124 euGenes: HUgn219
    ECgene: ALDH1B1 Kegg: 219 H-InvDB: ALDH1B1

    Other Databases showing ALDH1B1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ALDH1B1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ALDH1B1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ALDH1B1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ALDH1B1 gene:
    Search GeneIP for patents involving ALDH1B1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for ALDH1B1 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for ALDH1B1  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ALDH1B1   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ALDH1B1  
     OriGene Protein Over-expression Lysate for ALDH1B1   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for ALDH1B1   OriGene 3'-UTR Clone for ALDH1B1  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ALDH1B1   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ALDH1B1  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for ALDH1B1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ALDH1B1   OriGene Custom Protein Services for ALDH1B1  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ALDH1B1
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ALDH1B1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ALDH1B1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ALDH1B1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ALDH1B1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ALDH1B1
     GenScript Custom Purified and Recombinant Proteins Services for ALDH1B1 GenScript cDNA clones with any tag delivered in your preferred vector for ALDH1B1
     GenScript Custom Assay Services for ALDH1B1 GenScript Custom Superior Antibodies Services for ALDH1B1
     GenScript Custom overexpressing Cell Line Services for ALDH1B1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in ALDH1B1 promoter
     Search Chromatin IP Primers for ALDH1B1
     RT2 qPCR Primer Assay in human, mouse, rat ALDH1B1
     Search GNC Networks for ALDH1B1
     SABiosciences PCR Arrays including human, mouse, rat ALDH1B1
     Search Tocris compounds for ALDH1B1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     ALDH1B1 antibodies
     ALDH1B1 proteins
     ALDH1B1 lysates
     Antibodies for ALDH1B1
     See all of Abcam's Antibodies, Kits and Proteins for ALDH1B1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     ALDH1B1 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for ALDH1B1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALDH1B1
     SwitchGear 3'UTR luciferase reporter plasmids for ALDH1B1
     SwitchGear Promoter luciferase reporter plasmids for ALDH1B1
     ThermoFisher Antibodies for ALDH1B1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALDH1B1
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      ALDH1B1 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4