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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ALDH1B1 Gene

protein-coding   GIFtS: 69
GCID: GC09P038392

Aldehyde Dehydrogenase 1 Family, Member B1


(Previous symbol: ALDH5)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Aldehyde Dehydrogenase 1 Family, Member B11 2     Acetaldehyde Dehydrogenase 52
ALDH51 2 3 5     Aldehyde Dehydrogenase X, Mitochondrial2
Aldehyde Dehydrogenase 52 3     ALDH Class 22
ALDHX2 3     Aldehyde Dehydrogenase Family 1 Member B13
EC 1.2.1.33 8     EC 1.2.18

External Ids:    HGNC: 4071   Entrez Gene: 2192   Ensembl: ENSG000001371247   OMIM: 1006705   UniProtKB: P308373   

Export aliases for ALDH1B1 gene to outside databases

Previous GC identifers: GC09P038704 GC09P038562 GC09P038382 GC09P038345


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ALDH1B1 Gene:
This protein belongs to the aldehyde dehydrogenases family of proteins. Aldehyde dehydrogenase is the second
enzyme of the major oxidative pathway of alcohol metabolism. This gene does not contain introns in the coding
sequence. The variation of this locus may affect the development of alcohol-related problems. (provided by
RefSeq, Jul 2008)

GeneCards Summary for ALDH1B1 Gene: 
ALDH1B1 (aldehyde dehydrogenase 1 family, member B1) is a protein-coding gene. Diseases associated with ALDH1B1 include succinic semialdehyde dehydrogenase deficiency, and cardiovascular disease risk factor ), and among its related super-pathways are Ascorbate and aldarate metabolism and Valine, leucine and isoleucine degradation. GO annotations related to this gene include aldehyde dehydrogenase (NAD) activity. An important paralog of this gene is ALDH1L2.

UniProtKB/Swiss-Prot: AL1B1_HUMAN, P30837
Function: ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the
metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation

Gene Wiki entry for ALDH1B1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NT_008413.18  NC_018920.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ALDH1B1 gene promoter:
         USF1   USF2   USF-1:USF-2   NF-AT   NF-AT4   E2F-1   NF-AT2   USF-1   NF-AT3   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidALDH1B1 promoter sequence
   Search SABiosciences Chromatin IP Primers for ALDH1B1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ALDH1B1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p11.1   Ensembl cytogenetic band:  9p13.2   HGNC cytogenetic band: 9p13

ALDH1B1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ALDH1B1 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P038392:  view genomic region     (about GC identifiers)

Start:
38,392,661 bp from pter      End:
38,398,658 bp from pter
Size:
5,998 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: AL1B1_HUMAN, P30837 (See protein sequence)
Recommended Name: Aldehyde dehydrogenase X, mitochondrial precursor  
Size: 517 amino acids; 57206 Da
Subunit: Homotetramer (By similarity)
Subcellular location: Mitochondrion matrix
Secondary accessions: B2R8F0 Q8WX76 Q9BV45

Explore the universe of human proteins at neXtProt for ALDH1B1: NX_P30837

Explore proteomics data for ALDH1B1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P30837

  • 4/30 DME Specific Peptides for ALDH1B1 (P30837) (see all 30)
     TLELGGK  AGSRTFV  FVEESIY  VTLELGG 

    ALDH1B1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ALDH1B1 Protein Expression
    REFSEQ proteins: NP_000683.3  
    ENSEMBL proteins: 
     ENSP00000366927  

    Human Recombinant Protein Products for ALDH1B1: 
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    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005739mitochondrion IDA--
    GO:0005759mitochondrial matrix IEA--
    GO:0043231intracellular membrane-bounded organelle IDA--

    ALDH1B1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ALDH: Aldehyde dehydrogenases

    5 InterPro protein domains:
     IPR016162 Ald_DH_N
     IPR016163 Ald_DH_C
     IPR016161 Ald_DH/histidinol_DH
     IPR015590 Aldehyde_DH_dom
     IPR016160 Ald_DH_CS

    Graphical View of Domain Structure for InterPro Entry P30837

    ProtoNet protein and cluster: P30837

    1 Blocks protein domain: IPB002086 Aldehyde dehydrogenase

    UniProtKB/Swiss-Prot: AL1B1_HUMAN, P30837
    Similarity: Belongs to the aldehyde dehydrogenase family


    ALDH1B1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AL1B1_HUMAN, P30837
    Function: ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the
    metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation
    Catalytic activity: An aldehyde + NAD(+) + H(2)O = a carboxylate + NADH

         Enzyme Numbers (IUBMB): EC 1.2.1.31 2 EC 1.2.12

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004029aldehyde dehydrogenase (NAD) activity IEA--
    GO:0016491oxidoreductase activity ----
         
    ALDH1B1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ALDH1B1:
     Upregulation of Wnt/beta-caten 

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ALDH1B1 About   (see all 13)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Glucuronidation
    Ascorbate and aldarate metabolism0.61
    Pentose and glucuronate interconversions0.61
    2Branched-chain amino acid catabolism
    Valine, leucine and isoleucine degradation0.39
    Propanoate metabolism0.31
    3Tyrosine metabolism p.1 (dopamine)
    Tyrosine metabolism p.1 (dopamine)1.00
    4Tryptophan metabolism
    Tryptophan metabolism0.46
    5Glycolysis and gluconeogenesis (short map)
    Glycolysis / Gluconeogenesis0.46

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for ALDH1B1
        Tyrosine metabolism p.1 (dopamine)


    1 GeneGo (Thomson Reuters) Pathway for ALDH1B1
        Tyrosine metabolism p.1 (dopamine)



    5/14         Kegg Pathways  (Kegg details for ALDH1B1) (see all 14):
        Glycolysis / Gluconeogenesis
    Pentose and glucuronate interconversions
    Ascorbate and aldarate metabolism
    Fatty acid degradation
    Valine, leucine and isoleucine degradation

    UniProtKB/Swiss-Prot: AL1B1_HUMAN, P30837
    Pathway: Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2


    ALDH1B1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ALDH1B1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/328 Interacting proteins for ALDH1B1 (P308372, 3 ENSP000003669274) via UniProtKB, MINT, STRING, and/or I2D (see all 328)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYCP011063, ENSP000003672074I2D: score=3 STRING: ENSP00000367207
    ENSG00000258947Q135093I2D: score=1 
    TUBB3Q135093I2D: score=1 
    CADP277083, ENSP000002647054I2D: score=1 STRING: ENSP00000264705
    ICT1Q141972, ENSP000003015854MINT-8079030 STRING: ENSP00000301585
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process NAS1306115
    GO:0006068ethanol catabolic process IEA--
    GO:0008152metabolic process ----
    GO:0055114oxidation-reduction process ----

    ALDH1B1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ALDH1B1 (AL1B1)

    10/41 HMDB Compounds for ALDH1B1 (see all 41)    About this table
    CompoundSynonyms CAS #PubMed Ids
    (S)-Methylmalonic acid semialdehyde(S)-Methylmalonate semialdehyde (see all 3)99043-16-0--
    1-Butanol1-Butanol (see all 10)71-36-3--
    1-Hexanol1-Hexyl alcohol (see all 30)111-27-3--
    1-Pentanol1-Pentol (see all 34)71-41-0--
    2-Propyn-1-al ----
    20-Oxo-leukotriene E420-oxo-LTE(,4) (see all 3)----
    20-oxo-leukotriene B420-carboxyleukotriene B4 ----
    3-Butyn-1-al 52844-23-2--
    3a,7a-Dihydroxy-5b-cholestan-26-al3a,7a-Dihydroxy-5b-cholestan-26-al;3alpha,7alpha-dihydroxy-5beta-cholestan-27-al;5beta-cholestane-3alpha,7alpha-diol-27-al;5beta-cholestan-27-al-3alpha,7alpha-diol ----
    4-Acetamidobutanoic acidN-Acetyl-4-aminobutanoate (see all 11)3025-96-5--

    1 DrugBank Compound for ALDH1B1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    NADHbeta-DPNH (see all 18)606-68-8target--17139284 17016423

    Search CenterWatch for drugs/clinical trials and news about ALDH1B1 / AL1B1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ALDH1B1 gene: 
    NM_000692.4  

    Unigene Clusters for ALDH1B1:

    Aldehyde dehydrogenase 1 family, member B1
    Hs.436219  [show with all ESTs], Hs.743532  [show with all ESTs]
    Unigene Representative Sequences: NM_000692, BT007418
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000377698(uc004aay.3)
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    Additional mRNA sequence: 

    BC127734.1 BT007418.1 

    4 DOTS entries:

    DT.443359  DT.97848183  DT.75103462  DT.121167274 

    24/149 AceView cDNA sequences (see all 149):

    AI520967 CA429736 AL135209 BI850371 BM917091 AA305312 AI476617 NM_000692 
    BU194396 BU074303 BG772274 AA918488 BG170859 BT007418 BM458404 BG178113 
    BQ877668 BE889631 AL600659 BI856109 BU149773 BF222449 BM972125 AA102707 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for ALDH1B1    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b
    SP1:                              
    SP2:              -               


    ECgene alternative splicing isoforms for ALDH1B1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ALDH1B1 expression in normal human tissues (normalized intensities)      ALDH1B1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATTAACTCC
    ALDH1B1 Expression
    About this image


    ALDH1B1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/8 selected tissues (see all 8) fully expand
     
     Liver (Hepatobiliary System)    fully expand to see all 2 entries
             Periportal Hepatocytes Liver Lobule
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Trigeminal Ganglion   
     
     Lower Urinary Tract (Urinary System)
             bladder   
     
     Heart (Cardiovascular System)
             Atrioventricular Node
     
     Ovary (Reproductive System)
             Pre-Granulosa Cells Primordial Follicle

    See ALDH1B1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ALDH1B1

    SOURCE GeneReport for Unigene clusters: Hs.436219 Hs.743532

    UniProtKB/Swiss-Prot: AL1B1_HUMAN, P30837
    Tissue specificity: Liver, testis and to a lesser extent in brain

        SABiosciences Expression via Pathway-Focused PCR Array including ALDH1B1: 
              Drug Metabolism: Phase I Enzymes in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ALDH1B1 gene from 6/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Aldh1b11 , 5 aldehyde dehydrogenase 1 family, member B11, 5 87.12(n)1
    94.37(a)1
      4 (24.35 cM)5
    725351  NM_028270.41  NP_082546.11 
     457990225 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG37523 aldehyde dehydrogenase (NAD+) 66(a)   30B3   --
    worm
    (Caenorhabditis elegans)
    Secernentea alh-16
    alh-26
    Protein ALH-2
    63(a)
    62(a)
    many ↔ many
    many ↔ many
    III(5077763-5080674)
    V(1644169-1647728)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ALD4(YOR374W)4 Mitochondrial aldehyde dehydrogenase, required for more   --   15(1039840-1041399) 854556  NP_015019.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ALDH2B71 aldehyde dehydrogenase 2B7 58.12(n)
    57.52(a)
      838991  NM_102228.3  NP_564204.1 
    rice
    (Oryza sativa)
    Liliopsida Os.24472 Oryza sativa (japonica cultivar-group) mRNA for aldehyde more 72.98(n)    AB044537.1 


    ENSEMBL Gene Tree for ALDH1B1 (if available)
    TreeFam Gene Tree for ALDH1B1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ALDH1B1 gene
    ALDH1L22  ALDH1A12  ENSG000002577672  ALDH1A22  ALDH7A12  ALDH6A12  ALDH22  ALDH8A12  
    ALDH9A12  ALDH1L12  ALDH1A32  
    12 SIMAP similar genes for ALDH1B1 using alignment to 1 protein entry:     AL1B1_HUMAN:
    ALDH1A2    ALDH2    ALDH1A1    ALDH1A3    ALDH1L1    ALDH1L2
    ALDH9A1    ALDH8A1    DKFZp686G1675    ALDH5A1    ALDH6A1    ALDH7A1

    ALDH1B1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/230 SNPs in ALDH1B1 are shown (see all 230)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs123432711,2
    C,F,H--38358362(+) GTTTCC/TAATGC 1 -- us2k15Minor allele frequency- T:0.01NS EA CSA 414
    rs107389971,2
    C,F,A,H--38358377(+) TAACAT/CGAGGA 1 -- us2k123Minor allele frequency- C:0.34NS EA NA WA CSA 2226
    rs588235741,2
    F--38358527(+) GGAGGC/TAGGAG 1 -- us2k11Minor allele frequency- T:0.06WA 118
    rs1428951911,2
    --38358556(+) ATGCCA/GTTGCT 1 -- us2k10--------
    rs1853035221,2
    --38358609(+) CCAATC/TATAGT 1 -- us2k10--------
    rs48788021,2
    C,F,A,H--38358658(+) AACATC/GCTAAG 1 -- us2k118Minor allele frequency- G:0.32NS EA NA WA CSA 795
    rs1507877681,2
    C--38358818(+) GTGCCA/GGAGGC 1 -- us2k10--------
    rs1391566461,2
    --38358961(+) AGGAGC/GGGCTA 1 -- us2k10--------
    rs1499243711,2
    C--38358962(+) GGAGCA/GGCTAC 1 -- us2k10--------
    rs1122202201,2
    C--38358977(+) ACAGCG/AGCCGG 1 -- us2k12Minor allele frequency- A:0.17CSA WA 120

    HapMap Linkage Disequilibrium report for ALDH1B1 (38392661 - 38398658 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ALDH1B1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv527063CNV Loss19592680
    esv34172CNV Loss18971310
    nsv893066CNV Gain21882294
    nsv8445CNV Gain+Loss18304495

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 100670    OMIM disorders: --

    6 diseases for ALDH1B1:    About MalaCards
    succinic semialdehyde dehydrogenase deficiency    cardiovascular disease risk factor )    alcoholism    coronary heart disease
    tuberculosis    colon cancer

    1 disease from the University of Copenhagen DISEASES database for ALDH1B1:
    Succinic semialdehyde dehydrogenase deficiency

    ALDH1B1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ALDH1B1
    Human Genome Epidemiology (HuGE) Navigator: ALDH1B1 (7 documents)

    Export disorders for ALDH1B1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ALDH1B1 gene, integrated from 9 sources (see all 42):
    (articles sorted by number of sources associating them with ALDH1B1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of a new functional human aldehyde dehydrogenase gene. (PubMed id 2061311)1, 2, 3, 9 Hsu L.C. and Chang W.-C. (1991)
    2. Diverse polymorphism within a short coding region of the human aldehyde dehydrogenase-5 (ALDH5) gene. (PubMed id 8244338)1, 2, 9 Sherman D.... Yoshida A. (1993)
    3. Genetic determinants of both ethanol and acetaldehyde metabolism influence alcohol hypersensitivity and drinking behaviour among Sca ndinavians. (PubMed id 20205700)1, 4 Linneberg A....Husemoen L.L. (2010)
    4. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064)1, 4 He C....Hunter D.J. (2010)
    5. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    6. The association of alcohol and alcohol metabolizing g ene variants with diabetes and coronary heart disease risk factors in a white p opulation. (PubMed id 20700531)1, 4 Husemoen L.L....Linneberg A. (2010)
    7. Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PubMed id 19343046)1, 4 Saito A....Kamatani N. (2009)
    8. Contribution of the alcohol dehydrogenase-1B genotype and oral microorganisms to high salivary acetaldehyde concentrations in Japanese alcoholic men. (PubMed id 17471563)1, 4 Yokoyama A....Yokoyama T. (2007)
    9. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 219 HGNC: 407 AceView: ALDH1B1 Ensembl:ENSG00000137124 euGenes: HUgn219
    ECgene: ALDH1B1 Kegg: 219 H-InvDB: ALDH1B1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ALDH1B1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ALDH1B1 gene:
    Search GeneIP for patents involving ALDH1B1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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