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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ALDH1A3 Gene

protein-coding GIFtS: 63
GCID: GC15P101419

aldehyde dehydrogenase 1 family, member A3

(Previous symbol: ALDH6)

Explore 11 diseases affiliated with
ALDH1A3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Aldehyde Dehydrogenase 1 Family, Member A3¹ ²		ALDH1A6²
ALDH6¹ ² ³ ⁵		Acetaldehyde Dehydrogenase 6²
RALDH3¹ ²		Aldehyde Dehydrogenase Family 1 Member A3²
Aldehyde Dehydrogenase 6² ³		EC 1.2.1.5³
Retinaldehyde Dehydrogenase 3² ³		RalDH3³
RALDH-3² ³		EC 1.2.1⁸

External Ids:	HGNC: 409¹	Entrez Gene: 220²	Ensembl: ENSG00000184254⁷	OMIM: 600463⁵	UniProtKB: P47895³

Export aliases for ALDH1A3 gene to outside databases

Previous GC identifers: GC15P098102 GC15P095259 GC15P099012 GC15P099156 GC15P099157 GC15P099237 GC15P077542

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ALDH1A3:

Aldehyde dehydrogenase isozymes are thought to play a major role in the detoxification of aldehydes generated by

alcohol metabolism and lipid peroxidation. The enzyme encoded by this gene uses retinal as a substrate, either in a

free or cellular retinol-binding protein form. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: AL1A3_HUMAN, P47895

Function: Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Seems to be the key

enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development and also in

the development of the olfactory system (By similarity)

Gene Wiki entry for ALDH1A3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000015.9 NC_018926.1 NT_010274.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ALDH1A3 gene promoter:
HOXA9 HOXA9B CUTL1 Meis-1b POU2F1 POU2F1a Meis-1 ATF6
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ALDH1A3 promoter sequence

Search SABiosciences Chromatin IP Primers for ALDH1A3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ALDH1A3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q26.3 Ensembl cytogenetic band: 15q26.3 HGNC cytogenetic band: 15q26

ALDH1A3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ALDH1A3 gene location

GeneLoc information about chromosome 15 GeneLoc Exon Structure

GeneLoc location for GC15P101419: view genomic region (about GC identifiers)

Start:	101,402,129 bp from pter	End:	101,456,831 bp from pter
Size:	54,703 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: AL1A3_HUMAN, P47895 (See protein sequence)

Recommended Name: Aldehyde dehydrogenase family 1 member A3

Size: 512 amino acids; 56108 Da

Subcellular location: Cytoplasm (By similarity)

Secondary accessions: Q6NT64

Explore the universe of human proteins at neXtProt for ALDH1A3: NX_P47895

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P47895

4/19 DME Specific Peptides for ALDH1A3 (P47895) (see all 19)

TLELGGK

RHEPIGV

ITPWNFP

VTLELGG

ALDH1A3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_000684.2

ENSEMBL proteins:

ENSP00000452789 ENSP00000332256 ENSP00000454107 ENSP00000453328 ENSP00000343294

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	Uscn Proteins for ALDH1A3

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IDA	11585737

ALDH1A3 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ALDH1A3 for domains About GeneDecksing

5 InterPro domains/families:

IPR016162 Ald_DH_N

IPR016163 Ald_DH_C

IPR016161 Ald_DH/histidinol_DH

IPR015590 Aldehyde_DH_dom

IPR016160 Ald_DH_CS

Graphical View of Domain Structure for InterPro Entry P47895

ProtoNet protein and cluster: P47895

1 Blocks protein family: IPB002086 Aldehyde dehydrogenase

UniProtKB/Swiss-Prot: AL1A3_HUMAN, P47895

Similarity: Belongs to the aldehyde dehydrogenase family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: AL1A3_HUMAN, P47895

Function: Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Seems to be the key

enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development and also in

the development of the olfactory system (By similarity)

Catalytic activity: An aldehyde + NAD(P)(+) + H(2)O = a carboxylate + NAD(P)H

Enzyme Numbers (IUBMB): EC 1.2.1² EC 1.2.1.5¹

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		8/28 QIAGEN miScript miRNA Assays for microRNAs that regulate ALDH1A3 (see all 28):
		hsa-miR-125a-5p hsa-miR-106a hsa-miR-4263 hsa-miR-340 hsa-miR-144 hsa-miR-125b hsa-miR-93 hsa-miR-29a*

		SwitchGear 3'UTR luciferase reporter plasmid: ALDH1A3 3' UTR sequence

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In Situ Assay
Products:

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Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004029	aldehyde dehydrogenase (NAD) activity	IEA	--
GO:0004030	aldehyde dehydrogenase [NAD(P)+] activity	IDA	11585737
GO:0016491	oxidoreductase activity	--	--
GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	--	--
GO:0042803	protein homodimerization activity	IDA	11585737

ALDH1A3 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-outs for ALDH1A3: Aldh1a3^tm1Gdu Aldh1a3^tm1.1Pcn
     9 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Aldh1a3):

craniofacial	embryogenesis	endocrine/exocrine gland	mortality/aging	normal
renal/urinary system	respiratory system	skeleton	vision/eye

ALDH1A3 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Retinol metabolism

Retinol metabolism

1.00

Retinol metabolism

0.95

Drug metabolism - cytochrome P450

Drug metabolism - cytochrome P450

1.00

Metabolism of xenobiotics by cytochrome P450

0.73

Tyrosine metabolism

Tyrosine metabolism

1.00

Phenylalanine metabolism

0.35

Vitamin A and carotenoid metabolism

Vitamin A and carotenoid metabolism

1.00

beta-Alanine metabolism

beta-Alanine metabolism

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for ALDH1A3

Retinol metabolism

1 GeneGo (Thomson Reuters) Pathway for ALDH1A3

Retinol metabolism

2 BioSystems Pathways for ALDH1A3

	Vitamin A and carotenoid metabolism
	retinoate biosynthesis I

5/8 Kegg Pathways (Kegg details for ALDH1A3) (see all 8):

	Glycolysis / Gluconeogenesis
	Histidine metabolism
	Tyrosine metabolism
	Phenylalanine metabolism
	beta-Alanine metabolism

UniProtKB/Swiss-Prot: AL1A3_HUMAN, P47895

Pathway: Cofactor metabolism; retinol metabolism

ALDH1A3 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ALDH1A3

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/47 Interacting proteins for ALDH1A3 (ENSP00000332256⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 47)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ABAT	ENSP00000268251⁴	STRING: ENSP00000268251
ACSS1	ENSP00000316924⁴	STRING: ENSP00000316924
ACSS2	ENSP00000353804⁴	STRING: ENSP00000353804
ADH1A	ENSP00000209668⁴	STRING: ENSP00000209668
ADH4	ENSP00000265512⁴	STRING: ENSP00000265512

About this table

Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001822	kidney development	--	--
GO:0002072	optic cup morphogenesis involved in camera-type eye development	IEA	--
GO:0002138	retinoic acid biosynthetic process	IEA	--
GO:0021768	nucleus accumbens development	IEA	--
GO:0021983	pituitary gland development	--	--

ALDH1A3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

ALDH1A3 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ALDH1A3

10/42 HMDB Compounds for ALDH1A3 (see all 42) About this table

Compound	Synonyms	CAS #	PubMed Ids
(S)-Methylmalonic acid semialdehyde	(S)-Methylmalonate semialdehyde (see all 3)	99043-16-0	--
2-Propyn-1-al		--	--
3,4-Dihydroxybenzeneacetic acid	(3,4-Dihydroxyphenyl)acetate (see all 23)	102-32-9	--
3,4-Dihydroxymandelaldehyde	3,4-Dihydroxyphenylglycolaldehyde (see all 4)	13023-73-9	--
3,4-Dihydroxyphenylacetaldehyde	Protocatechuatealdehyde (see all 2)	5707-55-1	--
3-Butyn-1-al		52844-23-2	--
3-Methoxy-4-hydroxyphenylglycolaldehyde	a,4-dihydroxy-3-methoxy-Benzeneacetaldehyde (see all 4)	17592-23-3	--
3a,7a-Dihydroxy-5b-cholestan-26-al	3a,7a-Dihydroxy-5b-cholestan-26-al;3alpha,7alpha-dihydroxy-5beta-cholestan-27-al;5beta-cholestane-3alpha,7alpha-diol-27-al;5beta-cholestan-27-al-3alpha,7alpha-diol	--	--
4-Acetamidobutanoic acid	N-Acetyl-4-aminobutanoate (see all 11)	3025-96-5	--
4-Aminobutyraldehyde	4-amino-butanal (see all 5)	4390-05-0	--

2 DrugBank Compounds for ALDH1A3 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Vitamin A	[11,12-3H]-Retinol (see all 18)	68-26-8	target	--	17270546 15950969 17184764 17486539
NADH	beta-DPNH (see all 18)	606-68-8	target	--	17139284 17016423 16241904

5 Novoseek chemical compound relationships for ALDH1A3 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
retinaldehyde	90.3	9	11013254 (2), 11044606 (2), 11585737 (1), 16241904 (1)
retinoic acid	67.1	19	11585737 (6), 17526768 (2), 12734205 (1), 10906479 (1) (see all 7)
vitamin a	48.6	2	11585737 (1), 12734205 (1)
nad+	47.7	4	16241904 (3), 17526768 (1)
testosterone	19.6	7	17526768 (4)

Search CenterWatch for drugs/clinical trials and news about ALDH1A3 / AL1A3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ALDH1A3 gene:

NM_000693.2

Unigene Cluster for ALDH1A3:

Aldehyde dehydrogenase 1 family, member A3

Hs.459538 [show with all ESTs]

Unigene Representative Sequence: NM_000693

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000558568 ENST00000561338 ENST00000329841(uc002bwn.4 uc010bpb.3)

ENST00000558033 ENST00000557963 ENST00000560555 ENST00000346623 ENST00000558869

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		hsa-miR-125a-5p hsa-miR-106a hsa-miR-4263 hsa-miR-340 hsa-miR-144 hsa-miR-125b hsa-miR-93 hsa-miR-29a*

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Additional cDNA sequence:

AK302607.1 AK303441.1 AK312303.1 AL110109.1 BC069274.1 BX538027.1 U07919.1 Z36841.1

9 DOTS entries:

DT.217181 DT.95082437 DT.99997060 DT.91747481 DT.95082447 DT.99971929 DT.100700428 DT.92044922

DT.92045698

24/190 AceView cDNA sequences (see all 190):

CD609396 BM848050 BU684417 BQ888780 N44575 BU158010 BC069274 CB850644

BM782307 AI810988 CB241289 AA371048 AI659909 BC009245 BQ889473 AA377896

AA662776 AW292401 BF064248 BU166953 BU607923 CK430242 BM969873 CD723451

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for ALDH1A3 About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13
SP1:
SP2:									-		-		-

ECgene alternative splicing isoforms for ALDH1A3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ALDH1A3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATAAAATGG

About this image

ALDH1A3 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10/22 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 22)

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Eye

Retinal Pigmented Epithelium

Retinal Pigmented Epithelium Progenitor Cells

Retinal Pigmented Epithelium

Reproductive System

Ectoderm, Epidermis

Adult Endothelial Cells

Blood Brain Barrier, Endothelium

Brain

Blood Brain Barrier

Endothelial Cells

Blood Brain Barrier, Endothelium

Gut Tube

Midgut

Midgut Endoderm Cells

Endoderm

Kidney

Ureteric Bud Tip Cells

Kidney

Limb

Stylopod Synovial Joint

Interzone Cells

Cartilage

Bone

Maxillary Process

Bone

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 10/11 LifeMap Cells (see all 11)

Name

Category

PureStem™ endothelial Progenitor 30-SM2-3 (Embryonic Progenitor Cell)

Blood, Endothelium

PureStem™ endothelial progenitor 30-SM2-1 (Embryonic Progenitor Cell)

Endothelium

PureStem™ endothelial progenitor RP1-MV2-18 (Embryonic Progenitor Cell)

Endothelium

PureStem™ mesenchymal progenitor 4D20.8 (Embryonic Progenitor Cell)

Lateral Plate Mesoderm, Neural Crest

PureStem™ progenitor E44 (Embryonic Progenitor Cell)

PureStem™ progenitor EN27 (Embryonic Progenitor Cell)

PureStem™ progenitor F15 (Embryonic Progenitor Cell)

Blimp1- mVenus and stella-ECFP genetically modified stem cells (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

N2/LSB induced-cells (Generation of midbra...)

Definitive endoderm-like cells (A scalable, suspensi...)

See ALDH1A3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ALDH1A3

SOURCE GeneReport for Unigene cluster: Hs.459538

UniProtKB/Swiss-Prot: AL1A3_HUMAN, P47895

Tissue specificity: Expressed at low levels in many tissues and at higher levels in salivary gland, stomach, and kidney

SABiosciences Expression via Pathway-Focused PCR Arrays including ALDH1A3:

Cellular Senescence in human mouse rat

Drug Metabolism: Phase I Enzymes in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALDH1A3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the last universal common ancestor (LUCA).

Orthologs for ALDH1A3 gene from 8/25 species (see all 25) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Aldh1a3^{1 , 5}	aldehyde dehydrogenase family 1, subfamily A3^{1, 5}	87.24(n)¹ 93.95(a)¹		7 (35.73 cM)⁵ 56847¹ NM_053080.3¹ NP_444310.3¹ 66390892⁵
chicken (Gallus gallus)	Aves	ALDH1A3¹	aldehyde dehydrogenase 1 family, member A3	77.54(n) 86.13(a)		395389 NM_204669.1 NP_990000.1
lizard (Anolis carolinensis)	Reptilia	ALDH1A3⁶	--	77(a)	1 ↔ 1	GL343383.1(953289-994484)
zebrafish (Danio rerio)	Actinopterygii	aldh1a3¹	aldehyde dehydrogenase 1 family, member A3	68.25(n) 70.75(a)		751785 NM_001044745.1 NP_001038210.1
fruit fly (Drosophila melanogaster)	Insecta	CG3752³	aldehyde dehydrogenase (NAD+)	61(a)		30B3 --
thale cress (Arabidopsis thaliana)	eudicotyledons	ALDH2B4⁶ ALDH2B7⁶ (see all 5)	aldehyde dehydrogenase 2B7 (see all 5)	52(a) 52(a) (see all 5)	many ↔ many many ↔ many (see all 5)	3(17716867-17720020) 1(8412051-8414879)
rice (Oryza sativa)	Liliopsida	-- -- (see all 7)	aldehyde dehydrogenase, putative, expressed (see all 7)	51(a) 50(a) (see all 7)	many ↔ many many ↔ many (see all 7)	6(23288527-23291318) 1(23096212-23105259)
E. coli (Escherichia coli)	Gamma proteobacteria	aldB⁶	aldehyde dehydrogenase B	38(a)	possible ortholog	Chromosome(3752996-3754534)

ENSEMBL Gene Tree for ALDH1A3 (if available)
TreeFam Gene Tree for ALDH1A3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for ALDH1A3 gene

ALDH1L2² ALDH1A1² ALDH1A2² ENSG00000257767² ALDH1B1² ALDH7A1² ALDH2² ALDH16A1²

ALDH8A1² ALDH9A1² ALDH1L1²

12 SIMAP similar genes for ALDH1A3 using alignment to 5 protein entries: AL1A3_HUMAN (see all proteins):

DKFZp686G1675 ALDH1A2 ALDH1A1 ALDH2 ALDH1B1 ALDH1L1

ALDH1L2 ALDH9A1 ALDH8A1 ALDH5A1 ALDH6A1 ALDH7A1

ALDH1A3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 15 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs74041812^1,2	C,	--	77540619(+)	`TCACCC/TGTAAA`	1	--	us2k¹		2		WA	120
rs151193202^1,2		--	101418028(+)	`GGCTC-/CTGAGACCAG ACGCCTCGGGTCACAAGG`	1	--	us2k¹		0	--	--	--	--
rs192786763^1,2		--	101418136(+)	`CAAACA/GGGCTC`	1	--	us2k¹		0	--	--	--	--
rs141240747^1,2		--	101418223(+)	`TAACAC/GAGTTT`	1	--	us2k¹		0	--	--	--	--
rs201820845^1,2		--	101418250(+)	`TCAGA-/TTTTTT`	1	--	us2k¹		0	--	--	--	--
rs182901234^1,2		--	101418260(+)	`TTTTTA/TAAATC`	1	--	us2k¹		0	--	--	--	--
rs188459236^1,2		--	101418301(+)	`ACCCCC/TGATAA`	1	--	us2k¹		0	--	--	--	--
rs3809527^1,2	C,F,H,	--	101418335(-)	`GATGCT/CTTACA`	1	--	us2k¹		10		NA WA EA	372
rs192127067^1,2		--	101418340(+)	`AGCATC/TTCTAG`	1	--	us2k¹		0	--	--	--	--
rs3809526^1,2	C,F,A,H,	--	101418341(-)	`ACTAGG/AGATGC`	1	--	us2k¹		14		NA WA CSA EA	377

HapMap Linkage Disequilibrium report for ALDH1A3 (101402129 - 101456831 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 12 variations for ALDH1A3
3 CNVs: 2201 72379 102186
9 Indels: 45395 25599 42429 40124 11819 25601 61482 25600 42898

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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ALDH1A3 for disorders           About GeneDecksing

OMIM gene information: 600463    OMIM disorders: --

11 diseases for ALDH1A3:    About MalaCards

retinol binding protein choanal atresia retinitis polycystic ovary syndrome

alcoholism prostate cancer breast cancer prostatitis

tuberculosis thyroiditis mycobacterium tuberculosis

Human Genome Epidemiology (HuGE) Navigator: ALDH1A3 (2 documents)

Export disorders for ALDH1A3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for ALDH1A3 gene, integrated from 9 sources (see all 30):
(articles sorted by number of sources associating them with ALDH1A3)

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Molecular cloning, genomic organization, and chromosomal localization of an additional human aldehyde dehydrogenase gene, ALDH6. (PubMed id 7698756)^{1, 2, 3, 9} Hsu L.C.... Hsieh C.-L. (1994)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Retinoic acid biosynthesis by normal human breast epithelium is via aldehyde dehydrogenase 6, absent in MCF-7 cells. (PubMed id 11585737)^{1, 9} Rexer B.N....Ong D.E. (2001)
Characterization of retinaldehyde dehydrogenase 3. (PubMed id 16241904)^{7, 9} Graham C.E....Warren M.J. (2006)
Aldehyde dehydrogenase activity is a biomarker of prim itive normal human mammary luminal cells. (PubMed id 22131125)¹ Eirew P....Eaves C.J. (2012)
Aldehyde dehydrogenase activity of breast cancer stem cells is primarily due to isoform ALDH1A3 and its expression is predictive of metastasis. (PubMed id 21280157)¹ Marcato P....Lee P.W. (2011)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
Aldehyde dehydrogenase 1A3 is transcriptionally activ ated by all-trans-retinoic acid in human epidermal keratinocytes. (PubMed id 20709019)¹ Koenig U....Tschachler E. (2010)
Consequences of lineage-specific gene loss on functio nal evolution of surviving paralogs: ALDH1A and retinoic acid signaling in vert ebrate genomes. (PubMed id 19478994)¹ CaA+estro C....Postlethwait J.H. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 220	HGNC: 409	AceView: ALDH1A3	Ensembl:ENSG00000184254	euGenes: HUgn220
ECgene: ALDH1A3	Kegg: 220	H-InvDB: ALDH1A3

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for ALDH1A3	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ALDH1A3 gene
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Patent Information for ALDH1A3 gene:
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aldehyde dehydrogenase 1 family, member A3

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ALDH1A3 Gene

aldehyde dehydrogenase 1 family, member A3

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