ALDH1A2 Gene

Aliases
for ALDH1A2 gene

Previous GC identifers: GC15M053802 GC15M051292 GC15M055824 GC15M055961 GC15M056032 GC15M035068

Summaries
for ALDH1A2 gene

Genomic Views
for ALDH1A2 gene

RefSeq DNA sequence:

NC_000015.9  NC_018926.1  NT_010194.17  

SwitchGear Promoter luciferase reporter plasmid: ALDH1A2 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ALDH1A2

ALDH1A2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M058245:  view genomic region     (about GC identifiers)

Proteins
for ALDH1A2 gene

Explore the universe of human proteins at neXtProt for ALDH1A2: NX_O94788

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Proteins (see all 2): ALDH1A2 OriGene Protein Over-expression Lysate (see all 5): ALDH1A2 OriGene Custom Protein Services for ALDH1A2
	GenScript Custom Purified and Recombinant Proteins Services for ALDH1A2
	Novus Biologicals ALDH1A2 Protein Novus Biologicals ALDH1A2 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for ALDH1A2

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	OriGene Antibodies: ALDH1A2 OriGene Custom Antibody Services for ALDH1A2
	GenScript Custom Superior Antibodies Services for ALDH1A2
	Novus Biologicals ALDH1A2 Antibodies
	Abcam antibodies for ALDH1A2
	Uscn Antibodies for ALDH1A2
	ThermoFisher Antibodies for ALDH1A2

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for ALDH1A2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for ALDH1A2

Protein Domains /
Families
for ALDH1A2 gene

ProtoNet protein and cluster: O94788

Function
for ALDH1A2 gene

Enzyme Numbers (IUBMB): EC 1.2.1.36^{1 2} EC 1.2.1²

miRNA Products:		OriGene 3'-UTR Clone (see all 3): ALDH1A2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ALDH1A2
		8/31 QIAGEN miScript miRNA Assays for microRNAs that regulate ALDH1A2 (see all 31):
		hsa-miR-2052 hsa-miR-4307 hsa-miR-19b-2* hsa-miR-137 hsa-miR-449c* hsa-miR-340 hsa-miR-4267 hsa-miR-23a
		SwitchGear 3'UTR luciferase reporter plasmid: ALDH1A2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ALDH1A2 (see all 7) OriGene shRNA RFP: ALDH1A2 OriGene siRNA: ALDH1A2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ALDH1A2

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for ALDH1A2

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ALDH1A2 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ALDH1A2 (see all 4) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): ALDH1A2 (NM_003888)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for ALDH1A2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALDH1A2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ALDH1A2
		LifeMap BioReagents: cell line associated with ALDH1A2: PureStem MEL2, NCr-fac Progenitor

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALDH1A2

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

15/19 MGI mutant phenotypes (inferred from 6 alleles) (MGI details for Aldh1a2)

Pathways & Interactions
for ALDH1A2 gene

	Super-pathway	contained gene-specific pathways
1	Retinol metabolism	Retinol metabolism 1.00 Retinol metabolism 0.95
2	Vitamin A and carotenoid metabolism	Vitamin A and carotenoid metabolism 1.00
3	Tryptophan metabolism	Tryptophan metabolism 1.00
4	Drug metabolism - cytochrome P450	Retinol metabolism 0.40
5	Metabolism	Metabolic pathways 0.38

1 EMD Millipore Pathway for ALDH1A2

Retinol metabolism

1 GeneGo (Thomson Reuters) Pathway for ALDH1A2

Retinol metabolism

3 BioSystems Pathways for ALDH1A2

	Vitamin A and carotenoid metabolism
	Tryptophan metabolism
	retinoate biosynthesis I

2         Kegg Pathways  (Kegg details for ALDH1A2)

	Retinol metabolism
	Metabolic pathways

ALDH1A2 for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for ALDH1A2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/55 Interacting proteins for ALDH1A2 (O94788³ ENSP00000249750⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 55)

Gene Ontology (GO): 5/40 biological process terms (GO ID links to tree view) (see all 40):    About this table

Drugs & Compounds
for ALDH1A2 gene

Transcripts
for ALDH1A2 gene

Expression
for ALDH1A2 gene

ALDH1A2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTCCAAGTG

10/23 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 23)
	Tissue Anatomical Compartment Cell			Category (developmental path)
	HeartEpicardiumEpicardial Progenitors Cells			Epicardium
	HeartInflow TractInflow Progenitors			Myocardium
	HeartOutflow EpicardiumOutflow Epicardial Progenitors			Epicardium
	Spinal CordCaudal Brachial Lateral Motor ColumnLateral Motor Neurons			Motor Neurons
	Spinal CordLumbar Lateral Motor ColumnLateral Motor Neurons			Motor Neurons
	Spinal CordRostral Brachial Lateral Motor ColumnLateral Motor Neurons			Motor Neurons
	BrainAnterior MeningesMeningeal Cells			Meninges
	BrainChoroid PlexusMature Choroid Plexus Cells			Choroid Plexus
	EyeRetinal Pigmented EpitheliumRetinal Pigmented Epithelium Progenitor Cells			Retinal Pigmented Epithelium
	Lateral Plate MesodermEmbryonic Capillary PlexusAngioblasts			Endothelium
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 2 LifeMap Cells
	Name			Category
	PureStem™ mesenchymal progenitor MEL2 (Embryonic Progenitor Cell)			Adipose, Bone, Cartilage
	Beating cell clusters (Spontaneous differen...)

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ALDH1A2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ALDH1A2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ALDH1A2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ALDH1A2

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALDH1A2

Orthologs
for ALDH1A2 gene

Paralogs
for ALDH1A2 gene

Paralogs for ALDH1A2 gene

ALDH1L2²  ALDH1A1²  ENSG00000257767²  ALDH1B1²  ALDH7A1²  ALDH2²  ALDH16A1²  ALDH8A1²  

ALDH9A1²  ALDH1L1²  ALDH1A3²  

13 SIMAP similar genes for ALDH1A2 using alignment to 6 protein entries:     AL1A2_HUMAN (see all proteins):

RALDH2    ALDH1A1    ALDH1B1    ALDH2    ALDH1A3    DKFZp686G1675

ALDH1L1    ALDH1L2    ALDH9A1    ALDH8A1    ALDH5A1    ALDH6A1

ALDH7A1

ALDH1A2 for paralogs           About GeneDecksing

Genomic Variants
for ALDH1A2 gene

10/2483 NCBI SNPs in ALDH1A2 are shown (see all 2483)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 15 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs343070571,2	C,	--	35068218(-)	GTGACC/TGTACT	4	--	ds5001		6		NS WA	304
rs345798401,2	F	--	35068334(-)	TGCTG-/ATGATGGC	4	--	ds5001		5		NS	186
rs798411211,2	C,F,	--	35068664(+)	TCAGTA/GTGACC	4	--	ds5001		1		NA	120
rs788037741,2		--	35068710(+)	AGTACA/CCAATA	4	--	ut31		1		WA	118
rs358978841,2	C,	--	35068801(-)	CCTTTG/AGACTG	4	--	ut31		5		NS	190
rs356116001,2	C,F,H,	--	35068905(-)	GTGCCG/ATGAGC	4	--	ut31		13		NS NA WA	1198
rs1126287061,2		--	35069004(+)	TGGTAC/TGGTTA	4	--	ut31		1		CSA	2
rs345995711,2	C	--	35069108(-)	CCTAAA/GTGCAG	4	--	ut31		7		NS NA	194
rs360753271,2	C,	--	35069287(-)	AGGCCA/GTGGCC	4	--	ut31		6		NS NA	310
rs354371201,2	C,F,	--	35069313(-)	CACCCC/TATTCT	4	--	ut31		7		NS CSA WA	310

HapMap Linkage Disequilibrium report for ALDH1A2 (58245622 - 58495622 bp, first 250kb of ALDH1A2)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for ALDH1A2
     1 CNV: 102109
     5 Indels: 45350 41386 45349 40101 25534
Human Gene Mutation Database (HGMD): ALDH1A2

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ALDH1A2

DNA2.0 Custom Variant and Variant Library Synthesis for ALDH1A2

Disorders / Diseases
for ALDH1A2 gene

20/28 diseases for ALDH1A2

1 Novoseek disease relationship for ALDH1A2 gene    About this table

Publications
for ALDH1A2 gene

PubMed articles for ALDH1A2 gene, integrated from 9 sources (see all 88): (articles sorted by number of sources associating them with ALDH1A2)

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1. TAL1 and LIM-only proteins synergistically induce retinaldehyde dehydrogenase 2 expression in T-cell acute lymphoblastic leukemia by acting as cofactors for GATA3. (PubMed id 9819382)^{1, 2, 3} Ono Y.... Yoshie O. (1998)
2. Analysis of ALDH1A2, CYP26A1, CYP26B1, CRABP1, and CRABP2 in human neural tube defects suggests a possible association with alleles in ALDH1A2. (PubMed id 16237707)^{1, 4, 9} Deak K.L....Speer M.C. (2005)
3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
5. ALDH1A2 (RALDH2) genetic variation in human congenita l heart disease. (PubMed id 19886994)^{1, 9} Pavan M....Xavier-Neto J. (2009)
6. Cloning of a cDNA encoding an aldehyde dehydrogenase and its expression in Escherichia coli. Recognition of retinal as substrate. (PubMed id 8663198)^{1, 9} Wang X....Napoli J.L. (1996)
7. Positive association between ALDH1A2 and schizophreni a in the Chinese population. (PubMed id 19703508)^{1, 9} Wan C....He L. (2009)
8. Human basophils activated by mast cell-derived IL-3 express retinaldehyde dehydrogenase-II and produce the immunoregulatory mediator retinoic acid. (PubMed id 18495959)^{1, 9} Spiegl N....Dahinden C.A. (2008)
9. Retinoic acid synthesis controlled by Raldh2 is required early for limb bud initiation and then later as a proximodistal signal during apical ectodermal ridge formation. (PubMed id 15069081)^{7, 9} Mic F.A....Duester G. (2004)
10. Molecular identification of a major retinoic-acid-synthesizing enzyme, a retinaldehyde-specific dehydrogenase. (PubMed id 8797830)^{1, 9} Zhao D....Drager U.C. (1996)

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