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Aliases for ALDH1A1 Gene

Aliases for ALDH1A1 Gene

  • Aldehyde Dehydrogenase 1 Family Member A1 2 3 5
  • Aldehyde Dehydrogenase 1 Family, Member A1 2 3
  • Retinaldehyde Dehydrogenase 1 2 3
  • EC 4 63
  • RALDH 1 3 4
  • ALDH-E1 3 4
  • RALDH1 3 4
  • ALHDII 3 4
  • ALDH1 3 4
  • PUMB1 3 4
  • ALDC 3 4
  • Epididymis Secretory Sperm Binding Protein Li 53e 3
  • Aldehyde Dehydrogenase Family 1 Member A1 4
  • Aldehyde Dehydrogenase, Liver Cytosolic 3
  • Aldehyde Dehydrogenase 1, Soluble 3
  • Aldehyde Dehydrogenase, Cytosolic 4
  • Epididymis Luminal Protein 12 3
  • Acetaldehyde Dehydrogenase 1 3
  • Epididymis Luminal Protein 9 3
  • ALDH Class 1 3
  • HEL-S-53e 3
  • EC 1.2.1 63
  • ALDH11 3
  • HEL-9 3
  • HEL12 3

External Ids for ALDH1A1 Gene

Previous HGNC Symbols for ALDH1A1 Gene

  • PUMB1
  • ALDH1

Previous GeneCards Identifiers for ALDH1A1 Gene

  • GC09M066559
  • GC09M067372
  • GC09M069085
  • GC09M070972
  • GC09M072745
  • GC09M074705
  • GC09M075515
  • GC09M045338

Summaries for ALDH1A1 Gene

Entrez Gene Summary for ALDH1A1 Gene

  • The protein encoded by this gene belongs to the aldehyde dehydrogenase family. Aldehyde dehydrogenase is the next enzyme after alcohol dehydrogenase in the major pathway of alcohol metabolism. There are two major aldehyde dehydrogenase isozymes in the liver, cytosolic and mitochondrial, which are encoded by distinct genes, and can be distinguished by their electrophoretic mobility, kinetic properties, and subcellular localization. This gene encodes the cytosolic isozyme. Studies in mice show that through its role in retinol metabolism, this gene may also be involved in the regulation of the metabolic responses to high-fat diet. [provided by RefSeq, Mar 2011]

GeneCards Summary for ALDH1A1 Gene

ALDH1A1 (Aldehyde Dehydrogenase 1 Family Member A1) is a Protein Coding gene. Diseases associated with ALDH1A1 include Lung Adenoma and Erythroplakia. Among its related pathways are Fructose metabolism and Glycosaminoglycan metabolism. GO annotations related to this gene include oxidoreductase activity and acyl-CoA dehydrogenase activity. An important paralog of this gene is ALDH1A2.

UniProtKB/Swiss-Prot for ALDH1A1 Gene

  • Binds free retinal and cellular retinol-binding protein-bound retinal. Can convert/oxidize retinaldehyde to retinoic acid (By similarity).

Gene Wiki entry for ALDH1A1 Gene

PharmGKB "VIP" Summary for ALDH1A1 Gene

No data available for Tocris Summary , fRNAdb sequence ontologies and piRNA Summary for ALDH1A1 Gene

Genomics for ALDH1A1 Gene

Regulatory Elements for ALDH1A1 Gene

Enhancers for ALDH1A1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ALDH1A1 on UCSC Golden Path with GeneCards custom track

Genomic Location for ALDH1A1 Gene

72,900,662 bp from pter
73,080,442 bp from pter
179,781 bases
Minus strand

Genomic View for ALDH1A1 Gene

Genes around ALDH1A1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ALDH1A1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ALDH1A1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ALDH1A1 Gene

Proteins for ALDH1A1 Gene

  • Protein details for ALDH1A1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Retinal dehydrogenase 1
    Protein Accession:
    Secondary Accessions:
    • O00768
    • Q5SYR1

    Protein attributes for ALDH1A1 Gene

    501 amino acids
    Molecular mass:
    54862 Da
    Quaternary structure:
    • Homotetramer.

    Three dimensional structures from OCA and Proteopedia for ALDH1A1 Gene

neXtProt entry for ALDH1A1 Gene

Proteomics data for ALDH1A1 Gene at MOPED

Post-translational modifications for ALDH1A1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ALDH1A1 Gene

Antibody Products

  • R&D Systems Antibodies for ALDH1A1 (Aldehyde Dehydrogenase 1-A1/ALDH1A1)
  • Cell Signaling Technology (CST) Antibodies for ALDH1A1 (ALDH1A1)

Domains & Families for ALDH1A1 Gene

Gene Families for ALDH1A1 Gene

Protein Domains for ALDH1A1 Gene

Suggested Antigen Peptide Sequences for ALDH1A1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the aldehyde dehydrogenase family.
  • Belongs to the aldehyde dehydrogenase family.
genes like me logo Genes that share domains with ALDH1A1: view

Function for ALDH1A1 Gene

Molecular function for ALDH1A1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Retinal + NAD(+) + H(2)O = retinoate + NADH.
UniProtKB/Swiss-Prot Function:
Binds free retinal and cellular retinol-binding protein-bound retinal. Can convert/oxidize retinaldehyde to retinoic acid (By similarity).

Enzyme Numbers (IUBMB) for ALDH1A1 Gene

Gene Ontology (GO) - Molecular Function for ALDH1A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005497 androgen binding TAS 1709013
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with ALDH1A1: view
genes like me logo Genes that share phenotypes with ALDH1A1: view

Animal Models for ALDH1A1 Gene

MGI Knock Outs for ALDH1A1:

Animal Model Products

CRISPR Products

miRNA for ALDH1A1 Gene

miRTarBase miRNAs that target ALDH1A1

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ALDH1A1 Gene

Localization for ALDH1A1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ALDH1A1 Gene


Subcellular locations from

Jensen Localization Image for ALDH1A1 Gene COMPARTMENTS Subcellular localization image for ALDH1A1 gene
Compartment Confidence
cytosol 5
extracellular 5
cytoskeleton 2
mitochondrion 2
nucleus 2
chloroplast 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ALDH1A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 2987944
genes like me logo Genes that share ontologies with ALDH1A1: view

Pathways & Interactions for ALDH1A1 Gene

genes like me logo Genes that share pathways with ALDH1A1: view

Pathways by source for ALDH1A1 Gene

UniProtKB/Swiss-Prot P00352-AL1A1_HUMAN

  • Pathway: Cofactor metabolism; retinol metabolism.

Interacting Proteins for ALDH1A1 Gene

Gene Ontology (GO) - Biological Process for ALDH1A1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006805 xenobiotic metabolic process TAS --
GO:0008152 metabolic process IEA --
GO:0044281 small molecule metabolic process TAS --
GO:0061624 fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate TAS --
genes like me logo Genes that share ontologies with ALDH1A1: view

No data available for SIGNOR curated interactions for ALDH1A1 Gene

Drugs & Compounds for ALDH1A1 Gene

(18) Drugs for ALDH1A1 Gene - From: DrugBank, PharmGKB, ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cyclophosphamide Approved, Investigational Pharma Nitrogen mustard alkylating agent and prodrug. 2701
Tretinoin Approved, Investigational Nutra Full agonist, Agonist, Target 215
Vitamin A Approved Nutra Target 438
Carboplatin Approved Pharma Antitumor agent that forms platinum-DNA adducts., Platinum 1910
Thiotepa Approved Pharma 210

(21) Additional Compounds for ALDH1A1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 9-cis-Retinal
  • 9-cis-Retinaldehyde
  • 9-cis-Vitamin A aldehyde
  • cis-9-Retinal
  • Isoretinene A
9-cis-retinoic acid
  • 15-Apo-beta-caroten-15-oate
  • 15-Apo-beta-caroten-15-oic acid
  • 9-cis-Retinoate
  • 9-cis-Retinoic acid
  • 9-cis-Tretinoin
Hydrogen Ion
  • Hydrogen cation
  • Hydron
  • Proton
  • 3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-Nonatetraenal
  • All-E-Retinal
  • All-epsilon-Retinal
  • All-trans-Retinal
  • All-trans-Retinaldehyde
  • Dihydrogen oxide
  • Steam

(1) ApexBio Compounds for ALDH1A1 Gene

Compound Action Cas Number
Cyclophosphamide Nitrogen mustard alkylating agent and prodrug. 50-18-0
genes like me logo Genes that share compounds with ALDH1A1: view

Transcripts for ALDH1A1 Gene

Unigene Clusters for ALDH1A1 Gene

Aldehyde dehydrogenase 1 family, member A1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ALDH1A1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b
SP4: -

Relevant External Links for ALDH1A1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ALDH1A1 Gene

mRNA expression in normal human tissues for ALDH1A1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ALDH1A1 Gene

This gene is overexpressed in Liver (x4.7).

Protein differential expression in normal tissues from HIPED for ALDH1A1 Gene

This gene is overexpressed in Liver, secretome (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ALDH1A1 Gene

SOURCE GeneReport for Unigene cluster for ALDH1A1 Gene Hs.76392

genes like me logo Genes that share expression patterns with ALDH1A1: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for ALDH1A1 Gene

Orthologs for ALDH1A1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ALDH1A1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ALDH1A1 35
  • 90.15 (n)
  • 91.22 (a)
ALDH1A1 36
  • 91 (a)
(Canis familiaris)
Mammalia ALDH1A1 35
  • 88.42 (n)
  • 89.02 (a)
ALDH1A1 36
  • 87 (a)
(Mus musculus)
Mammalia Aldh1a1 35
  • 84.56 (n)
  • 87.03 (a)
Aldh1a1 16
Aldh1a1 36
  • 87 (a)
Aldh1a7 36
  • 84 (a)
(Pan troglodytes)
Mammalia ALDH1A1 35
  • 99.47 (n)
  • 100 (a)
ALDH1A1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Aldh1a1 35
  • 83.9 (n)
  • 86.43 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 73 (a)
-- 36
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia ALDH1A1 36
  • 85 (a)
(Gallus gallus)
Aves ALDH1A1 35
  • 79.39 (n)
  • 84.24 (a)
ALDH1A1 36
  • 82 (a)
(Anolis carolinensis)
Reptilia ALDH1A1 36
  • 82 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia aldh1a1 35
  • 74.38 (n)
  • 78.24 (a)
African clawed frog
(Xenopus laevis)
Amphibia LOC397729 35
(Danio rerio)
Actinopterygii aldh2.2 36
  • 62 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3752 37
  • 65 (a)
Aldh 36
  • 62 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADR417W 35
  • 54.07 (n)
  • 50.74 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ALD2 38
thale cress
(Arabidopsis thaliana)
eudicotyledons ALDH2C4 35
  • 57.55 (n)
  • 51.98 (a)
(Glycine max)
eudicotyledons Gma.8331 35
(Oryza sativa)
Liliopsida Os01g0591000 35
  • 56.04 (n)
  • 53.75 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8824 36
  • 67 (a)
Species with no ortholog for ALDH1A1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ALDH1A1 Gene

Gene Tree for ALDH1A1 (if available)
Gene Tree for ALDH1A1 (if available)

Paralogs for ALDH1A1 Gene

genes like me logo Genes that share paralogs with ALDH1A1: view

Variants for ALDH1A1 Gene

Sequence variations from dbSNP and Humsavar for ALDH1A1 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs8187929 - 72,925,588(-) TGCTC(A/T)TTTGG reference, missense
rs1049981 - 72,928,972(-) TCTGA(A/G)TGATT reference, missense
rs11554423 - 72,928,961(+) TAGCA(C/G)GCTGC reference, missense
rs647880 -- 72,944,902(-) ACTTG(A/G)AGTCC intron-variant
rs662728 -- 72,945,931(+) ATTTG(C/T)TTTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ALDH1A1 Gene

Variant ID Type Subtype PubMed ID
nsv893450 CNV Gain 21882294
nsv893451 CNV Gain 21882294
esv267946 CNV Insertion 20981092
esv272222 CNV Insertion 20981092
esv991190 CNV Insertion 20482838
nsv893452 CNV Gain 21882294

Variation tolerance for ALDH1A1 Gene

Residual Variation Intolerance Score: 33.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.06; 37.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ALDH1A1 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ALDH1A1 Gene

Disorders for ALDH1A1 Gene

MalaCards: The human disease database

(6) MalaCards diseases for ALDH1A1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
lung adenoma
  • adenoma of lung
  • erythroplasia
  • fibromyxosarcoma
alcohol dependence
  • alcohol dependence, protection against
breast cancer
  • breast cancer, invasive ductal
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ALDH1A1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ALDH1A1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ALDH1A1 Gene

Publications for ALDH1A1 Gene

  1. Association of ALDH1 promoter polymorphisms with alcohol-related phenotypes in Trinidad and Tobago. (PMID: 17286337) Moore S. … Ehlers C.L. (J Stud Alcohol Drugs 2007) 3 23 48 67
  2. Overexpression of aldehyde dehydrogenase 1A1 reduces oxidation-induced toxicity in SH-SY5Y neuroblastoma cells. (PMID: 19774675) Zhang M. … Ansari N.H. (J. Neurosci. Res. 2010) 3 23
  3. ALDH1A1 is a marker for malignant prostate stem cells and predictor of prostate cancer patients' outcome. (PMID: 20010854) Li T. … Jiang F. (Lab. Invest. 2010) 3 23
  4. Aldehyde dehydrogenase 1 A1-positive cell population is enriched in tumor-initiating cells and associated with progression of bladder cancer. (PMID: 20142235) Su Y. … Jiang F. (Cancer Epidemiol. Biomarkers Prev. 2010) 3 23
  5. In situ identification of putative cancer stem cells by multiplexing ALDH1, CD44, and cytokeratin identifies breast cancer patients with poor prognosis. (PMID: 20228222) Neumeister V. … Rimm D.L. (Am. J. Pathol. 2010) 3 23

Products for ALDH1A1 Gene

Sources for ALDH1A1 Gene