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ALDH1A1 Gene

protein-coding GIFtS: 65

GC09M074705

aldehyde dehydrogenase 1 family, member A1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: PUMB1, ALDH1)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
ALDC ^², ³
ALDH-E1 ^², ³
ALDH1 ^², ³
ALDH11 ^²
ALHDII ^³
EC 1.2.1.36 ^³
MGC2318 ^²
PUMB1 ^², ³
RALDH1 ^¹, ²
RalDH1 ^³

Descriptions
ALDH class 1 ^²
Aldehyde dehydrogenase family 1 member A1 ^³
Aldehyde dehydrogenase, cytosolic ^³
RALDH 1 ^³
acetaldehyde dehydrogenase 1 ^²
aldehyde dehydrogenase 1 family, member A1 ^²
aldehyde dehydrogenase 1, soluble ^²
aldehyde dehydrogenase 1A1 ^²
aldehyde dehydrogenase, liver cytosolic ^²
retinal dehydrogenase 1 ^²
retinaldehyde dehydrogenase 1 ^²

External Ids
HGNC: 402¹
Entrez Gene: 216²
UniProtKB: P00352³
Ensembl: ENSG00000165092⁷

Search outside databases for aliases for ALDH1A1 gene

Previous GC identifers: GC09M066559 GC09M067372 GC09M069085 GC09M070972 GC09M072745

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ALDH1A1:

This protein belongs to the aldehyde dehydrogenases family of proteins. Aldehyde dehydrogenase is

the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms

of this enzyme, cytosolic and mitochondrial, can be distinguished by their electrophoretic

mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major

isozymes, while approximately 50% of Orientals have only the cytosolic isozyme, missing the

mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals

than among Caucasians could be related to the absence of the mitochondrial isozyme. This gene

encodes a cytosolic isoform, which has a high affinity for aldehydes. [provided by RefSeq]

UniProtKB/Swiss-Prot: AL1A1_HUMAN, P00352

Function: Binds free retinal and cellular retinol-binding protein-bound retinal. Can

convert/oxidize retinaldehyde to retinoic acid (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ALDH1A1 gene

Entrez Gene cytogenetic band: 9q21.13 Ensembl cytogenetic band: 9q21.13 HGNC cytogenetic band: 9q21

ALDH1A1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09M074705: (about GC identifiers)

Start:	74,705,407 bp from pter
End:	74,757,792 bp from pter
Size:	52,386 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000009.10 NT_023935.17

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: AL1A1_HUMAN, P00352 (See protein sequence)

Recommended Name: Retinal dehydrogenase 1

Size: 501 amino acids; 54862 Da

Subunit: Homotetramer

Subcellular location: Cytoplasm

Secondary accessions: O00768

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_000680.2

ENSEMBL proteins:

ENSP00000366138 ENSP00000297785

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (ALDH1A1)
	Human Recombinant Proteins from Abnova (ALDH1A1)

OriGene Purified Recombinant Human Protein: ALDH1A1

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	18029348
GO:0005730	NOT nucleolus	IDA	18029348
GO:0005737	cytoplasm	TAS	2987944
GO:0005829	cytosol	EXP	224930

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Antibodies for ALDH1A1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for ALDH1A1
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (ALDH1A1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ALDH1A1)
	Novus Biologicals Antibodies for ALDH1A1

Assays for ALDH1A1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P00352

ProtoNet protein and cluster: P00352

1 Blocks protein family: IPB002086 Aldehyde dehydrogenase

UniProtKB/Swiss-Prot: AL1A1_HUMAN, P00352

Similarity: Belongs to the aldehyde dehydrogenase family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ALDH1A1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ALDH1A1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000689

Applied Biosystems Silencer® siRNAs for ALDH1A1

Sigma-Aldrich siRNA and siRNA Panels for ALDH1A1

Sigma-Aldrich shRNA for ALDH1A1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ALDH1A1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000689
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000689
untagged cDNA clone in CMV expression vector: NM_000689

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000689

UniProtKB/Swiss-Prot: AL1A1_HUMAN, P00352

Function: Binds free retinal and cellular retinol-binding protein-bound retinal. Can

convert/oxidize retinaldehyde to retinoic acid (By similarity)

Catalytic activity: Retinal + NAD(+) + H(2)O = retinoate + NADH

Enzyme Number (IUBMB): EC 1.2.1.36

6 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Aldh1a1):

endocrine/exocrine gland	lethality-prenatal/perinatal	liver/biliary system	normal	respiratory system
vision/eye

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001758	retinal dehydrogenase activity	IEA	--
GO:0004029	aldehyde dehydrogenase (NAD) activity	TAS	1709013
GO:0005099	Ras GTPase activator activity	TAS	1709013
GO:0005497	androgen binding	TAS	1709013
GO:0016491	oxidoreductase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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5/20 Sigma-Aldrich "Your Favorite Gene" Pathways for ALDH1A1 (Your Favorite Gene powered by Ingenuity) (see all 20 )

Xenobiotic Metabolism Signaling
Retinol Metabolism
Bile Acid Biosynthesis
Glycerolipid Metabolism
Tryptophan Metabolism

GeneDecks ALDH1A1 for the pathways selected above

About GeneDecksing

UniProtKB/Swiss-Prot: AL1A1_HUMAN, P00352

Pathway: Cofactor metabolism; retinol metabolism

Gene Network Central^TM Interacting Genes and Proteins Network for ALDH1A1

5/17 Interacting proteins for ALDH1A1 (ENSP00000297785³) via UniProtKB, MINT, and/or STRING (see all 17 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
BCMO1	ENSP00000258168³	STRING (score=.955)
RDH5	ENSP00000257895³	STRING (score=.952)
TLX1	ENSP00000359215³	STRING (score=.947)
ADHFE1	ENSP00000276576³	STRING (score=.938)
ADH1C	ENSP00000209668³	STRING (score=.921)

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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006081	cellular aldehyde metabolic process	TAS	1709013
GO:0055114	oxidation reduction	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Sigma-Aldrich Small Molecules for ALDH1A1:

Activator Crosslinker

Browse Tocris compounds for ALDH1A1
10/16 Novoseek chemical compound relationships for ALDH1A1 gene (see all 16 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
aldophosphamide	87.28	7	1610409 (3), 9714700 (2), 9322086 (1), 8654195 (1)
4-hydroxycyclophosphamide	83.12	12	9884322 (4), 18496131 (3)
retinaldehyde	82.84	16	17175089 (3), 1610409 (2), 10559215 (2), 11014218 (1) (see all 8)
4-hydroperoxycyclophosphamide	79.61	7	16614850 (2), 9551609 (1), 10773007 (1), 9714700 (1) (see all 5)
carboxyphosphamide	77.17	1	8654195 (1)
propionaldehyde	65.96	1	9701494 (1)
nad+	62.83	2	15924421 (1), 16878979 (1)
mafosfamide	56.26	2	8662658 (1), 8654195 (1)
chloroacetaldehyde	55.37	1	16878979 (1)
succinic semialdehyde	53.18	4	1610409 (2), 9490025 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ALDH1A1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ALDH1A1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000689

Sigma-Aldrich siRNA and siRNA Panels for ALDH1A1

Sigma-Aldrich shRNA for ALDH1A1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000689

REFSEQ mRNAs for ALDH1A1 gene:

NM_000689.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000689

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000689
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000689
                                 untagged cDNA clone in CMV expression vector: NM_000689

Additional cDNA sequence:

AB209821.1 AF003341.1 AK000118.1 AK026641.1 AK293176.1 AK302168.1 AY390731.1 BC001505.2

BT006921.1 CR601139.1 K03000.1 M26761.1

24/32 DOTS entries (see all 32 ):

DT.100885833 DT.97855829 DT.95145322 DT.91787600 DT.97855826 DT.121156154 DT.121156107 DT.100675525

DT.100039288 DT.100885835 DT.121156167 DT.100885830 DT.100885831 DT.121156121 DT.97855830 DT.100039289

DT.100885834 DT.121156085 DT.121156090 DT.121156092 DT.121156093 DT.121156102 DT.121156162 DT.121156165

24/893 AceView cDNA sequences (see all 893 ):

CB160652 AI800524 BM716589 F07279 BM705564 BM772990 BM503285 CD244688

BM856105 AA146679 AL713510 AA129143 BQ937897 CD245329 CB134326 NM_000689

BU507957 CR601139 AI912948 F03551 BM758430 AL544572 CB112556 CB161346

highest scoring ESTs for ALDH1A1:

AA082508 AA146679 AA305306 AA307608 AA314196 AA325083 AA366920 AF003341 AK000118 AK026641

Unigene Cluster for ALDH1A1:

Aldehyde dehydrogenase 1 family, member A1

Hs.76392 [show with all ESTs]

Unigene Representative Sequence: NM_000689

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for ALDH1A1

ExUns:	1	^	2	^	3	^	4	^	5a	·	5b	·	5c	^	6	^	7	^	8	^	9	^	10a	·	10b	^	11	^	12	^	13a	·	13b
SP1:
SP2:
SP3:
SP4:																													-

About this scheme

ECgene alternative splicing isoforms for ALDH1A1

2 Ensembl transcripts including schematic representations:

ENST00000376939 ENST00000297785

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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ALDH1A1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ALDH1A1

¹ / ² / ³

3 probe-sets matching ALDH1A1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
37015_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	K03000	0.80	1.00	0.91	1
212224_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000689	0.60	1.00	0.82	1
212224_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks ALDH1A1 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.76392
Expression variation in blood from EXPOLDB for ALDH1A1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for ALDH1A1 gene from 5/17 species (see all 17 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ALDH1A1¹	--	aldehyde dehydrogenase 1 family, member A1	88.42(n) 89.02(a)	476323 XM_533525.2 XP_533525.1
chimpanzee (Pan troglodytes)	ALDH1A1¹	--	aldehyde dehydrogenase 1 family, member A1	99.53(n) 100(a)	464529 XM_520075.2 XP_520075.2
cow (Bos taurus)	ALDH1A1¹	--	aldehyde dehydrogenase 1 family, member A1	90.15(n) 91.22(a)	281615 NM_174239.2 NP_776664.1
rat (Rattus norvegicus)	Aldh1a1¹	--	aldehyde dehydrogenase 1 family, member A1	83.9(n) 86.43(a)	24188 NM_022407.3 NP_071852.2
mouse (Mus musculus)	Aldh1a1^{1, 5}	19 (12.00 cM)⁵	aldehyde dehydrogenase family 1, subfamily A1^{1, 5}	84.56(n)¹ 87.03(a)¹	11668¹ NM_013467.3¹ NP_038495.2¹ BC035322⁵ BC044729⁵ (see all 13)

About this table Species with no ortholog for ALDH1A1

ENSEMBL Gene Tree for ALDH1A1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for ALDH1A1 gene

ALDH1A2² ALDH1A3²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/417 NCBI SNPs in ALDH1A1 are shown (see all 417 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 225)

AB	SNP ID	Valid	Chr 9 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs348485^1,2	A,C,F,H	74705274(+)	`TTACCT/CATTTG`	1	--	ng5¹		5	EU EA WA NS	580
	rs348445^1,2	A,C,F,H	74758623(-)	`CTAAAC/TATTAA`	1	--	ng3¹ tfbs³		18	EA NA NS MN WA	2784
	rs8188001^1,2	C,F,H	74705315(-)	`TAAAGG/TTACAT`	1	--	ng5¹		9	NS EU EA WA	1006
	rs17058197^1,2	C,F,H	74704953(+)	`AATTTC/TCTACC`	1	--	ng5¹		11	NA EU EA WA	978
	rs8188002^1,2	C,F,H	74705289(-)	`TAATCC/TACCTA`	1	--	ng5¹		5	NS EU EA WA	592
	rs4646548^1,2	C,F,H	74705366(-)	`TTGGTC/TACAGT`	1	--	ng5¹		23	NS EA NA EU WA	2254
	rs8187998^1,2	C,F,H	74705882(-)	`CTAATA/GTAGTA`	1	--	ut3¹		8	NS EU EA WA NA	686
	rs348484^1,2	C,F,H	74705145(+)	`CTACAA/GCACTT`	1	--	ng5¹		13	EU EA WA NS	1394
	rs8187929^1,2	C,F,H	74730324(-)	`TGCTCA/TTTTGG`	1	I/F	mis¹		9	NS EU EA WA	998
	rs8188000^1,2	C,F,H	74705489(-)	`ATGTCA/GTGTCT`	1	--	ut3¹ ese³		8	NS NA EU EA WA	680

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HapMap Linkage Disequilibrium images for ALDH1A1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 100640

10/11 Novoseek disease relationships for ALDH1A1 gene (see all 11 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
alcoholism	53.80	5	8160299 (1), 14506398 (1), 17286337 (1), 15967764 (1)
androgen insensitivity syndrome	48.63	2	9166904 (1), 8493922 (1)
cancer	16.05	5	12174908 (1), 19149630 (1), 19336570 (1), 19276181 (1)
parkinson disease	13.75	2	14678778 (2)
leiomyoma	13.04	1	17276435 (1)
metabolic disorder	12.79	1	9490025 (1)
cancer lung	9.58	7	19276181 (2), 17111384 (1)
tumors	9.05	21	11320670 (5), 17974998 (4), 10773007 (1), 12513786 (1) (see all 9)
breast cancer metastatic	8.62	8	11320670 (3), 9815579 (2)
breast cancer	0.00	4	11320670 (1), 19149630 (1)

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Human Gene Mutation Database: ALDH1A1
Genetic Association Database: ALDH1A1
Human Genome Epidemiology Navigator: ALDH1A1 (9 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/160 PubMed articles for ALDH1A1 gene (see all 160 ):

Evaluation of aldehyde dehydrogenase 1 promoter polymorphisms identified in human populations. (PubMed id 14506398)^{1, 3, 6} Spence J.P....Carr L.G. (2003)
Association of ALDH1 promoter polymorphisms with alcohol-related phenotypes in southwest California Indians. (PubMed id 15597079)^{1, 3, 6} Ehlers C.L....Carr L.G. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Biological role of human cytosolic aldehyde dehydrogenase 1: hormonal response, retinal oxidation and implication in testicular feminization. (PubMed id 8493914)^{3, 4} Yoshida A.... Yanagawa Y. (1993)
Cloning and expression of the full-length cDNAS encoding human liver class 1 and class 2 aldehyde dehydrogenase. (PubMed id 8214422)^{3, 4} Zheng C.F.... Weiner H. (1993)
The 56 kDa androgen binding protein is an aldehyde dehydrogenase. (PubMed id 1709013)^{2, 3} Pereira F....Wrogemann K. (1991)
Genomic structure of the human cytosolic aldehyde dehydrogenase gene. (PubMed id 2591967)^{3, 4} Hsu L.C.... Yoshida A. (1989)
Aldehyde dehydrogenase from human erythrocytes: structural relationship to the liver cytosolic isozyme. (PubMed id 2776714)^{3, 4} Agarwal D.P.... Hempel J. (1989)
Active site of human liver aldehyde dehydrogenase. (PubMed id 3676276)^{3, 4} Abriola D.P.... Pietruszko R. (1987)
Cloning of cDNAs for human aldehyde dehydrogenases 1 and 2. (PubMed id 2987944)^{3, 4} Hsu L.C....Yoshida A. (1985)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 216	HGNC: 402	AceView: ALDH1A1	Ensembl:ENSG00000165092	euGenes: HUgn216
ECgene: ALDH1A1	H-InvDB: ALDH1A1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for ALDH1A1	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/aldh1a1/

Licensable Technologies for ALDH1A1
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for ALDH1A1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ALDH1A1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
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	Predesigned and custom siRNAs for ALDH1A1		Antibodies for ALDH1A1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ALDH1A1		Small molecules for ALDH1A1
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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Antibodies for ALDH1A1

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ALDH1A1 Gene

protein-coding GIFtS: 65

Aliases &
Descriptions
for ALDH1A1

Summaries
for ALDH1A1

Genomic Location
for ALDH1A1

Proteins
for ALDH1A1

Protein Domains/
Families
for ALDH1A1

Gene Function
for ALDH1A1

Pathways & Interactions
for ALDH1A1

Drugs & Compounds
for ALDH1A1

Transcripts
for ALDH1A1

Expression
for ALDH1A1

Orthologs
for ALDH1A1

Paralogs
for ALDH1A1

SNPs/Variants
for ALDH1A1

Disorders & Mutations
for ALDH1A1

Medical News
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for ALDH1A1

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ALDH1A1 (Gene Symbol)
ALDC
ALDH-E1
ALDH1
ALDH11
ALHDII
EC 1.2.1.36
MGC2318
PUMB1
RALDH1
RalDH1
ALDH class 1
Aldehyde dehydrogenase family 1 member A1
Aldehyde dehydrogenase, cytosolic
RALDH 1
acetaldehyde dehydrogenase 1
aldehyde dehydrogenase 1 family, member A1
aldehyde dehydrogenase 1, soluble
aldehyde dehydrogenase 1A1
aldehyde dehydrogenase, liver cytosolic
retinal dehydrogenase 1
retinaldehyde dehydrogenase 1

ALDH1A1 Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor ALDH1A1

Summariesfor ALDH1A1

Genomic Locationfor ALDH1A1

Proteinsfor ALDH1A1

Protein Domains/Familiesfor ALDH1A1

Gene Functionfor ALDH1A1

Pathways & Interactionsfor ALDH1A1

Drugs & Compoundsfor ALDH1A1

Transcriptsfor ALDH1A1

Expression for ALDH1A1

Orthologsfor ALDH1A1

Paralogsfor ALDH1A1

SNPs/Variantsfor ALDH1A1

Disorders & Mutationsfor ALDH1A1

Medical Newsfor ALDH1A1

Publicationsfor ALDH1A1

Search for ALDH1A1

Genome Databases showing ALDH1A1

Other Databases showing ALDH1A1

Specialized Databases showing ALDH1A1

Licensable Technologiesfor ALDH1A1

Servicesfor ALDH1A1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ALDH1A1

Summaries
for ALDH1A1

Genomic Location
for ALDH1A1

Proteins
for ALDH1A1

Protein Domains/
Families
for ALDH1A1

Gene Function
for ALDH1A1

Pathways & Interactions
for ALDH1A1

Drugs & Compounds
for ALDH1A1

Transcripts
for ALDH1A1

Expression
for ALDH1A1

Orthologs
for ALDH1A1

Paralogs
for ALDH1A1

SNPs/Variants
for ALDH1A1

Disorders & Mutations
for ALDH1A1

Medical News
for ALDH1A1

Publications
for ALDH1A1

Licensable Technologies
for ALDH1A1

Services
for ALDH1A1