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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ALCAM Gene

protein-coding   GIFtS: 66
GCID: GC03P105085

activated leukocyte cell adhesion molecule

(Previous name: activated leucocyte cell adhesion molecule )
 Explore 33 diseases affiliated with
ALCAM via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ALCAM    

Aliases
for ALCAM gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Activated Leukocyte Cell Adhesion Molecule1 2 3
MEMD1 2 3
CD1661 2
CD166 Antigen2 3
Activated Leucocyte Cell Adhesion Molecule1

External Ids:    HGNC: 4001   Entrez Gene: 2142   Ensembl: ENSG000001700177   OMIM: 6016625   UniProtKB: Q137403   

Export aliases for ALCAM gene to outside databases

Previous GC identifers: GC03P101874 GC03P104601 GC03P106366 GC03P106406 GC03P106407 GC03P106568 GC03P102460


Summaries
for ALCAM gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ALCAM:
This gene encodes activated leukocyte cell adhesion molecule (ALCAM), also known as CD166 (cluster of differentiation
166), which is a member of a subfamily of immunoglobulin receptors with five immunoglobulin-like domains (VVC2C2C2) in
the extracellular domain. This protein binds to T-cell differentiation antigene CD6, and is implicated in the
processes of cell adhesion and migration. Multiple alternatively spliced transcript variants encoding different
isoforms have been found. (provided by RefSeq, Aug 2011)

UniProtKB/Swiss-Prot: CD166_HUMAN, Q13740
Function: Cell adhesion molecule that binds to CD6. Involved in neurite extension by neurons via heterophilic and
homophilic interactions. May play a role in the binding of T- and B-cells to activated leukocytes, as well as in
interactions between cells of the nervous system

Gene Wiki entry for ALCAM


Genomic Views
for ALCAM gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_005612.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ALCAM gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ALCAM promoter sequence
   Search SABiosciences Chromatin IP Primers for ALCAM

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ALCAM


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q13.1   Ensembl cytogenetic band:  3q13.11   HGNC cytogenetic band: 3q13.1

ALCAM Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ALCAM gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P105085:  view genomic region     (about GC identifiers)

Start:
 105,085,713 bp from pter      End:
 105,295,744 bp from pter
Size:
 210,032 bases      Orientation:
 plus strand

Proteins
for ALCAM gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CD166_HUMAN, Q13740 (See protein sequence)
Recommended Name: CD166 antigen precursor  
Size: 583 amino acids; 65102 Da
Subcellular location: Membrane; Single-pass type I membrane protein
1 PDB 3D structure from and Proteopedia for ALCAM:
1KJC (3D)    
Secondary accessions: B2RNS3 B4DTU0 O60892 Q1HGM8 Q1HGM9
Alternative splicing: 2 isoforms:  Q13740-1   Q13740-2   

Explore the universe of human proteins at neXtProt for ALCAM: NX_Q13740

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q13740

    • ALCAM Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_001230209.1  NP_001230210.1  NP_001230212.1  NP_001618.2  

    ENSEMBL proteins: 
     ENSP00000305988   ENSP00000419236   ENSP00000418213   ENSP00000418937   ENSP00000374577  
    Reactome Protein details: Q13740
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Novus Biologicals ALCAM Proteins
    Sino Biological Recombinant Protein for ALCAM
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ALCAM

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009897external side of plasma membrane IEA--
    GO:0016020membrane ----
    GO:0016021integral to membrane IEA--
    GO:0030424axon IEA--
    GO:0043025neuronal cell body IEA--


    ALCAM for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for ALCAM

    Protein Domains /
    Families
    for ALCAM gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ALCAM for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR007110 Ig-like_dom
     IPR013162 CD80_C2-set
     IPR003599 Ig_sub
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set

    Graphical View of Domain Structure for InterPro Entry Q13740

    ProtoNet protein and cluster: Q13740

    2 Blocks protein families:
    IPB003599 Immunoglobulin subtype
    IPB013162 CD80-like C2-set immunoglobulin


    UniProtKB/Swiss-Prot: CD166_HUMAN, Q13740
    Domain: The CD6 binding site is located in the N-terminal Ig-like domain
    Similarity: Contains 3 Ig-like C2-type (immunoglobulin-like) domains
    Similarity: Contains 2 Ig-like V-type (immunoglobulin-like) domains


    Function
    for ALCAM gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CD166_HUMAN, Q13740
    Function: Cell adhesion molecule that binds to CD6. Involved in neurite extension by neurons via heterophilic and
    homophilic interactions. May play a role in the binding of T- and B-cells to activated leukocytes, as well as in
    interactions between cells of the nervous system

         Genatlas biochemistry entry for ALCAM:
    activated leukocyte-cell adhesion molecule,CD6 ligand,homologous to rat KG-CAM,chicken neural adhesion molecule

    miRNA
    Products:            		miRTarBase miRNAs that target ALCAM:
    hsa-mir-192 (MIRT004163)

    OriGene 3'-UTR Clone: ALCAM
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ALCAM
    8/52 QIAGEN miScript miRNA Assays for microRNAs that regulate ALCAM (see all 52):
    hsa-miR-411* hsa-miR-142-5p hsa-miR-323-3p hsa-miR-379* hsa-miR-4328 hsa-miR-449a hsa-miR-192 hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmid: ALCAM 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ALCAM (see all 7)
    OriGene shRNA RFP: ALCAM
    OriGene siRNA: ALCAM
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ALCAM

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ALCAM

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ALCAM (see all 3)
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    GenScript: all cDNA clones in your preferred vector: ALCAM (NM_001627)
    Sino Biological Human cDNA Clone for ALCAM
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ALCAM
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALCAM 

    Cell Line
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    Search LifeMap BioReagents cell lines for ALCAM

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALCAM

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding TAS7760007
    GO:0005515protein binding ----


    ALCAM for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for ALCAM:
     Increased gamma-H2AX phosphory  Upregulation of Wnt/beta-caten 

    Animal Models:
         2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Alcam):
     nervous system  vision/eye 

    ALCAM for phenotypes           About GeneDecksing


    Pathways & Interactions
    for ALCAM gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Axon guidance
    		Axon guidance1.00
    		L1CAM interactions0.39
    		Developmental Biology0.69
    2Cell adhesion molecules (CAMs)
    		Cell adhesion molecules (CAMs)1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    3        Reactome Pathways for ALCAM
        L1CAM interactions
    Developmental Biology
    Axon guidance


    1         Kegg Pathway  (Kegg details for ALCAM):
        Cell adhesion molecules (CAMs)


    ALCAM for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ALCAM

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/9 Interacting proteins for ALCAM (Q137403 ENSP000003059884) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CD6P302033, ENSP000003232804I2D: score=3 STRING: ENSP00000323280
    RELAQ042063, ENSP000003842734I2D: score=1 STRING: ENSP00000384273
    EGFRP005333, ENSP000002754934I2D: score=3 STRING: ENSP00000275493
    L1CAMENSP000003590744STRING: ENSP00000359074
    PIGQENSP000000262184STRING: ENSP00000026218
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion IEA--
    GO:0007165signal transduction TAS7760007
    GO:0007411axon guidance TAS--
    GO:0008045motor neuron axon guidance IEA--


    ALCAM for ontologies           About GeneDecksing



    Drugs & Compounds
    for ALCAM gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ALCAM for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ALCAM
    3 Novoseek chemical compound relationships for ALCAM gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    estrogen 7.7 6 18810438 (2), 16810131 (1), 16865058 (1), 18172759 (1)
    progesterone 0 1 16810131 (1)
    tyrosine 0 1 15618003 (1)

    Search CenterWatch for drugs/clinical trials and news about ALCAM / CD166 

    Transcripts
    for ALCAM gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ALCAM gene (4 alternative transcripts): 
    NM_001243280.1  NM_001243281.1  NM_001243283.1  NM_001627.3  

    Unigene Clusters for ALCAM:

    Activated leukocyte cell adhesion molecule
    Hs.591293  [show with all ESTs], Hs.740441  [show with all ESTs]
    Unigene Representative Sequences: NM_001627, AB074167
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000306107(uc003dvw.2 uc003dvx.3 uc003dvy.3 uc010hpp.3 uc003dvz.3)
    ENST00000470756(uc003dvv.3) ENST00000472644 ENST00000481337(uc011bhh.1)
    ENST00000486979 ENST00000460954 ENST00000465413 ENST00000491388 ENST00000489178
    ENST00000389927

    miRNA
    Products:             		 OriGene 3'-UTR Clone: ALCAM
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ALCAM
    8/52 QIAGEN miScript miRNA Assays for microRNAs that regulate ALCAM (see all 52):
    hsa-miR-411* hsa-miR-142-5p hsa-miR-323-3p hsa-miR-379* hsa-miR-4328 hsa-miR-449a hsa-miR-192 hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmid: ALCAM 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ALCAM (see all 7)
    OriGene shRNA RFP: ALCAM
    OriGene siRNA: ALCAM
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ALCAM
    Clone
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: ALCAM (NM_001627)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ALCAM
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALCAM 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ALCAM
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ALCAM
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ALCAM

    Additional cDNA sequence: AB074167.1 

    19 DOTS entries:

    DT.451628  DT.95170077  DT.40107844  DT.99975109  DT.91752875  DT.100043266  DT.99990630  DT.100810542 
    DT.100822887  DT.91752878  DT.92041066  DT.97823455  DT.100045293  DT.435942  DT.91643802  DT.99965331 
    DT.80101947  DT.91752865  DT.91752876 

    24/403 AceView cDNA sequences (see all 403):

    AI332387 CB145726 BX114181 AU118527 AI050952 W51882 BU629686 AL041869 
    BP336131 CA425631 BM724480 BU178192 BM980200 BU952023 H99250 AA777157 
    AI358995 BP341724 D57901 BC041127 AA156842 BG674686 BM994993 AA280417 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for ALCAM (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b
    SP1:                          -                                   -                                   -                 -                     
    SP2:                                                  -     -     -                                   -                 -                     
    SP3:                                                                                                  -                 -                     
    SP4:                                                                                                  -     -           -                     
    SP5:                                                                                                                                          


    ECgene alternative splicing isoforms for ALCAM

    Expression
    for ALCAM gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ALCAM expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CACGAAGATG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ALCAM expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/18 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 18) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LiverHepatic MesenchymeMesothelial CellsLiver
    BoneCervical VertebraeEndochondral PreosteoblastsBone
    BoneLumbar VertebraeEndochondral PreosteoblastsBone
    BoneSacral VertebraeEndochondral PreosteoblastsBone
    BoneThoracic RibEndochondral PreosteoblastsBone
    BoneThoracic VertebraeEndochondral PreosteoblastsBone
    LiverMesoblastic Supporting StromaLiver FibroblastsLiver
    LiverMesoblastic Supporting StromaPre-stellate CellsLiver
    LiverMesoblastic Supporting StromaSubmesothelial CellsLiver
    Extraembryonic MesodermExtraembryonic Capillary PlexusExtraembryonic AngioblastsEndothelium
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 9 LifeMap Cells 
    NameCategory
    Bone marrow-derived mesenchymal stem cells (Lonza) (Adult Stem / Progenitor Cell)Bone
    Human bone marrow-derived mesenchymal stem cells (Adult Stem / Progenitor Cell)Bone
    AS034 (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Mesenchymal-like stem cells (Chondrogenic differe...)
    Pelleted cells (Chondrogenic differe...)
    Endoderm progenitor-like cells (Generation and expan...)
    CD73-positive cells (Generation of skelet...)
    Connective tissue progenitor cells (Generation of connec...)
    Midbrain dopaminergic-like neurons (Generation of midbra...)

    See ALCAM Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ALCAM

    SOURCE GeneReport for Unigene clusters: Hs.591293 Hs.740441

    UniProtKB/Swiss-Prot: CD166_HUMAN, Q13740
    Tissue specificity: Spleen, placenta, liver, and weakly in liver. Expressed by activated T-cells, B-cells, monocytes
    and thymic epithelial cells. Expressed by neurons in the brain. Restricted expression in tumor cell lines.
    Preferentially expressed in highly metastasizing melanoma cell lines

        SABiosciences Expression via Pathway-Focused PCR Arrays including ALCAM: 
              Cell Surface Markers in human mouse rat
              Mesenchymal Stem Cell in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ALCAM
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALCAM

    Orthologs
    for ALCAM gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for ALCAM gene from 4/12 species (see all 12)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves ALCAM1 activated leukocyte cell adhesion molecule 76.87(n)
    74.96(a)    		   396092  NM_205179.1  NP_990510.1 
    lizard
    (Anolis carolinensis)    		 Reptilia ALCAM6
    		 --
    		 70(a)
    		 1 ↔ 1
    		 3(170822661-170889643)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.16432 Xenopus laevis transcribed sequence with weak similarity more 77.93(n)    BU907815.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii alcama6
    alcamb6
    		 activated leukocyte cell adhesion molecule b
    		 38(a)
    37(a)
    		 1 ↔ many
    1 ↔ many
    		 10(29413530-29443326)
    15(18800100-18840629)


    ENSEMBL Gene Tree for ALCAM (if available)
    TreeFam Gene Tree for ALCAM (if available) 

    Paralogs
    for ALCAM gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ALCAM gene
    BCAM2  MCAM2  AGER2  
    2 SIMAP similar genes for ALCAM using alignment to 5 protein entries:     CD166_HUMAN (see all proteins):
    AGER    IGLV3-27

    ALCAM for paralogs           About GeneDecksing



    Genomic Variants
    for ALCAM gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3278 NCBI SNPs in ALCAM are shown (see all 3278)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 3 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs762458951,2
    		--102459050(+) AAAAAA/TTATGG 4 -- us2k11Minor allele frequency- T:0.01NA 120
    rs40801831,2
    		C--102459570(+) CTTTAG/TAAATT 4 -- us2k10--------
    rs760040221,2
    		F,--102459590(+) GCCTGT/CCCATC 4 -- us2k11Minor allele frequency- C:0.03NA 120
    rs76474261,2
    		C,--102459840(+) CGACTC/GACGTA 4 -- us2k13Minor allele frequency- G:0.12CSA WA EA 239
    rs76475311,2
    		C,--102459961(+) GGTTGC/ACCCTG 4 -- us2k14Minor allele frequency- A:0.08CSA WA NA EA 359
    rs98665611,2
    		C,F,--102460248(+) GGAAGC/GCAGAG 4 -- us2k16Minor allele frequency- G:0.09NA WA EA 248
    rs794389351,2
    		F,--102460320(+) CGCGCG/CGCTCC 4 -- us2k11Minor allele frequency- C:0.03NA 120
    rs1141997961,2
    		C,F,--102460746(+) TTATTA/GTCATT 4 -- ut511Minor allele frequency- G:0.04WA 118
    rs731774591,2
    		C,--102461598(+) CTTTAA/GTCACC 4 -- int14Minor allele frequency- G:0.12CSA WA NA EA 359
    rs1119961881,2
    		--102462287(+) GTTTGT/AAAGCC 4 -- int11Minor allele frequency- A:0.50CSA 2

    HapMap Linkage Disequilibrium report for ALCAM (105085713 - 105295744 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for ALCAM
         1 CNV: 4348
    Human Gene Mutation Database (HGMD): ALCAM

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ALCAM
    DNA2.0 Custom Variant and Variant Library Synthesis for ALCAM

    Disorders / Diseases
    for ALCAM gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ALCAM for disorders           About GeneDecksing

    OMIM gene information: 601662    OMIM disorders: --

    20/33 diseases for ALCAM (see all 33):    About MalaCards
    estrogen-receptor negative breast cancer    appendix adenocarcinoma    squamous cell carcinoma    oral squamous cell carcinoma
    esophageal squamous cell carcinoma    rheumatoid arthritis    intrahepatic cholangiocarcinoma    neuroendocrine tumor
    renal cell carcinoma    hodgkin's lymphoma    prostate cancer    breast cancer
    prostate cancer, progression of    melanoma metastasis    breast carcinoma    carcinoma
    cholangiocarcinoma    melanoma    arthritis    oral cancer

    10/12 Novoseek disease relationships for ALCAM gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    melanoma 41.3 17 10702391 (4), 15140234 (2), 9502422 (2), 18279810 (1) (see all 6)
    metastasis 35.1 31 18202807 (5), 20364042 (5), 15318930 (4), 15140234 (1) (see all 9)
    primary tumor 33.3 7 15140234 (2), 20208136 (1), 20364042 (1), 10702391 (1) (see all 6)
    tumors 29.6 65 16818742 (5), 16810131 (4), 15318930 (4), 20208136 (2) (see all 14)
    breast cancer 24.6 29 15318930 (6), 18202807 (4), 16810131 (4), 16484444 (3) (see all 9)
    cancer 23.1 14 19157844 (2), 20180536 (1), 18202807 (1), 20148583 (1) (see all 8)
    breast carcinoma 20.7 1 16484444 (1)
    prostate cancer 14.9 10 12481253 (3), 18279810 (1), 15509676 (1), 10673383 (1)
    colon cancer 7.15 2 16484444 (1), 15509676 (1)
    inflammation 0 1 9870879 (1)

    Human Genome Epidemiology (HuGE) Navigator: ALCAM (6 documents)

    Export disorders for ALCAM gene to outside databases

    Publications
    for ALCAM gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ALCAM gene, integrated from 9 sources (see all 154):
    (articles sorted by number of sources associating them with ALCAM)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, mapping, and characterization of activated leukocyte-cell adhesion molecule (ALCAM), a CD6 ligand. (PubMed id 7760007)1, 2, 3, 9 Bowen M.A....Aruffo A. (1995)
    2. MEMD, a new cell adhesion molecule in metastasizing human melanoma cell lines, is identical to ALCAM (activated leukocyte cell adhesion molecule). (PubMed id 9502422)1, 2, 9 Degen W.G.... Swart G.W. (1998)
    3. Recognition of diverse proteins by members of the immunoglobulin superfamily: delineation of the receptor binding site in the human CD6 ligand ALCAM. (PubMed id 8823162)1, 2, 9 Skonier J.E.... Bajorath J. (1996)
    4. Molecular model of the N-terminal receptor-binding domain of the human CD6 ligand ALCAM. (PubMed id 8520490)1, 2, 9 Bajorath J.... Aruffo A. (1995)
    5. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (2005)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. (PubMed id 12754519)1, 2 Zhang H.... Aebersold R. (2003)
    8. Expression levels of Activated Leukocyte Cell Adhesio n Molecule (ALCAM/CD166) in primary breast carcinoma and distant breast cancer metastases. (PubMed id 20364042)1, 9 Ihnen M....Kilic E. (2010)
    9. Molecular isolation and characterization of a soluble isoform of activated leukocyte cell adhesion molecule that modulates endothelial cell function. (PubMed id 15496415)1, 9 Ikeda K. and Quertermous T. (2004)
    10. Different subcellular localization of ALCAM molecules in neuroblastoma: Association with relapse. (PubMed id 20208136)1, 9 Corrias M.V....Fabbi M. (2010)

    External Searches for ALCAM gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ALCAM gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 214 HGNC: 400 AceView: ALCAM Ensembl:ENSG00000170017 euGenes: HUgn214
    ECgene: ALCAM Kegg: 214 H-InvDB: ALCAM

    Other Databases showing ALCAM gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ALCAM gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ALCAM Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ALCAM Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for ALCAM gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ALCAM gene:
    Search GeneIP for patents involving ALCAM

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    About This Section

     
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