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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ALCAM Gene

protein-coding   GIFtS: 66
GCID: GC03P105085

Activated Leukocyte Cell Adhesion Molecule

(Previous name: activated leucocyte cell adhesion molecule)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Activated Leukocyte Cell Adhesion Molecule1 2 3
MEMD2 3
CD166 Antigen2 3
Activated Leucocyte Cell Adhesion Molecule1
CD1662

External Ids:    HGNC: 4001   Entrez Gene: 2142   Ensembl: ENSG000001700177   OMIM: 6016625   UniProtKB: Q137403   

Export aliases for ALCAM gene to outside databases

Previous GC identifers: GC03P101874 GC03P104601 GC03P106366 GC03P106406 GC03P106407 GC03P106568 GC03P102460


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ALCAM Gene:
This gene encodes activated leukocyte cell adhesion molecule (ALCAM), also known as CD166 (cluster of
differentiation 166), which is a member of a subfamily of immunoglobulin receptors with five immunoglobulin-like
domains (VVC2C2C2) in the extracellular domain. This protein binds to T-cell differentiation antigene CD6, and is
implicated in the processes of cell adhesion and migration. Multiple alternatively spliced transcript variants
encoding different isoforms have been found. (provided by RefSeq, Aug 2011)

GeneCards Summary for ALCAM Gene: 
ALCAM (activated leukocyte cell adhesion molecule) is a protein-coding gene. Diseases associated with ALCAM include appendix adenocarcinoma, and estrogen-receptor negative breast cancer, and among its related super-pathways are Axon guidance. GO annotations related to this gene include receptor binding. An important paralog of this gene is BCAM.

UniProtKB/Swiss-Prot: CD166_HUMAN, Q13740
Function: Cell adhesion molecule that binds to CD6. Involved in neurite extension by neurons via heterophilic and
homophilic interactions. May play a role in the binding of T- and B-cells to activated leukocytes, as well as in
interactions between cells of the nervous system

Gene Wiki entry for ALCAM Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.2  NT_005612.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ALCAM gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidALCAM promoter sequence
   Search SABiosciences Chromatin IP Primers for ALCAM

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ALCAM


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q13.1   Ensembl cytogenetic band:  3q13.11   HGNC cytogenetic band: 3q13.1

ALCAM Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ALCAM gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P105085:  view genomic region     (about GC identifiers)

Start:
105,085,713 bp from pter      End:
105,295,744 bp from pter
Size:
210,032 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CD166_HUMAN, Q13740 (See protein sequence)
Recommended Name: CD166 antigen precursor  
Size: 583 amino acids; 65102 Da
Subcellular location: Membrane; Single-pass type I membrane protein
1 PDB 3D structure from and Proteopedia for ALCAM:
1KJC (3D)    
Secondary accessions: B2RNS3 B4DTU0 O60892 Q1HGM8 Q1HGM9
Alternative splicing: 2 isoforms:  Q13740-1   Q13740-2   

Explore the universe of human proteins at neXtProt for ALCAM: NX_Q13740

Explore proteomics data for ALCAM at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q13740

  • ALCAM Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ALCAM Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001230209.1  NP_001230210.1  NP_001230212.1  NP_001618.2  

    ENSEMBL proteins: 
     ENSP00000305988   ENSP00000419236   ENSP00000418213   ENSP00000418937   ENSP00000374577  
    Reactome Protein details: Q13740
    Human Recombinant Protein Products for ALCAM: 
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    Novus Biologicals ALCAM Proteins
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    Cloud-Clone Corp. Proteins for ALCAM 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009897external side of plasma membrane IEA--
    GO:0016020membrane ----
    GO:0016021integral to membrane IEA--
    GO:0030424axon IEA--
    GO:0043025neuronal cell body IEA--

    ALCAM for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for ALCAM


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    C2SET: Immunoglobulin superfamily / C2-set domain containing
    CD: CD molecules
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing
    VSET: Immunoglobulin superfamily / V-set domain containing

    5 InterPro protein domains:
     IPR007110 Ig-like_dom
     IPR013162 CD80_C2-set
     IPR003599 Ig_sub
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set

    Graphical View of Domain Structure for InterPro Entry Q13740

    ProtoNet protein and cluster: Q13740

    2 Blocks protein domains:
    IPB003599 Immunoglobulin subtype
    IPB013162 CD80-like C2-set immunoglobulin


    UniProtKB/Swiss-Prot: CD166_HUMAN, Q13740
    Domain: The CD6 binding site is located in the N-terminal Ig-like domain
    Similarity: Contains 3 Ig-like C2-type (immunoglobulin-like) domains
    Similarity: Contains 2 Ig-like V-type (immunoglobulin-like) domains


    ALCAM for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CD166_HUMAN, Q13740
    Function: Cell adhesion molecule that binds to CD6. Involved in neurite extension by neurons via heterophilic and
    homophilic interactions. May play a role in the binding of T- and B-cells to activated leukocytes, as well as in
    interactions between cells of the nervous system

         Genatlas biochemistry entry for ALCAM:
    activated leukocyte-cell adhesion molecule,CD6 ligand,homologous to rat KG-CAM,chicken neural adhesion molecule

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding TAS7760007
    GO:0005515protein binding ----
         
    ALCAM for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ALCAM:
     Increased gamma-H2AX phosphory  Upregulation of Wnt/beta-caten 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Alcam):
     nervous system  vision/eye 

    ALCAM for phenotypes           About GeneDecksing

    Animal Models:
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    hsa-miR-411* hsa-miR-142-5p hsa-miR-323-3p hsa-miR-379* hsa-miR-4328 hsa-miR-449a hsa-miR-192 hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmidALCAM 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ALCAM About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Axon guidance
    Axon guidance0.69
    L1CAM interactions0.39
    Developmental Biology0.69
    2Cell adhesion molecules (CAMs)
    Cell adhesion molecules (CAMs)

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    3        Reactome Pathways for ALCAM
        L1CAM interactions
    Developmental Biology
    Axon guidance


    1         Kegg Pathway  (Kegg details for ALCAM):
        Cell adhesion molecules (CAMs)


    ALCAM for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ALCAM

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/9 Interacting proteins for ALCAM (Q137403 ENSP000003059884) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CD6P302033, ENSP000003232804I2D: score=3 STRING: ENSP00000323280
    RELAQ042063, ENSP000003842734I2D: score=1 STRING: ENSP00000384273
    EGFRP005333, ENSP000002754934I2D: score=3 STRING: ENSP00000275493
    L1CAMENSP000003590744STRING: ENSP00000359074
    PIGQENSP000000262184STRING: ENSP00000026218
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion IEA--
    GO:0007165signal transduction TAS7760007
    GO:0007411axon guidance TAS--
    GO:0008045motor neuron axon guidance IEA--

    ALCAM for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ALCAM for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ALCAM (CD166)

    3 Novoseek inferred chemical compound relationships for ALCAM gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    estrogen 7.7 6 18810438 (2), 16810131 (1), 16865058 (1), 18172759 (1)
    progesterone 0 1 16810131 (1)
    tyrosine 0 1 15618003 (1)

    Search CenterWatch for drugs/clinical trials and news about ALCAM / CD166

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ALCAM gene (4 alternative transcripts): 
    NM_001243280.1  NM_001243281.1  NM_001243283.1  NM_001627.3  

    Unigene Clusters for ALCAM:

    Activated leukocyte cell adhesion molecule
    Hs.591293  [show with all ESTs], Hs.740441  [show with all ESTs]
    Unigene Representative Sequences: NM_001627, AB074167
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000306107(uc003dvw.2 uc003dvx.3 uc003dvy.3 uc010hpp.3 uc003dvz.3)
    ENST00000470756(uc003dvv.3) ENST00000472644 ENST00000481337(uc011bhh.1)
    ENST00000486979 ENST00000460954 ENST00000465413 ENST00000491388 ENST00000489178
    ENST00000389927
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    8/52 QIAGEN miScript miRNA Assays for microRNAs that regulate ALCAM (see all 52):
    hsa-miR-411* hsa-miR-142-5p hsa-miR-323-3p hsa-miR-379* hsa-miR-4328 hsa-miR-449a hsa-miR-192 hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmidALCAM 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AB074167.1 AF086091.1 

    19 DOTS entries:

    DT.451628  DT.95170077  DT.40107844  DT.99975109  DT.91752875  DT.100043266  DT.99990630  DT.100810542 
    DT.100822887  DT.91752878  DT.92041066  DT.97823455  DT.100045293  DT.435942  DT.91643802  DT.99965331 
    DT.80101947  DT.91752865  DT.91752876 

    24/403 AceView cDNA sequences (see all 403):

    N26375 BE043005 AI218908 BU741679 AI753586 BM757832 AW242676 W73410 
    BX951955 D57901 AI435550 F06946 BQ019458 BQ775535 W51882 AA304516 
    Z40035 AL703362 CB117828 BM971365 AW130015 CB145726 AL041869 CA425631 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for ALCAM (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b
    SP1:                          -                                   -                                   -                 -                     
    SP2:                                                  -     -     -                                   -                 -                     
    SP3:                                                                                                  -                 -                     
    SP4:                                                                                                  -     -           -                     
    SP5:                                                                                                                                          


    ECgene alternative splicing isoforms for ALCAM

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ALCAM expression in normal human tissues (normalized intensities)      ALCAM embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACGAAGATG
    ALCAM Expression
    About this image


    ALCAM expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/36 selected tissues (see all 36) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 16 entries
             Mesenchymal Stem Cells Zeugopod Periosteum
             Bone marrow-derived mesenchymal stem cells
     
     Mesenchymal Stem Cells
             Placenta-derived mesenchymal stem cells
     
     Liver (Hepatobiliary System)    fully expand to see all 6 entries
             Mesothelial Cells Hepatic Mesenchyme
             liver ; bile duct cells   
     
     Neural Tube (Nervous System)    fully expand to see all 6 entries
             Metencephalon
     
     Lung (Respiratory System)    fully expand to see all 5 entries
             Trachea
             lung ; pneumocytes   
             trachea   

    See ALCAM Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ALCAM

    SOURCE GeneReport for Unigene clusters: Hs.591293 Hs.740441

    UniProtKB/Swiss-Prot: CD166_HUMAN, Q13740
    Tissue specificity: Spleen, placenta, liver, and weakly in liver. Expressed by activated T-cells, B-cells,
    monocytes and thymic epithelial cells. Expressed by neurons in the brain. Restricted expression in tumor cell
    lines. Preferentially expressed in highly metastasizing melanoma cell lines

        SABiosciences Expression via Pathway-Focused PCR Arrays including ALCAM: 
              Cell Surface Markers in human mouse rat
              Mesenchymal Stem Cell in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALCAM

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ALCAM gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Alcam1 , 5 activated leukocyte cell adhesion molecule1, 5 89.25(n)1
    92.97(a)1
      16 (32.88 cM)5
    116581  NM_009655.21  NP_033785.11 
     522489965 
    chicken
    (Gallus gallus)
    Aves ALCAM1 activated leukocyte cell adhesion molecule 76.87(n)
    74.96(a)
      396092  NM_205179.1  NP_990510.1 
    lizard
    (Anolis carolinensis)
    Reptilia ALCAM6
    activated leukocyte cell adhesion molecule
    73(a)
    1 ↔ 1
    3(170815551-170889257)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.16432 Xenopus laevis transcribed sequence with weak similarity more 77.93(n)    BU907815.1 
    zebrafish
    (Danio rerio)
    Actinopterygii alcamb6
    alcama6
    activated leukocyte cell adhesion molecule a
    37(a)
    37(a)
    1 ↔ many
    1 ↔ many
    15(18800100-18840629)
    10(29413530-29443326)


    ENSEMBL Gene Tree for ALCAM (if available)
    TreeFam Gene Tree for ALCAM (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ALCAM gene
    BCAM2  MCAM2  
    2 SIMAP similar genes for ALCAM using alignment to 5 protein entries:     CD166_HUMAN (see all proteins):
    AGER    IGLV3-27

    ALCAM for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3830 SNPs in ALCAM are shown (see all 3830)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2021080891,2
    C--102483037(+) TTTTTC/TCTAAA 4 -- int10--------
    rs766671591,2
    C--102487536(+) GTTTT-/CCACAT 4 -- int10--------
    rs2001400351,2
    --102498320(+) AAAAA-/TAAAAC 4 -- int10--------
    rs1419009191,2
    C--102498942(+) AAAAA-/GACAAAGA 4 -- int10--------
    rs67750361,2
    C,A--102498943(+) aaaagA/C/Gcaaag 4 -- int1 trp30--------
    rs754072111,2
    C--102502970(+) GTGAC-/ATATATA 4 -- int10--------
    rs1507933421,2
    C--102542114(+) CCATT-/A/AA  
            
    TAAAA
    4 -- int10--------
    rs759999031,2
    C--102544798(+) CAAAG-/AAGT  
            
    AAGTA
    4 -- int10--------
    rs1396290001,2
    C--102544799(+) CAAAG-/AAGT  
            
    AAGTA
    4 -- int10--------
    rs789063001,2
    --102562892(+) GCGGGG/TTTTTT 4 -- int11Minor allele frequency- T:0.50CSA 2

    HapMap Linkage Disequilibrium report for ALCAM (105085713 - 105295744 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for ALCAM:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv829651CNV Loss17160897
    nsv509844CNV Loss20534489
    nsv877304CNV Gain21882294
    nsv525071CNV Gain19592680
    nsv829650CNV Gain17160897
    nsv460811CNV Gain19166990


    Human Gene Mutation Database (HGMD): ALCAM
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ALCAM
    DNA2.0 Custom Variant and Variant Library Synthesis for ALCAM

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601662    OMIM disorders: --

    20/32 diseases for ALCAM (see all 32):    About MalaCards
    appendix adenocarcinoma    estrogen-receptor negative breast cancer    neuroendocrine tumor    prostate cancer, progression of
    malignant mesothelioma    oral cancer    prostate cancer    melanoma
    squamous cell carcinoma    intrahepatic cholangiocarcinoma    breast cancer    esophageal squamous cell carcinoma
    cholangiocarcinoma    oral squamous cell carcinoma    esophageal cancer    rheumatoid arthritis
    prostatitis    arthritis    type 1 diabetes    hodgkin's lymphoma


    ALCAM for disorders           About GeneDecksing

    10/12 Novoseek inferred disease relationships for ALCAM gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    melanoma 41.3 17 10702391 (4), 15140234 (2), 9502422 (2), 18279810 (1) (see all 6)
    metastasis 35.1 31 18202807 (5), 20364042 (5), 15318930 (4), 15140234 (1) (see all 9)
    primary tumor 33.3 7 15140234 (2), 20208136 (1), 20364042 (1), 10702391 (1) (see all 6)
    tumors 29.6 65 16818742 (5), 16810131 (4), 15318930 (4), 20208136 (2) (see all 14)
    breast cancer 24.6 29 15318930 (6), 18202807 (4), 16810131 (4), 16484444 (3) (see all 9)
    cancer 23.1 14 19157844 (2), 20180536 (1), 18202807 (1), 20148583 (1) (see all 8)
    breast carcinoma 20.7 1 16484444 (1)
    prostate cancer 14.9 10 12481253 (3), 18279810 (1), 15509676 (1), 10673383 (1)
    colon cancer 7.15 2 16484444 (1), 15509676 (1)
    inflammation 0 1 9870879 (1)

    Genetic Association Database (GAD): ALCAM
    Human Genome Epidemiology (HuGE) Navigator: ALCAM (6 documents)

    Export disorders for ALCAM gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ALCAM gene, integrated from 9 sources (see all 163):
    (articles sorted by number of sources associating them with ALCAM)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, mapping, and characterization of activated leukocyte-cell adhesion molecule (ALCAM), a CD6 ligand. (PubMed id 7760007)1, 2, 3, 9 Bowen M.A....Aruffo A. (1995)
    2. MEMD, a new cell adhesion molecule in metastasizing human melanoma cell lines, is identical to ALCAM (activated leukocyte cell adhesion molecule). (PubMed id 9502422)1, 2, 9 Degen W.G.... Swart G.W. (1998)
    3. Recognition of diverse proteins by members of the immunoglobulin superfamily: delineation of the receptor binding site in the human CD6 ligand ALCAM. (PubMed id 8823162)1, 2, 9 Skonier J.E.... Bajorath J. (1996)
    4. Molecular model of the N-terminal receptor-binding domain of the human CD6 ligand ALCAM. (PubMed id 8520490)1, 2, 9 Bajorath J.... Aruffo A. (1995)
    5. Genetic polymorphisms of adhesion molecules and kidne y transplant survival. (PubMed id 20220571)1, 4, 9 Heinold A....Tran T.H. (2010)
    6. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    7. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (2005)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    9. Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. (PubMed id 12754519)1, 2 Zhang H.... Aebersold R. (2003)
    10. Expression levels of Activated Leukocyte Cell Adhesio n Molecule (ALCAM/CD166) in primary breast carcinoma and distant breast cancer metastases. (PubMed id 20364042)1, 9 Ihnen M....Kilic E. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 214 HGNC: 400 AceView: ALCAM Ensembl:ENSG00000170017 euGenes: HUgn214
    ECgene: ALCAM Kegg: 214 H-InvDB: ALCAM

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ALCAM Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ALCAM Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ALCAM gene:
    Search GeneIP for patents involving ALCAM

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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