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ALCAM Gene

protein-coding   GIFtS: 66
GCID: GC03P105085

Activated Leukocyte Cell Adhesion Molecule

(Previous name: activated leucocyte cell adhesion molecule)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Activated Leukocyte Cell Adhesion Molecule1 2 3
MEMD2 3
CD166 Antigen2 3
Activated Leucocyte Cell Adhesion Molecule1
CD1662

External Ids:    HGNC: 4001   Entrez Gene: 2142   Ensembl: ENSG000001700177   OMIM: 6016625   UniProtKB: Q137403   

Export aliases for ALCAM gene to outside databases

Previous GC identifers: GC03P101874 GC03P104601 GC03P106366 GC03P106406 GC03P106407 GC03P106568 GC03P102460


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ALCAM Gene:
This gene encodes activated leukocyte cell adhesion molecule (ALCAM), also known as CD166 (cluster of
differentiation 166), which is a member of a subfamily of immunoglobulin receptors with five immunoglobulin-like
domains (VVC2C2C2) in the extracellular domain. This protein binds to T-cell differentiation antigene CD6, and is
implicated in the processes of cell adhesion and migration. Multiple alternatively spliced transcript variants
encoding different isoforms have been found. (provided by RefSeq, Aug 2011)

GeneCards Summary for ALCAM Gene:
ALCAM (activated leukocyte cell adhesion molecule) is a protein-coding gene. GO annotations related to this gene include receptor binding. An important paralog of this gene is BCAM.

UniProtKB/Swiss-Prot: CD166_HUMAN, Q13740
Function: Cell adhesion molecule that binds to CD6. Involved in neurite extension by neurons via heterophilic and
homophilic interactions. May play a role in the binding of T- and B-cells to activated leukocytes, as well as in
interactions between cells of the nervous system

Gene Wiki entry for ALCAM Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NC_018914.2  NT_005612.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the ALCAM gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidALCAM promoter sequence
   Search Chromatin IP Primers for ALCAM

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ALCAM


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q13.1   Ensembl cytogenetic band:  3q13.11   HGNC cytogenetic band: 3q13.1

ALCAM Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ALCAM gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P105085:  view genomic region     (about GC identifiers)

Start:
105,085,713 bp from pter      End:
105,295,744 bp from pter
Size:
210,032 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CD166_HUMAN, Q13740 (See protein sequence)
Recommended Name: CD166 antigen precursor  
Size: 583 amino acids; 65102 Da
1 PDB 3D structure from and Proteopedia for ALCAM:
1KJC (3D)    
Secondary accessions: B2RNS3 B4DTU0 O60892 Q1HGM8 Q1HGM9 Q6PEY4 Q6ZS95
Alternative splicing: 4 isoforms:  Q13740-1   Q13740-2   Q13740-3   Q13740-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ALCAM: NX_Q13740

Explore proteomics data for ALCAM at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn91, Asn95, Asn167, Asn265, Asn306, Asn361, Asn457, Asn466, Asn480, Asn499
  • Modification sites at PhosphoSitePlus

  • See ALCAM Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001230209.1  NP_001230210.1  NP_001230212.1  NP_001618.2  

    ENSEMBL proteins: 
     ENSP00000305988   ENSP00000419236   ENSP00000418213   ENSP00000418937   ENSP00000374577  
    Reactome Protein details: Q13740

    ALCAM Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
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    GenScript Custom Purified and Recombinant Proteins Services for ALCAM
    Novus Biologicals ALCAM Proteins
    Sino Biological Recombinant Protein for ALCAM
    Sino Biological Cell Lysate for ALCAM
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ALCAM

     
    Search eBioscience for Proteins for ALCAM 

    ALCAM Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for ALCAM (ALCAM/CD166)
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    Novus Biologicals ALCAM Antibodies
    Abcam antibodies for ALCAM
    Cloud-Clone Corp. Antibodies for ALCAM
    ThermoFisher Antibody for ALCAM
    LSBio Antibodies in human, mouse, rat for ALCAM

    ALCAM Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    R&D Systems ELISAs for ALCAM (ALCAM/CD166)         (see all)
    GenScript Custom Assay Services for ALCAM
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ALCAM
    Cloud-Clone Corp. CLIAs for ALCAM
    Search eBioscience for ELISAs for ALCAM 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    C2SET: Immunoglobulin superfamily / C2-set domain containing
    CD: CD molecules
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing
    VSET: Immunoglobulin superfamily / V-set domain containing

    5 InterPro protein domains:
     IPR013162 CD80_C2-set
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry Q13740

    ProtoNet protein and cluster: Q13740

    2 Blocks protein domains:
    IPB003599 Immunoglobulin subtype
    IPB013162 CD80-like C2-set immunoglobulin


    UniProtKB/Swiss-Prot: CD166_HUMAN, Q13740
    Domain: The CD6 binding site is located in the N-terminal Ig-like domain
    Similarity: Contains 3 Ig-like C2-type (immunoglobulin-like) domains
    Similarity: Contains 2 Ig-like V-type (immunoglobulin-like) domains


    Find genes that share domains with ALCAM           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CD166_HUMAN, Q13740
    Function: Cell adhesion molecule that binds to CD6. Involved in neurite extension by neurons via heterophilic and
    homophilic interactions. May play a role in the binding of T- and B-cells to activated leukocytes, as well as in
    interactions between cells of the nervous system

         Genatlas biochemistry entry for ALCAM:
    activated leukocyte-cell adhesion molecule,CD6 ligand,homologous to rat KG-CAM,chicken neural adhesion molecule

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding TAS7760007
    GO:0005515protein binding ----
         
    Find genes that share ontologies with ALCAM           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for ALCAM:
     Increased gamma-H2AX phosphory  Upregulation of Wnt/beta-caten 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Alcam):
     nervous system  vision/eye 

    Find genes that share phenotypes with ALCAM           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ALCAM
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ALCAM

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ALCAM
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ALCAM

    miRNA
    Products:
        
    miRTarBase miRNAs that target ALCAM:
    hsa-mir-192-5p (MIRT004163), hsa-mir-215-5p (MIRT024327)

    Block miRNA regulation of human, mouse, rat ALCAM using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ALCAM (see all 52):
    hsa-miR-411* hsa-miR-142-5p hsa-miR-323-3p hsa-miR-379* hsa-miR-4328 hsa-miR-449a hsa-miR-192 hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmidALCAM 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ALCAM
    Predesigned siRNA for gene silencing in human, mouse, rat ALCAM

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for ALCAM

    Clone
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    OriGene clones in human, mouse for ALCAM (see all 6)
    OriGene ORF clones in mouse, rat for ALCAM
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ALCAM (NM_001627)
    Sino Biological Human cDNA Clone for ALCAM
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ALCAM
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALCAM

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for ALCAM 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALCAM


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CD166_HUMAN, Q13740: Membrane; Single-pass type I membrane protein
    CD166_HUMAN, Q13740: Isoform 3: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    cytosol2
    extracellular2
    peroxisome2
    cytoskeleton1
    endoplasmic reticulum1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009897external side of plasma membrane IEA--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--
    GO:0030424axon IEA--
    GO:0043025neuronal cell body IEA--

    Find genes that share ontologies with ALCAM           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ALCAM About    
    See pathways by source

    SuperPathContained pathways About
    1L1CAM interactions
    Axon guidance0.63
    L1CAM interactions0.36
    Developmental Biology0.63
    2Cell adhesion molecules (CAMs)
    Cell adhesion molecules (CAMs)


    Find genes that share SuperPaths with ALCAM           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for ALCAM
        L1CAM interactions


    1 Kegg Pathway  (Kegg details for ALCAM):
        Cell adhesion molecules (CAMs)

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ALCAM: 
              Cell Surface Markers in human mouse rat
              Mesenchymal Stem Cell in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ALCAM

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    Selected Interacting proteins for ALCAM (Q137403 ENSP000003059884) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CD6P302033, ENSP000003232804I2D: score=3 STRING: ENSP00000323280
    RELAQ042063, ENSP000003842734I2D: score=1 STRING: ENSP00000384273
    EGFRP005333, ENSP000002754934I2D: score=3 STRING: ENSP00000275493
    L1CAMENSP000003590744STRING: ENSP00000359074
    PIGQENSP000000262184STRING: ENSP00000026218
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion IEA--
    GO:0007165signal transduction TAS7760007
    GO:0007411axon guidance TAS--
    GO:0008045motor neuron axon guidance IEA--

    Find genes that share ontologies with ALCAM           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ALCAM (CD166)

    3 Novoseek inferred chemical compound relationships for ALCAM gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    estrogen 7.7 6 18810438 (2), 16810131 (1), 16865058 (1), 18172759 (1)
    progesterone 0 1 16810131 (1)
    tyrosine 0 1 15618003 (1)



    Find genes that share compounds with ALCAM           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ALCAM gene (4 alternative transcripts): 
    NM_001243280.1  NM_001243281.1  NM_001243283.1  NM_001627.3  

    Unigene Cluster for ALCAM:

    Activated leukocyte cell adhesion molecule
    Hs.591293  [show with all ESTs]
    Unigene Representative Sequence: NM_001627
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000306107(uc003dvw.2 uc003dvx.3 uc003dvy.3 uc010hpp.3 uc003dvz.3)
    ENST00000470756(uc003dvv.3) ENST00000472644 ENST00000481337(uc011bhh.1)
    ENST00000486979 ENST00000460954 ENST00000465413 ENST00000491388 ENST00000489178
    ENST00000389927
    miRNA
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    Block miRNA regulation of human, mouse, rat ALCAM using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ALCAM (see all 52):
    hsa-miR-411* hsa-miR-142-5p hsa-miR-323-3p hsa-miR-379* hsa-miR-4328 hsa-miR-449a hsa-miR-192 hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmidALCAM 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for ALCAM
    Predesigned siRNA for gene silencing in human, mouse, rat ALCAM
    Clone
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    OriGene clones in human, mouse for ALCAM (see all 6)
    OriGene ORF clones in mouse, rat for ALCAM
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ALCAM (NM_001627)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ALCAM
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALCAM
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for ALCAM
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ALCAM
      QuantiTect SYBR Green Assays in human, mouse, rat ALCAM
      QuantiFast Probe-based Assays in human, mouse, rat ALCAM

    Additional mRNA sequence: 

    AK054632.1 AK095833.1 AK127617.1 AK300362.1 AK301804.1 AK316113.1 AL833702.1 AY644765.1 
    BC029639.1 BC041127.1 BC057809.1 BC137096.1 BC137097.1 DQ486139.1 DQ486140.1 L38608.1 
    Y10183.1 

    15 DOTS entries:

    DT.451628  DT.40107844  DT.95170077  DT.99975109  DT.99990630  DT.100810542  DT.91752875  DT.100822887 
    DT.100043266  DT.91752878  DT.92041066  DT.91643802  DT.99965331  DT.80101947  DT.91752865 

    Selected AceView cDNA sequences (see all 403):

    BM757832 AI082099 BU178192 BM973425 AA029282 F06946 AL041869 N26375 
    BM679709 CA425631 BM972494 BM994993 BC057809 AA304516 AI285827 AI623932 
    AA703922 AW172541 BM984274 H99250 AI218908 BU741679 AL703362 AI050952 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ALCAM (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b
    SP1:                          -                                   -                                   -                 -                     
    SP2:                                                  -     -     -                                   -                 -                     
    SP3:                                                                                                  -                 -                     
    SP4:                                                                                                  -     -           -                     
    SP5:                                                                                                                                          


    ECgene alternative splicing isoforms for ALCAM

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ALCAM expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACGAAGATG
    ALCAM Expression
    About this image


    ALCAM expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 27) fully expand
     
     Mesenchymal Stem Cells
             Chorionic Mesenchymal Stromal Cells Chorionic Villus
             Decidua-derived mesenchymal cells
             Mesenchymal-like stem cells
     
     Bone (Muscoskeletal System)    fully expand to see all 14 entries
             Mesenchymal Stem Cells Zeugopod Periosteum
             Bone marrow-derived mesenchymal stem cells
     
     Tooth (Integumentary System)    fully expand to see all 8 entries
             Dental Pulp Stem Cells Dental Pulp
             Stem cells from human exfoliated deciduous teeth (family)
     
     Placenta (Extraembryonic Tissues)    fully expand to see all 4 entries
             Chorionic Mesenchymal Stromal Cells Chorionic Villus
             Decidua-derived mesenchymal cells
     
     Liver (Hepatobiliary System)    fully expand to see all 5 entries
             Mesothelial Cells Hepatic Mesenchyme
    ALCAM Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ALCAM Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.591293

    UniProtKB/Swiss-Prot: CD166_HUMAN, Q13740
    Tissue specificity: Spleen, placenta, liver, and weakly in liver. Expressed by activated T-cells, B-cells,
    monocytes and thymic epithelial cells. Expressed by neurons in the brain. Restricted expression in tumor cell
    lines. Preferentially expressed in highly metastasizing melanoma cell lines

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ALCAM: 
              Cell Surface Markers in human mouse rat
              Mesenchymal Stem Cell in human mouse rat

    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for ALCAM
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ALCAM
    QuantiTect SYBR Green Assays in human, mouse, rat ALCAM
    QuantiFast Probe-based Assays in human, mouse, rat ALCAM
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALCAM

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for ALCAM gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Alcam1 , 5 activated leukocyte cell adhesion molecule1, 5 89.25(n)1
    92.97(a)1
      16 (32.88 cM)5
    116581  NM_009655.21  NP_033785.11 
     522489965 
    chicken
    (Gallus gallus)
    Aves ALCAM1 activated leukocyte cell adhesion molecule 76.87(n)
    74.96(a)
      396092  NM_205179.1  NP_990510.1 
    lizard
    (Anolis carolinensis)
    Reptilia ALCAM6
    activated leukocyte cell adhesion molecule
    72(a)
    1 ↔ 1
    3(170815551-170889257)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.16432 Xenopus laevis transcribed sequence with weak similarity more 77.93(n)    BU907815.1 
    zebrafish
    (Danio rerio)
    Actinopterygii alcama1 activated leukocyte cell adhesion molecule a 49.4(n)
    40.58(a)
      30194  NM_131000.1  NP_571075.1 


    ENSEMBL Gene Tree for ALCAM (if available)
    TreeFam Gene Tree for ALCAM (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ALCAM gene
    BCAM2  MCAM2  
    2 SIMAP similar genes for ALCAM using alignment to 3 protein entries:     CD166_HUMAN (see all proteins):
    AGER    IGLV3-27

    Find genes that share paralogs with ALCAM           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ALCAM (see all 3830)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2021080891,2
    C--102483037(+) TTTTTC/TCTAAA 4 -- int10--------
    rs766671591,2
    C--102487536(+) GTTTT-/CCACAT 4 -- int10--------
    rs2001400351,2
    --102498320(+) AAAAA-/TAAAAC 4 -- int10--------
    rs1419009191,2
    C--102498942(+) AAAAA-/GACAAAGA 4 -- int10--------
    rs67750361,2
    C,A--102498943(+) aaaagA/C/Gcaaag 4 -- int1 trp30--------
    rs754072111,2
    C--102502970(+) GTGAC-/ATATATA 4 -- int10--------
    rs1507933421,2
    C--102542114(+) CCATT-/A/AA  
            
    TAAAA
    4 -- int10--------
    rs759999031,2
    C--102544798(+) CAAAG-/AAGT  
            
    AAGTA
    4 -- int10--------
    rs1396290001,2
    C--102544799(+) CAAAG-/AAGT  
            
    AAGTA
    4 -- int10--------
    rs789063001,2
    --102562892(+) GCGGGG/TTTTTT 4 -- int11Minor allele frequency- T:0.50CSA 2

    HapMap Linkage Disequilibrium report for ALCAM (105085713 - 105295744 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for ALCAM:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv829651CNV Loss17160897
    nsv509844CNV Loss20534489
    nsv877304CNV Gain21882294
    nsv525071CNV Gain19592680
    nsv829650CNV Gain17160897
    nsv460811CNV Gain19166990

    Human Gene Mutation Database (HGMD): ALCAM
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ALCAM
    DNA2.0 Custom Variant and Variant Library Synthesis for ALCAM

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601662    OMIM disorders: --


    Find genes that share disorders with ALCAM           About GenesLikeMe

    Selected Novoseek inferred disease relationships for ALCAM gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    melanoma 41.3 17 10702391 (4), 15140234 (2), 9502422 (2), 18279810 (1) (see all 6)
    metastasis 35.1 31 18202807 (5), 20364042 (5), 15318930 (4), 15140234 (1) (see all 9)
    primary tumor 33.3 7 15140234 (2), 20208136 (1), 20364042 (1), 10702391 (1) (see all 6)
    tumors 29.6 65 16818742 (5), 16810131 (4), 15318930 (4), 20208136 (2) (see all 14)
    breast cancer 24.6 29 15318930 (6), 18202807 (4), 16810131 (4), 16484444 (3) (see all 9)
    cancer 23.1 14 19157844 (2), 20180536 (1), 18202807 (1), 20148583 (1) (see all 8)
    breast carcinoma 20.7 1 16484444 (1)
    prostate cancer 14.9 10 12481253 (3), 18279810 (1), 15509676 (1), 10673383 (1)
    colon cancer 7.15 2 16484444 (1), 15509676 (1)
    inflammation 0 1 9870879 (1)

    Genetic Association Database (GAD): ALCAM
    Human Genome Epidemiology (HuGE) Navigator: ALCAM (6 documents)

    Export disorders for ALCAM gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ALCAM gene, integrated from 10 sources (see all 168):
    (articles sorted by number of sources associating them with ALCAM)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, mapping, and characterization of activated leukocyte-cell adhesion molecule (ALCAM), a CD6 ligand. (PubMed id 7760007)1, 2, 3, 9 Bowen M.A....Aruffo A. (J. Exp. Med. 1995)
    2. Molecular isolation and characterization of a soluble isoform of activated leukocyte cell adhesion molecule that modulates endothelial cell function. (PubMed id 15496415)1, 2, 9 Ikeda K. and Quertermous T. (J. Biol. Chem. 2004)
    3. MEMD, a new cell adhesion molecule in metastasizing human melanoma cell lines, is identical to ALCAM (activated leukocyte cell adhesion molecule). (PubMed id 9502422)1, 2, 9 Degen W.G.... Swart G.W. (Am. J. Pathol. 1998)
    4. Recognition of diverse proteins by members of the immunoglobulin superfamily: delineation of the receptor binding site in the human CD6 ligand ALCAM. (PubMed id 8823162)1, 2, 9 Skonier J.E.... Bajorath J. (Biochemistry 1996)
    5. Molecular model of the N-terminal receptor-binding domain of the human CD6 ligand ALCAM. (PubMed id 8520490)1, 2, 9 Bajorath J.... Aruffo A. (Protein Sci. 1995)
    6. Genetic polymorphisms of adhesion molecules and kidney transplant survival. (PubMed id 20220571)1, 4, 9 Heinold A....Tran T.H. (Transplantation 2010)
    7. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    8. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (J. Proteome Res. 2005)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. (PubMed id 12754519)1, 2 Zhang H.... Aebersold R. (Nat. Biotechnol. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 214 HGNC: 400 AceView: ALCAM Ensembl:ENSG00000170017 euGenes: HUgn214
    ECgene: ALCAM Kegg: 214 H-InvDB: ALCAM

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ALCAM Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ALCAM Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for ALCAM gene:
    Search GeneIP for patents involving ALCAM

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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