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Aliases for ALCAM Gene

Aliases for ALCAM Gene

  • Activated Leukocyte Cell Adhesion Molecule 2 3 4
  • CD166 Antigen 3 4
  • MEMD 3 4
  • Activated Leucocyte Cell Adhesion Molecule 2
  • CD166 3

External Ids for ALCAM Gene

Summaries for ALCAM Gene

Entrez Gene Summary for ALCAM Gene

  • This gene encodes activated leukocyte cell adhesion molecule (ALCAM), also known as CD166 (cluster of differentiation 166), which is a member of a subfamily of immunoglobulin receptors with five immunoglobulin-like domains (VVC2C2C2) in the extracellular domain. This protein binds to T-cell differentiation antigene CD6, and is implicated in the processes of cell adhesion and migration. Multiple alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Aug 2011]

GeneCards Summary for ALCAM Gene

ALCAM (Activated Leukocyte Cell Adhesion Molecule) is a Protein Coding gene. Among its related pathways are L1CAM interactions and L1CAM interactions. GO annotations related to this gene include receptor binding. An important paralog of this gene is MCAM.

UniProtKB/Swiss-Prot for ALCAM Gene

  • Cell adhesion molecule that binds to CD6. Involved in neurite extension by neurons via heterophilic and homophilic interactions. May play a role in the binding of T- and B-cells to activated leukocytes, as well as in interactions between cells of the nervous system

Gene Wiki entry for ALCAM Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ALCAM Gene

Genomics for ALCAM Gene

Genomic Location for ALCAM Gene

Start:
105,366,713 bp from pter
End:
105,576,913 bp from pter
Size:
210,201 bases
Orientation:
Plus strand

Genomic View for ALCAM Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ALCAM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ALCAM Gene

Regulatory Elements for ALCAM Gene

Transcription factor binding sites by QIAGEN in the ALCAM gene promoter:

Proteins for ALCAM Gene

  • Protein details for ALCAM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13740-CD166_HUMAN
    Recommended name:
    CD166 antigen
    Protein Accession:
    Q13740
    Secondary Accessions:
    • B2RNS3
    • B4DTU0
    • O60892
    • Q1HGM8
    • Q1HGM9
    • Q6PEY4
    • Q6ZS95

    Protein attributes for ALCAM Gene

    Size:
    583 amino acids
    Molecular mass:
    65102 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for ALCAM Gene

    Alternative splice isoforms for ALCAM Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ALCAM Gene

Proteomics data for ALCAM Gene at MOPED

Post-translational modifications for ALCAM Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn91, Asn95, Asn167, Asn265, Asn306, Asn361, Asn457, Asn466, Asn480, and Asn499

Other Protein References for ALCAM Gene

No data available for DME Specific Peptides for ALCAM Gene

Domains for ALCAM Gene

Gene Families for ALCAM Gene

HGNC:
  • CD :CD molecules
  • VSET :Immunoglobulin superfamily / V-set domain containing
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing
  • C2SET :Immunoglobulin superfamily / C2-set domain containing

Graphical View of Domain Structure for InterPro Entry

Q13740

UniProtKB/Swiss-Prot:

CD166_HUMAN
Domain:
  • The CD6 binding site is located in the N-terminal Ig-like domain.:
    • Q13740
  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.:
    • Q13740
  • Contains 2 Ig-like V-type (immunoglobulin-like) domains.:
    • Q13740
genes like me logo Genes that share domains with ALCAM: view

Function for ALCAM Gene

Molecular function for ALCAM Gene

GENATLAS Biochemistry: activated leukocyte-cell adhesion molecule,CD6 ligand,homologous to rat KG-CAM,chicken neural adhesion molecule
UniProtKB/Swiss-Prot Function: Cell adhesion molecule that binds to CD6. Involved in neurite extension by neurons via heterophilic and homophilic interactions. May play a role in the binding of T- and B-cells to activated leukocytes, as well as in interactions between cells of the nervous system

Gene Ontology (GO) - Molecular Function for ALCAM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding TAS 7760007
GO:0005515 protein binding IPI 24945728
genes like me logo Genes that share ontologies with ALCAM: view
genes like me logo Genes that share phenotypes with ALCAM: view

miRNA for ALCAM Gene

miRTarBase miRNAs that target ALCAM

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ALCAM Gene

Localization for ALCAM Gene

Subcellular locations from UniProtKB/Swiss-Prot for ALCAM Gene

Membrane; Single-pass type I membrane protein.
Isoform 3: Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ALCAM Gene COMPARTMENTS Subcellular localization image for ALCAM gene
Compartment Confidence
plasma membrane 3
cytosol 2
extracellular 2
peroxisome 2
cytoskeleton 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for ALCAM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005925 focal adhesion IDA 21423176
GO:0009897 external side of plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030424 axon IEA --
GO:0043025 neuronal cell body IEA --
genes like me logo Genes that share ontologies with ALCAM: view

Pathways for ALCAM Gene

genes like me logo Genes that share pathways with ALCAM: view

Pathways by source for ALCAM Gene

3 Reactome pathways for ALCAM Gene
1 KEGG pathway for ALCAM Gene

Gene Ontology (GO) - Biological Process for ALCAM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0007165 signal transduction TAS 7760007
GO:0007411 axon guidance TAS --
GO:0008045 motor neuron axon guidance IEA --
genes like me logo Genes that share ontologies with ALCAM: view

Compounds for ALCAM Gene

(3) Novoseek inferred chemical compound relationships for ALCAM Gene

Compound -log(P) Hits PubMed IDs
estrogen 7.7 5
progesterone 0 1
tyrosine 0 1
genes like me logo Genes that share compounds with ALCAM: view

Transcripts for ALCAM Gene

Unigene Clusters for ALCAM Gene

Activated leukocyte cell adhesion molecule:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ALCAM Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b
SP1: - - - -
SP2: - - - - -
SP3: - -
SP4: - - -
SP5:
SP6:
SP7:

Relevant External Links for ALCAM Gene

GeneLoc Exon Structure for
ALCAM
ECgene alternative splicing isoforms for
ALCAM

Expression for ALCAM Gene

mRNA expression in normal human tissues for ALCAM Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ALCAM Gene

SOURCE GeneReport for Unigene cluster for ALCAM Gene Hs.591293

mRNA Expression by UniProt/SwissProt for ALCAM Gene

Q13740-CD166_HUMAN
Tissue specificity: Spleen, placenta, liver, and weakly in liver. Expressed by activated T-cells, B-cells, monocytes and thymic epithelial cells. Expressed by neurons in the brain. Restricted expression in tumor cell lines. Preferentially expressed in highly metastasizing melanoma cell lines.
genes like me logo Genes that share expressions with ALCAM: view

No data available for mRNA differential expression in normal tissues for ALCAM Gene

Orthologs for ALCAM Gene

This gene was present in the common ancestor of chordates.

Orthologs for ALCAM Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ALCAM 35
  • 99.37 (n)
  • 99.83 (a)
ALCAM 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ALCAM 35
  • 93.42 (n)
  • 94.68 (a)
ALCAM 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ALCAM 35
  • 93.48 (n)
  • 95.54 (a)
ALCAM 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Alcam 35
  • 89.25 (n)
  • 92.97 (a)
Alcam 16
Alcam 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ALCAM 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ALCAM 36
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Alcam 35
  • 89.65 (n)
  • 93.31 (a)
chicken
(Gallus gallus)
Aves ALCAM 35
  • 76.87 (n)
  • 74.96 (a)
ALCAM 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ALCAM 36
  • 72 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.1643 35
tropical clawed frog
(Silurana tropicalis)
Amphibia alcam 35
  • 63.59 (n)
  • 57.79 (a)
Str.15872 35
zebrafish
(Danio rerio)
Actinopterygii alcama 35
  • 49.4 (n)
  • 40.58 (a)
alcama 36
  • 37 (a)
OneToMany
alcamb 36
  • 37 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 18 (a)
OneToMany
Species with no ortholog for ALCAM:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ALCAM Gene

ENSEMBL:
Gene Tree for ALCAM (if available)
TreeFam:
Gene Tree for ALCAM (if available)

Paralogs for ALCAM Gene

Paralogs for ALCAM Gene

Selected SIMAP similar genes for ALCAM Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ALCAM: view

Variants for ALCAM Gene

Sequence variations from dbSNP and Humsavar for ALCAM Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs1157 -- 105,576,617(-) TTTCC(C/T)GGCAA utr-variant-3-prime
rs1524 -- 105,492,667(-) GTCTT(C/T)GAGGA intron-variant
rs9370 -- 105,576,837(+) ATTGT(A/T)TGTGG utr-variant-3-prime
rs14550 -- 105,576,707(+) CGAAG(A/G)TGCTA utr-variant-3-prime
rs474355 -- 105,558,125(-) ATTGA(C/T)ACCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ALCAM Gene

Variant ID Type Subtype PubMed ID
nsv525071 CNV Gain 19592680
nsv829650 CNV Gain 17160897
nsv877304 CNV Gain 21882294
nsv829651 CNV Loss 17160897
nsv509844 CNV Loss 20534489
nsv460811 CNV Gain 19166990

Relevant External Links for ALCAM Gene

HapMap Linkage Disequilibrium report
ALCAM
Human Gene Mutation Database (HGMD)
ALCAM

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ALCAM Gene

Disorders for ALCAM Gene

(12) Novoseek inferred disease relationships for ALCAM Gene

Disease -log(P) Hits PubMed IDs
melanoma 41.3 11
metastasis 35.1 20
primary tumor 33.3 7
tumors 29.6 28
breast cancer 24.6 26

Relevant External Links for ALCAM

Genetic Association Database (GAD)
ALCAM
Human Genome Epidemiology (HuGE) Navigator
ALCAM
genes like me logo Genes that share disorders with ALCAM: view

No data available for UniProtKB/Swiss-Prot for ALCAM Gene

Publications for ALCAM Gene

  1. Cloning, mapping, and characterization of activated leukocyte-cell adhesion molecule (ALCAM), a CD6 ligand. (PMID: 7760007) Bowen M.A. … Aruffo A. (J. Exp. Med. 1995) 2 3 4 23
  2. Molecular model of the N-terminal receptor-binding domain of the human CD6 ligand ALCAM. (PMID: 8520490) Bajorath J. … Aruffo A. (Protein Sci. 1995) 3 4 23
  3. Recognition of diverse proteins by members of the immunoglobulin superfamily: delineation of the receptor binding site in the human CD6 ligand ALCAM. (PMID: 8823162) Skonier J.E. … Bajorath J. (Biochemistry 1996) 3 4 23
  4. MEMD, a new cell adhesion molecule in metastasizing human melanoma cell lines, is identical to ALCAM (activated leukocyte cell adhesion molecule). (PMID: 9502422) Degen W.G. … Swart G.W. (Am. J. Pathol. 1998) 3 4 23
  5. Molecular isolation and characterization of a soluble isoform of activated leukocyte cell adhesion molecule that modulates endothelial cell function. (PMID: 15496415) Ikeda K. … Quertermous T. (J. Biol. Chem. 2004) 3 4 23

Products for ALCAM Gene

Sources for ALCAM Gene

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