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ALCAM Gene

protein-coding GIFtS: 63

GC03P106568

activated leukocyte cell adhesion molecule
(Previous name: activated leucocyte cell adhesion molecule )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CD166 ^¹, ²
FLJ38514 ^²
MEMD ^¹, ², ³
MGC71733 ^²

Descriptions
CD166 antigen ^³
activated leucocyte cell adhesion molecule ^¹, ²
activated leukocyte cell adhesion molecule ^², ³

External Ids
HGNC: 400¹
Entrez Gene: 214²
UniProtKB: Q13740³
Ensembl: ENSG00000170017⁷

Search outside databases for aliases for ALCAM gene

Previous GC identifers: GC03P101874 GC03P104601 GC03P106366 GC03P106406 GC03P106407

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: CD166_HUMAN, Q13740

Function: Cell adhesion molecule that binds to CD6. Involved in neurite extension by neurons via

heterophilic and homophilic interactions. May play a role in the binding of T- and B-cells to

activated leukocytes, as well as in interactions between cells of the nervous system

Gene Wiki entry for ALCAM

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ALCAM gene

Entrez Gene cytogenetic band: 3q13.1 Ensembl cytogenetic band: 3q13.11 HGNC cytogenetic band: 3q13.1

ALCAM Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03P106568: (about GC identifiers)

Start:	106,568,403 bp from pter
End:	106,778,434 bp from pter
Size:	210,032 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000003.10 NT_005612.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: CD166_HUMAN, Q13740 (See protein sequence)

Recommended Name: CD166 antigen precursor

Size: 583 amino acids; 65102 Da

Subcellular location: Membrane; Single-pass type I membrane protein

PDB structures from and Proteopedia :

1KJC (3D)

Secondary accessions: B2RNS3 O60892 Q1HGM8 Q1HGM9

Alternative splicing: 2 isoforms: Q13740-1 Q13740-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_001618.2

ENSEMBL proteins:

ENSP00000305988 ENSP00000374577 ENSP00000374576

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich Proteins for ALCAM
	R&D Systems Recombinant & Natural Proteins for ALCAM (ALCAM/CD166)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (CD166)
	Human Recombinant Proteins from Abnova (ALCAM)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016020	membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

About this table

Antibodies for ALCAM:

	Invitrogen Antibodies for ALCAM
	Millipore Mono- and Polyclonal Antibodies for the study of ALCAM
	Sigma-Aldrich Antibodies for ALCAM
	R&D Systems Antibodies for ALCAM (ALCAM/CD166)
	Antibodies from Abcam (CD166), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ALCAM)
	Novus Biologicals Antibodies for ALCAM

Assays for ALCAM:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	R&D Systems ELISAs for ALCAM (ALCAM/CD166) (see all)
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q13740

ProtoNet protein and cluster: Q13740

2 Blocks protein families:

IPB003599 Immunoglobulin subtype

IPB013162 CD80-like C2-set immunoglobulin

UniProtKB/Swiss-Prot: CD166_HUMAN, Q13740

Domain: The CD6 binding site is located in the N-terminal Ig-like domain

Similarity: Contains 3 Ig-like C2-type (immunoglobulin-like) domains

Similarity: Contains 2 Ig-like V-type (immunoglobulin-like) domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ALCAM)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ALCAM)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001627

Applied Biosystems Silencer® siRNAs for ALCAM

Sigma-Aldrich siRNA and siRNA Panels for ALCAM

Sigma-Aldrich shRNA Panels and shRNA for ALCAM

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ALCAM
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001627
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001627
untagged cDNA clone in CMV expression vector: NM_001627

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001627

UniProtKB/Swiss-Prot: CD166_HUMAN, Q13740

Function: Cell adhesion molecule that binds to CD6. Involved in neurite extension by neurons via

heterophilic and homophilic interactions. May play a role in the binding of T- and B-cells to

activated leukocytes, as well as in interactions between cells of the nervous system

Genatlas biochemistry entry for ALCAM:

activated leukocyte-cell adhesion molecule,CD6 ligand,homologous to rat KG-CAM,chicken neural

adhesion molecule

2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Alcam):

nervous system

vision/eye

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005102	receptor binding	TAS	7760007

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for ALCAM

5/32 Interacting proteins for ALCAM (ENSP00000374576³) via UniProtKB, MINT, and/or STRING (see all 32 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CD6	ENSP00000323280³	STRING (score=.999)
NCAN	ENSP00000252575³	STRING (score=.947)
PTPRZ1	ENSP00000265220³	STRING (score=.947)
BARX2	ENSP00000281437³	STRING (score=.906)
GPSN2	ENSP00000215567³	STRING (score=.902)

About this table

2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007155	cell adhesion	TAS	7760007
GO:0007165	signal transduction	TAS	7760007

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ALCAM
2 Novoseek chemical compound relationships for ALCAM gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
progesterone	0.00	1	16810131 (1)
tyrosine	0.00	1	15618003 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ALCAM)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ALCAM)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001627

Sigma-Aldrich siRNA and siRNA Panels for ALCAM

Sigma-Aldrich shRNA Panels and shRNA for ALCAM

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001627

REFSEQ mRNAs for ALCAM gene:

NM_001627.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001627

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001627
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001627
                                 untagged cDNA clone in CMV expression vector: NM_001627

Additional cDNA sequence:

AB074167.1 AF086091.1 AK054632.1 AK095833.1 AK127617.1 AK300362.1 AK301804.1 AK316113.1

AL833702.1 AY644765.1 BC029639.1 BC041127.1 BC057809.1 BC137096.1 BC137097.1 DQ486139.1

DQ486140.1 L38608.1 Y10183.1

18 DOTS entries:

DT.451628 DT.95170077 DT.40107844 DT.99975109 DT.91752875 DT.100810542 DT.99990630 DT.100043266

DT.100822887 DT.435942 DT.91752878 DT.92041066 DT.91643802 DT.99965331 DT.80101947 DT.91752865

DT.91752876 DT.97823455

24/403 AceView cDNA sequences (see all 403 ):

F06946 BU838382 AU118527 BG674686 T32027 BP380341 BM679709 BU741679

BM973425 AA156842 AI693132 W73410 CB178462 BC041127 Z40035 BM971365

N76480 BU629686 BM994993 AA777157 BE043005 AI435550 AI358995 AW242676

highest scoring ESTs for ALCAM:

Y10183 AA029282 AA085490 AA085507 AA127889 AA156604 AA156721 AA156810 AA160065 AA160066

Unigene Cluster for ALCAM:

Activated leukocyte cell adhesion molecule

Hs.591293 [show with all ESTs]

Unigene Representative Sequence: NM_001627

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for ALCAM (see all 7 )

ExUns:	1a	·	1b	^	2	^	3a	·	3b	^	4	^	5	^	6	^	7	^	8	^	9a	·	9b	^	10a	·	10b	^	11	^	12a	·	12b	^	13	^	14	^	15	^	16	^	17a	·	17b
SP1:									-												-												-						-
SP2:																	-		-		-												-						-
SP3:																																	-						-
SP4:																																	-		-				-
SP5:

About this scheme

ECgene alternative splicing isoforms for ALCAM

3 Ensembl transcripts including schematic representations:

ENST00000306107 ENST00000389927 ENST00000389926

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ALCAM expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ALCAM

¹ / ² / ³

5 probe-sets matching ALCAM gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
38642_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	Y10183	1.00	1.00	1.00	1
201951_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BF242905	0.80	1.00	0.91	1
201952_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AA156721	0.80	1.00	0.91	1
201951_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
201952_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks ALCAM for binary patterns associated with the probe-sets selected above

About GeneDecksing

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CACGAAGATG

SOURCE GeneReport for Unigene cluster: Hs.591293
Expression variation in blood from EXPOLDB for ALCAM
UniProtKB/Swiss-Prot: CD166_HUMAN, Q13740
Tissue specificity: Spleen, placenta, liver, and weakly in liver. Expressed by activated T-cells,
B-cells, monocytes and thymic epithelial cells. Expressed by neurons in the brain. Restricted
expression in tumor cell lines. Preferentially expressed in highly metastasizing melanoma cell
lines

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ALCAM gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ALCAM¹	--	activated leukocyte cell adhesion molecule	93.48(n) 96.6(a)	478550 XM_535727.2 XP_535727.2
chimpanzee (Pan troglodytes)	ALCAM¹	--	activated leukocyte cell adhesion molecule	99.37(n) 99.83(a)	460565 XM_516634.2 XP_516634.2
cow (Bos taurus)	ALCAM¹	--	activated leukocyte cell adhesion molecule	93.42(n) 94.68(a)	281614 NM_174238.1 NP_776663.1
rat (Rattus norvegicus)	Alcam¹	--	activated leukocyte cell adhesion molecule	89.65(n) 93.31(a)	79559 NM_031753.1 NP_113941.1
mouse (Mus musculus)	Alcam^{1, 5}	16⁵	activated leukocyte cell adhesion molecule^{1, 5}	89.25(n)¹ 92.97(a)¹	11658¹ NM_009655.1¹ NP_033785.1¹ AB003026⁵ AI853494⁵ (see all 16)

About this table Species with no ortholog for ALCAM

ENSEMBL Gene Tree for ALCAM

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ALCAM gene

BCAM² MCAM²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/960 NCBI SNPs in ALCAM are shown (see all 960 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 364)

AB	SNP ID	Valid	Chr 3 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1157^1,2	A,C,F,H,O	106778151(-)	`TTTCCC/TGGCAA`	1	--	ut3¹ ese³ trp³		9	MN EU EA WA NA	734
	rs6437585^1,2	A,C,F,H	106568775(+)	`GCGTGC/TGGCAG`	1	--	ut5¹ ese³		4	EU EA WA	418
--	rs6790496^1,2	A,C,F	106777224(+)	`AGACCA/GGATAT`	1	--	ut3¹		1	MN	184
	rs10933819^1,2	C,F,H	106736335(+)	`ATCTGG/ACCAGA`	1	D/G	mis¹ ese³		8	EU EA WA	836
	rs11559013^1,2	C,F,H	106777192(+)	`AGGTGG/ATAGTA`	1	--	ut3¹		3	EU EA	266
	rs490029^1,2	A,C,F	106777672(-)	`ATAACG/ATATTT`	1	--	ut3¹ ese³		1	MN	184
	rs2291375^1,2	C,F,H	106746819(-)	`TGACAC/TGGGTA`	1	V/M	mis¹ ese³		8	EU EA WA	840
	rs1044240^1,2	C,F,H	106741551(+)	`AAAAAA/GTGCCA`	1	N/S	mis¹		12	NA MN EU EA WA	1140
--	rs1044243^1,2	C,F,H	106743210(+)	`ACTAAC/TGGATG`	1	T/M	mis¹ ese³		15	MN NA EU EA WA	1282
	rs6765665^1,2	F,H	106776816(+)	`CATTCC/TCATTT`	1	--	ut3¹		4	EU EA WA	418

About this table

HapMap Linkage Disequilibrium images for ALCAM (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 601662

10/12 Novoseek disease relationships for ALCAM gene (see all 12 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
melanoma	41.59	17	10702391 (4), 15140234 (2), 9502422 (2), 18279810 (1) (see all 6)
metastasis	28.67	15	18202807 (5), 15318930 (4), 15140234 (1), 16810131 (1) (see all 7)
tumors	26.02	51	16818742 (5), 16810131 (4), 15318930 (4), 19142865 (2) (see all 10)
primary tumor	25.98	5	15140234 (2), 10702391 (1), 18172759 (1), 15318930 (1)
breast cancer	25.04	27	15318930 (6), 18202807 (4), 16810131 (4), 16484444 (3) (see all 8)
prostate cancer	18.33	10	12481253 (3), 18279810 (1), 15509676 (1), 10673383 (1)
cancer	17.80	11	19157844 (2), 18202807 (1), 19142865 (1), 15148921 (1) (see all 5)
breast carcinoma	14.20	1	16484444 (1)
colon cancer	0.00	2	16484444 (1), 15509676 (1)
inflammation	0.00	1	9870879 (1)

About this table

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/97 PubMed articles for ALCAM gene (see all 97 ):

Cloning, mapping, and characterization of activated leukocyte-cell adhesion molecule (ALCAM), a CD6 ligand. (PubMed id 7760007)^{1, 2, 3, 4} Bowen M.A....Aruffo A. (1995)
MEMD, a new cell adhesion molecule in metastasizing human melanoma cell lines, is identical to ALCAM (activated leukocyte cell adhesion molecule). (PubMed id 9502422)^{1, 3, 4} Degen W.G.... Swart G.W. (1998)
Recognition of diverse proteins by members of the immunoglobulin superfamily: delineation of the receptor binding site in the human CD6 ligand ALCAM. (PubMed id 8823162)^{1, 3, 4} Skonier J.E.... Bajorath J. (1996)
Molecular model of the N-terminal receptor-binding domain of the human CD6 ligand ALCAM. (PubMed id 8520490)^{1, 3, 4} Bajorath J.... Aruffo A. (1995)
Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)^{3, 4} Liu T.... Smith R.D. (2005)
Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. (PubMed id 12754519)^{3, 4} Zhang H.... Aebersold R. (2003)
Molecular isolation and characterization of a soluble isoform of activated leukocyte cell adhesion molecule that modulates endothelial cell function. (PubMed id 15496415)^{1, 3} Ikeda K. and Quertermous T. (2004)
Expression of the cell to cell adhesion molecule, ALCAM, in breast cancer patients and the potential link with skeletal metastasis. (PubMed id 18202807)^{1, 3} Davies S.R....Jiang W.G. (2008)
ALCAM/CD166 is up-regulated in low-grade prostate cancer and progressively lost in high-grade lesions. (PubMed id 12481253)^{1, 3} Kristiansen G....Rosenthal A. (2003)
Cytoplasmic accumulation of activated leukocyte cell adhesion molecule is a predictor of disease progression and reduced survival in oral cancer patients. (PubMed id 19142865)^{1, 3} Sawhney M....Ralhan R. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 214	HGNC: 400	AceView: ALCAM	Ensembl:ENSG00000170017	euGenes: HUgn214
ECgene: ALCAM	H-InvDB: ALCAM

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for ALCAM	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for ALCAM
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ALCAM:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ALCAM-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ALCAM		Antibodies for ALCAM
	Explore super-pooled esiRNAs		Proteins for ALCAM
	Lentivirus-delivered shRNAs for ALCAM		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (ALCAM)
	Antibodies (ALCAM)
	Chimera RNAi (ALCAM)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (CD166)
	Antibodies (CD166)

Search OriGene for ALCAM

Search Tocris compounds for ALCAM

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for ALCAM

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
ALCAM Gene at Home site.
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ALCAM Gene

protein-coding GIFtS: 63

Aliases &
Descriptions
for ALCAM

Summaries
for ALCAM

Genomic Location
for ALCAM

Proteins
for ALCAM

Protein Domains/
Families
for ALCAM

Gene Function
for ALCAM

Pathways & Interactions
for ALCAM

Drugs & Compounds
for ALCAM

Transcripts
for ALCAM

Expression
for ALCAM

Orthologs
for ALCAM

Paralogs
for ALCAM

SNPs/Variants
for ALCAM

Disorders & Mutations
for ALCAM

Medical News
for ALCAM

Publications
for ALCAM

Search for ALCAM

Genome Databases showing ALCAM

Other Databases showing ALCAM

Specialized Databases showing ALCAM

Licensable Technologies
for ALCAM

Services
for ALCAM

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ALCAM Gene

protein-coding GIFtS: 63

Aliases & Descriptionsfor ALCAM

Summariesfor ALCAM

Genomic Locationfor ALCAM

Proteinsfor ALCAM

Protein Domains/Familiesfor ALCAM

Gene Functionfor ALCAM

Pathways & Interactionsfor ALCAM

Drugs & Compoundsfor ALCAM

Transcriptsfor ALCAM

Expression for ALCAM

Orthologsfor ALCAM

Paralogsfor ALCAM

SNPs/Variantsfor ALCAM

Disorders & Mutationsfor ALCAM

Medical Newsfor ALCAM

Publicationsfor ALCAM

Search for ALCAM

Genome Databases showing ALCAM

Other Databases showing ALCAM

Specialized Databases showing ALCAM

Licensable Technologiesfor ALCAM

Servicesfor ALCAM

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ALCAM

Summaries
for ALCAM

Genomic Location
for ALCAM

Proteins
for ALCAM

Protein Domains/
Families
for ALCAM

Gene Function
for ALCAM

Pathways & Interactions
for ALCAM

Drugs & Compounds
for ALCAM

Transcripts
for ALCAM

Expression
for ALCAM

Orthologs
for ALCAM

Paralogs
for ALCAM

SNPs/Variants
for ALCAM

Disorders & Mutations
for ALCAM

Medical News
for ALCAM

Publications
for ALCAM

Licensable Technologies
for ALCAM

Services
for ALCAM