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Aliases for ALCAM Gene

Aliases for ALCAM Gene

  • Activated Leukocyte Cell Adhesion Molecule 2 3 4 5
  • CD166 Antigen 3 4
  • MEMD 3 4
  • Activated Leucocyte Cell Adhesion Molecule 2
  • CD166 3

External Ids for ALCAM Gene

Previous GeneCards Identifiers for ALCAM Gene

  • GC03P101874
  • GC03P104601
  • GC03P106366
  • GC03P106406
  • GC03P106407
  • GC03P106568
  • GC03P105085
  • GC03P102460

Summaries for ALCAM Gene

Entrez Gene Summary for ALCAM Gene

  • This gene encodes activated leukocyte cell adhesion molecule (ALCAM), also known as CD166 (cluster of differentiation 166), which is a member of a subfamily of immunoglobulin receptors with five immunoglobulin-like domains (VVC2C2C2) in the extracellular domain. This protein binds to T-cell differentiation antigene CD6, and is implicated in the processes of cell adhesion and migration. Multiple alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Aug 2011]

GeneCards Summary for ALCAM Gene

ALCAM (Activated Leukocyte Cell Adhesion Molecule) is a Protein Coding gene. Diseases associated with ALCAM include Appendix Adenocarcinoma and Small Intestinal Adenocarcinoma. Among its related pathways are Developmental Biology and Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. GO annotations related to this gene include receptor binding. An important paralog of this gene is MIR6756.

UniProtKB/Swiss-Prot for ALCAM Gene

  • Cell adhesion molecule that mediates both heterotypic cell-cell contacts via its interaction with CD6, as well as homotypic cell-cell contacts (PubMed:7760007, PubMed:15496415, PubMed:15048703, PubMed:16352806, PubMed:23169771, PubMed:24945728). Promotes T-cell activation and proliferation via its interactions with CD6 (PubMed:15048703, PubMed:16352806, PubMed:24945728). Contributes to the formation and maturation of the immunological synapse via its interactions with CD6 (PubMed:15294938, PubMed:16352806). Mediates homotypic interactions with cells that express ALCAM (PubMed:15496415, PubMed:16352806). Required for normal hematopoietic stem cell engraftment in the bone marrow (PubMed:24740813). Mediates attachment of dendritic cells onto endothelial cells via homotypic interaction (PubMed:23169771). Inhibits endothelial cell migration and promotes endothelial tube formation via homotypic interactions (PubMed:15496415, PubMed:23169771). Required for normal organization of the lymph vessel network. Required for normal hematopoietic stem cell engraftment in the bone marrow. Plays a role in hematopoiesis; required for normal numbers of hematopoietic stem cells in bone marrow. Promotes in vitro osteoblast proliferation and differentiation (By similarity). Promotes neurite extension, axon growth and axon guidance; axons grow preferentially on surfaces that contain ALCAM. Mediates outgrowth and pathfinding for retinal ganglion cell axons (By similarity).

  • Isoform 3: Inhibits activities of membrane-bound isoforms by competing for the same interaction partners. Inhibits cell attachment via homotypic interactions. Promotes endothelial cell migration. Inhibits endothelial cell tube formation.

Gene Wiki entry for ALCAM Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ALCAM Gene

Genomics for ALCAM Gene

Regulatory Elements for ALCAM Gene

Enhancers for ALCAM Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F105385 1.2 Ensembl ENCODE 15.1 +20.5 20494 3.6 ATF1 ARID4B DMAP1 SP5 KAT8 MIER3 ATF4 ETV4 RCOR2 KDM1A ALCAM GC03M105407
GH03F105361 1.5 FANTOM5 ENCODE 5.8 -0.5 -514 9.7 WRNIP1 ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF207 FOS SP3 SP5 ALCAM GC03P105365
GH03F104907 0.9 Ensembl ENCODE 7.2 -457.9 -457869 3.6 CTCF ZNF654 JUN CEBPB EP300 RAD21 JUND SMARCA4 POLR2A SMC3 ALCAM GC03M104926 PIR54392
GH03F105156 0.4 ENCODE 12.4 -209.6 -209632 2.1 POU5F1 ALCAM PIR44849 GC03P105138
GH03F105612 0.9 ENCODE 5.4 +247.2 247164 2.4 HDAC1 PKNOX1 CBX3 ATF1 ARNT TBL1XR1 CHAMP1 ELK1 GATA2 SIRT6 ALCAM PIR53318 GC03P105504
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ALCAM on UCSC Golden Path with GeneCards custom track

Promoters for ALCAM Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001850490 1287 5601 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 YY1 ZNF143 ZNF207 FOS SP3

Transcription factor binding sites by QIAGEN in the ALCAM gene promoter:

Genomic Location for ALCAM Gene

Chromosome:
3
Start:
105,366,713 bp from pter
End:
105,576,913 bp from pter
Size:
210,201 bases
Orientation:
Plus strand

Genomic View for ALCAM Gene

Genes around ALCAM on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ALCAM Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ALCAM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ALCAM Gene

Proteins for ALCAM Gene

  • Protein details for ALCAM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13740-CD166_HUMAN
    Recommended name:
    CD166 antigen
    Protein Accession:
    Q13740
    Secondary Accessions:
    • B2RNS3
    • B4DTU0
    • O60892
    • Q1HGM8
    • Q1HGM9
    • Q6PEY4
    • Q6ZS95

    Protein attributes for ALCAM Gene

    Size:
    583 amino acids
    Molecular mass:
    65102 Da
    Quaternary structure:
    • Homodimer (PubMed:7760007, PubMed:16352806, PubMed:15048703, PubMed:26146185). Interacts (via extracellular domain) with CD6 (via extracellular domain) (PubMed:7760007, PubMed:8823162, PubMed:15048703, PubMed:16914752, PubMed:24945728, PubMed:26146185). Homodimerization and interaction with CD6 involve the same region and cannot occur simultaneously. The affinity for CD6 is much higher than the affinity for self-association (PubMed:15048703). Interacts (via glycosylated extracellular domain) with LGALS1 and LGALS3 (PubMed:24945728). Interaction with LGALS1 or LGALS3 inhibits interaction with CD6 (PubMed:24945728).

    Three dimensional structures from OCA and Proteopedia for ALCAM Gene

    Alternative splice isoforms for ALCAM Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ALCAM Gene

Post-translational modifications for ALCAM Gene

  • Glycosylated.
  • Glycosylation at Asn 91, Asn 95, Asn 167, Asn 265, Asn 306, Asn 361, Asn 457, Asn 466, Asn 480, and Asn 499
  • Modification sites at PhosphoSitePlus

Other Protein References for ALCAM Gene

Antibody Products

No data available for DME Specific Peptides for ALCAM Gene

Domains & Families for ALCAM Gene

Graphical View of Domain Structure for InterPro Entry

Q13740

UniProtKB/Swiss-Prot:

CD166_HUMAN :
  • The CD6 binding site is located in the N-terminal Ig-like domain.
Domain:
  • The CD6 binding site is located in the N-terminal Ig-like domain.
  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 2 Ig-like V-type (immunoglobulin-like) domains.
genes like me logo Genes that share domains with ALCAM: view

Function for ALCAM Gene

Molecular function for ALCAM Gene

GENATLAS Biochemistry:
activated leukocyte-cell adhesion molecule,CD6 ligand,homologous to rat KG-CAM,chicken neural adhesion molecule
UniProtKB/Swiss-Prot Function:
Cell adhesion molecule that mediates both heterotypic cell-cell contacts via its interaction with CD6, as well as homotypic cell-cell contacts (PubMed:7760007, PubMed:15496415, PubMed:15048703, PubMed:16352806, PubMed:23169771, PubMed:24945728). Promotes T-cell activation and proliferation via its interactions with CD6 (PubMed:15048703, PubMed:16352806, PubMed:24945728). Contributes to the formation and maturation of the immunological synapse via its interactions with CD6 (PubMed:15294938, PubMed:16352806). Mediates homotypic interactions with cells that express ALCAM (PubMed:15496415, PubMed:16352806). Required for normal hematopoietic stem cell engraftment in the bone marrow (PubMed:24740813). Mediates attachment of dendritic cells onto endothelial cells via homotypic interaction (PubMed:23169771). Inhibits endothelial cell migration and promotes endothelial tube formation via homotypic interactions (PubMed:15496415, PubMed:23169771). Required for normal organization of the lymph vessel network. Required for normal hematopoietic stem cell engraftment in the bone marrow. Plays a role in hematopoiesis; required for normal numbers of hematopoietic stem cells in bone marrow. Promotes in vitro osteoblast proliferation and differentiation (By similarity). Promotes neurite extension, axon growth and axon guidance; axons grow preferentially on surfaces that contain ALCAM. Mediates outgrowth and pathfinding for retinal ganglion cell axons (By similarity).
UniProtKB/Swiss-Prot Function:
Isoform 3: Inhibits activities of membrane-bound isoforms by competing for the same interaction partners. Inhibits cell attachment via homotypic interactions. Promotes endothelial cell migration. Inhibits endothelial cell tube formation.
UniProtKB/Swiss-Prot Induction:
Up-regulated by TNF and IFNG (at protein level).

Gene Ontology (GO) - Molecular Function for ALCAM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding TAS 7760007
GO:0005515 protein binding IPI 24945728
genes like me logo Genes that share ontologies with ALCAM: view
genes like me logo Genes that share phenotypes with ALCAM: view

Animal Models for ALCAM Gene

MGI Knock Outs for ALCAM:

Animal Model Products

  • Taconic Biosciences Mouse Models for ALCAM

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ALCAM Gene

Localization for ALCAM Gene

Subcellular locations from UniProtKB/Swiss-Prot for ALCAM Gene

Cell membrane; Single-pass type I membrane protein. Cell projection, axon. Cell projection, dendrite. Note=Detected at the immunological synapse, i.e, at the contact zone between antigen-presenting dendritic cells and T-cells (PubMed:15294938, PubMed:16352806). Colocalizes with CD6 and the TCR/CD3 complex at the immunological synapse (PubMed:15294938). {ECO:0000269 PubMed:15294938, ECO:0000269 PubMed:16352806}.
Isoform 3: Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ALCAM gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytoskeleton 2
peroxisome 2
cytosol 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for ALCAM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001772 immunological synapse IDA 15294938
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane ISS --
GO:0005925 focal adhesion IDA 21423176
genes like me logo Genes that share ontologies with ALCAM: view

Pathways & Interactions for ALCAM Gene

genes like me logo Genes that share pathways with ALCAM: view

Gene Ontology (GO) - Biological Process for ALCAM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
GO:0007155 cell adhesion ISS,TAS --
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IMP 16352806
GO:0007165 signal transduction TAS 7760007
genes like me logo Genes that share ontologies with ALCAM: view

No data available for SIGNOR curated interactions for ALCAM Gene

Drugs & Compounds for ALCAM Gene

(3) Drugs for ALCAM Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with ALCAM: view

Transcripts for ALCAM Gene

Unigene Clusters for ALCAM Gene

Activated leukocyte cell adhesion molecule:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ALCAM Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b
SP1: - - - -
SP2: - - - - -
SP3: - -
SP4: - - -
SP5:
SP6:
SP7:

Relevant External Links for ALCAM Gene

GeneLoc Exon Structure for
ALCAM
ECgene alternative splicing isoforms for
ALCAM

Expression for ALCAM Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ALCAM Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ALCAM Gene

This gene is overexpressed in Nasal epithelium (19.8) and Cerebral cortex (19.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ALCAM Gene



NURSA nuclear receptor signaling pathways regulating expression of ALCAM Gene:

ALCAM

SOURCE GeneReport for Unigene cluster for ALCAM Gene:

Hs.591293

mRNA Expression by UniProt/SwissProt for ALCAM Gene:

Q13740-CD166_HUMAN
Tissue specificity: Detected on hematopoietic stem cells derived from umbilical cord blood (PubMed:24740813). Detected on lymph vessel endothelial cells, skin and tonsil (PubMed:23169771). Detected on peripheral blood monocytes (PubMed:15048703). Detected on monocyte-derived dendritic cells (at protein level) (PubMed:16352806). Detected at low levels in spleen, placenta, liver (PubMed:9502422). Expressed by activated T-cells, B-cells, monocytes and thymic epithelial cells (PubMed:7760007). Isoform 1 and isoform 3 are detected in vein and artery endothelial cells, astrocytes, keratinocytes and artery smooth muscle cells (PubMed:15496415). Expressed by neurons in the brain. Restricted expression in tumor cell lines. Detected in highly metastasizing melanoma cell lines (PubMed:9502422).
genes like me logo Genes that share expression patterns with ALCAM: view

Primer Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for ALCAM Gene

Orthologs for ALCAM Gene

This gene was present in the common ancestor of chordates.

Orthologs for ALCAM Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ALCAM 34 35
  • 99.37 (n)
dog
(Canis familiaris)
Mammalia ALCAM 34 35
  • 93.48 (n)
cow
(Bos Taurus)
Mammalia ALCAM 34 35
  • 93.42 (n)
rat
(Rattus norvegicus)
Mammalia Alcam 34
  • 89.65 (n)
mouse
(Mus musculus)
Mammalia Alcam 34 16 35
  • 89.25 (n)
oppossum
(Monodelphis domestica)
Mammalia ALCAM 35
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ALCAM 35
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves ALCAM 34 35
  • 76.87 (n)
lizard
(Anolis carolinensis)
Reptilia ALCAM 35
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia alcam 34
  • 63.59 (n)
Str.15872 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.1643 34
zebrafish
(Danio rerio)
Actinopterygii alcama 34 35
  • 49.4 (n)
alcamb 35
  • 37 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 18 (a)
OneToMany
Species where no ortholog for ALCAM was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ALCAM Gene

ENSEMBL:
Gene Tree for ALCAM (if available)
TreeFam:
Gene Tree for ALCAM (if available)

Paralogs for ALCAM Gene

Paralogs for ALCAM Gene

(2) SIMAP similar genes for ALCAM Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ALCAM: view

Variants for ALCAM Gene

Sequence variations from dbSNP and Humsavar for ALCAM Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs10049426 -- 105,420,589(+) ATAAT(A/G)TCTTC intron-variant
rs1017913 -- 105,519,771(-) AACAT(A/C)GTGGA intron-variant
rs1017914 -- 105,519,115(-) TGAAT(A/G)TCTAT intron-variant
rs1017915 -- 105,502,572(-) GTGCC(C/T)TGCTC intron-variant
rs1020110 -- 105,413,388(-) AGAAA(A/C)TGTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ALCAM Gene

Variant ID Type Subtype PubMed ID
nsv829651 CNV loss 17160897
nsv829650 CNV gain 17160897
nsv591240 CNV gain 21841781
nsv525071 CNV gain 19592680
nsv509844 OTHER sequence alteration 20534489
nsv475851 CNV novel sequence insertion 20440878
nsv460811 CNV gain 19166990
nsv1012669 CNV gain 25217958
nsv1008291 CNV loss 25217958
esv3568949 CNV loss 25503493
esv3568948 CNV loss 25503493

Variation tolerance for ALCAM Gene

Residual Variation Intolerance Score: 51.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.14; 75.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ALCAM Gene

Human Gene Mutation Database (HGMD)
ALCAM
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ALCAM

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ALCAM Gene

Disorders for ALCAM Gene

MalaCards: The human disease database

(3) MalaCards diseases for ALCAM Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
appendix adenocarcinoma
  • adenocarcinoma of appendix
small intestinal adenocarcinoma
  • adenocarcinoma of small bowel
malignant melanoma, somatic
  • dysplastic nevus syndrome
- elite association - COSMIC cancer census association via MalaCards
Search ALCAM in MalaCards View complete list of genes associated with diseases

Relevant External Links for ALCAM

Genetic Association Database (GAD)
ALCAM
Human Genome Epidemiology (HuGE) Navigator
ALCAM
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ALCAM
genes like me logo Genes that share disorders with ALCAM: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ALCAM Gene

Publications for ALCAM Gene

  1. Cloning, mapping, and characterization of activated leukocyte-cell adhesion molecule (ALCAM), a CD6 ligand. (PMID: 7760007) Bowen M.A. … Aruffo A. (J. Exp. Med. 1995) 2 3 4 22 64
  2. Genetic polymorphisms of adhesion molecules and kidney transplant survival. (PMID: 20220571) Heinold A. … Tran T.H. (Transplantation 2010) 3 22 46 64
  3. Long-term engagement of CD6 and ALCAM is essential for T-cell proliferation induced by dendritic cells. (PMID: 16352806) Zimmerman A.W. … Figdor C.G. (Blood 2006) 3 4 22 64
  4. Molecular isolation and characterization of a soluble isoform of activated leukocyte cell adhesion molecule that modulates endothelial cell function. (PMID: 15496415) Ikeda K. … Quertermous T. (J. Biol. Chem. 2004) 3 4 22 64
  5. MEMD, a new cell adhesion molecule in metastasizing human melanoma cell lines, is identical to ALCAM (activated leukocyte cell adhesion molecule). (PMID: 9502422) Degen W.G. … Swart G.W. (Am. J. Pathol. 1998) 3 4 22 64

Products for ALCAM Gene

Sources for ALCAM Gene

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