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Aliases for ALB Gene

Aliases for ALB Gene

  • Albumin 2 3
  • Cell Growth Inhibiting Protein 42 3
  • Growth-Inhibiting Protein 20 3
  • Albumin (32 AA) 3
  • Albumin (AA 34) 3
  • Serum Albumin 3
  • PRO0883 3
  • PRO0903 3
  • PRO1341 3
  • ANALBA 3
  • FDAH 3

External Ids for ALB Gene

Summaries for ALB Gene

Entrez Gene Summary for ALB Gene

  • Albumin is a soluble, monomeric protein which comprises about one-half of the blood serum protein. Albumin functions primarily as a carrier protein for steroids, fatty acids, and thyroid hormones and plays a role in stabilizing extracellular fluid volume. Albumin is a globular unglycosylated serum protein of molecular weight 65,000. Albumin is synthesized in the liver as preproalbumin which has an N-terminal peptide that is removed before the nascent protein is released from the rough endoplasmic reticulum. The product, proalbumin, is in turn cleaved in the Golgi vesicles to produce the secreted albumin. [provided by RefSeq, Jul 2008]

GeneCards Summary for ALB Gene

ALB (Albumin) is a Protein Coding gene. Diseases associated with ALB include analbuminemia and dysalbuminemic hyperthyroxinemia. Among its related pathways are Hemostasis and Hemostasis. GO annotations related to this gene include enzyme binding and drug binding. An important paralog of this gene is AFM.

UniProtKB/Swiss-Prot for ALB Gene

  • Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.

Gene Wiki entry for ALB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ALB Gene

Genomics for ALB Gene

Genomic Location for ALB Gene

Start:
73,397,114 bp from pter
End:
73,421,412 bp from pter
Size:
24,299 bases
Orientation:
Plus strand

Genomic View for ALB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ALB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ALB Gene

Regulatory Elements for ALB Gene

Proteins for ALB Gene

  • Protein details for ALB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P02768-ALBU_HUMAN
    Recommended name:
    Serum albumin
    Protein Accession:
    P02768
    Secondary Accessions:
    • E7ESS9
    • O95574
    • P04277
    • Q13140
    • Q645G4
    • Q68DN5
    • Q6UXK4
    • Q86YG0
    • Q8IUK7
    • Q9P157
    • Q9P1I7
    • Q9UHS3
    • Q9UJZ0

    Protein attributes for ALB Gene

    Size:
    609 amino acids
    Molecular mass:
    69367 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF22034.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAF69644.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAG35503.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ALB Gene

    Alternative splice isoforms for ALB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ALB Gene

Proteomics data for ALB Gene at MOPED

Post-translational modifications for ALB Gene

  • Acetylated on Lys-223 by acetylsalicylic acid
  • Glycated in diabetic patients
  • Kenitra variant is partially O-glycosylated at Thr-620. It has two new disulfide bonds Cys-600 to Cys-602 and Cys-601 to Cys-606
  • Phosphorylation sites are present in the extracellular medium
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys229
  • Glycosylation at Lys36, Lys75, Lys161, Lys186, Lys223, Lys249, Lys257, Lys300, Lys305, Lys337, Lys341, Asn342, Lys347, Lys375, Lys402, Lys437, Thr444, Lys463, Lys468, Asp518, Lys549, Lys558, Lys560, Lys569, and Lys597

Other Protein References for ALB Gene

No data available for DME Specific Peptides for ALB Gene

Domains for ALB Gene

Suggested Antigen Peptide Sequences for ALB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P02768

UniProtKB/Swiss-Prot:

ALBU_HUMAN
Domain:
  • Contains 3 albumin domains.:
    • P02768
Family:
  • Belongs to the ALB/AFP/VDB family.:
    • P02768
genes like me logo Genes that share domains with ALB: view

No data available for Gene Families for ALB Gene

Function for ALB Gene

Molecular function for ALB Gene

GENATLAS Biochemistry: albumin,putative down-regulated c-Myc target gene,
UniProtKB/Swiss-Prot Function: Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.

Gene Ontology (GO) - Molecular Function for ALB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IDA 16405401
GO:0005504 fatty acid binding NAS 9731778
GO:0005507 copper ion binding NAS 14726550
GO:0005515 protein binding IPI 16099937
GO:0008144 drug binding NAS 10940303
genes like me logo Genes that share ontologies with ALB: view
genes like me logo Genes that share phenotypes with ALB: view

Animal Models for ALB Gene

MGI Knock Outs for ALB:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for ALB Gene

Localization for ALB Gene

Subcellular locations from UniProtKB/Swiss-Prot for ALB Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ALB Gene COMPARTMENTS Subcellular localization image for ALB gene
Compartment Confidence
extracellular 5
cytoskeleton 3
cytosol 3
endoplasmic reticulum 3
mitochondrion 3
nucleus 3
plasma membrane 3
chloroplast 2
endosome 2
golgi apparatus 2
lysosome 2
peroxisome 2
vacuole 2

Gene Ontology (GO) - Cellular Components for ALB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005604 basement membrane IEA --
GO:0005615 extracellular space IDA 19996109
GO:0005634 nucleus IDA 21630459
GO:0005737 cytoplasm --
genes like me logo Genes that share ontologies with ALB: view

Pathways for ALB Gene

genes like me logo Genes that share pathways with ALB: view

Pathways by source for ALB Gene

Gene Ontology (GO) - Biological Process for ALB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001895 retina homeostasis IEP 23580065
GO:0002576 platelet degranulation TAS --
GO:0006810 transport TAS 12617161
GO:0006898 receptor-mediated endocytosis TAS --
GO:0007584 response to nutrient IEA --
genes like me logo Genes that share ontologies with ALB: view

Compounds for ALB Gene

(10) HMDB Compounds for ALB Gene

Compound Synonyms Cas Number PubMed IDs
Bilirubin
  • (4Z,15Z)-Bilirubin IXa
635-65-4
Bismuth
  • Bi
7440-69-9
Chlorpheniramine
  • Chlor-trimeton
113-92-8
Estrone
  • (+)-Estrone
53-16-7
Estrone sulfate
  • Conestoral
481-97-0

(140) Novoseek inferred chemical compound relationships for ALB Gene

Compound -log(P) Hits PubMed IDs
creatinine 90.6 371
fibrinogen 83.7 358
cholesterol 79.9 256
rhsa 78.5 47
dansylsarcosine 78.2 25
genes like me logo Genes that share compounds with ALB: view

Transcripts for ALB Gene

Unigene Clusters for ALB Gene

Albumin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ALB Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^ 14a ·
SP1: - - -
SP2: - - - - - - - - - - -
SP3: - - - - - - - - - - - -
SP4: - - - - - - - - - - - -
SP5: - - - - - - -
SP6: -
SP7: - - -
SP8: - -
SP9:
SP10:

ExUns: 14b ^ 15 ^ 16a · 16b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for ALB Gene

GeneLoc Exon Structure for
ALB
ECgene alternative splicing isoforms for
ALB

Expression for ALB Gene

mRNA expression in normal human tissues for ALB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ALB Gene

This gene is overexpressed in Liver (51.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ALB Gene

SOURCE GeneReport for Unigene cluster for ALB Gene Hs.418167

mRNA Expression by UniProt/SwissProt for ALB Gene

P02768-ALBU_HUMAN
Tissue specificity: Plasma
genes like me logo Genes that share expressions with ALB: view

Orthologs for ALB Gene

This gene was present in the common ancestor of chordates.

Orthologs for ALB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ALB 35
  • 99.34 (n)
  • 98.85 (a)
ALB 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ALB 35
  • 82.32 (n)
  • 76.44 (a)
ALB 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ALB 35
  • 82.43 (n)
  • 80.4 (a)
ALB 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Alb 35
  • 77.08 (n)
  • 72.37 (a)
Alb 16
Alb 36
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ALB 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ALB 36
  • 59 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Alb 35
  • 76.26 (n)
  • 73.52 (a)
chicken
(Gallus gallus)
Aves ALB 35
  • 60.37 (n)
  • 47.95 (a)
ALB 36
  • 46 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cars2 35
  • 54.04 (n)
  • 39.87 (a)
Species with no ortholog for ALB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ALB Gene

ENSEMBL:
Gene Tree for ALB (if available)
TreeFam:
Gene Tree for ALB (if available)

Paralogs for ALB Gene

Paralogs for ALB Gene

Selected SIMAP similar genes for ALB Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with ALB: view

Variants for ALB Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for ALB Gene

P02768-ALBU_HUMAN
A variant structure of albumin could lead to increased binding of zinc resulting in an asymptomatic augmentation of zinc concentration in the blood. The sequence shown is that of variant albumin A

Sequence variations from dbSNP and Humsavar for ALB Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs667 -- 73,414,548(-) AGGCG(A/G)AGGTT intron-variant
rs4076 -- 73,419,835(+) CTGTT(A/G)AATGT intron-variant
rs962004 -- 73,419,522(+) GAGCT(C/G/T)GTGAA reference, synonymous-codon
rs962005 -- 73,419,850(+) AATGC(A/C)TGTTC intron-variant
rs1063469 - 73,418,127(+) ATGAG(A/G)AAACG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ALB Gene

Variant ID Type Subtype PubMed ID
nsv879490 CNV Gain 21882294
dgv956e199 CNV Deletion 23128226
esv274665 CNV Insertion 20981092
nsv879491 CNV Loss 21882294

Relevant External Links for ALB Gene

HapMap Linkage Disequilibrium report
ALB
Human Gene Mutation Database (HGMD)
ALB
Locus Specific Mutation Databases (LSDB)
ALB

Disorders for ALB Gene

(1) OMIM Diseases for ALB Gene (103600)

UniProtKB/Swiss-Prot

ALBU_HUMAN
  • Hyperthyroxinemia, familial dysalbuminemic (FDAH) [MIM:615999]: A disorder characterized by abnormally elevated levels of total serum thyroxine (T4) in euthyroid patients. It is due to abnormal serum albumin that binds T4 with enhanced affinity. {ECO:0000269 PubMed:7852505, ECO:0000269 PubMed:8048949, ECO:0000269 PubMed:9329347, ECO:0000269 PubMed:9589637}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Analbuminemia (ANALBA) [MIM:616000]: A rare autosomal recessive disorder manifested by the presence of a very low amount of circulating serum albumin. Affected individuals manifest mild edema, hypotension, fatigue, and, occasionally, lower body lipodystrophy (mainly in adult females). The most common biochemical finding is hyperlipidemia, with a significant increase in the total and LDL cholesterol concentrations, but normal concentrations of HDL cholesterol and triglycerides. {ECO:0000269 PubMed:8134387}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(96) Novoseek inferred disease relationships for ALB Gene

Disease -log(P) Hits PubMed IDs
microalbuminuria 94.9 233
albuminuria 92.5 138
hypoalbuminemia 90.4 149
diabetic nephropathies 89.2 129
renal disease 87 161

Relevant External Links for ALB

Genetic Association Database (GAD)
ALB
Human Genome Epidemiology (HuGE) Navigator
ALB
genes like me logo Genes that share disorders with ALB: view

Publications for ALB Gene

  1. Two alloalbumins with identical electrophoretic mobility are produced by differently charged amino acid substitutions. (PMID: 1347703) Minchiotti L. … Porta F. (Biochim. Biophys. Acta 1992) 3 4 23
  2. Genetic variants of serum albumin in Americans and Japanese. (PMID: 1946412) Madison J. … Putnam F.W. (Proc. Natl. Acad. Sci. U.S.A. 1991) 3 4 23
  3. Protein and DNA sequence analysis of a 'private' genetic variant: albumin Ortonovo (Glu-505-->Lys). (PMID: 7902134) Galliano M. … Putnam F.W. (Biochim. Biophys. Acta 1993) 3 4 23
  4. Crystal structure of human serum albumin at 2.5-A resolution. (PMID: 10388840) Sugio S. … Kobayashi K. (Protein Eng. 1999) 3 4 23
  5. A nucleotide insertion and frameshift cause albumin Kenitra, an extended and O-glycosylated mutant of human serum albumin with two additional disulfide bridges. (PMID: 11168369) Minchiotti L. … Galliano M. (Eur. J. Biochem. 2001) 3 4 23

Products for ALB Gene

Sources for ALB Gene

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