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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ALB Gene

protein-coding   GIFtS: 70
GCID: GC04P074259

Albumin

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
albumin1 2     Albumin (AA 34)2
PRO08832     Cell Growth Inhibiting Protein 422
PRO09032     Growth-Inhibiting Protein 202
PRO13412     Serum Albumin2
Albumin (32 AA)2     

External Ids:    HGNC: 3991   Entrez Gene: 2132   Ensembl: ENSG000001636317   OMIM: 1036005   UniProtKB: P027683   

Export aliases for ALB gene to outside databases

Previous GC identifers: GC04P074509 GC04P074670 GC04P074736 GC04P074635 GC04P070083


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ALB Gene:
Albumin is a soluble, monomeric protein which comprises about one-half of the blood serum protein. Albumin
functions primarily as a carrier protein for steroids, fatty acids, and thyroid hormones and plays a role in
stabilizing extracellular fluid volume. Albumin is a globular unglycosylated serum protein of molecular weight
65,000. Albumin is synthesized in the liver as preproalbumin which has an N-terminal peptide that is removed
before the nascent protein is released from the rough endoplasmic reticulum. The product, proalbumin, is in turn
cleaved in the Golgi vesicles to produce the secreted albumin. (provided by RefSeq, Jul 2008)

GeneCards Summary for ALB Gene: 
ALB (albumin) is a protein-coding gene. Diseases associated with ALB include hepatorenal syndrome, and dysalbuminemic hyperthyroxinemia, and among its related super-pathways are Lipoprotein metabolism and Response to elevated platelet cytosolic Ca2+. GO annotations related to this gene include drug binding and enzyme binding. An important paralog of this gene is AFM.

UniProtKB/Swiss-Prot: ALBU_HUMAN, P02768
Function: Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+),
fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure
of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc

Gene Wiki entry for ALB (Serum albumin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NT_022778.16  NC_018915.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ALB gene promoter:
         STAT5B   TBP   STAT1   STAT4   STAT1beta   STAT5A   STAT1alpha   C/EBPalpha   STAT2   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 15): ALB promoter sequence
   Search SABiosciences Chromatin IP Primers for ALB

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ALB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q13.3   Ensembl cytogenetic band:  4q13.3   HGNC cytogenetic band: 4q13.3

ALB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ALB gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P074259:  view genomic region     (about GC identifiers)

Start:
74,262,831 bp from pter      End:
74,287,129 bp from pter
Size:
24,299 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ALBU_HUMAN, P02768 (See protein sequence)
Recommended Name: Serum albumin precursor  
Size: 609 amino acids; 69367 Da
Subcellular location: Secreted
Caution: A peptide arising from positions 166 to 174 was originally (PubMed:3087352 and PubMed:2437111) termed
neurotensin-related peptide (NRP) or kinetensin and was thought to regulate fat digestion, lipid absorption, and
blood flow
Sequence caution: Sequence=AAF22034.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAF69644.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAG35503.1;
Type=Erroneous initiation; Note=Translation N-terminally extended;
6/77 PDB 3D structures from and Proteopedia for ALB (see all 77):
1AO6 (3D)        1BJ5 (3D)        1BKE (3D)        1BM0 (3D)        1E78 (3D)        1E7A (3D)    
Secondary accessions: O95574 P04277 Q13140 Q645G4 Q68DN5 Q6UXK4 Q86YG0 Q9P157 Q9P1I7 Q9UHS3
Q9UJZ0
Alternative splicing: 2 isoforms:  P02768-1   P02768-2   

Explore the universe of human proteins at neXtProt for ALB: NX_P02768

Explore proteomics data for ALB at MOPED 

Post-translational modifications:

  • UniProtKB: Kenitra variant is partially O-glycosylated at Thr-620. It has two new disulfide bonds Cys-600 to Cys-602 and
    Cys-601 to Cys-606
  • UniProtKB: Glycated in diabetic patients
  • UniProtKB: Phosphorylation sites are present in the extracellular medium
  • UniProtKB: Acetylated on Lys-223 by acetylsalicylic acid
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P02768

  • ALB Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ALB Protein Expression
    REFSEQ proteins: NP_000468.1  
    ENSEMBL proteins: 
     ENSP00000392541   ENSP00000295897   ENSP00000401820   ENSP00000423727   ENSP00000421027  
     ENSP00000422784   ENSP00000384695   ENSP00000426179  
    Reactome Protein details: P02768
    Human Recombinant Protein Products for ALB: 
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    OriGene MassSpec for ALB 
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    Novus Biologicals ALB Proteins
    Novus Biologicals ALB Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for ALB
    Cloud-Clone Corp. Proteins for ALB 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005604basement membrane IEA--
    GO:0005615extracellular space IDA19996109
    GO:0005737cytoplasm ----
    GO:0031093platelet alpha granule lumen TAS--

    ALB for ontologies           About GeneDecksing



    ALB Antibody Products: 
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    Assay Products for ALB: 
    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. CLIAs for ALB


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro protein domains:
     IPR020858 Serum_albumin-like
     IPR000264 ALB/AFP/VDB
     IPR014760 Serum_albumin_N
     IPR020857 Serum_albumin_CS
     IPR021177 Serum_albumin/AFP

    Graphical View of Domain Structure for InterPro Entry P02768

    ProtoNet protein and cluster: P02768

    1 Blocks protein domain: IPB000264 Serum albumin family

    UniProtKB/Swiss-Prot: ALBU_HUMAN, P02768
    Similarity: Belongs to the ALB/AFP/VDB family
    Similarity: Contains 3 albumin domains


    ALB for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ALBU_HUMAN, P02768
    Function: Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+),
    fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure
    of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc

         Genatlas biochemistry entry for ALB:
    albumin,putative down-regulated c-Myc target gene,

         Gene Ontology (GO): 5/13 molecular function terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IDA16405401
    GO:0005504fatty acid binding NAS9731778
    GO:0005507copper ion binding NAS14726550
    GO:0005515protein binding IPI16099937
    GO:0008144drug binding NAS10940303
         
    ALB for ontologies           About GeneDecksing


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Alb):
     digestive/alimentary  homeostasis/metabolism  liver/biliary system  mortality/aging  normal 
     renal/urinary system  tumorigenesis 

    ALB for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for ALB: Albtm1Lex Afp/AlbAfp/tm1.1Brts

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ALB 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ALB

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ALB 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ALB 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ALB
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ALB
    SwitchGear 3'UTR luciferase reporter plasmidALB 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    OriGene clones in human, mouse for ALB (see all 8)
    OriGene ORF clones in mouse, rat for ALB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ALB (NM_000477)
    Sino Biological Human cDNA Clone for ALB
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ALB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALB
    Sirion Biotech Customized lentivirus for stable overexpression of ALB 
                         Customized lentivirus expression plasmids for stable overexpression of ALB 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALB


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ALB About   (see all 13)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Lipoprotein metabolism
    Lipoprotein metabolism0.57
    Lipid digestion, mobilization, and transport0.56
    HDL-mediated lipid transport0.57
    2Platelet degranulation
    Platelet degranulation 0.94
    Response to elevated platelet cytosolic Ca2+0.94
    3Synthesis of bile acids and bile salts
    Bile acid and bile salt metabolism0.74
    Recycling of bile acids and salts0.35
    4Binding and Uptake of Ligands by Scavenger Receptors
    Binding and Uptake of Ligands by Scavenger Receptors0.63
    Scavenging of Heme from Plasma0.63
    5SLC-mediated transmembrane transport
    SLC-mediated transmembrane transport0.50
    Transmembrane transport of small molecules0.50

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for ALB
        Selected targets of HNF1
    Selected targets of C/EBPalpha


    1 Cell Signaling Technology (CST) Pathway for ALB
        Ca, cAMP and Lipid Signaling

    2 BioSystems Pathways for ALB
        Selenium Pathway
    FOXA2 and FOXA3 transcription factor networks


    5/17        Reactome Pathways for ALB (see all 17)
        Metabolism
    Recycling of bile acids and salts
    Response to elevated platelet cytosolic Ca2+
    Transmembrane transport of small molecules
    SLC-mediated transmembrane transport



    ALB for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ALB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/260 Interacting proteins for ALB (P027682, 3 ENSP000002958974) via UniProtKB, MINT, STRING, and/or I2D (see all 260)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IMMTQ168912, 3, ENSP000003872624MINT-8258723 I2D: score=2 STRING: ENSP00000387262
    PFDN1O609252, 3MINT-8265687 I2D: score=2 
    TK1P041832, 3MINT-8272905 I2D: score=2 
    ENSG00000237112Q9UBS53, ENSP000004112864I2D: score=1 STRING: ENSP00000411286
    ENSG00000206466Q9UBS53I2D: score=1 
    About this table

    Gene Ontology (GO): 5/21 biological process terms (GO ID links to tree view) (see all 21):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002576platelet degranulation TAS--
    GO:0006810transport TAS12617161
    GO:0006950response to stress ----
    GO:0007584response to nutrient IEA--
    GO:0007596blood coagulation TAS--

    ALB for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ALB for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ALB (ALBU)

    10 HMDB Compounds for ALB    About this table
    CompoundSynonyms CAS #PubMed Ids
    Bilirubin(4Z,15Z)-Bilirubin IXa (see all 17)635-65-418498776
    BismuthBi (see all 2)7440-69-9--
    ChlorpheniramineChlor-trimeton (see all 8)113-92-8--
    Estrone(+)-Estrone (see all 7)53-16-7--
    Estrone sulfateConestoral (see all 12)481-97-0--
    Ibuprofenalpha-(4-Isobutylphenyl)propionate (see all 9)15687-27-1--
    Liothyronine3,3',5-Triiodo-L-thyronine (see all 20)6893-02-3--
    Pyridoxine2-Methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine (see all 16)65-23-6--
    Sodium lauryl sulfateAdeka Hope LS 35 (see all 243)151-21-3--
    Testosterone(+)-testosterone (see all 86)58-22-0--

    10/134 DrugBank Compounds for ALB (see all 134)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Sodium lauryl sulfateDodecyl alcohol, hydrogen sulfate, sodium salt (see all 27)151-21-3carrierbinder16457837 16085141 16256620 16256532 11752352 16379295
    CefoperazoneCefoperazono [inn-spanish] (see all 2)62893-19-0carrierother/unknown2311445 2496656 3339510 16379298 8950041
    PhenprocoumonFenprocumone [DCIT] (see all 5)435-97-2carrier--1205658 1642965 4762907 2751413 12543492
    Auranofin-- 34031-32-8carrier--11666224 7925457 2403377 3655788
    CaptoprilCaptoprilum [INN-Latin] (see all 3)62571-86-2carrierother/unknown16469467 8216349 9040098 15093593
    Diflunisal-- 22494-42-4carrier--17132209 11673972 7371361 2751413
    DigitoxinDigitoksin (see all 3)71-63-6carrier--11678517 10774625 10604823 10202961
    Ethacrynic acidEtacrinic acid (see all 6)58-54-8carrier--9275312 3714803 9863950 2792351
    Gadobenate Dimeglumine-- 113662-23-0carrierbinder9055236 16118549 11752352 9406019
    Gadofosveset trisodiumAblavar (see all 4)193901-90-5carriersubstrate16706555 19222207 17625839 17650553

    10/140 Novoseek inferred chemical compound relationships for ALB gene (see all 140)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    creatinine 90.6 3964 10727680 (8), 8831085 (7), 9080259 (7), 17405790 (7) (see all 99)
    fibrinogen 83.7 1545 16703327 (7), 9610611 (7), 11422756 (7), 12969171 (7) (see all 99)
    cholesterol 79.9 2000 15082432 (7), 8524502 (6), 18563300 (6), 17279492 (5) (see all 99)
    rhsa 78.5 72 9167443 (2), 10502345 (2), 18199895 (2), 9688461 (2) (see all 38)
    dansylsarcosine 78.2 30 1382424 (6), 9430764 (3), 8720306 (2), 1706921 (2) (see all 16)
    urea 77.8 659 8366899 (5), 8573919 (4), 17361319 (4), 10666933 (4) (see all 99)
    uric acid 76.4 495 10910618 (5), 10898045 (4), 18442624 (4), 16554340 (3) (see all 99)
    hydroxyethyl starch 76.4 487 10703679 (8), 11515893 (7), 9261899 (6), 10361869 (6) (see all 99)
    glucose 73.8 1576 19349048 (6), 9103700 (6), 8575721 (6), 16920285 (5) (see all 99)
    fructosamine 71.2 212 10326628 (7), 1597333 (5), 8893144 (5), 8502341 (5) (see all 95)

    Search CenterWatch for drugs/clinical trials and news about ALB / ALBU

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ALB gene: 
    NM_000477.5  

    Unigene Clusters for ALB:

    Albumin
    Hs.418167  [show with all ESTs], Hs.592379  [show with all ESTs]
    Unigene Representative Sequences: NM_000477, BX436222
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000441319 ENST00000295897(uc003hgs.4 uc011cbe.2 uc003hgw.4 uc011cbf.2)
    ENST00000510166 ENST00000515133 ENST00000415165 ENST00000514786 ENST00000476441
    ENST00000503124 ENST00000509063 ENST00000401494 ENST00000505649 ENST00000511370
    ENST00000507673 ENST00000484992 ENST00000504043 ENST00000486939 ENST00000508932
    ENST00000495173
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: ALB (NM_000477)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ALB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALB
    Sirion Biotech Customized lentivirus for stable overexpression of ALB 
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ALB
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ALB

    Additional mRNA sequence: X51365.1 

    24/209 DOTS entries (see all 209):

    DT.100864734  DT.98132054  DT.95377482  DT.100746389  DT.87011119  DT.100861910  DT.100746447  DT.100746541 
    DT.91816166  DT.95377906  DT.95376610  DT.100746432  DT.95376706  DT.100844172  DT.95376678  DT.100861974 
    DT.100746557  DT.100746613  DT.95376631  DT.91998425  DT.92056056  DT.98132061  DT.100746529  DT.95376639 

    24/3197 AceView cDNA sequences (see all 3197):

    CB154190 CB137645 AI114852 AA330058 BX445228 BG617320 AW779704 T40728 
    AU120853 T61204 BG569475 BG618550 D11974 CR594508 AL531773 CR617173 
    CB154103 CB154090 AI064742 BX462898 BG568563 BX423747 BX427484 CB117011 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for ALB (see all 10)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b ^ 13 ^ 14a ·
    SP1:                                                              -                             -                       -                                       
    SP2:                                                  -     -     -     -     -     -     -     -     -     -           -                                       
    SP3:                    -     -     -     -     -     -     -     -     -     -                 -                       -                                       
    SP4:                          -     -     -     -     -     -     -     -     -     -           -                       -                                       
    SP5:                                      -     -     -     -     -     -                       -                                                               

    ExUns: 14b ^ 15 ^ 16a · 16b
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for ALB

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ALB expression in normal human tissues (normalized intensities)      ALB embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGAATAAGAG
    ALB Expression
    About this image


    ALB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/26 selected tissues (see all 26) fully expand
     
     Liver (Hepatobiliary System)    fully expand to see all 15 entries
             Mature Hepatocytes Liver Lobule
             Adult liver progenitor cells
             Hepatocyte-like cells ( Functional hepatocyte generation from human embryonic stem...
             Human Hepatocyte (HH)   
     
     Uterus (Reproductive System)    fully expand to see all 3 entries
             uterus, post-menopause ; glandular cells   
             cervix   
     
     Pancreas (Endocrine System)    fully expand to see all 2 entries
             Endocrine progenitors ( Generation of pancreatic progenitor cells from clinical-grade...
             Pancreatic Islet   
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Embryoid bodies ( Two-step protocol for endothelial differentiation by embryoid...
             colon ; endothelial cells   
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             kidney ; cells in tubules   

    See ALB Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ALB

    SOURCE GeneReport for Unigene clusters: Hs.418167 Hs.592379

    UniProtKB/Swiss-Prot: ALBU_HUMAN, P02768
    Tissue specificity: Plasma

        SABiosciences Expression via Pathway-Focused PCR Arrays including ALB: 
              Cell Lineage Identification in human mouse rat
              Terminal Differentiation Markers in human mouse rat
              Oxidative Stress in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for ALB
    OriGene qSTAR qPCR primer pairs in human, mouse for ALB
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ALB
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ALB
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ALB
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ALB gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Alb1 , 5 albumin1, 5 77.1(n)1
    72.49(a)1
      5 (44.70 cM)5
    116571  NM_009654.31  NP_033784.21 
     904608895 
    chicken
    (Gallus gallus)
    Aves ALB1 albumin 60.37(n)
    47.95(a)
      396197  NM_205261.1  NP_990592.1 
    zebrafish
    (Danio rerio)
    Actinopterygii gc6
    group-specific component (vitamin D binding protei...
    20(a)
    1 → many
    5(47282879-47303096)


    ENSEMBL Gene Tree for ALB (if available)
    TreeFam Gene Tree for ALB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ALB gene
    AFM2  GC2  AFP2  
    2 SIMAP similar genes for ALB using alignment to 8 protein entries:     ALBU_HUMAN (see all proteins):
    AFP    AFM

    ALB for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: ALBU_HUMAN, P02768
    Polymorphism: A variant structure of albumin could lead to increased binding of zinc resulting in an asymptomatic
    augmentation of zinc concentration in the blood. The sequence shown is that of variant albumin A


    10/598 SNPs in ALB are shown (see all 598)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0130114
    Familial dysalbuminemic hyperthyroxinemia (FDH)4--see VAR_0130112 L P mis40--------
    VAR_0005144
    Familial dysalbuminemic hyperthyroxinemia (FDH)4--see VAR_0005142 R H mis40--------
    VAR_0130134
    Familial dysalbuminemic hyperthyroxinemia (FDH)4--see VAR_0130132 R P mis40--------
    rs774081631,2
    Cpathogenic174148127(+) TGCACA/GTAAGA 1 -- spd10--------
    rs778923781,2
    Cpathogenic174150480(+) ATCACC/TTGTAA 2 P L mis10--------
    rs773353741,2
    Cpathogenic174155714(+) TTTTTA/G/TGGGCA 1 -- spa11CSA 1
    rs750026281,2
    Cpathogenic174155727(+) AGCTCA/C/GCCTGA 3 H P R mis10--------
    rs792280411,2
    Cpathogenic174163355(+) TTGCCA/GAGGAG 2 K E mis10--------
    rs762420871,2
    Cuntested174157309(+) TAAGGA/G/TTGTTT 3 D G V mis10--------
    rs782840521,2,4
    C,Funtested174163244(+) AGCTCG/ATGAAA 2 /M /V mis11Minor allele frequency- A:0.00NA 4548

    HapMap Linkage Disequilibrium report for ALB (74262831 - 74287129 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ALB:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv956e199CNV Deletion23128226
    esv274665CNV Insertion20981092
    nsv879491CNV Loss21882294
    nsv879490CNV Gain21882294


    Human Gene Mutation Database (HGMD): ALB

    Locus Specific Mutation Databases (LSDB): ALB
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ALB
    DNA2.0 Custom Variant and Variant Library Synthesis for ALB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 103600   
    OMIM disorders: 194470  
    UniProtKB/Swiss-Prot: ALBU_HUMAN, P02768
  • Familial dysalbuminemic hyperthyroxinemia (FDH) [MIM:103600]: Form of euthyroid hyperthyroxinemia that is
    due to increased affinity of ALB for T(4). It is the most common cause of inherited euthyroid hyperthyroxinemia
    in Caucasian population. Note=The disease is caused by mutations affecting the gene represented in this entry

  • 483 diseases for ALB (see first 20):    About MalaCards
    hepatorenal syndrome    dysalbuminemic hyperthyroxinemia    systemic capillary leak syndrome    bilateral choanal atresia
    blastomycosis    kallikrein hypertension    immunotactoid glomerulopathy    congenital analbuminemia
    dysalbuminemic hyperzincemia    peritonitis    protein-losing enteropathy    metabolic acidosis
    familial dysalbuminemic hyperthyroxinemia    hepatopulmonary syndrome    cronkhite-canada syndrome    hypertensive retinopathy
    tricuspid atresia    scurvy    peptic ulcer perforation    acute generalized exanthematous pustulosis
    apo a-i deficiency    chylous ascites    perinephritis    cap polyposis
    hyperthyroxinemia    kwashiorkor    kernicterus    hepatic tuberculosis
    familial hypertension    abdominal tuberculosis    hypoproteinemia, hypercatabolic    yellow nail syndrome
    lymphangitis    nephrotic syndrome, type 2    lipoid nephrosis    berger disease
    decubitus ulcer    marasmus    bronchiolitis obliterans organizing pneumonia    pulmonary arteriovenous malformation
    eosinophilic gastroenteritis    capillary leak syndrome    intestinal lymphangiectasia    anal fistula
    acute diarrhea    acute kidney failure    berylliosis    lipoprotein glomerulopathy
    congenital myotonic dystrophy    acute fatty liver of pregnancy    constrictive pericarditis    esophageal varix
    nephrotic syndrome    protein-energy malnutrition    pyelonephritis    gastroenteritis
    fournier gangrene    surfactant dysfunction    miliary tuberculosis    neonatal stroke
    ovarian hyperstimulation syndrome    pasteurellosis    warfarin resistance    choledocholithiasis
    renal hypertension    parametritis    pellagra    strongyloidiasis
    proteinuria    liver cirrhosis    hypersplenism    acrodermatitis enteropathica
    enteropathica    twin twin transfusion syndrome    twin-to-twin transfusion syndrome    compartment syndrome
    anuria    renal vascular disease    calciphylaxis    pericarditis
    focal glomerulosclerosis    viral pneumonia    pneumocystosis    glomerulonephritis
    nephrosis    chronic pyelonephritis    immune-complex glomerulonephritis    euthyroid sick syndrome
    t-lymphocytopenia    peptic ulcer    secondary amyloidosis    acute poststreptococcal glomerulonephritis
    lead poisoning    peripheral vascular disease    dysfibrinogenemia    choanal atresia
    pericardial effusion    bronchiolitis obliterans    lymphatic system disease    polyradiculoneuropathy
    hepatic encephalopathy    jaundice    arteriovenous malformation    salmonellosis
    intussusception    extrinsic allergic alveolitis    metabolic syndrome x    vascular disease
    chronic kidney failure    intracranial hypertension    nephritis    acrodermatitis
    gallbladder disease    dysphagia    bronchiolitis    liver disease
    gastric lymphoma    drug-induced hepatitis    common cold    interstitial nephritis
    intestinal pseudo-obstruction    steroid-resistant nephrotic syndrome    poems syndrome    diabetes, type 2
    renovascular hypertension    senile cataract    bacteriuria    intestinal obstruction
    familial hyperlipidemia    tuberculosis    autonomic neuropathy    becker muscular dystrophy
    acute pyelonephritis    obstructive lung disease    membranoproliferative glomerulonephritis    bone fracture
    portal vein thrombosis    fanconi syndrome    legionnaires' disease    hyperhomocysteinemia
    acute liver failure    proliferative glomerulonephritis    heparin-induced thrombocytopenia    meningoencephalitis
    maple syrup urine disease    uremia    cystinosis    placental choriocarcinoma
    hyperparathyroidism    lupus nephritis    pyoderma    castleman's disease
    focal segmental glomerulosclerosis    paracoccidioidomycosis    alport syndrome    membranous glomerulonephritis
    hydrops fetalis    type 1 diabetes    hypokalemia    diabetic ketoacidosis
    hyperphosphatemia    demyelinating polyneuropathy    cluster headache    iron deficiency anemia
    autoimmune pancreatitis    neonatal jaundice    porphyria cutanea tarda    dyskeratosis congenita
    short bowel syndrome    hiv/aids    pure red-cell aplasia    severe pre-eclampsia
    essential hypertension    thyrotoxicosis    stevens-johnson syndrome    tangier disease
    hepatitis b    diabetic retinopathy    diarrhea    paraneoplastic syndromes
    alagille syndrome    headache    tick-borne encephalitis    adult respiratory distress syndrome
    pre-eclampsia    blood clots    autonomic dysfunction    crohn's disease
    brain edema    nephrocalcinosis    homocystinuria    actinic keratosis
    prostate disease    eclampsia    hepatitis e    varicocele
    hypophosphatemia    rheumatic fever    head injury    type 1 diabetes mellitus
    alcoholic hepatitis    sleep disorder    food allergy    klebsiella
    hypercalcemia    alcoholic liver cirrhosis    congenital hypothyroidism    cholecystitis
    hypertension    clostridium difficile    bacterial meningitis    portal hypertension
    end stage renal failure    pulmonary embolism    macroglobulinemia    pneumonia
    dental caries    langerhans-cell histiocytosis    cystic kidney    west nile virus
    toxic shock syndrome    waldenstrom macroglobulinemia    cardiovascular disease risk factor )    phenylketonuria
    pulmonary edema    chronic graft versus host disease    appendicitis    obstructive jaundice
    myotonic dystrophy    hyperuricemia    porphyria    nonalcoholic steatohepatitis
    malt lymphoma    congenital disorder of glycosylation    thrombocytosis    gastroduodenitis
    visceral leishmaniasis    pemphigus vulgaris    wilson disease    diabetes mellitus
    hairy cell leukemia    leptospirosis    fibromyalgia    hepatitis a
    hemolytic-uremic syndrome    rickets    bronchiectasis    hemophilia
    histiocytosis    mastitis    primary hyperparathyroidism    primary sclerosing cholangitis
    diabetic neuropathy    sclerosing cholangitis    alcoholism    polyneuropathy
    eating disorder    pemphigus    biliary atresia    juvenile rheumatoid arthritis
    aspergillosis    cholangitis    keratosis    amyloidosis
    pulmonary sarcoidosis    familial hypercholesterolemia    thrombosis    gastric ulcer
    leukopenia    thrombocytopenia    viral hepatitis    hypothyroidism
    human immunodeficiency virus infectious disease    proliferative diabetic retinopathy    lactic acidosis    respiratory failure
    growth hormone deficiency    hepatitis    severe acute respiratory syndrome    bronchitis
    kidney disease    congestive heart failure    anemia    neuropathy
    glycogen storage disease    obesity, association with    sickle cell anemia    familial mediterranean fever
    primary biliary cirrhosis    beta thalassemia    open-angle glaucoma    thyroiditis
    glucose intolerance    acromegaly    primary open angle glaucoma    pandas
    hemolytic anemia    acquired immunodeficiency syndrome    diphtheria    dengue hemorrhagic fever
    hemochromatosis    interstitial lung disease    retinal disease    autoimmune hepatitis
    schistosomiasis    traumatic brain injury    aplastic anemia    goiter
    meningitis    otitis media    gigantism    thromboembolism
    esophagitis    leishmaniasis    t-cell leukemia    spinal cord injury
    cerebrovascular accident    kawasaki disease    venous thromboembolism    pulmonary tuberculosis
    thalassemia    small cell carcinoma    pharyngitis    hepatitis b virus infection
    myocarditis    hernia    graft versus host disease    brain injury
    tetanus    hypercholesterolemia    ischemic heart disease    hypertriglyceridemia
    sarcoidosis    hypersensitivity reaction type ii disease    morbid obesity    noma
    sleep apnea    protein s deficiency    eosinophilia    trypanosomiasis
    gestational diabetes    glaucoma    connective tissue disease    myasthenia gravis
    cerebral infarction    hyperglycemia    albinism    hemorrhagic fever
    hyperthyroidism    endocarditis    gastrointestinal stromal tumor    sickle cell disease
    hypertrophic cardiomyopathy    hypogonadism    uveitis    hematopoietic stem cell transplantation
    hypoglycemia    insulin resistance    cataract    metabolic disorders
    fatty liver disease    obesity    neutropenia    choriocarcinoma
    leprosy    idiopathic pulmonary fibrosis    polycystic kidney disease    peripheral neuropathy
    hiv type 1    skin cancer    hepatocellular carcinoma    cholestasis
    periodontal disease    adult t-cell leukemia    abdominal aortic aneurysm    allergic rhinitis
    pulmonary fibrosis    short stature    rabies    acute pancreatitis
    encephalitis    spondylitis    vasculitis    aortic aneurysm
    rhinitis    purpura    encephalomyelitis    alcohol dependence
    influenza    sjogren's syndrome    conjunctivitis    gastritis
    periodontitis    atherosclerosis    gout    brain disease
    measles    graves' disease    intellectual disability    skin disease
    sinusitis    celiac disease    anorexia nervosa    acute myocardial infarction
    duodenitis    blindness    muscular dystrophy    coronary heart disease
    chronic obstructive pulmonary disease    pancreatitis    pituitary adenoma    dilated cardiomyopathy
    cholera    oral cancer    basal cell carcinoma    myeloid leukemia
    myocardial infarction    malaria    hepatitis c    chronic myeloid leukemia
    atopic dermatitis    pertussis    malignant glioma    gingivitis
    thyroid cancer    choroiditis    intrahepatic cholangiocarcinoma    herpes simplex
    esophageal cancer    cytochrome p450    leukemia    lateral sclerosis
    myopathy    amyotrophic lateral sclerosis    dermatitis    cholangiocarcinoma
    asthma    down syndrome    multiple myeloma    dementia
    infertility    retinitis    rheumatoid arthritis    oral squamous cell carcinoma
    hodgkin's lymphoma    non-hodgkin lymphoma    cerebritis    b-cell lymphomas
    inflammatory bowel disease    cystic fibrosis    psoriasis    ischemia
    endotheliitis    arthritis    myeloma    acute lymphoblastic leukemia
    adenoma    lymphoblastic leukemia    acute myeloid leukemia    cervical cancer
    chronic lymphocytic leukemia    systemic lupus erythematosus    multiple sclerosis    lupus erythematosus
    renal cell carcinoma    cervicitis    squamous cell carcinoma    sarcoma
    prostatitis    pancreatic cancer    colon cancer    gastric cancer
    hypoxia    neuroblastoma    ovarian cancer    alzheimer's disease
    lung cancer    colorectal cancer    melanoma    adenocarcinoma
    prostate cancer    breast cancer    neuronitis

    20/69 diseases from the University of Copenhagen DISEASES database for ALB (see all 69):
    Diabetes mellitus     Proteinuria     Liver disease     Kidney failure
    Hypertension     Nephrotic syndrome     Lung disease     Nephritis
    Peritonitis     protein-energy malnutrition     protein-losing enteropathy     Hepatocellular carcinoma
    Heart disease     Anemia     Hepatitis B     Cerebrovascular accident
    Kernicterus     Hypersensitivity reaction type II disease     Peripheral vascular disease     Atherosclerosis

    ALB for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/96 Novoseek inferred disease relationships for ALB gene (see all 96)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    microalbuminuria 94.9 1034 7634745 (5), 9759691 (5), 15717883 (5), 12788992 (4) (see all 99)
    albuminuria 92.5 360 16703327 (5), 17405790 (5), 10489399 (4), 9179466 (4) (see all 99)
    hypoalbuminemia 90.4 275 1569418 (4), 19615208 (4), 9397418 (4), 10428270 (3) (see all 99)
    diabetic nephropathies 89.2 362 1881577 (4), 8264568 (3), 11131103 (3), 10198605 (3) (see all 99)
    renal disease 87 640 8163055 (4), 8593760 (4), 19729498 (3), 17928473 (3) (see all 99)
    proteinuria 86.2 625 12521234 (5), 9915226 (5), 16425574 (5), 1831839 (5) (see all 99)
    malnutrition 86 406 17957127 (4), 19218044 (4), 11592443 (3), 17321950 (3) (see all 99)
    renal failure chronic 80.6 103 2082760 (2), 1951474 (2), 9101098 (2), 1282889 (1) (see all 98)
    nephrotic syndrome 79.7 186 2082057 (6), 8502517 (5), 1379421 (3), 15481604 (3) (see all 99)
    protein-energy malnutrition 76.8 30 10219494 (2), 15695952 (2), 9106105 (1), 10433138 (1) (see all 24)

    Genetic Association Database (GAD): ALB
    Human Genome Epidemiology (HuGE) Navigator: ALB (17 documents)

    Export disorders for ALB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ALB gene, integrated from 9 sources (see all 8833):
    (articles sorted by number of sources associating them with ALB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Crystal structures of human serum albumin complexed with monounsaturated and polyunsaturated fatty acids. (PubMed id 11743713)1, 2, 7 Petitpas I.... Curry S. (2001)
    2. Identification of a human serum albumin species associated with familial dysalbuminemic hyperthyroxinemia. (PubMed id 7852505)1, 2, 9 Rushbrook J.I.... Divino C.M. (1995)
    3. A nucleotide insertion and frameshift cause albumin Kenitra, an extended and O-glycosylated mutant of human serum albumin with two additional disulfide bridges. (PubMed id 11168369)1, 2, 9 Minchiotti L....Galliano M. (2001)
    4. Crystal structure of human serum albumin at 2.5-A resolution. (PubMed id 10388840)1, 2, 9 Sugio S.... Kobayashi K. (1999)
    5. Protein and DNA sequence analysis of a 'private' genetic variant: albumin Ortonovo (Glu-505-->Lys). (PubMed id 7902134)1, 2, 9 Galliano M.... Putnam F.W. (1993)
    6. Two alloalbumins with identical electrophoretic mobility are produced by differently charged amino acid substitutions. (PubMed id 1347703)1, 2, 9 Minchiotti L.... Porta F. (1992)
    7. Genetic variants of serum albumin in Americans and Japanese. (PubMed id 1946412)1, 2, 9 Madison J.... Putnam F.W. (1991)
    8. Allostery in a monomeric protein: the case of human s erum albumin. (PubMed id 20346571)1, 7 Ascenzi P. and Fasano M. (2010)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 213 HGNC: 399 AceView: ALB Ensembl:ENSG00000163631 euGenes: HUgn213
    ECgene: ALB H-InvDB: ALB

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ALB Pharmacogenomics, SNPs, Pathways
    Albumin Websitehttp://www.albumin.org
    Wikipedia http://en.wikipedia.org/wiki/Serum_albumin
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/ALB
    SeattleSNPshttp://pga.gs.washington.edu/data/alb/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ALB gene:
    Search GeneIP for patents involving ALB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
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     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for ALB   OriGene RNAi products in human, mouse, rat for ALB  
     OriGene qPCR primer pairs and template standards for ALB   OriGene Protein Over-expression Lysate for ALB  
     OriGene MassSpec something-or-other for ALB   OriGene clones in human, mouse for ALB  
     OriGene qSTAR qPCR primer pairs in human, mouse for ALB   OriGene Purified Protein for ALB  
     OriGene ORF clones in mouse, rat for ALB   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ALB   OriGene Custom Protein Services for ALB  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ALB
     QIAGEN SeqTarget long-range PCR primers for resequencing ALB
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ALB
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ALB
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ALB
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ALB
     GenScript Custom Purified and Recombinant Proteins Services for ALB GenScript cDNA clones with any tag delivered in your preferred vector for ALB
     GenScript Custom Assay Services for ALB GenScript Superior Antibodies for ALB
     GenScript Custom overexpressing Cell Line Services for ALB CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for ALB  (albumin)

     Regulatory tfbs in ALB promoter
     Search Chromatin IP Primers for ALB
     RT2 qPCR Primer Assay in human, mouse, rat ALB
     GNC Network for ALB
     SABiosciences PCR Arrays including human, mouse, rat ALB
     Search Tocris compounds for ALB (ALBU)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for ALB
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
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     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
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     See all of Abcam's Antibodies, Kits and Proteins for ALB
     Custom Antibody / Protein Production Service
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     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for ALB




     Proteins for ALB
     Antibodies for ALB
     ELISAs for ALB
     CLIAs for ALB
     Search LifeMap BioReagents cell lines for ALB
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ALB
     SwitchGear 3'UTR luciferase reporter plasmids for ALB
     SwitchGear Promoter luciferase reporter plasmids for ALB
     ThermoFisher Antibody for ALB
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ALB
     inGenious Targeting Laboratory - Custom generated mouse model solutions for ALB
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ALB
    Customized:
     lentivirus for stable overexpression of ALB
     lentivirus expression plasmids for stable overexpression of ALB
     adenovirus for overexpression of ALB
     LSBio Antibodies in human, mouse, rat for ALB
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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